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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ADCK2-DPP6 (FusionGDB2 ID:HG90956TG1804)

Fusion Gene Summary for ADCK2-DPP6

check button Fusion gene summary
Fusion gene informationFusion gene name: ADCK2-DPP6
Fusion gene ID: hg90956tg1804
HgeneTgene
Gene symbol

ADCK2

DPP6

Gene ID

90956

1804

Gene nameaarF domain containing kinase 2dipeptidyl peptidase like 6
SynonymsAARFDPL1|DPPX|MRD33|VF2
Cytomap('ADCK2')('DPP6')

7q34

7q36.2

Type of geneprotein-codingprotein-coding
Descriptionuncharacterized aarF domain-containing protein kinase 2putative ubiquinone biosynthesis protein AarFdipeptidyl aminopeptidase-like protein 6DPP VIdipeptidyl aminopeptidase IV-related proteindipeptidyl peptidase IV-related proteindipeptidyl peptidase VIdipeptidyl-peptidase 6
Modification date2020031320200313
UniProtAcc.

P42658

Ensembl transtripts involved in fusion geneENST00000072869, ENST00000476491, 
Fusion gene scores* DoF score3 X 3 X 3=2717 X 17 X 7=2023
# samples 319
** MAII scorelog2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(19/2023*10)=-3.41242499622733
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ADCK2 [Title/Abstract] AND DPP6 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointADCK2(140390613)-DPP6(154429531), # samples:3
Anticipated loss of major functional domain due to fusion event.ADCK2-DPP6 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ADCK2-DPP6 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDPP6

GO:1901379

regulation of potassium ion transmembrane transport

18364354


check buttonFusion gene breakpoints across ADCK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across DPP6 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A8-A07I-01AADCK2chr7

140390613

-DPP6chr7

154429531

+
ChimerDB4BRCATCGA-A8-A07I-01AADCK2chr7

140390613

+DPP6chr7

154429531

+


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Fusion Gene ORF analysis for ADCK2-DPP6

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000072869ENST00000332007ADCK2chr7

140390613

+DPP6chr7

154429531

+
5CDS-intronENST00000072869ENST00000377770ADCK2chr7

140390613

+DPP6chr7

154429531

+
5CDS-intronENST00000072869ENST00000406326ADCK2chr7

140390613

+DPP6chr7

154429531

+
5CDS-intronENST00000072869ENST00000427557ADCK2chr7

140390613

+DPP6chr7

154429531

+
5CDS-intronENST00000072869ENST00000496611ADCK2chr7

140390613

+DPP6chr7

154429531

+
5CDS-intronENST00000476491ENST00000332007ADCK2chr7

140390613

+DPP6chr7

154429531

+
5CDS-intronENST00000476491ENST00000377770ADCK2chr7

140390613

+DPP6chr7

154429531

+
5CDS-intronENST00000476491ENST00000406326ADCK2chr7

140390613

+DPP6chr7

154429531

+
5CDS-intronENST00000476491ENST00000427557ADCK2chr7

140390613

+DPP6chr7

154429531

+
5CDS-intronENST00000476491ENST00000496611ADCK2chr7

140390613

+DPP6chr7

154429531

+
In-frameENST00000072869ENST00000404039ADCK2chr7

140390613

+DPP6chr7

154429531

+
In-frameENST00000476491ENST00000404039ADCK2chr7

140390613

+DPP6chr7

154429531

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000072869ADCK2chr7140390613+ENST00000404039DPP6chr7154429531+5694191817838881236
ENST00000476491ADCK2chr7140390613+ENST00000404039DPP6chr7154429531+5694191817838881236

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000072869ENST00000404039ADCK2chr7140390613+DPP6chr7154429531+0.0009113420.99908864
ENST00000476491ENST00000404039ADCK2chr7140390613+DPP6chr7154429531+0.0009113420.99908864

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Fusion Genomic Features for ADCK2-DPP6


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ADCK2chr7140390613+DPP6chr7154429530+5.17E-050.9999484
ADCK2chr7140390613+DPP6chr7154429530+5.17E-050.9999484

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ADCK2-DPP6


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:140390613/chr7:154429531)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DPP6

P42658

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Promotes cell surface expression of the potassium channel KCND2 (PubMed:15454437, PubMed:19441798). Modulates the activity and gating characteristics of the potassium channel KCND2 (PubMed:18364354). Has no dipeptidyl aminopeptidase activity (PubMed:8103397, PubMed:15476821). {ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:18364354, ECO:0000269|PubMed:8103397, ECO:0000305|PubMed:15476821}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADCK2chr7:140390613chr7:154429531ENST00000072869+78206_214580627.0Nucleotide bindingATP
HgeneADCK2chr7:140390613chr7:154429531ENST00000072869+78103_123580627.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneADCK2chr7:140390613chr7:154429531ENST00000072869+78200_618580627.0DomainNote=Protein kinase
TgeneDPP6chr7:140390613chr7:154429531ENST00000332007426117_865147804.0Topological domainExtracellular
TgeneDPP6chr7:140390613chr7:154429531ENST000003320074261_95147804.0Topological domainCytoplasmic
TgeneDPP6chr7:140390613chr7:154429531ENST00000377770426117_865209866.0Topological domainExtracellular
TgeneDPP6chr7:140390613chr7:154429531ENST000003777704261_95209866.0Topological domainCytoplasmic
TgeneDPP6chr7:140390613chr7:154429531ENST0000033200742696_116147804.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneDPP6chr7:140390613chr7:154429531ENST0000037777042696_116209866.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for ADCK2-DPP6


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>2192_2192_1_ADCK2-DPP6_ADCK2_chr7_140390613_ENST00000072869_DPP6_chr7_154429531_ENST00000404039_length(transcript)=5694nt_BP=1918nt
GGCGCGGGCCTCCGGCCTGAGGCCCGGCGAGGTGCTGGAGGGAGCGGGGCGCGGATCCGGCCCAGATGGGCAGCTCCGTCCGCGGGGTCA
GGGCCGGGCTTCGGCTTCACCGCAGCCTCGCCTGAGCGGGCGCCTCTGAAGTGGAGGGCGGGCCGCCTGGGCCGCGGGCCTCGGGAGGAT
GGTGGCGCCCTGGCGCGTCTCCGTCAGGGTTTGCCTGTCGCACCTGAGGTGCTTCGAGCTCAGACAGGGACTCAGCCTCCTGAGGCCCTC
CGAGTGCCCTCGCGATGCCAGGCTCTGCTGGCTTCTGCTGGGCACTTTGCCCAAGGTCGTCTCCCTGTGCGGGGACGTGGGTGAGGGGGC
CCCTGACGTTCTGAGTCGGCGAAGGGTCCGCTGCAGCGGGGCGGCTGGCGCGGGGCCCGCGGAGAGCCTCCCCCGAGCGGGACCTCTGGG
CGGCGTCTTCCTGCATCTCCGCCTCTGGCTTCGCGCCGGCGCTCTGTTGGTGAAATTCTTCCCCCTCCTACTCCTCTACCCCCTCACCTA
CCTGGCTCCCAGCGTCTCCACCCTCTGGCTCCACCTGCTTCTGAAAGCCACCGAGACCTCAGGCCCAACCTACATCAAACTGGGCCAGTG
GGCCAGCACCCGGCGCGATCTGTTTTCGGAGGCTTTCTGTGCCCAATTTTCCAAGCTGCATGTCCGAGTGACGCCCCACCCGTGGACTCA
CACTGAGCGCTTCCTTCGGCAGGCTTTTGGGGATGACTGGGGGAGCATCCTCTCTTTTGAGAACCGGGAACCTGTGGGCTCAGGCTGCGT
GGCCCAGGTGTACAAAGCATACGCCAACACTGCCTTCCTGGAGACTGACAGCGTCCAGAGACTTGGCAGGGCCTCCTGTCTGCCGCCCTT
CTCACATACTGGGGCAGTCGGTGGGCTGAGAGAGCTCTTTGGATACCTTGGAAATGGCCGGAAACCTCCAGAAAATCTCGCAGACCAGTC
GTTTCTAGAAAGGCTGCTCCTCCCTAAAGCTGACCTGGTTGGATCAAATGCAGGGGTGTCTCGGGCTCAGGTCCCTGGCCACCAACCTGA
GGCCACCAACCTCATCTCCGTGGCAGTGAAAGTGTTGCACCCTGGCCTGCTCGCTCAGGTGCATATGGACCTGCTGCTGATGAAGATTGG
CAGCCGAGTCCTGGGAGTTTTGCCAGGCATCAAGTGGCTTAGCTTGCCTGAGATTGTGGAGGAATTTGAGAAGCTGATGGTCCAACAGAT
TGACCTGCGTTACGAAGCTCAGAATCTAGAACACTTCCAGGTCAACTTCCGGAATGTGAAAGCCGTCAAGTTCCCCACCCCTCTGCGCCC
CTTTGTCACCAGAGAAGTCTTGGTGGAAACGTATGAAGAGAGTGTGCCTGTGTCCAGTTACCAGCAGGCAGGAATTCCCGTGGACTTGAA
AAGGAAGATTGCACGGCTGGGGATCAACATGCTCCTGAAGATGATATTTGTGGATAACTTTGTCCATGCAGACCTTCACCCTGGAAACAT
CCTGGTTCAGGGTGCCAACGGCCTGTCCTCGAGTCAGGAGGCGCAGCTGCAGCAGGCGGACATCTGTGACACTCTGGTGGTGGCCGTGCC
ATCTTCCCTCTGCCCGCTGCGACTGGTGCTGCTGGATGCTGGCATTGTGGCGGAGCTGCAGGCCCCTGACCTGAGGAATTTCCGGGCAGT
TTTCATGGCTGTGGTGATGGGGCAGGGCCAGAGAGTGGCTGAGCTGATCCTGCATCATGCCCGGGCCAGCGAGTGCAGGGACGTGGAGGG
GTTCAAAACCGAGATGGCCATGCTGGTGACCCAGGCCAGGAAGAACACCATCACCCTGGAGAAGCTTCATGTGTCCAGCCTTCTCTCTAG
TGTCTTTAAGTTGCTGATGACTCACAAGATATATCAACACTCGTATACTGGATATTACGTCCTGAGCAAAATTCCTCATGGGGATCCTCA
AAGTCTGGACCCACCAGAAGTCAGCAATGCAAAACTTCAGTATGCAGGATGGGGCCCTAAAGGCCAACAGCTGATATTTATTTTTGAAAA
CAATATCTACTACTGTGCACATGTCGGGAAACAGGCCATCCGTGTGGTCTCCACTGGCAAGGAAGGTGTGATTTACAATGGCCTCAGTGA
CTGGCTGTATGAAGAGGAGATTTTGAAGACACACATCGCACACTGGTGGTCTCCGGATGGCACGAGACTCGCCTACGCCGCCATCAATGA
TTCCCGTGTCCCCATCATGGAGCTCCCAACTTACACCGGCTCCATCTACCCCACCGTGAAGCCCTACCACTATCCCAAGGCTGGAAGTGA
GAACCCCAGCATTTCCCTACACGTTATTGGCTTAAATGGACCCACCCATGATCTGGAGATGATGCCGCCTGATGATCCACGGATGAGGGA
GTACTACATCACCATGGTGAAGTGGGCCACCAGCACCAAGGTCGCCGTGACCTGGCTGAACCGGGCGCAGAACGTGTCCATCCTCACCCT
CTGCGACGCCACCACGGGGGTCTGCACGAAGAAACACGAGGATGAAAGTGAGGCCTGGCTCCACAGACAGAATGAAGAACCTGTGTTCTC
CAAGGATGGCCGAAAGTTTTTCTTCATCAGAGCCATCCCCCAGGGAGGACGAGGGAAATTCTATCACATCACGGTGTCCTCGTCCCAGCC
CAACAGCAGCAACGACAACATCCAGTCCATCACCTCCGGGGACTGGGACGTGACCAAGATCCTAGCCTACGATGAGAAGGGGAATAAGAT
CTACTTCCTGAGCACGGAGGACCTGCCTCGGAGACGACAACTCTACAGTGCCAACACGGTGGGCAACTTCAACAGGCAGTGCCTCTCCTG
TGACCTGGTTGAGAACTGCACCTACTTCAGCGCTTCCTTCAGCCATAGCATGGACTTCTTCCTGCTCAAGTGCGAAGGTCCTGGTGTTCC
TATGGTGACGGTGCACAACACAACAGATAAGAAAAAAATGTTTGACCTAGAAACAAATGAACATGTCAAGAAGGCCATAAATGACCGACA
GATGCCTAAAGTGGAATACAGGGACATTGAGATTGATGATTACAACCTGCCCATGCAGATACTGAAGCCAGCAACCTTCACCGACACCAC
CCACTACCCTCTGCTCCTGGTGGTGGATGGCACCCCAGGCAGCCAGAGTGTGGCTGAGAAGTTCGAGGTGAGCTGGGAGACGGTGATGGT
GAGCAGCCACGGCGCGGTGGTGGTAAAGTGTGACGGCCGTGGCAGCGGCTTCCAAGGGACCAAGCTCCTGCACGAAGTGAGGCGGCGGCT
GGGCTTGCTGGAGGAGAAGGACCAGATGGAGGCCGTGCGGACGATGCTGAAGGAGCAGTACATTGACAGGACGCGCGTGGCCGTGTTTGG
GAAGGATTACGGTGGCTACCTGAGCACCTACATCCTCCCAGCAAAGGGAGAAAATCAAGGCCAGACATTCACCTGCGGCTCTGCTCTCTC
TCCAATAACAGACTTCAAACTCTATGCCTCTGCGTTTTCCGAGAGGTACTTGGGCCTCCATGGACTTGACAACAGAGCATACGAGATGAC
CAAGGTAGCCCATCGAGTCTCCGCGCTGGAAGAACAGCAGTTCCTGATCATTCATCCCACTGCCGATGAAAAAATTCATTTCCAGCACAC
AGCAGAACTCATTACACAACTAATTAGGGGAAAGGCTAATTACAGCTTACAGATTTACCCGGACGAAAGCCATTACTTTACCAGCTCCAG
CCTCAAACAGCATCTGTACCGGTCCATCATCAACTTCTTCGTGGAATGCTTCAGGATCCAGGACAAACTGCTGACAGTCACAGCGAAAGA
GGACGAGGAGGAGGACTAAGCTCAGGTCGCTCTAAGCACAAACGTGGCTCTTTCTACAACCAGATGCAACCGAGGGATTTCCCTGCCCTC
CCTCTTCCCTCGGAGGGGCGGGGCGGGGCGGGGCCGGGTGTTCCATAGCATGTGTGTCTCGGATGCGGAAGGCAGTTTTGCTTGGGAAAC
AAGCTCCTTCCCCGGGGTCATCACTCACGGCCTCCATGGCACCAGGGACAACGCTGTCCCCGCAGCAGCGCCTCCTCCCGGCGCCCGAGA
GACCGGCACGCCACGGCCCCTCCCCCAAGGAACAGAGCAAAGGATGGTGGCCGCAGGCCCCACGCGAGCCCACAGGACACCGGCCCCTAG
ATTCCAGCCACCAAGCGGAAGCATGAGACCCGCCCACACTAGCCTCTGTGTTCCCGTTAGGGACATCACACCCTGTCTCACGTCGCAGTG
CCATGGACGCAGCAGTTACAGCACCATTGTTTTAGCAGTGCGTGTTCATATATGGGCTTGCTACTTCCTGTAATGAGGACGTTCAACATG
GTGAGGGGCTACAAGAAAACGCTTTTCTGTACAGAGTCTTACTGTAGCTACGCTAATGGTTAACCTGATAGAATTAACTCGTATTTTTCT
ATGGTTTTAACCTGATGCTCCACTGTCTCCGTCATGGGGTTGTTTTGCTGTTTGGGGTTGGGCCTTGTTTCCCTTTCCTTTCTCCAGTCC
ACGTGTAGACTTTGCGCTTGATGAAGAAGCAGATCGGAAGTAACTGCTCCCTCCTCAAGGTTGTCTTCAGACGTCTTGGGGACGTTCCTA
AACACTGAGGGGGAAGACAGCCAATAGCACCCATTAAAAGAAATACCTAAATAAAACCTCTCTCCCACTCAGCTATGCTAGGGCTTGGCT
GTAGGTGTGCACTGTCTATTTACATCCGTCCTTACAACCATCCTTGTCCTCCTTGGTACCGTATCAAGCTCTTTCCCATGACATTTGGTT
TAAAAAAAAAAAAAAAAAAAAAAAAAAAACAGAAAAAAGACAAAGCGTCAACTCCACCCACAGGCCCGCTGTGTGTGCTCGGGCCACGGG
AGTCCTGAGGGTTCTGTGGGCCTGCGCGCATCCCTCTCCCATCGTGGGGGTGGCTCCGTGACCTTCCTGCCACGAGCAGGAGGTTGATGA
TGTGCTACGTTAGCCTTGTAAGATACACCCCCACCAAATGTGCAGCCGGTGTTCCCAGTGTATATTTCATTCTCTTGTATATAAAGGAAG
CAATGTGTGTCAGGCCTCTGTGCAGTCAACCCAGCCTCCTCCCGCCAGTGCTAACCCCGTGTTGAGCCTGCATGCTGACACTGTGGCCGA
TCTGGACTCTAGAAGTGCTAGTTTGAAATATATCCATTACTGTCATTTCCTTTTGAGCTTGTGGACAAGCTGAATGTCAGGACTGACTTC
GCCAGCTCCCAGCCCTGCGGGGGTGTCCTTGGCATCCCATCAGCAGAGGAGATGCGTCCCTGTTGCATTTTGGCGTTTGGGGCTTTGGGT
TTATCCACATGAGCTCTGAACGTCCGTTATAGTTAGGGTGATTGGAAGGTCTCCATCACTGGGTGTTTTAAAGGTGATTCACCACCATTT
GTGAAAGGACCAACGTGCTGATAAACAGGACCGATCCGAGTGCTACATGACTGTGCGTTTGCTATTTCAATGGGCCTGAACGACTACAAA
GCCAGCTAGGTCTGGAAGGGGAAGCCAGCTCTGGCCACGACATCTGGTCGGAGGGAAGTGGGGATGTGGCATGGTAGCGTCTGTTCATCC

>2192_2192_1_ADCK2-DPP6_ADCK2_chr7_140390613_ENST00000072869_DPP6_chr7_154429531_ENST00000404039_length(amino acids)=1236AA_BP=580
MVAPWRVSVRVCLSHLRCFELRQGLSLLRPSECPRDARLCWLLLGTLPKVVSLCGDVGEGAPDVLSRRRVRCSGAAGAGPAESLPRAGPL
GGVFLHLRLWLRAGALLVKFFPLLLLYPLTYLAPSVSTLWLHLLLKATETSGPTYIKLGQWASTRRDLFSEAFCAQFSKLHVRVTPHPWT
HTERFLRQAFGDDWGSILSFENREPVGSGCVAQVYKAYANTAFLETDSVQRLGRASCLPPFSHTGAVGGLRELFGYLGNGRKPPENLADQ
SFLERLLLPKADLVGSNAGVSRAQVPGHQPEATNLISVAVKVLHPGLLAQVHMDLLLMKIGSRVLGVLPGIKWLSLPEIVEEFEKLMVQQ
IDLRYEAQNLEHFQVNFRNVKAVKFPTPLRPFVTREVLVETYEESVPVSSYQQAGIPVDLKRKIARLGINMLLKMIFVDNFVHADLHPGN
ILVQGANGLSSSQEAQLQQADICDTLVVAVPSSLCPLRLVLLDAGIVAELQAPDLRNFRAVFMAVVMGQGQRVAELILHHARASECRDVE
GFKTEMAMLVTQARKNTITLEKLHVSSLLSSVFKLLMTHKIYQHSYTGYYVLSKIPHGDPQSLDPPEVSNAKLQYAGWGPKGQQLIFIFE
NNIYYCAHVGKQAIRVVSTGKEGVIYNGLSDWLYEEEILKTHIAHWWSPDGTRLAYAAINDSRVPIMELPTYTGSIYPTVKPYHYPKAGS
ENPSISLHVIGLNGPTHDLEMMPPDDPRMREYYITMVKWATSTKVAVTWLNRAQNVSILTLCDATTGVCTKKHEDESEAWLHRQNEEPVF
SKDGRKFFFIRAIPQGGRGKFYHITVSSSQPNSSNDNIQSITSGDWDVTKILAYDEKGNKIYFLSTEDLPRRRQLYSANTVGNFNRQCLS
CDLVENCTYFSASFSHSMDFFLLKCEGPGVPMVTVHNTTDKKKMFDLETNEHVKKAINDRQMPKVEYRDIEIDDYNLPMQILKPATFTDT
THYPLLLVVDGTPGSQSVAEKFEVSWETVMVSSHGAVVVKCDGRGSGFQGTKLLHEVRRRLGLLEEKDQMEAVRTMLKEQYIDRTRVAVF
GKDYGGYLSTYILPAKGENQGQTFTCGSALSPITDFKLYASAFSERYLGLHGLDNRAYEMTKVAHRVSALEEQQFLIIHPTADEKIHFQH

--------------------------------------------------------------
>2192_2192_2_ADCK2-DPP6_ADCK2_chr7_140390613_ENST00000476491_DPP6_chr7_154429531_ENST00000404039_length(transcript)=5694nt_BP=1918nt
GGCGCGGGCCTCCGGCCTGAGGCCCGGCGAGGTGCTGGAGGGAGCGGGGCGCGGATCCGGCCCAGATGGGCAGCTCCGTCCGCGGGGTCA
GGGCCGGGCTTCGGCTTCACCGCAGCCTCGCCTGAGCGGGCGCCTCTGAAGTGGAGGGCGGGCCGCCTGGGCCGCGGGCCTCGGGAGGAT
GGTGGCGCCCTGGCGCGTCTCCGTCAGGGTTTGCCTGTCGCACCTGAGGTGCTTCGAGCTCAGACAGGGACTCAGCCTCCTGAGGCCCTC
CGAGTGCCCTCGCGATGCCAGGCTCTGCTGGCTTCTGCTGGGCACTTTGCCCAAGGTCGTCTCCCTGTGCGGGGACGTGGGTGAGGGGGC
CCCTGACGTTCTGAGTCGGCGAAGGGTCCGCTGCAGCGGGGCGGCTGGCGCGGGGCCCGCGGAGAGCCTCCCCCGAGCGGGACCTCTGGG
CGGCGTCTTCCTGCATCTCCGCCTCTGGCTTCGCGCCGGCGCTCTGTTGGTGAAATTCTTCCCCCTCCTACTCCTCTACCCCCTCACCTA
CCTGGCTCCCAGCGTCTCCACCCTCTGGCTCCACCTGCTTCTGAAAGCCACCGAGACCTCAGGCCCAACCTACATCAAACTGGGCCAGTG
GGCCAGCACCCGGCGCGATCTGTTTTCGGAGGCTTTCTGTGCCCAATTTTCCAAGCTGCATGTCCGAGTGACGCCCCACCCGTGGACTCA
CACTGAGCGCTTCCTTCGGCAGGCTTTTGGGGATGACTGGGGGAGCATCCTCTCTTTTGAGAACCGGGAACCTGTGGGCTCAGGCTGCGT
GGCCCAGGTGTACAAAGCATACGCCAACACTGCCTTCCTGGAGACTGACAGCGTCCAGAGACTTGGCAGGGCCTCCTGTCTGCCGCCCTT
CTCACATACTGGGGCAGTCGGTGGGCTGAGAGAGCTCTTTGGATACCTTGGAAATGGCCGGAAACCTCCAGAAAATCTCGCAGACCAGTC
GTTTCTAGAAAGGCTGCTCCTCCCTAAAGCTGACCTGGTTGGATCAAATGCAGGGGTGTCTCGGGCTCAGGTCCCTGGCCACCAACCTGA
GGCCACCAACCTCATCTCCGTGGCAGTGAAAGTGTTGCACCCTGGCCTGCTCGCTCAGGTGCATATGGACCTGCTGCTGATGAAGATTGG
CAGCCGAGTCCTGGGAGTTTTGCCAGGCATCAAGTGGCTTAGCTTGCCTGAGATTGTGGAGGAATTTGAGAAGCTGATGGTCCAACAGAT
TGACCTGCGTTACGAAGCTCAGAATCTAGAACACTTCCAGGTCAACTTCCGGAATGTGAAAGCCGTCAAGTTCCCCACCCCTCTGCGCCC
CTTTGTCACCAGAGAAGTCTTGGTGGAAACGTATGAAGAGAGTGTGCCTGTGTCCAGTTACCAGCAGGCAGGAATTCCCGTGGACTTGAA
AAGGAAGATTGCACGGCTGGGGATCAACATGCTCCTGAAGATGATATTTGTGGATAACTTTGTCCATGCAGACCTTCACCCTGGAAACAT
CCTGGTTCAGGGTGCCAACGGCCTGTCCTCGAGTCAGGAGGCGCAGCTGCAGCAGGCGGACATCTGTGACACTCTGGTGGTGGCCGTGCC
ATCTTCCCTCTGCCCGCTGCGACTGGTGCTGCTGGATGCTGGCATTGTGGCGGAGCTGCAGGCCCCTGACCTGAGGAATTTCCGGGCAGT
TTTCATGGCTGTGGTGATGGGGCAGGGCCAGAGAGTGGCTGAGCTGATCCTGCATCATGCCCGGGCCAGCGAGTGCAGGGACGTGGAGGG
GTTCAAAACCGAGATGGCCATGCTGGTGACCCAGGCCAGGAAGAACACCATCACCCTGGAGAAGCTTCATGTGTCCAGCCTTCTCTCTAG
TGTCTTTAAGTTGCTGATGACTCACAAGATATATCAACACTCGTATACTGGATATTACGTCCTGAGCAAAATTCCTCATGGGGATCCTCA
AAGTCTGGACCCACCAGAAGTCAGCAATGCAAAACTTCAGTATGCAGGATGGGGCCCTAAAGGCCAACAGCTGATATTTATTTTTGAAAA
CAATATCTACTACTGTGCACATGTCGGGAAACAGGCCATCCGTGTGGTCTCCACTGGCAAGGAAGGTGTGATTTACAATGGCCTCAGTGA
CTGGCTGTATGAAGAGGAGATTTTGAAGACACACATCGCACACTGGTGGTCTCCGGATGGCACGAGACTCGCCTACGCCGCCATCAATGA
TTCCCGTGTCCCCATCATGGAGCTCCCAACTTACACCGGCTCCATCTACCCCACCGTGAAGCCCTACCACTATCCCAAGGCTGGAAGTGA
GAACCCCAGCATTTCCCTACACGTTATTGGCTTAAATGGACCCACCCATGATCTGGAGATGATGCCGCCTGATGATCCACGGATGAGGGA
GTACTACATCACCATGGTGAAGTGGGCCACCAGCACCAAGGTCGCCGTGACCTGGCTGAACCGGGCGCAGAACGTGTCCATCCTCACCCT
CTGCGACGCCACCACGGGGGTCTGCACGAAGAAACACGAGGATGAAAGTGAGGCCTGGCTCCACAGACAGAATGAAGAACCTGTGTTCTC
CAAGGATGGCCGAAAGTTTTTCTTCATCAGAGCCATCCCCCAGGGAGGACGAGGGAAATTCTATCACATCACGGTGTCCTCGTCCCAGCC
CAACAGCAGCAACGACAACATCCAGTCCATCACCTCCGGGGACTGGGACGTGACCAAGATCCTAGCCTACGATGAGAAGGGGAATAAGAT
CTACTTCCTGAGCACGGAGGACCTGCCTCGGAGACGACAACTCTACAGTGCCAACACGGTGGGCAACTTCAACAGGCAGTGCCTCTCCTG
TGACCTGGTTGAGAACTGCACCTACTTCAGCGCTTCCTTCAGCCATAGCATGGACTTCTTCCTGCTCAAGTGCGAAGGTCCTGGTGTTCC
TATGGTGACGGTGCACAACACAACAGATAAGAAAAAAATGTTTGACCTAGAAACAAATGAACATGTCAAGAAGGCCATAAATGACCGACA
GATGCCTAAAGTGGAATACAGGGACATTGAGATTGATGATTACAACCTGCCCATGCAGATACTGAAGCCAGCAACCTTCACCGACACCAC
CCACTACCCTCTGCTCCTGGTGGTGGATGGCACCCCAGGCAGCCAGAGTGTGGCTGAGAAGTTCGAGGTGAGCTGGGAGACGGTGATGGT
GAGCAGCCACGGCGCGGTGGTGGTAAAGTGTGACGGCCGTGGCAGCGGCTTCCAAGGGACCAAGCTCCTGCACGAAGTGAGGCGGCGGCT
GGGCTTGCTGGAGGAGAAGGACCAGATGGAGGCCGTGCGGACGATGCTGAAGGAGCAGTACATTGACAGGACGCGCGTGGCCGTGTTTGG
GAAGGATTACGGTGGCTACCTGAGCACCTACATCCTCCCAGCAAAGGGAGAAAATCAAGGCCAGACATTCACCTGCGGCTCTGCTCTCTC
TCCAATAACAGACTTCAAACTCTATGCCTCTGCGTTTTCCGAGAGGTACTTGGGCCTCCATGGACTTGACAACAGAGCATACGAGATGAC
CAAGGTAGCCCATCGAGTCTCCGCGCTGGAAGAACAGCAGTTCCTGATCATTCATCCCACTGCCGATGAAAAAATTCATTTCCAGCACAC
AGCAGAACTCATTACACAACTAATTAGGGGAAAGGCTAATTACAGCTTACAGATTTACCCGGACGAAAGCCATTACTTTACCAGCTCCAG
CCTCAAACAGCATCTGTACCGGTCCATCATCAACTTCTTCGTGGAATGCTTCAGGATCCAGGACAAACTGCTGACAGTCACAGCGAAAGA
GGACGAGGAGGAGGACTAAGCTCAGGTCGCTCTAAGCACAAACGTGGCTCTTTCTACAACCAGATGCAACCGAGGGATTTCCCTGCCCTC
CCTCTTCCCTCGGAGGGGCGGGGCGGGGCGGGGCCGGGTGTTCCATAGCATGTGTGTCTCGGATGCGGAAGGCAGTTTTGCTTGGGAAAC
AAGCTCCTTCCCCGGGGTCATCACTCACGGCCTCCATGGCACCAGGGACAACGCTGTCCCCGCAGCAGCGCCTCCTCCCGGCGCCCGAGA
GACCGGCACGCCACGGCCCCTCCCCCAAGGAACAGAGCAAAGGATGGTGGCCGCAGGCCCCACGCGAGCCCACAGGACACCGGCCCCTAG
ATTCCAGCCACCAAGCGGAAGCATGAGACCCGCCCACACTAGCCTCTGTGTTCCCGTTAGGGACATCACACCCTGTCTCACGTCGCAGTG
CCATGGACGCAGCAGTTACAGCACCATTGTTTTAGCAGTGCGTGTTCATATATGGGCTTGCTACTTCCTGTAATGAGGACGTTCAACATG
GTGAGGGGCTACAAGAAAACGCTTTTCTGTACAGAGTCTTACTGTAGCTACGCTAATGGTTAACCTGATAGAATTAACTCGTATTTTTCT
ATGGTTTTAACCTGATGCTCCACTGTCTCCGTCATGGGGTTGTTTTGCTGTTTGGGGTTGGGCCTTGTTTCCCTTTCCTTTCTCCAGTCC
ACGTGTAGACTTTGCGCTTGATGAAGAAGCAGATCGGAAGTAACTGCTCCCTCCTCAAGGTTGTCTTCAGACGTCTTGGGGACGTTCCTA
AACACTGAGGGGGAAGACAGCCAATAGCACCCATTAAAAGAAATACCTAAATAAAACCTCTCTCCCACTCAGCTATGCTAGGGCTTGGCT
GTAGGTGTGCACTGTCTATTTACATCCGTCCTTACAACCATCCTTGTCCTCCTTGGTACCGTATCAAGCTCTTTCCCATGACATTTGGTT
TAAAAAAAAAAAAAAAAAAAAAAAAAAAACAGAAAAAAGACAAAGCGTCAACTCCACCCACAGGCCCGCTGTGTGTGCTCGGGCCACGGG
AGTCCTGAGGGTTCTGTGGGCCTGCGCGCATCCCTCTCCCATCGTGGGGGTGGCTCCGTGACCTTCCTGCCACGAGCAGGAGGTTGATGA
TGTGCTACGTTAGCCTTGTAAGATACACCCCCACCAAATGTGCAGCCGGTGTTCCCAGTGTATATTTCATTCTCTTGTATATAAAGGAAG
CAATGTGTGTCAGGCCTCTGTGCAGTCAACCCAGCCTCCTCCCGCCAGTGCTAACCCCGTGTTGAGCCTGCATGCTGACACTGTGGCCGA
TCTGGACTCTAGAAGTGCTAGTTTGAAATATATCCATTACTGTCATTTCCTTTTGAGCTTGTGGACAAGCTGAATGTCAGGACTGACTTC
GCCAGCTCCCAGCCCTGCGGGGGTGTCCTTGGCATCCCATCAGCAGAGGAGATGCGTCCCTGTTGCATTTTGGCGTTTGGGGCTTTGGGT
TTATCCACATGAGCTCTGAACGTCCGTTATAGTTAGGGTGATTGGAAGGTCTCCATCACTGGGTGTTTTAAAGGTGATTCACCACCATTT
GTGAAAGGACCAACGTGCTGATAAACAGGACCGATCCGAGTGCTACATGACTGTGCGTTTGCTATTTCAATGGGCCTGAACGACTACAAA
GCCAGCTAGGTCTGGAAGGGGAAGCCAGCTCTGGCCACGACATCTGGTCGGAGGGAAGTGGGGATGTGGCATGGTAGCGTCTGTTCATCC

>2192_2192_2_ADCK2-DPP6_ADCK2_chr7_140390613_ENST00000476491_DPP6_chr7_154429531_ENST00000404039_length(amino acids)=1236AA_BP=580
MVAPWRVSVRVCLSHLRCFELRQGLSLLRPSECPRDARLCWLLLGTLPKVVSLCGDVGEGAPDVLSRRRVRCSGAAGAGPAESLPRAGPL
GGVFLHLRLWLRAGALLVKFFPLLLLYPLTYLAPSVSTLWLHLLLKATETSGPTYIKLGQWASTRRDLFSEAFCAQFSKLHVRVTPHPWT
HTERFLRQAFGDDWGSILSFENREPVGSGCVAQVYKAYANTAFLETDSVQRLGRASCLPPFSHTGAVGGLRELFGYLGNGRKPPENLADQ
SFLERLLLPKADLVGSNAGVSRAQVPGHQPEATNLISVAVKVLHPGLLAQVHMDLLLMKIGSRVLGVLPGIKWLSLPEIVEEFEKLMVQQ
IDLRYEAQNLEHFQVNFRNVKAVKFPTPLRPFVTREVLVETYEESVPVSSYQQAGIPVDLKRKIARLGINMLLKMIFVDNFVHADLHPGN
ILVQGANGLSSSQEAQLQQADICDTLVVAVPSSLCPLRLVLLDAGIVAELQAPDLRNFRAVFMAVVMGQGQRVAELILHHARASECRDVE
GFKTEMAMLVTQARKNTITLEKLHVSSLLSSVFKLLMTHKIYQHSYTGYYVLSKIPHGDPQSLDPPEVSNAKLQYAGWGPKGQQLIFIFE
NNIYYCAHVGKQAIRVVSTGKEGVIYNGLSDWLYEEEILKTHIAHWWSPDGTRLAYAAINDSRVPIMELPTYTGSIYPTVKPYHYPKAGS
ENPSISLHVIGLNGPTHDLEMMPPDDPRMREYYITMVKWATSTKVAVTWLNRAQNVSILTLCDATTGVCTKKHEDESEAWLHRQNEEPVF
SKDGRKFFFIRAIPQGGRGKFYHITVSSSQPNSSNDNIQSITSGDWDVTKILAYDEKGNKIYFLSTEDLPRRRQLYSANTVGNFNRQCLS
CDLVENCTYFSASFSHSMDFFLLKCEGPGVPMVTVHNTTDKKKMFDLETNEHVKKAINDRQMPKVEYRDIEIDDYNLPMQILKPATFTDT
THYPLLLVVDGTPGSQSVAEKFEVSWETVMVSSHGAVVVKCDGRGSGFQGTKLLHEVRRRLGLLEEKDQMEAVRTMLKEQYIDRTRVAVF
GKDYGGYLSTYILPAKGENQGQTFTCGSALSPITDFKLYASAFSERYLGLHGLDNRAYEMTKVAHRVSALEEQQFLIIHPTADEKIHFQH

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Fusion Gene PPI Analysis for ADCK2-DPP6


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ADCK2-DPP6


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ADCK2-DPP6


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC1510586Autism Spectrum Disorders2CTD_human
TgeneC2751898Ventricular Fibrillation, Paroxysmal Familial, 12ORPHANET
TgeneC4017668VENTRICULAR FIBRILLATION DURING MYOCARDIAL INFARCTION, SUSCEPTIBILITY TO2ORPHANET
TgeneC0002736Amyotrophic Lateral Sclerosis1CTD_human
TgeneC0220693Microcephaly autosomal dominant1ORPHANET
TgeneC0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
TgeneC0431350Primary microcephaly1GENOMICS_ENGLAND
TgeneC0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human
TgeneC4225375MENTAL RETARDATION, AUTOSOMAL DOMINANT 331CTD_human;GENOMICS_ENGLAND;UNIPROT