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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Fusion gene:CBFA2T2-ACOX1 (FusionGDB2 ID:HG9139TG51)

Fusion Gene Summary for CBFA2T2-ACOX1

check button Fusion gene summary
Fusion gene informationFusion gene name: CBFA2T2-ACOX1
Fusion gene ID: hg9139tg51
HgeneTgene
Gene symbol

CBFA2T2

ACOX1

Gene ID

9139

51

Gene nameCBFA2/RUNX1 partner transcriptional co-repressor 2acyl-CoA oxidase 1
SynonymsEHT|MTGR1|ZMYND3|p85ACOX|PALMCOX|SCOX
Cytomap('CBFA2T2')('ACOX1')

20q11.21-q11.22

17q25.1

Type of geneprotein-codingprotein-coding
Descriptionprotein CBFA2T2CBFA2/RUNX1 translocation partner 2ETO homolog on chromosome 20ETO homologous on chromosome 20MTG8-like proteinMTG8-related protein 1core-binding factor, runt domain, alpha subunit 2; translocated to, 2myeloid translocation gene-relaperoxisomal acyl-coenzyme A oxidase 1AOXacyl-CoA oxidase 1, palmitoylacyl-CoA oxidase, straight-chainacyl-Coenzyme A oxidase 1, palmitoylpalmitoyl-CoA oxidaseperoxisomal fatty acyl-CoA oxidasestraight-chain acyl-CoA oxidase
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000342704, ENST00000375279, 
ENST00000344201, ENST00000346541, 
ENST00000359606, ENST00000397798, 
ENST00000397800, ENST00000491618, 
ENST00000492345, ENST00000543126, 
Fusion gene scores* DoF score26 X 9 X 12=280811 X 11 X 8=968
# samples 2714
** MAII scorelog2(27/2808*10)=-3.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/968*10)=-2.78958022032963
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CBFA2T2 [Title/Abstract] AND ACOX1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCBFA2T2(32078107)-ACOX1(73953647), # samples:3
Anticipated loss of major functional domain due to fusion event.CBFA2T2-ACOX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CBFA2T2-ACOX1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CBFA2T2-ACOX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CBFA2T2-ACOX1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCBFA2T2

GO:0010976

positive regulation of neuron projection development

19026687

HgeneCBFA2T2

GO:0045892

negative regulation of transcription, DNA-templated

23251453

TgeneACOX1

GO:0006629

lipid metabolic process

8117268


check buttonFusion gene breakpoints across CBFA2T2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ACOX1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8289-01ACBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
ChimerDB4STADTCGA-BR-8289CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-


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Fusion Gene ORF analysis for CBFA2T2-ACOX1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000342704ENST00000591857CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
5UTR-3CDSENST00000375279ENST00000293217CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
5UTR-3CDSENST00000375279ENST00000301608CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
5UTR-3CDSENST00000375279ENST00000537812CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
5UTR-5UTRENST00000375279ENST00000591857CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
In-frameENST00000342704ENST00000293217CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
In-frameENST00000342704ENST00000301608CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
In-frameENST00000342704ENST00000537812CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000344201ENST00000293217CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000344201ENST00000301608CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000344201ENST00000537812CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000346541ENST00000293217CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000346541ENST00000301608CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000346541ENST00000537812CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000359606ENST00000293217CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000359606ENST00000301608CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000359606ENST00000537812CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000397798ENST00000293217CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000397798ENST00000301608CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000397798ENST00000537812CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000397800ENST00000293217CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000397800ENST00000301608CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000397800ENST00000537812CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000491618ENST00000293217CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000491618ENST00000301608CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000491618ENST00000537812CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000492345ENST00000293217CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000492345ENST00000301608CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000492345ENST00000537812CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000543126ENST00000293217CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000543126ENST00000301608CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-3CDSENST00000543126ENST00000537812CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-5UTRENST00000344201ENST00000591857CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-5UTRENST00000346541ENST00000591857CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-5UTRENST00000359606ENST00000591857CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-5UTRENST00000397798ENST00000591857CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-5UTRENST00000397800ENST00000591857CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-5UTRENST00000491618ENST00000591857CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-5UTRENST00000492345ENST00000591857CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-
intron-5UTRENST00000543126ENST00000591857CBFA2T2chr20

32078107

+ACOX1chr17

73953647

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000342704CBFA2T2chr2032078107+ENST00000293217ACOX1chr1773953647-70092151811767528
ENST00000342704CBFA2T2chr2032078107+ENST00000537812ACOX1chr1773953647-70012151811767528
ENST00000342704CBFA2T2chr2032078107+ENST00000301608ACOX1chr1773953647-19392151811767528

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000342704ENST00000293217CBFA2T2chr2032078107+ACOX1chr1773953647-0.0006602940.99933964
ENST00000342704ENST00000537812CBFA2T2chr2032078107+ACOX1chr1773953647-0.0006607010.9993393
ENST00000342704ENST00000301608CBFA2T2chr2032078107+ACOX1chr1773953647-0.0046974360.99530256

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Fusion Genomic Features for CBFA2T2-ACOX1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for CBFA2T2-ACOX1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:32078107/chr17:73953647)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneACOX1chr20:32078107chr17:73953647ENST00000293217214658_660143661.0MotifNote=Microbody targeting signal
TgeneACOX1chr20:32078107chr17:73953647ENST00000301608214658_660143661.0MotifNote=Microbody targeting signal
TgeneACOX1chr20:32078107chr17:73953647ENST00000537812214658_660105623.0MotifNote=Microbody targeting signal

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000342704+111451_49111596.0Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000344201+16451_4910264.0Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000346541+112451_4910605.0Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000359606+111451_4910615.0Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000375279+112451_4910605.0Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397798+17451_4910264.0Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397800+111451_4910576.0Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000492345+113451_4910576.0Coiled coilOntology_term=ECO:0000255
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000342704+11133_9711596.0Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000344201+1633_970264.0Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000346541+11233_970605.0Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000359606+11133_970615.0Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000375279+11233_970605.0Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397798+1733_970264.0Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397800+11133_970576.0Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000492345+11333_970576.0Compositional biasNote=Pro-rich
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000342704+111113_20811596.0DomainTAFH
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000344201+16113_2080264.0DomainTAFH
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000346541+112113_2080605.0DomainTAFH
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000359606+111113_2080615.0DomainTAFH
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000375279+112113_2080605.0DomainTAFH
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397798+17113_2080264.0DomainTAFH
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397800+111113_2080576.0DomainTAFH
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000492345+113113_2080576.0DomainTAFH
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000342704+111331_37711596.0RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000342704+111435_48411596.0RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000344201+16331_3770264.0RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000344201+16435_4840264.0RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000346541+112331_3770605.0RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000346541+112435_4840605.0RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000359606+111331_3770615.0RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000359606+111435_4840615.0RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000375279+112331_3770605.0RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000375279+112435_4840605.0RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397798+17331_3770264.0RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397798+17435_4840264.0RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397800+111331_3770576.0RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397800+111435_4840576.0RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000492345+113331_3770576.0RegionNervy homology region 2 (NHR2)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000492345+113435_4840576.0RegionNervy homology region 3 (NHR3)
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000342704+111517_55311596.0Zinc fingerMYND-type
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000344201+16517_5530264.0Zinc fingerMYND-type
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000346541+112517_5530605.0Zinc fingerMYND-type
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000359606+111517_5530615.0Zinc fingerMYND-type
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000375279+112517_5530605.0Zinc fingerMYND-type
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397798+17517_5530264.0Zinc fingerMYND-type
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397800+111517_5530576.0Zinc fingerMYND-type
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000492345+113517_5530576.0Zinc fingerMYND-type


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Fusion Gene Sequence for CBFA2T2-ACOX1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>13330_13330_1_CBFA2T2-ACOX1_CBFA2T2_chr20_32078107_ENST00000342704_ACOX1_chr17_73953647_ENST00000293217_length(transcript)=7009nt_BP=215nt
AACGGCGGCGGCGGCGGCGGCGACGGCGACAGCAGCGGTGGTGGTGTCTGGTTAGCTCGGCGGCTGCAGATCTCGCGGCGACGCCTGCGA
GGGACCCGGGCCGCGGGTCGAGGCGGGCGGCGCCTGCGAGGGACCCGTGTCGCGGGTAGAGGCGGGCGGCGCGCGGCGGCGGCGCTCGGC
GATGGTAGGCGTCCCTGGAGCGGCCGCCTTCCAGCGAACTCACCTTCGAGGCTTGGAAACCACAGCCACGTATGACCCTGAAACCCAGGA
GTTCATTCTCAACAGTCCTACTGTGACCTCCATTAAATGGTGGCCTGGTGGGCTTGGAAAGACTTCAAATCATGCAATAGTTCTTGCCCA
GCTCATCACTAAGGGGAAATGCTATGGATTACATGCCTTTATCGTACCTATTCGTGAAATCGGGACCCATAAGCCTTTGCCAGGAATTAC
CGTTGGTGACATCGGCCCCAAATTTGGTTATGATGAGATAGACAATGGCTACCTCAAAATGGACAACCATCGTATTCCCAGAGAAAACAT
GCTGATGAAGTATGCCCAGGTGAAGCCTGATGGCACATACGTGAAACCGCTGAGTAACAAGCTGACTTACGGGACCATGGTGTTTGTCAG
GTCCTTCCTTGTGGGAGAAGCTGCTCGGGCTCTGTCTAAGGCGTGCACCATTGCCATCCGATACAGCGCTGTGAGGCACCAGTCTGAAAT
CAAGCCAGGTGAACCAGAACCACAGATTTTGGATTTTCAAACCCAGCAGTATAAACTCTTTCCACTCCTGGCCACTGCCTATGCCTTCCA
GTTTGTGGGCGCATACATGAAGGAGACCTATCACCGGATTAACGAAGGCATTGGTCAAGGGGACCTGAGTGAACTGCCTGAGCTTCATGC
CCTCACCGCTGGACTGAAGGCTTTCACCTCCTGGACTGCAAACACTGGCATTGAAGCATGTCGGATGGCTTGTGGTGGGCATGGCTATTC
TCATTGCAGTGGTCTTCCAAATATTTATGTCAATTTCACCCCAAGCTGTACCTTTGAGGGAGAAAACACTGTCATGATGCTCCAGACGGC
TAGGTTCCTGATGAAAAGTTATGATCAGGTGCACTCAGGAAAGTTGGTGTGTGGCATGGTGTCCTATTTGAACGACCTGCCCAGTCAGCG
CATCCAGCCACAGCAGGTAGCAGTCTGGCCAACCATGGTGGATATCAACAGCCCCGAAAGCCTAACCGAAGCATATAAACTCCGTGCAGC
CAGATTAGTAGAAATTGCTGCAAAAAACCTTCAAAAAGAAGTGATTCACAGAAAAAGCAAGGAGGTAGCTTGGAACCTAACTTCTGTTGA
CCTTGTTCGAGCAAGTGAGGCACATTGCCACTATGTGGTAGTTAAGCTCTTTTCAGAAAAACTCCTCAAAATTCAAGATAAAGCCATTCA
AGCTGTCTTAAGGAGTTTATGTCTGCTGTATTCTCTGTATGGAATCAGTCAGAACGCGGGGGATTTCCTTCAGGGGAGCATCATGACAGA
GCCTCAGATTACACAAGTAAACCAGCGTGTAAAGGAGTTACTCACTCTGATTCGCTCAGATGCTGTTGCTTTGGTTGATGCATTTGATTT
TCAGGATGTGACACTTGGCTCTGTGCTTGGCCGCTATGATGGGAATGTGTATGAAAACTTGTTTGAGTGGGCTAAGAACTCCCCACTGAA
CAAAGCAGAGGTCCACGAATCTTACAAGCACCTGAAGTCACTGCAGTCCAAGCTCTGAAGTGTCACAAGGACAAGTTTAATCTGCTTCAG
AAAGCGCCTGTGTGCAACTCAAATTTTGTGGAATCTTTTTCGAATTCAAATAGCTATAGAGCAAATGATAAATTGACCCCTTTTTATAAA
TGGAGGGAAAAAATGAACAGATTTCAGAGATTAAATGAAAAAAAGCAGATGTTTTAAGTGCAATTAACACTGAAAGAGACCTGTTAAACC
ATTCAGAAAAAGCTTAAGAAATGCGATATGACTTCCTTTTGTAATGCTGCTGATCCCAGTAGACTATGACTTTTGATAATTAGCAGAATT
TAACTACTGAGTAGTTGATTATTTTCACATTTTAATTGCTAATCACTGGCTATATAAGTGTTTTTAAGCAAAGGTATTTTTGAAGTGGTG
TAGAACCCTTCCAAGCTTTCCTGCTCAGTGTTCTACCAGACTTACCCTGGGGCCTGGCTTAAAAGCAGGATTGAAGAAAAGGGACTGGGG
GAAGGAAACTTATTGGAAAACTTGATGCGAATGAGTTTCTGCTTGGCACAGTCTCTGCCTGCTTGCTCTCCTTTGCTGATGGATTGCATT
TATCAAACTATTCATGCTAGCATTTTTCCAACGAGGGAACTTATTCCGCACGGGCCTACTGTAGGACCATTGTCTCGTGTAATTAGGAAT
TTTCCATTTGAAGGATTGCTAAATTGTCACAGTAGTAGGAAGTATAGGGAAACCTCTCAGCTGTGGCACTGTTGTAGCTTTGGAGTGCAG
AGTGTAACTCTGGGACAATCAGATTTCACATATTCTGTCATCTTGGCATAAGCCATTAAAAGCTTGGAGATTACTGTATTTGGCATTAAA
AAAAAATGTCACTTAGGTCAGCACTCCCAGACGTAGCACAGAAAAACCCTTTGACACAAACCATGTGTTCTGATTTTTGGTTCAGAAAAT
ATTGAAACTGTGAGTTGTTTTTTTTTTAACAACTGGGAAAAAACAAAAACAAAAAACTATAGTTAGAAAAATGGAAGTTCCATAGGTTCT
ATTTCTTACTCTATGTATGGCTTTGTTTTCAGTCTATTTCTAGGAGCTTTCTCTGAATCGCTAATTGTCCTTTCAGTTGAAATCTAATTT
ATACAATCATTCTATACTTAAAGGTTAAATACATCTTAATTAATTTTTTCTTAAAGTCAATGTAAGTCACTTTGTTTTGTTTTTTTTTAA
TCTACGCCATATGCCTCATGAAACCAGCTGTTCTAGAATCAGTCCTGAGAATATGGCTTAATTCCATGGAAACATAACTCCTATCTTGGG
ACCTGACATAATATCTATCTATCCTGGGGAACTGGTAATATGAGACTTATAGGTTACAGCAGAAATGCTACATGTTGACAAAAGCCTTAA
TCGTTCCACTGGGAGAACTAATTGATAATTGTGTTAAGATTGAAGATTAACCCTGTGTTAATCTCACTTGAGTCTATCCTGACAGTAGTT
CAGATTCTGGAAAATGATAAACTGACCTGCTAGATGTAGAATTGTTTCAAAATTAGTGTTGAAATACCTTGTTCACAGATGAATATCTGG
GCAGGATCTGAGGGTGTTTGGAATGACACCCCCCAATCCAGTTGCATAGATGGGATGTCTTTGCAGGTTTGAGGAGATCATCGACCTGCA
GAGCCCCCTTTGACCCAGTACCTCACGTTTTATTTAAAATCTAAATCTGGGGCCAGGCGTGGTGGCTCACGCCTGTAATCCAAGCACTTT
GGGAGGCCGAAGCGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCATCCTGGCCAACATGGTGAAACCCCGTCTCTACTGAAAAAAATA
CAAAAATTAGCTGGGCATGGTGGTAGCACGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGATAATCGCTTGAACTTGGCGGGT
AGAGGTTGCAGTGAGCCAAGATGGTGCCACTACACTGCAGCCTGGGTGGCTGAGCGAGACTCCGTCTCAAAAAAAAAATCTAAATCTGAC
ATTTGATGCTATTTTTATTAATATTGGAATGTTCTGTCTTGAACTTTATTCAATATAATCAAGAATAAAGATAGAGTAAACGTCACTGAT
TTGTACTATTAAGAGAGAAAAAATATGCCACACAACTAAACATAGGTTTAAATTATGAAGAAATTTAGAATAGAGGTTTATTAGATTTAG
GGAACACTAAGAACAAAAAAGGAAGGAGTGATACCTGCCTGAGTGGACAGCTGTAAATCAGCTGTAATTACTGCAGTTGTACCAATAGTT
GTGAGTGGCTCCAGTCACTTTAGGAGTCCTTGGAAGTACTTGGTACACATTTGTTGGCTGTACCTTAAAGGAAGTGGCAAGTCCAGTTTG
TTCTCTCTACCACACTAGACTGCCACTGACAAGTTTGGGTCTGTTGGATTCAAAATTTTGTAAGCCATTTTCACAAGTACAAAGATACAT
TTTAACCTTGTCTTCTCCAAAATTACTGAGTAGGAATTTTATTTTTATCTTTTTGAGACAGGGTATCACTGTCACCCAGACTGGAGTGCA
GTGGTGGGATCTTGGCTTACTGTGACCTCTGCCTCCCGGGTTCAAATGGTCCTCCCTCCTCAGTCTCCTGAGTAGCTGGGACGACAGGCA
CGTGCCACCATGCCCAGCTAATTTGTTCTATTTTTTCTGTAGAGACGGGGTTTTGCCATGTTGCCCAGGCTGGTCTCAGACTCCTGGGCT
CAAGCGATCATTTCGCCTCAGCCTCCCAAAGTGCTGAGATTATAGGTGTGAGCCACAGCATCTGGCCCAGAGTGAGGAGAATTAATGAGA
TTTTTTGTGTGTGTTAGATAATATTGATTTAAGCCTTTTTTTAAAAAGTACTCTCAACCAAATACAAAATTGAAAATGTGAGGTTTAATA
GAAATGTGTTGGCTATTTGCAATGGATTTTCTTCTTGCCCAAGTGTTTGGAGTTCTACTTTATGCTCTGTATTTAAAAATTAGTGACCTC
AAAGCAGAGTTGATGACACAGGCTTTGGGGCCCTCATGTTCTTGTCTTTAGAACATATCACTACTAAGTATCAGCTTATCTTCAGAACAT
TACAACATTCACCGTGTTCATATGCTTTCTGAGAAGTCACCACTTGTAATTTCAGATCACATACACCTGAAGGCATTTTATAGTTCCTAA
AGTTAACATGTTAGATCTTTTTTTTCCACCCCATGAGGGTCTCACTCTCACCCAGGCTGGAATGCAGTGGTGTGATTGTAGCACACTTTG
GCCACCAACTCCTGGGCTCAAGTGATCCTCCTGCTTTGGCCTCCTCTGAGAAGCTGGGATTACTGGTGCACACCACCACACCTGGCTAAT
TTTTTATTTTTTTTTATTTTTGGAAATAGGGTATGGCTATGTTGCCTTGGGCCCGTCATGAACTCCTAGCCTCAGGTGACCCTCCCACCT
CAGGCCTCCCAAAGGGTTGGGATTACAGGAGTGAGCTACTGCACTGGGCCAACATGTTAATTTTTTTTTTTTTTTTTTTGAGATGGAGTC
TCCCAGGCGGGAATGCAATGGTGCGATCTCGACTTCACTGCAATCTTCACCTCCCGGGTTCGAGCGATTCTCCCACCTCAGCCTCCTGAG
TAGCTGGGATTACAGGCACCTGCCATCACGCTCGGCTAATTTTTGTATTTTGAGCAGAGATGGAGTTTCACCATGTTGGCCAGGTGATCT
GCACTCCCACTCCCCCCACACTTCCCAAAGTGCTGGGATTACAGGCATAAGCCACAAGCCACCTCACCCAGCCAACATGTTACATCTTAA
TTCTTGGATTTTCTTCACTGCAGGGCTTTGGGTGGAGAAATAAAACTCTTCAAATGCATGATCTTGGAGATCCCTGTGAATCAATAATTC
TTTAGACAACTGCGGCTCAAAATCCCTCCTTTCCCTTTTCCGAGTTATTCCATCCATCTTATTAGAAAGGAAGTGAATTAGGTGTAGGTG
GTCTGTAACACCTGCACATCTTTTTATACGTGTAGAGGGTATGCCTGGGATATATAGGTTGTCTTCAAGCAGTAGCTGCTACTACAGCTA
GAGAGAGGAGGAGTGCCAGGAAACTGATGACCTGAGACCAAGAGTCTTGTTGATGTTCTGACTTAGATAAAGGTTTTGATCATTTTCATG
AAATAATGCAGGGAAGTCATTTCTGCTGTTTCTTTACTACTCCATTCTTGGAGGATTAGAACAAGTCACACTGTAATTGACTAAAACGAC
TTTTTATTTTAAAATATTGATGGTGGGGTTTTGCTTTTTTTTTTTTTTTTTTTTTTGAGACGTTGTCTTGCTCTTTCACCCAGGGTAGAG
TGCAGTGGCGAAATCTTGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTCTGCCTCAGCCTCCTGAGAAGCTGGGATTACAG
CGCCTGCCACCATGCCTGTCTAGTTTTTTTGTATTTTTAGTAGAGACAGGGGTTTCACCAAGTTGGCCAGGCTGGTCTTGAACTCCTGAC
CTCGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCGGGCCAGTGTTTTTAACTGTCCACACTT
ACTAAATTTTCCAGTACTTCTTCCTATGGTTCATGATAGTAAACACAGAAACATATAAGGAACATTATTAGAGTTACCAGATGTTAGCTG
TTGCATATGTGCACATTCCTAGATTCAAGGGTGTTTTTGCCTTAAATTTAAGTGGGTCATTGGTTGTCTTGGGAAGATCATGGAAAATTC
GGGATTTTTTAGAATTCTGAACCAAAATATGTTTTGAGTGTTTCTTAGTAAATGTGTGATCTTCCACCTTCCACATTCAGACTGCGGACT
ACACTTCATAAATGCCTTTTTATTTCCAGTTATGGATTCAACTAAATGACTGCCTTGGGAGCACATAATTACTTTGCTACCTTTTTCCCC
CTTTGCTGTTGTGGCTCGAGTTTGGTTCTCACCTGAGAAGATGCATTGAGCATATGTTGTTACCCAGCCCTGGCTTAATGGTGTCCTGTG
GGGTAGGGGTGGGAGGACGAGGGGCACGGGGCCAGAGCATGTGAATGGATCATGGTTGGACAGCTGTGACCTGCCAGCACTGCGGGTAAG

>13330_13330_1_CBFA2T2-ACOX1_CBFA2T2_chr20_32078107_ENST00000342704_ACOX1_chr17_73953647_ENST00000293217_length(amino acids)=528AA_BP=12
MVGVPGAAAFQRTHLRGLETTATYDPETQEFILNSPTVTSIKWWPGGLGKTSNHAIVLAQLITKGKCYGLHAFIVPIREIGTHKPLPGIT
VGDIGPKFGYDEIDNGYLKMDNHRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGEAARALSKACTIAIRYSAVRHQSEI
KPGEPEPQILDFQTQQYKLFPLLATAYAFQFVGAYMKETYHRINEGIGQGDLSELPELHALTAGLKAFTSWTANTGIEACRMACGGHGYS
HCSGLPNIYVNFTPSCTFEGENTVMMLQTARFLMKSYDQVHSGKLVCGMVSYLNDLPSQRIQPQQVAVWPTMVDINSPESLTEAYKLRAA
RLVEIAAKNLQKEVIHRKSKEVAWNLTSVDLVRASEAHCHYVVVKLFSEKLLKIQDKAIQAVLRSLCLLYSLYGISQNAGDFLQGSIMTE

--------------------------------------------------------------
>13330_13330_2_CBFA2T2-ACOX1_CBFA2T2_chr20_32078107_ENST00000342704_ACOX1_chr17_73953647_ENST00000301608_length(transcript)=1939nt_BP=215nt
AACGGCGGCGGCGGCGGCGGCGACGGCGACAGCAGCGGTGGTGGTGTCTGGTTAGCTCGGCGGCTGCAGATCTCGCGGCGACGCCTGCGA
GGGACCCGGGCCGCGGGTCGAGGCGGGCGGCGCCTGCGAGGGACCCGTGTCGCGGGTAGAGGCGGGCGGCGCGCGGCGGCGGCGCTCGGC
GATGGTAGGCGTCCCTGGAGCGGCCGCCTTCCAGCGAACTCACCTTCGAGGCTTGGAAACCACAGCCACGTATGACCCTGAAACCCAGGA
GTTCATTCTCAACAGTCCTACTGTGACCTCCATTAAATGGTGGCCTGGTGGGCTTGGAAAGACTTCAAATCATGCAATAGTTCTTGCCCA
GCTCATCACTAAGGGGAAATGCTATGGATTACATGCCTTTATCGTACCTATTCGTGAAATCGGGACCCATAAGCCTTTGCCAGGAATTAC
CGTTGGTGACATCGGCCCCAAATTTGGTTATGATGAGATAGACAATGGCTACCTCAAAATGGACAACCATCGTATTCCCAGAGAAAACAT
GCTGATGAAGTATGCCCAGGTGAAGCCTGATGGCACATACGTGAAACCGCTGAGTAACAAGCTGACTTACGGGACCATGGTGTTTGTCAG
GTCCTTCCTTGTGGGAGAAGCTGCTCGGGCTCTGTCTAAGGCGTGCACCATTGCCATCCGATACAGCGCTGTGAGGCACCAGTCTGAAAT
CAAGCCAGGTGAACCAGAACCACAGATTTTGGATTTTCAAACCCAGCAGTATAAACTCTTTCCACTCCTGGCCACTGCCTATGCCTTCCA
GTTTGTGGGCGCATACATGAAGGAGACCTATCACCGGATTAACGAAGGCATTGGTCAAGGGGACCTGAGTGAACTGCCTGAGCTTCATGC
CCTCACCGCTGGACTGAAGGCTTTCACCTCCTGGACTGCAAACACTGGCATTGAAGCATGTCGGATGGCTTGTGGTGGGCATGGCTATTC
TCATTGCAGTGGTCTTCCAAATATTTATGTCAATTTCACCCCAAGCTGTACCTTTGAGGGAGAAAACACTGTCATGATGCTCCAGACGGC
TAGGTTCCTGATGAAAAGTTATGATCAGGTGCACTCAGGAAAGTTGGTGTGTGGCATGGTGTCCTATTTGAACGACCTGCCCAGTCAGCG
CATCCAGCCACAGCAGGTAGCAGTCTGGCCAACCATGGTGGATATCAACAGCCCCGAAAGCCTAACCGAAGCATATAAACTCCGTGCAGC
CAGATTAGTAGAAATTGCTGCAAAAAACCTTCAAAAAGAAGTGATTCACAGAAAAAGCAAGGAGGTAGCTTGGAACCTAACTTCTGTTGA
CCTTGTTCGAGCAAGTGAGGCACATTGCCACTATGTGGTAGTTAAGCTCTTTTCAGAAAAACTCCTCAAAATTCAAGATAAAGCCATTCA
AGCTGTCTTAAGGAGTTTATGTCTGCTGTATTCTCTGTATGGAATCAGTCAGAACGCGGGGGATTTCCTTCAGGGGAGCATCATGACAGA
GCCTCAGATTACACAAGTAAACCAGCGTGTAAAGGAGTTACTCACTCTGATTCGCTCAGATGCTGTTGCTTTGGTTGATGCATTTGATTT
TCAGGATGTGACACTTGGCTCTGTGCTTGGCCGCTATGATGGGAATGTGTATGAAAACTTGTTTGAGTGGGCTAAGAACTCCCCACTGAA
CAAAGCAGAGGTCCACGAATCTTACAAGCACCTGAAGTCACTGCAGTCCAAGCTCTGAAGTGTCACAAGGACAAGTTTAATCTGCTTCAG
AAAGCGCCTGTGTGCAACTCAAATTTTGTGGAATCTTTTTCGAATTCAAATAGCTATAGAGCAAATGATAAATTGACCCCTTTTTATAAA

>13330_13330_2_CBFA2T2-ACOX1_CBFA2T2_chr20_32078107_ENST00000342704_ACOX1_chr17_73953647_ENST00000301608_length(amino acids)=528AA_BP=12
MVGVPGAAAFQRTHLRGLETTATYDPETQEFILNSPTVTSIKWWPGGLGKTSNHAIVLAQLITKGKCYGLHAFIVPIREIGTHKPLPGIT
VGDIGPKFGYDEIDNGYLKMDNHRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGEAARALSKACTIAIRYSAVRHQSEI
KPGEPEPQILDFQTQQYKLFPLLATAYAFQFVGAYMKETYHRINEGIGQGDLSELPELHALTAGLKAFTSWTANTGIEACRMACGGHGYS
HCSGLPNIYVNFTPSCTFEGENTVMMLQTARFLMKSYDQVHSGKLVCGMVSYLNDLPSQRIQPQQVAVWPTMVDINSPESLTEAYKLRAA
RLVEIAAKNLQKEVIHRKSKEVAWNLTSVDLVRASEAHCHYVVVKLFSEKLLKIQDKAIQAVLRSLCLLYSLYGISQNAGDFLQGSIMTE

--------------------------------------------------------------
>13330_13330_3_CBFA2T2-ACOX1_CBFA2T2_chr20_32078107_ENST00000342704_ACOX1_chr17_73953647_ENST00000537812_length(transcript)=7001nt_BP=215nt
AACGGCGGCGGCGGCGGCGGCGACGGCGACAGCAGCGGTGGTGGTGTCTGGTTAGCTCGGCGGCTGCAGATCTCGCGGCGACGCCTGCGA
GGGACCCGGGCCGCGGGTCGAGGCGGGCGGCGCCTGCGAGGGACCCGTGTCGCGGGTAGAGGCGGGCGGCGCGCGGCGGCGGCGCTCGGC
GATGGTAGGCGTCCCTGGAGCGGCCGCCTTCCAGCGAACTCACCTTCGAGGCTTGGAAACCACAGCCACGTATGACCCTGAAACCCAGGA
GTTCATTCTCAACAGTCCTACTGTGACCTCCATTAAATGGTGGCCTGGTGGGCTTGGAAAGACTTCAAATCATGCAATAGTTCTTGCCCA
GCTCATCACTAAGGGGAAATGCTATGGATTACATGCCTTTATCGTACCTATTCGTGAAATCGGGACCCATAAGCCTTTGCCAGGAATTAC
CGTTGGTGACATCGGCCCCAAATTTGGTTATGATGAGATAGACAATGGCTACCTCAAAATGGACAACCATCGTATTCCCAGAGAAAACAT
GCTGATGAAGTATGCCCAGGTGAAGCCTGATGGCACATACGTGAAACCGCTGAGTAACAAGCTGACTTACGGGACCATGGTGTTTGTCAG
GTCCTTCCTTGTGGGAGAAGCTGCTCGGGCTCTGTCTAAGGCGTGCACCATTGCCATCCGATACAGCGCTGTGAGGCACCAGTCTGAAAT
CAAGCCAGGTGAACCAGAACCACAGATTTTGGATTTTCAAACCCAGCAGTATAAACTCTTTCCACTCCTGGCCACTGCCTATGCCTTCCA
GTTTGTGGGCGCATACATGAAGGAGACCTATCACCGGATTAACGAAGGCATTGGTCAAGGGGACCTGAGTGAACTGCCTGAGCTTCATGC
CCTCACCGCTGGACTGAAGGCTTTCACCTCCTGGACTGCAAACACTGGCATTGAAGCATGTCGGATGGCTTGTGGTGGGCATGGCTATTC
TCATTGCAGTGGTCTTCCAAATATTTATGTCAATTTCACCCCAAGCTGTACCTTTGAGGGAGAAAACACTGTCATGATGCTCCAGACGGC
TAGGTTCCTGATGAAAAGTTATGATCAGGTGCACTCAGGAAAGTTGGTGTGTGGCATGGTGTCCTATTTGAACGACCTGCCCAGTCAGCG
CATCCAGCCACAGCAGGTAGCAGTCTGGCCAACCATGGTGGATATCAACAGCCCCGAAAGCCTAACCGAAGCATATAAACTCCGTGCAGC
CAGATTAGTAGAAATTGCTGCAAAAAACCTTCAAAAAGAAGTGATTCACAGAAAAAGCAAGGAGGTAGCTTGGAACCTAACTTCTGTTGA
CCTTGTTCGAGCAAGTGAGGCACATTGCCACTATGTGGTAGTTAAGCTCTTTTCAGAAAAACTCCTCAAAATTCAAGATAAAGCCATTCA
AGCTGTCTTAAGGAGTTTATGTCTGCTGTATTCTCTGTATGGAATCAGTCAGAACGCGGGGGATTTCCTTCAGGGGAGCATCATGACAGA
GCCTCAGATTACACAAGTAAACCAGCGTGTAAAGGAGTTACTCACTCTGATTCGCTCAGATGCTGTTGCTTTGGTTGATGCATTTGATTT
TCAGGATGTGACACTTGGCTCTGTGCTTGGCCGCTATGATGGGAATGTGTATGAAAACTTGTTTGAGTGGGCTAAGAACTCCCCACTGAA
CAAAGCAGAGGTCCACGAATCTTACAAGCACCTGAAGTCACTGCAGTCCAAGCTCTGAAGTGTCACAAGGACAAGTTTAATCTGCTTCAG
AAAGCGCCTGTGTGCAACTCAAATTTTGTGGAATCTTTTTCGAATTCAAATAGCTATAGAGCAAATGATAAATTGACCCCTTTTTATAAA
TGGAGGGAAAAAATGAACAGATTTCAGAGATTAAATGAAAAAAAGCAGATGTTTTAAGTGCAATTAACACTGAAAGAGACCTGTTAAACC
ATTCAGAAAAAGCTTAAGAAATGCGATATGACTTCCTTTTGTAATGCTGCTGATCCCAGTAGACTATGACTTTTGATAATTAGCAGAATT
TAACTACTGAGTAGTTGATTATTTTCACATTTTAATTGCTAATCACTGGCTATATAAGTGTTTTTAAGCAAAGGTATTTTTGAAGTGGTG
TAGAACCCTTCCAAGCTTTCCTGCTCAGTGTTCTACCAGACTTACCCTGGGGCCTGGCTTAAAAGCAGGATTGAAGAAAAGGGACTGGGG
GAAGGAAACTTATTGGAAAACTTGATGCGAATGAGTTTCTGCTTGGCACAGTCTCTGCCTGCTTGCTCTCCTTTGCTGATGGATTGCATT
TATCAAACTATTCATGCTAGCATTTTTCCAACGAGGGAACTTATTCCGCACGGGCCTACTGTAGGACCATTGTCTCGTGTAATTAGGAAT
TTTCCATTTGAAGGATTGCTAAATTGTCACAGTAGTAGGAAGTATAGGGAAACCTCTCAGCTGTGGCACTGTTGTAGCTTTGGAGTGCAG
AGTGTAACTCTGGGACAATCAGATTTCACATATTCTGTCATCTTGGCATAAGCCATTAAAAGCTTGGAGATTACTGTATTTGGCATTAAA
AAAAAATGTCACTTAGGTCAGCACTCCCAGACGTAGCACAGAAAAACCCTTTGACACAAACCATGTGTTCTGATTTTTGGTTCAGAAAAT
ATTGAAACTGTGAGTTGTTTTTTTTTTAACAACTGGGAAAAAACAAAAACAAAAAACTATAGTTAGAAAAATGGAAGTTCCATAGGTTCT
ATTTCTTACTCTATGTATGGCTTTGTTTTCAGTCTATTTCTAGGAGCTTTCTCTGAATCGCTAATTGTCCTTTCAGTTGAAATCTAATTT
ATACAATCATTCTATACTTAAAGGTTAAATACATCTTAATTAATTTTTTCTTAAAGTCAATGTAAGTCACTTTGTTTTGTTTTTTTTTAA
TCTACGCCATATGCCTCATGAAACCAGCTGTTCTAGAATCAGTCCTGAGAATATGGCTTAATTCCATGGAAACATAACTCCTATCTTGGG
ACCTGACATAATATCTATCTATCCTGGGGAACTGGTAATATGAGACTTATAGGTTACAGCAGAAATGCTACATGTTGACAAAAGCCTTAA
TCGTTCCACTGGGAGAACTAATTGATAATTGTGTTAAGATTGAAGATTAACCCTGTGTTAATCTCACTTGAGTCTATCCTGACAGTAGTT
CAGATTCTGGAAAATGATAAACTGACCTGCTAGATGTAGAATTGTTTCAAAATTAGTGTTGAAATACCTTGTTCACAGATGAATATCTGG
GCAGGATCTGAGGGTGTTTGGAATGACACCCCCCAATCCAGTTGCATAGATGGGATGTCTTTGCAGGTTTGAGGAGATCATCGACCTGCA
GAGCCCCCTTTGACCCAGTACCTCACGTTTTATTTAAAATCTAAATCTGGGGCCAGGCGTGGTGGCTCACGCCTGTAATCCAAGCACTTT
GGGAGGCCGAAGCGGGTGGATCACCTGAGGTCAGGAGTTTGAGACCATCCTGGCCAACATGGTGAAACCCCGTCTCTACTGAAAAAAATA
CAAAAATTAGCTGGGCATGGTGGTAGCACGCGCCTGTAGTCCCAGCTACTCGGGAGGCTGAGGCAGGATAATCGCTTGAACTTGGCGGGT
AGAGGTTGCAGTGAGCCAAGATGGTGCCACTACACTGCAGCCTGGGTGGCTGAGCGAGACTCCGTCTCAAAAAAAAAATCTAAATCTGAC
ATTTGATGCTATTTTTATTAATATTGGAATGTTCTGTCTTGAACTTTATTCAATATAATCAAGAATAAAGATAGAGTAAACGTCACTGAT
TTGTACTATTAAGAGAGAAAAAATATGCCACACAACTAAACATAGGTTTAAATTATGAAGAAATTTAGAATAGAGGTTTATTAGATTTAG
GGAACACTAAGAACAAAAAAGGAAGGAGTGATACCTGCCTGAGTGGACAGCTGTAAATCAGCTGTAATTACTGCAGTTGTACCAATAGTT
GTGAGTGGCTCCAGTCACTTTAGGAGTCCTTGGAAGTACTTGGTACACATTTGTTGGCTGTACCTTAAAGGAAGTGGCAAGTCCAGTTTG
TTCTCTCTACCACACTAGACTGCCACTGACAAGTTTGGGTCTGTTGGATTCAAAATTTTGTAAGCCATTTTCACAAGTACAAAGATACAT
TTTAACCTTGTCTTCTCCAAAATTACTGAGTAGGAATTTTATTTTTATCTTTTTGAGACAGGGTATCACTGTCACCCAGACTGGAGTGCA
GTGGTGGGATCTTGGCTTACTGTGACCTCTGCCTCCCGGGTTCAAATGGTCCTCCCTCCTCAGTCTCCTGAGTAGCTGGGACGACAGGCA
CGTGCCACCATGCCCAGCTAATTTGTTCTATTTTTTCTGTAGAGACGGGGTTTTGCCATGTTGCCCAGGCTGGTCTCAGACTCCTGGGCT
CAAGCGATCATTTCGCCTCAGCCTCCCAAAGTGCTGAGATTATAGGTGTGAGCCACAGCATCTGGCCCAGAGTGAGGAGAATTAATGAGA
TTTTTTGTGTGTGTTAGATAATATTGATTTAAGCCTTTTTTTAAAAAGTACTCTCAACCAAATACAAAATTGAAAATGTGAGGTTTAATA
GAAATGTGTTGGCTATTTGCAATGGATTTTCTTCTTGCCCAAGTGTTTGGAGTTCTACTTTATGCTCTGTATTTAAAAATTAGTGACCTC
AAAGCAGAGTTGATGACACAGGCTTTGGGGCCCTCATGTTCTTGTCTTTAGAACATATCACTACTAAGTATCAGCTTATCTTCAGAACAT
TACAACATTCACCGTGTTCATATGCTTTCTGAGAAGTCACCACTTGTAATTTCAGATCACATACACCTGAAGGCATTTTATAGTTCCTAA
AGTTAACATGTTAGATCTTTTTTTTCCACCCCATGAGGGTCTCACTCTCACCCAGGCTGGAATGCAGTGGTGTGATTGTAGCACACTTTG
GCCACCAACTCCTGGGCTCAAGTGATCCTCCTGCTTTGGCCTCCTCTGAGAAGCTGGGATTACTGGTGCACACCACCACACCTGGCTAAT
TTTTTATTTTTTTTTATTTTTGGAAATAGGGTATGGCTATGTTGCCTTGGGCCCGTCATGAACTCCTAGCCTCAGGTGACCCTCCCACCT
CAGGCCTCCCAAAGGGTTGGGATTACAGGAGTGAGCTACTGCACTGGGCCAACATGTTAATTTTTTTTTTTTTTTTTTTGAGATGGAGTC
TCCCAGGCGGGAATGCAATGGTGCGATCTCGACTTCACTGCAATCTTCACCTCCCGGGTTCGAGCGATTCTCCCACCTCAGCCTCCTGAG
TAGCTGGGATTACAGGCACCTGCCATCACGCTCGGCTAATTTTTGTATTTTGAGCAGAGATGGAGTTTCACCATGTTGGCCAGGTGATCT
GCACTCCCACTCCCCCCACACTTCCCAAAGTGCTGGGATTACAGGCATAAGCCACAAGCCACCTCACCCAGCCAACATGTTACATCTTAA
TTCTTGGATTTTCTTCACTGCAGGGCTTTGGGTGGAGAAATAAAACTCTTCAAATGCATGATCTTGGAGATCCCTGTGAATCAATAATTC
TTTAGACAACTGCGGCTCAAAATCCCTCCTTTCCCTTTTCCGAGTTATTCCATCCATCTTATTAGAAAGGAAGTGAATTAGGTGTAGGTG
GTCTGTAACACCTGCACATCTTTTTATACGTGTAGAGGGTATGCCTGGGATATATAGGTTGTCTTCAAGCAGTAGCTGCTACTACAGCTA
GAGAGAGGAGGAGTGCCAGGAAACTGATGACCTGAGACCAAGAGTCTTGTTGATGTTCTGACTTAGATAAAGGTTTTGATCATTTTCATG
AAATAATGCAGGGAAGTCATTTCTGCTGTTTCTTTACTACTCCATTCTTGGAGGATTAGAACAAGTCACACTGTAATTGACTAAAACGAC
TTTTTATTTTAAAATATTGATGGTGGGGTTTTGCTTTTTTTTTTTTTTTTTTTTTTGAGACGTTGTCTTGCTCTTTCACCCAGGGTAGAG
TGCAGTGGCGAAATCTTGGCTCACTGCAACCTCTGCCTCCCGGGTTCAAGCAATTCTCTGCCTCAGCCTCCTGAGAAGCTGGGATTACAG
CGCCTGCCACCATGCCTGTCTAGTTTTTTTGTATTTTTAGTAGAGACAGGGGTTTCACCAAGTTGGCCAGGCTGGTCTTGAACTCCTGAC
CTCGTGATCCACCCACCTCGGCCTCCCAAAGTGCTGGGATTACAGGCGTGAGCCACCGTGCCGGGCCAGTGTTTTTAACTGTCCACACTT
ACTAAATTTTCCAGTACTTCTTCCTATGGTTCATGATAGTAAACACAGAAACATATAAGGAACATTATTAGAGTTACCAGATGTTAGCTG
TTGCATATGTGCACATTCCTAGATTCAAGGGTGTTTTTGCCTTAAATTTAAGTGGGTCATTGGTTGTCTTGGGAAGATCATGGAAAATTC
GGGATTTTTTAGAATTCTGAACCAAAATATGTTTTGAGTGTTTCTTAGTAAATGTGTGATCTTCCACCTTCCACATTCAGACTGCGGACT
ACACTTCATAAATGCCTTTTTATTTCCAGTTATGGATTCAACTAAATGACTGCCTTGGGAGCACATAATTACTTTGCTACCTTTTTCCCC
CTTTGCTGTTGTGGCTCGAGTTTGGTTCTCACCTGAGAAGATGCATTGAGCATATGTTGTTACCCAGCCCTGGCTTAATGGTGTCCTGTG
GGGTAGGGGTGGGAGGACGAGGGGCACGGGGCCAGAGCATGTGAATGGATCATGGTTGGACAGCTGTGACCTGCCAGCACTGCGGGTAAG

>13330_13330_3_CBFA2T2-ACOX1_CBFA2T2_chr20_32078107_ENST00000342704_ACOX1_chr17_73953647_ENST00000537812_length(amino acids)=528AA_BP=12
MVGVPGAAAFQRTHLRGLETTATYDPETQEFILNSPTVTSIKWWPGGLGKTSNHAIVLAQLITKGKCYGLHAFIVPIREIGTHKPLPGIT
VGDIGPKFGYDEIDNGYLKMDNHRIPRENMLMKYAQVKPDGTYVKPLSNKLTYGTMVFVRSFLVGEAARALSKACTIAIRYSAVRHQSEI
KPGEPEPQILDFQTQQYKLFPLLATAYAFQFVGAYMKETYHRINEGIGQGDLSELPELHALTAGLKAFTSWTANTGIEACRMACGGHGYS
HCSGLPNIYVNFTPSCTFEGENTVMMLQTARFLMKSYDQVHSGKLVCGMVSYLNDLPSQRIQPQQVAVWPTMVDINSPESLTEAYKLRAA
RLVEIAAKNLQKEVIHRKSKEVAWNLTSVDLVRASEAHCHYVVVKLFSEKLLKIQDKAIQAVLRSLCLLYSLYGISQNAGDFLQGSIMTE

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CBFA2T2-ACOX1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000342704+111107_21511.333333333333334596.0PRDM14
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000344201+16107_2150264.0PRDM14
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000346541+112107_2150605.0PRDM14
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000359606+111107_2150615.0PRDM14
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000375279+112107_2150605.0PRDM14
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397798+17107_2150264.0PRDM14
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000397800+111107_2150576.0PRDM14
HgeneCBFA2T2chr20:32078107chr17:73953647ENST00000492345+113107_2150576.0PRDM14


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CBFA2T2-ACOX1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CBFA2T2-ACOX1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC1849678Peroxisomal ACYL-COA oxidase deficiency7CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC2239176Liver carcinoma2CTD_human
TgeneC0002152Alloxan Diabetes1CTD_human
TgeneC0011853Diabetes Mellitus, Experimental1CTD_human
TgeneC0038433Streptozotocin Diabetes1CTD_human