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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ATG16L2-TP53BP2 (FusionGDB2 ID:HG89849TG7159)

Fusion Gene Summary for ATG16L2-TP53BP2

check button Fusion gene summary
Fusion gene informationFusion gene name: ATG16L2-TP53BP2
Fusion gene ID: hg89849tg7159
HgeneTgene
Gene symbol

ATG16L2

TP53BP2

Gene ID

89849

7159

Gene nameautophagy related 16 like 2tumor protein p53 binding protein 2
SynonymsATG16B|WDR8053BP2|ASPP2|BBP|P53BP2|PPP1R13A
Cytomap('ATG16L2')('TP53BP2')

11q13.4

1q41

Type of geneprotein-codingprotein-coding
Descriptionautophagy-related protein 16-2APG16-like 2ATG16 autophagy related 16-like 2WD repeat-containing protein 80apoptosis-stimulating of p53 protein 2BCL2-binding proteinapoptosis-stimulating protein of p53, 2renal carcinoma antigen NY-REN-51tumor suppressor p53-binding protein 2
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000321297, ENST00000534905, 
ENST00000451353, 
Fusion gene scores* DoF score2 X 2 X 2=83 X 3 X 3=27
# samples 23
** MAII scorelog2(2/8*10)=1.32192809488736log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: ATG16L2 [Title/Abstract] AND TP53BP2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointATG16L2(72528900)-TP53BP2(223980224), # samples:1
Anticipated loss of major functional domain due to fusion event.ATG16L2-TP53BP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATG16L2-TP53BP2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ATG16L2-TP53BP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ATG16L2-TP53BP2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTP53BP2

GO:0072332

intrinsic apoptotic signaling pathway by p53 class mediator

11684014


check buttonFusion gene breakpoints across ATG16L2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TP53BP2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-24-1434ATG16L2chr11

72528900

+TP53BP2chr1

223980224

-


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Fusion Gene ORF analysis for ATG16L2-TP53BP2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000321297ENST00000498843ATG16L2chr11

72528900

+TP53BP2chr1

223980224

-
5CDS-5UTRENST00000534905ENST00000498843ATG16L2chr11

72528900

+TP53BP2chr1

223980224

-
In-frameENST00000321297ENST00000343537ATG16L2chr11

72528900

+TP53BP2chr1

223980224

-
In-frameENST00000321297ENST00000391878ATG16L2chr11

72528900

+TP53BP2chr1

223980224

-
In-frameENST00000321297ENST00000391879ATG16L2chr11

72528900

+TP53BP2chr1

223980224

-
In-frameENST00000534905ENST00000343537ATG16L2chr11

72528900

+TP53BP2chr1

223980224

-
In-frameENST00000534905ENST00000391878ATG16L2chr11

72528900

+TP53BP2chr1

223980224

-
In-frameENST00000534905ENST00000391879ATG16L2chr11

72528900

+TP53BP2chr1

223980224

-
intron-3CDSENST00000451353ENST00000343537ATG16L2chr11

72528900

+TP53BP2chr1

223980224

-
intron-3CDSENST00000451353ENST00000391878ATG16L2chr11

72528900

+TP53BP2chr1

223980224

-
intron-3CDSENST00000451353ENST00000391879ATG16L2chr11

72528900

+TP53BP2chr1

223980224

-
intron-5UTRENST00000451353ENST00000498843ATG16L2chr11

72528900

+TP53BP2chr1

223980224

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000321297ATG16L2chr1172528900+ENST00000391878TP53BP2chr1223980224-1953456138998286
ENST00000321297ATG16L2chr1172528900+ENST00000343537TP53BP2chr1223980224-1953456138998286
ENST00000321297ATG16L2chr1172528900+ENST00000391879TP53BP2chr1223980224-1207456138998286
ENST00000534905ATG16L2chr1172528900+ENST00000391878TP53BP2chr1223980224-185535840900286
ENST00000534905ATG16L2chr1172528900+ENST00000343537TP53BP2chr1223980224-185535840900286
ENST00000534905ATG16L2chr1172528900+ENST00000391879TP53BP2chr1223980224-110935840900286

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000321297ENST00000391878ATG16L2chr1172528900+TP53BP2chr1223980224-0.0005225170.99947757
ENST00000321297ENST00000343537ATG16L2chr1172528900+TP53BP2chr1223980224-0.0005225170.99947757
ENST00000321297ENST00000391879ATG16L2chr1172528900+TP53BP2chr1223980224-0.0017898750.9982102
ENST00000534905ENST00000391878ATG16L2chr1172528900+TP53BP2chr1223980224-0.0004526030.9995474
ENST00000534905ENST00000343537ATG16L2chr1172528900+TP53BP2chr1223980224-0.0004526030.9995474
ENST00000534905ENST00000391879ATG16L2chr1172528900+TP53BP2chr1223980224-0.0011807970.9988192

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Fusion Genomic Features for ATG16L2-TP53BP2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ATG16L2-TP53BP2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:72528900/chr1:223980224)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTP53BP2chr11:72528900chr1:223980224ENST000003918781419824_9028251006.0Compositional biasNote=Pro-rich
TgeneTP53BP2chr11:72528900chr1:223980224ENST0000034353713181057_11199541135.0DomainSH3
TgeneTP53BP2chr11:72528900chr1:223980224ENST0000039187814191057_11198251006.0DomainSH3
TgeneTP53BP2chr11:72528900chr1:223980224ENST000003918781419866_8758251006.0MotifSH3-binding
TgeneTP53BP2chr11:72528900chr1:223980224ENST0000034353713181025_10679541135.0RepeatNote=ANK 4
TgeneTP53BP2chr11:72528900chr1:223980224ENST000003435371318958_9909541135.0RepeatNote=ANK 2
TgeneTP53BP2chr11:72528900chr1:223980224ENST000003435371318991_10249541135.0RepeatNote=ANK 3
TgeneTP53BP2chr11:72528900chr1:223980224ENST0000039187814191025_10678251006.0RepeatNote=ANK 4
TgeneTP53BP2chr11:72528900chr1:223980224ENST000003918781419926_9578251006.0RepeatNote=ANK 1
TgeneTP53BP2chr11:72528900chr1:223980224ENST000003918781419958_9908251006.0RepeatNote=ANK 2
TgeneTP53BP2chr11:72528900chr1:223980224ENST000003918781419991_10248251006.0RepeatNote=ANK 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneATG16L2chr11:72528900chr1:223980224ENST00000321297+318116_227106620.0Coiled coilOntology_term=ECO:0000255
HgeneATG16L2chr11:72528900chr1:223980224ENST00000321297+318334_373106620.0RepeatWD 1
HgeneATG16L2chr11:72528900chr1:223980224ENST00000321297+318378_417106620.0RepeatWD 2
HgeneATG16L2chr11:72528900chr1:223980224ENST00000321297+318420_454106620.0RepeatWD 3
HgeneATG16L2chr11:72528900chr1:223980224ENST00000321297+318455_498106620.0RepeatWD 4
HgeneATG16L2chr11:72528900chr1:223980224ENST00000321297+318500_539106620.0RepeatWD 5
HgeneATG16L2chr11:72528900chr1:223980224ENST00000321297+318546_585106620.0RepeatWD 6
HgeneATG16L2chr11:72528900chr1:223980224ENST00000321297+318589_619106620.0RepeatWD 7
TgeneTP53BP2chr11:72528900chr1:223980224ENST000003435371318132_1739541135.0Compositional biasNote=Gln-rich
TgeneTP53BP2chr11:72528900chr1:223980224ENST000003435371318824_9029541135.0Compositional biasNote=Pro-rich
TgeneTP53BP2chr11:72528900chr1:223980224ENST000003918781419132_1738251006.0Compositional biasNote=Gln-rich
TgeneTP53BP2chr11:72528900chr1:223980224ENST000003435371318866_8759541135.0MotifSH3-binding
TgeneTP53BP2chr11:72528900chr1:223980224ENST000003435371318926_9579541135.0RepeatNote=ANK 1


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Fusion Gene Sequence for ATG16L2-TP53BP2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7539_7539_1_ATG16L2-TP53BP2_ATG16L2_chr11_72528900_ENST00000321297_TP53BP2_chr1_223980224_ENST00000343537_length(transcript)=1953nt_BP=456nt
CCAAAGCCCTCTTGGGACAAGCCGGGGATTCCCCGCCGCCGCCCGCCCCCTGGCGTCACGGAGTCCCCGCGAGGCCCCGCCCCGGCCTGG
CGCCGTCCTGGGCGGGAGGAACGCGCCGCTAGGCGGGAGAGCGCGGCCATGGCGGGGCCGGGCGTCCCCGGTGCCCCCGCAGCGCGCTGG
AAACGCCACATCGTGCGGCAGCTGCGGCTTCGGGACCGTACGCAAAAGGCGCTTTTCCTGGAGCTGGTGCCGGCCTATAACCATCTCTTA
GAGAAGGCTGAGCTGCTGGACAAGTTCTCAAAGAAGCTGCAGCCGGAGCCAAACAGTGTCACTCCCACCACCCACCAGGGCCCCTGGGAG
GAGTCAGAGCTTGACTCAGACCAAGTCCCATCACTGGTCGCACTGAGGGTGAAGTGGCAGGAGGAGGAGGAGGGGCTCCGGCTGGTCTGT
GGTGAGGTTGATGACCCAAGCCTCCCCAATGATGAAGGCATCACGGCTCTTCACAATGCTGTGTGTGCAGGCCACACAGAAATCGTTAAG
TTCCTGGTACAGTTTGGTGTAAATGTAAATGCTGCTGATAGTGATGGATGGACTCCATTACATTGTGCTGCCTCATGTAACAACGTCCAA
GTGTGTAAGTTTTTGGTGGAGTCAGGAGCCGCTGTGTTTGCCATGACCTACAGTGACATGCAGACTGCTGCAGATAAGTGCGAGGAAATG
GAGGAAGGCTACACTCAGTGCTCCCAATTTCTTTATGGAGTTCAGGAGAAGATGGGCATAATGAATAAAGGAGTCATTTATGCGCTTTGG
GATTATGAACCTCAGAATGATGATGAGCTGCCCATGAAAGAAGGAGACTGCATGACAATCATCCACAGGGAAGACGAAGATGAAATCGAA
TGGTGGTGGGCGCGCCTTAATGATAAGGAGGGATATGTTCCACGTAACTTGCTGGGACTGTACCCAAGAATTAAACCAAGACAAAGGAGC
TTGGCCTGAAACTTCCACACAGAATTTTAGTCAATGAAGAATTAATCTCTGTTAAGAAGAAGTAATACGATTATTTTTGGCAAAAATTTC
ACAAGACTTATTTTAATGACAATGTAGCTTGAAAGCGATGAAGAATGTCTCTAGAAGAGAATGAAGGATTGAAGAATTCACCATTAGAGG
ACATTTAGCGTGATGAAATAAAGCATCTACGTCAGCAGGCCATACTGTGTTGGGGCAAAGGTGTCCCGTGTAGCACTCAGATAAGTATAC
AGCGACAATCCTGTTTTCTACAAGAATCCTGTCTAGTAAATAGGATCATTTATTGGGCAGTTGGGAAATCAGCTCTCTGTCCTGTTGAGT
GTTTTCAGCAGCTGCTCCTAAACCAGTCCTCCTGCCAGAAAGGACCAGTGCCGTCACATCGCTGTCTCTGATTGTCCCCGGCACCAGCAG
GCCCTTGGGGGGCTCACCTGAAGGCTCGAAGGCACTGCACACTTGTATATTGTCAGTGAAGAACTGTTAGTTGGTTGTCAGTGAACAATA
ACTTTATTATATGAGTTTTTGTAGCATCTTAAGAATTATACATATGTTTGAAATATTGAAACTAAGCTACGGTACCAGTAATTAGATGTA
GAATCTTGTTTGTAGGCTGAATTTTAATCTGTATTTATTGTCTTTTGTATCTCAGAAATTAGAAACTTGCTACAGACTTACCCGTAATAT
TTGTCAAGATCATAGCTGACTTTAAAAACAGTTGTAATAAACTTTTTGATGCTAGCTGTTTACTGGTTTTTGTTTTTGATGTCATAAATA
GACCTTGTTTAATAGTCACAAGCCGTTGGGATATCATACCCAGCTGAAAAAGAACAAACTGCTTAACATAAGTATATGTATCGTAATAAG
AGTTTTTTACCAGCTAAGTGATTCAATGTAAGTGGTTTTTAAAATAAAATACTGTAGAGATCA

>7539_7539_1_ATG16L2-TP53BP2_ATG16L2_chr11_72528900_ENST00000321297_TP53BP2_chr1_223980224_ENST00000343537_length(amino acids)=286AA_BP=106
MAGPGVPGAPAARWKRHIVRQLRLRDRTQKALFLELVPAYNHLLEKAELLDKFSKKLQPEPNSVTPTTHQGPWEESELDSDQVPSLVALR
VKWQEEEEGLRLVCGEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMT
YSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGVIYALWDYEPQNDDELPMKEGDCMTIIHREDEDEIEWWWARLNDKEGYVPRN
LLGLYPRIKPRQRSLA

