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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:FGD3-SYK (FusionGDB2 ID:HG89846TG6850) |
Fusion Gene Summary for FGD3-SYK |
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Fusion gene information | Fusion gene name: FGD3-SYK | Fusion gene ID: hg89846tg6850 | Hgene | Tgene | Gene symbol | FGD3 | SYK | Gene ID | 89846 | 6850 |
Gene name | FYVE, RhoGEF and PH domain containing 3 | spleen associated tyrosine kinase | |
Synonyms | ZFYVE5 | p72-Syk | |
Cytomap | ('FGD3')('SYK') 9q22.31 | 9q22.2 | |
Type of gene | protein-coding | protein-coding | |
Description | FYVE, RhoGEF and PH domain-containing protein 3FGD1 family, member 3faciogenital dysplasia 3zinc finger FYVE domain-containing protein 5 | tyrosine-protein kinase SYKspleen tyrosine kinase | |
Modification date | 20200313 | 20200329 | |
UniProtAcc | . | P43405 | |
Ensembl transtripts involved in fusion gene | ENST00000375482, ENST00000337352, ENST00000416701, ENST00000468206, ENST00000538555, | ||
Fusion gene scores | * DoF score | 3 X 3 X 3=27 | 9 X 9 X 6=486 |
# samples | 3 | 9 | |
** MAII score | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | log2(9/486*10)=-2.43295940727611 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: FGD3 [Title/Abstract] AND SYK [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | FGD3(95710011)-SYK(93606140), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | SYK | GO:0006468 | protein phosphorylation | 17681949 |
Tgene | SYK | GO:0007159 | leukocyte cell-cell adhesion | 12885943 |
Tgene | SYK | GO:0030593 | neutrophil chemotaxis | 12885943 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | BLCA | TCGA-DK-A2I1-01A | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
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Fusion Gene ORF analysis for FGD3-SYK |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5UTR-3UTR | ENST00000375482 | ENST00000476708 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
5UTR-5UTR | ENST00000375482 | ENST00000375746 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
5UTR-5UTR | ENST00000375482 | ENST00000375747 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
5UTR-5UTR | ENST00000375482 | ENST00000375751 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
5UTR-5UTR | ENST00000375482 | ENST00000375754 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
intron-3UTR | ENST00000337352 | ENST00000476708 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
intron-3UTR | ENST00000416701 | ENST00000476708 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
intron-3UTR | ENST00000468206 | ENST00000476708 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
intron-3UTR | ENST00000538555 | ENST00000476708 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
intron-5UTR | ENST00000337352 | ENST00000375746 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
intron-5UTR | ENST00000337352 | ENST00000375747 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
intron-5UTR | ENST00000337352 | ENST00000375751 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
intron-5UTR | ENST00000337352 | ENST00000375754 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
intron-5UTR | ENST00000416701 | ENST00000375746 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
intron-5UTR | ENST00000416701 | ENST00000375747 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
intron-5UTR | ENST00000416701 | ENST00000375751 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
intron-5UTR | ENST00000416701 | ENST00000375754 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
intron-5UTR | ENST00000468206 | ENST00000375746 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
intron-5UTR | ENST00000468206 | ENST00000375747 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
intron-5UTR | ENST00000468206 | ENST00000375751 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
intron-5UTR | ENST00000468206 | ENST00000375754 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
intron-5UTR | ENST00000538555 | ENST00000375746 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
intron-5UTR | ENST00000538555 | ENST00000375747 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
intron-5UTR | ENST00000538555 | ENST00000375751 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
intron-5UTR | ENST00000538555 | ENST00000375754 | FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606140 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for FGD3-SYK |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606139 | + | 1.83E-07 | 0.99999976 |
FGD3 | chr9 | 95710011 | + | SYK | chr9 | 93606139 | + | 1.83E-07 | 0.99999976 |
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Fusion Protein Features for FGD3-SYK |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:95710011/:93606140) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | SYK |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Non-receptor tyrosine kinase which mediates signal transduction downstream of a variety of transmembrane receptors including classical immunoreceptors like the B-cell receptor (BCR). Regulates several biological processes including innate and adaptive immunity, cell adhesion, osteoclast maturation, platelet activation and vascular development. Assembles into signaling complexes with activated receptors at the plasma membrane via interaction between its SH2 domains and the receptor tyrosine-phosphorylated ITAM domains. The association with the receptor can also be indirect and mediated by adapter proteins containing ITAM or partial hemITAM domains. The phosphorylation of the ITAM domains is generally mediated by SRC subfamily kinases upon engagement of the receptor. More rarely signal transduction via SYK could be ITAM-independent. Direct downstream effectors phosphorylated by SYK include VAV1, PLCG1, PI-3-kinase, LCP2 and BLNK. Initially identified as essential in B-cell receptor (BCR) signaling, it is necessary for the maturation of B-cells most probably at the pro-B to pre-B transition. Activated upon BCR engagement, it phosphorylates and activates BLNK an adapter linking the activated BCR to downstream signaling adapters and effectors. It also phosphorylates and activates PLCG1 and the PKC signaling pathway. It also phosphorylates BTK and regulates its activity in B-cell antigen receptor (BCR)-coupled signaling. In addition to its function downstream of BCR plays also a role in T-cell receptor signaling. Plays also a crucial role in the innate immune response to fungal, bacterial and viral pathogens. It is for instance activated by the membrane lectin CLEC7A. Upon stimulation by fungal proteins, CLEC7A together with SYK activates immune cells inducing the production of ROS. Also activates the inflammasome and NF-kappa-B-mediated transcription of chemokines and cytokines in presence of pathogens. Regulates neutrophil degranulation and phagocytosis through activation of the MAPK signaling cascade (By similarity). Required for the stimulation of neutrophil phagocytosis by IL15 (PubMed:15123770). Also mediates the activation of dendritic cells by cell necrosis stimuli. Also involved in mast cells activation. Involved in interleukin-3/IL3-mediated signaling pathway in basophils (By similarity). Also functions downstream of receptors mediating cell adhesion. Relays for instance, integrin-mediated neutrophils and macrophages activation and P-selectin receptor/SELPG-mediated recruitment of leukocytes to inflammatory loci. Plays also a role in non-immune processes. It is for instance involved in vascular development where it may regulate blood and lymphatic vascular separation. It is also required for osteoclast development and function. Functions in the activation of platelets by collagen, mediating PLCG2 phosphorylation and activation. May be coupled to the collagen receptor by the ITAM domain-containing FCER1G. Also activated by the membrane lectin CLEC1B that is required for activation of platelets by PDPN/podoplanin. Involved in platelet adhesion being activated by ITGB3 engaged by fibrinogen. Together with CEACAM20, enhances production of the cytokine CXCL8/IL-8 via the NFKB pathway and may thus have a role in the intestinal immune response (By similarity). {ECO:0000250|UniProtKB:P48025, ECO:0000269|PubMed:12387735, ECO:0000269|PubMed:12456653, ECO:0000269|PubMed:15123770, ECO:0000269|PubMed:15388330, ECO:0000269|PubMed:19909739, ECO:0000269|PubMed:8657103, ECO:0000269|PubMed:9535867}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for FGD3-SYK |
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Fusion Gene PPI Analysis for FGD3-SYK |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for FGD3-SYK |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
Tgene | SYK | P43405 | DB12010 | Fostamatinib | Inhibitor | Small molecule | Approved|Investigational |
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Related Diseases for FGD3-SYK |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Tgene | C0025202 | melanoma | 1 | CTD_human | |
Tgene | C0025500 | Mesothelioma | 1 | CTD_human |