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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:HS6ST2-NPFFR2 (FusionGDB2 ID:HG90161TG10886)

Fusion Gene Summary for HS6ST2-NPFFR2

check button Fusion gene summary
Fusion gene informationFusion gene name: HS6ST2-NPFFR2
Fusion gene ID: hg90161tg10886
HgeneTgene
Gene symbol

HS6ST2

NPFFR2

Gene ID

90161

10886

Gene nameheparan sulfate 6-O-sulfotransferase 2neuropeptide FF receptor 2
SynonymsMRXSPMGPR74|HLWAR77|NPFF2|NPGPR
Cytomap('HS6ST2')('NPFFR2')

Xq26.2

4q13.3

Type of geneprotein-codingprotein-coding
Descriptionheparan-sulfate 6-O-sulfotransferase 2HS6ST-2neuropeptide FF receptor 2G-protein coupled receptor 74G-protein coupled receptor HLWAR77neuropeptide FF 2neuropeptide G-protein coupled receptor
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000370833, ENST00000370836, 
ENST00000521489, ENST00000406696, 
ENST00000602570, 
Fusion gene scores* DoF score3 X 3 X 2=182 X 3 X 2=12
# samples 33
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: HS6ST2 [Title/Abstract] AND NPFFR2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointHS6ST2(132090836)-NPFFR2(73003757), # samples:1
Anticipated loss of major functional domain due to fusion event.HS6ST2-NPFFR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HS6ST2-NPFFR2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HS6ST2-NPFFR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HS6ST2-NPFFR2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HS6ST2-NPFFR2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
HS6ST2-NPFFR2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across HS6ST2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across NPFFR2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-BT-A2LD-01AHS6ST2chrX

132090836

-NPFFR2chr4

73003757

+


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Fusion Gene ORF analysis for HS6ST2-NPFFR2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000370833ENST00000506359HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
5CDS-intronENST00000370836ENST00000506359HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
5CDS-intronENST00000521489ENST00000506359HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
Frame-shiftENST00000370833ENST00000308744HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
Frame-shiftENST00000370833ENST00000358749HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
Frame-shiftENST00000370833ENST00000395999HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
Frame-shiftENST00000370836ENST00000344413HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
Frame-shiftENST00000521489ENST00000344413HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
In-frameENST00000370833ENST00000344413HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
In-frameENST00000370836ENST00000308744HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
In-frameENST00000370836ENST00000358749HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
In-frameENST00000370836ENST00000395999HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
In-frameENST00000521489ENST00000308744HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
In-frameENST00000521489ENST00000358749HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
In-frameENST00000521489ENST00000395999HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
intron-3CDSENST00000406696ENST00000308744HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
intron-3CDSENST00000406696ENST00000344413HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
intron-3CDSENST00000406696ENST00000358749HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
intron-3CDSENST00000406696ENST00000395999HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
intron-3CDSENST00000602570ENST00000308744HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
intron-3CDSENST00000602570ENST00000344413HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
intron-3CDSENST00000602570ENST00000358749HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
intron-3CDSENST00000602570ENST00000395999HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
intron-intronENST00000406696ENST00000506359HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+
intron-intronENST00000602570ENST00000506359HS6ST2chrX

132090836

-NPFFR2chr4

73003757

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000370836HS6ST2chrX132090836-ENST00000308744NPFFR2chr473003757+255313633171462381
ENST00000370836HS6ST2chrX132090836-ENST00000395999NPFFR2chr473003757+254713633171462381
ENST00000370836HS6ST2chrX132090836-ENST00000358749NPFFR2chr473003757+254713633171462381
ENST00000521489HS6ST2chrX132090836-ENST00000308744NPFFR2chr473003757+255313633171462381
ENST00000521489HS6ST2chrX132090836-ENST00000395999NPFFR2chr473003757+254713633171462381
ENST00000521489HS6ST2chrX132090836-ENST00000358749NPFFR2chr473003757+254713633171462381
ENST00000370833HS6ST2chrX132090836-ENST00000344413NPFFR2chr473003757+14445095291443305

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000370836ENST00000308744HS6ST2chrX132090836-NPFFR2chr473003757+0.353184430.64681554
ENST00000370836ENST00000395999HS6ST2chrX132090836-NPFFR2chr473003757+0.35204780.6479522
ENST00000370836ENST00000358749HS6ST2chrX132090836-NPFFR2chr473003757+0.35204780.6479522
ENST00000521489ENST00000308744HS6ST2chrX132090836-NPFFR2chr473003757+0.353184430.64681554
ENST00000521489ENST00000395999HS6ST2chrX132090836-NPFFR2chr473003757+0.35204780.6479522
ENST00000521489ENST00000358749HS6ST2chrX132090836-NPFFR2chr473003757+0.35204780.6479522
ENST00000370833ENST00000344413HS6ST2chrX132090836-NPFFR2chr473003757+0.0124338470.9875661

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Fusion Genomic Features for HS6ST2-NPFFR2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
HS6ST2chrX132090835-NPFFR2chr473003756+0.0011302670.9988697
HS6ST2chrX132090835-NPFFR2chr473003756+0.0011302670.9988697

