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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TIMM29-PDE4A (FusionGDB2 ID:HG90580TG5141)

Fusion Gene Summary for TIMM29-PDE4A

check button Fusion gene summary
Fusion gene informationFusion gene name: TIMM29-PDE4A
Fusion gene ID: hg90580tg5141
HgeneTgene
Gene symbol

TIMM29

PDE4A

Gene ID

90580

5141

Gene nametranslocase of inner mitochondrial membrane 29phosphodiesterase 4A
SynonymsC19orf52|TIM29DPDE2|PDE4|PDE46
Cytomap('C19orf52','TIMM29')('PDE4A','PDE4A')

19p13.2

19p13.2

Type of geneprotein-codingprotein-coding
Descriptionmitochondrial import inner membrane translocase subunit Tim29uncharacterized protein C19orf52cAMP-specific 3',5'-cyclic phosphodiesterase 4Aphosphodiesterase 4A, cAMP-specific (duncephosphodiesterase E2 dunce homolog, Drosophilaphosphodiesterase isozyme 4
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000270502, ENST00000593162, 
Fusion gene scores* DoF score2 X 3 X 2=129 X 9 X 8=648
# samples 212
** MAII scorelog2(2/12*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(12/648*10)=-2.43295940727611
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TIMM29 [Title/Abstract] AND PDE4A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointC19orf52(11040273)-PDE4A(10574469), # samples:1
C19orf52(11040684)-PDE4A(10574469), # samples:1
TIMM29(11040273)-PDE4A(10574469), # samples:1
Anticipated loss of major functional domain due to fusion event.C19orf52-PDE4A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C19orf52-PDE4A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
C19orf52-PDE4A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
C19orf52-PDE4A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneTIMM29

GO:0045039

protein import into mitochondrial inner membrane

28712724|28712726


check buttonFusion gene breakpoints across C19orf52 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PDE4A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-09-2054-01AC19orf52chr19

11040273

+PDE4Achr19

10574469

+
ChimerDB4OVTCGA-09-2054-01AC19orf52chr19

11040684

+PDE4Achr19

10574469

+
ChimerDB4OVTCGA-09-2054-01ATIMM29chr19

11040273

+PDE4Achr19

10574469

+


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Fusion Gene ORF analysis for TIMM29-PDE4A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000270502ENST00000293683C19orf52chr19

11040684

+PDE4Achr19

10574469

+
3UTR-3CDSENST00000270502ENST00000344979C19orf52chr19

11040684

+PDE4Achr19

10574469

+
3UTR-3CDSENST00000270502ENST00000352831C19orf52chr19

11040684

+PDE4Achr19

10574469

+
3UTR-3CDSENST00000270502ENST00000380702C19orf52chr19

11040684

+PDE4Achr19

10574469

+
3UTR-3CDSENST00000270502ENST00000440014C19orf52chr19

11040684

+PDE4Achr19

10574469

+
3UTR-3CDSENST00000270502ENST00000592685C19orf52chr19

11040684

+PDE4Achr19

10574469

+
In-frameENST00000270502ENST00000293683C19orf52chr19

11040273

+PDE4Achr19

10574469

+
In-frameENST00000270502ENST00000344979C19orf52chr19

11040273

+PDE4Achr19

10574469

+
In-frameENST00000270502ENST00000352831C19orf52chr19

11040273

+PDE4Achr19

10574469

+
In-frameENST00000270502ENST00000380702C19orf52chr19

11040273

+PDE4Achr19

10574469

+
In-frameENST00000270502ENST00000440014C19orf52chr19

11040273

+PDE4Achr19

10574469

+
In-frameENST00000270502ENST00000592685C19orf52chr19

11040273

+PDE4Achr19

10574469

+
intron-3CDSENST00000593162ENST00000293683C19orf52chr19

11040273

+PDE4Achr19

10574469

+
intron-3CDSENST00000593162ENST00000293683C19orf52chr19

11040684

+PDE4Achr19

10574469

+
intron-3CDSENST00000593162ENST00000344979C19orf52chr19

11040273

+PDE4Achr19

10574469

+
intron-3CDSENST00000593162ENST00000344979C19orf52chr19

11040684

+PDE4Achr19

10574469

+
intron-3CDSENST00000593162ENST00000352831C19orf52chr19

11040273

+PDE4Achr19

10574469

+
intron-3CDSENST00000593162ENST00000352831C19orf52chr19

11040684

+PDE4Achr19

10574469

+
intron-3CDSENST00000593162ENST00000380702C19orf52chr19

11040273

+PDE4Achr19

10574469

+
intron-3CDSENST00000593162ENST00000380702C19orf52chr19

11040684

+PDE4Achr19

10574469

+
intron-3CDSENST00000593162ENST00000440014C19orf52chr19

11040273

+PDE4Achr19

10574469

+
intron-3CDSENST00000593162ENST00000440014C19orf52chr19

11040684

+PDE4Achr19

10574469

+
intron-3CDSENST00000593162ENST00000592685C19orf52chr19

11040273

+PDE4Achr19

10574469

+
intron-3CDSENST00000593162ENST00000592685C19orf52chr19

11040684

+PDE4Achr19

10574469

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000270502C19orf52chr1911040273+ENST00000592685PDE4Achr1910574469+17878418531758301
ENST00000270502C19orf52chr1911040273+ENST00000380702PDE4Achr1910574469+37678418531758301
ENST00000270502C19orf52chr1911040273+ENST00000352831PDE4Achr1910574469+26318418531758301
ENST00000270502C19orf52chr1911040273+ENST00000293683PDE4Achr1910574469+17598418531758302
ENST00000270502C19orf52chr1911040273+ENST00000440014PDE4Achr1910574469+17598418531758302
ENST00000270502C19orf52chr1911040273+ENST00000344979PDE4Achr1910574469+20698418531758301

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000270502ENST00000592685C19orf52chr1911040273+PDE4Achr1910574469+0.0123979060.98760206
ENST00000270502ENST00000380702C19orf52chr1911040273+PDE4Achr1910574469+0.0072138950.9927861
ENST00000270502ENST00000352831C19orf52chr1911040273+PDE4Achr1910574469+0.0102916370.98970836
ENST00000270502ENST00000293683C19orf52chr1911040273+PDE4Achr1910574469+0.0129232470.9870768
ENST00000270502ENST00000440014C19orf52chr1911040273+PDE4Achr1910574469+0.0129232470.9870768
ENST00000270502ENST00000344979C19orf52chr1911040273+PDE4Achr1910574469+0.0102718740.98972815

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Fusion Genomic Features for TIMM29-PDE4A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for TIMM29-PDE4A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:11040273/:10574469)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePDE4Achr19:11040273chr19:10574469ENST00000344979710357_686342648.0DomainPDEase
TgenePDE4Achr19:11040273chr19:10574469ENST00000344979710433_437342648.0Nucleotide bindingcAMP

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneC19orf52chr19:11040273chr19:10574469ENST00000270502+1232_590261.0Topological domainMitochondrial matrix
HgeneC19orf52chr19:11040273chr19:10574469ENST00000270502+1278_2600261.0Topological domainMitochondrial intermembrane
HgeneC19orf52chr19:11040273chr19:10574469ENST00000270502+1260_770261.0TransmembraneHelical
TgenePDE4Achr19:11040273chr19:10574469ENST000002936831215357_686555861.0DomainPDEase
TgenePDE4Achr19:11040273chr19:10574469ENST000003528311215357_686581887.0DomainPDEase
TgenePDE4Achr19:11040273chr19:10574469ENST000003807021316357_686559865.0DomainPDEase
TgenePDE4Achr19:11040273chr19:10574469ENST000004400141215357_686520826.0DomainPDEase
TgenePDE4Achr19:11040273chr19:10574469ENST000005926851417357_686559865.0DomainPDEase
TgenePDE4Achr19:11040273chr19:10574469ENST000002936831215433_437555861.0Nucleotide bindingcAMP
TgenePDE4Achr19:11040273chr19:10574469ENST000003528311215433_437581887.0Nucleotide bindingcAMP
TgenePDE4Achr19:11040273chr19:10574469ENST000003807021316433_437559865.0Nucleotide bindingcAMP
TgenePDE4Achr19:11040273chr19:10574469ENST000004400141215433_437520826.0Nucleotide bindingcAMP
TgenePDE4Achr19:11040273chr19:10574469ENST000005926851417433_437559865.0Nucleotide bindingcAMP


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Fusion Gene Sequence for TIMM29-PDE4A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>11230_11230_1_C19orf52-PDE4A_C19orf52_chr19_11040273_ENST00000270502_PDE4A_chr19_10574469_ENST00000293683_length(transcript)=1759nt_BP=841nt
GTTGGCGCTTGCGCAGAAGAGACTCCCGGGCTCTTAACGTCGGGTATCAGGAGTTTCTTCCCGGAGCAAGGACCCCCAAGACGGAAGAGG
ATGGCCGCGGCGGCTCTGAGGAGATTTTGGTCCCGGCGCCGCGCAGAGGCGGGCGACGCGGTAGTGGCGAAGCCGGGAGTGTGGGCGCGG
CTGGGTGGACCAGGCGCTGTGGGAGGAGCAGGTCTTGCAGAAGGAGAAGAAGGACAGGCTCGCCCTGAGCCAGGCCCACTCGCTGGTGCA
GGCGGAGGCCCCGAGATGAAACCCTGAGGCCCCCGAGTCCTGGCAAACTGCTTGCCTGGGGTGGTGCAGTTCTGAGTGTGCCTCACCTGC
AGAACAGCTGAGACAGATGATGTGCAAAGTGTTTTCTCACTGGATTTGCACAAGTTTGGGGAGCCTTTCTGCCCCCCGTCTTTGTTCTTT
ATTAGCTGAAGCTAATTCAGAGCCACCTGGGTCCGGGAGTTGGGGACAGCAGAACGACTTGACACATGTTCATCACTGGCAGAGCTGGTC
ATGAGCCTTTTATATAAGCCTTTTTCATCGGGCCTCAGAGGCCCTCCTTAAGGAGGTACCACATTGGTCAGCTGACTTGCAAACTCTTCT
AAGGCCACTTAGATTTTCTTTTTCAAGTTTGGGTTGTGGCCTGGCATGGTGATGTCTGTAATCCCAGCAGTTTGCAAACTGAGGCAAGAG
AATCGCTTGAGGCCAGGAGTTTGAGGCCAGCTAGAGTGACATAGCAAGACTCCGATGCTACAAAAAAGAATAATAATAGTAATTAACTAA
ATAAAATTTGAGCTGAAATGTTTTTATTCTAGTCCTCCGGAACATGGTGCACTGTGCCGACCTCAGCAACCCCACCAAGCCGCTGGAGCT
GTACCGCCAGTGGACAGACCGCATCATGGCCGAGTTCTTCCAGCAGGGTGACCGAGAGCGCGAGCGTGGCATGGAAATCAGCCCCATGTG
TGACAAGCACACTGCCTCCGTGGAGAAGTCTCAGGTGGGTTTTATTGACTACATTGTGCACCCATTGTGGGAGACCTGGGCGGACCTTGT
CCACCCAGATGCCCAGGAGATCTTGGACACTTTGGAGGACAACCGGGACTGGTACTACAGCGCCATCCGGCAGAGCCCATCTCCGCCACC
CGAGGAGGAGTCAAGGGGGCCAGGCCACCCACCCCTGCCTGACAAGTTCCAGTTTGAGCTGACGCTGGAGGAGGAAGAGGAGGAAGAAAT
ATCAATGGCCCAGATACCGTGCACAGCCCAAGAGGCATTGACTGCGCAGGGATTGTCAGGAGTCGAGGAAGCTCTGGATGCAACCATAGC
CTGGGAGGCATCCCCGGCCCAGGAGTCGTTGGAAGTTATGGCACAGGAAGCATCCCTGGAGGCCGAGCTGGAGGCAGTGTATTTGACACA
GCAGGCACAGTCCACAGGCAGTGCACCTGTGGCTCCGGATGAGTTCTCGTCCCGGGAGGAATTCGTGGTTGCTGTAAGCCACAGCAGCCC
CTCTGCCCTGGCTCTTCAAAGCCCCCTTCTCCCTGCTTGGAGGACCCTGTCTGTTTCAGAGCATGCCCCGGGCCTCCCGGGCCTCCCCTC
CACGGCGGCCGAGGTGGAGGCCCAACGAGAGCACCAGGCTGCCAAGAGGGCTTGCAGTGCCTGCGCAGGGACATTTGGGGAGGACACATC
CGCACTCCCAGCTCCTGGTGGCGGGGGGTCAGGTGGAGACCCTACCTGA