--------------------------------------------------------------
>7539_7539_2_ATG16L2-TP53BP2_ATG16L2_chr11_72528900_ENST00000321297_TP53BP2_chr1_223980224_ENST00000391878_length(transcript)=1953nt_BP=456nt
CCAAAGCCCTCTTGGGACAAGCCGGGGATTCCCCGCCGCCGCCCGCCCCCTGGCGTCACGGAGTCCCCGCGAGGCCCCGCCCCGGCCTGG
CGCCGTCCTGGGCGGGAGGAACGCGCCGCTAGGCGGGAGAGCGCGGCCATGGCGGGGCCGGGCGTCCCCGGTGCCCCCGCAGCGCGCTGG
AAACGCCACATCGTGCGGCAGCTGCGGCTTCGGGACCGTACGCAAAAGGCGCTTTTCCTGGAGCTGGTGCCGGCCTATAACCATCTCTTA
GAGAAGGCTGAGCTGCTGGACAAGTTCTCAAAGAAGCTGCAGCCGGAGCCAAACAGTGTCACTCCCACCACCCACCAGGGCCCCTGGGAG
GAGTCAGAGCTTGACTCAGACCAAGTCCCATCACTGGTCGCACTGAGGGTGAAGTGGCAGGAGGAGGAGGAGGGGCTCCGGCTGGTCTGT
GGTGAGGTTGATGACCCAAGCCTCCCCAATGATGAAGGCATCACGGCTCTTCACAATGCTGTGTGTGCAGGCCACACAGAAATCGTTAAG
TTCCTGGTACAGTTTGGTGTAAATGTAAATGCTGCTGATAGTGATGGATGGACTCCATTACATTGTGCTGCCTCATGTAACAACGTCCAA
GTGTGTAAGTTTTTGGTGGAGTCAGGAGCCGCTGTGTTTGCCATGACCTACAGTGACATGCAGACTGCTGCAGATAAGTGCGAGGAAATG
GAGGAAGGCTACACTCAGTGCTCCCAATTTCTTTATGGAGTTCAGGAGAAGATGGGCATAATGAATAAAGGAGTCATTTATGCGCTTTGG
GATTATGAACCTCAGAATGATGATGAGCTGCCCATGAAAGAAGGAGACTGCATGACAATCATCCACAGGGAAGACGAAGATGAAATCGAA
TGGTGGTGGGCGCGCCTTAATGATAAGGAGGGATATGTTCCACGTAACTTGCTGGGACTGTACCCAAGAATTAAACCAAGACAAAGGAGC
TTGGCCTGAAACTTCCACACAGAATTTTAGTCAATGAAGAATTAATCTCTGTTAAGAAGAAGTAATACGATTATTTTTGGCAAAAATTTC
ACAAGACTTATTTTAATGACAATGTAGCTTGAAAGCGATGAAGAATGTCTCTAGAAGAGAATGAAGGATTGAAGAATTCACCATTAGAGG
ACATTTAGCGTGATGAAATAAAGCATCTACGTCAGCAGGCCATACTGTGTTGGGGCAAAGGTGTCCCGTGTAGCACTCAGATAAGTATAC
AGCGACAATCCTGTTTTCTACAAGAATCCTGTCTAGTAAATAGGATCATTTATTGGGCAGTTGGGAAATCAGCTCTCTGTCCTGTTGAGT
GTTTTCAGCAGCTGCTCCTAAACCAGTCCTCCTGCCAGAAAGGACCAGTGCCGTCACATCGCTGTCTCTGATTGTCCCCGGCACCAGCAG
GCCCTTGGGGGGCTCACCTGAAGGCTCGAAGGCACTGCACACTTGTATATTGTCAGTGAAGAACTGTTAGTTGGTTGTCAGTGAACAATA
ACTTTATTATATGAGTTTTTGTAGCATCTTAAGAATTATACATATGTTTGAAATATTGAAACTAAGCTACGGTACCAGTAATTAGATGTA
GAATCTTGTTTGTAGGCTGAATTTTAATCTGTATTTATTGTCTTTTGTATCTCAGAAATTAGAAACTTGCTACAGACTTACCCGTAATAT
TTGTCAAGATCATAGCTGACTTTAAAAACAGTTGTAATAAACTTTTTGATGCTAGCTGTTTACTGGTTTTTGTTTTTGATGTCATAAATA
GACCTTGTTTAATAGTCACAAGCCGTTGGGATATCATACCCAGCTGAAAAAGAACAAACTGCTTAACATAAGTATATGTATCGTAATAAG
AGTTTTTTACCAGCTAAGTGATTCAATGTAAGTGGTTTTTAAAATAAAATACTGTAGAGATCA

>7539_7539_2_ATG16L2-TP53BP2_ATG16L2_chr11_72528900_ENST00000321297_TP53BP2_chr1_223980224_ENST00000391878_length(amino acids)=286AA_BP=106
MAGPGVPGAPAARWKRHIVRQLRLRDRTQKALFLELVPAYNHLLEKAELLDKFSKKLQPEPNSVTPTTHQGPWEESELDSDQVPSLVALR
VKWQEEEEGLRLVCGEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMT
YSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGVIYALWDYEPQNDDELPMKEGDCMTIIHREDEDEIEWWWARLNDKEGYVPRN
LLGLYPRIKPRQRSLA

--------------------------------------------------------------
>7539_7539_3_ATG16L2-TP53BP2_ATG16L2_chr11_72528900_ENST00000321297_TP53BP2_chr1_223980224_ENST00000391879_length(transcript)=1207nt_BP=456nt
CCAAAGCCCTCTTGGGACAAGCCGGGGATTCCCCGCCGCCGCCCGCCCCCTGGCGTCACGGAGTCCCCGCGAGGCCCCGCCCCGGCCTGG
CGCCGTCCTGGGCGGGAGGAACGCGCCGCTAGGCGGGAGAGCGCGGCCATGGCGGGGCCGGGCGTCCCCGGTGCCCCCGCAGCGCGCTGG
AAACGCCACATCGTGCGGCAGCTGCGGCTTCGGGACCGTACGCAAAAGGCGCTTTTCCTGGAGCTGGTGCCGGCCTATAACCATCTCTTA
GAGAAGGCTGAGCTGCTGGACAAGTTCTCAAAGAAGCTGCAGCCGGAGCCAAACAGTGTCACTCCCACCACCCACCAGGGCCCCTGGGAG
GAGTCAGAGCTTGACTCAGACCAAGTCCCATCACTGGTCGCACTGAGGGTGAAGTGGCAGGAGGAGGAGGAGGGGCTCCGGCTGGTCTGT
GGTGAGGTTGATGACCCAAGCCTCCCCAATGATGAAGGCATCACGGCTCTTCACAATGCTGTGTGTGCAGGCCACACAGAAATCGTTAAG
TTCCTGGTACAGTTTGGTGTAAATGTAAATGCTGCTGATAGTGATGGATGGACTCCATTACATTGTGCTGCCTCATGTAACAACGTCCAA
GTGTGTAAGTTTTTGGTGGAGTCAGGAGCCGCTGTGTTTGCCATGACCTACAGTGACATGCAGACTGCTGCAGATAAGTGCGAGGAAATG
GAGGAAGGCTACACTCAGTGCTCCCAATTTCTTTATGGAGTTCAGGAGAAGATGGGCATAATGAATAAAGGAGTCATTTATGCGCTTTGG
GATTATGAACCTCAGAATGATGATGAGCTGCCCATGAAAGAAGGAGACTGCATGACAATCATCCACAGGGAAGACGAAGATGAAATCGAA
TGGTGGTGGGCGCGCCTTAATGATAAGGAGGGATATGTTCCACGTAACTTGCTGGGACTGTACCCAAGAATTAAACCAAGACAAAGGAGC
TTGGCCTGAAACTTCCACACAGAATTTTAGTCAATGAAGAATTAATCTCTGTTAAGAAGAAGTAATACGATTATTTTTGGCAAAAATTTC
ACAAGACTTATTTTAATGACAATGTAGCTTGAAAGCGATGAAGAATGTCTCTAGAAGAGAATGAAGGATTGAAGAATTCACCATTAGAGG
ACATTTAGCGTGATGAAATAAAGCATCTACGTCAGCA

>7539_7539_3_ATG16L2-TP53BP2_ATG16L2_chr11_72528900_ENST00000321297_TP53BP2_chr1_223980224_ENST00000391879_length(amino acids)=286AA_BP=106
MAGPGVPGAPAARWKRHIVRQLRLRDRTQKALFLELVPAYNHLLEKAELLDKFSKKLQPEPNSVTPTTHQGPWEESELDSDQVPSLVALR
VKWQEEEEGLRLVCGEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMT
YSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGVIYALWDYEPQNDDELPMKEGDCMTIIHREDEDEIEWWWARLNDKEGYVPRN
LLGLYPRIKPRQRSLA

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>7539_7539_4_ATG16L2-TP53BP2_ATG16L2_chr11_72528900_ENST00000534905_TP53BP2_chr1_223980224_ENST00000343537_length(transcript)=1855nt_BP=358nt
TGGGCGGGAGGAACGCGCCGCTAGGCGGGAGAGCGCGGCCATGGCGGGGCCGGGCGTCCCCGGTGCCCCCGCAGCGCGCTGGAAACGCCA
CATCGTGCGGCAGCTGCGGCTTCGGGACCGTACGCAAAAGGCGCTTTTCCTGGAGCTGGTGCCGGCCTATAACCATCTCTTAGAGAAGGC
TGAGCTGCTGGACAAGTTCTCAAAGAAGCTGCAGCCGGAGCCAAACAGTGTCACTCCCACCACCCACCAGGGCCCCTGGGAGGAGTCAGA
GCTTGACTCAGACCAAGTCCCATCACTGGTCGCACTGAGGGTGAAGTGGCAGGAGGAGGAGGAGGGGCTCCGGCTGGTCTGTGGTGAGGT
TGATGACCCAAGCCTCCCCAATGATGAAGGCATCACGGCTCTTCACAATGCTGTGTGTGCAGGCCACACAGAAATCGTTAAGTTCCTGGT
ACAGTTTGGTGTAAATGTAAATGCTGCTGATAGTGATGGATGGACTCCATTACATTGTGCTGCCTCATGTAACAACGTCCAAGTGTGTAA
GTTTTTGGTGGAGTCAGGAGCCGCTGTGTTTGCCATGACCTACAGTGACATGCAGACTGCTGCAGATAAGTGCGAGGAAATGGAGGAAGG
CTACACTCAGTGCTCCCAATTTCTTTATGGAGTTCAGGAGAAGATGGGCATAATGAATAAAGGAGTCATTTATGCGCTTTGGGATTATGA
ACCTCAGAATGATGATGAGCTGCCCATGAAAGAAGGAGACTGCATGACAATCATCCACAGGGAAGACGAAGATGAAATCGAATGGTGGTG
GGCGCGCCTTAATGATAAGGAGGGATATGTTCCACGTAACTTGCTGGGACTGTACCCAAGAATTAAACCAAGACAAAGGAGCTTGGCCTG
AAACTTCCACACAGAATTTTAGTCAATGAAGAATTAATCTCTGTTAAGAAGAAGTAATACGATTATTTTTGGCAAAAATTTCACAAGACT
TATTTTAATGACAATGTAGCTTGAAAGCGATGAAGAATGTCTCTAGAAGAGAATGAAGGATTGAAGAATTCACCATTAGAGGACATTTAG
CGTGATGAAATAAAGCATCTACGTCAGCAGGCCATACTGTGTTGGGGCAAAGGTGTCCCGTGTAGCACTCAGATAAGTATACAGCGACAA
TCCTGTTTTCTACAAGAATCCTGTCTAGTAAATAGGATCATTTATTGGGCAGTTGGGAAATCAGCTCTCTGTCCTGTTGAGTGTTTTCAG
CAGCTGCTCCTAAACCAGTCCTCCTGCCAGAAAGGACCAGTGCCGTCACATCGCTGTCTCTGATTGTCCCCGGCACCAGCAGGCCCTTGG
GGGGCTCACCTGAAGGCTCGAAGGCACTGCACACTTGTATATTGTCAGTGAAGAACTGTTAGTTGGTTGTCAGTGAACAATAACTTTATT
ATATGAGTTTTTGTAGCATCTTAAGAATTATACATATGTTTGAAATATTGAAACTAAGCTACGGTACCAGTAATTAGATGTAGAATCTTG
TTTGTAGGCTGAATTTTAATCTGTATTTATTGTCTTTTGTATCTCAGAAATTAGAAACTTGCTACAGACTTACCCGTAATATTTGTCAAG
ATCATAGCTGACTTTAAAAACAGTTGTAATAAACTTTTTGATGCTAGCTGTTTACTGGTTTTTGTTTTTGATGTCATAAATAGACCTTGT
TTAATAGTCACAAGCCGTTGGGATATCATACCCAGCTGAAAAAGAACAAACTGCTTAACATAAGTATATGTATCGTAATAAGAGTTTTTT
ACCAGCTAAGTGATTCAATGTAAGTGGTTTTTAAAATAAAATACTGTAGAGATCA

>7539_7539_4_ATG16L2-TP53BP2_ATG16L2_chr11_72528900_ENST00000534905_TP53BP2_chr1_223980224_ENST00000343537_length(amino acids)=286AA_BP=106
MAGPGVPGAPAARWKRHIVRQLRLRDRTQKALFLELVPAYNHLLEKAELLDKFSKKLQPEPNSVTPTTHQGPWEESELDSDQVPSLVALR
VKWQEEEEGLRLVCGEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMT
YSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGVIYALWDYEPQNDDELPMKEGDCMTIIHREDEDEIEWWWARLNDKEGYVPRN
LLGLYPRIKPRQRSLA

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>7539_7539_5_ATG16L2-TP53BP2_ATG16L2_chr11_72528900_ENST00000534905_TP53BP2_chr1_223980224_ENST00000391878_length(transcript)=1855nt_BP=358nt
TGGGCGGGAGGAACGCGCCGCTAGGCGGGAGAGCGCGGCCATGGCGGGGCCGGGCGTCCCCGGTGCCCCCGCAGCGCGCTGGAAACGCCA
CATCGTGCGGCAGCTGCGGCTTCGGGACCGTACGCAAAAGGCGCTTTTCCTGGAGCTGGTGCCGGCCTATAACCATCTCTTAGAGAAGGC
TGAGCTGCTGGACAAGTTCTCAAAGAAGCTGCAGCCGGAGCCAAACAGTGTCACTCCCACCACCCACCAGGGCCCCTGGGAGGAGTCAGA
GCTTGACTCAGACCAAGTCCCATCACTGGTCGCACTGAGGGTGAAGTGGCAGGAGGAGGAGGAGGGGCTCCGGCTGGTCTGTGGTGAGGT
TGATGACCCAAGCCTCCCCAATGATGAAGGCATCACGGCTCTTCACAATGCTGTGTGTGCAGGCCACACAGAAATCGTTAAGTTCCTGGT
ACAGTTTGGTGTAAATGTAAATGCTGCTGATAGTGATGGATGGACTCCATTACATTGTGCTGCCTCATGTAACAACGTCCAAGTGTGTAA
GTTTTTGGTGGAGTCAGGAGCCGCTGTGTTTGCCATGACCTACAGTGACATGCAGACTGCTGCAGATAAGTGCGAGGAAATGGAGGAAGG
CTACACTCAGTGCTCCCAATTTCTTTATGGAGTTCAGGAGAAGATGGGCATAATGAATAAAGGAGTCATTTATGCGCTTTGGGATTATGA
ACCTCAGAATGATGATGAGCTGCCCATGAAAGAAGGAGACTGCATGACAATCATCCACAGGGAAGACGAAGATGAAATCGAATGGTGGTG
GGCGCGCCTTAATGATAAGGAGGGATATGTTCCACGTAACTTGCTGGGACTGTACCCAAGAATTAAACCAAGACAAAGGAGCTTGGCCTG
AAACTTCCACACAGAATTTTAGTCAATGAAGAATTAATCTCTGTTAAGAAGAAGTAATACGATTATTTTTGGCAAAAATTTCACAAGACT
TATTTTAATGACAATGTAGCTTGAAAGCGATGAAGAATGTCTCTAGAAGAGAATGAAGGATTGAAGAATTCACCATTAGAGGACATTTAG
CGTGATGAAATAAAGCATCTACGTCAGCAGGCCATACTGTGTTGGGGCAAAGGTGTCCCGTGTAGCACTCAGATAAGTATACAGCGACAA
TCCTGTTTTCTACAAGAATCCTGTCTAGTAAATAGGATCATTTATTGGGCAGTTGGGAAATCAGCTCTCTGTCCTGTTGAGTGTTTTCAG
CAGCTGCTCCTAAACCAGTCCTCCTGCCAGAAAGGACCAGTGCCGTCACATCGCTGTCTCTGATTGTCCCCGGCACCAGCAGGCCCTTGG
GGGGCTCACCTGAAGGCTCGAAGGCACTGCACACTTGTATATTGTCAGTGAAGAACTGTTAGTTGGTTGTCAGTGAACAATAACTTTATT
ATATGAGTTTTTGTAGCATCTTAAGAATTATACATATGTTTGAAATATTGAAACTAAGCTACGGTACCAGTAATTAGATGTAGAATCTTG
TTTGTAGGCTGAATTTTAATCTGTATTTATTGTCTTTTGTATCTCAGAAATTAGAAACTTGCTACAGACTTACCCGTAATATTTGTCAAG
ATCATAGCTGACTTTAAAAACAGTTGTAATAAACTTTTTGATGCTAGCTGTTTACTGGTTTTTGTTTTTGATGTCATAAATAGACCTTGT
TTAATAGTCACAAGCCGTTGGGATATCATACCCAGCTGAAAAAGAACAAACTGCTTAACATAAGTATATGTATCGTAATAAGAGTTTTTT
ACCAGCTAAGTGATTCAATGTAAGTGGTTTTTAAAATAAAATACTGTAGAGATCA

>7539_7539_5_ATG16L2-TP53BP2_ATG16L2_chr11_72528900_ENST00000534905_TP53BP2_chr1_223980224_ENST00000391878_length(amino acids)=286AA_BP=106
MAGPGVPGAPAARWKRHIVRQLRLRDRTQKALFLELVPAYNHLLEKAELLDKFSKKLQPEPNSVTPTTHQGPWEESELDSDQVPSLVALR
VKWQEEEEGLRLVCGEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMT
YSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGVIYALWDYEPQNDDELPMKEGDCMTIIHREDEDEIEWWWARLNDKEGYVPRN
LLGLYPRIKPRQRSLA

--------------------------------------------------------------
>7539_7539_6_ATG16L2-TP53BP2_ATG16L2_chr11_72528900_ENST00000534905_TP53BP2_chr1_223980224_ENST00000391879_length(transcript)=1109nt_BP=358nt
TGGGCGGGAGGAACGCGCCGCTAGGCGGGAGAGCGCGGCCATGGCGGGGCCGGGCGTCCCCGGTGCCCCCGCAGCGCGCTGGAAACGCCA
CATCGTGCGGCAGCTGCGGCTTCGGGACCGTACGCAAAAGGCGCTTTTCCTGGAGCTGGTGCCGGCCTATAACCATCTCTTAGAGAAGGC
TGAGCTGCTGGACAAGTTCTCAAAGAAGCTGCAGCCGGAGCCAAACAGTGTCACTCCCACCACCCACCAGGGCCCCTGGGAGGAGTCAGA
GCTTGACTCAGACCAAGTCCCATCACTGGTCGCACTGAGGGTGAAGTGGCAGGAGGAGGAGGAGGGGCTCCGGCTGGTCTGTGGTGAGGT
TGATGACCCAAGCCTCCCCAATGATGAAGGCATCACGGCTCTTCACAATGCTGTGTGTGCAGGCCACACAGAAATCGTTAAGTTCCTGGT
ACAGTTTGGTGTAAATGTAAATGCTGCTGATAGTGATGGATGGACTCCATTACATTGTGCTGCCTCATGTAACAACGTCCAAGTGTGTAA
GTTTTTGGTGGAGTCAGGAGCCGCTGTGTTTGCCATGACCTACAGTGACATGCAGACTGCTGCAGATAAGTGCGAGGAAATGGAGGAAGG
CTACACTCAGTGCTCCCAATTTCTTTATGGAGTTCAGGAGAAGATGGGCATAATGAATAAAGGAGTCATTTATGCGCTTTGGGATTATGA
ACCTCAGAATGATGATGAGCTGCCCATGAAAGAAGGAGACTGCATGACAATCATCCACAGGGAAGACGAAGATGAAATCGAATGGTGGTG
GGCGCGCCTTAATGATAAGGAGGGATATGTTCCACGTAACTTGCTGGGACTGTACCCAAGAATTAAACCAAGACAAAGGAGCTTGGCCTG
AAACTTCCACACAGAATTTTAGTCAATGAAGAATTAATCTCTGTTAAGAAGAAGTAATACGATTATTTTTGGCAAAAATTTCACAAGACT
TATTTTAATGACAATGTAGCTTGAAAGCGATGAAGAATGTCTCTAGAAGAGAATGAAGGATTGAAGAATTCACCATTAGAGGACATTTAG
CGTGATGAAATAAAGCATCTACGTCAGCA

>7539_7539_6_ATG16L2-TP53BP2_ATG16L2_chr11_72528900_ENST00000534905_TP53BP2_chr1_223980224_ENST00000391879_length(amino acids)=286AA_BP=106
MAGPGVPGAPAARWKRHIVRQLRLRDRTQKALFLELVPAYNHLLEKAELLDKFSKKLQPEPNSVTPTTHQGPWEESELDSDQVPSLVALR
VKWQEEEEGLRLVCGEVDDPSLPNDEGITALHNAVCAGHTEIVKFLVQFGVNVNAADSDGWTPLHCAASCNNVQVCKFLVESGAAVFAMT
YSDMQTAADKCEEMEEGYTQCSQFLYGVQEKMGIMNKGVIYALWDYEPQNDDELPMKEGDCMTIIHREDEDEIEWWWARLNDKEGYVPRN
LLGLYPRIKPRQRSLA

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Fusion Gene PPI Analysis for ATG16L2-TP53BP2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneTP53BP2chr11:72528900chr1:223980224ENST000003435371318332_348954.01135.0APPBP1
TgeneTP53BP2chr11:72528900chr1:223980224ENST000003918781419332_348825.01006.0APPBP1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ATG16L2-TP53BP2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ATG16L2-TP53BP2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0027626Neoplasm Invasiveness1CTD_human
TgeneC0206692Carcinoma, Lobular1CTD_human
TgeneC0339573Glaucoma, Primary Open Angle1GENOMICS_ENGLAND
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human