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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:TAF1C-ARAF (FusionGDB2 ID:HG9013TG369) |
Fusion Gene Summary for TAF1C-ARAF |
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Fusion gene information | Fusion gene name: TAF1C-ARAF | Fusion gene ID: hg9013tg369 | Hgene | Tgene | Gene symbol | TAF1C | ARAF | Gene ID | 9013 | 369 |
Gene name | TATA-box binding protein associated factor, RNA polymerase I subunit C | A-Raf proto-oncogene, serine/threonine kinase | |
Synonyms | MGC:39976|SL1|TAFI110|TAFI95 | A-RAF|ARAF1|PKS2|RAFA1 | |
Cytomap | ('TAF1C')('ARAF') 16q24.1 | Xp11.3 | |
Type of gene | protein-coding | protein-coding | |
Description | TATA box-binding protein-associated factor RNA polymerase I subunit CRNA polymerase I-specific TBP-associated factor 110 kDaSL1, 110kD subunitTATA box binding protein (TBP)-associated factor, RNA polymerase I, C, 110kDTATA box binding protein (TBP)-as | serine/threonine-protein kinase A-RafA-Raf proto-oncogene serine/threonine-protein kinaseOncogene ARAF1Ras-binding protein DA-Rafproto-oncogene A-Raf-1proto-oncogene Pksv-raf murine sarcoma 3611 viral oncogene homolog 1v-raf murine sarcoma 3611 vir | |
Modification date | 20200320 | 20200327 | |
UniProtAcc | . | . | |
Ensembl transtripts involved in fusion gene | ENST00000341690, ENST00000378541, ENST00000541676, ENST00000566732, ENST00000567759, ENST00000570117, ENST00000565544, | ||
Fusion gene scores | * DoF score | 2 X 1 X 2=4 | 3 X 3 X 3=27 |
# samples | 2 | 3 | |
** MAII score | log2(2/4*10)=2.32192809488736 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context | PubMed: TAF1C [Title/Abstract] AND ARAF [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | TAF1C(84215807)-ARAF(47428937), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | TAF1C-ARAF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TAF1C-ARAF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. TAF1C-ARAF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TAF1C-ARAF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. TAF1C-ARAF seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. TAF1C-ARAF seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. TAF1C-ARAF seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. TAF1C-ARAF seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ARAF | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19667065 |
Tgene | ARAF | GO:0043066 | negative regulation of apoptotic process | 19667065 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | STAD | TCGA-FP-A8CX | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
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Fusion Gene ORF analysis for TAF1C-ARAF |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000341690 | ENST00000290277 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
5CDS-intron | ENST00000341690 | ENST00000377039 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
5CDS-intron | ENST00000341690 | ENST00000470206 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
5CDS-intron | ENST00000378541 | ENST00000290277 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
5CDS-intron | ENST00000378541 | ENST00000377039 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
5CDS-intron | ENST00000378541 | ENST00000470206 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
5CDS-intron | ENST00000541676 | ENST00000290277 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
5CDS-intron | ENST00000541676 | ENST00000377039 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
5CDS-intron | ENST00000541676 | ENST00000470206 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
5CDS-intron | ENST00000566732 | ENST00000290277 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
5CDS-intron | ENST00000566732 | ENST00000377039 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
5CDS-intron | ENST00000566732 | ENST00000470206 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
5CDS-intron | ENST00000567759 | ENST00000290277 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
5CDS-intron | ENST00000567759 | ENST00000377039 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
5CDS-intron | ENST00000567759 | ENST00000470206 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
5UTR-3CDS | ENST00000570117 | ENST00000377045 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
5UTR-intron | ENST00000570117 | ENST00000290277 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
5UTR-intron | ENST00000570117 | ENST00000377039 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
5UTR-intron | ENST00000570117 | ENST00000470206 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
Frame-shift | ENST00000341690 | ENST00000377045 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
Frame-shift | ENST00000541676 | ENST00000377045 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
Frame-shift | ENST00000566732 | ENST00000377045 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
Frame-shift | ENST00000567759 | ENST00000377045 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
In-frame | ENST00000378541 | ENST00000377045 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
intron-3CDS | ENST00000565544 | ENST00000377045 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
intron-intron | ENST00000565544 | ENST00000290277 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
intron-intron | ENST00000565544 | ENST00000377039 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
intron-intron | ENST00000565544 | ENST00000470206 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000378541 | TAF1C | chr16 | 84215807 | - | ENST00000377045 | ARAF | chrX | 47428937 | + | 1685 | 721 | 0 | 1241 | 413 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000378541 | ENST00000377045 | TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + | 0.08064351 | 0.9193565 |
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Fusion Genomic Features for TAF1C-ARAF |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + | 0.99090415 | 0.009095822 |
TAF1C | chr16 | 84215807 | - | ARAF | chrX | 47428937 | + | 0.99090415 | 0.009095822 |
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Fusion Protein Features for TAF1C-ARAF |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:84215807/chrX:47428937) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | . |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | ARAF | chr16:84215807 | chrX:47428937 | ENST00000377039 | 0 | 6 | 19_91 | 0 | 187.0 | Domain | RBD | |
Tgene | ARAF | chr16:84215807 | chrX:47428937 | ENST00000377039 | 0 | 6 | 310_570 | 0 | 187.0 | Domain | Protein kinase | |
Tgene | ARAF | chr16:84215807 | chrX:47428937 | ENST00000377039 | 0 | 6 | 316_324 | 0 | 187.0 | Nucleotide binding | ATP | |
Tgene | ARAF | chr16:84215807 | chrX:47428937 | ENST00000377039 | 0 | 6 | 98_144 | 0 | 187.0 | Zinc finger | Phorbol-ester/DAG-type |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | ARAF | chr16:84215807 | chrX:47428937 | ENST00000377045 | 11 | 16 | 19_91 | 433 | 607.0 | Domain | RBD | |
Tgene | ARAF | chr16:84215807 | chrX:47428937 | ENST00000377045 | 11 | 16 | 310_570 | 433 | 607.0 | Domain | Protein kinase | |
Tgene | ARAF | chr16:84215807 | chrX:47428937 | ENST00000377045 | 11 | 16 | 316_324 | 433 | 607.0 | Nucleotide binding | ATP | |
Tgene | ARAF | chr16:84215807 | chrX:47428937 | ENST00000377045 | 11 | 16 | 98_144 | 433 | 607.0 | Zinc finger | Phorbol-ester/DAG-type |
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Fusion Gene Sequence for TAF1C-ARAF |
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>88748_88748_1_TAF1C-ARAF_TAF1C_chr16_84215807_ENST00000378541_ARAF_chrX_47428937_ENST00000377045_length(transcript)=1685nt_BP=721nt ATGGACTTCCCCAGCTCCCTCCGCCCTGCATTGTTTCTGACCGGCCCCCTTGGTCTGAGCGACGTCCCTGACCTCTCTTTCATGTGCAGC TGGCGAGACGCACTGACTCTGCCAGAGGCCCAGCCCCAGAACTCAGAGAATGGGGCACTGCATGTGACCAAGGACCTGCTGTGGGAGCCG GCAACCCCTGGGCCTCTCCCCATGCTGCCTCCCCTCATCGATCCCTGGGACCCTGGCCTGACTGCCCGGGACCTGCTTTTCCGCGGAGGG TGCCGGTATCGGAAGCGGCCCCGAGTCGTGCTGGATGTGACTGAGCAGATCAGCCGGTTCCTCTTGGATCATGGAGACGTAGCCTTTGCG CCCCTGGGGAAGCTGATGCTGGAGAATTTCAAGCTGGAGGGAGCGGGGAGCCGCACTAAGAAGAAGACAGTGGTCAGTGTGAAGAAGCTG CTCCAGGACCTCGGTGGACACCAGCCCTGGGGGTGTCCCTGGGCTTACCTCAGCAACCGACAGCGCCGCTTCTCTATCCTCGGGGGCCCC ATCCTGGGCACGTCGGTGGCGAGCCACTTGGCAGAGCTGCTGCACGAGGAGCTGGTGCTGCGGTGGGAGCAGCTGCTTCTGGATGAGGCC TGCACTGGGGGCGCGCTGGCCTGGGTTCCTGGAAGGACACCCCAGTTCGGGCAGCTGGTCTACCCTGCTGGAGGCGCCCAGGACAGGCTG CACATCTTCCTACATGAGGGGCTCACGGTGAAGATCGGTGACTTTGGCTTGGCCACAGTGAAGACTCGATGGAGCGGGGCCCAGCCCTTG GAGCAGCCCTCAGGATCTGTGCTGTGGATGGCAGCTGAGGTGATCCGTATGCAGGACCCGAACCCCTACAGCTTCCAGTCAGACGTCTAT GCCTACGGGGTTGTGCTCTACGAGCTTATGACTGGCTCACTGCCTTACAGCCACATTGGCTGCCGTGACCAGATTATCTTTATGGTGGGC CGTGGCTATCTGTCCCCGGACCTCAGCAAAATCTCCAGCAACTGCCCCAAGGCCATGCGGCGCCTGCTGTCTGACTGCCTCAAGTTCCAG CGGGAGGAGCGGCCCCTCTTCCCCCAGATCCTGGCCACAATTGAGCTGCTGCAACGGTCACTCCCCAAGATTGAGCGGAGTGCCTCGGAA CCCTCCTTGCACCGCACCCAGGCCGATGAGTTGCCTGCCTGCCTACTCAGCGCAGCCCGCCTTGTGCCTTAGGCCCCGCCCAAGCCACCA GGGAGCCAATCTCAGCCCTCCACGCCAAGGAGCCTTGCCCACCAGCCAATCAATGTTCGTCTCTGCCCTGATGCTGCCTCAGGATCCCCC ATTCCCCACCCTGGGAGATGAGGGGGTCCCCATGTGCTTTTCCAGTTCTTCTGGAATTGGGGGACCCCCGCCAAAGACTGAGCCCCCTGT CTCCTCCATCATTTGGTTTCCTCTTGGCTTTGGGGATACTTCTAAATTTTGGGAGCTCCTCCATCTCCAATGGCTGGGATTTGTGGCAGG GATTCCACTCAGAACCTCTCTGGAATTTGTGCCTGATGTGCCTTCCACTGGATTTTGGGGTTCCCAGCACCCCATGTGGATTTTGGGGGG TCCCTTTTGTGTCTCCCCCGCCATTCAAGGACTCCTCTCTTTCTTCACCAAGAAGCACAGAATTC >88748_88748_1_TAF1C-ARAF_TAF1C_chr16_84215807_ENST00000378541_ARAF_chrX_47428937_ENST00000377045_length(amino acids)=413AA_BP=241 MDFPSSLRPALFLTGPLGLSDVPDLSFMCSWRDALTLPEAQPQNSENGALHVTKDLLWEPATPGPLPMLPPLIDPWDPGLTARDLLFRGG CRYRKRPRVVLDVTEQISRFLLDHGDVAFAPLGKLMLENFKLEGAGSRTKKKTVVSVKKLLQDLGGHQPWGCPWAYLSNRQRRFSILGGP ILGTSVASHLAELLHEELVLRWEQLLLDEACTGGALAWVPGRTPQFGQLVYPAGGAQDRLHIFLHEGLTVKIGDFGLATVKTRWSGAQPL EQPSGSVLWMAAEVIRMQDPNPYSFQSDVYAYGVVLYELMTGSLPYSHIGCRDQIIFMVGRGYLSPDLSKISSNCPKAMRRLLSDCLKFQ REERPLFPQILATIELLQRSLPKIERSASEPSLHRTQADELPACLLSAARLVP -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for TAF1C-ARAF |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for TAF1C-ARAF |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for TAF1C-ARAF |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | TAF1C | C0004352 | Autistic Disorder | 1 | CTD_human |
Tgene | C0006142 | Malignant neoplasm of breast | 1 | CTD_human | |
Tgene | C0678222 | Breast Carcinoma | 1 | CTD_human | |
Tgene | C1257931 | Mammary Neoplasms, Human | 1 | CTD_human | |
Tgene | C1458155 | Mammary Neoplasms | 1 | CTD_human | |
Tgene | C4704874 | Mammary Carcinoma, Human | 1 | CTD_human |