>11230_11230_1_C19orf52-PDE4A_C19orf52_chr19_11040273_ENST00000270502_PDE4A_chr19_10574469_ENST00000293683_length(amino acids)=302AA_BP=
MVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDN
RDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMA
QEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAA
KRACSACAGTFGEDTSALPAPGGGGSGGDPTX

--------------------------------------------------------------
>11230_11230_2_C19orf52-PDE4A_C19orf52_chr19_11040273_ENST00000270502_PDE4A_chr19_10574469_ENST00000344979_length(transcript)=2069nt_BP=841nt
GTTGGCGCTTGCGCAGAAGAGACTCCCGGGCTCTTAACGTCGGGTATCAGGAGTTTCTTCCCGGAGCAAGGACCCCCAAGACGGAAGAGG
ATGGCCGCGGCGGCTCTGAGGAGATTTTGGTCCCGGCGCCGCGCAGAGGCGGGCGACGCGGTAGTGGCGAAGCCGGGAGTGTGGGCGCGG
CTGGGTGGACCAGGCGCTGTGGGAGGAGCAGGTCTTGCAGAAGGAGAAGAAGGACAGGCTCGCCCTGAGCCAGGCCCACTCGCTGGTGCA
GGCGGAGGCCCCGAGATGAAACCCTGAGGCCCCCGAGTCCTGGCAAACTGCTTGCCTGGGGTGGTGCAGTTCTGAGTGTGCCTCACCTGC
AGAACAGCTGAGACAGATGATGTGCAAAGTGTTTTCTCACTGGATTTGCACAAGTTTGGGGAGCCTTTCTGCCCCCCGTCTTTGTTCTTT
ATTAGCTGAAGCTAATTCAGAGCCACCTGGGTCCGGGAGTTGGGGACAGCAGAACGACTTGACACATGTTCATCACTGGCAGAGCTGGTC
ATGAGCCTTTTATATAAGCCTTTTTCATCGGGCCTCAGAGGCCCTCCTTAAGGAGGTACCACATTGGTCAGCTGACTTGCAAACTCTTCT
AAGGCCACTTAGATTTTCTTTTTCAAGTTTGGGTTGTGGCCTGGCATGGTGATGTCTGTAATCCCAGCAGTTTGCAAACTGAGGCAAGAG
AATCGCTTGAGGCCAGGAGTTTGAGGCCAGCTAGAGTGACATAGCAAGACTCCGATGCTACAAAAAAGAATAATAATAGTAATTAACTAA
ATAAAATTTGAGCTGAAATGTTTTTATTCTAGTCCTCCGGAACATGGTGCACTGTGCCGACCTCAGCAACCCCACCAAGCCGCTGGAGCT
GTACCGCCAGTGGACAGACCGCATCATGGCCGAGTTCTTCCAGCAGGGTGACCGAGAGCGCGAGCGTGGCATGGAAATCAGCCCCATGTG
TGACAAGCACACTGCCTCCGTGGAGAAGTCTCAGGTGGGTTTTATTGACTACATTGTGCACCCATTGTGGGAGACCTGGGCGGACCTTGT
CCACCCAGATGCCCAGGAGATCTTGGACACTTTGGAGGACAACCGGGACTGGTACTACAGCGCCATCCGGCAGAGCCCATCTCCGCCACC
CGAGGAGGAGTCAAGGGGGCCAGGCCACCCACCCCTGCCTGACAAGTTCCAGTTTGAGCTGACGCTGGAGGAGGAAGAGGAGGAAGAAAT
ATCAATGGCCCAGATACCGTGCACAGCCCAAGAGGCATTGACTGCGCAGGGATTGTCAGGAGTCGAGGAAGCTCTGGATGCAACCATAGC
CTGGGAGGCATCCCCGGCCCAGGAGTCGTTGGAAGTTATGGCACAGGAAGCATCCCTGGAGGCCGAGCTGGAGGCAGTGTATTTGACACA
GCAGGCACAGTCCACAGGCAGTGCACCTGTGGCTCCGGATGAGTTCTCGTCCCGGGAGGAATTCGTGGTTGCTGTAAGCCACAGCAGCCC
CTCTGCCCTGGCTCTTCAAAGCCCCCTTCTCCCTGCTTGGAGGACCCTGTCTGTTTCAGAGCATGCCCCGGGCCTCCCGGGCCTCCCCTC
CACGGCGGCCGAGGTGGAGGCCCAACGAGAGCACCAGGCTGCCAAGAGGGCTTGCAGTGCCTGCGCAGGGACATTTGGGGAGGACACATC
CGCACTCCCAGCTCCTGGTGGCGGGGGGTCAGGTGGAGACCCTACCTGATCCCCAGACCTCTGTCCCTGTTCCCCTCCACTCCTCCCCTC
ACTCCCCTGCTCCCCCGACCACCTCCTCCTCTGCCTCAAAGACTCTTGTCCTCTTGTCCCTCCTGAGAAAAAAGAAAACGAAAAGTGGGG
TTTTTTTCTGTTTTCTTTTTTTCCCCTTTCCCCCTGCCCCCACCCACGGGGCCTTTTTTTGGAGGTGGGGGCTGGGGAATGAGGGGCTGA
GGTCCCGGAAGGGATTTTATTTTTTTGAATTTTAATTGTAACATTTTTAGAAAAAGAACAAAAAAAGAAAAAAAAAAGAAAGAAACACA

>11230_11230_2_C19orf52-PDE4A_C19orf52_chr19_11040273_ENST00000270502_PDE4A_chr19_10574469_ENST00000344979_length(amino acids)=301AA_BP=
MVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDN
RDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMA
QEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAA
KRACSACAGTFGEDTSALPAPGGGGSGGDPT

--------------------------------------------------------------
>11230_11230_3_C19orf52-PDE4A_C19orf52_chr19_11040273_ENST00000270502_PDE4A_chr19_10574469_ENST00000352831_length(transcript)=2631nt_BP=841nt
GTTGGCGCTTGCGCAGAAGAGACTCCCGGGCTCTTAACGTCGGGTATCAGGAGTTTCTTCCCGGAGCAAGGACCCCCAAGACGGAAGAGG
ATGGCCGCGGCGGCTCTGAGGAGATTTTGGTCCCGGCGCCGCGCAGAGGCGGGCGACGCGGTAGTGGCGAAGCCGGGAGTGTGGGCGCGG
CTGGGTGGACCAGGCGCTGTGGGAGGAGCAGGTCTTGCAGAAGGAGAAGAAGGACAGGCTCGCCCTGAGCCAGGCCCACTCGCTGGTGCA
GGCGGAGGCCCCGAGATGAAACCCTGAGGCCCCCGAGTCCTGGCAAACTGCTTGCCTGGGGTGGTGCAGTTCTGAGTGTGCCTCACCTGC
AGAACAGCTGAGACAGATGATGTGCAAAGTGTTTTCTCACTGGATTTGCACAAGTTTGGGGAGCCTTTCTGCCCCCCGTCTTTGTTCTTT
ATTAGCTGAAGCTAATTCAGAGCCACCTGGGTCCGGGAGTTGGGGACAGCAGAACGACTTGACACATGTTCATCACTGGCAGAGCTGGTC
ATGAGCCTTTTATATAAGCCTTTTTCATCGGGCCTCAGAGGCCCTCCTTAAGGAGGTACCACATTGGTCAGCTGACTTGCAAACTCTTCT
AAGGCCACTTAGATTTTCTTTTTCAAGTTTGGGTTGTGGCCTGGCATGGTGATGTCTGTAATCCCAGCAGTTTGCAAACTGAGGCAAGAG
AATCGCTTGAGGCCAGGAGTTTGAGGCCAGCTAGAGTGACATAGCAAGACTCCGATGCTACAAAAAAGAATAATAATAGTAATTAACTAA
ATAAAATTTGAGCTGAAATGTTTTTATTCTAGTCCTCCGGAACATGGTGCACTGTGCCGACCTCAGCAACCCCACCAAGCCGCTGGAGCT
GTACCGCCAGTGGACAGACCGCATCATGGCCGAGTTCTTCCAGCAGGGTGACCGAGAGCGCGAGCGTGGCATGGAAATCAGCCCCATGTG
TGACAAGCACACTGCCTCCGTGGAGAAGTCTCAGGTGGGTTTTATTGACTACATTGTGCACCCATTGTGGGAGACCTGGGCGGACCTTGT
CCACCCAGATGCCCAGGAGATCTTGGACACTTTGGAGGACAACCGGGACTGGTACTACAGCGCCATCCGGCAGAGCCCATCTCCGCCACC
CGAGGAGGAGTCAAGGGGGCCAGGCCACCCACCCCTGCCTGACAAGTTCCAGTTTGAGCTGACGCTGGAGGAGGAAGAGGAGGAAGAAAT
ATCAATGGCCCAGATACCGTGCACAGCCCAAGAGGCATTGACTGCGCAGGGATTGTCAGGAGTCGAGGAAGCTCTGGATGCAACCATAGC
CTGGGAGGCATCCCCGGCCCAGGAGTCGTTGGAAGTTATGGCACAGGAAGCATCCCTGGAGGCCGAGCTGGAGGCAGTGTATTTGACACA
GCAGGCACAGTCCACAGGCAGTGCACCTGTGGCTCCGGATGAGTTCTCGTCCCGGGAGGAATTCGTGGTTGCTGTAAGCCACAGCAGCCC
CTCTGCCCTGGCTCTTCAAAGCCCCCTTCTCCCTGCTTGGAGGACCCTGTCTGTTTCAGAGCATGCCCCGGGCCTCCCGGGCCTCCCCTC
CACGGCGGCCGAGGTGGAGGCCCAACGAGAGCACCAGGCTGCCAAGAGGGCTTGCAGTGCCTGCGCAGGGACATTTGGGGAGGACACATC
CGCACTCCCAGCTCCTGGTGGCGGGGGGTCAGGTGGAGACCCTACCTGATCCCCAGACCTCTGTCCCTGTTCCCCTCCACTCCTCCCCTC
ACTCCCCTGCTCCCCCGACCACCTCCTCCTCTGCCTCAAAGACTCTTGTCCTCTTGTCCCTCCTGAGAAAAAAGAAAACGAAAAGTGGGG
TTTTTTTCTGTTTTCTTTTTTTCCCCTTTCCCCCTGCCCCCACCCACGGGGCCTTTTTTTGGAGGTGGGGGCTGGGGAATGAGGGGCTGA
GGTCCCGGAAGGGATTTTATTTTTTTGAATTTTAATTGTAACATTTTTAGAAAAAGAACAAAAAAAGAAAAAAAAAAGAAAGAAACACAG
CAACTGTAGATGCTCCTGTTCCTGGTTCCCGCTTTCCACTTCCAAATCCCTCCCCTCACCTTCCCCCACTGCCCCCCAAGTTCCAGGCTC
AGTCTTCCAGCCGCCTGGGGAGTCTCTACCTGGGCCCAAGCAGGTGTGGGGCCTCCTTCTGGGCTTTTCTTCTGAATTTAGAGGATTTCT
AGAACGTGGTCAGGAATAGCCATTCTAGGCGGGGCTGGGGCCAGGGTGGGGGGCAGTCACTGTGGGAGGTCCCAGCTCCAGCCCCCCTCT
GGTTTGCTGCCTCCTCTCCCCTCTAAAAAAGTCTTCCGCTTGATTTTGCACAATCCCGGCGATACTCCTGGCGATACTGACTAGAAAGTC
AGGGAGCTGGGGGAGCTGTTCACTTTAGGATACGGGGGTGGTATGGAAGGGAGCGTTCACACCGCCAGCCTCGGGCCTGGGATTTGAGGA
GGGCCCTAGACCTCCTCCACTCTCCATCCCCTTTCCCTTCCACTTTGGGTTCACTTTGAATTTTCTCCGTTTTTTGGGGCAGTGGCTCTG
ATCCACTCACCCCCCCGCCCC

>11230_11230_3_C19orf52-PDE4A_C19orf52_chr19_11040273_ENST00000270502_PDE4A_chr19_10574469_ENST00000352831_length(amino acids)=301AA_BP=
MVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDN
RDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMA
QEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAA
KRACSACAGTFGEDTSALPAPGGGGSGGDPT

--------------------------------------------------------------
>11230_11230_4_C19orf52-PDE4A_C19orf52_chr19_11040273_ENST00000270502_PDE4A_chr19_10574469_ENST00000380702_length(transcript)=3767nt_BP=841nt
GTTGGCGCTTGCGCAGAAGAGACTCCCGGGCTCTTAACGTCGGGTATCAGGAGTTTCTTCCCGGAGCAAGGACCCCCAAGACGGAAGAGG
ATGGCCGCGGCGGCTCTGAGGAGATTTTGGTCCCGGCGCCGCGCAGAGGCGGGCGACGCGGTAGTGGCGAAGCCGGGAGTGTGGGCGCGG
CTGGGTGGACCAGGCGCTGTGGGAGGAGCAGGTCTTGCAGAAGGAGAAGAAGGACAGGCTCGCCCTGAGCCAGGCCCACTCGCTGGTGCA
GGCGGAGGCCCCGAGATGAAACCCTGAGGCCCCCGAGTCCTGGCAAACTGCTTGCCTGGGGTGGTGCAGTTCTGAGTGTGCCTCACCTGC
AGAACAGCTGAGACAGATGATGTGCAAAGTGTTTTCTCACTGGATTTGCACAAGTTTGGGGAGCCTTTCTGCCCCCCGTCTTTGTTCTTT
ATTAGCTGAAGCTAATTCAGAGCCACCTGGGTCCGGGAGTTGGGGACAGCAGAACGACTTGACACATGTTCATCACTGGCAGAGCTGGTC
ATGAGCCTTTTATATAAGCCTTTTTCATCGGGCCTCAGAGGCCCTCCTTAAGGAGGTACCACATTGGTCAGCTGACTTGCAAACTCTTCT
AAGGCCACTTAGATTTTCTTTTTCAAGTTTGGGTTGTGGCCTGGCATGGTGATGTCTGTAATCCCAGCAGTTTGCAAACTGAGGCAAGAG
AATCGCTTGAGGCCAGGAGTTTGAGGCCAGCTAGAGTGACATAGCAAGACTCCGATGCTACAAAAAAGAATAATAATAGTAATTAACTAA
ATAAAATTTGAGCTGAAATGTTTTTATTCTAGTCCTCCGGAACATGGTGCACTGTGCCGACCTCAGCAACCCCACCAAGCCGCTGGAGCT
GTACCGCCAGTGGACAGACCGCATCATGGCCGAGTTCTTCCAGCAGGGTGACCGAGAGCGCGAGCGTGGCATGGAAATCAGCCCCATGTG
TGACAAGCACACTGCCTCCGTGGAGAAGTCTCAGGTGGGTTTTATTGACTACATTGTGCACCCATTGTGGGAGACCTGGGCGGACCTTGT
CCACCCAGATGCCCAGGAGATCTTGGACACTTTGGAGGACAACCGGGACTGGTACTACAGCGCCATCCGGCAGAGCCCATCTCCGCCACC
CGAGGAGGAGTCAAGGGGGCCAGGCCACCCACCCCTGCCTGACAAGTTCCAGTTTGAGCTGACGCTGGAGGAGGAAGAGGAGGAAGAAAT
ATCAATGGCCCAGATACCGTGCACAGCCCAAGAGGCATTGACTGCGCAGGGATTGTCAGGAGTCGAGGAAGCTCTGGATGCAACCATAGC
CTGGGAGGCATCCCCGGCCCAGGAGTCGTTGGAAGTTATGGCACAGGAAGCATCCCTGGAGGCCGAGCTGGAGGCAGTGTATTTGACACA
GCAGGCACAGTCCACAGGCAGTGCACCTGTGGCTCCGGATGAGTTCTCGTCCCGGGAGGAATTCGTGGTTGCTGTAAGCCACAGCAGCCC
CTCTGCCCTGGCTCTTCAAAGCCCCCTTCTCCCTGCTTGGAGGACCCTGTCTGTTTCAGAGCATGCCCCGGGCCTCCCGGGCCTCCCCTC
