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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:L3MBTL4-TRDMT1 (FusionGDB2 ID:HG91133TG1787)

Fusion Gene Summary for L3MBTL4-TRDMT1

check button Fusion gene summary
Fusion gene informationFusion gene name: L3MBTL4-TRDMT1
Fusion gene ID: hg91133tg1787
HgeneTgene
Gene symbol

L3MBTL4

TRDMT1

Gene ID

91133

1787

Gene nameL3MBTL histone methyl-lysine binding protein 4tRNA aspartic acid methyltransferase 1
SynonymsHsT1031DMNT2|DNMT2|MHSAIIP|PUMET|RNMT1
Cytomap('L3MBTL4')('TRDMT1')

18p11.31

10p13

Type of geneprotein-codingprotein-coding
Descriptionlethal(3)malignant brain tumor-like protein 4H-l(3)mbt-like protein 4L3MBTL4, histone methyl-lysine binding proteintRNA (cytosine(38)-C(5))-methyltransferaseDNA (cytosine-5)-methyltransferase-like protein 2DNA MTase homolog HsaIIPDNA cytosine-5 methyltransferase 2DNA methyltransferase-2tRNA (cytosine-5-)-methyltransferase
Modification date2020031320200313
UniProtAcc

Q8NA19

.
Ensembl transtripts involved in fusion geneENST00000284898, ENST00000317931, 
ENST00000400104, ENST00000400105, 
ENST00000535782, ENST00000578677, 
Fusion gene scores* DoF score8 X 8 X 4=2563 X 3 X 2=18
# samples 83
** MAII scorelog2(8/256*10)=-1.67807190511264
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: L3MBTL4 [Title/Abstract] AND TRDMT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointL3MBTL4(6237963)-TRDMT1(17216659), # samples:2
Anticipated loss of major functional domain due to fusion event.L3MBTL4-TRDMT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
L3MBTL4-TRDMT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
L3MBTL4-TRDMT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
L3MBTL4-TRDMT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
L3MBTL4-TRDMT1 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
L3MBTL4-TRDMT1 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
L3MBTL4-TRDMT1 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
L3MBTL4-TRDMT1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneTRDMT1

GO:0030488

tRNA methylation

16424344


check buttonFusion gene breakpoints across L3MBTL4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TRDMT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-ZF-AA4T-01AL3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-


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Fusion Gene ORF analysis for L3MBTL4-TRDMT1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000284898ENST00000457442L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
5CDS-5UTRENST00000317931ENST00000457442L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
5CDS-5UTRENST00000400104ENST00000457442L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
5CDS-5UTRENST00000400105ENST00000457442L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
5CDS-5UTRENST00000535782ENST00000457442L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
5CDS-intronENST00000284898ENST00000452380L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
5CDS-intronENST00000284898ENST00000488990L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
5CDS-intronENST00000317931ENST00000452380L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
5CDS-intronENST00000317931ENST00000488990L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
5CDS-intronENST00000400104ENST00000452380L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
5CDS-intronENST00000400104ENST00000488990L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
5CDS-intronENST00000400105ENST00000452380L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
5CDS-intronENST00000400105ENST00000488990L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
5CDS-intronENST00000535782ENST00000452380L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
5CDS-intronENST00000535782ENST00000488990L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
Frame-shiftENST00000284898ENST00000351358L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
Frame-shiftENST00000284898ENST00000358282L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
Frame-shiftENST00000284898ENST00000377766L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
Frame-shiftENST00000284898ENST00000377799L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
Frame-shiftENST00000284898ENST00000412821L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
Frame-shiftENST00000317931ENST00000351358L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
Frame-shiftENST00000317931ENST00000358282L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
Frame-shiftENST00000317931ENST00000377766L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
Frame-shiftENST00000317931ENST00000377799L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
Frame-shiftENST00000317931ENST00000412821L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
Frame-shiftENST00000400104ENST00000351358L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
Frame-shiftENST00000400104ENST00000358282L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
Frame-shiftENST00000400104ENST00000377766L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
Frame-shiftENST00000400104ENST00000377799L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
Frame-shiftENST00000400104ENST00000412821L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
Frame-shiftENST00000400105ENST00000351358L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
Frame-shiftENST00000400105ENST00000358282L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
Frame-shiftENST00000400105ENST00000377766L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
Frame-shiftENST00000400105ENST00000377799L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
Frame-shiftENST00000400105ENST00000412821L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
Frame-shiftENST00000535782ENST00000358282L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
Frame-shiftENST00000535782ENST00000377766L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
In-frameENST00000535782ENST00000351358L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
In-frameENST00000535782ENST00000377799L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
In-frameENST00000535782ENST00000412821L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
intron-3CDSENST00000578677ENST00000351358L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
intron-3CDSENST00000578677ENST00000358282L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
intron-3CDSENST00000578677ENST00000377766L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
intron-3CDSENST00000578677ENST00000377799L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
intron-3CDSENST00000578677ENST00000412821L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
intron-5UTRENST00000578677ENST00000457442L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
intron-intronENST00000578677ENST00000452380L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-
intron-intronENST00000578677ENST00000488990L3MBTL4chr18

6237963

-TRDMT1chr10

17216659

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000535782L3MBTL4chr186237963-ENST00000377799TRDMT1chr1017216659-368927401385461
ENST00000535782L3MBTL4chr186237963-ENST00000412821TRDMT1chr1017216659-147727401313437
ENST00000535782L3MBTL4chr186237963-ENST00000351358TRDMT1chr1017216659-141127401247415

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000535782ENST00000377799L3MBTL4chr186237963-TRDMT1chr1017216659-0.0001526850.9998473
ENST00000535782ENST00000412821L3MBTL4chr186237963-TRDMT1chr1017216659-0.0003523080.99964774
ENST00000535782ENST00000351358L3MBTL4chr186237963-TRDMT1chr1017216659-0.0002278110.99977225

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Fusion Genomic Features for L3MBTL4-TRDMT1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for L3MBTL4-TRDMT1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr18:6237963/chr10:17216659)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
L3MBTL4

Q8NA19

.
FUNCTION: Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneL3MBTL4chr18:6237963chr10:17216659ENST00000284898-1020160_260261624.0RepeatNote=MBT 2
HgeneL3MBTL4chr18:6237963chr10:17216659ENST00000284898-102052_152261624.0RepeatNote=MBT 1
HgeneL3MBTL4chr18:6237963chr10:17216659ENST00000400104-1017160_260261535.0RepeatNote=MBT 2
HgeneL3MBTL4chr18:6237963chr10:17216659ENST00000400104-101752_152261535.0RepeatNote=MBT 1
HgeneL3MBTL4chr18:6237963chr10:17216659ENST00000400105-1020160_260261624.0RepeatNote=MBT 2
HgeneL3MBTL4chr18:6237963chr10:17216659ENST00000400105-102052_152261624.0RepeatNote=MBT 1
TgeneTRDMT1chr18:6237963chr10:17216659ENST000003513580957_5821346.0RegionS-adenosyl-L-methionine binding
TgeneTRDMT1chr18:6237963chr10:17216659ENST000003582820957_5821143.0RegionS-adenosyl-L-methionine binding
TgeneTRDMT1chr18:6237963chr10:17216659ENST0000037779901157_5821392.0RegionS-adenosyl-L-methionine binding
TgeneTRDMT1chr18:6237963chr10:17216659ENST0000041282101057_5821368.0RegionS-adenosyl-L-methionine binding

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneL3MBTL4chr18:6237963chr10:17216659ENST00000284898-1020543_607261624.0DomainSAM
HgeneL3MBTL4chr18:6237963chr10:17216659ENST00000400104-1017543_607261535.0DomainSAM
HgeneL3MBTL4chr18:6237963chr10:17216659ENST00000400105-1020543_607261624.0DomainSAM
HgeneL3MBTL4chr18:6237963chr10:17216659ENST00000284898-1020269_364261624.0RepeatNote=MBT 3
HgeneL3MBTL4chr18:6237963chr10:17216659ENST00000400104-1017269_364261535.0RepeatNote=MBT 3
HgeneL3MBTL4chr18:6237963chr10:17216659ENST00000400105-1020269_364261624.0RepeatNote=MBT 3
HgeneL3MBTL4chr18:6237963chr10:17216659ENST00000284898-1020370_414261624.0Zinc fingerCCHHC-type
HgeneL3MBTL4chr18:6237963chr10:17216659ENST00000400104-1017370_414261535.0Zinc fingerCCHHC-type
HgeneL3MBTL4chr18:6237963chr10:17216659ENST00000400105-1020370_414261624.0Zinc fingerCCHHC-type
TgeneTRDMT1chr18:6237963chr10:17216659ENST00000351358094_39121346.0DomainSAM-dependent MTase C5-type
TgeneTRDMT1chr18:6237963chr10:17216659ENST00000358282094_39121143.0DomainSAM-dependent MTase C5-type
TgeneTRDMT1chr18:6237963chr10:17216659ENST000003777990114_39121392.0DomainSAM-dependent MTase C5-type
TgeneTRDMT1chr18:6237963chr10:17216659ENST000004128210104_39121368.0DomainSAM-dependent MTase C5-type
TgeneTRDMT1chr18:6237963chr10:17216659ENST000003513580913_1521346.0RegionS-adenosyl-L-methionine binding
TgeneTRDMT1chr18:6237963chr10:17216659ENST000003582820913_1521143.0RegionS-adenosyl-L-methionine binding
TgeneTRDMT1chr18:6237963chr10:17216659ENST0000037779901113_1521392.0RegionS-adenosyl-L-methionine binding
TgeneTRDMT1chr18:6237963chr10:17216659ENST0000041282101013_1521368.0RegionS-adenosyl-L-methionine binding


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Fusion Gene Sequence for L3MBTL4-TRDMT1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>43810_43810_1_L3MBTL4-TRDMT1_L3MBTL4_chr18_6237963_ENST00000535782_TRDMT1_chr10_17216659_ENST00000351358_length(transcript)=1411nt_BP=274nt
TTGCAAAATGCTCCAAAGAAATTATTCAGAAACAGAAGTCCTAATGGGCCAATGTCTAAAGAATTTCAGGTTGGAATGAAGCTGGAGGCC
GTGGACAGGAAGAACCCTTCCTTGGTGTGTGTGGCGACCATAGCAGATATTGTTGAAGATCGCTTACTAGTGCATTTTGACAACTGGGAT
GATAGTTACGATTACTGGTGCGATGTTAATAGCCCTTATGTCCAGCCAGTTGGTTGGTGTCAGGAGAATGGAAGAACTCTGATAGCACCC
CAAGAAAGCTGTATACCTGCACAAGTGGTGGCTGCCATTGATGTCAACACTGTCGCTAATGAAGTATACAAGTATAATTTTCCTCACACA
CAGTTACTTGCCAAGACGATTGAAGGCATTACACTCGAAGAGTTTGACAGATTATCTTTTGATATGATTTTAATGAGCCCTCCCTGCCAG
CCATTCACAAGAGACCTCTTGATACAAACAATAGAAAATTGTGGCTTTCAGTACCAAGAGTTTCTATTATCTCCAACCTCTCTTGGCATT
CCAAATTCAAGGCTACGATATTTTCTTATTGCAAAGCTTCAGTCAGAGCCATTACCCTTTCAAGCCCCTGGTCAGGTACTGATGGAGTTC
CCCAAAATTGAATCTGTACATCCACAAAAATATGCAATGGATGTAGAAAATAAAATTCAAGAAAAGAACGTTGAACCAAATATTAGCTTT
GATGGCAGCATACAGTGTTCTGGAAAAGATGCCATTCTTTTTAAGCTTGAAACTGCAGAAGAAATTCACAGGAAAAATCAACAAGATAGT
GATCTCTCTGTGAAAATGCTAAAAGATTTTCTTGAAGATGACACTGACGTGAACCAGTATCTTTTACCACCAAAGTCATTGCTGCGATAT
GCTCTTCTGTTAGACATTGTTCAGCCCACTTGTAGAAGGTCCGTGTGCTTTACCAAAGGATATGGAAGCTACATAGAAGGGACAGGGTCT
GTGTTACAGACTGCAGAGGATGTGCAGGTTGAGAATATCTACAAATCCCTTACCAATTTGTCACAAGAAGAACAGATAACAAAGCTGTTA
ATACTTAAACTGCGATATTTCACTCCTAAAGAAATAGCAAATCTCCTTGGATTTCCTCCAGAGTTCGGATTTCCTGAGAAGATAACAGTG
AAACAGCGTTATCGCCTACTTGGAAATAGTCTCAACGTGCATGTAGTAGCTAAACTAATCAAAATCTTATATGAATAATTTTGAAATAAC
TCTGAAAGATGGTCATATGATATTCCTTCATTTTCAGAGAGTAATTCTGAAATTCTGTTTTGAACTAATTCTGGTGAAATTTAACTAAAT
TATTTTAATCTGTCCTTATTAAGAAATTTGGATTTTATTAAAAAAATCCATGTGTTTCATC

>43810_43810_1_L3MBTL4-TRDMT1_L3MBTL4_chr18_6237963_ENST00000535782_TRDMT1_chr10_17216659_ENST00000351358_length(amino acids)=415AA_BP=91
LQNAPKKLFRNRSPNGPMSKEFQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNWDDSYDYWCDVNSPYVQPVGWCQENGRTLIAP
QESCIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFDMILMSPPCQPFTRDLLIQTIENCGFQYQEFLLSPTSLGI
PNSRLRYFLIAKLQSEPLPFQAPGQVLMEFPKIESVHPQKYAMDVENKIQEKNVEPNISFDGSIQCSGKDAILFKLETAEEIHRKNQQDS
DLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSYIEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLL
ILKLRYFTPKEIANLLGFPPEFGFPEKITVKQRYRLLGNSLNVHVVAKLIKILYE

--------------------------------------------------------------
>43810_43810_2_L3MBTL4-TRDMT1_L3MBTL4_chr18_6237963_ENST00000535782_TRDMT1_chr10_17216659_ENST00000377799_length(transcript)=3689nt_BP=274nt
TTGCAAAATGCTCCAAAGAAATTATTCAGAAACAGAAGTCCTAATGGGCCAATGTCTAAAGAATTTCAGGTTGGAATGAAGCTGGAGGCC
GTGGACAGGAAGAACCCTTCCTTGGTGTGTGTGGCGACCATAGCAGATATTGTTGAAGATCGCTTACTAGTGCATTTTGACAACTGGGAT
GATAGTTACGATTACTGGTGCGATGTTAATAGCCCTTATGTCCAGCCAGTTGGTTGGTGTCAGGAGAATGGAAGAACTCTGATAGCACCC
CAAGAAAGCTGTATACCTGCACAAGTGGTGGCTGCCATTGATGTCAACACTGTCGCTAATGAAGTATACAAGTATAATTTTCCTCACACA
CAGTTACTTGCCAAGACGATTGAAGGCATTACACTCGAAGAGTTTGACAGATTATCTTTTGATATGATTTTAATGAGCCCTCCCTGCCAG
CCATTCACAAGGATTGGCCGGCAGGGTGATATGACTGATTCAAGGACGAATAGCTTCTTACATATTCTAGATATTCTCCCAAGATTACAA
AAATTACCAAAGTATATTCTTTTGGAAAATGTTAAAGGTTTTGAAGTATCTTCTACAAGAGACCTCTTGATACAAACAATAGAAAATTGT
GGCTTTCAGTACCAAGAGTTTCTATTATCTCCAACCTCTCTTGGCATTCCAAATTCAAGGCTACGATATTTTCTTATTGCAAAGCTTCAG
TCAGAGCCATTACCCTTTCAAGCCCCTGGTCAGGTACTGATGGAGTTCCCCAAAATTGAATCTGTACATCCACAAAAATATGCAATGGAT
GTAGAAAATAAAATTCAAGAAAAGAACGTTGAACCAAATATTAGCTTTGATGGCAGCATACAGTGTTCTGGAAAAGATGCCATTCTTTTT
AAGCTTGAAACTGCAGAAGAAATTCACAGGAAAAATCAACAAGATAGTGATCTCTCTGTGAAAATGCTAAAAGATTTTCTTGAAGATGAC
ACTGACGTGAACCAGTATCTTTTACCACCAAAGTCATTGCTGCGATATGCTCTTCTGTTAGACATTGTTCAGCCCACTTGTAGAAGGTCC
GTGTGCTTTACCAAAGGATATGGAAGCTACATAGAAGGGACAGGGTCTGTGTTACAGACTGCAGAGGATGTGCAGGTTGAGAATATCTAC
AAATCCCTTACCAATTTGTCACAAGAAGAACAGATAACAAAGCTGTTAATACTTAAACTGCGATATTTCACTCCTAAAGAAATAGCAAAT
CTCCTTGGATTTCCTCCAGAGTTCGGATTTCCTGAGAAGATAACAGTGAAACAGCGTTATCGCCTACTTGGAAATAGTCTCAACGTGCAT
GTAGTAGCTAAACTAATCAAAATCTTATATGAATAATTTTGAAATAACTCTGAAAGATGGTCATATGATATTCCTTCATTTTCAGAGAGT
AATTCTGAAATTCTGTTTTGAACTAATTCTGGTGAAATTTAACTAAATTATTTTAATCTGTCCTTATTAAGAAATTTGGATTTTATTAAA
AAAATCCATGTGTTTCATCAAATTTATATTACTGTATTTTATAAAATACGAACTATTGTTATGCTTTATGGAGAGTATATTTTCATATGA
AACTGATAAATATATATGTGGAATATTCTTTTTAAAAACAATTTTATAAACAAATCAAGGAGCACTAGAGCTTTAGTGTCTACATGAGTA
TCTTGTGAAGTGTCATAACAGGCATAACATATTTTTATGTTAATTAAAGAAGTTTTTTATTTCTAATTTTAAAATAATGATTCTAATTCT
AGCCCATTGAATGTTTTACTTAATTTCCAATCCTGTAAATATTTCTTTATTTCATCTAAACAAATGCATATGATATGTAAACCAAATTAT
CATCATTCAGTTTATACAGCAGACTGAAGAATATGTCAGGAAAAATAATCCTAAATGTTTGATTACCTCTCCATGAAGCGGCCACAGAAA
CTGTTGGTGCACATTATCTACATTTTCCTCAGCCTCTATCTGAAGGACAAAACTCATTTTTCCTTCTTCATTTTGTATGTACTTTCCTTT
AGTTGACTATTATCAAAGCTTGTTTTTGTCTTCTCAGCTTCTGAGTTGAATTTGCCTTTGCACGCTGAGGAATGTAGCATGACGTTAAGA
TTTCAGGGAGGAAGCTGCCCTCTGATCCCATGTCATATGACAGTACTCCCCTCCCCCCAGTTGTTCTTTATTGTAGCAACATACACTCTC
AATGAACTTTTATGACTTTTAACTTTCTCTGTCTCTCTTCCTCAGCAGACCTCTTGGAATTAGGGTTTCTAATCAAACTAAGTCTTGCAT
CATAAATTCTATGGTTTGTGATAAAAGCAAGTGACAAAGAGAAGAGAGATGAAAAGAAACAAGTCCAGAAATCATATTACAAGATTTTAA
TTCAAATTTTTCTTCTTAAAAATCAGCTATTTAGAGGTGGATAAATTGGAAGTTTGTGCATTGCTTGTGGGAACGTAAAATGGTTCAGCT
GCTGTTGGAAAACGCTATGGAGGTTCGTCACAAAATTCAACATAGAATTACCCTATGATTCAGCGATTCCACCTCTGGCTATAGATCCAA
AAGAATTGAAAGCAGGGACTTGAACAGATATTTGTACACCAGCGTTTATAACACCATTATTTACAGTAGCCAAAAGGTAGAAGCAGCCCA
AGTGTCATCCCATTCACCCATGAATGGATGCAGGAATTGTGTTCCGTGCATGCAGTGGAATAGTACCAGCCTTCCGCAGGAAGGAAATTC
TGACATATGCGGTGACATGGATGAACCTTGAGTACATTATGCGAAGTGAAATAAGCCACCCTGTGGGGATGGAGAATGGGTAGTTAGTGC
ATAATGGATACAAAGTTTCTGATTGGGGTGATGAGAAAGTTCTGGAGGTGGATGGGGAGGATGGTTGCACAACAGTGTGAGTGTACTTAA
TGCCACTGCAACTGTATATTTAAAAATAGTTAAAATGATAAATTTTACATTATGTATATTTTACTGCAATTGAAAAAATCATACTCTATT
ACCAATTTTTCAGAACTCATAGATAAATATGAATGTAGGGAAGCTGTAAGCCAGCCCATATACAGAAACTATCACTATCTACATTTTTCA
TATGTGTTCAGACAGAGCCTATTACAAGTCTCATAAATTTCAGTAAACAATCACAAATTATTTTGGCACACTTTCATGTAGGTTCTGTTC
ACTGCTGAAATATTCTAAATAAAATGGTTTAGAGTTTTACTGTAACTATGAATAATTATGCTATAATTATAGTATCCCACATTCGGTTGA
GCAACATTATACAAAATAAGTGTCGAGTTACTGTGCACCAACTATAAATACTTGAAAGGTCTGTAGAGACATTTGCTTACAAACTGGTAG
ACAGAATGTAGCTTAGTGGAATTCTTAAATTATGGGAATGTATTCACAGGAAGACGGTGATTCTTGCCCTTAATTCATAATTGAAAATAT
GCAGTAACAAGCATAAAACTCACATCTTAATGAAGATGTATCTACCAGTGTCATTCAATTAGCAGATGTATATGTATGCATAATTAATTT
GGAAAATGTTATTTTATGGAATGTCTGCTATATGCTTTTGGTAATAATGCTGTATATAAAATTTGCACTGGAAATTCTGTTTCCTGATA

>43810_43810_2_L3MBTL4-TRDMT1_L3MBTL4_chr18_6237963_ENST00000535782_TRDMT1_chr10_17216659_ENST00000377799_length(amino acids)=461AA_BP=91
LQNAPKKLFRNRSPNGPMSKEFQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNWDDSYDYWCDVNSPYVQPVGWCQENGRTLIAP
QESCIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFDMILMSPPCQPFTRIGRQGDMTDSRTNSFLHILDILPRLQ
KLPKYILLENVKGFEVSSTRDLLIQTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPGQVLMEFPKIESVHPQKYAMD
VENKIQEKNVEPNISFDGSIQCSGKDAILFKLETAEEIHRKNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRS
VCFTKGYGSYIEGTGSVLQTAEDVQVENIYKSLTNLSQEEQITKLLILKLRYFTPKEIANLLGFPPEFGFPEKITVKQRYRLLGNSLNVH
VVAKLIKILYE

--------------------------------------------------------------
>43810_43810_3_L3MBTL4-TRDMT1_L3MBTL4_chr18_6237963_ENST00000535782_TRDMT1_chr10_17216659_ENST00000412821_length(transcript)=1477nt_BP=274nt
TTGCAAAATGCTCCAAAGAAATTATTCAGAAACAGAAGTCCTAATGGGCCAATGTCTAAAGAATTTCAGGTTGGAATGAAGCTGGAGGCC
GTGGACAGGAAGAACCCTTCCTTGGTGTGTGTGGCGACCATAGCAGATATTGTTGAAGATCGCTTACTAGTGCATTTTGACAACTGGGAT
GATAGTTACGATTACTGGTGCGATGTTAATAGCCCTTATGTCCAGCCAGTTGGTTGGTGTCAGGAGAATGGAAGAACTCTGATAGCACCC
CAAGAAAGCTGTATACCTGCACAAGTGGTGGCTGCCATTGATGTCAACACTGTCGCTAATGAAGTATACAAGTATAATTTTCCTCACACA
CAGTTACTTGCCAAGACGATTGAAGGCATTACACTCGAAGAGTTTGACAGATTATCTTTTGATATGATTTTAATGAGCCCTCCCTGCCAG
CCATTCACAAGATTACAAAAATTACCAAAGTATATTCTTTTGGAAAATGTTAAAGGTTTTGAAGTATCTTCTACAAGAGACCTCTTGATA
CAAACAATAGAAAATTGTGGCTTTCAGTACCAAGAGTTTCTATTATCTCCAACCTCTCTTGGCATTCCAAATTCAAGGCTACGATATTTT
CTTATTGCAAAGCTTCAGTCAGAGCCATTACCCTTTCAAGCCCCTGGTCAGGTACTGATGGAGTTCCCCAAAATTGAATCTGTACATCCA
CAAAAATATGCAATGGATGTAGAAAATAAAATTCAAGAAAAGAACGTTGAACCAAATATTAGCTTTGATGGCAGCATACAGTGTTCTGGA
AAAGATGCCATTCTTTTTAAGCTTGAAACTGCAGAAGAAATTCACAGGAAAAATCAACAAGATAGTGATCTCTCTGTGAAAATGCTAAAA
GATTTTCTTGAAGATGACACTGACGTGAACCAGTATCTTTTACCACCAAAGTCATTGCTGCGATATGCTCTTCTGTTAGACATTGTTCAG
CCCACTTGTAGAAGGTCCGTGTGCTTTACCAAAGGATATGGAAGCTACATAGAAGGGACAGGGTCTGTGTTACAGACTGCAGAGGATGTG
CAGGTTGAGAATATCTACAAATCCCTTACCAATTTGTCACAAGAAGAACAGATAACAAAGCTGTTAATACTTAAACTGCGATATTTCACT
CCTAAAGAAATAGCAAATCTCCTTGGATTTCCTCCAGAGTTCGGATTTCCTGAGAAGATAACAGTGAAACAGCGTTATCGCCTACTTGGA
AATAGTCTCAACGTGCATGTAGTAGCTAAACTAATCAAAATCTTATATGAATAATTTTGAAATAACTCTGAAAGATGGTCATATGATATT
CCTTCATTTTCAGAGAGTAATTCTGAAATTCTGTTTTGAACTAATTCTGGTGAAATTTAACTAAATTATTTTAATCTGTCCTTATTAAGA
AATTTGGATTTTATTAAAAAAATCCATGTGTTTCATC

>43810_43810_3_L3MBTL4-TRDMT1_L3MBTL4_chr18_6237963_ENST00000535782_TRDMT1_chr10_17216659_ENST00000412821_length(amino acids)=437AA_BP=91
LQNAPKKLFRNRSPNGPMSKEFQVGMKLEAVDRKNPSLVCVATIADIVEDRLLVHFDNWDDSYDYWCDVNSPYVQPVGWCQENGRTLIAP
QESCIPAQVVAAIDVNTVANEVYKYNFPHTQLLAKTIEGITLEEFDRLSFDMILMSPPCQPFTRLQKLPKYILLENVKGFEVSSTRDLLI
QTIENCGFQYQEFLLSPTSLGIPNSRLRYFLIAKLQSEPLPFQAPGQVLMEFPKIESVHPQKYAMDVENKIQEKNVEPNISFDGSIQCSG
KDAILFKLETAEEIHRKNQQDSDLSVKMLKDFLEDDTDVNQYLLPPKSLLRYALLLDIVQPTCRRSVCFTKGYGSYIEGTGSVLQTAEDV
QVENIYKSLTNLSQEEQITKLLILKLRYFTPKEIANLLGFPPEFGFPEKITVKQRYRLLGNSLNVHVVAKLIKILYE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for L3MBTL4-TRDMT1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for L3MBTL4-TRDMT1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for L3MBTL4-TRDMT1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource