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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TBL1Y-GPR143 (FusionGDB2 ID:HG90665TG4935)

Fusion Gene Summary for TBL1Y-GPR143

check button Fusion gene summary
Fusion gene informationFusion gene name: TBL1Y-GPR143
Fusion gene ID: hg90665tg4935
HgeneTgene
Gene symbol

TBL1Y

GPR143

Gene ID

90665

4935

Gene nametransducin beta like 1 Y-linkedG protein-coupled receptor 143
SynonymsDFNY2|TBL1NYS6|OA1
Cytomap('TBL1Y')('GPR143')

Yp11.2

Xp22.2

Type of geneprotein-codingprotein-coding
DescriptionF-box-like/WD repeat-containing protein TBL1Ytransducin beta-like 1transducin beta-like protein 1Ytransducin-beta-like protein 1, Y-linkedG-protein coupled receptor 143ocular albinism 1ocular albinism type 1 protein
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000346432, ENST00000355162, 
ENST00000383032, 
Fusion gene scores* DoF score3 X 2 X 3=184 X 4 X 4=64
# samples 35
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(5/64*10)=-0.356143810225275
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TBL1Y [Title/Abstract] AND GPR143 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTBL1Y(6942661)-GPR143(9693880), # samples:1
Anticipated loss of major functional domain due to fusion event.TBL1Y-GPR143 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TBL1Y-GPR143 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TBL1Y-GPR143 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TBL1Y-GPR143 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TBL1Y-GPR143 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneGPR143

GO:0007186

G protein-coupled receptor signaling pathway

16524428

TgeneGPR143

GO:0032400

melanosome localization

19717472

TgeneGPR143

GO:0032402

melanosome transport

19717472

TgeneGPR143

GO:0035584

calcium-mediated signaling using intracellular calcium source

18828673

TgeneGPR143

GO:0048015

phosphatidylinositol-mediated signaling

16524428

TgeneGPR143

GO:0050848

regulation of calcium-mediated signaling

18828673


check buttonFusion gene breakpoints across TBL1Y (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across GPR143 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-CU-A3KJTBL1YchrY

6942661

+GPR143chrX

9693880

-


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Fusion Gene ORF analysis for TBL1Y-GPR143

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000346432ENST00000487206TBL1YchrY

6942661

+GPR143chrX

9693880

-
5CDS-intronENST00000355162ENST00000487206TBL1YchrY

6942661

+GPR143chrX

9693880

-
5CDS-intronENST00000383032ENST00000487206TBL1YchrY

6942661

+GPR143chrX

9693880

-
Frame-shiftENST00000346432ENST00000467482TBL1YchrY

6942661

+GPR143chrX

9693880

-
Frame-shiftENST00000355162ENST00000467482TBL1YchrY

6942661

+GPR143chrX

9693880

-
Frame-shiftENST00000383032ENST00000467482TBL1YchrY

6942661

+GPR143chrX

9693880

-
In-frameENST00000346432ENST00000380929TBL1YchrY

6942661

+GPR143chrX

9693880

-
In-frameENST00000355162ENST00000380929TBL1YchrY

6942661

+GPR143chrX

9693880

-
In-frameENST00000383032ENST00000380929TBL1YchrY

6942661

+GPR143chrX

9693880

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355162TBL1YchrY6942661+ENST00000380929GPR143chrX9693880-199815716161665349
ENST00000346432TBL1YchrY6942661+ENST00000380929GPR143chrX9693880-193415075521601349
ENST00000383032TBL1YchrY6942661+ENST00000380929GPR143chrX9693880-202916026471696349

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355162ENST00000380929TBL1YchrY6942661+GPR143chrX9693880-0.0046467090.99535334
ENST00000346432ENST00000380929TBL1YchrY6942661+GPR143chrX9693880-0.0038770060.996123
ENST00000383032ENST00000380929TBL1YchrY6942661+GPR143chrX9693880-0.0045457750.9954542

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Fusion Genomic Features for TBL1Y-GPR143


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for TBL1Y-GPR143


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrY:6942661/chrX:9693880)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBL1YchrY:6942661chrX:9693880ENST00000346432+121841_86318523.0DomainNote=F-box-like
HgeneTBL1YchrY:6942661chrX:9693880ENST00000346432+12184_36318523.0DomainLisH
HgeneTBL1YchrY:6942661chrX:9693880ENST00000355162+121841_86318523.0DomainNote=F-box-like
HgeneTBL1YchrY:6942661chrX:9693880ENST00000355162+12184_36318523.0DomainLisH
HgeneTBL1YchrY:6942661chrX:9693880ENST00000383032+131941_86318523.0DomainNote=F-box-like
HgeneTBL1YchrY:6942661chrX:9693880ENST00000383032+13194_36318523.0DomainLisH
HgeneTBL1YchrY:6942661chrX:9693880ENST00000346432+1218177_216318523.0RepeatNote=WD 1
HgeneTBL1YchrY:6942661chrX:9693880ENST00000346432+1218233_272318523.0RepeatNote=WD 2
HgeneTBL1YchrY:6942661chrX:9693880ENST00000346432+1218274_313318523.0RepeatNote=WD 3
HgeneTBL1YchrY:6942661chrX:9693880ENST00000355162+1218177_216318523.0RepeatNote=WD 1
HgeneTBL1YchrY:6942661chrX:9693880ENST00000355162+1218233_272318523.0RepeatNote=WD 2
HgeneTBL1YchrY:6942661chrX:9693880ENST00000355162+1218274_313318523.0RepeatNote=WD 3
HgeneTBL1YchrY:6942661chrX:9693880ENST00000383032+1319177_216318523.0RepeatNote=WD 1
HgeneTBL1YchrY:6942661chrX:9693880ENST00000383032+1319233_272318523.0RepeatNote=WD 2
HgeneTBL1YchrY:6942661chrX:9693880ENST00000383032+1319274_313318523.0RepeatNote=WD 3

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBL1YchrY:6942661chrX:9693880ENST00000346432+1218316_354318523.0RepeatNote=WD 4
HgeneTBL1YchrY:6942661chrX:9693880ENST00000346432+1218357_396318523.0RepeatNote=WD 5
HgeneTBL1YchrY:6942661chrX:9693880ENST00000346432+1218399_447318523.0RepeatNote=WD 6
HgeneTBL1YchrY:6942661chrX:9693880ENST00000346432+1218450_489318523.0RepeatNote=WD 7
HgeneTBL1YchrY:6942661chrX:9693880ENST00000346432+1218491_521318523.0RepeatNote=WD 8
HgeneTBL1YchrY:6942661chrX:9693880ENST00000355162+1218316_354318523.0RepeatNote=WD 4
HgeneTBL1YchrY:6942661chrX:9693880ENST00000355162+1218357_396318523.0RepeatNote=WD 5
HgeneTBL1YchrY:6942661chrX:9693880ENST00000355162+1218399_447318523.0RepeatNote=WD 6
HgeneTBL1YchrY:6942661chrX:9693880ENST00000355162+1218450_489318523.0RepeatNote=WD 7
HgeneTBL1YchrY:6942661chrX:9693880ENST00000355162+1218491_521318523.0RepeatNote=WD 8
HgeneTBL1YchrY:6942661chrX:9693880ENST00000383032+1319316_354318523.0RepeatNote=WD 4
HgeneTBL1YchrY:6942661chrX:9693880ENST00000383032+1319357_396318523.0RepeatNote=WD 5
HgeneTBL1YchrY:6942661chrX:9693880ENST00000383032+1319399_447318523.0RepeatNote=WD 6
HgeneTBL1YchrY:6942661chrX:9693880ENST00000383032+1319450_489318523.0RepeatNote=WD 7
HgeneTBL1YchrY:6942661chrX:9693880ENST00000383032+1319491_521318523.0RepeatNote=WD 8
TgeneGPR143chrY:6942661chrX:9693880ENST0000038092979222_231393425.0MotifNote=lysosomal/melanosomal membrane localization signal
TgeneGPR143chrY:6942661chrX:9693880ENST0000046748279222_231373405.0MotifNote=lysosomal/melanosomal membrane localization signal
TgeneGPR143chrY:6942661chrX:9693880ENST0000038092979221_238393425.0RegionNote=Necessary for its G protein-activation ability and normal distribution of melanosomes
TgeneGPR143chrY:6942661chrX:9693880ENST0000046748279221_238373405.0RegionNote=Necessary for its G protein-activation ability and normal distribution of melanosomes
TgeneGPR143chrY:6942661chrX:9693880ENST0000038092979100_124393425.0Topological domainExtracellular
TgeneGPR143chrY:6942661chrX:9693880ENST0000038092979146_149393425.0Topological domainCytoplasmic
TgeneGPR143chrY:6942661chrX:9693880ENST0000038092979171_191393425.0Topological domainExtracellular
TgeneGPR143chrY:6942661chrX:9693880ENST00000380929791_28393425.0Topological domainExtracellular
TgeneGPR143chrY:6942661chrX:9693880ENST0000038092979213_248393425.0Topological domainCytoplasmic
TgeneGPR143chrY:6942661chrX:9693880ENST0000038092979270_292393425.0Topological domainExtracellular
TgeneGPR143chrY:6942661chrX:9693880ENST0000038092979314_404393425.0Topological domainCytoplasmic
TgeneGPR143chrY:6942661chrX:9693880ENST000003809297950_78393425.0Topological domainCytoplasmic
TgeneGPR143chrY:6942661chrX:9693880ENST0000046748279100_124373405.0Topological domainExtracellular
TgeneGPR143chrY:6942661chrX:9693880ENST0000046748279146_149373405.0Topological domainCytoplasmic
TgeneGPR143chrY:6942661chrX:9693880ENST0000046748279171_191373405.0Topological domainExtracellular
TgeneGPR143chrY:6942661chrX:9693880ENST00000467482791_28373405.0Topological domainExtracellular
TgeneGPR143chrY:6942661chrX:9693880ENST0000046748279213_248373405.0Topological domainCytoplasmic
TgeneGPR143chrY:6942661chrX:9693880ENST0000046748279270_292373405.0Topological domainExtracellular
TgeneGPR143chrY:6942661chrX:9693880ENST0000046748279314_404373405.0Topological domainCytoplasmic
TgeneGPR143chrY:6942661chrX:9693880ENST000004674827950_78373405.0Topological domainCytoplasmic
TgeneGPR143chrY:6942661chrX:9693880ENST0000038092979125_145393425.0TransmembraneHelical%3B Name%3D3
TgeneGPR143chrY:6942661chrX:9693880ENST0000038092979150_170393425.0TransmembraneHelical%3B Name%3D4
TgeneGPR143chrY:6942661chrX:9693880ENST0000038092979192_212393425.0TransmembraneHelical%3B Name%3D5
TgeneGPR143chrY:6942661chrX:9693880ENST0000038092979249_269393425.0TransmembraneHelical%3B Name%3D6
TgeneGPR143chrY:6942661chrX:9693880ENST0000038092979293_313393425.0TransmembraneHelical%3B Name%3D7
TgeneGPR143chrY:6942661chrX:9693880ENST000003809297929_49393425.0TransmembraneHelical%3B Name%3D1
TgeneGPR143chrY:6942661chrX:9693880ENST000003809297979_99393425.0TransmembraneHelical%3B Name%3D2
TgeneGPR143chrY:6942661chrX:9693880ENST0000046748279125_145373405.0TransmembraneHelical%3B Name%3D3
TgeneGPR143chrY:6942661chrX:9693880ENST0000046748279150_170373405.0TransmembraneHelical%3B Name%3D4
TgeneGPR143chrY:6942661chrX:9693880ENST0000046748279192_212373405.0TransmembraneHelical%3B Name%3D5
TgeneGPR143chrY:6942661chrX:9693880ENST0000046748279249_269373405.0TransmembraneHelical%3B Name%3D6
TgeneGPR143chrY:6942661chrX:9693880ENST0000046748279293_313373405.0TransmembraneHelical%3B Name%3D7
TgeneGPR143chrY:6942661chrX:9693880ENST000004674827929_49373405.0TransmembraneHelical%3B Name%3D1
TgeneGPR143chrY:6942661chrX:9693880ENST000004674827979_99373405.0TransmembraneHelical%3B Name%3D2


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Fusion Gene Sequence for TBL1Y-GPR143


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>89580_89580_1_TBL1Y-GPR143_TBL1Y_chrY_6942661_ENST00000346432_GPR143_chrX_9693880_ENST00000380929_length(transcript)=1934nt_BP=1507nt
CCAGTGCCCCCAATTCGCGCTCGGGAGTGAGGAGCCGCCAACACCCCAGCTCCGCTGCTGCCGCCACCGCAGTGCTCTCTAGTCGCCATT
GGTTACCTAAACTTTCCAGTACCCGCGACCTTTCCGGGACTCCGCGGCGGCGGGGCAGAGGCGGCCCAGGGGCGGCACGCGGCTGCTCCG
GTGCGCCGGGCTCTTTTCGGCCGCCGCACGGCCGGGCCTCACAGGCTGCCCTCCTGAGAGAGGCTCAGAACACGGCCAGGTACGCGCCGC
CGCCACAGTTGCGCTGCTAGCGACGAGGTGTTTTCCTCTGCTGGCACGCCAGAATCCCTGGTTCAGCCTGGAAGGCGAGGGGCAGGACTC
CCCAGACAGTGGCCTCAGTGTGGCATTGATGTCCTAGGTTGTAAGGTGCTAAGGCTGGTCCCCACAGACGGCTTGCCATTTCTATGACTG
GATGCTGAGAAGCCTGCTGGTTCAGAGGTCCACACATGAAGTTACCATAAAGAGGGTGGTTCCAACTTCATCAATACCTCATCGCCATGA
GGTGAGGCTAAGATGAGCATAACCAGTGACGAGGTGAACTTTCTGGTTTATCGGTATCTCCAGGAGTCAGGTTTTTCTCACTCGGCTTTC
ACGTTTGGGATCGAGAGCCACATCAGCCAGTCCAACATCAATGGGACACTAGTGCCACCGTCTGCCCTCATCTCCATTCTCCAGAAGGGA
CTGCAGTATGTAGAGGCTGAGATAAGCATCAACAAGGATGGCACAGTGTTCGACAGCCGCCCTATAGAGTCCCTGTCCCTGATAGTTGCT
GTGATTCCTGATGTGGTGCAGATGCGGCAGCAGGCATTTGGAGAGAAGCTCACTCAGCAGCAAGCCAGTGCAGCAGCCACAGAGGCATCA
GCAATGGCAAAGGCGGCAACCATGACCCCAGCTGCTATTTCCCAGCAAAATCCTCCAAAGAACCGAGAGGCCACAGTGAACGGGGAAGAG
AATGGAGCACATGAAATCAATAATCACTCAAAGCCAATGGAAATAGATGGGGATGTTGAGATTCCACCCAACAAAGCCACAGTCCTTCGG
GGCCACGAGTCTGAGGTGTTCATTTGTGCCTGGAACCCTGTCAGTGATTTGCTAGCCTCTGGATCTGGAGACTCAACTGCAAGGATATGG
AACCTGAATGAGAATAGCAACGGGGGCTCCACCCAGCTCGTGTTGAGACATTGTATACGAGAAGGGGGGCACGACGTCCCAAGTAATAAA
GATGTCACCTCACTGGACTGGAACAGTGATGGAACACTATTGGCTATGGGTTCATATGATGGTTTCGCAAGAATATGGACAGAAAATGGT
AACCTGGCCAGCACCTTAGGCCAACATAAAGGCCCCATCTTCGCTCTGAAATGGAACAAAAAGGGGAATTATGTTTTGAGTGCTGGTGTA
GACAAAACAACAATAATTTGGGATGCTCACACAGGAGAAGCCAAACAGCAGTTTCCTTTTCATTCAGGTTCTGATGCCAGCACAATTGAA
ATTCACACTGCAAGTGAATCCTGCAACAAAAATGAGGGTGACCCTGCTCTCCCAACCCATGGAGACCTATGAAGGGGATGTGCTGGGGGT
CCAGACCCCATATTCCTCAGACTCAACAATTCTTGTTCTTTAGAACTGTGTTCTCACCTTCCCAACACTGCACTGCCGAAGTGTAGCGGC
CCCCAAACCTTGCTCTCATCACCAGCTAGAGCTTCTTCCCGAAGGGCCTTTAGGATAGGAGAAAGGGTTCATGCACACACGTGTGAGAAT
GGAAGAGCCCCCTCCAGACCACTCTACAGCTGCTCTAGCCTTAGTTGCCACTAGGAAGTTTTCTGAGGCTGGCTGTAAAGTAAGTGTAAG
GTCCACATCCTTGGGGAAGTAGTTAAATAAAATAGTTATGACTG

>89580_89580_1_TBL1Y-GPR143_TBL1Y_chrY_6942661_ENST00000346432_GPR143_chrX_9693880_ENST00000380929_length(amino acids)=349AA_BP=318
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYVEAEISINKDGTVFDSRPIESLSLIVAVIPD
VVQMRQQAFGEKLTQQQASAAATEASAMAKAATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHES
EVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLAS
TLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSGSDASTIEIHTASESCNKNEGDPALPTHGDL

--------------------------------------------------------------
>89580_89580_2_TBL1Y-GPR143_TBL1Y_chrY_6942661_ENST00000355162_GPR143_chrX_9693880_ENST00000380929_length(transcript)=1998nt_BP=1571nt
CCAGTGCCCCCAATTCGCGCTCGGGAGTGAGGAGCCGCCAACACCCCAGCTCCGCTGCTGCCGCCACCGCAGTGCTCTCTAGTCGCCATT
GGTTACCTAAACTTTCCAGTACCCGCGACCTTTCCGGGACTCCGCGGCGGCGGGGCAGAGGCGGCCCAGGGGCGGCACGCGGCTGCTCCG
GTGCGCCGGGCTCTTTTCGGCCGCCGCACGGCCGGGCCTCACAGGCTGCCCTCCTGAGAGAGGCTCAGAACACGGCCAGGTACGCGCCGC
CGCCACAGTTGCGCTGCTAGCGACGAGGTGTTTTCCTCTGCTGGCACGCCAGAATCCCTGGTTCAGCCTGGAAGGCGAGGGGCAGGACTC
CCCAGACAGTGGCCTCAGTGTGGGGAATGCCAGCTGTTCTCTTAACAGAAGGGCAGTTTTTGAAGAAATGAAGCAGGACTTGATGTGGAT
TGTCATAAACTGTTTCTCCCTAAAGAGGCTGGTCCCCACAGACGGCTTGCCATTTCTATGACTGGATGCTGAGAAGCCTGCTGGTTCAGA
GGTCCACACATGAAGTTACCATAAAGAGGGTGGTTCCAACTTCATCAATACCTCATCGCCATGAGGTGAGGCTAAGATGAGCATAACCAG
TGACGAGGTGAACTTTCTGGTTTATCGGTATCTCCAGGAGTCAGGTTTTTCTCACTCGGCTTTCACGTTTGGGATCGAGAGCCACATCAG
CCAGTCCAACATCAATGGGACACTAGTGCCACCGTCTGCCCTCATCTCCATTCTCCAGAAGGGACTGCAGTATGTAGAGGCTGAGATAAG
CATCAACAAGGATGGCACAGTGTTCGACAGCCGCCCTATAGAGTCCCTGTCCCTGATAGTTGCTGTGATTCCTGATGTGGTGCAGATGCG
GCAGCAGGCATTTGGAGAGAAGCTCACTCAGCAGCAAGCCAGTGCAGCAGCCACAGAGGCATCAGCAATGGCAAAGGCGGCAACCATGAC
CCCAGCTGCTATTTCCCAGCAAAATCCTCCAAAGAACCGAGAGGCCACAGTGAACGGGGAAGAGAATGGAGCACATGAAATCAATAATCA
CTCAAAGCCAATGGAAATAGATGGGGATGTTGAGATTCCACCCAACAAAGCCACAGTCCTTCGGGGCCACGAGTCTGAGGTGTTCATTTG
TGCCTGGAACCCTGTCAGTGATTTGCTAGCCTCTGGATCTGGAGACTCAACTGCAAGGATATGGAACCTGAATGAGAATAGCAACGGGGG
CTCCACCCAGCTCGTGTTGAGACATTGTATACGAGAAGGGGGGCACGACGTCCCAAGTAATAAAGATGTCACCTCACTGGACTGGAACAG
TGATGGAACACTATTGGCTATGGGTTCATATGATGGTTTCGCAAGAATATGGACAGAAAATGGTAACCTGGCCAGCACCTTAGGCCAACA
TAAAGGCCCCATCTTCGCTCTGAAATGGAACAAAAAGGGGAATTATGTTTTGAGTGCTGGTGTAGACAAAACAACAATAATTTGGGATGC
TCACACAGGAGAAGCCAAACAGCAGTTTCCTTTTCATTCAGGTTCTGATGCCAGCACAATTGAAATTCACACTGCAAGTGAATCCTGCAA
CAAAAATGAGGGTGACCCTGCTCTCCCAACCCATGGAGACCTATGAAGGGGATGTGCTGGGGGTCCAGACCCCATATTCCTCAGACTCAA
CAATTCTTGTTCTTTAGAACTGTGTTCTCACCTTCCCAACACTGCACTGCCGAAGTGTAGCGGCCCCCAAACCTTGCTCTCATCACCAGC
TAGAGCTTCTTCCCGAAGGGCCTTTAGGATAGGAGAAAGGGTTCATGCACACACGTGTGAGAATGGAAGAGCCCCCTCCAGACCACTCTA
CAGCTGCTCTAGCCTTAGTTGCCACTAGGAAGTTTTCTGAGGCTGGCTGTAAAGTAAGTGTAAGGTCCACATCCTTGGGGAAGTAGTTAA
ATAAAATAGTTATGACTG

>89580_89580_2_TBL1Y-GPR143_TBL1Y_chrY_6942661_ENST00000355162_GPR143_chrX_9693880_ENST00000380929_length(amino acids)=349AA_BP=318
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYVEAEISINKDGTVFDSRPIESLSLIVAVIPD
VVQMRQQAFGEKLTQQQASAAATEASAMAKAATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHES
EVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLAS
TLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSGSDASTIEIHTASESCNKNEGDPALPTHGDL

--------------------------------------------------------------
>89580_89580_3_TBL1Y-GPR143_TBL1Y_chrY_6942661_ENST00000383032_GPR143_chrX_9693880_ENST00000380929_length(transcript)=2029nt_BP=1602nt
CCAGTGCCCCCAATTCGCGCTCGGGAGTGAGGAGCCGCCAACACCCCAGCTCCGCTGCTGCCGCCACCGCAGTGCTCTCTAGTCGCCATT
GGTTACCTAAACTTTCCAGTACCCGCGACCTTTCCGGGACTCCGCGGCGGCGGGGCAGAGGCGGCCCAGGGGCGGCACGCGGCTGCTCCG
GTGCGCCGGGCTCTTTTCGGCCGCCGCACGGCCGGGCCTCACAGGCTGCCCTCCTGAGAGAGGCTCAGAACACGGCCAGGTACGCGCCGC
CGCCACAGTTGCGCTGCTAGCGACGAGGTGTTTTCCTCTGCTGGCACGCCAGAATCCCTGGTTCAGCCTGGAAGGCGAGGGGCAGGACTC
CCCAGACAGTGGCCTCAGTGTGGCATTGATGTCCTAGGTTGTAAGGTGCTAAGGGGAATGCCAGCTGTTCTCTTAACAGAAGGGCAGTTT
TTGAAGAAATGAAGCAGGACTTGATGTGGATTGTCATAAACTGTTTCTCCCTAAAGAGGCTGGTCCCCACAGACGGCTTGCCATTTCTAT
GACTGGATGCTGAGAAGCCTGCTGGTTCAGAGGTCCACACATGAAGTTACCATAAAGAGGGTGGTTCCAACTTCATCAATACCTCATCGC
CATGAGGTGAGGCTAAGATGAGCATAACCAGTGACGAGGTGAACTTTCTGGTTTATCGGTATCTCCAGGAGTCAGGTTTTTCTCACTCGG
CTTTCACGTTTGGGATCGAGAGCCACATCAGCCAGTCCAACATCAATGGGACACTAGTGCCACCGTCTGCCCTCATCTCCATTCTCCAGA
AGGGACTGCAGTATGTAGAGGCTGAGATAAGCATCAACAAGGATGGCACAGTGTTCGACAGCCGCCCTATAGAGTCCCTGTCCCTGATAG
TTGCTGTGATTCCTGATGTGGTGCAGATGCGGCAGCAGGCATTTGGAGAGAAGCTCACTCAGCAGCAAGCCAGTGCAGCAGCCACAGAGG
CATCAGCAATGGCAAAGGCGGCAACCATGACCCCAGCTGCTATTTCCCAGCAAAATCCTCCAAAGAACCGAGAGGCCACAGTGAACGGGG
AAGAGAATGGAGCACATGAAATCAATAATCACTCAAAGCCAATGGAAATAGATGGGGATGTTGAGATTCCACCCAACAAAGCCACAGTCC
TTCGGGGCCACGAGTCTGAGGTGTTCATTTGTGCCTGGAACCCTGTCAGTGATTTGCTAGCCTCTGGATCTGGAGACTCAACTGCAAGGA
TATGGAACCTGAATGAGAATAGCAACGGGGGCTCCACCCAGCTCGTGTTGAGACATTGTATACGAGAAGGGGGGCACGACGTCCCAAGTA
ATAAAGATGTCACCTCACTGGACTGGAACAGTGATGGAACACTATTGGCTATGGGTTCATATGATGGTTTCGCAAGAATATGGACAGAAA
ATGGTAACCTGGCCAGCACCTTAGGCCAACATAAAGGCCCCATCTTCGCTCTGAAATGGAACAAAAAGGGGAATTATGTTTTGAGTGCTG
GTGTAGACAAAACAACAATAATTTGGGATGCTCACACAGGAGAAGCCAAACAGCAGTTTCCTTTTCATTCAGGTTCTGATGCCAGCACAA
TTGAAATTCACACTGCAAGTGAATCCTGCAACAAAAATGAGGGTGACCCTGCTCTCCCAACCCATGGAGACCTATGAAGGGGATGTGCTG
GGGGTCCAGACCCCATATTCCTCAGACTCAACAATTCTTGTTCTTTAGAACTGTGTTCTCACCTTCCCAACACTGCACTGCCGAAGTGTA
GCGGCCCCCAAACCTTGCTCTCATCACCAGCTAGAGCTTCTTCCCGAAGGGCCTTTAGGATAGGAGAAAGGGTTCATGCACACACGTGTG
AGAATGGAAGAGCCCCCTCCAGACCACTCTACAGCTGCTCTAGCCTTAGTTGCCACTAGGAAGTTTTCTGAGGCTGGCTGTAAAGTAAGT
GTAAGGTCCACATCCTTGGGGAAGTAGTTAAATAAAATAGTTATGACTG

>89580_89580_3_TBL1Y-GPR143_TBL1Y_chrY_6942661_ENST00000383032_GPR143_chrX_9693880_ENST00000380929_length(amino acids)=349AA_BP=318
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYVEAEISINKDGTVFDSRPIESLSLIVAVIPD
VVQMRQQAFGEKLTQQQASAAATEASAMAKAATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHES
EVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLAS
TLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSGSDASTIEIHTASESCNKNEGDPALPTHGDL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for TBL1Y-GPR143


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TBL1Y-GPR143


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TBL1Y-GPR143


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0342684Ocular albinism, type I14CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC3151752NYSTAGMUS 6, CONGENITAL, X-LINKED3CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneC0015397Disorder of eye1GENOMICS_ENGLAND
TgeneC0028738Nystagmus1GENOMICS_ENGLAND
TgeneC1963184Nystagmus, CTCAE 3.01GENOMICS_ENGLAND
TgeneC4554036Nystagmus, CTCAE 5.01GENOMICS_ENGLAND