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for HS6ST2-NPFFR2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:132090836/chr4:73003757)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHS6ST2chrX:132090836chr4:73003757ENST00000370836-34233_241315606.0RegionPAPS binding
HgeneHS6ST2chrX:132090836chr4:73003757ENST00000370836-34263_264315606.0RegionSubstrate binding
HgeneHS6ST2chrX:132090836chr4:73003757ENST00000521489-36233_241315646.0RegionPAPS binding
HgeneHS6ST2chrX:132090836chr4:73003757ENST00000521489-36263_264315646.0RegionSubstrate binding
HgeneHS6ST2chrX:132090836chr4:73003757ENST00000370836-341_4315606.0Topological domainCytoplasmic
HgeneHS6ST2chrX:132090836chr4:73003757ENST00000521489-361_4315646.0Topological domainCytoplasmic
HgeneHS6ST2chrX:132090836chr4:73003757ENST00000370836-345_27315606.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
HgeneHS6ST2chrX:132090836chr4:73003757ENST00000521489-365_27315646.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000030874414243_262211523.0Topological domainCytoplasmic
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000030874414284_319211523.0Topological domainExtracellular
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000030874414341_377211523.0Topological domainCytoplasmic
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000030874414399_413211523.0Topological domainExtracellular
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000030874414435_522211523.0Topological domainCytoplasmic
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000034441303169_18499311.6666666666667Topological domainCytoplasmic
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000034441303206_22199311.6666666666667Topological domainExtracellular
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000034441303243_26299311.6666666666667Topological domainCytoplasmic
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000034441303284_31999311.6666666666667Topological domainExtracellular
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000034441303341_37799311.6666666666667Topological domainCytoplasmic
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000034441303399_41399311.6666666666667Topological domainExtracellular
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000034441303435_52299311.6666666666667Topological domainCytoplasmic
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000035874914169_184109421.0Topological domainCytoplasmic
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000035874914206_221109421.0Topological domainExtracellular
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000035874914243_262109421.0Topological domainCytoplasmic
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000035874914284_319109421.0Topological domainExtracellular
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000035874914341_377109421.0Topological domainCytoplasmic
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000035874914399_413109421.0Topological domainExtracellular
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000035874914435_522109421.0Topological domainCytoplasmic
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000039599925169_184112424.0Topological domainCytoplasmic
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000039599925206_221112424.0Topological domainExtracellular
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000039599925243_262112424.0Topological domainCytoplasmic
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000039599925284_319112424.0Topological domainExtracellular
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000039599925341_377112424.0Topological domainCytoplasmic
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000039599925399_413112424.0Topological domainExtracellular
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000039599925435_522112424.0Topological domainCytoplasmic
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000030874414222_242211523.0TransmembraneHelical%3B Name%3D3
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000030874414263_283211523.0TransmembraneHelical%3B Name%3D4
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000030874414320_340211523.0TransmembraneHelical%3B Name%3D5
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000030874414378_398211523.0TransmembraneHelical%3B Name%3D6
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000030874414414_434211523.0TransmembraneHelical%3B Name%3D7
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000034441303148_16899311.6666666666667TransmembraneHelical%3B Name%3D1
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000034441303185_20599311.6666666666667TransmembraneHelical%3B Name%3D2
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000034441303222_24299311.6666666666667TransmembraneHelical%3B Name%3D3
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000034441303263_28399311.6666666666667TransmembraneHelical%3B Name%3D4
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000034441303320_34099311.6666666666667TransmembraneHelical%3B Name%3D5
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000034441303378_39899311.6666666666667TransmembraneHelical%3B Name%3D6
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000034441303414_43499311.6666666666667TransmembraneHelical%3B Name%3D7
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000035874914148_168109421.0TransmembraneHelical%3B Name%3D1
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000035874914185_205109421.0TransmembraneHelical%3B Name%3D2
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000035874914222_242109421.0TransmembraneHelical%3B Name%3D3
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000035874914263_283109421.0TransmembraneHelical%3B Name%3D4
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000035874914320_340109421.0TransmembraneHelical%3B Name%3D5
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000035874914378_398109421.0TransmembraneHelical%3B Name%3D6
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000035874914414_434109421.0TransmembraneHelical%3B Name%3D7
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000039599925148_168112424.0TransmembraneHelical%3B Name%3D1
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000039599925185_205112424.0TransmembraneHelical%3B Name%3D2
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000039599925222_242112424.0TransmembraneHelical%3B Name%3D3
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000039599925263_283112424.0TransmembraneHelical%3B Name%3D4
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000039599925320_340112424.0TransmembraneHelical%3B Name%3D5
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000039599925378_398112424.0TransmembraneHelical%3B Name%3D6
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000039599925414_434112424.0TransmembraneHelical%3B Name%3D7

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHS6ST2chrX:132090836chr4:73003757ENST00000370836-34457_459315606.0RegionPAPS binding
HgeneHS6ST2chrX:132090836chr4:73003757ENST00000370836-34463_464315606.0RegionPAPS binding
HgeneHS6ST2chrX:132090836chr4:73003757ENST00000521489-36457_459315646.0RegionPAPS binding
HgeneHS6ST2chrX:132090836chr4:73003757ENST00000521489-36463_464315646.0RegionPAPS binding
HgeneHS6ST2chrX:132090836chr4:73003757ENST00000370836-3428_605315606.0Topological domainLumenal
HgeneHS6ST2chrX:132090836chr4:73003757ENST00000521489-3628_605315646.0Topological domainLumenal
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000030874414169_184211523.0Topological domainCytoplasmic
TgeneNPFFR2chrX:132090836chr4:73003757ENST00000308744141_147211523.0Topological domainExtracellular
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000030874414206_221211523.0Topological domainExtracellular
TgeneNPFFR2chrX:132090836chr4:73003757ENST00000344413031_14799311.6666666666667Topological domainExtracellular
TgeneNPFFR2chrX:132090836chr4:73003757ENST00000358749141_147109421.0Topological domainExtracellular
TgeneNPFFR2chrX:132090836chr4:73003757ENST00000395999251_147112424.0Topological domainExtracellular
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000030874414148_168211523.0TransmembraneHelical%3B Name%3D1
TgeneNPFFR2chrX:132090836chr4:73003757ENST0000030874414185_205211523.0TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for HS6ST2-NPFFR2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>37618_37618_1_HS6ST2-NPFFR2_HS6ST2_chrX_132090836_ENST00000370833_NPFFR2_chr4_73003757_ENST00000344413_length(transcript)=1444nt_BP=509nt
ATGGATGAGAAATCCAACAAGCTGCTGCTAGCTTTGGTGATGCTCTTCCTATTTGCCGTGATCGTCCTCCAATACGTGTGCCCCGGCACA
GAATGCCAGCTCCTCCGCCTGCAGGCGTTCAGCTCCCCGGTGCCGGACCCGTACCGCTCGGAGGATGAGAGCTCCGCCAGGTTCGTGCCC
CGCTACAATTTCACCCGCGGCGACCTCCTGCGCAAGGTAGACTTCGACATCAAGGGCGATGACCTGATCGTGTTCCTGCACATCCAGAAG
ACCGGGGGCACCACTTTCGGCCGCCACTTGGTGCGTAACATCCAGCTGGAGCAGCCGTGCGAGTGCCGCGTGGGTCAGAAGAAATGCACT
TGCCACCGGCCGGGTAAGCGGGAAACCTGGCTCTTCTCCAGGTTCTCCACGGGCTGGAGCTGCGGGTTGCACGCCGACTGGACCGAGCTC
ACCAGCTGTGTGCCCTCCGTGGTGGACGGCAAGCGCGACGCCAGGCTGAGACCGTCCAGGATGGCCATTTGGAAACACGATGTGCAAGAT
CAGTGGATTGGTCCAGGGAATATCTGTCGCAGCTTCAGTCTTTACGTTAGTTGCAATTGCTGTAGATAGGTTCCAGTGTGTGGTCTACCC
TTTTAAACCAAAGCTCACTATCAAGACAGCGTTTGTCATTATTATGATCATCTGGGTCCTAGCCATCACCATTATGTCTCCATCTGCAGT
AATGTTACATGTGCAAGAAGAAAAATATTACCGAGTGAGACTCAACTCCCAGAATAAAACCAGTCCAGTCTACTGGTGCCGGGAAGACTG
GCCAAATCAGGAAATGAGGAAGATCTACACCACTGTGCTGTTTGCCAACATCTACCTGGCTCCCCTCTCCCTCATTGTCATCATGTATGG
AAGGATTGGAATTTCACTCTTCAGGGCTGCAGTTCCTCACACAGGCAGGAAGAACCAGGAGCAGTGGCACGTGGTGTCCAGGAAGAAGCA
GAAGATCATTAAGATGCTCCTGATTGTGGCCCTGCTTTTTATTCTCTCATGGCTGCCCCTGTGGACTCTAATGATGCTCTCAGACTACGC
TGACCTTTCTCCAAATGAACTGCAGATCATCAACATCTACATCTACCCTTTTGCACACTGGCTGGCATTCGGCAACAGCAGTGTCAATCC
CATCATTTATGGTTTCTTCAACGAGAATTTCCGCCGTGGTTTCCAAGAAGCTTTCCAGCTCCAGCTCTGCCAAAAAAGAGCAAAGCCTAT
GGAAGCTTATGCCCTAAAAGCTAAAAGCCATGTGCTCATAAACACATCTAATCAGCTTGTCCAGGAATCTACATTTCAAAACCCTCATGG
GGAAACCTTGCTTTATAGGAAAAGTGCTGAAAAACCCCAACAGGAATTAGTGATGGAAGAATTAAAAGAAACTACTAACAGCAGTGAGAT
TTAA

>37618_37618_1_HS6ST2-NPFFR2_HS6ST2_chrX_132090836_ENST00000370833_NPFFR2_chr4_73003757_ENST00000344413_length(amino acids)=305AA_BP=
MCKISGLVQGISVAASVFTLVAIAVDRFQCVVYPFKPKLTIKTAFVIIMIIWVLAITIMSPSAVMLHVQEEKYYRVRLNSQNKTSPVYWC
REDWPNQEMRKIYTTVLFANIYLAPLSLIVIMYGRIGISLFRAAVPHTGRKNQEQWHVVSRKKQKIIKMLLIVALLFILSWLPLWTLMML
SDYADLSPNELQIINIYIYPFAHWLAFGNSSVNPIIYGFFNENFRRGFQEAFQLQLCQKRAKPMEAYALKAKSHVLINTSNQLVQESTFQ
NPHGETLLYRKSAEKPQQELVMEELKETTNSSEIX

--------------------------------------------------------------
>37618_37618_2_HS6ST2-NPFFR2_HS6ST2_chrX_132090836_ENST00000370836_NPFFR2_chr4_73003757_ENST00000308744_length(transcript)=2553nt_BP=1363nt
AAGCCAGGCTGACCTTTATGCTCCCAGAATCATCAGCCTTTTCATTGGAAACCATGGAAGGACGGTTCTGGGAAAATAATGAAAATCATA
CCACACCATAGAGACAACCAGAAGCCCTGCTCAGATGACAGAGTTCTCCTCGCCTTCCAGAAAATGCCCCCGCTTCCGCTGGAGAATGGA
AATTGGCAAAGAGAGACGGAAAAGCTCCAATTTGCGCCTTTGCTATTTTAGGAGAGGTTGAAATTACGAGCCAAAGTGGAGTGATGCGCT
AAGCGGAGTGACCTCCGTACTCCAAGAAAAGAGAAAACCCAGGTTCTCTGCTTGTGAAGTGGCTCGAGCTCTTAGGCGTGAGGCATTATT
ATATAAATTCAAGCTCGCTCGTGATCCTTAGTACCCTGAGTTGCCTGAAGGGGGGAATGGCACTGCCTGCGTGTGCAGTCCGGGAGTTCG
AGCCGCCGCGGCAACCGGAGCGAGGAGCGCCCGTCCGCACCACCTGTCCCCGCCGGCATTCCAGAGTAGAGGCCGAATTGGCAGCGAGCC
GGCCCGGGTCGGTCGCCGCCTCAGTTCGCGCGGGCCCTCCTAGGGGTGTGTCTCACGGATTCCACACCCGGCCGCTCCTGGACAAGCCCC
GAAAGGCGTCTTCTTCCCTGGCGGGAGCCGCGTGCGCCCCGCTTTTCGCGCTGCTGTCCCGGGGCCGCCGCAGGCGGATGCACGTCCTCA
GGCGACGCTGGGACCTGGGCTCCCTCTGCCGGGCCCTGCTCACTCGGGGCCTGGCCGCCCTGGGCCACTCGCTGAAGCACGTGCTCGGTG
CGATCTTCTCCAAGATTTTCGGCCCCATGGCCAGCGTCGGGAACATGGATGAGAAATCCAACAAGCTGCTGCTAGCTTTGGTGATGCTCT
TCCTATTTGCCGTGATCGTCCTCCAATACGTGTGCCCCGGCACAGAATGCCAGCTCCTCCGCCTGCAGGCGTTCAGCTCCCCGGTGCCGG
ACCCGTACCGCTCGGAGGATGAGAGCTCCGCCAGGTTCGTGCCCCGCTACAATTTCACCCGCGGCGACCTCCTGCGCAAGGTAGACTTCG
ACATCAAGGGCGATGACCTGATCGTGTTCCTGCACATCCAGAAGACCGGGGGCACCACTTTCGGCCGCCACTTGGTGCGTAACATCCAGC
TGGAGCAGCCGTGCGAGTGCCGCGTGGGTCAGAAGAAATGCACTTGCCACCGGCCGGGTAAGCGGGAAACCTGGCTCTTCTCCAGGTTCT
CCACGGGCTGGAGCTGCGGGTTGCACGCCGACTGGACCGAGCTCACCAGCTGTGTGCCCTCCGTGGTGGACGGCAAGCGCGACGCCAGGC
TGAGACCGTCCAGGATGGCCATTTGGAAACACGATGTGCAAGATCAGTGGATTGGTCCAGGGAATATCTGTCGCAGCTTCAGTCTTTACG
TTAGTTGCAATTGCTGTAGATAGGTTCCAGTGTGTGGTCTACCCTTTTAAACCAAAGCTCACTATCAAGACAGCGTTTGTCATTATTATG
ATCATCTGGGTCCTAGCCATCACCATTATGTCTCCATCTGCAGTAATGTTACATGTGCAAGAAGAAAAATATTACCGAGTGAGACTCAAC
TCCCAGAATAAAACCAGTCCAGTCTACTGGTGCCGGGAAGACTGGCCAAATCAGGAAATGAGGAAGATCTACACCACTGTGCTGTTTGCC
AACATCTACCTGGCTCCCCTCTCCCTCATTGTCATCATGTATGGAAGGATTGGAATTTCACTCTTCAGGGCTGCAGTTCCTCACACAGGC
AGGAAGAACCAGGAGCAGTGGCACGTGGTGTCCAGGAAGAAGCAGAAGATCATTAAGATGCTCCTGATTGTGGCCCTGCTTTTTATTCTC
TCATGGCTGCCCCTGTGGACTCTAATGATGCTCTCAGACTACGCTGACCTTTCTCCAAATGAACTGCAGATCATCAACATCTACATCTAC
CCTTTTGCACACTGGCTGGCATTCGGCAACAGCAGTGTCAATCCCATCATTTATGGTTTCTTCAACGAGAATTTCCGCCGTGGTTTCCAA
GAAGCTTTCCAGCTCCAGCTCTGCCAAAAAAGAGCAAAGCCTATGGAAGCTTATGCCCTAAAAGCTAAAAGCCATGTGCTCATAAACACA
TCTAATCAGCTTGTCCAGGAATCTACATTTCAAAACCCTCATGGGGAAACCTTGCTTTATAGGAAAAGTGCTGAAAAACCCCAACAGGAA
TTAGTGATGGAAGAATTAAAAGAAACTACTAACAGCAGTGAGATTTAAAAAGAGCTAGTGTGATAATCCTAACTCTACTACGCATTATAT
ATTTAAATCCATTGCTTTTTGTGGCTTTGCACTTCAAATTTTTCAAAGAATGTTCTAAATAAAACATTTACTGAAAGCCCTCTCTGGCAA
AAAAATTAAAAATAAACAAAAATGGTCATAAGATCATAAACAATCTTATGTTGTATAAAAATACGTAGAGTGACTTAGACATGTTTGCAT
GAATAAATATATTTCTAGAGAACAGTTTACAAA

>37618_37618_2_HS6ST2-NPFFR2_HS6ST2_chrX_132090836_ENST00000370836_NPFFR2_chr4_73003757_ENST00000308744_length(amino acids)=381AA_BP=346
MLVKWLELLGVRHYYINSSSLVILSTLSCLKGGMALPACAVREFEPPRQPERGAPVRTTCPRRHSRVEAELAASRPGSVAASVRAGPPRG
VSHGFHTRPLLDKPRKASSSLAGAACAPLFALLSRGRRRRMHVLRRRWDLGSLCRALLTRGLAALGHSLKHVLGAIFSKIFGPMASVGNM
DEKSNKLLLALVMLFLFAVIVLQYVCPGTECQLLRLQAFSSPVPDPYRSEDESSARFVPRYNFTRGDLLRKVDFDIKGDDLIVFLHIQKT
GGTTFGRHLVRNIQLEQPCECRVGQKKCTCHRPGKRETWLFSRFSTGWSCGLHADWTELTSCVPSVVDGKRDARLRPSRMAIWKHDVQDQ
WIGPGNICRSFSLYVSCNCCR

--------------------------------------------------------------
>37618_37618_3_HS6ST2-NPFFR2_HS6ST2_chrX_132090836_ENST00000370836_NPFFR2_chr4_73003757_ENST00000358749_length(transcript)=2547nt_BP=1363nt
AAGCCAGGCTGACCTTTATGCTCCCAGAATCATCAGCCTTTTCATTGGAAACCATGGAAGGACGGTTCTGGGAAAATAATGAAAATCATA
CCACACCATAGAGACAACCAGAAGCCCTGCTCAGATGACAGAGTTCTCCTCGCCTTCCAGAAAATGCCCCCGCTTCCGCTGGAGAATGGA
AATTGGCAAAGAGAGACGGAAAAGCTCCAATTTGCGCCTTTGCTATTTTAGGAGAGGTTGAAATTACGAGCCAAAGTGGAGTGATGCGCT
AAGCGGAGTGACCTCCGTACTCCAAGAAAAGAGAAAACCCAGGTTCTCTGCTTGTGAAGTGGCTCGAGCTCTTAGGCGTGAGGCATTATT
ATATAAATTCAAGCTCGCTCGTGATCCTTAGTACCCTGAGTTGCCTGAAGGGGGGAATGGCACTGCCTGCGTGTGCAGTCCGGGAGTTCG
AGCCGCCGCGGCAACCGGAGCGAGGAGCGCCCGTCCGCACCACCTGTCCCCGCCGGCATTCCAGAGTAGAGGCCGAATTGGCAGCGAGCC
GGCCCGGGTCGGTCGCCGCCTCAGTTCGCGCGGGCCCTCCTAGGGGTGTGTCTCACGGATTCCACACCCGGCCGCTCCTGGACAAGCCCC
GAAAGGCGTCTTCTTCCCTGGCGGGAGCCGCGTGCGCCCCGCTTTTCGCGCTGCTGTCCCGGGGCCGCCGCAGGCGGATGCACGTCCTCA
GGCGACGCTGGGACCTGGGCTCCCTCTGCCGGGCCCTGCTCACTCGGGGCCTGGCCGCCCTGGGCCACTCGCTGAAGCACGTGCTCGGTG
CGATCTTCTCCAAGATTTTCGGCCCCATGGCCAGCGTCGGGAACATGGATGAGAAATCCAACAAGCTGCTGCTAGCTTTGGTGATGCTCT
TCCTATTTGCCGTGATCGTCCTCCAATACGTGTGCCCCGGCACAGAATGCCAGCTCCTCCGCCTGCAGGCGTTCAGCTCCCCGGTGCCGG
ACCCGTACCGCTCGGAGGATGAGAGCTCCGCCAGGTTCGTGCCCCGCTACAATTTCACCCGCGGCGACCTCCTGCGCAAGGTAGACTTCG
ACATCAAGGGCGATGACCTGATCGTGTTCCTGCACATCCAGAAGACCGGGGGCACCACTTTCGGCCGCCACTTGGTGCGTAACATCCAGC
TGGAGCAGCCGTGCGAGTGCCGCGTGGGTCAGAAGAAATGCACTTGCCACCGGCCGGGTAAGCGGGAAACCTGGCTCTTCTCCAGGTTCT
CCACGGGCTGGAGCTGCGGGTTGCACGCCGACTGGACCGAGCTCACCAGCTGTGTGCCCTCCGTGGTGGACGGCAAGCGCGACGCCAGGC
TGAGACCGTCCAGGATGGCCATTTGGAAACACGATGTGCAAGATCAGTGGATTGGTCCAGGGAATATCTGTCGCAGCTTCAGTCTTTACG
TTAGTTGCAATTGCTGTAGATAGGTTCCAGTGTGTGGTCTACCCTTTTAAACCAAAGCTCACTATCAAGACAGCGTTTGTCATTATTATG
ATCATCTGGGTCCTAGCCATCACCATTATGTCTCCATCTGCAGTAATGTTACATGTGCAAGAAGAAAAATATTACCGAGTGAGACTCAAC
TCCCAGAATAAAACCAGTCCAGTCTACTGGTGCCGGGAAGACTGGCCAAATCAGGAAATGAGGAAGATCTACACCACTGTGCTGTTTGCC
AACATCTACCTGGCTCCCCTCTCCCTCATTGTCATCATGTATGGAAGGATTGGAATTTCACTCTTCAGGGCTGCAGTTCCTCACACAGGC
AGGAAGAACCAGGAGCAGTGGCACGTGGTGTCCAGGAAGAAGCAGAAGATCATTAAGATGCTCCTGATTGTGGCCCTGCTTTTTATTCTC
TCATGGCTGCCCCTGTGGACTCTAATGATGCTCTCAGACTACGCTGACCTTTCTCCAAATGAACTGCAGATCATCAACATCTACATCTAC
CCTTTTGCACACTGGCTGGCATTCGGCAACAGCAGTGTCAATCCCATCATTTATGGTTTCTTCAACGAGAATTTCCGCCGTGGTTTCCAA
GAAGCTTTCCAGCTCCAGCTCTGCCAAAAAAGAGCAAAGCCTATGGAAGCTTATGCCCTAAAAGCTAAAAGCCATGTGCTCATAAACACA
TCTAATCAGCTTGTCCAGGAATCTACATTTCAAAACCCTCATGGGGAAACCTTGCTTTATAGGAAAAGTGCTGAAAAACCCCAACAGGAA
TTAGTGATGGAAGAATTAAAAGAAACTACTAACAGCAGTGAGATTTAAAAAGAGCTAGTGTGATAATCCTAACTCTACTACGCATTATAT
ATTTAAATCCATTGCTTTTTGTGGCTTTGCACTTCAAATTTTTCAAAGAATGTTCTAAATAAAACATTTACTGAAAGCCCTCTCTGGCAA
AAAAATTAAAAATAAACAAAAATGGTCATAAGATCATAAACAATCTTATGTTGTATAAAAATACGTAGAGTGACTTAGACATGTTTGCAT
GAATAAATATATTTCTAGAGAACAGTT

>37618_37618_3_HS6ST2-NPFFR2_HS6ST2_chrX_132090836_ENST00000370836_NPFFR2_chr4_73003757_ENST00000358749_length(amino acids)=381AA_BP=346
MLVKWLELLGVRHYYINSSSLVILSTLSCLKGGMALPACAVREFEPPRQPERGAPVRTTCPRRHSRVEAELAASRPGSVAASVRAGPPRG
VSHGFHTRPLLDKPRKASSSLAGAACAPLFALLSRGRRRRMHVLRRRWDLGSLCRALLTRGLAALGHSLKHVLGAIFSKIFGPMASVGNM
DEKSNKLLLALVMLFLFAVIVLQYVCPGTECQLLRLQAFSSPVPDPYRSEDESSARFVPRYNFTRGDLLRKVDFDIKGDDLIVFLHIQKT
GGTTFGRHLVRNIQLEQPCECRVGQKKCTCHRPGKRETWLFSRFSTGWSCGLHADWTELTSCVPSVVDGKRDARLRPSRMAIWKHDVQDQ
WIGPGNICRSFSLYVSCNCCR

--------------------------------------------------------------
>37618_37618_4_HS6ST2-NPFFR2_HS6ST2_chrX_132090836_ENST00000370836_NPFFR2_chr4_73003757_ENST00000395999_length(transcript)=2547nt_BP=1363nt
AAGCCAGGCTGACCTTTATGCTCCCAGAATCATCAGCCTTTTCATTGGAAACCATGGAAGGACGGTTCTGGGAAAATAATGAAAATCATA
CCACACCATAGAGACAACCAGAAGCCCTGCTCAGATGACAGAGTTCTCCTCGCCTTCCAGAAAATGCCCCCGCTTCCGCTGGAGAATGGA
AATTGGCAAAGAGAGACGGAAAAGCTCCAATTTGCGCCTTTGCTATTTTAGGAGAGGTTGAAATTACGAGCCAAAGTGGAGTGATGCGCT
AAGCGGAGTGACCTCCGTACTCCAAGAAAAGAGAAAACCCAGGTTCTCTGCTTGTGAAGTGGCTCGAGCTCTTAGGCGTGAGGCATTATT
ATATAAATTCAAGCTCGCTCGTGATCCTTAGTACCCTGAGTTGCCTGAAGGGGGGAATGGCACTGCCTGCGTGTGCAGTCCGGGAGTTCG
AGCCGCCGCGGCAACCGGAGCGAGGAGCGCCCGTCCGCACCACCTGTCCCCGCCGGCATTCCAGAGTAGAGGCCGAATTGGCAGCGAGCC
GGCCCGGGTCGGTCGCCGCCTCAGTTCGCGCGGGCCCTCCTAGGGGTGTGTCTCACGGATTCCACACCCGGCCGCTCCTGGACAAGCCCC
GAAAGGCGTCTTCTTCCCTGGCGGGAGCCGCGTGCGCCCCGCTTTTCGCGCTGCTGTCCCGGGGCCGCCGCAGGCGGATGCACGTCCTCA
GGCGACGCTGGGACCTGGGCTCCCTCTGCCGGGCCCTGCTCACTCGGGGCCTGGCCGCCCTGGGCCACTCGCTGAAGCACGTGCTCGGTG
CGATCTTCTCCAAGATTTTCGGCCCCATGGCCAGCGTCGGGAACATGGATGAGAAATCCAACAAGCTGCTGCTAGCTTTGGTGATGCTCT
TCCTATTTGCCGTGATCGTCCTCCAATACGTGTGCCCCGGCACAGAATGCCAGCTCCTCCGCCTGCAGGCGTTCAGCTCCCCGGTGCCGG
ACCCGTACCGCTCGGAGGATGAGAGCTCCGCCAGGTTCGTGCCCCGCTACAATTTCACCCGCGGCGACCTCCTGCGCAAGGTAGACTTCG
ACATCAAGGGCGATGACCTGATCGTGTTCCTGCACATCCAGAAGACCGGGGGCACCACTTTCGGCCGCCACTTGGTGCGTAACATCCAGC
TGGAGCAGCCGTGCGAGTGCCGCGTGGGTCAGAAGAAATGCACTTGCCACCGGCCGGGTAAGCGGGAAACCTGGCTCTTCTCCAGGTTCT
CCACGGGCTGGAGCTGCGGGTTGCACGCCGACTGGACCGAGCTCACCAGCTGTGTGCCCTCCGTGGTGGACGGCAAGCGCGACGCCAGGC
TGAGACCGTCCAGGATGGCCATTTGGAAACACGATGTGCAAGATCAGTGGATTGGTCCAGGGAATATCTGTCGCAGCTTCAGTCTTTACG
TTAGTTGCAATTGCTGTAGATAGGTTCCAGTGTGTGGTCTACCCTTTTAAACCAAAGCTCACTATCAAGACAGCGTTTGTCATTATTATG
ATCATCTGGGTCCTAGCCATCACCATTATGTCTCCATCTGCAGTAATGTTACATGTGCAAGAAGAAAAATATTACCGAGTGAGACTCAAC
TCCCAGAATAAAACCAGTCCAGTCTACTGGTGCCGGGAAGACTGGCCAAATCAGGAAATGAGGAAGATCTACACCACTGTGCTGTTTGCC
AACATCTACCTGGCTCCCCTCTCCCTCATTGTCATCATGTATGGAAGGATTGGAATTTCACTCTTCAGGGCTGCAGTTCCTCACACAGGC
AGGAAGAACCAGGAGCAGTGGCACGTGGTGTCCAGGAAGAAGCAGAAGATCATTAAGATGCTCCTGATTGTGGCCCTGCTTTTTATTCTC
TCATGGCTGCCCCTGTGGACTCTAATGATGCTCTCAGACTACGCTGACCTTTCTCCAAATGAACTGCAGATCATCAACATCTACATCTAC
CCTTTTGCACACTGGCTGGCATTCGGCAACAGCAGTGTCAATCCCATCATTTATGGTTTCTTCAACGAGAATTTCCGCCGTGGTTTCCAA
GAAGCTTTCCAGCTCCAGCTCTGCCAAAAAAGAGCAAAGCCTATGGAAGCTTATGCCCTAAAAGCTAAAAGCCATGTGCTCATAAACACA
TCTAATCAGCTTGTCCAGGAATCTACATTTCAAAACCCTCATGGGGAAACCTTGCTTTATAGGAAAAGTGCTGAAAAACCCCAACAGGAA
TTAGTGATGGAAGAATTAAAAGAAACTACTAACAGCAGTGAGATTTAAAAAGAGCTAGTGTGATAATCCTAACTCTACTACGCATTATAT
ATTTAAATCCATTGCTTTTTGTGGCTTTGCACTTCAAATTTTTCAAAGAATGTTCTAAATAAAACATTTACTGAAAGCCCTCTCTGGCAA
AAAAATTAAAAATAAACAAAAATGGTCATAAGATCATAAACAATCTTATGTTGTATAAAAATACGTAGAGTGACTTAGACATGTTTGCAT
GAATAAATATATTTCTAGAGAACAGTT

>37618_37618_4_HS6ST2-NPFFR2_HS6ST2_chrX_132090836_ENST00000370836_NPFFR2_chr4_73003757_ENST00000395999_length(amino acids)=381AA_BP=346
MLVKWLELLGVRHYYINSSSLVILSTLSCLKGGMALPACAVREFEPPRQPERGAPVRTTCPRRHSRVEAELAASRPGSVAASVRAGPPRG
VSHGFHTRPLLDKPRKASSSLAGAACAPLFALLSRGRRRRMHVLRRRWDLGSLCRALLTRGLAALGHSLKHVLGAIFSKIFGPMASVGNM
DEKSNKLLLALVMLFLFAVIVLQYVCPGTECQLLRLQAFSSPVPDPYRSEDESSARFVPRYNFTRGDLLRKVDFDIKGDDLIVFLHIQKT
GGTTFGRHLVRNIQLEQPCECRVGQKKCTCHRPGKRETWLFSRFSTGWSCGLHADWTELTSCVPSVVDGKRDARLRPSRMAIWKHDVQDQ
WIGPGNICRSFSLYVSCNCCR

--------------------------------------------------------------
>37618_37618_5_HS6ST2-NPFFR2_HS6ST2_chrX_132090836_ENST00000521489_NPFFR2_chr4_73003757_ENST00000308744_length(transcript)=2553nt_BP=1363nt
AAGCCAGGCTGACCTTTATGCTCCCAGAATCATCAGCCTTTTCATTGGAAACCATGGAAGGACGGTTCTGGGAAAATAATGAAAATCATA
CCACACCATAGAGACAACCAGAAGCCCTGCTCAGATGACAGAGTTCTCCTCGCCTTCCAGAAAATGCCCCCGCTTCCGCTGGAGAATGGA
AATTGGCAAAGAGAGACGGAAAAGCTCCAATTTGCGCCTTTGCTATTTTAGGAGAGGTTGAAATTACGAGCCAAAGTGGAGTGATGCGCT
AAGCGGAGTGACCTCCGTACTCCAAGAAAAGAGAAAACCCAGGTTCTCTGCTTGTGAAGTGGCTCGAGCTCTTAGGCGTGAGGCATTATT
ATATAAATTCAAGCTCGCTCGTGATCCTTAGTACCCTGAGTTGCCTGAAGGGGGGAATGGCACTGCCTGCGTGTGCAGTCCGGGAGTTCG
AGCCGCCGCGGCAACCGGAGCGAGGAGCGCCCGTCCGCACCACCTGTCCCCGCCGGCATTCCAGAGTAGAGGCCGAATTGGCAGCGAGCC
GGCCCGGGTCGGTCGCCGCCTCAGTTCGCGCGGGCCCTCCTAGGGGTGTGTCTCACGGATTCCACACCCGGCCGCTCCTGGACAAGCCCC
GAAAGGCGTCTTCTTCCCTGGCGGGAGCCGCGTGCGCCCCGCTTTTCGCGCTGCTGTCCCGGGGCCGCCGCAGGCGGATGCACGTCCTCA
GGCGACGCTGGGACCTGGGCTCCCTCTGCCGGGCCCTGCTCACTCGGGGCCTGGCCGCCCTGGGCCACTCGCTGAAGCACGTGCTCGGTG
CGATCTTCTCCAAGATTTTCGGCCCCATGGCCAGCGTCGGGAACATGGATGAGAAATCCAACAAGCTGCTGCTAGCTTTGGTGATGCTCT
TCCTATTTGCCGTGATCGTCCTCCAATACGTGTGCCCCGGCACAGAATGCCAGCTCCTCCGCCTGCAGGCGTTCAGCTCCCCGGTGCCGG
ACCCGTACCGCTCGGAGGATGAGAGCTCCGCCAGGTTCGTGCCCCGCTACAATTTCACCCGCGGCGACCTCCTGCGCAAGGTAGACTTCG
ACATCAAGGGCGATGACCTGATCGTGTTCCTGCACATCCAGAAGACCGGGGGCACCACTTTCGGCCGCCACTTGGTGCGTAACATCCAGC
TGGAGCAGCCGTGCGAGTGCCGCGTGGGTCAGAAGAAATGCACTTGCCACCGGCCGGGTAAGCGGGAAACCTGGCTCTTCTCCAGGTTCT
CCACGGGCTGGAGCTGCGGGTTGCACGCCGACTGGACCGAGCTCACCAGCTGTGTGCCCTCCGTGGTGGACGGCAAGCGCGACGCCAGGC
TGAGACCGTCCAGGATGGCCATTTGGAAACACGATGTGCAAGATCAGTGGATTGGTCCAGGGAATATCTGTCGCAGCTTCAGTCTTTACG
TTAGTTGCAATTGCTGTAGATAGGTTCCAGTGTGTGGTCTACCCTTTTAAACCAAAGCTCACTATCAAGACAGCGTTTGTCATTATTATG
ATCATCTGGGTCCTAGCCATCACCATTATGTCTCCATCTGCAGTAATGTTACATGTGCAAGAAGAAAAATATTACCGAGTGAGACTCAAC
TCCCAGAATAAAACCAGTCCAGTCTACTGGTGCCGGGAAGACTGGCCAAATCAGGAAATGAGGAAGATCTACACCACTGTGCTGTTTGCC
AACATCTACCTGGCTCCCCTCTCCCTCATTGTCATCATGTATGGAAGGATTGGAATTTCACTCTTCAGGGCTGCAGTTCCTCACACAGGC
AGGAAGAACCAGGAGCAGTGGCACGTGGTGTCCAGGAAGAAGCAGAAGATCATTAAGATGCTCCTGATTGTGGCCCTGCTTTTTATTCTC
TCATGGCTGCCCCTGTGGACTCTAATGATGCTCTCAGACTACGCTGACCTTTCTCCAAATGAACTGCAGATCATCAACATCTACATCTAC
CCTTTTGCACACTGGCTGGCATTCGGCAACAGCAGTGTCAATCCCATCATTTATGGTTTCTTCAACGAGAATTTCCGCCGTGGTTTCCAA
GAAGCTTTCCAGCTCCAGCTCTGCCAAAAAAGAGCAAAGCCTATGGAAGCTTATGCCCTAAAAGCTAAAAGCCATGTGCTCATAAACACA
TCTAATCAGCTTGTCCAGGAATCTACATTTCAAAACCCTCATGGGGAAACCTTGCTTTATAGGAAAAGTGCTGAAAAACCCCAACAGGAA
TTAGTGATGGAAGAATTAAAAGAAACTACTAACAGCAGTGAGATTTAAAAAGAGCTAGTGTGATAATCCTAACTCTACTACGCATTATAT
ATTTAAATCCATTGCTTTTTGTGGCTTTGCACTTCAAATTTTTCAAAGAATGTTCTAAATAAAACATTTACTGAAAGCCCTCTCTGGCAA
AAAAATTAAAAATAAACAAAAATGGTCATAAGATCATAAACAATCTTATGTTGTATAAAAATACGTAGAGTGACTTAGACATGTTTGCAT
GAATAAATATATTTCTAGAGAACAGTTTACAAA

>37618_37618_5_HS6ST2-NPFFR2_HS6ST2_chrX_132090836_ENST00000521489_NPFFR2_chr4_73003757_ENST00000308744_length(amino acids)=381AA_BP=346
MLVKWLELLGVRHYYINSSSLVILSTLSCLKGGMALPACAVREFEPPRQPERGAPVRTTCPRRHSRVEAELAASRPGSVAASVRAGPPRG
VSHGFHTRPLLDKPRKASSSLAGAACAPLFALLSRGRRRRMHVLRRRWDLGSLCRALLTRGLAALGHSLKHVLGAIFSKIFGPMASVGNM
DEKSNKLLLALVMLFLFAVIVLQYVCPGTECQLLRLQAFSSPVPDPYRSEDESSARFVPRYNFTRGDLLRKVDFDIKGDDLIVFLHIQKT
GGTTFGRHLVRNIQLEQPCECRVGQKKCTCHRPGKRETWLFSRFSTGWSCGLHADWTELTSCVPSVVDGKRDARLRPSRMAIWKHDVQDQ
WIGPGNICRSFSLYVSCNCCR

--------------------------------------------------------------
>37618_37618_6_HS6ST2-NPFFR2_HS6ST2_chrX_132090836_ENST00000521489_NPFFR2_chr4_73003757_ENST00000358749_length(transcript)=2547nt_BP=1363nt
AAGCCAGGCTGACCTTTATGCTCCCAGAATCATCAGCCTTTTCATTGGAAACCATGGAAGGACGGTTCTGGGAAAATAATGAAAATCATA
CCACACCATAGAGACAACCAGAAGCCCTGCTCAGATGACAGAGTTCTCCTCGCCTTCCAGAAAATGCCCCCGCTTCCGCTGGAGAATGGA
AATTGGCAAAGAGAGACGGAAAAGCTCCAATTTGCGCCTTTGCTATTTTAGGAGAGGTTGAAATTACGAGCCAAAGTGGAGTGATGCGCT
AAGCGGAGTGACCTCCGTACTCCAAGAAAAGAGAAAACCCAGGTTCTCTGCTTGTGAAGTGGCTCGAGCTCTTAGGCGTGAGGCATTATT
ATATAAATTCAAGCTCGCTCGTGATCCTTAGTACCCTGAGTTGCCTGAAGGGGGGAATGGCACTGCCTGCGTGTGCAGTCCGGGAGTTCG
AGCCGCCGCGGCAACCGGAGCGAGGAGCGCCCGTCCGCACCACCTGTCCCCGCCGGCATTCCAGAGTAGAGGCCGAATTGGCAGCGAGCC
GGCCCGGGTCGGTCGCCGCCTCAGTTCGCGCGGGCCCTCCTAGGGGTGTGTCTCACGGATTCCACACCCGGCCGCTCCTGGACAAGCCCC
GAAAGGCGTCTTCTTCCCTGGCGGGAGCCGCGTGCGCCCCGCTTTTCGCGCTGCTGTCCCGGGGCCGCCGCAGGCGGATGCACGTCCTCA
GGCGACGCTGGGACCTGGGCTCCCTCTGCCGGGCCCTGCTCACTCGGGGCCTGGCCGCCCTGGGCCACTCGCTGAAGCACGTGCTCGGTG
CGATCTTCTCCAAGATTTTCGGCCCCATGGCCAGCGTCGGGAACATGGATGAGAAATCCAACAAGCTGCTGCTAGCTTTGGTGATGCTCT
TCCTATTTGCCGTGATCGTCCTCCAATACGTGTGCCCCGGCACAGAATGCCAGCTCCTCCGCCTGCAGGCGTTCAGCTCCCCGGTGCCGG
ACCCGTACCGCTCGGAGGATGAGAGCTCCGCCAGGTTCGTGCCCCGCTACAATTTCACCCGCGGCGACCTCCTGCGCAAGGTAGACTTCG
ACATCAAGGGCGATGACCTGATCGTGTTCCTGCACATCCAGAAGACCGGGGGCACCACTTTCGGCCGCCACTTGGTGCGTAACATCCAGC
TGGAGCAGCCGTGCGAGTGCCGCGTGGGTCAGAAGAAATGCACTTGCCACCGGCCGGGTAAGCGGGAAACCTGGCTCTTCTCCAGGTTCT
CCACGGGCTGGAGCTGCGGGTTGCACGCCGACTGGACCGAGCTCACCAGCTGTGTGCCCTCCGTGGTGGACGGCAAGCGCGACGCCAGGC
TGAGACCGTCCAGGATGGCCATTTGGAAACACGATGTGCAAGATCAGTGGATTGGTCCAGGGAATATCTGTCGCAGCTTCAGTCTTTACG
TTAGTTGCAATTGCTGTAGATAGGTTCCAGTGTGTGGTCTACCCTTTTAAACCAAAGCTCACTATCAAGACAGCGTTTGTCATTATTATG
ATCATCTGGGTCCTAGCCATCACCATTATGTCTCCATCTGCAGTAATGTTACATGTGCAAGAAGAAAAATATTACCGAGTGAGACTCAAC
TCCCAGAATAAAACCAGTCCAGTCTACTGGTGCCGGGAAGACTGGCCAAATCAGGAAATGAGGAAGATCTACACCACTGTGCTGTTTGCC
AACATCTACCTGGCTCCCCTCTCCCTCATTGTCATCATGTATGGAAGGATTGGAATTTCACTCTTCAGGGCTGCAGTTCCTCACACAGGC
AGGAAGAACCAGGAGCAGTGGCACGTGGTGTCCAGGAAGAAGCAGAAGATCATTAAGATGCTCCTGATTGTGGCCCTGCTTTTTATTCTC
TCATGGCTGCCCCTGTGGACTCTAATGATGCTCTCAGACTACGCTGACCTTTCTCCAAATGAACTGCAGATCATCAACATCTACATCTAC
CCTTTTGCACACTGGCTGGCATTCGGCAACAGCAGTGTCAATCCCATCATTTATGGTTTCTTCAACGAGAATTTCCGCCGTGGTTTCCAA
GAAGCTTTCCAGCTCCAGCTCTGCCAAAAAAGAGCAAAGCCTATGGAAGCTTATGCCCTAAAAGCTAAAAGCCATGTGCTCATAAACACA
TCTAATCAGCTTGTCCAGGAATCTACATTTCAAAACCCTCATGGGGAAACCTTGCTTTATAGGAAAAGTGCTGAAAAACCCCAACAGGAA
TTAGTGATGGAAGAATTAAAAGAAACTACTAACAGCAGTGAGATTTAAAAAGAGCTAGTGTGATAATCCTAACTCTACTACGCATTATAT
ATTTAAATCCATTGCTTTTTGTGGCTTTGCACTTCAAATTTTTCAAAGAATGTTCTAAATAAAACATTTACTGAAAGCCCTCTCTGGCAA
AAAAATTAAAAATAAACAAAAATGGTCATAAGATCATAAACAATCTTATGTTGTATAAAAATACGTAGAGTGACTTAGACATGTTTGCAT
GAATAAATATATTTCTAGAGAACAGTT

>37618_37618_6_HS6ST2-NPFFR2_HS6ST2_chrX_132090836_ENST00000521489_NPFFR2_chr4_73003757_ENST00000358749_length(amino acids)=381AA_BP=346
MLVKWLELLGVRHYYINSSSLVILSTLSCLKGGMALPACAVREFEPPRQPERGAPVRTTCPRRHSRVEAELAASRPGSVAASVRAGPPRG
VSHGFHTRPLLDKPRKASSSLAGAACAPLFALLSRGRRRRMHVLRRRWDLGSLCRALLTRGLAALGHSLKHVLGAIFSKIFGPMASVGNM
DEKSNKLLLALVMLFLFAVIVLQYVCPGTECQLLRLQAFSSPVPDPYRSEDESSARFVPRYNFTRGDLLRKVDFDIKGDDLIVFLHIQKT
GGTTFGRHLVRNIQLEQPCECRVGQKKCTCHRPGKRETWLFSRFSTGWSCGLHADWTELTSCVPSVVDGKRDARLRPSRMAIWKHDVQDQ
WIGPGNICRSFSLYVSCNCCR

--------------------------------------------------------------
>37618_37618_7_HS6ST2-NPFFR2_HS6ST2_chrX_132090836_ENST00000521489_NPFFR2_chr4_73003757_ENST00000395999_length(transcript)=2547nt_BP=1363nt
AAGCCAGGCTGACCTTTATGCTCCCAGAATCATCAGCCTTTTCATTGGAAACCATGGAAGGACGGTTCTGGGAAAATAATGAAAATCATA
CCACACCATAGAGACAACCAGAAGCCCTGCTCAGATGACAGAGTTCTCCTCGCCTTCCAGAAAATGCCCCCGCTTCCGCTGGAGAATGGA
AATTGGCAAAGAGAGACGGAAAAGCTCCAATTTGCGCCTTTGCTATTTTAGGAGAGGTTGAAATTACGAGCCAAAGTGGAGTGATGCGCT
AAGCGGAGTGACCTCCGTACTCCAAGAAAAGAGAAAACCCAGGTTCTCTGCTTGTGAAGTGGCTCGAGCTCTTAGGCGTGAGGCATTATT
ATATAAATTCAAGCTCGCTCGTGATCCTTAGTACCCTGAGTTGCCTGAAGGGGGGAATGGCACTGCCTGCGTGTGCAGTCCGGGAGTTCG
AGCCGCCGCGGCAACCGGAGCGAGGAGCGCCCGTCCGCACCACCTGTCCCCGCCGGCATTCCAGAGTAGAGGCCGAATTGGCAGCGAGCC
GGCCCGGGTCGGTCGCCGCCTCAGTTCGCGCGGGCCCTCCTAGGGGTGTGTCTCACGGATTCCACACCCGGCCGCTCCTGGACAAGCCCC
GAAAGGCGTCTTCTTCCCTGGCGGGAGCCGCGTGCGCCCCGCTTTTCGCGCTGCTGTCCCGGGGCCGCCGCAGGCGGATGCACGTCCTCA
GGCGACGCTGGGACCTGGGCTCCCTCTGCCGGGCCCTGCTCACTCGGGGCCTGGCCGCCCTGGGCCACTCGCTGAAGCACGTGCTCGGTG
CGATCTTCTCCAAGATTTTCGGCCCCATGGCCAGCGTCGGGAACATGGATGAGAAATCCAACAAGCTGCTGCTAGCTTTGGTGATGCTCT
TCCTATTTGCCGTGATCGTCCTCCAATACGTGTGCCCCGGCACAGAATGCCAGCTCCTCCGCCTGCAGGCGTTCAGCTCCCCGGTGCCGG
ACCCGTACCGCTCGGAGGATGAGAGCTCCGCCAGGTTCGTGCCCCGCTACAATTTCACCCGCGGCGACCTCCTGCGCAAGGTAGACTTCG
ACATCAAGGGCGATGACCTGATCGTGTTCCTGCACATCCAGAAGACCGGGGGCACCACTTTCGGCCGCCACTTGGTGCGTAACATCCAGC
TGGAGCAGCCGTGCGAGTGCCGCGTGGGTCAGAAGAAATGCACTTGCCACCGGCCGGGTAAGCGGGAAACCTGGCTCTTCTCCAGGTTCT
CCACGGGCTGGAGCTGCGGGTTGCACGCCGACTGGACCGAGCTCACCAGCTGTGTGCCCTCCGTGGTGGACGGCAAGCGCGACGCCAGGC
TGAGACCGTCCAGGATGGCCATTTGGAAACACGATGTGCAAGATCAGTGGATTGGTCCAGGGAATATCTGTCGCAGCTTCAGTCTTTACG
TTAGTTGCAATTGCTGTAGATAGGTTCCAGTGTGTGGTCTACCCTTTTAAACCAAAGCTCACTATCAAGACAGCGTTTGTCATTATTATG
ATCATCTGGGTCCTAGCCATCACCATTATGTCTCCATCTGCAGTAATGTTACATGTGCAAGAAGAAAAATATTACCGAGTGAGACTCAAC
TCCCAGAATAAAACCAGTCCAGTCTACTGGTGCCGGGAAGACTGGCCAAATCAGGAAATGAGGAAGATCTACACCACTGTGCTGTTTGCC
AACATCTACCTGGCTCCCCTCTCCCTCATTGTCATCATGTATGGAAGGATTGGAATTTCACTCTTCAGGGCTGCAGTTCCTCACACAGGC
AGGAAGAACCAGGAGCAGTGGCACGTGGTGTCCAGGAAGAAGCAGAAGATCATTAAGATGCTCCTGATTGTGGCCCTGCTTTTTATTCTC
TCATGGCTGCCCCTGTGGACTCTAATGATGCTCTCAGACTACGCTGACCTTTCTCCAAATGAACTGCAGATCATCAACATCTACATCTAC
CCTTTTGCACACTGGCTGGCATTCGGCAACAGCAGTGTCAATCCCATCATTTATGGTTTCTTCAACGAGAATTTCCGCCGTGGTTTCCAA
GAAGCTTTCCAGCTCCAGCTCTGCCAAAAAAGAGCAAAGCCTATGGAAGCTTATGCCCTAAAAGCTAAAAGCCATGTGCTCATAAACACA
TCTAATCAGCTTGTCCAGGAATCTACATTTCAAAACCCTCATGGGGAAACCTTGCTTTATAGGAAAAGTGCTGAAAAACCCCAACAGGAA
TTAGTGATGGAAGAATTAAAAGAAACTACTAACAGCAGTGAGATTTAAAAAGAGCTAGTGTGATAATCCTAACTCTACTACGCATTATAT
ATTTAAATCCATTGCTTTTTGTGGCTTTGCACTTCAAATTTTTCAAAGAATGTTCTAAATAAAACATTTACTGAAAGCCCTCTCTGGCAA
AAAAATTAAAAATAAACAAAAATGGTCATAAGATCATAAACAATCTTATGTTGTATAAAAATACGTAGAGTGACTTAGACATGTTTGCAT
GAATAAATATATTTCTAGAGAACAGTT

>37618_37618_7_HS6ST2-NPFFR2_HS6ST2_chrX_132090836_ENST00000521489_NPFFR2_chr4_73003757_ENST00000395999_length(amino acids)=381AA_BP=346
MLVKWLELLGVRHYYINSSSLVILSTLSCLKGGMALPACAVREFEPPRQPERGAPVRTTCPRRHSRVEAELAASRPGSVAASVRAGPPRG
VSHGFHTRPLLDKPRKASSSLAGAACAPLFALLSRGRRRRMHVLRRRWDLGSLCRALLTRGLAALGHSLKHVLGAIFSKIFGPMASVGNM
DEKSNKLLLALVMLFLFAVIVLQYVCPGTECQLLRLQAFSSPVPDPYRSEDESSARFVPRYNFTRGDLLRKVDFDIKGDDLIVFLHIQKT
GGTTFGRHLVRNIQLEQPCECRVGQKKCTCHRPGKRETWLFSRFSTGWSCGLHADWTELTSCVPSVVDGKRDARLRPSRMAIWKHDVQDQ
WIGPGNICRSFSLYVSCNCCR

--------------------------------------------------------------

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Fusion Gene PPI Analysis for HS6ST2-NPFFR2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for HS6ST2-NPFFR2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for HS6ST2-NPFFR2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource