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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:SLC25A14-BCORL1 (FusionGDB2 ID:HG9016TG63035)

Fusion Gene Summary for SLC25A14-BCORL1

check button Fusion gene summary
Fusion gene informationFusion gene name: SLC25A14-BCORL1
Fusion gene ID: hg9016tg63035
HgeneTgene
Gene symbol

SLC25A14

BCORL1

Gene ID

9016

63035

Gene namesolute carrier family 25 member 14BCL6 corepressor like 1
SynonymsBMCP1|UCP5BCoR-L1|CXorf10|SHUVER
Cytomap('SLC25A14')('BCORL1')

Xq26.1

Xq26.1

Type of geneprotein-codingprotein-coding
Descriptionbrain mitochondrial carrier protein 1mitochondrial uncoupling protein 5BCL-6 corepressor-like protein 1BCoR-like protein 1
Modification date2020031320200313
UniProtAcc.

Q5H9F3

Ensembl transtripts involved in fusion geneENST00000467496, ENST00000218197, 
ENST00000339231, ENST00000361980, 
ENST00000543953, ENST00000545805, 
Fusion gene scores* DoF score1 X 1 X 1=16 X 6 X 3=108
# samples 16
** MAII scorelog2(1/1*10)=3.32192809488736log2(6/108*10)=-0.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: SLC25A14 [Title/Abstract] AND BCORL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointSLC25A14(129484705)-BCORL1(129184692), # samples:3
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID


check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-PG-A915-01ASLC25A14chrX

129484705

-BCORL1chrX

129184692

+
ChimerDB4UCECTCGA-PG-A915-01ASLC25A14chrX

129484705

+BCORL1chrX

129184692

+


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Fusion Gene ORF analysis for SLC25A14-BCORL1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-intronENST00000467496ENST00000218147SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
3UTR-intronENST00000467496ENST00000303743SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
3UTR-intronENST00000467496ENST00000359304SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
3UTR-intronENST00000467496ENST00000540052SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
3UTR-intronENST00000467496ENST00000607874SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000218197ENST00000218147SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000218197ENST00000303743SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000218197ENST00000359304SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000218197ENST00000540052SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000218197ENST00000607874SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000339231ENST00000218147SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000339231ENST00000303743SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000339231ENST00000359304SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000339231ENST00000540052SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000339231ENST00000607874SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000361980ENST00000218147SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000361980ENST00000303743SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000361980ENST00000359304SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000361980ENST00000540052SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000361980ENST00000607874SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000543953ENST00000218147SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000543953ENST00000303743SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000543953ENST00000359304SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000543953ENST00000540052SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000543953ENST00000607874SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000545805ENST00000218147SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000545805ENST00000303743SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000545805ENST00000359304SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000545805ENST00000540052SLC25A14chrX

129484705

+BCORL1chrX

129184692

+
5CDS-intronENST00000545805ENST00000607874SLC25A14chrX

129484705

+BCORL1chrX

129184692

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for SLC25A14-BCORL1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
SLC25A14chrX129484705+BCORL1chrX129184691+8.13E-060.9999919
SLC25A14chrX129484705+BCORL1chrX129184691+8.13E-060.9999919


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for SLC25A14-BCORL1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:129484705/:129184692)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.BCORL1

Q5H9F3

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. {ECO:0000269|PubMed:17379597}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for SLC25A14-BCORL1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for SLC25A14-BCORL1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for SLC25A14-BCORL1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for SLC25A14-BCORL1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneC0027708Nephroblastoma1CTD_human
TgeneC0233514Abnormal behavior1GENOMICS_ENGLAND
TgeneC2930471Bilateral Wilms Tumor1CTD_human