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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:TBL1Y-USP13 (FusionGDB2 ID:HG90665TG8975)

Fusion Gene Summary for TBL1Y-USP13

check button Fusion gene summary
Fusion gene informationFusion gene name: TBL1Y-USP13
Fusion gene ID: hg90665tg8975
HgeneTgene
Gene symbol

TBL1Y

USP13

Gene ID

90665

8975

Gene nametransducin beta like 1 Y-linkedubiquitin specific peptidase 13
SynonymsDFNY2|TBL1ISOT3|IsoT-3
Cytomap('TBL1Y')('USP13')

Yp11.2

3q26.33

Type of geneprotein-codingprotein-coding
DescriptionF-box-like/WD repeat-containing protein TBL1Ytransducin beta-like 1transducin beta-like protein 1Ytransducin-beta-like protein 1, Y-linkedubiquitin carboxyl-terminal hydrolase 13deubiquitinating enzyme 13ubiquitin specific peptidase 13 (isopeptidase T-3)ubiquitin specific protease 13 (isopeptidase T-3)ubiquitin thioesterase 13ubiquitin thiolesterase 13ubiquitin-specific-processing pro
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000346432, ENST00000355162, 
ENST00000383032, 
Fusion gene scores* DoF score3 X 2 X 3=184 X 4 X 3=48
# samples 34
** MAII scorelog2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: TBL1Y [Title/Abstract] AND USP13 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointTBL1Y(6942661)-USP13(179478899), # samples:1
Anticipated loss of major functional domain due to fusion event.TBL1Y-USP13 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TBL1Y-USP13 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
TBL1Y-USP13 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
TBL1Y-USP13 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneUSP13

GO:0010506

regulation of autophagy

21962518

TgeneUSP13

GO:0035523

protein K29-linked deubiquitination

26280536

TgeneUSP13

GO:0044313

protein K6-linked deubiquitination

26280536

TgeneUSP13

GO:0050821

protein stabilization

21659512|26280536

TgeneUSP13

GO:0070536

protein K63-linked deubiquitination

22216260|26280536


check buttonFusion gene breakpoints across TBL1Y (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across USP13 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A07GTBL1YchrY

6942661

+USP13chr3

179478899

+


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Fusion Gene ORF analysis for TBL1Y-USP13

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000346432ENST00000482333TBL1YchrY

6942661

+USP13chr3

179478899

+
5CDS-intronENST00000346432ENST00000496897TBL1YchrY

6942661

+USP13chr3

179478899

+
5CDS-intronENST00000355162ENST00000482333TBL1YchrY

6942661

+USP13chr3

179478899

+
5CDS-intronENST00000355162ENST00000496897TBL1YchrY

6942661

+USP13chr3

179478899

+
5CDS-intronENST00000383032ENST00000482333TBL1YchrY

6942661

+USP13chr3

179478899

+
5CDS-intronENST00000383032ENST00000496897TBL1YchrY

6942661

+USP13chr3

179478899

+
In-frameENST00000346432ENST00000263966TBL1YchrY

6942661

+USP13chr3

179478899

+
In-frameENST00000355162ENST00000263966TBL1YchrY

6942661

+USP13chr3

179478899

+
In-frameENST00000383032ENST00000263966TBL1YchrY

6942661

+USP13chr3

179478899

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000355162TBL1YchrY6942661+ENST00000263966USP13chr3179478899+747515716162214532
ENST00000346432TBL1YchrY6942661+ENST00000263966USP13chr3179478899+741115075522150532
ENST00000383032TBL1YchrY6942661+ENST00000263966USP13chr3179478899+750616026472245532

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000355162ENST00000263966TBL1YchrY6942661+USP13chr3179478899+0.0014184210.99858165
ENST00000346432ENST00000263966TBL1YchrY6942661+USP13chr3179478899+0.0014205330.9985795
ENST00000383032ENST00000263966TBL1YchrY6942661+USP13chr3179478899+0.0014093450.99859065

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Fusion Genomic Features for TBL1Y-USP13


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
TBL1YchrY6942661+USP13chr3179478899+1.37E-060.9999987
TBL1YchrY6942661+USP13chr3179478899+1.37E-060.9999987

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for TBL1Y-USP13


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrY:6942661/chr3:179478899)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBL1YchrY:6942661chr3:179478899ENST00000346432+121841_86318523.0DomainNote=F-box-like
HgeneTBL1YchrY:6942661chr3:179478899ENST00000346432+12184_36318523.0DomainLisH
HgeneTBL1YchrY:6942661chr3:179478899ENST00000355162+121841_86318523.0DomainNote=F-box-like
HgeneTBL1YchrY:6942661chr3:179478899ENST00000355162+12184_36318523.0DomainLisH
HgeneTBL1YchrY:6942661chr3:179478899ENST00000383032+131941_86318523.0DomainNote=F-box-like
HgeneTBL1YchrY:6942661chr3:179478899ENST00000383032+13194_36318523.0DomainLisH
HgeneTBL1YchrY:6942661chr3:179478899ENST00000346432+1218177_216318523.0RepeatNote=WD 1
HgeneTBL1YchrY:6942661chr3:179478899ENST00000346432+1218233_272318523.0RepeatNote=WD 2
HgeneTBL1YchrY:6942661chr3:179478899ENST00000346432+1218274_313318523.0RepeatNote=WD 3
HgeneTBL1YchrY:6942661chr3:179478899ENST00000355162+1218177_216318523.0RepeatNote=WD 1
HgeneTBL1YchrY:6942661chr3:179478899ENST00000355162+1218233_272318523.0RepeatNote=WD 2
HgeneTBL1YchrY:6942661chr3:179478899ENST00000355162+1218274_313318523.0RepeatNote=WD 3
HgeneTBL1YchrY:6942661chr3:179478899ENST00000383032+1319177_216318523.0RepeatNote=WD 1
HgeneTBL1YchrY:6942661chr3:179478899ENST00000383032+1319233_272318523.0RepeatNote=WD 2
HgeneTBL1YchrY:6942661chr3:179478899ENST00000383032+1319274_313318523.0RepeatNote=WD 3
TgeneUSP13chrY:6942661chr3:179478899ENST000002639661521652_693649864.0DomainUBA 1
TgeneUSP13chrY:6942661chr3:179478899ENST000002639661521727_767649864.0DomainUBA 2
TgeneUSP13chrY:6942661chr3:179478899ENST000004968971521652_693584799.0DomainUBA 1
TgeneUSP13chrY:6942661chr3:179478899ENST000004968971521727_767584799.0DomainUBA 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneTBL1YchrY:6942661chr3:179478899ENST00000346432+1218316_354318523.0RepeatNote=WD 4
HgeneTBL1YchrY:6942661chr3:179478899ENST00000346432+1218357_396318523.0RepeatNote=WD 5
HgeneTBL1YchrY:6942661chr3:179478899ENST00000346432+1218399_447318523.0RepeatNote=WD 6
HgeneTBL1YchrY:6942661chr3:179478899ENST00000346432+1218450_489318523.0RepeatNote=WD 7
HgeneTBL1YchrY:6942661chr3:179478899ENST00000346432+1218491_521318523.0RepeatNote=WD 8
HgeneTBL1YchrY:6942661chr3:179478899ENST00000355162+1218316_354318523.0RepeatNote=WD 4
HgeneTBL1YchrY:6942661chr3:179478899ENST00000355162+1218357_396318523.0RepeatNote=WD 5
HgeneTBL1YchrY:6942661chr3:179478899ENST00000355162+1218399_447318523.0RepeatNote=WD 6
HgeneTBL1YchrY:6942661chr3:179478899ENST00000355162+1218450_489318523.0RepeatNote=WD 7
HgeneTBL1YchrY:6942661chr3:179478899ENST00000355162+1218491_521318523.0RepeatNote=WD 8
HgeneTBL1YchrY:6942661chr3:179478899ENST00000383032+1319316_354318523.0RepeatNote=WD 4
HgeneTBL1YchrY:6942661chr3:179478899ENST00000383032+1319357_396318523.0RepeatNote=WD 5
HgeneTBL1YchrY:6942661chr3:179478899ENST00000383032+1319399_447318523.0RepeatNote=WD 6
HgeneTBL1YchrY:6942661chr3:179478899ENST00000383032+1319450_489318523.0RepeatNote=WD 7
HgeneTBL1YchrY:6942661chr3:179478899ENST00000383032+1319491_521318523.0RepeatNote=WD 8
TgeneUSP13chrY:6942661chr3:179478899ENST000002639661521336_861649864.0DomainNote=USP
TgeneUSP13chrY:6942661chr3:179478899ENST000004968971521336_861584799.0DomainNote=USP
TgeneUSP13chrY:6942661chr3:179478899ENST000002639661521209_281649864.0Zinc fingerUBP-type
TgeneUSP13chrY:6942661chr3:179478899ENST000004968971521209_281584799.0Zinc fingerUBP-type


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Fusion Gene Sequence for TBL1Y-USP13


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>89581_89581_1_TBL1Y-USP13_TBL1Y_chrY_6942661_ENST00000346432_USP13_chr3_179478899_ENST00000263966_length(transcript)=7411nt_BP=1507nt
CCAGTGCCCCCAATTCGCGCTCGGGAGTGAGGAGCCGCCAACACCCCAGCTCCGCTGCTGCCGCCACCGCAGTGCTCTCTAGTCGCCATT
GGTTACCTAAACTTTCCAGTACCCGCGACCTTTCCGGGACTCCGCGGCGGCGGGGCAGAGGCGGCCCAGGGGCGGCACGCGGCTGCTCCG
GTGCGCCGGGCTCTTTTCGGCCGCCGCACGGCCGGGCCTCACAGGCTGCCCTCCTGAGAGAGGCTCAGAACACGGCCAGGTACGCGCCGC
CGCCACAGTTGCGCTGCTAGCGACGAGGTGTTTTCCTCTGCTGGCACGCCAGAATCCCTGGTTCAGCCTGGAAGGCGAGGGGCAGGACTC
CCCAGACAGTGGCCTCAGTGTGGCATTGATGTCCTAGGTTGTAAGGTGCTAAGGCTGGTCCCCACAGACGGCTTGCCATTTCTATGACTG
GATGCTGAGAAGCCTGCTGGTTCAGAGGTCCACACATGAAGTTACCATAAAGAGGGTGGTTCCAACTTCATCAATACCTCATCGCCATGA
GGTGAGGCTAAGATGAGCATAACCAGTGACGAGGTGAACTTTCTGGTTTATCGGTATCTCCAGGAGTCAGGTTTTTCTCACTCGGCTTTC
ACGTTTGGGATCGAGAGCCACATCAGCCAGTCCAACATCAATGGGACACTAGTGCCACCGTCTGCCCTCATCTCCATTCTCCAGAAGGGA
CTGCAGTATGTAGAGGCTGAGATAAGCATCAACAAGGATGGCACAGTGTTCGACAGCCGCCCTATAGAGTCCCTGTCCCTGATAGTTGCT
GTGATTCCTGATGTGGTGCAGATGCGGCAGCAGGCATTTGGAGAGAAGCTCACTCAGCAGCAAGCCAGTGCAGCAGCCACAGAGGCATCA
GCAATGGCAAAGGCGGCAACCATGACCCCAGCTGCTATTTCCCAGCAAAATCCTCCAAAGAACCGAGAGGCCACAGTGAACGGGGAAGAG
AATGGAGCACATGAAATCAATAATCACTCAAAGCCAATGGAAATAGATGGGGATGTTGAGATTCCACCCAACAAAGCCACAGTCCTTCGG
GGCCACGAGTCTGAGGTGTTCATTTGTGCCTGGAACCCTGTCAGTGATTTGCTAGCCTCTGGATCTGGAGACTCAACTGCAAGGATATGG
AACCTGAATGAGAATAGCAACGGGGGCTCCACCCAGCTCGTGTTGAGACATTGTATACGAGAAGGGGGGCACGACGTCCCAAGTAATAAA
GATGTCACCTCACTGGACTGGAACAGTGATGGAACACTATTGGCTATGGGTTCATATGATGGTTTCGCAAGAATATGGACAGAAAATGGT
AACCTGGCCAGCACCTTAGGCCAACATAAAGGCCCCATCTTCGCTCTGAAATGGAACAAAAAGGGGAATTATGTTTTGAGTGCTGGTGTA
GACAAAACAACAATAATTTGGGATGCTCACACAGGAGAAGCCAAACAGCAGTTTCCTTTTCATTCAGCATCAGACATCGATGAGTCATCA
GTGATGCAGCTGGCCGAGATGGGTTTCCCGCTGGAAGCATGTCGCAAGGCTGTGTACTTCACTGGAAATATGGGCGCCGAGGTGGCCTTC
AACTGGATCATTGTTCACATGGAAGAGCCAGATTTTGCTGAGCCGCTGACCATGCCTGGTTATGGAGGGGCAGCTTCTGCTGGAGCCTCT
GTTTTTGGTGCTTCTGGACTGGATAACCAACCTCCAGAGGAAATCGTAGCTATCATCACCTCCATGGGATTTCAGCGAAATCAGGCTATT
CAGGCACTACGAGCAACGAATAATAACCTGGAAAGAGCACTGGATTGGATCTTTAGCCACCCTGAGTTTGAAGAAGACAGTGATTTTGTG
ATTGAGATGGAGAATAATGCCAATGCAAACATTATTTCTGAGGCCAAGCCCGAAGGACCTAGAGTCAAGGATGGATCTGGAACATATGAG
CTATTTGCATTCATCAGTCACATGGGAACATCCACAATGAGTGGTCATTACATTTGCCATATCAAAAAGGAAGGAAGATGGGTGATTTAC
AATGACCACAAAGTTTGTGCCTCAGAAAGGCCCCCTAAAGACCTGGGCTACATGTACTTTTACCGCAGGATACCAAGCTAAACCTCAAAT
ATAAAAATTGGCGAAAAGAAGCCATACGCCTTTTTAATTTGCCAAAAAAAAAAAGAAGAAGAAGAAGTTGAAACAACTAGACATGAAGGA
ATATATGGGGTATTTATCGTTTATTTAAAGAGCACGATCAGTTGACACCTTCTGAAATAGAACTGAGAAGAAATTTCTATTAGTGATGAT
ACACTATTATATTGTAGATAGTTTTTATAAATGTTCAAAAAGATGATGATATTTAAAAACAAAAAAAGTATTCATATTGCTGGTGGAGGA
TCTGCCATCAGCACATCAAAAATGGGGATGTGCCCCCAGCCCTCTATTTTGCTTTGGGGGTCAGTGATAGTGGCCTCTGGAGAAACCAAA
TAATGTGGCCAGTGGTGTGGCCTTACCCACAACAAATGAAAAGCCCACTTGTGTTTCATATAGAAAATCAGCAGTTGGGTGGGGCTTTAT
TTGTGACATAATTTTTTTCATGACATACAATAATTTCTGATGTATCCATGTAGATATTATGCTCTGTCCATAATAGAGCCTCTGCAATGA
AAGATATTTTTAATTTGTCACATTAAAATTCATAATACGATTGTGTGAATGTGTGTGAGACTGACTGAGAGTGTGAGACTTTTACTAGAA
AAGTGAGTCCACTAGAAAATCTGTGACAAGTTGGTTTTTAAAGTCTGAACAGTTGATATTAAGCATATCTGAAAAAAGCAAGTAAATATT
TTAACAAAACTATGACTCAGGAACCTTCGAGAAGATTAGTTCCCCACTTAGATTTTTAAGGAGTAAAAAGGGCTGAGTTATGCCTTTAAG
TGCTGTCAAGAATTCACTTGGGTTTGGGACATTTGCTGGTGTAATGCTAGATGCCCACAGCAGCATAATATTGTACTTTGTCAAAGGTAG
GTAAATTCTCTGTTTCTCAGCAGCCCTTTCCCCAAAAGGTATGGTGTTTATTTTTAGTAAAAATAGCTAATCTCTTTTTACCATCTCACA
TGATAACTCTTTGGAGTCATGTCAAGTGCCCCAAATTTGTCTGTGATTTTCCCATCTCTGAGCTCTTTATCTGCCTCCGTTTCCTTGTTT
TTCTGGGGCCAGAGTCTCATCTCTGCCTTTTTTTGGTGTATCACCTTCTGACTTGCCTTCATTGCTTGTCTGATGTGACCAACAGTGTGA
TCTTGGACACACTAAGGATTTTAGATGCAAAGAAACTTTATACAACATTATGAAAGACTATCCTTTCCATTTTGGTTATTTCAGCATTTT
AGTTGCAACCTGGGATTAGATTAGAGTTTCCAACGTGATGAAAAGTGGAATGATAGCATTCTATAATTTCCATAATTTTCCTACTGGTCC
GTACCAAATTCTAGAGTCTCTGGAGTTGCTATTTCAGAGTATTTGGTCAAACGAAAAAGAATTTATTGCTGTCTGTTTAACATGTATTTG
TTTGGTTGAAAGGATCTTTTTAGAAACTGTAGGAAAATAAACAGAACCAACCAGGTGAAACAAAGCACAGACATTGGGTTAGGATGTAGT
GAGTTGTGAACAATCAGGATTCTGGGTGTGATGGGGGTCCCTGTCTCATAGGTGATCCTTTGGTGCCATGTGACCGAGAGACATGGTGTC
TAAGGCCCATGGCCTGGAGACCTGGGTGCTGCTCCTAGCTGACTGTGGACCTTGGGCAAGTCCTTCATCCGTCCTGTGCCTCACTGTCCT
CATCTGAACAATGGTATGATGACACCTGCCCTCTCTTTCAATCATGCTTTGAGGATACAGTGAGATTGGTTACAGTGAACCTTCAATGAG
TAGAATGTGGTATGCCATGGTGGGTTGTAGTAGATGGTGCTCCCTGCCTTTTCTCCTCTGTTTTCCTCAATTTGGGAACAAATGAGATTG
GCAGAAGGAGGGAGCTCACGGTGCAGTACTTTTCTACCAAAGTGTGCCCACTGGTGTCACCTCCTAATGTTAACTTGGATTTCCTAAAGC
AGTCCCACTCTGTTATGAGAGTCACTGACTCCCGTGGACATCCCCACAGTAAGCAGCCTTACAAAATCCAGTCCCCTTAGGGCAGAGTGA
GTGTCATAGAATAATGACTCCAAACCCACGTCAAAAATGGCTTGTTTTCAGCGATGTTATAAAACAAAGGCCTGTTTTTTGGAATTGGGG
GTGACTGGGTGGTTTGGATTGAAATGTGGACAAAGATAGCATGTGTATTTTGAATAAAATAAAAATTTTGTAATAAAACTTTTAAAAATC
AGTGATGTAAAATCAATATTTAAGACTATAGGCTATAAATTGTTTGATTTCATTAACTAGCCCTTTTGATGCCTAGACATGTTGTAAAAA
AATTGTGCTATGGCTGCCTTTTCTTCTGCCCCACAACACAAAGGGCTATTTCTACAAGGCAAAGTTTTGTATATGTGCTATTCTTTACTT
CAGATTGAGAGTTGGGAAAAACTGGAGTAAATAATGGGTTTCTTACTTGCTTAAAAGCATATTTATATGTGTATCTCAATATATACAAGG
CAGGTTCCCCTATAAAAGTCTGGAATGTACTGCTTAATTTTACACTTGTGTAGACACGATTATTTGTGACTGAAAAGTGGAATAACGTGT
GGATTTTGTCAACTCATTATCAGTCTGTTAGCAGTCCTCTATGTGAGGCATGGTGGTCTAATTGTGAAATTCTCCCTGTATATGGGTGTC
TGTGTGAAAGACAGCACTTTCTTCCTGTAAATATCTTTTGATATCCATTTATGTAGAATTCCAATGAATATGTCTTTGGAAAAGGTAATG
TATCAAAGTTTTTATTTTGCCAATTGATCTAAATGCCCATATAACTAATCAGAAATCCAGTTTGGTTCAGATTGGGATTTTCTTTTAAAG
AAAAAAAAAGTATGCAGAAAAGACTATTGGAAGAATCATGTGTTAGTGACACTTTACATCAACGTTGCTTCAATATTTTGGAATTGACCA
GGCTGCTTTCTCCTACCTGCAAGAGAATGTGCCTGACATTTCCCAGTGCTTACTTTGGGCTATAGGAAGTCCAGCGGGGATAGCTCGAGC
CTCTTGCTCCCTGAGTCATTTATTCCCTTTACCTGAACAGAGCCTTACCTGCAATTCATAGTGAGAGCACCTGGGTCTGTATCCTGACTC
CACTCTAAGTGAGGTGGGACTGAATCACTGTACCTCTCTGGGCCTTTTCATTTGAAACAAGTGGGTTAGACTAGATTAGCTCCAAAGTCC
TCTCTTGCCCTAACATTTTATTTTTATTTTCCTGTGGTTACCACTAGGGTCTGACACGTAAAATGTGAGGGATCACTTAGAGGTTTGGAT
GTTATATTTTTGCATTGTTACAGCTTATACTCCCCAGTTGAGGACCTGTGTCATTCTTAGTGGCCCCACGACCCCTCTGTTTGTATTCCT
GCTCCACTTATCTATACTTTTTTGGGTAATCATCCCACTTTTTTTTTTTCTTGAGATGGAGTCTCGCTGTGTTGCCAAGGCTGGAGTACA
GTGGTGCAATCTCAGCTCACTGCAGCCTCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCTTCCCAAGTAGCTGGGATTACTGGCGCAC
GCCACTACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCTTGACCTCAACCT
GCCTCAGCCTCCCAAAGTGCTGGGATTACACGCATGAGCTACCGCGTCCAGCCCCACTTTTTTTCTACTCTTGAAAAAAACAACTTTCTA
GTCCATGAGGTACTTTGGCTCCATCCCCCTCAAAAACAAAACAAAAAATCCATTTAAAGTGTCCTCCTAGAAAAGCCTCAGAACTGCCTT
CAACTACATCTGTCACCTTTATAGAATATTTTGAAATTCTGGAAGAGGATGGGAAACAAAATTCTAATTTAGCTAGAGCTGTGATCCCCA
AATAAGTGCTGACAAAATTGTCTACCACAGAAAGGCCGTCCTTGTCATCTTGTAGGCATCACTGCTGCTAAATCACATCAGTACATGCCT
TCTGTGGGGAGATGGCAGGGGGCAGGGGCAGGACCAGGGGATGGGATTAGATAAAGTGTGATAATGTCCTTTAGATAAAAGAAATCCTAC
GCTATAGAACAAGGTTCTGTACTCTTGAGTTGGTGTCTGAGATCACCTGCACAGTGTTACAGAGATTTTCCACTCCATAAATCACTCTAA
AAGAGTTTGCATAAGACTCGGTAGACCTGTGCTATTCAATGTGGCAGTCAACAGCCATATGTGGCGATGACTACTCAAAGTTTGGCTTGT
TCAAATCGAGACTGTGTTGTACACATACAATACACACCAGATTTTGAAGGCTTGGTACCAAAAAGGAATTTAAAATATTTCACCAATATT
TCATATTGATAACATGCTGAAATGACACTATTTTGGATGTACTAAGTAAAATATTAACAATTTAATATATTTATATAATTGAAATTAAAA
TTCTTTTCACCCATTTTTATTTTTTTAAAAATGTGGCCCCTAAAGAACTTCAAATTAGACATGTGGATAACGTTATACTTCTATTGGACA
GCCCCACTCTAGACTTACATGGTGTGGGGTAGGCAGTGAAATCCGTAAATAGGAAACGCAATTCTGCAAAGTATCTAAATAGACAGAAAC
AACACAAATATTTTTGCTGGAGTCAGGAGCACTGTGAGGCACAGAACATCTCCCAGAAAGCAGATTTTTTTTTTCTGCCGAAAAACCAAT
ATATATATGTATGATCCCAATTAAAAGACAAAAGCAAATGAGCCCCAAACTGCCTGTCTTCAGCTTTGCCTGGGAGCTGCTACCTTTGCT
CTTCTAGCATCTTCTAGGTACCAAGGATATTAGCCACTTGAGGGTGTTGGGCATATTTGTTTCATTGTAGGCAAAATCCTCTTGTGGTTT
CCCCTCCCCAGGTATTGTTGAGTCTGTTCAAAGCTGGGTGTGTTGAAACACTGCACAAATCCTGCCACTCTTGATGTGCCGCTTGTCTCA
GCCTTGGCAGAGGCTGAGTCTGTTCCTGTGCCCACCTGTCCAGCAGGTTTTGATGTTGGCTCCTGAAAGAGTTTGTATTTATTTTATTTT
GCACTAGTCACAGTTGTTGTTAAACTGTATCAAATGTTTTGGGAGATTATTTGCCTGAGATGGAAAGAGAGATGGATGATTTATTGCTTC
AATTGTTTTAAATTAAAAGCTATTCTCACAA

>89581_89581_1_TBL1Y-USP13_TBL1Y_chrY_6942661_ENST00000346432_USP13_chr3_179478899_ENST00000263966_length(amino acids)=532AA_BP=318
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYVEAEISINKDGTVFDSRPIESLSLIVAVIPD
VVQMRQQAFGEKLTQQQASAAATEASAMAKAATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHES
EVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLAS
TLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSASDIDESSVMQLAEMGFPLEACRKAVYFTGNMGAEVAFNWII
VHMEEPDFAEPLTMPGYGGAASAGASVFGASGLDNQPPEEIVAIITSMGFQRNQAIQALRATNNNLERALDWIFSHPEFEEDSDFVIEME
NNANANIISEAKPEGPRVKDGSGTYELFAFISHMGTSTMSGHYICHIKKEGRWVIYNDHKVCASERPPKDLGYMYFYRRIPS

--------------------------------------------------------------
>89581_89581_2_TBL1Y-USP13_TBL1Y_chrY_6942661_ENST00000355162_USP13_chr3_179478899_ENST00000263966_length(transcript)=7475nt_BP=1571nt
CCAGTGCCCCCAATTCGCGCTCGGGAGTGAGGAGCCGCCAACACCCCAGCTCCGCTGCTGCCGCCACCGCAGTGCTCTCTAGTCGCCATT
GGTTACCTAAACTTTCCAGTACCCGCGACCTTTCCGGGACTCCGCGGCGGCGGGGCAGAGGCGGCCCAGGGGCGGCACGCGGCTGCTCCG
GTGCGCCGGGCTCTTTTCGGCCGCCGCACGGCCGGGCCTCACAGGCTGCCCTCCTGAGAGAGGCTCAGAACACGGCCAGGTACGCGCCGC
CGCCACAGTTGCGCTGCTAGCGACGAGGTGTTTTCCTCTGCTGGCACGCCAGAATCCCTGGTTCAGCCTGGAAGGCGAGGGGCAGGACTC
CCCAGACAGTGGCCTCAGTGTGGGGAATGCCAGCTGTTCTCTTAACAGAAGGGCAGTTTTTGAAGAAATGAAGCAGGACTTGATGTGGAT
TGTCATAAACTGTTTCTCCCTAAAGAGGCTGGTCCCCACAGACGGCTTGCCATTTCTATGACTGGATGCTGAGAAGCCTGCTGGTTCAGA
GGTCCACACATGAAGTTACCATAAAGAGGGTGGTTCCAACTTCATCAATACCTCATCGCCATGAGGTGAGGCTAAGATGAGCATAACCAG
TGACGAGGTGAACTTTCTGGTTTATCGGTATCTCCAGGAGTCAGGTTTTTCTCACTCGGCTTTCACGTTTGGGATCGAGAGCCACATCAG
CCAGTCCAACATCAATGGGACACTAGTGCCACCGTCTGCCCTCATCTCCATTCTCCAGAAGGGACTGCAGTATGTAGAGGCTGAGATAAG
CATCAACAAGGATGGCACAGTGTTCGACAGCCGCCCTATAGAGTCCCTGTCCCTGATAGTTGCTGTGATTCCTGATGTGGTGCAGATGCG
GCAGCAGGCATTTGGAGAGAAGCTCACTCAGCAGCAAGCCAGTGCAGCAGCCACAGAGGCATCAGCAATGGCAAAGGCGGCAACCATGAC
CCCAGCTGCTATTTCCCAGCAAAATCCTCCAAAGAACCGAGAGGCCACAGTGAACGGGGAAGAGAATGGAGCACATGAAATCAATAATCA
CTCAAAGCCAATGGAAATAGATGGGGATGTTGAGATTCCACCCAACAAAGCCACAGTCCTTCGGGGCCACGAGTCTGAGGTGTTCATTTG
TGCCTGGAACCCTGTCAGTGATTTGCTAGCCTCTGGATCTGGAGACTCAACTGCAAGGATATGGAACCTGAATGAGAATAGCAACGGGGG
CTCCACCCAGCTCGTGTTGAGACATTGTATACGAGAAGGGGGGCACGACGTCCCAAGTAATAAAGATGTCACCTCACTGGACTGGAACAG
TGATGGAACACTATTGGCTATGGGTTCATATGATGGTTTCGCAAGAATATGGACAGAAAATGGTAACCTGGCCAGCACCTTAGGCCAACA
TAAAGGCCCCATCTTCGCTCTGAAATGGAACAAAAAGGGGAATTATGTTTTGAGTGCTGGTGTAGACAAAACAACAATAATTTGGGATGC
TCACACAGGAGAAGCCAAACAGCAGTTTCCTTTTCATTCAGCATCAGACATCGATGAGTCATCAGTGATGCAGCTGGCCGAGATGGGTTT
CCCGCTGGAAGCATGTCGCAAGGCTGTGTACTTCACTGGAAATATGGGCGCCGAGGTGGCCTTCAACTGGATCATTGTTCACATGGAAGA
GCCAGATTTTGCTGAGCCGCTGACCATGCCTGGTTATGGAGGGGCAGCTTCTGCTGGAGCCTCTGTTTTTGGTGCTTCTGGACTGGATAA
CCAACCTCCAGAGGAAATCGTAGCTATCATCACCTCCATGGGATTTCAGCGAAATCAGGCTATTCAGGCACTACGAGCAACGAATAATAA
CCTGGAAAGAGCACTGGATTGGATCTTTAGCCACCCTGAGTTTGAAGAAGACAGTGATTTTGTGATTGAGATGGAGAATAATGCCAATGC
AAACATTATTTCTGAGGCCAAGCCCGAAGGACCTAGAGTCAAGGATGGATCTGGAACATATGAGCTATTTGCATTCATCAGTCACATGGG
AACATCCACAATGAGTGGTCATTACATTTGCCATATCAAAAAGGAAGGAAGATGGGTGATTTACAATGACCACAAAGTTTGTGCCTCAGA
AAGGCCCCCTAAAGACCTGGGCTACATGTACTTTTACCGCAGGATACCAAGCTAAACCTCAAATATAAAAATTGGCGAAAAGAAGCCATA
CGCCTTTTTAATTTGCCAAAAAAAAAAAGAAGAAGAAGAAGTTGAAACAACTAGACATGAAGGAATATATGGGGTATTTATCGTTTATTT
AAAGAGCACGATCAGTTGACACCTTCTGAAATAGAACTGAGAAGAAATTTCTATTAGTGATGATACACTATTATATTGTAGATAGTTTTT
ATAAATGTTCAAAAAGATGATGATATTTAAAAACAAAAAAAGTATTCATATTGCTGGTGGAGGATCTGCCATCAGCACATCAAAAATGGG
GATGTGCCCCCAGCCCTCTATTTTGCTTTGGGGGTCAGTGATAGTGGCCTCTGGAGAAACCAAATAATGTGGCCAGTGGTGTGGCCTTAC
CCACAACAAATGAAAAGCCCACTTGTGTTTCATATAGAAAATCAGCAGTTGGGTGGGGCTTTATTTGTGACATAATTTTTTTCATGACAT
ACAATAATTTCTGATGTATCCATGTAGATATTATGCTCTGTCCATAATAGAGCCTCTGCAATGAAAGATATTTTTAATTTGTCACATTAA
AATTCATAATACGATTGTGTGAATGTGTGTGAGACTGACTGAGAGTGTGAGACTTTTACTAGAAAAGTGAGTCCACTAGAAAATCTGTGA
CAAGTTGGTTTTTAAAGTCTGAACAGTTGATATTAAGCATATCTGAAAAAAGCAAGTAAATATTTTAACAAAACTATGACTCAGGAACCT
TCGAGAAGATTAGTTCCCCACTTAGATTTTTAAGGAGTAAAAAGGGCTGAGTTATGCCTTTAAGTGCTGTCAAGAATTCACTTGGGTTTG
GGACATTTGCTGGTGTAATGCTAGATGCCCACAGCAGCATAATATTGTACTTTGTCAAAGGTAGGTAAATTCTCTGTTTCTCAGCAGCCC
TTTCCCCAAAAGGTATGGTGTTTATTTTTAGTAAAAATAGCTAATCTCTTTTTACCATCTCACATGATAACTCTTTGGAGTCATGTCAAG
TGCCCCAAATTTGTCTGTGATTTTCCCATCTCTGAGCTCTTTATCTGCCTCCGTTTCCTTGTTTTTCTGGGGCCAGAGTCTCATCTCTGC
CTTTTTTTGGTGTATCACCTTCTGACTTGCCTTCATTGCTTGTCTGATGTGACCAACAGTGTGATCTTGGACACACTAAGGATTTTAGAT
GCAAAGAAACTTTATACAACATTATGAAAGACTATCCTTTCCATTTTGGTTATTTCAGCATTTTAGTTGCAACCTGGGATTAGATTAGAG
TTTCCAACGTGATGAAAAGTGGAATGATAGCATTCTATAATTTCCATAATTTTCCTACTGGTCCGTACCAAATTCTAGAGTCTCTGGAGT
TGCTATTTCAGAGTATTTGGTCAAACGAAAAAGAATTTATTGCTGTCTGTTTAACATGTATTTGTTTGGTTGAAAGGATCTTTTTAGAAA
CTGTAGGAAAATAAACAGAACCAACCAGGTGAAACAAAGCACAGACATTGGGTTAGGATGTAGTGAGTTGTGAACAATCAGGATTCTGGG
TGTGATGGGGGTCCCTGTCTCATAGGTGATCCTTTGGTGCCATGTGACCGAGAGACATGGTGTCTAAGGCCCATGGCCTGGAGACCTGGG
TGCTGCTCCTAGCTGACTGTGGACCTTGGGCAAGTCCTTCATCCGTCCTGTGCCTCACTGTCCTCATCTGAACAATGGTATGATGACACC
TGCCCTCTCTTTCAATCATGCTTTGAGGATACAGTGAGATTGGTTACAGTGAACCTTCAATGAGTAGAATGTGGTATGCCATGGTGGGTT
GTAGTAGATGGTGCTCCCTGCCTTTTCTCCTCTGTTTTCCTCAATTTGGGAACAAATGAGATTGGCAGAAGGAGGGAGCTCACGGTGCAG
TACTTTTCTACCAAAGTGTGCCCACTGGTGTCACCTCCTAATGTTAACTTGGATTTCCTAAAGCAGTCCCACTCTGTTATGAGAGTCACT
GACTCCCGTGGACATCCCCACAGTAAGCAGCCTTACAAAATCCAGTCCCCTTAGGGCAGAGTGAGTGTCATAGAATAATGACTCCAAACC
CACGTCAAAAATGGCTTGTTTTCAGCGATGTTATAAAACAAAGGCCTGTTTTTTGGAATTGGGGGTGACTGGGTGGTTTGGATTGAAATG
TGGACAAAGATAGCATGTGTATTTTGAATAAAATAAAAATTTTGTAATAAAACTTTTAAAAATCAGTGATGTAAAATCAATATTTAAGAC
TATAGGCTATAAATTGTTTGATTTCATTAACTAGCCCTTTTGATGCCTAGACATGTTGTAAAAAAATTGTGCTATGGCTGCCTTTTCTTC
TGCCCCACAACACAAAGGGCTATTTCTACAAGGCAAAGTTTTGTATATGTGCTATTCTTTACTTCAGATTGAGAGTTGGGAAAAACTGGA
GTAAATAATGGGTTTCTTACTTGCTTAAAAGCATATTTATATGTGTATCTCAATATATACAAGGCAGGTTCCCCTATAAAAGTCTGGAAT
GTACTGCTTAATTTTACACTTGTGTAGACACGATTATTTGTGACTGAAAAGTGGAATAACGTGTGGATTTTGTCAACTCATTATCAGTCT
GTTAGCAGTCCTCTATGTGAGGCATGGTGGTCTAATTGTGAAATTCTCCCTGTATATGGGTGTCTGTGTGAAAGACAGCACTTTCTTCCT
GTAAATATCTTTTGATATCCATTTATGTAGAATTCCAATGAATATGTCTTTGGAAAAGGTAATGTATCAAAGTTTTTATTTTGCCAATTG
ATCTAAATGCCCATATAACTAATCAGAAATCCAGTTTGGTTCAGATTGGGATTTTCTTTTAAAGAAAAAAAAAGTATGCAGAAAAGACTA
TTGGAAGAATCATGTGTTAGTGACACTTTACATCAACGTTGCTTCAATATTTTGGAATTGACCAGGCTGCTTTCTCCTACCTGCAAGAGA
ATGTGCCTGACATTTCCCAGTGCTTACTTTGGGCTATAGGAAGTCCAGCGGGGATAGCTCGAGCCTCTTGCTCCCTGAGTCATTTATTCC
CTTTACCTGAACAGAGCCTTACCTGCAATTCATAGTGAGAGCACCTGGGTCTGTATCCTGACTCCACTCTAAGTGAGGTGGGACTGAATC
ACTGTACCTCTCTGGGCCTTTTCATTTGAAACAAGTGGGTTAGACTAGATTAGCTCCAAAGTCCTCTCTTGCCCTAACATTTTATTTTTA
TTTTCCTGTGGTTACCACTAGGGTCTGACACGTAAAATGTGAGGGATCACTTAGAGGTTTGGATGTTATATTTTTGCATTGTTACAGCTT
ATACTCCCCAGTTGAGGACCTGTGTCATTCTTAGTGGCCCCACGACCCCTCTGTTTGTATTCCTGCTCCACTTATCTATACTTTTTTGGG
TAATCATCCCACTTTTTTTTTTTCTTGAGATGGAGTCTCGCTGTGTTGCCAAGGCTGGAGTACAGTGGTGCAATCTCAGCTCACTGCAGC
CTCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCTTCCCAAGTAGCTGGGATTACTGGCGCACGCCACTACGCCCAGCTAATTTTTGTA
TTTTTAGTAGAGACAGGGTTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCTTGACCTCAACCTGCCTCAGCCTCCCAAAGTGCTGGGAT
TACACGCATGAGCTACCGCGTCCAGCCCCACTTTTTTTCTACTCTTGAAAAAAACAACTTTCTAGTCCATGAGGTACTTTGGCTCCATCC
CCCTCAAAAACAAAACAAAAAATCCATTTAAAGTGTCCTCCTAGAAAAGCCTCAGAACTGCCTTCAACTACATCTGTCACCTTTATAGAA
TATTTTGAAATTCTGGAAGAGGATGGGAAACAAAATTCTAATTTAGCTAGAGCTGTGATCCCCAAATAAGTGCTGACAAAATTGTCTACC
ACAGAAAGGCCGTCCTTGTCATCTTGTAGGCATCACTGCTGCTAAATCACATCAGTACATGCCTTCTGTGGGGAGATGGCAGGGGGCAGG
GGCAGGACCAGGGGATGGGATTAGATAAAGTGTGATAATGTCCTTTAGATAAAAGAAATCCTACGCTATAGAACAAGGTTCTGTACTCTT
GAGTTGGTGTCTGAGATCACCTGCACAGTGTTACAGAGATTTTCCACTCCATAAATCACTCTAAAAGAGTTTGCATAAGACTCGGTAGAC
CTGTGCTATTCAATGTGGCAGTCAACAGCCATATGTGGCGATGACTACTCAAAGTTTGGCTTGTTCAAATCGAGACTGTGTTGTACACAT
ACAATACACACCAGATTTTGAAGGCTTGGTACCAAAAAGGAATTTAAAATATTTCACCAATATTTCATATTGATAACATGCTGAAATGAC
ACTATTTTGGATGTACTAAGTAAAATATTAACAATTTAATATATTTATATAATTGAAATTAAAATTCTTTTCACCCATTTTTATTTTTTT
AAAAATGTGGCCCCTAAAGAACTTCAAATTAGACATGTGGATAACGTTATACTTCTATTGGACAGCCCCACTCTAGACTTACATGGTGTG
GGGTAGGCAGTGAAATCCGTAAATAGGAAACGCAATTCTGCAAAGTATCTAAATAGACAGAAACAACACAAATATTTTTGCTGGAGTCAG
GAGCACTGTGAGGCACAGAACATCTCCCAGAAAGCAGATTTTTTTTTTCTGCCGAAAAACCAATATATATATGTATGATCCCAATTAAAA
GACAAAAGCAAATGAGCCCCAAACTGCCTGTCTTCAGCTTTGCCTGGGAGCTGCTACCTTTGCTCTTCTAGCATCTTCTAGGTACCAAGG
ATATTAGCCACTTGAGGGTGTTGGGCATATTTGTTTCATTGTAGGCAAAATCCTCTTGTGGTTTCCCCTCCCCAGGTATTGTTGAGTCTG
TTCAAAGCTGGGTGTGTTGAAACACTGCACAAATCCTGCCACTCTTGATGTGCCGCTTGTCTCAGCCTTGGCAGAGGCTGAGTCTGTTCC
TGTGCCCACCTGTCCAGCAGGTTTTGATGTTGGCTCCTGAAAGAGTTTGTATTTATTTTATTTTGCACTAGTCACAGTTGTTGTTAAACT
GTATCAAATGTTTTGGGAGATTATTTGCCTGAGATGGAAAGAGAGATGGATGATTTATTGCTTCAATTGTTTTAAATTAAAAGCTATTCT
CACAA

>89581_89581_2_TBL1Y-USP13_TBL1Y_chrY_6942661_ENST00000355162_USP13_chr3_179478899_ENST00000263966_length(amino acids)=532AA_BP=318
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYVEAEISINKDGTVFDSRPIESLSLIVAVIPD
VVQMRQQAFGEKLTQQQASAAATEASAMAKAATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHES
EVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLAS
TLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSASDIDESSVMQLAEMGFPLEACRKAVYFTGNMGAEVAFNWII
VHMEEPDFAEPLTMPGYGGAASAGASVFGASGLDNQPPEEIVAIITSMGFQRNQAIQALRATNNNLERALDWIFSHPEFEEDSDFVIEME
NNANANIISEAKPEGPRVKDGSGTYELFAFISHMGTSTMSGHYICHIKKEGRWVIYNDHKVCASERPPKDLGYMYFYRRIPS

--------------------------------------------------------------
>89581_89581_3_TBL1Y-USP13_TBL1Y_chrY_6942661_ENST00000383032_USP13_chr3_179478899_ENST00000263966_length(transcript)=7506nt_BP=1602nt
CCAGTGCCCCCAATTCGCGCTCGGGAGTGAGGAGCCGCCAACACCCCAGCTCCGCTGCTGCCGCCACCGCAGTGCTCTCTAGTCGCCATT
GGTTACCTAAACTTTCCAGTACCCGCGACCTTTCCGGGACTCCGCGGCGGCGGGGCAGAGGCGGCCCAGGGGCGGCACGCGGCTGCTCCG
GTGCGCCGGGCTCTTTTCGGCCGCCGCACGGCCGGGCCTCACAGGCTGCCCTCCTGAGAGAGGCTCAGAACACGGCCAGGTACGCGCCGC
CGCCACAGTTGCGCTGCTAGCGACGAGGTGTTTTCCTCTGCTGGCACGCCAGAATCCCTGGTTCAGCCTGGAAGGCGAGGGGCAGGACTC
CCCAGACAGTGGCCTCAGTGTGGCATTGATGTCCTAGGTTGTAAGGTGCTAAGGGGAATGCCAGCTGTTCTCTTAACAGAAGGGCAGTTT
TTGAAGAAATGAAGCAGGACTTGATGTGGATTGTCATAAACTGTTTCTCCCTAAAGAGGCTGGTCCCCACAGACGGCTTGCCATTTCTAT
GACTGGATGCTGAGAAGCCTGCTGGTTCAGAGGTCCACACATGAAGTTACCATAAAGAGGGTGGTTCCAACTTCATCAATACCTCATCGC
CATGAGGTGAGGCTAAGATGAGCATAACCAGTGACGAGGTGAACTTTCTGGTTTATCGGTATCTCCAGGAGTCAGGTTTTTCTCACTCGG
CTTTCACGTTTGGGATCGAGAGCCACATCAGCCAGTCCAACATCAATGGGACACTAGTGCCACCGTCTGCCCTCATCTCCATTCTCCAGA
AGGGACTGCAGTATGTAGAGGCTGAGATAAGCATCAACAAGGATGGCACAGTGTTCGACAGCCGCCCTATAGAGTCCCTGTCCCTGATAG
TTGCTGTGATTCCTGATGTGGTGCAGATGCGGCAGCAGGCATTTGGAGAGAAGCTCACTCAGCAGCAAGCCAGTGCAGCAGCCACAGAGG
CATCAGCAATGGCAAAGGCGGCAACCATGACCCCAGCTGCTATTTCCCAGCAAAATCCTCCAAAGAACCGAGAGGCCACAGTGAACGGGG
AAGAGAATGGAGCACATGAAATCAATAATCACTCAAAGCCAATGGAAATAGATGGGGATGTTGAGATTCCACCCAACAAAGCCACAGTCC
TTCGGGGCCACGAGTCTGAGGTGTTCATTTGTGCCTGGAACCCTGTCAGTGATTTGCTAGCCTCTGGATCTGGAGACTCAACTGCAAGGA
TATGGAACCTGAATGAGAATAGCAACGGGGGCTCCACCCAGCTCGTGTTGAGACATTGTATACGAGAAGGGGGGCACGACGTCCCAAGTA
ATAAAGATGTCACCTCACTGGACTGGAACAGTGATGGAACACTATTGGCTATGGGTTCATATGATGGTTTCGCAAGAATATGGACAGAAA
ATGGTAACCTGGCCAGCACCTTAGGCCAACATAAAGGCCCCATCTTCGCTCTGAAATGGAACAAAAAGGGGAATTATGTTTTGAGTGCTG
GTGTAGACAAAACAACAATAATTTGGGATGCTCACACAGGAGAAGCCAAACAGCAGTTTCCTTTTCATTCAGCATCAGACATCGATGAGT
CATCAGTGATGCAGCTGGCCGAGATGGGTTTCCCGCTGGAAGCATGTCGCAAGGCTGTGTACTTCACTGGAAATATGGGCGCCGAGGTGG
CCTTCAACTGGATCATTGTTCACATGGAAGAGCCAGATTTTGCTGAGCCGCTGACCATGCCTGGTTATGGAGGGGCAGCTTCTGCTGGAG
CCTCTGTTTTTGGTGCTTCTGGACTGGATAACCAACCTCCAGAGGAAATCGTAGCTATCATCACCTCCATGGGATTTCAGCGAAATCAGG
CTATTCAGGCACTACGAGCAACGAATAATAACCTGGAAAGAGCACTGGATTGGATCTTTAGCCACCCTGAGTTTGAAGAAGACAGTGATT
TTGTGATTGAGATGGAGAATAATGCCAATGCAAACATTATTTCTGAGGCCAAGCCCGAAGGACCTAGAGTCAAGGATGGATCTGGAACAT
ATGAGCTATTTGCATTCATCAGTCACATGGGAACATCCACAATGAGTGGTCATTACATTTGCCATATCAAAAAGGAAGGAAGATGGGTGA
TTTACAATGACCACAAAGTTTGTGCCTCAGAAAGGCCCCCTAAAGACCTGGGCTACATGTACTTTTACCGCAGGATACCAAGCTAAACCT
CAAATATAAAAATTGGCGAAAAGAAGCCATACGCCTTTTTAATTTGCCAAAAAAAAAAAGAAGAAGAAGAAGTTGAAACAACTAGACATG
AAGGAATATATGGGGTATTTATCGTTTATTTAAAGAGCACGATCAGTTGACACCTTCTGAAATAGAACTGAGAAGAAATTTCTATTAGTG
ATGATACACTATTATATTGTAGATAGTTTTTATAAATGTTCAAAAAGATGATGATATTTAAAAACAAAAAAAGTATTCATATTGCTGGTG
GAGGATCTGCCATCAGCACATCAAAAATGGGGATGTGCCCCCAGCCCTCTATTTTGCTTTGGGGGTCAGTGATAGTGGCCTCTGGAGAAA
CCAAATAATGTGGCCAGTGGTGTGGCCTTACCCACAACAAATGAAAAGCCCACTTGTGTTTCATATAGAAAATCAGCAGTTGGGTGGGGC
TTTATTTGTGACATAATTTTTTTCATGACATACAATAATTTCTGATGTATCCATGTAGATATTATGCTCTGTCCATAATAGAGCCTCTGC
AATGAAAGATATTTTTAATTTGTCACATTAAAATTCATAATACGATTGTGTGAATGTGTGTGAGACTGACTGAGAGTGTGAGACTTTTAC
TAGAAAAGTGAGTCCACTAGAAAATCTGTGACAAGTTGGTTTTTAAAGTCTGAACAGTTGATATTAAGCATATCTGAAAAAAGCAAGTAA
ATATTTTAACAAAACTATGACTCAGGAACCTTCGAGAAGATTAGTTCCCCACTTAGATTTTTAAGGAGTAAAAAGGGCTGAGTTATGCCT
TTAAGTGCTGTCAAGAATTCACTTGGGTTTGGGACATTTGCTGGTGTAATGCTAGATGCCCACAGCAGCATAATATTGTACTTTGTCAAA
GGTAGGTAAATTCTCTGTTTCTCAGCAGCCCTTTCCCCAAAAGGTATGGTGTTTATTTTTAGTAAAAATAGCTAATCTCTTTTTACCATC
TCACATGATAACTCTTTGGAGTCATGTCAAGTGCCCCAAATTTGTCTGTGATTTTCCCATCTCTGAGCTCTTTATCTGCCTCCGTTTCCT
TGTTTTTCTGGGGCCAGAGTCTCATCTCTGCCTTTTTTTGGTGTATCACCTTCTGACTTGCCTTCATTGCTTGTCTGATGTGACCAACAG
TGTGATCTTGGACACACTAAGGATTTTAGATGCAAAGAAACTTTATACAACATTATGAAAGACTATCCTTTCCATTTTGGTTATTTCAGC
ATTTTAGTTGCAACCTGGGATTAGATTAGAGTTTCCAACGTGATGAAAAGTGGAATGATAGCATTCTATAATTTCCATAATTTTCCTACT
GGTCCGTACCAAATTCTAGAGTCTCTGGAGTTGCTATTTCAGAGTATTTGGTCAAACGAAAAAGAATTTATTGCTGTCTGTTTAACATGT
ATTTGTTTGGTTGAAAGGATCTTTTTAGAAACTGTAGGAAAATAAACAGAACCAACCAGGTGAAACAAAGCACAGACATTGGGTTAGGAT
GTAGTGAGTTGTGAACAATCAGGATTCTGGGTGTGATGGGGGTCCCTGTCTCATAGGTGATCCTTTGGTGCCATGTGACCGAGAGACATG
GTGTCTAAGGCCCATGGCCTGGAGACCTGGGTGCTGCTCCTAGCTGACTGTGGACCTTGGGCAAGTCCTTCATCCGTCCTGTGCCTCACT
GTCCTCATCTGAACAATGGTATGATGACACCTGCCCTCTCTTTCAATCATGCTTTGAGGATACAGTGAGATTGGTTACAGTGAACCTTCA
ATGAGTAGAATGTGGTATGCCATGGTGGGTTGTAGTAGATGGTGCTCCCTGCCTTTTCTCCTCTGTTTTCCTCAATTTGGGAACAAATGA
GATTGGCAGAAGGAGGGAGCTCACGGTGCAGTACTTTTCTACCAAAGTGTGCCCACTGGTGTCACCTCCTAATGTTAACTTGGATTTCCT
AAAGCAGTCCCACTCTGTTATGAGAGTCACTGACTCCCGTGGACATCCCCACAGTAAGCAGCCTTACAAAATCCAGTCCCCTTAGGGCAG
AGTGAGTGTCATAGAATAATGACTCCAAACCCACGTCAAAAATGGCTTGTTTTCAGCGATGTTATAAAACAAAGGCCTGTTTTTTGGAAT
TGGGGGTGACTGGGTGGTTTGGATTGAAATGTGGACAAAGATAGCATGTGTATTTTGAATAAAATAAAAATTTTGTAATAAAACTTTTAA
AAATCAGTGATGTAAAATCAATATTTAAGACTATAGGCTATAAATTGTTTGATTTCATTAACTAGCCCTTTTGATGCCTAGACATGTTGT
AAAAAAATTGTGCTATGGCTGCCTTTTCTTCTGCCCCACAACACAAAGGGCTATTTCTACAAGGCAAAGTTTTGTATATGTGCTATTCTT
TACTTCAGATTGAGAGTTGGGAAAAACTGGAGTAAATAATGGGTTTCTTACTTGCTTAAAAGCATATTTATATGTGTATCTCAATATATA
CAAGGCAGGTTCCCCTATAAAAGTCTGGAATGTACTGCTTAATTTTACACTTGTGTAGACACGATTATTTGTGACTGAAAAGTGGAATAA
CGTGTGGATTTTGTCAACTCATTATCAGTCTGTTAGCAGTCCTCTATGTGAGGCATGGTGGTCTAATTGTGAAATTCTCCCTGTATATGG
GTGTCTGTGTGAAAGACAGCACTTTCTTCCTGTAAATATCTTTTGATATCCATTTATGTAGAATTCCAATGAATATGTCTTTGGAAAAGG
TAATGTATCAAAGTTTTTATTTTGCCAATTGATCTAAATGCCCATATAACTAATCAGAAATCCAGTTTGGTTCAGATTGGGATTTTCTTT
TAAAGAAAAAAAAAGTATGCAGAAAAGACTATTGGAAGAATCATGTGTTAGTGACACTTTACATCAACGTTGCTTCAATATTTTGGAATT
GACCAGGCTGCTTTCTCCTACCTGCAAGAGAATGTGCCTGACATTTCCCAGTGCTTACTTTGGGCTATAGGAAGTCCAGCGGGGATAGCT
CGAGCCTCTTGCTCCCTGAGTCATTTATTCCCTTTACCTGAACAGAGCCTTACCTGCAATTCATAGTGAGAGCACCTGGGTCTGTATCCT
GACTCCACTCTAAGTGAGGTGGGACTGAATCACTGTACCTCTCTGGGCCTTTTCATTTGAAACAAGTGGGTTAGACTAGATTAGCTCCAA
AGTCCTCTCTTGCCCTAACATTTTATTTTTATTTTCCTGTGGTTACCACTAGGGTCTGACACGTAAAATGTGAGGGATCACTTAGAGGTT
TGGATGTTATATTTTTGCATTGTTACAGCTTATACTCCCCAGTTGAGGACCTGTGTCATTCTTAGTGGCCCCACGACCCCTCTGTTTGTA
TTCCTGCTCCACTTATCTATACTTTTTTGGGTAATCATCCCACTTTTTTTTTTTCTTGAGATGGAGTCTCGCTGTGTTGCCAAGGCTGGA
GTACAGTGGTGCAATCTCAGCTCACTGCAGCCTCCTCCCGGGTTCAAGTGATTCTCCTGCCTCAGCTTCCCAAGTAGCTGGGATTACTGG
CGCACGCCACTACGCCCAGCTAATTTTTGTATTTTTAGTAGAGACAGGGTTTTGCCATGTTGGCCAGGCTGGTCTTGAACTCTTGACCTC
AACCTGCCTCAGCCTCCCAAAGTGCTGGGATTACACGCATGAGCTACCGCGTCCAGCCCCACTTTTTTTCTACTCTTGAAAAAAACAACT
TTCTAGTCCATGAGGTACTTTGGCTCCATCCCCCTCAAAAACAAAACAAAAAATCCATTTAAAGTGTCCTCCTAGAAAAGCCTCAGAACT
GCCTTCAACTACATCTGTCACCTTTATAGAATATTTTGAAATTCTGGAAGAGGATGGGAAACAAAATTCTAATTTAGCTAGAGCTGTGAT
CCCCAAATAAGTGCTGACAAAATTGTCTACCACAGAAAGGCCGTCCTTGTCATCTTGTAGGCATCACTGCTGCTAAATCACATCAGTACA
TGCCTTCTGTGGGGAGATGGCAGGGGGCAGGGGCAGGACCAGGGGATGGGATTAGATAAAGTGTGATAATGTCCTTTAGATAAAAGAAAT
CCTACGCTATAGAACAAGGTTCTGTACTCTTGAGTTGGTGTCTGAGATCACCTGCACAGTGTTACAGAGATTTTCCACTCCATAAATCAC
TCTAAAAGAGTTTGCATAAGACTCGGTAGACCTGTGCTATTCAATGTGGCAGTCAACAGCCATATGTGGCGATGACTACTCAAAGTTTGG
CTTGTTCAAATCGAGACTGTGTTGTACACATACAATACACACCAGATTTTGAAGGCTTGGTACCAAAAAGGAATTTAAAATATTTCACCA
ATATTTCATATTGATAACATGCTGAAATGACACTATTTTGGATGTACTAAGTAAAATATTAACAATTTAATATATTTATATAATTGAAAT
TAAAATTCTTTTCACCCATTTTTATTTTTTTAAAAATGTGGCCCCTAAAGAACTTCAAATTAGACATGTGGATAACGTTATACTTCTATT
GGACAGCCCCACTCTAGACTTACATGGTGTGGGGTAGGCAGTGAAATCCGTAAATAGGAAACGCAATTCTGCAAAGTATCTAAATAGACA
GAAACAACACAAATATTTTTGCTGGAGTCAGGAGCACTGTGAGGCACAGAACATCTCCCAGAAAGCAGATTTTTTTTTTCTGCCGAAAAA
CCAATATATATATGTATGATCCCAATTAAAAGACAAAAGCAAATGAGCCCCAAACTGCCTGTCTTCAGCTTTGCCTGGGAGCTGCTACCT
TTGCTCTTCTAGCATCTTCTAGGTACCAAGGATATTAGCCACTTGAGGGTGTTGGGCATATTTGTTTCATTGTAGGCAAAATCCTCTTGT
GGTTTCCCCTCCCCAGGTATTGTTGAGTCTGTTCAAAGCTGGGTGTGTTGAAACACTGCACAAATCCTGCCACTCTTGATGTGCCGCTTG
TCTCAGCCTTGGCAGAGGCTGAGTCTGTTCCTGTGCCCACCTGTCCAGCAGGTTTTGATGTTGGCTCCTGAAAGAGTTTGTATTTATTTT
ATTTTGCACTAGTCACAGTTGTTGTTAAACTGTATCAAATGTTTTGGGAGATTATTTGCCTGAGATGGAAAGAGAGATGGATGATTTATT
GCTTCAATTGTTTTAAATTAAAAGCTATTCTCACAA

>89581_89581_3_TBL1Y-USP13_TBL1Y_chrY_6942661_ENST00000383032_USP13_chr3_179478899_ENST00000263966_length(amino acids)=532AA_BP=318
MSITSDEVNFLVYRYLQESGFSHSAFTFGIESHISQSNINGTLVPPSALISILQKGLQYVEAEISINKDGTVFDSRPIESLSLIVAVIPD
VVQMRQQAFGEKLTQQQASAAATEASAMAKAATMTPAAISQQNPPKNREATVNGEENGAHEINNHSKPMEIDGDVEIPPNKATVLRGHES
EVFICAWNPVSDLLASGSGDSTARIWNLNENSNGGSTQLVLRHCIREGGHDVPSNKDVTSLDWNSDGTLLAMGSYDGFARIWTENGNLAS
TLGQHKGPIFALKWNKKGNYVLSAGVDKTTIIWDAHTGEAKQQFPFHSASDIDESSVMQLAEMGFPLEACRKAVYFTGNMGAEVAFNWII
VHMEEPDFAEPLTMPGYGGAASAGASVFGASGLDNQPPEEIVAIITSMGFQRNQAIQALRATNNNLERALDWIFSHPEFEEDSDFVIEME
NNANANIISEAKPEGPRVKDGSGTYELFAFISHMGTSTMSGHYICHIKKEGRWVIYNDHKVCASERPPKDLGYMYFYRRIPS

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Fusion Gene PPI Analysis for TBL1Y-USP13


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for TBL1Y-USP13


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for TBL1Y-USP13


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0037274Dermatologic disorders1CTD_human
TgeneC0274861Arsenic Poisoning, Inorganic1CTD_human
TgeneC0274862Nervous System, Organic Arsenic Poisoning1CTD_human
TgeneC0311375Arsenic Poisoning1CTD_human
TgeneC0751851Arsenic Encephalopathy1CTD_human
TgeneC0751852Arsenic Induced Polyneuropathy1CTD_human