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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ASH2L-MGME1 (FusionGDB2 ID:HG9070TG92667)

Fusion Gene Summary for ASH2L-MGME1

check button Fusion gene summary
Fusion gene informationFusion gene name: ASH2L-MGME1
Fusion gene ID: hg9070tg92667
HgeneTgene
Gene symbol

ASH2L

MGME1

Gene ID

9070

92667

Gene nameASH2 like, histone lysine methyltransferase complex subunitmitochondrial genome maintenance exonuclease 1
SynonymsASH2|ASH2L1|ASH2L2|Bre2C20orf72|DDK1|MTDPS11|bA504H3.4
Cytomap('ASH2L','ASH2L')('C20orf72','MGME1')

8p11.23

20p11.23

Type of geneprotein-codingprotein-coding
Descriptionset1/Ash2 histone methyltransferase complex subunit ASH2ASH2-like proteinash2 (absent, small, or homeotic)-likemitochondrial genome maintenance exonuclease 1
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000524263, ENST00000250635, 
ENST00000343823, ENST00000428278, 
ENST00000521652, ENST00000545394, 
Fusion gene scores* DoF score13 X 10 X 6=7806 X 5 X 4=120
# samples 147
** MAII scorelog2(14/780*10)=-2.47804729680464
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/120*10)=-0.777607578663552
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ASH2L [Title/Abstract] AND MGME1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointASH2L(37971805)-C20orf72(17968809), # samples:2
ASH2L(37971805)-MGME1(17968809), # samples:3
Anticipated loss of major functional domain due to fusion event.ASH2L-MGME1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASH2L-MGME1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ASH2L-MGME1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ASH2L-MGME1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ASH2L-MGME1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
ASH2L-MGME1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneASH2L

GO:0006974

cellular response to DNA damage stimulus

17500065

HgeneASH2L

GO:0043627

response to estrogen

16603732

HgeneASH2L

GO:0051568

histone H3-K4 methylation

17355966|19556245


check buttonFusion gene breakpoints across ASH2L (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across MGME1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E2-A15A-01AASH2Lchr8

37971805

-C20orf72chr20

17968809

+
ChimerDB4BRCATCGA-E2-A15A-06AASH2Lchr8

37971805

-C20orf72chr20

17968809

+
ChimerDB4BRCATCGA-E2-A15AASH2Lchr8

37971805

+C20orf72chr20

17968808

+
ChimerDB4BRCATCGA-E2-A15A-01AASH2Lchr8

37968351

+MGME1chr20

17968809

+
ChimerDB4BRCATCGA-E2-A15A-01AASH2Lchr8

37968351

+MGME1chr20

17970582

+
ChimerDB4BRCATCGA-E2-A15A-01AASH2Lchr8

37971805

+MGME1chr20

17968809

+
ChimerDB4BRCATCGA-E2-A15A-01AASH2Lchr8

37971805

+MGME1chr20

17970582

+
ChimerDB4BRCATCGA-E2-A15A-06AASH2Lchr8

37968351

+MGME1chr20

17970582

+
ChimerDB4BRCATCGA-E2-A15A-06AASH2Lchr8

37971805

+MGME1chr20

17968809

+
ChimerDB4BRCATCGA-E2-A15A-06AASH2Lchr8

37971805

+MGME1chr20

17970582

+


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Fusion Gene ORF analysis for ASH2L-MGME1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000524263ENST00000377704ASH2Lchr8

37968351

+MGME1chr20

17970582

+
3UTR-3CDSENST00000524263ENST00000377704ASH2Lchr8

37971805

+MGME1chr20

17970582

+
3UTR-3CDSENST00000524263ENST00000377709ASH2Lchr8

37968351

+MGME1chr20

17968809

+
3UTR-3CDSENST00000524263ENST00000377709ASH2Lchr8

37971805

+MGME1chr20

17968809

+
3UTR-3CDSENST00000524263ENST00000377709ASH2Lchr8

37968351

+MGME1chr20

17970582

+
3UTR-3CDSENST00000524263ENST00000377709ASH2Lchr8

37971805

+MGME1chr20

17970582

+
3UTR-3CDSENST00000524263ENST00000377710ASH2Lchr8

37968351

+MGME1chr20

17968809

+
3UTR-3CDSENST00000524263ENST00000377710ASH2Lchr8

37971805

+MGME1chr20

17968809

+
3UTR-3CDSENST00000524263ENST00000377710ASH2Lchr8

37968351

+MGME1chr20

17970582

+
3UTR-3CDSENST00000524263ENST00000377710ASH2Lchr8

37971805

+MGME1chr20

17970582

+
3UTR-3UTRENST00000524263ENST00000467391ASH2Lchr8

37968351

+MGME1chr20

17968809

+
3UTR-3UTRENST00000524263ENST00000467391ASH2Lchr8

37971805

+MGME1chr20

17968809

+
3UTR-3UTRENST00000524263ENST00000467391ASH2Lchr8

37968351

+MGME1chr20

17970582

+
3UTR-3UTRENST00000524263ENST00000467391ASH2Lchr8

37971805

+MGME1chr20

17970582

+
3UTR-intronENST00000524263ENST00000377704ASH2Lchr8

37968351

+MGME1chr20

17968809

+
3UTR-intronENST00000524263ENST00000377704ASH2Lchr8

37971805

+MGME1chr20

17968809

+
5CDS-3UTRENST00000250635ENST00000467391ASH2Lchr8

37968351

+MGME1chr20

17968809

+
5CDS-3UTRENST00000250635ENST00000467391ASH2Lchr8

37971805

+MGME1chr20

17968809

+
5CDS-3UTRENST00000250635ENST00000467391ASH2Lchr8

37968351

+MGME1chr20

17970582

+
5CDS-3UTRENST00000250635ENST00000467391ASH2Lchr8

37971805

+MGME1chr20

17970582

+
5CDS-3UTRENST00000343823ENST00000467391ASH2Lchr8

37968351

+MGME1chr20

17968809

+
5CDS-3UTRENST00000343823ENST00000467391ASH2Lchr8

37971805

+MGME1chr20

17968809

+
5CDS-3UTRENST00000343823ENST00000467391ASH2Lchr8

37968351

+MGME1chr20

17970582

+
5CDS-3UTRENST00000343823ENST00000467391ASH2Lchr8

37971805

+MGME1chr20

17970582

+
5CDS-3UTRENST00000428278ENST00000467391ASH2Lchr8

37968351

+MGME1chr20

17968809

+
5CDS-3UTRENST00000428278ENST00000467391ASH2Lchr8

37971805

+MGME1chr20

17968809

+
5CDS-3UTRENST00000428278ENST00000467391ASH2Lchr8

37968351

+MGME1chr20

17970582

+
5CDS-3UTRENST00000428278ENST00000467391ASH2Lchr8

37971805

+MGME1chr20

17970582

+
5CDS-3UTRENST00000521652ENST00000467391ASH2Lchr8

37968351

+MGME1chr20

17968809

+
5CDS-3UTRENST00000521652ENST00000467391ASH2Lchr8

37971805

+MGME1chr20

17968809

+
5CDS-3UTRENST00000521652ENST00000467391ASH2Lchr8

37968351

+MGME1chr20

17970582

+
5CDS-3UTRENST00000521652ENST00000467391ASH2Lchr8

37971805

+MGME1chr20

17970582

+
5CDS-3UTRENST00000545394ENST00000467391ASH2Lchr8

37968351

+MGME1chr20

17968809

+
5CDS-3UTRENST00000545394ENST00000467391ASH2Lchr8

37971805

+MGME1chr20

17968809

+
5CDS-3UTRENST00000545394ENST00000467391ASH2Lchr8

37968351

+MGME1chr20

17970582

+
5CDS-3UTRENST00000545394ENST00000467391ASH2Lchr8

37971805

+MGME1chr20

17970582

+
5CDS-intronENST00000250635ENST00000377704ASH2Lchr8

37968351

+MGME1chr20

17968809

+
5CDS-intronENST00000250635ENST00000377704ASH2Lchr8

37971805

+MGME1chr20

17968809

+
5CDS-intronENST00000343823ENST00000377704ASH2Lchr8

37968351

+MGME1chr20

17968809

+
5CDS-intronENST00000343823ENST00000377704ASH2Lchr8

37971805

+MGME1chr20

17968809

+
5CDS-intronENST00000428278ENST00000377704ASH2Lchr8

37968351

+MGME1chr20

17968809

+
5CDS-intronENST00000428278ENST00000377704ASH2Lchr8

37971805

+MGME1chr20

17968809

+
5CDS-intronENST00000521652ENST00000377704ASH2Lchr8

37968351

+MGME1chr20

17968809

+
5CDS-intronENST00000521652ENST00000377704ASH2Lchr8

37971805

+MGME1chr20

17968809

+
5CDS-intronENST00000545394ENST00000377704ASH2Lchr8

37968351

+MGME1chr20

17968809

+
5CDS-intronENST00000545394ENST00000377704ASH2Lchr8

37971805

+MGME1chr20

17968809

+
Frame-shiftENST00000250635ENST00000377709ASH2Lchr8

37968351

+MGME1chr20

17968809

+
Frame-shiftENST00000250635ENST00000377709ASH2Lchr8

37971805

+MGME1chr20

17968809

+
Frame-shiftENST00000250635ENST00000377709ASH2Lchr8

37968351

+MGME1chr20

17970582

+
Frame-shiftENST00000250635ENST00000377709ASH2Lchr8

37971805

+MGME1chr20

17970582

+
Frame-shiftENST00000250635ENST00000377710ASH2Lchr8

37968351

+MGME1chr20

17968809

+
Frame-shiftENST00000250635ENST00000377710ASH2Lchr8

37971805

+MGME1chr20

17968809

+
Frame-shiftENST00000250635ENST00000377710ASH2Lchr8

37968351

+MGME1chr20

17970582

+
Frame-shiftENST00000250635ENST00000377710ASH2Lchr8

37971805

+MGME1chr20

17970582

+
Frame-shiftENST00000343823ENST00000377709ASH2Lchr8

37968351

+MGME1chr20

17968809

+
Frame-shiftENST00000343823ENST00000377709ASH2Lchr8

37971805

+MGME1chr20

17968809

+
Frame-shiftENST00000343823ENST00000377709ASH2Lchr8

37968351

+MGME1chr20

17970582

+
Frame-shiftENST00000343823ENST00000377709ASH2Lchr8

37971805

+MGME1chr20

17970582

+
Frame-shiftENST00000343823ENST00000377710ASH2Lchr8

37968351

+MGME1chr20

17968809

+
Frame-shiftENST00000343823ENST00000377710ASH2Lchr8

37971805

+MGME1chr20

17968809

+
Frame-shiftENST00000343823ENST00000377710ASH2Lchr8

37968351

+MGME1chr20

17970582

+
Frame-shiftENST00000343823ENST00000377710ASH2Lchr8

37971805

+MGME1chr20

17970582

+
Frame-shiftENST00000428278ENST00000377709ASH2Lchr8

37968351

+MGME1chr20

17968809

+
Frame-shiftENST00000428278ENST00000377709ASH2Lchr8

37971805

+MGME1chr20

17968809

+
Frame-shiftENST00000428278ENST00000377709ASH2Lchr8

37968351

+MGME1chr20

17970582

+
Frame-shiftENST00000428278ENST00000377709ASH2Lchr8

37971805

+MGME1chr20

17970582

+
Frame-shiftENST00000428278ENST00000377710ASH2Lchr8

37968351

+MGME1chr20

17968809

+
Frame-shiftENST00000428278ENST00000377710ASH2Lchr8

37971805

+MGME1chr20

17968809

+
Frame-shiftENST00000428278ENST00000377710ASH2Lchr8

37968351

+MGME1chr20

17970582

+
Frame-shiftENST00000428278ENST00000377710ASH2Lchr8

37971805

+MGME1chr20

17970582

+
Frame-shiftENST00000521652ENST00000377709ASH2Lchr8

37968351

+MGME1chr20

17968809

+
Frame-shiftENST00000521652ENST00000377709ASH2Lchr8

37971805

+MGME1chr20

17968809

+
Frame-shiftENST00000521652ENST00000377709ASH2Lchr8

37968351

+MGME1chr20

17970582

+
Frame-shiftENST00000521652ENST00000377709ASH2Lchr8

37971805

+MGME1chr20

17970582

+
Frame-shiftENST00000521652ENST00000377710ASH2Lchr8

37968351

+MGME1chr20

17968809

+
Frame-shiftENST00000521652ENST00000377710ASH2Lchr8

37971805

+MGME1chr20

17968809

+
Frame-shiftENST00000521652ENST00000377710ASH2Lchr8

37968351

+MGME1chr20

17970582

+
Frame-shiftENST00000521652ENST00000377710ASH2Lchr8

37971805

+MGME1chr20

17970582

+
Frame-shiftENST00000545394ENST00000377709ASH2Lchr8

37968351

+MGME1chr20

17968809

+
Frame-shiftENST00000545394ENST00000377709ASH2Lchr8

37971805

+MGME1chr20

17968809

+
Frame-shiftENST00000545394ENST00000377709ASH2Lchr8

37968351

+MGME1chr20

17970582

+
Frame-shiftENST00000545394ENST00000377709ASH2Lchr8

37971805

+MGME1chr20

17970582

+
Frame-shiftENST00000545394ENST00000377710ASH2Lchr8

37968351

+MGME1chr20

17968809

+
Frame-shiftENST00000545394ENST00000377710ASH2Lchr8

37971805

+MGME1chr20

17968809

+
Frame-shiftENST00000545394ENST00000377710ASH2Lchr8

37968351

+MGME1chr20

17970582

+
Frame-shiftENST00000545394ENST00000377710ASH2Lchr8

37971805

+MGME1chr20

17970582

+
In-frameENST00000250635ENST00000377704ASH2Lchr8

37968351

+MGME1chr20

17970582

+
In-frameENST00000250635ENST00000377704ASH2Lchr8

37971805

+MGME1chr20

17970582

+
In-frameENST00000343823ENST00000377704ASH2Lchr8

37968351

+MGME1chr20

17970582

+
In-frameENST00000343823ENST00000377704ASH2Lchr8

37971805

+MGME1chr20

17970582

+
In-frameENST00000428278ENST00000377704ASH2Lchr8

37968351

+MGME1chr20

17970582

+
In-frameENST00000428278ENST00000377704ASH2Lchr8

37971805

+MGME1chr20

17970582

+
In-frameENST00000521652ENST00000377704ASH2Lchr8

37968351

+MGME1chr20

17970582

+
In-frameENST00000521652ENST00000377704ASH2Lchr8

37971805

+MGME1chr20

17970582

+
In-frameENST00000545394ENST00000377704ASH2Lchr8

37968351

+MGME1chr20

17970582

+
In-frameENST00000545394ENST00000377704ASH2Lchr8

37971805

+MGME1chr20

17970582

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000343823ASH2Lchr837968351+ENST00000377704MGME1chr2017970582+20788943091064251
ENST00000250635ASH2Lchr837968351+ENST00000377704MGME1chr2017970582+182764358813251
ENST00000545394ASH2Lchr837968351+ENST00000377704MGME1chr2017970582+16244401366121
ENST00000428278ASH2Lchr837968351+ENST00000377704MGME1chr2017970582+1928744357914185
ENST00000521652ASH2Lchr837968351+ENST00000377704MGME1chr2017970582+1782598211768185
ENST00000343823ASH2Lchr837971805+ENST00000377704MGME1chr2017970582+21749903091160283
ENST00000250635ASH2Lchr837971805+ENST00000377704MGME1chr2017970582+192373958909283
ENST00000545394ASH2Lchr837971805+ENST00000377704MGME1chr2017970582+1720536272706144
ENST00000428278ASH2Lchr837971805+ENST00000377704MGME1chr2017970582+20248403571010217
ENST00000521652ASH2Lchr837971805+ENST00000377704MGME1chr2017970582+1878694211864217

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000343823ENST00000377704ASH2Lchr837968351+MGME1chr2017970582+0.0047731990.99522674
ENST00000250635ENST00000377704ASH2Lchr837968351+MGME1chr2017970582+0.0041301940.9958698
ENST00000545394ENST00000377704ASH2Lchr837968351+MGME1chr2017970582+0.0104250070.98957497
ENST00000428278ENST00000377704ASH2Lchr837968351+MGME1chr2017970582+0.025954740.9740452
ENST00000521652ENST00000377704ASH2Lchr837968351+MGME1chr2017970582+0.0470970050.952903
ENST00000343823ENST00000377704ASH2Lchr837971805+MGME1chr2017970582+0.0016524840.9983475
ENST00000250635ENST00000377704ASH2Lchr837971805+MGME1chr2017970582+0.0017173020.9982827
ENST00000545394ENST00000377704ASH2Lchr837971805+MGME1chr2017970582+0.0150294580.98497057
ENST00000428278ENST00000377704ASH2Lchr837971805+MGME1chr2017970582+0.0103314830.98966855
ENST00000521652ENST00000377704ASH2Lchr837971805+MGME1chr2017970582+0.0093228630.9906771

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Fusion Genomic Features for ASH2L-MGME1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ASH2Lchr837971805+MGME1chr2017970581+0.0317855030.96821445
ASH2Lchr837968351+MGME1chr2017970581+0.0004681130.99953187
ASH2Lchr837971805+MGME1chr2017968808+4.03E-050.9999597
ASH2Lchr837971805+MGME1chr2017968808+4.03E-050.9999597
ASH2Lchr837968351+MGME1chr2017968808+4.01E-070.99999964
ASH2Lchr837971805+MGME1chr2017970581+0.0317855030.96821445
ASH2Lchr837968351+MGME1chr2017970581+0.0004681130.99953187
ASH2Lchr837971805+MGME1chr2017968808+4.03E-050.9999597
ASH2Lchr837971805+MGME1chr2017968808+4.03E-050.9999597
ASH2Lchr837968351+MGME1chr2017968808+4.01E-070.99999964

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ASH2L-MGME1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:37971805/chr20:17968809)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASH2Lchr8:37968351chr20:17970582ENST00000343823+51667_177195629.0RegionNote=DNA-binding
HgeneASH2Lchr8:37971805chr20:17970582ENST00000343823+61667_177227629.0RegionNote=DNA-binding
HgeneASH2Lchr8:37968351chr20:17970582ENST00000250635+5151_66101502.0Zinc fingerNote=PHD-type%3B atypical
HgeneASH2Lchr8:37968351chr20:17970582ENST00000343823+516117_150195629.0Zinc fingerNote=C4-type
HgeneASH2Lchr8:37968351chr20:17970582ENST00000343823+5161_66195629.0Zinc fingerNote=PHD-type%3B atypical
HgeneASH2Lchr8:37968351chr20:17970582ENST00000428278+5161_66101535.0Zinc fingerNote=PHD-type%3B atypical
HgeneASH2Lchr8:37968351chr20:17970582ENST00000521652+5151_66101502.0Zinc fingerNote=PHD-type%3B atypical
HgeneASH2Lchr8:37971805chr20:17970582ENST00000250635+6151_66133502.0Zinc fingerNote=PHD-type%3B atypical
HgeneASH2Lchr8:37971805chr20:17970582ENST00000343823+616117_150227629.0Zinc fingerNote=C4-type
HgeneASH2Lchr8:37971805chr20:17970582ENST00000343823+6161_66227629.0Zinc fingerNote=PHD-type%3B atypical
HgeneASH2Lchr8:37971805chr20:17970582ENST00000428278+6161_66133535.0Zinc fingerNote=PHD-type%3B atypical
HgeneASH2Lchr8:37971805chr20:17970582ENST00000521652+6151_66133502.0Zinc fingerNote=PHD-type%3B atypical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneASH2Lchr8:37968351chr20:17970582ENST00000250635+515360_583101502.0DomainB30.2/SPRY
HgeneASH2Lchr8:37968351chr20:17970582ENST00000343823+516360_583195629.0DomainB30.2/SPRY
HgeneASH2Lchr8:37968351chr20:17970582ENST00000428278+516360_583101535.0DomainB30.2/SPRY
HgeneASH2Lchr8:37968351chr20:17970582ENST00000521652+515360_583101502.0DomainB30.2/SPRY
HgeneASH2Lchr8:37971805chr20:17970582ENST00000250635+615360_583133502.0DomainB30.2/SPRY
HgeneASH2Lchr8:37971805chr20:17970582ENST00000343823+616360_583227629.0DomainB30.2/SPRY
HgeneASH2Lchr8:37971805chr20:17970582ENST00000428278+616360_583133535.0DomainB30.2/SPRY
HgeneASH2Lchr8:37971805chr20:17970582ENST00000521652+615360_583133502.0DomainB30.2/SPRY
HgeneASH2Lchr8:37968351chr20:17970582ENST00000250635+51567_177101502.0RegionNote=DNA-binding
HgeneASH2Lchr8:37968351chr20:17970582ENST00000428278+51667_177101535.0RegionNote=DNA-binding
HgeneASH2Lchr8:37968351chr20:17970582ENST00000521652+51567_177101502.0RegionNote=DNA-binding
HgeneASH2Lchr8:37971805chr20:17970582ENST00000250635+61567_177133502.0RegionNote=DNA-binding
HgeneASH2Lchr8:37971805chr20:17970582ENST00000428278+61667_177133535.0RegionNote=DNA-binding
HgeneASH2Lchr8:37971805chr20:17970582ENST00000521652+61567_177133502.0RegionNote=DNA-binding
HgeneASH2Lchr8:37968351chr20:17970582ENST00000250635+515117_150101502.0Zinc fingerNote=C4-type
HgeneASH2Lchr8:37968351chr20:17970582ENST00000428278+516117_150101535.0Zinc fingerNote=C4-type
HgeneASH2Lchr8:37968351chr20:17970582ENST00000521652+515117_150101502.0Zinc fingerNote=C4-type
HgeneASH2Lchr8:37971805chr20:17970582ENST00000250635+615117_150133502.0Zinc fingerNote=C4-type
HgeneASH2Lchr8:37971805chr20:17970582ENST00000428278+616117_150133535.0Zinc fingerNote=C4-type
HgeneASH2Lchr8:37971805chr20:17970582ENST00000521652+615117_150133502.0Zinc fingerNote=C4-type


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Fusion Gene Sequence for ASH2L-MGME1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>7131_7131_1_ASH2L-MGME1_ASH2L_chr8_37968351_ENST00000250635_MGME1_chr20_17970582_ENST00000377704_length(transcript)=1827nt_BP=643nt
CACAGCAACGCGCGCGAGAGAAGAGAGTATTCTCGCGAGAAGTCCAGGGGTGGCCGTGATGGCGGCGGCAGGAGCAGGACCTGGCCAGGA
AGCGGGTGCCGGGCCTGGCCCAGGAGCGGTCGCAAATGCAACAGGGGCAGAAGAGGGGGAGATGAAGCCGGTGGCAGCGGGAGCAGCCGC
TCCTCCTGGAGAGGGGATCTCTGCTGCTCCGACAGTTGAGCCCAGTTCCGGGGAGGCTGAAGGCGGGGAGGCAAACTTGGTCGATGTAAG
CGGTGGCTTGGAGACAGAATCATCTAATGGAAAAGATACACTAGAAGGTGCTGGGGATACATCAGAGGTGATGGATACTCAGGCGGGCTC
CGTGGATGAAGAGAATGGCCGACAGTTGGGTGAGGTAGAGCTGCAATGTGGGATTTGTACAAAATGGTTCACGGCTGACACATTTGGCAT
AGATACCTCATCCTGTCTACCTTTCATGACCAACTACAGTTTTCATTGCAACGTCTGCCATCACAGTGGGAATACCTATTTCCTCCGGAA
GCAAGCAAACTTGAAGGAAATGTGCCTTAGTGCTTTGGCCAACCTGACATGGCAGTCCCGAACACAGGATGAACATCCGAAGACAATGTT
CTCCAAAGATAAGGTTCAATGTGGCTTAATTGTGGTGGCCTACAAAGATGGATCACCTGCCCACCCACATTTCATGGATGCAGAGCTCTG
TTCCCAGTACTGGACCAAGTGGCTTCTTCGACTAGAAGAATATACGGAAAAGAAAAAGAACCAGAATATTCAGAAACCAGAATATTCAGA
ATAGGGAGCAAGTTGCTATTTGGGAACATTCAGCACCTTCTCACAGTTTGGGAACATATATTGCTGTTTACTCCAGTGTAAAAATGAGGT
GCCACTGGATCTGAGTGCTACACGAACACAAGTAGAAGTATTAATTTGTTGAAATGTGTTGTTACCAAAAAGACTGAAAAGCCCCAAAGT
CTAGATATAAAGACCTAGACTTCGGCACGCGAAATCCCAGCTATGCTACCTCTTATTTACCTGAAAGGAGGACACGCAGGATGGGCAGTC
ATGCTGGTGACTCTTGTACTCCCTTGAGGGACATTGGGGGGGGGGGGGCGTGGTCCCAGGCAGGATGCCCAGTCTTTGAGCTGAGATTGG
AAGGCAGTGAGGCTGAGGGTGCCAAGATTTCCCCAGGGTTCACCCAGAGGGGAAGGGGCTACATGCCCCCAGCTGTGTGCAGGGAGGACA
CATCAGCCCACTACCGCTGCCAACACCAATGCCTAAAACTTGTTTCATACATTGGGGTTTTCTATATATTTCAGCTGGGAAAAGCTTACA
TTTAACCTTTTGAAAAAATAAATACGTGATTAGCCTCAACTAAACATTGCTGACTATAAAGACAGTATATTCACCATGTCGCTGGCAATA
TGTCATTGCGTAACACCAAATAACCCCCCAGAAGTAGCCAGAGGCCAGTTTGAACATCACAATTCTAAGTGTTTTAGTAACTATTTCTGG
CGTGAGTCAACAGATCATGTAGATAGAGTCAATTATTGTTTGTGGAGTTTTTCAGCTATAGGGGAGGGGAACTATTAAAATCCATTTGTT
TCTATTCAATAGGTAATAAAAATTAGTTGTCCCTGGGTTTGGGAAACTTAAATGCCCATTACAGCCCTGGGGAAGGGTTTTCTGTCTTAT
GGAGTGAGTCTTAGCATTTAAGTTATACAGTTGCTGCCTTAAAATAGTAGCCTGCTACAATGACTTCTTTGGGTAGCCATTTTCATAAGA
AATAAAATACAAGATATGAGTAATGAA

>7131_7131_1_ASH2L-MGME1_ASH2L_chr8_37968351_ENST00000250635_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=251AA_BP=195
MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGD
TSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQS
RTQDEHPKTMFSKDKVQCGLIVVAYKDGSPAHPHFMDAELCSQYWTKWLLRLEEYTEKKKNQNIQKPEYSE

--------------------------------------------------------------
>7131_7131_2_ASH2L-MGME1_ASH2L_chr8_37968351_ENST00000343823_MGME1_chr20_17970582_ENST00000377704_length(transcript)=2078nt_BP=894nt
GCAGAATATCCAGTCGTAGCCACGAAAATACGCCGCGTCAGTCCCTGACTCGAAAGGAAGTCCTCCAGAGAGCCGCACTAACCATCTAGC
TTCCTCCACCTTCAGCCTGCCAGGCCCGCGGCCACCGCCGGCGCGGGAGGCCGGCCCACCTCTGCCCGCGCGCCTGGCCTTAAAGCGGTC
GTGGAATTATGCTTCCTCAGGCAGGCGGTGGACGCACCGCGGGCTTTTTCTGTTTGAAGACTACAGCGTCACACAGCAACGCGCGCGAGA
GAAGAGAGTATTCTCGCGAGAAGTCCAGGGGTGGCCGTGATGGCGGCGGCAGGAGCAGGACCTGGCCAGGAAGCGGGTGCCGGGCCTGGC
CCAGGAGCGGTCGCAAATGCAACAGGGGCAGAAGAGGGGGAGATGAAGCCGGTGGCAGCGGGAGCAGCCGCTCCTCCTGGAGAGGGGATC
TCTGCTGCTCCGACAGTTGAGCCCAGTTCCGGGGAGGCTGAAGGCGGGGAGGCAAACTTGGTCGATGTAAGCGGTGGCTTGGAGACAGAA
TCATCTAATGGAAAAGATACACTAGAAGGTGCTGGGGATACATCAGAGGTGATGGATACTCAGGCGGGCTCCGTGGATGAAGAGAATGGC
CGACAGTTGGGTGAGGTAGAGCTGCAATGTGGGATTTGTACAAAATGGTTCACGGCTGACACATTTGGCATAGATACCTCATCCTGTCTA
CCTTTCATGACCAACTACAGTTTTCATTGCAACGTCTGCCATCACAGTGGGAATACCTATTTCCTCCGGAAGCAAGCAAACTTGAAGGAA
ATGTGCCTTAGTGCTTTGGCCAACCTGACATGGCAGTCCCGAACACAGGATGAACATCCGAAGACAATGTTCTCCAAAGATAAGGTTCAA
TGTGGCTTAATTGTGGTGGCCTACAAAGATGGATCACCTGCCCACCCACATTTCATGGATGCAGAGCTCTGTTCCCAGTACTGGACCAAG
TGGCTTCTTCGACTAGAAGAATATACGGAAAAGAAAAAGAACCAGAATATTCAGAAACCAGAATATTCAGAATAGGGAGCAAGTTGCTAT
TTGGGAACATTCAGCACCTTCTCACAGTTTGGGAACATATATTGCTGTTTACTCCAGTGTAAAAATGAGGTGCCACTGGATCTGAGTGCT
ACACGAACACAAGTAGAAGTATTAATTTGTTGAAATGTGTTGTTACCAAAAAGACTGAAAAGCCCCAAAGTCTAGATATAAAGACCTAGA
CTTCGGCACGCGAAATCCCAGCTATGCTACCTCTTATTTACCTGAAAGGAGGACACGCAGGATGGGCAGTCATGCTGGTGACTCTTGTAC
TCCCTTGAGGGACATTGGGGGGGGGGGGGCGTGGTCCCAGGCAGGATGCCCAGTCTTTGAGCTGAGATTGGAAGGCAGTGAGGCTGAGGG
TGCCAAGATTTCCCCAGGGTTCACCCAGAGGGGAAGGGGCTACATGCCCCCAGCTGTGTGCAGGGAGGACACATCAGCCCACTACCGCTG
CCAACACCAATGCCTAAAACTTGTTTCATACATTGGGGTTTTCTATATATTTCAGCTGGGAAAAGCTTACATTTAACCTTTTGAAAAAAT
AAATACGTGATTAGCCTCAACTAAACATTGCTGACTATAAAGACAGTATATTCACCATGTCGCTGGCAATATGTCATTGCGTAACACCAA
ATAACCCCCCAGAAGTAGCCAGAGGCCAGTTTGAACATCACAATTCTAAGTGTTTTAGTAACTATTTCTGGCGTGAGTCAACAGATCATG
TAGATAGAGTCAATTATTGTTTGTGGAGTTTTTCAGCTATAGGGGAGGGGAACTATTAAAATCCATTTGTTTCTATTCAATAGGTAATAA
AAATTAGTTGTCCCTGGGTTTGGGAAACTTAAATGCCCATTACAGCCCTGGGGAAGGGTTTTCTGTCTTATGGAGTGAGTCTTAGCATTT
AAGTTATACAGTTGCTGCCTTAAAATAGTAGCCTGCTACAATGACTTCTTTGGGTAGCCATTTTCATAAGAAATAAAATACAAGATATGA
GTAATGAA

>7131_7131_2_ASH2L-MGME1_ASH2L_chr8_37968351_ENST00000343823_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=251AA_BP=195
MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGD
TSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQS
RTQDEHPKTMFSKDKVQCGLIVVAYKDGSPAHPHFMDAELCSQYWTKWLLRLEEYTEKKKNQNIQKPEYSE

--------------------------------------------------------------
>7131_7131_3_ASH2L-MGME1_ASH2L_chr8_37968351_ENST00000428278_MGME1_chr20_17970582_ENST00000377704_length(transcript)=1928nt_BP=744nt
ATCCCGCGGCTCCTGGAGCCCTGCCGCCCGCCCCCTGCGAACCCAGGCCCCGCCGCCAATGGCTCGCCCTGCCTCTGCGCCGCTTGGCCC
GTCCCCTCTCAAGCATATCTCGGATAACGCCCCTTCCGCACCTTTCACGGGCGGTGGGAGCTGAGGCTCCTGTCGTTATCTCTGATCCTT
GCACCCTGGCAGGAAGCTGGTAGCTCACACTTTAACGGGAGGCCTTCACATATTCCAGAAAAGAAACCACTTTGCAGTGCCAGACTGGAA
GAAGTAACGGTCACTCTGAAAACAGGGTGGGAGAGCTGCCTCTCTTTGAACCTCTCCCAGGACCAACTCTAACCCAGGGAGGCAAACTTG
GTCGATGTAAGCGGTGGCTTGGAGACAGAATCATCTAATGGAAAAGATACACTAGAAGGTGCTGGGGATACATCAGAGGTGATGGATACT
CAGGCGGGCTCCGTGGATGAAGAGAATGGCCGACAGTTGGGTGAGGTAGAGCTGCAATGTGGGATTTGTACAAAATGGTTCACGGCTGAC
ACATTTGGCATAGATACCTCATCCTGTCTACCTTTCATGACCAACTACAGTTTTCATTGCAACGTCTGCCATCACAGTGGGAATACCTAT
TTCCTCCGGAAGCAAGCAAACTTGAAGGAAATGTGCCTTAGTGCTTTGGCCAACCTGACATGGCAGTCCCGAACACAGGATGAACATCCG
AAGACAATGTTCTCCAAAGATAAGGTTCAATGTGGCTTAATTGTGGTGGCCTACAAAGATGGATCACCTGCCCACCCACATTTCATGGAT
GCAGAGCTCTGTTCCCAGTACTGGACCAAGTGGCTTCTTCGACTAGAAGAATATACGGAAAAGAAAAAGAACCAGAATATTCAGAAACCA
GAATATTCAGAATAGGGAGCAAGTTGCTATTTGGGAACATTCAGCACCTTCTCACAGTTTGGGAACATATATTGCTGTTTACTCCAGTGT
AAAAATGAGGTGCCACTGGATCTGAGTGCTACACGAACACAAGTAGAAGTATTAATTTGTTGAAATGTGTTGTTACCAAAAAGACTGAAA
AGCCCCAAAGTCTAGATATAAAGACCTAGACTTCGGCACGCGAAATCCCAGCTATGCTACCTCTTATTTACCTGAAAGGAGGACACGCAG
GATGGGCAGTCATGCTGGTGACTCTTGTACTCCCTTGAGGGACATTGGGGGGGGGGGGGCGTGGTCCCAGGCAGGATGCCCAGTCTTTGA
GCTGAGATTGGAAGGCAGTGAGGCTGAGGGTGCCAAGATTTCCCCAGGGTTCACCCAGAGGGGAAGGGGCTACATGCCCCCAGCTGTGTG
CAGGGAGGACACATCAGCCCACTACCGCTGCCAACACCAATGCCTAAAACTTGTTTCATACATTGGGGTTTTCTATATATTTCAGCTGGG
AAAAGCTTACATTTAACCTTTTGAAAAAATAAATACGTGATTAGCCTCAACTAAACATTGCTGACTATAAAGACAGTATATTCACCATGT
CGCTGGCAATATGTCATTGCGTAACACCAAATAACCCCCCAGAAGTAGCCAGAGGCCAGTTTGAACATCACAATTCTAAGTGTTTTAGTA
ACTATTTCTGGCGTGAGTCAACAGATCATGTAGATAGAGTCAATTATTGTTTGTGGAGTTTTTCAGCTATAGGGGAGGGGAACTATTAAA
ATCCATTTGTTTCTATTCAATAGGTAATAAAAATTAGTTGTCCCTGGGTTTGGGAAACTTAAATGCCCATTACAGCCCTGGGGAAGGGTT
TTCTGTCTTATGGAGTGAGTCTTAGCATTTAAGTTATACAGTTGCTGCCTTAAAATAGTAGCCTGCTACAATGACTTCTTTGGGTAGCCA
TTTTCATAAGAAATAAAATACAAGATATGAGTAATGAA

>7131_7131_3_ASH2L-MGME1_ASH2L_chr8_37968351_ENST00000428278_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=185AA_BP=129
MVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNT
YFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKVQCGLIVVAYKDGSPAHPHFMDAELCSQYWTKWLLRLEEYTEKKKNQNIQK
PEYSE

--------------------------------------------------------------
>7131_7131_4_ASH2L-MGME1_ASH2L_chr8_37968351_ENST00000521652_MGME1_chr20_17970582_ENST00000377704_length(transcript)=1782nt_BP=598nt
GGAGCTGAGGCTCCTGTCGTTATCTCTGATCCTTGCACCCTGGCAGGAAGCTGGTAGCTCACACTTTAACGGGAGGCCTTCACATATTCC
AGAAAAGAAACCACTTTGCAGTGCCAGACTGGAAGAAGTAACGGTCACTCTGAAAACAGGGTGGGAGAGCTGCCTCTCTTTGAACCTCTC
CCAGGACCAACTCTAACCCAGGGAGGCAAACTTGGTCGATGTAAGCGGTGGCTTGGAGACAGAATCATCTAATGGAAAAGATACACTAGA
AGGTGCTGGGGATACATCAGAGGTGATGGATACTCAGGCGGGCTCCGTGGATGAAGAGAATGGCCGACAGTTGGGTGAGGTAGAGCTGCA
ATGTGGGATTTGTACAAAATGGTTCACGGCTGACACATTTGGCATAGATACCTCATCCTGTCTACCTTTCATGACCAACTACAGTTTTCA
TTGCAACGTCTGCCATCACAGTGGGAATACCTATTTCCTCCGGAAGCAAGCAAACTTGAAGGAAATGTGCCTTAGTGCTTTGGCCAACCT
GACATGGCAGTCCCGAACACAGGATGAACATCCGAAGACAATGTTCTCCAAAGATAAGGTTCAATGTGGCTTAATTGTGGTGGCCTACAA
AGATGGATCACCTGCCCACCCACATTTCATGGATGCAGAGCTCTGTTCCCAGTACTGGACCAAGTGGCTTCTTCGACTAGAAGAATATAC
GGAAAAGAAAAAGAACCAGAATATTCAGAAACCAGAATATTCAGAATAGGGAGCAAGTTGCTATTTGGGAACATTCAGCACCTTCTCACA
GTTTGGGAACATATATTGCTGTTTACTCCAGTGTAAAAATGAGGTGCCACTGGATCTGAGTGCTACACGAACACAAGTAGAAGTATTAAT
TTGTTGAAATGTGTTGTTACCAAAAAGACTGAAAAGCCCCAAAGTCTAGATATAAAGACCTAGACTTCGGCACGCGAAATCCCAGCTATG
CTACCTCTTATTTACCTGAAAGGAGGACACGCAGGATGGGCAGTCATGCTGGTGACTCTTGTACTCCCTTGAGGGACATTGGGGGGGGGG
GGGCGTGGTCCCAGGCAGGATGCCCAGTCTTTGAGCTGAGATTGGAAGGCAGTGAGGCTGAGGGTGCCAAGATTTCCCCAGGGTTCACCC
AGAGGGGAAGGGGCTACATGCCCCCAGCTGTGTGCAGGGAGGACACATCAGCCCACTACCGCTGCCAACACCAATGCCTAAAACTTGTTT
CATACATTGGGGTTTTCTATATATTTCAGCTGGGAAAAGCTTACATTTAACCTTTTGAAAAAATAAATACGTGATTAGCCTCAACTAAAC
ATTGCTGACTATAAAGACAGTATATTCACCATGTCGCTGGCAATATGTCATTGCGTAACACCAAATAACCCCCCAGAAGTAGCCAGAGGC
CAGTTTGAACATCACAATTCTAAGTGTTTTAGTAACTATTTCTGGCGTGAGTCAACAGATCATGTAGATAGAGTCAATTATTGTTTGTGG
AGTTTTTCAGCTATAGGGGAGGGGAACTATTAAAATCCATTTGTTTCTATTCAATAGGTAATAAAAATTAGTTGTCCCTGGGTTTGGGAA
ACTTAAATGCCCATTACAGCCCTGGGGAAGGGTTTTCTGTCTTATGGAGTGAGTCTTAGCATTTAAGTTATACAGTTGCTGCCTTAAAAT
AGTAGCCTGCTACAATGACTTCTTTGGGTAGCCATTTTCATAAGAAATAAAATACAAGATATGAGTAATGAA

>7131_7131_4_ASH2L-MGME1_ASH2L_chr8_37968351_ENST00000521652_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=185AA_BP=129
MVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNT
YFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKVQCGLIVVAYKDGSPAHPHFMDAELCSQYWTKWLLRLEEYTEKKKNQNIQK
PEYSE

--------------------------------------------------------------
>7131_7131_5_ASH2L-MGME1_ASH2L_chr8_37968351_ENST00000545394_MGME1_chr20_17970582_ENST00000377704_length(transcript)=1624nt_BP=440nt
GATGGCGGCGGCAGGAGCAGGACCTGGCCAGGAAGCGGGTGCCGGGCCTGGCCCAGGAGCGGTCGCAAATGCAACAGGGGCAGAAGAGGG
GGAGATGAAGCCGGTGGCAGCGGGAGCAGCCGCTCCTCCTGGAGAGGGGATCTCTGCTGCTCCGACAGTTGAGCCCAGTTCCGGGGAGGC
TGAAGGCGGGGAGGCAAACTTGGTCGATGTAAGCGGTGGCTTGGAGACAGAATCATCTAATGGAAAAGATACACTAATCCTGTCTACCTT
TCATGACCAACTACAGTTTTCATTGCAACGTCTGCCATCACAGTGGGAATACCTATTTCCTCCGGAAGCAAGCAAACTTGAAGGAAATGT
GCCTTAGTGCTTTGGCCAACCTGACATGGCAGTCCCGAACACAGGATGAACATCCGAAGACAATGTTCTCCAAAGATAAGGTTCAATGTG
GCTTAATTGTGGTGGCCTACAAAGATGGATCACCTGCCCACCCACATTTCATGGATGCAGAGCTCTGTTCCCAGTACTGGACCAAGTGGC
TTCTTCGACTAGAAGAATATACGGAAAAGAAAAAGAACCAGAATATTCAGAAACCAGAATATTCAGAATAGGGAGCAAGTTGCTATTTGG
GAACATTCAGCACCTTCTCACAGTTTGGGAACATATATTGCTGTTTACTCCAGTGTAAAAATGAGGTGCCACTGGATCTGAGTGCTACAC
GAACACAAGTAGAAGTATTAATTTGTTGAAATGTGTTGTTACCAAAAAGACTGAAAAGCCCCAAAGTCTAGATATAAAGACCTAGACTTC
GGCACGCGAAATCCCAGCTATGCTACCTCTTATTTACCTGAAAGGAGGACACGCAGGATGGGCAGTCATGCTGGTGACTCTTGTACTCCC
TTGAGGGACATTGGGGGGGGGGGGGCGTGGTCCCAGGCAGGATGCCCAGTCTTTGAGCTGAGATTGGAAGGCAGTGAGGCTGAGGGTGCC
AAGATTTCCCCAGGGTTCACCCAGAGGGGAAGGGGCTACATGCCCCCAGCTGTGTGCAGGGAGGACACATCAGCCCACTACCGCTGCCAA
CACCAATGCCTAAAACTTGTTTCATACATTGGGGTTTTCTATATATTTCAGCTGGGAAAAGCTTACATTTAACCTTTTGAAAAAATAAAT
ACGTGATTAGCCTCAACTAAACATTGCTGACTATAAAGACAGTATATTCACCATGTCGCTGGCAATATGTCATTGCGTAACACCAAATAA
CCCCCCAGAAGTAGCCAGAGGCCAGTTTGAACATCACAATTCTAAGTGTTTTAGTAACTATTTCTGGCGTGAGTCAACAGATCATGTAGA
TAGAGTCAATTATTGTTTGTGGAGTTTTTCAGCTATAGGGGAGGGGAACTATTAAAATCCATTTGTTTCTATTCAATAGGTAATAAAAAT
TAGTTGTCCCTGGGTTTGGGAAACTTAAATGCCCATTACAGCCCTGGGGAAGGGTTTTCTGTCTTATGGAGTGAGTCTTAGCATTTAAGT
TATACAGTTGCTGCCTTAAAATAGTAGCCTGCTACAATGACTTCTTTGGGTAGCCATTTTCATAAGAAATAAAATACAAGATATGAGTAA
TGAA

>7131_7131_5_ASH2L-MGME1_ASH2L_chr8_37968351_ENST00000545394_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=121AA_BP=
MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLILSTF
HDQLQFSLQRLPSQWEYLFPPEASKLEGNVP

--------------------------------------------------------------
>7131_7131_6_ASH2L-MGME1_ASH2L_chr8_37971805_ENST00000250635_MGME1_chr20_17970582_ENST00000377704_length(transcript)=1923nt_BP=739nt
CACAGCAACGCGCGCGAGAGAAGAGAGTATTCTCGCGAGAAGTCCAGGGGTGGCCGTGATGGCGGCGGCAGGAGCAGGACCTGGCCAGGA
AGCGGGTGCCGGGCCTGGCCCAGGAGCGGTCGCAAATGCAACAGGGGCAGAAGAGGGGGAGATGAAGCCGGTGGCAGCGGGAGCAGCCGC
TCCTCCTGGAGAGGGGATCTCTGCTGCTCCGACAGTTGAGCCCAGTTCCGGGGAGGCTGAAGGCGGGGAGGCAAACTTGGTCGATGTAAG
CGGTGGCTTGGAGACAGAATCATCTAATGGAAAAGATACACTAGAAGGTGCTGGGGATACATCAGAGGTGATGGATACTCAGGCGGGCTC
CGTGGATGAAGAGAATGGCCGACAGTTGGGTGAGGTAGAGCTGCAATGTGGGATTTGTACAAAATGGTTCACGGCTGACACATTTGGCAT
AGATACCTCATCCTGTCTACCTTTCATGACCAACTACAGTTTTCATTGCAACGTCTGCCATCACAGTGGGAATACCTATTTCCTCCGGAA
GCAAGCAAACTTGAAGGAAATGTGCCTTAGTGCTTTGGCCAACCTGACATGGCAGTCCCGAACACAGGATGAACATCCGAAGACAATGTT
CTCCAAAGATAAGGATATTATACCATTTATTGATAAATACTGGGAGTGCATGACAACCAGACAGAGACCTGGGAAAATGACTTGGCCAAA
TAACATTGTTAAAACAATGGTTCAATGTGGCTTAATTGTGGTGGCCTACAAAGATGGATCACCTGCCCACCCACATTTCATGGATGCAGA
GCTCTGTTCCCAGTACTGGACCAAGTGGCTTCTTCGACTAGAAGAATATACGGAAAAGAAAAAGAACCAGAATATTCAGAAACCAGAATA
TTCAGAATAGGGAGCAAGTTGCTATTTGGGAACATTCAGCACCTTCTCACAGTTTGGGAACATATATTGCTGTTTACTCCAGTGTAAAAA
TGAGGTGCCACTGGATCTGAGTGCTACACGAACACAAGTAGAAGTATTAATTTGTTGAAATGTGTTGTTACCAAAAAGACTGAAAAGCCC
CAAAGTCTAGATATAAAGACCTAGACTTCGGCACGCGAAATCCCAGCTATGCTACCTCTTATTTACCTGAAAGGAGGACACGCAGGATGG
GCAGTCATGCTGGTGACTCTTGTACTCCCTTGAGGGACATTGGGGGGGGGGGGGCGTGGTCCCAGGCAGGATGCCCAGTCTTTGAGCTGA
GATTGGAAGGCAGTGAGGCTGAGGGTGCCAAGATTTCCCCAGGGTTCACCCAGAGGGGAAGGGGCTACATGCCCCCAGCTGTGTGCAGGG
AGGACACATCAGCCCACTACCGCTGCCAACACCAATGCCTAAAACTTGTTTCATACATTGGGGTTTTCTATATATTTCAGCTGGGAAAAG
CTTACATTTAACCTTTTGAAAAAATAAATACGTGATTAGCCTCAACTAAACATTGCTGACTATAAAGACAGTATATTCACCATGTCGCTG
GCAATATGTCATTGCGTAACACCAAATAACCCCCCAGAAGTAGCCAGAGGCCAGTTTGAACATCACAATTCTAAGTGTTTTAGTAACTAT
TTCTGGCGTGAGTCAACAGATCATGTAGATAGAGTCAATTATTGTTTGTGGAGTTTTTCAGCTATAGGGGAGGGGAACTATTAAAATCCA
TTTGTTTCTATTCAATAGGTAATAAAAATTAGTTGTCCCTGGGTTTGGGAAACTTAAATGCCCATTACAGCCCTGGGGAAGGGTTTTCTG
TCTTATGGAGTGAGTCTTAGCATTTAAGTTATACAGTTGCTGCCTTAAAATAGTAGCCTGCTACAATGACTTCTTTGGGTAGCCATTTTC
ATAAGAAATAAAATACAAGATATGAGTAATGAA

>7131_7131_6_ASH2L-MGME1_ASH2L_chr8_37971805_ENST00000250635_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=283AA_BP=227
MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGD
TSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQS
RTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMVQCGLIVVAYKDGSPAHPHFMDAELCSQYWTKWLLRLEEYTEK
KKNQNIQKPEYSE

--------------------------------------------------------------
>7131_7131_7_ASH2L-MGME1_ASH2L_chr8_37971805_ENST00000343823_MGME1_chr20_17970582_ENST00000377704_length(transcript)=2174nt_BP=990nt
GCAGAATATCCAGTCGTAGCCACGAAAATACGCCGCGTCAGTCCCTGACTCGAAAGGAAGTCCTCCAGAGAGCCGCACTAACCATCTAGC
TTCCTCCACCTTCAGCCTGCCAGGCCCGCGGCCACCGCCGGCGCGGGAGGCCGGCCCACCTCTGCCCGCGCGCCTGGCCTTAAAGCGGTC
GTGGAATTATGCTTCCTCAGGCAGGCGGTGGACGCACCGCGGGCTTTTTCTGTTTGAAGACTACAGCGTCACACAGCAACGCGCGCGAGA
GAAGAGAGTATTCTCGCGAGAAGTCCAGGGGTGGCCGTGATGGCGGCGGCAGGAGCAGGACCTGGCCAGGAAGCGGGTGCCGGGCCTGGC
CCAGGAGCGGTCGCAAATGCAACAGGGGCAGAAGAGGGGGAGATGAAGCCGGTGGCAGCGGGAGCAGCCGCTCCTCCTGGAGAGGGGATC
TCTGCTGCTCCGACAGTTGAGCCCAGTTCCGGGGAGGCTGAAGGCGGGGAGGCAAACTTGGTCGATGTAAGCGGTGGCTTGGAGACAGAA
TCATCTAATGGAAAAGATACACTAGAAGGTGCTGGGGATACATCAGAGGTGATGGATACTCAGGCGGGCTCCGTGGATGAAGAGAATGGC
CGACAGTTGGGTGAGGTAGAGCTGCAATGTGGGATTTGTACAAAATGGTTCACGGCTGACACATTTGGCATAGATACCTCATCCTGTCTA
CCTTTCATGACCAACTACAGTTTTCATTGCAACGTCTGCCATCACAGTGGGAATACCTATTTCCTCCGGAAGCAAGCAAACTTGAAGGAA
ATGTGCCTTAGTGCTTTGGCCAACCTGACATGGCAGTCCCGAACACAGGATGAACATCCGAAGACAATGTTCTCCAAAGATAAGGATATT
ATACCATTTATTGATAAATACTGGGAGTGCATGACAACCAGACAGAGACCTGGGAAAATGACTTGGCCAAATAACATTGTTAAAACAATG
GTTCAATGTGGCTTAATTGTGGTGGCCTACAAAGATGGATCACCTGCCCACCCACATTTCATGGATGCAGAGCTCTGTTCCCAGTACTGG
ACCAAGTGGCTTCTTCGACTAGAAGAATATACGGAAAAGAAAAAGAACCAGAATATTCAGAAACCAGAATATTCAGAATAGGGAGCAAGT
TGCTATTTGGGAACATTCAGCACCTTCTCACAGTTTGGGAACATATATTGCTGTTTACTCCAGTGTAAAAATGAGGTGCCACTGGATCTG
AGTGCTACACGAACACAAGTAGAAGTATTAATTTGTTGAAATGTGTTGTTACCAAAAAGACTGAAAAGCCCCAAAGTCTAGATATAAAGA
CCTAGACTTCGGCACGCGAAATCCCAGCTATGCTACCTCTTATTTACCTGAAAGGAGGACACGCAGGATGGGCAGTCATGCTGGTGACTC
TTGTACTCCCTTGAGGGACATTGGGGGGGGGGGGGCGTGGTCCCAGGCAGGATGCCCAGTCTTTGAGCTGAGATTGGAAGGCAGTGAGGC
TGAGGGTGCCAAGATTTCCCCAGGGTTCACCCAGAGGGGAAGGGGCTACATGCCCCCAGCTGTGTGCAGGGAGGACACATCAGCCCACTA
CCGCTGCCAACACCAATGCCTAAAACTTGTTTCATACATTGGGGTTTTCTATATATTTCAGCTGGGAAAAGCTTACATTTAACCTTTTGA
AAAAATAAATACGTGATTAGCCTCAACTAAACATTGCTGACTATAAAGACAGTATATTCACCATGTCGCTGGCAATATGTCATTGCGTAA
CACCAAATAACCCCCCAGAAGTAGCCAGAGGCCAGTTTGAACATCACAATTCTAAGTGTTTTAGTAACTATTTCTGGCGTGAGTCAACAG
ATCATGTAGATAGAGTCAATTATTGTTTGTGGAGTTTTTCAGCTATAGGGGAGGGGAACTATTAAAATCCATTTGTTTCTATTCAATAGG
TAATAAAAATTAGTTGTCCCTGGGTTTGGGAAACTTAAATGCCCATTACAGCCCTGGGGAAGGGTTTTCTGTCTTATGGAGTGAGTCTTA
GCATTTAAGTTATACAGTTGCTGCCTTAAAATAGTAGCCTGCTACAATGACTTCTTTGGGTAGCCATTTTCATAAGAAATAAAATACAAG
ATATGAGTAATGAA

>7131_7131_7_ASH2L-MGME1_ASH2L_chr8_37971805_ENST00000343823_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=283AA_BP=227
MAAAGAGPGQEAGAGPGPGAVANATGAEEGEMKPVAAGAAAPPGEGISAAPTVEPSSGEAEGGEANLVDVSGGLETESSNGKDTLEGAGD
TSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQS
RTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMVQCGLIVVAYKDGSPAHPHFMDAELCSQYWTKWLLRLEEYTEK
KKNQNIQKPEYSE

--------------------------------------------------------------
>7131_7131_8_ASH2L-MGME1_ASH2L_chr8_37971805_ENST00000428278_MGME1_chr20_17970582_ENST00000377704_length(transcript)=2024nt_BP=840nt
ATCCCGCGGCTCCTGGAGCCCTGCCGCCCGCCCCCTGCGAACCCAGGCCCCGCCGCCAATGGCTCGCCCTGCCTCTGCGCCGCTTGGCCC
GTCCCCTCTCAAGCATATCTCGGATAACGCCCCTTCCGCACCTTTCACGGGCGGTGGGAGCTGAGGCTCCTGTCGTTATCTCTGATCCTT
GCACCCTGGCAGGAAGCTGGTAGCTCACACTTTAACGGGAGGCCTTCACATATTCCAGAAAAGAAACCACTTTGCAGTGCCAGACTGGAA
GAAGTAACGGTCACTCTGAAAACAGGGTGGGAGAGCTGCCTCTCTTTGAACCTCTCCCAGGACCAACTCTAACCCAGGGAGGCAAACTTG
GTCGATGTAAGCGGTGGCTTGGAGACAGAATCATCTAATGGAAAAGATACACTAGAAGGTGCTGGGGATACATCAGAGGTGATGGATACT
CAGGCGGGCTCCGTGGATGAAGAGAATGGCCGACAGTTGGGTGAGGTAGAGCTGCAATGTGGGATTTGTACAAAATGGTTCACGGCTGAC
ACATTTGGCATAGATACCTCATCCTGTCTACCTTTCATGACCAACTACAGTTTTCATTGCAACGTCTGCCATCACAGTGGGAATACCTAT
TTCCTCCGGAAGCAAGCAAACTTGAAGGAAATGTGCCTTAGTGCTTTGGCCAACCTGACATGGCAGTCCCGAACACAGGATGAACATCCG
AAGACAATGTTCTCCAAAGATAAGGATATTATACCATTTATTGATAAATACTGGGAGTGCATGACAACCAGACAGAGACCTGGGAAAATG
ACTTGGCCAAATAACATTGTTAAAACAATGGTTCAATGTGGCTTAATTGTGGTGGCCTACAAAGATGGATCACCTGCCCACCCACATTTC
ATGGATGCAGAGCTCTGTTCCCAGTACTGGACCAAGTGGCTTCTTCGACTAGAAGAATATACGGAAAAGAAAAAGAACCAGAATATTCAG
AAACCAGAATATTCAGAATAGGGAGCAAGTTGCTATTTGGGAACATTCAGCACCTTCTCACAGTTTGGGAACATATATTGCTGTTTACTC
CAGTGTAAAAATGAGGTGCCACTGGATCTGAGTGCTACACGAACACAAGTAGAAGTATTAATTTGTTGAAATGTGTTGTTACCAAAAAGA
CTGAAAAGCCCCAAAGTCTAGATATAAAGACCTAGACTTCGGCACGCGAAATCCCAGCTATGCTACCTCTTATTTACCTGAAAGGAGGAC
ACGCAGGATGGGCAGTCATGCTGGTGACTCTTGTACTCCCTTGAGGGACATTGGGGGGGGGGGGGCGTGGTCCCAGGCAGGATGCCCAGT
CTTTGAGCTGAGATTGGAAGGCAGTGAGGCTGAGGGTGCCAAGATTTCCCCAGGGTTCACCCAGAGGGGAAGGGGCTACATGCCCCCAGC
TGTGTGCAGGGAGGACACATCAGCCCACTACCGCTGCCAACACCAATGCCTAAAACTTGTTTCATACATTGGGGTTTTCTATATATTTCA
GCTGGGAAAAGCTTACATTTAACCTTTTGAAAAAATAAATACGTGATTAGCCTCAACTAAACATTGCTGACTATAAAGACAGTATATTCA
CCATGTCGCTGGCAATATGTCATTGCGTAACACCAAATAACCCCCCAGAAGTAGCCAGAGGCCAGTTTGAACATCACAATTCTAAGTGTT
TTAGTAACTATTTCTGGCGTGAGTCAACAGATCATGTAGATAGAGTCAATTATTGTTTGTGGAGTTTTTCAGCTATAGGGGAGGGGAACT
ATTAAAATCCATTTGTTTCTATTCAATAGGTAATAAAAATTAGTTGTCCCTGGGTTTGGGAAACTTAAATGCCCATTACAGCCCTGGGGA
AGGGTTTTCTGTCTTATGGAGTGAGTCTTAGCATTTAAGTTATACAGTTGCTGCCTTAAAATAGTAGCCTGCTACAATGACTTCTTTGGG
TAGCCATTTTCATAAGAAATAAAATACAAGATATGAGTAATGAA

>7131_7131_8_ASH2L-MGME1_ASH2L_chr8_37971805_ENST00000428278_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=217AA_BP=161
MVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNT
YFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMVQCGLIVVAYKDGSPAHPH
FMDAELCSQYWTKWLLRLEEYTEKKKNQNIQKPEYSE

--------------------------------------------------------------
>7131_7131_9_ASH2L-MGME1_ASH2L_chr8_37971805_ENST00000521652_MGME1_chr20_17970582_ENST00000377704_length(transcript)=1878nt_BP=694nt
GGAGCTGAGGCTCCTGTCGTTATCTCTGATCCTTGCACCCTGGCAGGAAGCTGGTAGCTCACACTTTAACGGGAGGCCTTCACATATTCC
AGAAAAGAAACCACTTTGCAGTGCCAGACTGGAAGAAGTAACGGTCACTCTGAAAACAGGGTGGGAGAGCTGCCTCTCTTTGAACCTCTC
CCAGGACCAACTCTAACCCAGGGAGGCAAACTTGGTCGATGTAAGCGGTGGCTTGGAGACAGAATCATCTAATGGAAAAGATACACTAGA
AGGTGCTGGGGATACATCAGAGGTGATGGATACTCAGGCGGGCTCCGTGGATGAAGAGAATGGCCGACAGTTGGGTGAGGTAGAGCTGCA
ATGTGGGATTTGTACAAAATGGTTCACGGCTGACACATTTGGCATAGATACCTCATCCTGTCTACCTTTCATGACCAACTACAGTTTTCA
TTGCAACGTCTGCCATCACAGTGGGAATACCTATTTCCTCCGGAAGCAAGCAAACTTGAAGGAAATGTGCCTTAGTGCTTTGGCCAACCT
GACATGGCAGTCCCGAACACAGGATGAACATCCGAAGACAATGTTCTCCAAAGATAAGGATATTATACCATTTATTGATAAATACTGGGA
GTGCATGACAACCAGACAGAGACCTGGGAAAATGACTTGGCCAAATAACATTGTTAAAACAATGGTTCAATGTGGCTTAATTGTGGTGGC
CTACAAAGATGGATCACCTGCCCACCCACATTTCATGGATGCAGAGCTCTGTTCCCAGTACTGGACCAAGTGGCTTCTTCGACTAGAAGA
ATATACGGAAAAGAAAAAGAACCAGAATATTCAGAAACCAGAATATTCAGAATAGGGAGCAAGTTGCTATTTGGGAACATTCAGCACCTT
CTCACAGTTTGGGAACATATATTGCTGTTTACTCCAGTGTAAAAATGAGGTGCCACTGGATCTGAGTGCTACACGAACACAAGTAGAAGT
ATTAATTTGTTGAAATGTGTTGTTACCAAAAAGACTGAAAAGCCCCAAAGTCTAGATATAAAGACCTAGACTTCGGCACGCGAAATCCCA
GCTATGCTACCTCTTATTTACCTGAAAGGAGGACACGCAGGATGGGCAGTCATGCTGGTGACTCTTGTACTCCCTTGAGGGACATTGGGG
GGGGGGGGGCGTGGTCCCAGGCAGGATGCCCAGTCTTTGAGCTGAGATTGGAAGGCAGTGAGGCTGAGGGTGCCAAGATTTCCCCAGGGT
TCACCCAGAGGGGAAGGGGCTACATGCCCCCAGCTGTGTGCAGGGAGGACACATCAGCCCACTACCGCTGCCAACACCAATGCCTAAAAC
TTGTTTCATACATTGGGGTTTTCTATATATTTCAGCTGGGAAAAGCTTACATTTAACCTTTTGAAAAAATAAATACGTGATTAGCCTCAA
CTAAACATTGCTGACTATAAAGACAGTATATTCACCATGTCGCTGGCAATATGTCATTGCGTAACACCAAATAACCCCCCAGAAGTAGCC
AGAGGCCAGTTTGAACATCACAATTCTAAGTGTTTTAGTAACTATTTCTGGCGTGAGTCAACAGATCATGTAGATAGAGTCAATTATTGT
TTGTGGAGTTTTTCAGCTATAGGGGAGGGGAACTATTAAAATCCATTTGTTTCTATTCAATAGGTAATAAAAATTAGTTGTCCCTGGGTT
TGGGAAACTTAAATGCCCATTACAGCCCTGGGGAAGGGTTTTCTGTCTTATGGAGTGAGTCTTAGCATTTAAGTTATACAGTTGCTGCCT
TAAAATAGTAGCCTGCTACAATGACTTCTTTGGGTAGCCATTTTCATAAGAAATAAAATACAAGATATGAGTAATGAA

>7131_7131_9_ASH2L-MGME1_ASH2L_chr8_37971805_ENST00000521652_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=217AA_BP=161
MVDVSGGLETESSNGKDTLEGAGDTSEVMDTQAGSVDEENGRQLGEVELQCGICTKWFTADTFGIDTSSCLPFMTNYSFHCNVCHHSGNT
YFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMVQCGLIVVAYKDGSPAHPH
FMDAELCSQYWTKWLLRLEEYTEKKKNQNIQKPEYSE

--------------------------------------------------------------
>7131_7131_10_ASH2L-MGME1_ASH2L_chr8_37971805_ENST00000545394_MGME1_chr20_17970582_ENST00000377704_length(transcript)=1720nt_BP=536nt
GATGGCGGCGGCAGGAGCAGGACCTGGCCAGGAAGCGGGTGCCGGGCCTGGCCCAGGAGCGGTCGCAAATGCAACAGGGGCAGAAGAGGG
GGAGATGAAGCCGGTGGCAGCGGGAGCAGCCGCTCCTCCTGGAGAGGGGATCTCTGCTGCTCCGACAGTTGAGCCCAGTTCCGGGGAGGC
TGAAGGCGGGGAGGCAAACTTGGTCGATGTAAGCGGTGGCTTGGAGACAGAATCATCTAATGGAAAAGATACACTAATCCTGTCTACCTT
TCATGACCAACTACAGTTTTCATTGCAACGTCTGCCATCACAGTGGGAATACCTATTTCCTCCGGAAGCAAGCAAACTTGAAGGAAATGT
GCCTTAGTGCTTTGGCCAACCTGACATGGCAGTCCCGAACACAGGATGAACATCCGAAGACAATGTTCTCCAAAGATAAGGATATTATAC
CATTTATTGATAAATACTGGGAGTGCATGACAACCAGACAGAGACCTGGGAAAATGACTTGGCCAAATAACATTGTTAAAACAATGGTTC
AATGTGGCTTAATTGTGGTGGCCTACAAAGATGGATCACCTGCCCACCCACATTTCATGGATGCAGAGCTCTGTTCCCAGTACTGGACCA
AGTGGCTTCTTCGACTAGAAGAATATACGGAAAAGAAAAAGAACCAGAATATTCAGAAACCAGAATATTCAGAATAGGGAGCAAGTTGCT
ATTTGGGAACATTCAGCACCTTCTCACAGTTTGGGAACATATATTGCTGTTTACTCCAGTGTAAAAATGAGGTGCCACTGGATCTGAGTG
CTACACGAACACAAGTAGAAGTATTAATTTGTTGAAATGTGTTGTTACCAAAAAGACTGAAAAGCCCCAAAGTCTAGATATAAAGACCTA
GACTTCGGCACGCGAAATCCCAGCTATGCTACCTCTTATTTACCTGAAAGGAGGACACGCAGGATGGGCAGTCATGCTGGTGACTCTTGT
ACTCCCTTGAGGGACATTGGGGGGGGGGGGGCGTGGTCCCAGGCAGGATGCCCAGTCTTTGAGCTGAGATTGGAAGGCAGTGAGGCTGAG
GGTGCCAAGATTTCCCCAGGGTTCACCCAGAGGGGAAGGGGCTACATGCCCCCAGCTGTGTGCAGGGAGGACACATCAGCCCACTACCGC
TGCCAACACCAATGCCTAAAACTTGTTTCATACATTGGGGTTTTCTATATATTTCAGCTGGGAAAAGCTTACATTTAACCTTTTGAAAAA
ATAAATACGTGATTAGCCTCAACTAAACATTGCTGACTATAAAGACAGTATATTCACCATGTCGCTGGCAATATGTCATTGCGTAACACC
AAATAACCCCCCAGAAGTAGCCAGAGGCCAGTTTGAACATCACAATTCTAAGTGTTTTAGTAACTATTTCTGGCGTGAGTCAACAGATCA
TGTAGATAGAGTCAATTATTGTTTGTGGAGTTTTTCAGCTATAGGGGAGGGGAACTATTAAAATCCATTTGTTTCTATTCAATAGGTAAT
AAAAATTAGTTGTCCCTGGGTTTGGGAAACTTAAATGCCCATTACAGCCCTGGGGAAGGGTTTTCTGTCTTATGGAGTGAGTCTTAGCAT
TTAAGTTATACAGTTGCTGCCTTAAAATAGTAGCCTGCTACAATGACTTCTTTGGGTAGCCATTTTCATAAGAAATAAAATACAAGATAT
GAGTAATGAA

>7131_7131_10_ASH2L-MGME1_ASH2L_chr8_37971805_ENST00000545394_MGME1_chr20_17970582_ENST00000377704_length(amino acids)=144AA_BP=88
MTNYSFHCNVCHHSGNTYFLRKQANLKEMCLSALANLTWQSRTQDEHPKTMFSKDKDIIPFIDKYWECMTTRQRPGKMTWPNNIVKTMVQ
CGLIVVAYKDGSPAHPHFMDAELCSQYWTKWLLRLEEYTEKKKNQNIQKPEYSE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ASH2L-MGME1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneASH2Lchr8:37968351chr20:17970582ENST00000250635+515316_628101.0502.0RBBP5
HgeneASH2Lchr8:37968351chr20:17970582ENST00000343823+516316_628195.0629.0RBBP5
HgeneASH2Lchr8:37968351chr20:17970582ENST00000428278+516316_628101.0535.0RBBP5
HgeneASH2Lchr8:37968351chr20:17970582ENST00000521652+515316_628101.0502.0RBBP5
HgeneASH2Lchr8:37971805chr20:17970582ENST00000250635+615316_628133.0502.0RBBP5
HgeneASH2Lchr8:37971805chr20:17970582ENST00000343823+616316_628227.0629.0RBBP5
HgeneASH2Lchr8:37971805chr20:17970582ENST00000428278+616316_628133.0535.0RBBP5
HgeneASH2Lchr8:37971805chr20:17970582ENST00000521652+615316_628133.0502.0RBBP5


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ASH2L-MGME1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ASH2L-MGME1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0013911Emaciation1CTD_human
TgeneC0029089Ophthalmoplegia1CTD_human
TgeneC0035229Respiratory Insufficiency1CTD_human
TgeneC0162292External Ophthalmoplegia1CTD_human
TgeneC0235063Respiratory Depression1CTD_human
TgeneC0339693Internal Ophthalmoplegia1CTD_human
TgeneC0751401Ophthalmoparesis1CTD_human
TgeneC0751651Mitochondrial Diseases1CTD_human
TgeneC0949855Electron Transport Chain Deficiencies, Mitochondrial1CTD_human
TgeneC0949856Oxidative Phosphorylation Deficiencies1CTD_human
TgeneC0949857Mitochondrial Respiratory Chain Deficiencies1CTD_human
TgeneC1145670Respiratory Failure1CTD_human
TgeneC3554462MITOCHONDRIAL DNA DEPLETION SYNDROME 111CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT