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![]() | Fusion Gene Summary |
![]() | Fusion Gene ORF analysis |
![]() | Fusion Genomic Features |
![]() | Fusion Protein Features |
![]() | Fusion Gene Sequence |
![]() | Fusion Gene PPI analysis |
![]() | Related Drugs |
![]() | Related Diseases |
Fusion gene:SLC7A7-ACIN1 (FusionGDB2 ID:HG9056TG22985) |
Fusion Gene Summary for SLC7A7-ACIN1 |
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Fusion gene information | Fusion gene name: SLC7A7-ACIN1 | Fusion gene ID: hg9056tg22985 | Hgene | Tgene | Gene symbol | SLC7A7 | ACIN1 | Gene ID | 9056 | 22985 |
Gene name | solute carrier family 7 member 7 | apoptotic chromatin condensation inducer 1 | |
Synonyms | LAT3|LPI|MOP-2|Y+LAT1|y+LAT-1 | ACINUS|ACN|fSAP152 | |
Cytomap | ('SLC7A7')('ACIN1') 14q11.2 | 14q11.2 | |
Type of gene | protein-coding | protein-coding | |
Description | Y+L amino acid transporter 1monocyte amino acid permease 2solute carrier family 7 (amino acid transporter light chain, y+L system), member 7solute carrier family 7 (cationic amino acid transporter, y+ system), member 7y(+)L-type amino acid transporter | apoptotic chromatin condensation inducer in the nucleusfunctional spliceosome-associated protein 152 | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | . | Q9UKV3 | |
Ensembl transtripts involved in fusion gene | ENST00000285850, ENST00000397528, ENST00000397529, ENST00000397532, ENST00000555702, ENST00000554061, ENST00000554517, | ||
Fusion gene scores | * DoF score | 4 X 5 X 3=60 | 11 X 11 X 4=484 |
# samples | 5 | 12 | |
** MAII score | log2(5/60*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(12/484*10)=-2.01197264166608 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context | PubMed: SLC7A7 [Title/Abstract] AND ACIN1 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint | SLC7A7(23282109)-ACIN1(23533697), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | SLC7A7-ACIN1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. SLC7A7-ACIN1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. SLC7A7-ACIN1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Tgene | ACIN1 | GO:0030263 | apoptotic chromosome condensation | 10490026 |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | ESCA | TCGA-R6-A8W5-01B | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
ChimerDB4 | ESCA | TCGA-R6-A8W5 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
ChimerDB4 | ESCA | TCGA-R6-A8W5 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
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Fusion Gene ORF analysis for SLC7A7-ACIN1 |
![]() * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
5CDS-intron | ENST00000285850 | ENST00000555352 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
5CDS-intron | ENST00000285850 | ENST00000555352 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
5CDS-intron | ENST00000397528 | ENST00000555352 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
5CDS-intron | ENST00000397528 | ENST00000555352 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
5CDS-intron | ENST00000397529 | ENST00000555352 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
5CDS-intron | ENST00000397529 | ENST00000555352 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
5CDS-intron | ENST00000397532 | ENST00000555352 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
5CDS-intron | ENST00000397532 | ENST00000555352 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
5CDS-intron | ENST00000555702 | ENST00000555352 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
5CDS-intron | ENST00000555702 | ENST00000555352 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000285850 | ENST00000262710 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000285850 | ENST00000262710 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000285850 | ENST00000338631 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000285850 | ENST00000338631 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000285850 | ENST00000357481 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000285850 | ENST00000357481 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000285850 | ENST00000397341 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000285850 | ENST00000397341 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000285850 | ENST00000457657 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000285850 | ENST00000457657 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000285850 | ENST00000555053 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000285850 | ENST00000555053 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000285850 | ENST00000557515 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000285850 | ENST00000557515 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000285850 | ENST00000605057 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000285850 | ENST00000605057 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397528 | ENST00000262710 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397528 | ENST00000262710 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397528 | ENST00000338631 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397528 | ENST00000338631 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397528 | ENST00000357481 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397528 | ENST00000357481 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397528 | ENST00000397341 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397528 | ENST00000397341 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397528 | ENST00000457657 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397528 | ENST00000457657 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397528 | ENST00000555053 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397528 | ENST00000555053 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397528 | ENST00000557515 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397528 | ENST00000557515 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397528 | ENST00000605057 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397528 | ENST00000605057 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397529 | ENST00000262710 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397529 | ENST00000262710 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397529 | ENST00000338631 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397529 | ENST00000338631 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397529 | ENST00000357481 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397529 | ENST00000357481 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397529 | ENST00000397341 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397529 | ENST00000397341 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397529 | ENST00000457657 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397529 | ENST00000457657 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397529 | ENST00000555053 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397529 | ENST00000555053 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397529 | ENST00000557515 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397529 | ENST00000557515 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397529 | ENST00000605057 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397529 | ENST00000605057 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397532 | ENST00000262710 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397532 | ENST00000262710 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397532 | ENST00000338631 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397532 | ENST00000338631 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397532 | ENST00000357481 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397532 | ENST00000357481 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397532 | ENST00000397341 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397532 | ENST00000397341 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397532 | ENST00000457657 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397532 | ENST00000457657 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397532 | ENST00000555053 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397532 | ENST00000555053 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397532 | ENST00000557515 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397532 | ENST00000557515 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397532 | ENST00000605057 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000397532 | ENST00000605057 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000555702 | ENST00000262710 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000555702 | ENST00000262710 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000555702 | ENST00000338631 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000555702 | ENST00000338631 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000555702 | ENST00000357481 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000555702 | ENST00000357481 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000555702 | ENST00000397341 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000555702 | ENST00000397341 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000555702 | ENST00000457657 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000555702 | ENST00000457657 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000555702 | ENST00000555053 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000555702 | ENST00000555053 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000555702 | ENST00000557515 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000555702 | ENST00000557515 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000555702 | ENST00000605057 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
Frame-shift | ENST00000555702 | ENST00000605057 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554061 | ENST00000262710 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554061 | ENST00000262710 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554061 | ENST00000338631 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554061 | ENST00000338631 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554061 | ENST00000357481 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554061 | ENST00000357481 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554061 | ENST00000397341 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554061 | ENST00000397341 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554061 | ENST00000457657 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554061 | ENST00000457657 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554061 | ENST00000555053 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554061 | ENST00000555053 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554061 | ENST00000557515 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554061 | ENST00000557515 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554061 | ENST00000605057 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554061 | ENST00000605057 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554517 | ENST00000262710 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554517 | ENST00000262710 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554517 | ENST00000338631 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554517 | ENST00000338631 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554517 | ENST00000357481 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554517 | ENST00000357481 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554517 | ENST00000397341 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554517 | ENST00000397341 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554517 | ENST00000457657 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554517 | ENST00000457657 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554517 | ENST00000555053 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554517 | ENST00000555053 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554517 | ENST00000557515 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554517 | ENST00000557515 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554517 | ENST00000605057 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
intron-3CDS | ENST00000554517 | ENST00000605057 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
intron-intron | ENST00000554061 | ENST00000555352 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
intron-intron | ENST00000554061 | ENST00000555352 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
intron-intron | ENST00000554517 | ENST00000555352 | SLC7A7 | chr14 | 23282109 | - | ACIN1 | chr14 | 23533697 | - |
intron-intron | ENST00000554517 | ENST00000555352 | SLC7A7 | chr14 | 23282108 | - | ACIN1 | chr14 | 23533697 | - |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
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Fusion Genomic Features for SLC7A7-ACIN1 |
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Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
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Fusion Protein Features for SLC7A7-ACIN1 |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:23282109/:23533697) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
. | ACIN1 |
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Auxiliary component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junction on mRNAs. The EJC is a dynamic structure consisting of core proteins and several peripheral nuclear and cytoplasmic associated factors that join the complex only transiently either during EJC assembly or during subsequent mRNA metabolism. Component of the ASAP complexes which bind RNA in a sequence-independent manner and are proposed to be recruited to the EJC prior to or during the splicing process and to regulate specific excision of introns in specific transcription subsets; ACIN1 confers RNA-binding to the complex. The ASAP complex can inhibit RNA processing during in vitro splicing reactions. The ASAP complex promotes apoptosis and is disassembled after induction of apoptosis. Involved in the splicing modulation of BCL2L1/Bcl-X (and probably other apoptotic genes); specifically inhibits formation of proapoptotic isoforms such as Bcl-X(S); the activity is different from the established EJC assembly and function. Induces apoptotic chromatin condensation after activation by CASP3. Regulates cyclin A1, but not cyclin A2, expression in leukemia cells. {ECO:0000269|PubMed:10490026, ECO:0000269|PubMed:12665594, ECO:0000269|PubMed:18559500, ECO:0000269|PubMed:22203037, ECO:0000269|PubMed:22388736}. |
![]() * Minus value of BPloci means that the break pointn is located before the CDS. |
- In-frame and retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
- In-frame and not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for SLC7A7-ACIN1 |
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Fusion Gene PPI Analysis for SLC7A7-ACIN1 |
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Hgene | Hgene's interactors | Tgene | Tgene's interactors |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for SLC7A7-ACIN1 |
![]() (DrugBank Version 5.1.8 2021-05-08) |
Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for SLC7A7-ACIN1 |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
Hgene | SLC7A7 | C0268647 | Lysinuric Protein Intolerance | 10 | CTD_human;GENOMICS_ENGLAND;UNIPROT |
Hgene | SLC7A7 | C0002514 | Amino Acid Metabolism, Inborn Errors | 1 | CTD_human |
Hgene | SLC7A7 | C0750905 | Amino Acid Metabolism, Inherited Disorders | 1 | CTD_human |
Tgene | C3714756 | Intellectual Disability | 1 | GENOMICS_ENGLAND |