CACGGCGGCCGAGGTGGAGGCCCAACGAGAGCACCAGGCTGCCAAGAGGGCTTGCAGTGCCTGCGCAGGGACATTTGGGGAGGACACATC
CGCACTCCCAGCTCCTGGTGGCGGGGGGTCAGGTGGAGACCCTACCTGATCCCCAGACCTCTGTCCCTGTTCCCCTCCACTCCTCCCCTC
ACTCCCCTGCTCCCCCGACCACCTCCTCCTCTGCCTCAAAGACTCTTGTCCTCTTGTCCCTCCTGAGAAAAAAGAAAACGAAAAGTGGGG
TTTTTTTCTGTTTTCTTTTTTTCCCCTTTCCCCCTGCCCCCACCCACGGGGCCTTTTTTTGGAGGTGGGGGCTGGGGAATGAGGGGCTGA
GGTCCCGGAAGGGATTTTATTTTTTTGAATTTTAATTGTAACATTTTTAGAAAAAGAACAAAAAAAGAAAAAAAAAAGAAAGAAACACAG
CAACTGTAGATGCTCCTGTTCCTGGTTCCCGCTTTCCACTTCCAAATCCCTCCCCTCACCTTCCCCCACTGCCCCCCAAGTTCCAGGCTC
AGTCTTCCAGCCGCCTGGGGAGTCTCTACCTGGGCCCAAGCAGGTGTGGGGCCTCCTTCTGGGCTTTTCTTCTGAATTTAGAGGATTTCT
AGAACGTGGTCAGGAATAGCCATTCTAGGCGGGGCTGGGGCCAGGGTGGGGGGCAGTCACTGTGGGAGGTCCCAGCTCCAGCCCCCCTCT
GGTTTGCTGCCTCCTCTCCCCTCTAAAAAAGTCTTCCGCTTGATTTTGCACAATCCCGGCGATACTCCTGGCGATACTGACTAGAAAGTC
AGGGAGCTGGGGGAGCTGTTCACTTTAGGATACGGGGGTGGTATGGAAGGGAGCGTTCACACCGCCAGCCTCGGGCCTGGGATTTGAGGA
GGGCCCTAGACCTCCTCCACTCTCCATCCCCTTTCCCTTCCACTTTGGGTTCACTTTGAATTTTCTCCGTTTTTTGGGGCAGTGGCTCTG
ATCCACTCACCCCCCCGCCCCCCGCCCCACTTCTAGCTGCTTCTCCTCTTGTTTCTGCCTTAATAATTCCCACGGCCACAGGCAAGGGGG
TTGCAGTGGCCGCCTGCACCTTGGATGAGGCAGGGCCAGGCGCCCAGAACCCCCATCCTGGCCGCACCCCCCTTTCCAGGGTCCTCCGGA
CCCCACCTTCCACACTCTGATCACAGCCCCCCTACCTTTTGCCCTAGGAGGAAGCAATAATGGTGTATACCCTCATTCTCATTCCTGGGC
AGCCCTTCCTTCCACCCTGGCACCAAAATAATTTCTCCTCCATCCGTACCTTGCCTAGCCTCTCCCTCTCCCCCAGCTAGTCCCTGAGCA
ATACGGCAGACAGATGCAAGACCATTTTTCTCCAAGCCATGGGGGACTGTTTGGAAGGAAAGCCCCCTCTCTCCCTCCTCCCCTCGCCCT
CGGCCTGGTTCTGCAGCTGGACCGACCTCATTCATCGCCTGCCCCCTACCCAATTCTGAGCACACGGTACTGTAGCCCCCAGTTCCTCCC
TAGCCTTCCATCCCTCTGTCCACCCCAGGGGGAGGTAACCCCGCACTCACACTCCCTTGATGCTGTCTGTACAGGGTTCATATTTTGTAG
CGAAAGTCGTTTTTGTCCCAGCCGGCGATCGGAGTGGGCCTTTTCTTTCTTTTTGTTCATTCTTTACCTTTTTTTCTTTTCTTTCTTTCT
TTTTTGTACATACTGTAAGGTTGGTTTGTAAATTATTCTACGGAGGCAAAAAGGGAAAATAAAAACTTGCCCTTCCCTGGCTGACCCAGT
CGGGAAGGTAGGGAAGGAGGTCTCCCGTTGGGAGAGTCTCTGTTCCTGCTGTATTATACAAACTGTACCATAGTCCTGGGAAAAGGGTGG
ACTCACCGCTGTTGTTTTATGGGAAGTCGTGTCATCCTAGGGGTTGGGGCTGGGCAGAGCCTGTCCCCTCCCCCCTTCTCCAGGAGCCAG
GGGGTGACTGGAGAGACAGACCCACCCCCAAGCAGGGCTCCTCTCCCCAGGGTGAGCACAGGACCTCTGTAAGCTGCTTGTGTATTGTCC
ACTTTGACGATCAGTCATTCGGTCCGTTGATCAATAATCCTTCGATCTTGTCTCCAATTAAACCGAGGCTTTCACCG

>11230_11230_4_C19orf52-PDE4A_C19orf52_chr19_11040273_ENST00000270502_PDE4A_chr19_10574469_ENST00000380702_length(amino acids)=301AA_BP=
MVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDN
RDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMA
QEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAA
KRACSACAGTFGEDTSALPAPGGGGSGGDPT

--------------------------------------------------------------
>11230_11230_5_C19orf52-PDE4A_C19orf52_chr19_11040273_ENST00000270502_PDE4A_chr19_10574469_ENST00000440014_length(transcript)=1759nt_BP=841nt
GTTGGCGCTTGCGCAGAAGAGACTCCCGGGCTCTTAACGTCGGGTATCAGGAGTTTCTTCCCGGAGCAAGGACCCCCAAGACGGAAGAGG
ATGGCCGCGGCGGCTCTGAGGAGATTTTGGTCCCGGCGCCGCGCAGAGGCGGGCGACGCGGTAGTGGCGAAGCCGGGAGTGTGGGCGCGG
CTGGGTGGACCAGGCGCTGTGGGAGGAGCAGGTCTTGCAGAAGGAGAAGAAGGACAGGCTCGCCCTGAGCCAGGCCCACTCGCTGGTGCA
GGCGGAGGCCCCGAGATGAAACCCTGAGGCCCCCGAGTCCTGGCAAACTGCTTGCCTGGGGTGGTGCAGTTCTGAGTGTGCCTCACCTGC
AGAACAGCTGAGACAGATGATGTGCAAAGTGTTTTCTCACTGGATTTGCACAAGTTTGGGGAGCCTTTCTGCCCCCCGTCTTTGTTCTTT
ATTAGCTGAAGCTAATTCAGAGCCACCTGGGTCCGGGAGTTGGGGACAGCAGAACGACTTGACACATGTTCATCACTGGCAGAGCTGGTC
ATGAGCCTTTTATATAAGCCTTTTTCATCGGGCCTCAGAGGCCCTCCTTAAGGAGGTACCACATTGGTCAGCTGACTTGCAAACTCTTCT
AAGGCCACTTAGATTTTCTTTTTCAAGTTTGGGTTGTGGCCTGGCATGGTGATGTCTGTAATCCCAGCAGTTTGCAAACTGAGGCAAGAG
AATCGCTTGAGGCCAGGAGTTTGAGGCCAGCTAGAGTGACATAGCAAGACTCCGATGCTACAAAAAAGAATAATAATAGTAATTAACTAA
ATAAAATTTGAGCTGAAATGTTTTTATTCTAGTCCTCCGGAACATGGTGCACTGTGCCGACCTCAGCAACCCCACCAAGCCGCTGGAGCT
GTACCGCCAGTGGACAGACCGCATCATGGCCGAGTTCTTCCAGCAGGGTGACCGAGAGCGCGAGCGTGGCATGGAAATCAGCCCCATGTG
TGACAAGCACACTGCCTCCGTGGAGAAGTCTCAGGTGGGTTTTATTGACTACATTGTGCACCCATTGTGGGAGACCTGGGCGGACCTTGT
CCACCCAGATGCCCAGGAGATCTTGGACACTTTGGAGGACAACCGGGACTGGTACTACAGCGCCATCCGGCAGAGCCCATCTCCGCCACC
CGAGGAGGAGTCAAGGGGGCCAGGCCACCCACCCCTGCCTGACAAGTTCCAGTTTGAGCTGACGCTGGAGGAGGAAGAGGAGGAAGAAAT
ATCAATGGCCCAGATACCGTGCACAGCCCAAGAGGCATTGACTGCGCAGGGATTGTCAGGAGTCGAGGAAGCTCTGGATGCAACCATAGC
CTGGGAGGCATCCCCGGCCCAGGAGTCGTTGGAAGTTATGGCACAGGAAGCATCCCTGGAGGCCGAGCTGGAGGCAGTGTATTTGACACA
GCAGGCACAGTCCACAGGCAGTGCACCTGTGGCTCCGGATGAGTTCTCGTCCCGGGAGGAATTCGTGGTTGCTGTAAGCCACAGCAGCCC
CTCTGCCCTGGCTCTTCAAAGCCCCCTTCTCCCTGCTTGGAGGACCCTGTCTGTTTCAGAGCATGCCCCGGGCCTCCCGGGCCTCCCCTC
CACGGCGGCCGAGGTGGAGGCCCAACGAGAGCACCAGGCTGCCAAGAGGGCTTGCAGTGCCTGCGCAGGGACATTTGGGGAGGACACATC
CGCACTCCCAGCTCCTGGTGGCGGGGGGTCAGGTGGAGACCCTACCTGA

>11230_11230_5_C19orf52-PDE4A_C19orf52_chr19_11040273_ENST00000270502_PDE4A_chr19_10574469_ENST00000440014_length(amino acids)=302AA_BP=
MVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDN
RDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMA
QEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAA
KRACSACAGTFGEDTSALPAPGGGGSGGDPTX

--------------------------------------------------------------
>11230_11230_6_C19orf52-PDE4A_C19orf52_chr19_11040273_ENST00000270502_PDE4A_chr19_10574469_ENST00000592685_length(transcript)=1787nt_BP=841nt
GTTGGCGCTTGCGCAGAAGAGACTCCCGGGCTCTTAACGTCGGGTATCAGGAGTTTCTTCCCGGAGCAAGGACCCCCAAGACGGAAGAGG
ATGGCCGCGGCGGCTCTGAGGAGATTTTGGTCCCGGCGCCGCGCAGAGGCGGGCGACGCGGTAGTGGCGAAGCCGGGAGTGTGGGCGCGG
CTGGGTGGACCAGGCGCTGTGGGAGGAGCAGGTCTTGCAGAAGGAGAAGAAGGACAGGCTCGCCCTGAGCCAGGCCCACTCGCTGGTGCA
GGCGGAGGCCCCGAGATGAAACCCTGAGGCCCCCGAGTCCTGGCAAACTGCTTGCCTGGGGTGGTGCAGTTCTGAGTGTGCCTCACCTGC
AGAACAGCTGAGACAGATGATGTGCAAAGTGTTTTCTCACTGGATTTGCACAAGTTTGGGGAGCCTTTCTGCCCCCCGTCTTTGTTCTTT
ATTAGCTGAAGCTAATTCAGAGCCACCTGGGTCCGGGAGTTGGGGACAGCAGAACGACTTGACACATGTTCATCACTGGCAGAGCTGGTC
ATGAGCCTTTTATATAAGCCTTTTTCATCGGGCCTCAGAGGCCCTCCTTAAGGAGGTACCACATTGGTCAGCTGACTTGCAAACTCTTCT
AAGGCCACTTAGATTTTCTTTTTCAAGTTTGGGTTGTGGCCTGGCATGGTGATGTCTGTAATCCCAGCAGTTTGCAAACTGAGGCAAGAG
AATCGCTTGAGGCCAGGAGTTTGAGGCCAGCTAGAGTGACATAGCAAGACTCCGATGCTACAAAAAAGAATAATAATAGTAATTAACTAA
ATAAAATTTGAGCTGAAATGTTTTTATTCTAGTCCTCCGGAACATGGTGCACTGTGCCGACCTCAGCAACCCCACCAAGCCGCTGGAGCT
GTACCGCCAGTGGACAGACCGCATCATGGCCGAGTTCTTCCAGCAGGGTGACCGAGAGCGCGAGCGTGGCATGGAAATCAGCCCCATGTG
TGACAAGCACACTGCCTCCGTGGAGAAGTCTCAGGTGGGTTTTATTGACTACATTGTGCACCCATTGTGGGAGACCTGGGCGGACCTTGT
CCACCCAGATGCCCAGGAGATCTTGGACACTTTGGAGGACAACCGGGACTGGTACTACAGCGCCATCCGGCAGAGCCCATCTCCGCCACC
CGAGGAGGAGTCAAGGGGGCCAGGCCACCCACCCCTGCCTGACAAGTTCCAGTTTGAGCTGACGCTGGAGGAGGAAGAGGAGGAAGAAAT
ATCAATGGCCCAGATACCGTGCACAGCCCAAGAGGCATTGACTGCGCAGGGATTGTCAGGAGTCGAGGAAGCTCTGGATGCAACCATAGC
CTGGGAGGCATCCCCGGCCCAGGAGTCGTTGGAAGTTATGGCACAGGAAGCATCCCTGGAGGCCGAGCTGGAGGCAGTGTATTTGACACA
GCAGGCACAGTCCACAGGCAGTGCACCTGTGGCTCCGGATGAGTTCTCGTCCCGGGAGGAATTCGTGGTTGCTGTAAGCCACAGCAGCCC
CTCTGCCCTGGCTCTTCAAAGCCCCCTTCTCCCTGCTTGGAGGACCCTGTCTGTTTCAGAGCATGCCCCGGGCCTCCCGGGCCTCCCCTC
CACGGCGGCCGAGGTGGAGGCCCAACGAGAGCACCAGGCTGCCAAGAGGGCTTGCAGTGCCTGCGCAGGGACATTTGGGGAGGACACATC
CGCACTCCCAGCTCCTGGTGGCGGGGGGTCAGGTGGAGACCCTACCTGATCCCCAGACCTCTGTCCCTGTTCCCCTC

>11230_11230_6_C19orf52-PDE4A_C19orf52_chr19_11040273_ENST00000270502_PDE4A_chr19_10574469_ENST00000592685_length(amino acids)=301AA_BP=
MVHCADLSNPTKPLELYRQWTDRIMAEFFQQGDRERERGMEISPMCDKHTASVEKSQVGFIDYIVHPLWETWADLVHPDAQEILDTLEDN
RDWYYSAIRQSPSPPPEEESRGPGHPPLPDKFQFELTLEEEEEEEISMAQIPCTAQEALTAQGLSGVEEALDATIAWEASPAQESLEVMA
QEASLEAELEAVYLTQQAQSTGSAPVAPDEFSSREEFVVAVSHSSPSALALQSPLLPAWRTLSVSEHAPGLPGLPSTAAEVEAQREHQAA
KRACSACAGTFGEDTSALPAPGGGGSGGDPT

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TIMM29-PDE4A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TIMM29-PDE4A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TIMM29-PDE4A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0011570Mental Depression5PSYGENET
TgeneC0011581Depressive disorder5PSYGENET
TgeneC0036341Schizophrenia2PSYGENET
TgeneC0004352Autistic Disorder1CTD_human
TgeneC0005586Bipolar Disorder1PSYGENET
TgeneC0085159Seasonal Affective Disorder1PSYGENET