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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:DCLK1-RCBTB1 (FusionGDB2 ID:HG9201TG55213)

Fusion Gene Summary for DCLK1-RCBTB1

check button Fusion gene summary
Fusion gene informationFusion gene name: DCLK1-RCBTB1
Fusion gene ID: hg9201tg55213
HgeneTgene
Gene symbol

DCLK1

RCBTB1

Gene ID

9201

55213

Gene namedoublecortin like kinase 1RCC1 and BTB domain containing protein 1
SynonymsCL1|CLICK1|DCAMKL1|DCDC3A|DCLKCLLD7|CLLL7|GLP|RDEOA
Cytomap('DCLK1')('RCBTB1')

13q13.3

13q14.2

Type of geneprotein-codingprotein-coding
Descriptionserine/threonine-protein kinase DCLK1doublecortin domain-containing protein 3Adoublecortin-like and CAM kinase-like 1RCC1 and BTB domain-containing protein 1CLL deletion region gene 7 proteinGDP/GTP exchange factor (GEF)-like proteinchronic lymphocytic leukemia deletion region gene 7 proteinregulator of chromosome condensation (RCC1) and BTB (POZ) domain containing
Modification date2020032020200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000255448, ENST00000360631, 
ENST00000379892, ENST00000379893, 
ENST00000460982, 
Fusion gene scores* DoF score12 X 11 X 3=3966 X 6 X 2=72
# samples 126
** MAII scorelog2(12/396*10)=-1.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: DCLK1 [Title/Abstract] AND RCBTB1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointDCLK1(36445361)-RCBTB1(50108398), # samples:2
Anticipated loss of major functional domain due to fusion event.DCLK1-RCBTB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DCLK1-RCBTB1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
DCLK1-RCBTB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DCLK1-RCBTB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
DCLK1-RCBTB1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
DCLK1-RCBTB1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
DCLK1-RCBTB1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across DCLK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RCBTB1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A0CW-01ADCLK1chr13

36445361

-RCBTB1chr13

50108398

-


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Fusion Gene ORF analysis for DCLK1-RCBTB1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000255448ENST00000471984DCLK1chr13

36445361

-RCBTB1chr13

50108398

-
5CDS-5UTRENST00000360631ENST00000471984DCLK1chr13

36445361

-RCBTB1chr13

50108398

-
5CDS-5UTRENST00000379892ENST00000471984DCLK1chr13

36445361

-RCBTB1chr13

50108398

-
5CDS-intronENST00000255448ENST00000546015DCLK1chr13

36445361

-RCBTB1chr13

50108398

-
5CDS-intronENST00000360631ENST00000546015DCLK1chr13

36445361

-RCBTB1chr13

50108398

-
5CDS-intronENST00000379892ENST00000546015DCLK1chr13

36445361

-RCBTB1chr13

50108398

-
Frame-shiftENST00000255448ENST00000258646DCLK1chr13

36445361

-RCBTB1chr13

50108398

-
Frame-shiftENST00000360631ENST00000258646DCLK1chr13

36445361

-RCBTB1chr13

50108398

-
Frame-shiftENST00000379892ENST00000258646DCLK1chr13

36445361

-RCBTB1chr13

50108398

-
In-frameENST00000255448ENST00000378302DCLK1chr13

36445361

-RCBTB1chr13

50108398

-
In-frameENST00000360631ENST00000378302DCLK1chr13

36445361

-RCBTB1chr13

50108398

-
In-frameENST00000379892ENST00000378302DCLK1chr13

36445361

-RCBTB1chr13

50108398

-
intron-3CDSENST00000379893ENST00000258646DCLK1chr13

36445361

-RCBTB1chr13

50108398

-
intron-3CDSENST00000379893ENST00000378302DCLK1chr13

36445361

-RCBTB1chr13

50108398

-
intron-3CDSENST00000460982ENST00000258646DCLK1chr13

36445361

-RCBTB1chr13

50108398

-
intron-3CDSENST00000460982ENST00000378302DCLK1chr13

36445361

-RCBTB1chr13

50108398

-
intron-5UTRENST00000379893ENST00000471984DCLK1chr13

36445361

-RCBTB1chr13

50108398

-
intron-5UTRENST00000460982ENST00000471984DCLK1chr13

36445361

-RCBTB1chr13

50108398

-
intron-intronENST00000379893ENST00000546015DCLK1chr13

36445361

-RCBTB1chr13

50108398

-
intron-intronENST00000460982ENST00000546015DCLK1chr13

36445361

-RCBTB1chr13

50108398

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000360631DCLK1chr1336445361-ENST00000378302RCBTB1chr1350108398-346111522001174324
ENST00000255448DCLK1chr1336445361-ENST00000378302RCBTB1chr1350108398-346111522001174324
ENST00000379892DCLK1chr1336445361-ENST00000378302RCBTB1chr1350108398-346111522001174324

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360631ENST00000378302DCLK1chr1336445361-RCBTB1chr1350108398-0.0010893020.99891067
ENST00000255448ENST00000378302DCLK1chr1336445361-RCBTB1chr1350108398-0.0010893020.99891067
ENST00000379892ENST00000378302DCLK1chr1336445361-RCBTB1chr1350108398-0.0010893020.99891067

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Fusion Genomic Features for DCLK1-RCBTB1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for DCLK1-RCBTB1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr13:36445361/chr13:50108398)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDCLK1chr13:36445361chr13:50108398ENST00000255448-518186_269313730.0DomainDoublecortin 2
HgeneDCLK1chr13:36445361chr13:50108398ENST00000255448-51857_143313730.0DomainDoublecortin 1
HgeneDCLK1chr13:36445361chr13:50108398ENST00000360631-517186_269313741.0DomainDoublecortin 2
HgeneDCLK1chr13:36445361chr13:50108398ENST00000360631-51757_143313741.0DomainDoublecortin 1
TgeneRCBTB1chr13:36445361chr13:50108398ENST00000546015010370_4370356.0DomainBTB 1
TgeneRCBTB1chr13:36445361chr13:50108398ENST00000546015010470_4990356.0DomainBTB 2
TgeneRCBTB1chr13:36445361chr13:50108398ENST00000546015010147_1980356.0RepeatNote=RCC1 3
TgeneRCBTB1chr13:36445361chr13:50108398ENST00000546015010199_2500356.0RepeatNote=RCC1 4
TgeneRCBTB1chr13:36445361chr13:50108398ENST00000546015010252_3020356.0RepeatNote=RCC1 5
TgeneRCBTB1chr13:36445361chr13:50108398ENST00000546015010304_3560356.0RepeatNote=RCC1 6
TgeneRCBTB1chr13:36445361chr13:50108398ENST0000054601501040_910356.0RepeatNote=RCC1 1
TgeneRCBTB1chr13:36445361chr13:50108398ENST0000054601501093_1450356.0RepeatNote=RCC1 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneDCLK1chr13:36445361chr13:50108398ENST00000255448-518288_340313730.0Compositional biasNote=Pro/Ser-rich
HgeneDCLK1chr13:36445361chr13:50108398ENST00000255448-518698_701313730.0Compositional biasNote=Poly-Arg
HgeneDCLK1chr13:36445361chr13:50108398ENST00000360631-517288_340313741.0Compositional biasNote=Pro/Ser-rich
HgeneDCLK1chr13:36445361chr13:50108398ENST00000360631-517698_701313741.0Compositional biasNote=Poly-Arg
HgeneDCLK1chr13:36445361chr13:50108398ENST00000379893-113288_3400434.0Compositional biasNote=Pro/Ser-rich
HgeneDCLK1chr13:36445361chr13:50108398ENST00000379893-113698_7010434.0Compositional biasNote=Poly-Arg
HgeneDCLK1chr13:36445361chr13:50108398ENST00000255448-518390_647313730.0DomainProtein kinase
HgeneDCLK1chr13:36445361chr13:50108398ENST00000360631-517390_647313741.0DomainProtein kinase
HgeneDCLK1chr13:36445361chr13:50108398ENST00000379893-113186_2690434.0DomainDoublecortin 2
HgeneDCLK1chr13:36445361chr13:50108398ENST00000379893-113390_6470434.0DomainProtein kinase
HgeneDCLK1chr13:36445361chr13:50108398ENST00000379893-11357_1430434.0DomainDoublecortin 1
HgeneDCLK1chr13:36445361chr13:50108398ENST00000255448-518396_404313730.0Nucleotide bindingATP
HgeneDCLK1chr13:36445361chr13:50108398ENST00000360631-517396_404313741.0Nucleotide bindingATP
HgeneDCLK1chr13:36445361chr13:50108398ENST00000379893-113396_4040434.0Nucleotide bindingATP
TgeneRCBTB1chr13:36445361chr13:50108398ENST00000258646911370_437485532.0DomainBTB 1
TgeneRCBTB1chr13:36445361chr13:50108398ENST00000258646911470_499485532.0DomainBTB 2
TgeneRCBTB1chr13:36445361chr13:50108398ENST000003783021113370_437485532.0DomainBTB 1
TgeneRCBTB1chr13:36445361chr13:50108398ENST000003783021113470_499485532.0DomainBTB 2
TgeneRCBTB1chr13:36445361chr13:50108398ENST00000258646911147_198485532.0RepeatNote=RCC1 3
TgeneRCBTB1chr13:36445361chr13:50108398ENST00000258646911199_250485532.0RepeatNote=RCC1 4
TgeneRCBTB1chr13:36445361chr13:50108398ENST00000258646911252_302485532.0RepeatNote=RCC1 5
TgeneRCBTB1chr13:36445361chr13:50108398ENST00000258646911304_356485532.0RepeatNote=RCC1 6
TgeneRCBTB1chr13:36445361chr13:50108398ENST0000025864691140_91485532.0RepeatNote=RCC1 1
TgeneRCBTB1chr13:36445361chr13:50108398ENST0000025864691193_145485532.0RepeatNote=RCC1 2
TgeneRCBTB1chr13:36445361chr13:50108398ENST000003783021113147_198485532.0RepeatNote=RCC1 3
TgeneRCBTB1chr13:36445361chr13:50108398ENST000003783021113199_250485532.0RepeatNote=RCC1 4
TgeneRCBTB1chr13:36445361chr13:50108398ENST000003783021113252_302485532.0RepeatNote=RCC1 5
TgeneRCBTB1chr13:36445361chr13:50108398ENST000003783021113304_356485532.0RepeatNote=RCC1 6
TgeneRCBTB1chr13:36445361chr13:50108398ENST00000378302111340_91485532.0RepeatNote=RCC1 1
TgeneRCBTB1chr13:36445361chr13:50108398ENST00000378302111393_145485532.0RepeatNote=RCC1 2


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Fusion Gene Sequence for DCLK1-RCBTB1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>21622_21622_1_DCLK1-RCBTB1_DCLK1_chr13_36445361_ENST00000255448_RCBTB1_chr13_50108398_ENST00000378302_length(transcript)=3461nt_BP=1152nt
GCACATCCCTGCACTAGTGGCCGCAACCGAGGCGCCGCGCTCCAGCAGCTGCTGCCGCCCAGCCCGGCCCCGCCGCCGCCCCCCAGCCCT
GCAGCCCCGCAGCCCCGGCCGCGCCCAGCCCGGCGAGGACAGCACCAGGAGGCGGCCCCCAGCGCGGCCACAAAGACCCCCGGCGGCGTC
TCTCCGCGGACCGGTCCTACTTGAAGTCCATCATGTCCTTCGGCAGAGACATGGAGCTGGAGCACTTCGACGAGCGGGATAAGGCGCAGA
GATACAGCCGAGGGTCGCGGGTGAACGGCCTGCCGAGCCCGACGCACAGCGCCCACTGCAGCTTCTACCGCACCCGCACGCTGCAGACGC
TCAGCTCCGAGAAGAAGGCCAAGAAAGTTCGTTTCTATCGAAACGGAGATCGATACTTCAAAGGGATTGTGTATGCCATCTCCCCAGACC
GGTTCCGATCTTTTGAGGCCCTGCTGGCTGATTTGACCCGAACTCTGTCGGATAACGTGAATTTGCCCCAGGGAGTGAGAACAATCTACA
CCATTGATGGGCTCAAGAAGATTTCCAGCCTGGACCAACTGGTGGAAGGAGAGAGTTATGTATGTGGCTCCATAGAGCCCTTCAAGAAAC
TGGAGTACACCAAGAATGTGAACCCCAACTGGTCGGTGAACGTCAAGACCACCTCGGCTTCTCGGGCAGTGTCTTCACTGGCCACTGCCA
AAGGAAGCCCTTCAGAGGTGCGAGAGAATAAGGATTTCATTCGGCCCAAGCTGGTCACCATCATCAGAAGTGGCGTGAAGCCACGGAAAG
CTGTCAGGATTCTGCTGAACAAGAAAACGGCTCATTCCTTTGAGCAGGTCCTCACCGATATCACCGATGCCATCAAGCTGGACTCGGGAG
TGGTGAAACGCCTGTACACGTTGGATGGGAAACAGGTGATGTGCCTTCAGGACTTTTTTGGTGATGATGACATTTTTATTGCATGTGGAC
CGGAGAAGTTCCGTTACCAGGATGATTTCTTGCTAGATGAAAGTGAATGTCGAGTGGTAAAGTCCACTTCTTACACCAAAATAGCTTCAT
CATCCCGCAGGAGCACCACCAAGAGCCCAGGACCGTCCAGGCGTAGCAAGTCCCCTGCCTCCACCAGCTCAGGATTTAGAAGAATTCTGC
TTTAAGTTTTGCATCAATCATTTGACAGAAGTTACACAGACTGCAGCATTTTGGCAAATGGATGGCCCTCTGCTAAAGGAATTCATTGCT
AAAGCCAGTAAATGTGGAGCCTTTAAGAACTGAAGCGCAAGGCTGCTGGGTTCTGTGTGAGTGCTCTGGGGCACTGTTGAGGATGTGTCC
AGTTTGTGCTCTACGGGTGATGTGATTCTGCAGGTAAAAGACCATCAGGTTGTTTTTTTCCACATCTGGGACACAGTTGTTTGTGTAGGA
ACATAACAAGGGTGTACGGCTTTTCTTGAGCCCATTTTAAACAACCCTTGTTTCCAGATAAGTGTATTTTAAATGTGACCTTTCGTAAAT
TTGGGCTGGAACATGTAAAAGGGTGAAAGTTAGTCGTTTTTGGTCTTCTTTTCATTTTTGATTAGAGGAACTTCTGAACTTGGAAAGGGG
AAGTTGGCAGCAACTCTCCTGGGCCACGTATCAACAATCTTCTGACAGCAGGAGCAGTGATAGTTGGGGAATTGTGAGATGAATGGAGAG
GCCCCATCGTGAATTAAAGATGCTGACCTGGGGATTGTTAAGTGCTGCCTTAGTTGCTAGTTTAGTAGCCTTACTGTGAAGGAATAATTA
AGATTGTTTCAGACTTTTGTTTGTGTGCTTGCGTTGATGACTTTTTTAACTTCAAGATAAATCAAAGTAATAAGTTTAACGTATATTAAA
CCTGTTGAAATGATAATTATGTAAAGATAAATATTCTAGGTTAGTCAAGATTTCTCTTAAGATTTAAGTGCATAAAGAATAGTAATTTAG
AAGTATCCGTGAAAAGTTGATAATGAAAGAAATTTGATGAAGGTGAATATTTTATAAATTAGAATCTCCACTACTTATCCAATGGTGTTT
TATTTCATTAAGGTAGAACTTGAGAACTCAAGTTTAAATTGTCCCCCACCACCTTCTTCTATAAATGCAAACTTAAGAGGAAAATAATGA
CATGTATAGTATACTCTTGCCTTCCTAAATTATGACTGCTGAATCATCATATCTACTATATATGACTGGAAGAAGTGGTTCTTCAAGTCA
ACCCTCTTACAAGACTTAGTGGAATTTGCTTTATCTACTTTAGGCCAAATCCATCACACATTGGCTTATGTGAAACTTTATCATCTTTCA
CTTTTGGTTTTCCTCTGTTTTTAAACATCTTAGGTATAACAGCACAATTTCACCTTGAAAAAGCACCAAAATTATGGTGTTCCTGAAAAG
ATCCTATTAAAAGACAGTAGTTTATTTGAACTGGTTATGGAAGGTGACTTTGGGATGTAAGAGTGTTCAACTGTGAGTTTCATCATGTGT
GTCCGTTGAGCTTGCTTTTAAGAGCAATGTTTTGCTTTGCTCTCTGGTCCATGAACTCATTTCCATTTGAGTGAGTTCCCTTAGTGAATT
TTGTCTCCTGCTTGGAAAGTCTCTCTTCTGAACCTGGAGCCTGAATACATTTTCAGAGCCAAATTACAAGTGGGTGAAGACATGCTACAA
CTACTATTTTTAGCAATGTTTTTAAATTTGTGTCTATTGGGGTGGGAAGGGGAGTGAGGCCCTAAAGATAGGAATTCACTGATAGCTGAA
ATAGATACAAGCCTAGGAGCCCCAGCCCCCTTTTCTTGACCATATCACAAGTGATTGAAGCCCAGTGAATTAGTCGGTTAGAATTCGTTC
TACAACATGATAGAACTTTTCTTACTAGCTTCAGAAATGCACATTGATTTGTGCTATGATGGGTGGTGTTTGTAACAATCACTGTTCTAT
AGGCTTATGATCTGAGCAAAATGTGAACTTCAGTATGTTTACTATTGCTCTTACTTGAAAACTTTTTTTCAAAAAAAGCACAAATTAAAG
TAGTAAATTCATATCCATAGATAGTTCATTCATTCAACAAATATTTACCAAGTTCCTAATATAAGTGAAGGACCACTTCTCATATTAGAT
TACTAAGTCATTTGTATGAATATGTGTGGCAGTGAAGAGAACAGGTCTTTCAAAAAGCATTTGATTATTTTTTTTAAATACACTCTCTTA
TTTTTCTACTTGTTTTTTTGTTAATCATAGCAGGATATGACAACTCTTATTTGAATTGATTTTTTCATCTAATGTAATAATGGAAGCCAA
AGTATTCATATTTCTTAAGATAGCCCTAAATGTACTCTTGAACTTCTTACTGGAACAATGTTTGATACTCTAGTATGTAAGCTGTATTTA

>21622_21622_1_DCLK1-RCBTB1_DCLK1_chr13_36445361_ENST00000255448_RCBTB1_chr13_50108398_ENST00000378302_length(amino acids)=324AA_BP=
MKSIMSFGRDMELEHFDERDKAQRYSRGSRVNGLPSPTHSAHCSFYRTRTLQTLSSEKKAKKVRFYRNGDRYFKGIVYAISPDRFRSFEA
LLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIEPFKKLEYTKNVNPNWSVNVKTTSASRAVSSLATAKGSPSEV
RENKDFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLQDFFGDDDIFIACGPEKFRYQ

--------------------------------------------------------------
>21622_21622_2_DCLK1-RCBTB1_DCLK1_chr13_36445361_ENST00000360631_RCBTB1_chr13_50108398_ENST00000378302_length(transcript)=3461nt_BP=1152nt
GCACATCCCTGCACTAGTGGCCGCAACCGAGGCGCCGCGCTCCAGCAGCTGCTGCCGCCCAGCCCGGCCCCGCCGCCGCCCCCCAGCCCT
GCAGCCCCGCAGCCCCGGCCGCGCCCAGCCCGGCGAGGACAGCACCAGGAGGCGGCCCCCAGCGCGGCCACAAAGACCCCCGGCGGCGTC
TCTCCGCGGACCGGTCCTACTTGAAGTCCATCATGTCCTTCGGCAGAGACATGGAGCTGGAGCACTTCGACGAGCGGGATAAGGCGCAGA
GATACAGCCGAGGGTCGCGGGTGAACGGCCTGCCGAGCCCGACGCACAGCGCCCACTGCAGCTTCTACCGCACCCGCACGCTGCAGACGC
TCAGCTCCGAGAAGAAGGCCAAGAAAGTTCGTTTCTATCGAAACGGAGATCGATACTTCAAAGGGATTGTGTATGCCATCTCCCCAGACC
GGTTCCGATCTTTTGAGGCCCTGCTGGCTGATTTGACCCGAACTCTGTCGGATAACGTGAATTTGCCCCAGGGAGTGAGAACAATCTACA
CCATTGATGGGCTCAAGAAGATTTCCAGCCTGGACCAACTGGTGGAAGGAGAGAGTTATGTATGTGGCTCCATAGAGCCCTTCAAGAAAC
TGGAGTACACCAAGAATGTGAACCCCAACTGGTCGGTGAACGTCAAGACCACCTCGGCTTCTCGGGCAGTGTCTTCACTGGCCACTGCCA
AAGGAAGCCCTTCAGAGGTGCGAGAGAATAAGGATTTCATTCGGCCCAAGCTGGTCACCATCATCAGAAGTGGCGTGAAGCCACGGAAAG
CTGTCAGGATTCTGCTGAACAAGAAAACGGCTCATTCCTTTGAGCAGGTCCTCACCGATATCACCGATGCCATCAAGCTGGACTCGGGAG
TGGTGAAACGCCTGTACACGTTGGATGGGAAACAGGTGATGTGCCTTCAGGACTTTTTTGGTGATGATGACATTTTTATTGCATGTGGAC
CGGAGAAGTTCCGTTACCAGGATGATTTCTTGCTAGATGAAAGTGAATGTCGAGTGGTAAAGTCCACTTCTTACACCAAAATAGCTTCAT
CATCCCGCAGGAGCACCACCAAGAGCCCAGGACCGTCCAGGCGTAGCAAGTCCCCTGCCTCCACCAGCTCAGGATTTAGAAGAATTCTGC
TTTAAGTTTTGCATCAATCATTTGACAGAAGTTACACAGACTGCAGCATTTTGGCAAATGGATGGCCCTCTGCTAAAGGAATTCATTGCT
AAAGCCAGTAAATGTGGAGCCTTTAAGAACTGAAGCGCAAGGCTGCTGGGTTCTGTGTGAGTGCTCTGGGGCACTGTTGAGGATGTGTCC
AGTTTGTGCTCTACGGGTGATGTGATTCTGCAGGTAAAAGACCATCAGGTTGTTTTTTTCCACATCTGGGACACAGTTGTTTGTGTAGGA
ACATAACAAGGGTGTACGGCTTTTCTTGAGCCCATTTTAAACAACCCTTGTTTCCAGATAAGTGTATTTTAAATGTGACCTTTCGTAAAT
TTGGGCTGGAACATGTAAAAGGGTGAAAGTTAGTCGTTTTTGGTCTTCTTTTCATTTTTGATTAGAGGAACTTCTGAACTTGGAAAGGGG
AAGTTGGCAGCAACTCTCCTGGGCCACGTATCAACAATCTTCTGACAGCAGGAGCAGTGATAGTTGGGGAATTGTGAGATGAATGGAGAG
GCCCCATCGTGAATTAAAGATGCTGACCTGGGGATTGTTAAGTGCTGCCTTAGTTGCTAGTTTAGTAGCCTTACTGTGAAGGAATAATTA
AGATTGTTTCAGACTTTTGTTTGTGTGCTTGCGTTGATGACTTTTTTAACTTCAAGATAAATCAAAGTAATAAGTTTAACGTATATTAAA
CCTGTTGAAATGATAATTATGTAAAGATAAATATTCTAGGTTAGTCAAGATTTCTCTTAAGATTTAAGTGCATAAAGAATAGTAATTTAG
AAGTATCCGTGAAAAGTTGATAATGAAAGAAATTTGATGAAGGTGAATATTTTATAAATTAGAATCTCCACTACTTATCCAATGGTGTTT
TATTTCATTAAGGTAGAACTTGAGAACTCAAGTTTAAATTGTCCCCCACCACCTTCTTCTATAAATGCAAACTTAAGAGGAAAATAATGA
CATGTATAGTATACTCTTGCCTTCCTAAATTATGACTGCTGAATCATCATATCTACTATATATGACTGGAAGAAGTGGTTCTTCAAGTCA
ACCCTCTTACAAGACTTAGTGGAATTTGCTTTATCTACTTTAGGCCAAATCCATCACACATTGGCTTATGTGAAACTTTATCATCTTTCA
CTTTTGGTTTTCCTCTGTTTTTAAACATCTTAGGTATAACAGCACAATTTCACCTTGAAAAAGCACCAAAATTATGGTGTTCCTGAAAAG
ATCCTATTAAAAGACAGTAGTTTATTTGAACTGGTTATGGAAGGTGACTTTGGGATGTAAGAGTGTTCAACTGTGAGTTTCATCATGTGT
GTCCGTTGAGCTTGCTTTTAAGAGCAATGTTTTGCTTTGCTCTCTGGTCCATGAACTCATTTCCATTTGAGTGAGTTCCCTTAGTGAATT
TTGTCTCCTGCTTGGAAAGTCTCTCTTCTGAACCTGGAGCCTGAATACATTTTCAGAGCCAAATTACAAGTGGGTGAAGACATGCTACAA
CTACTATTTTTAGCAATGTTTTTAAATTTGTGTCTATTGGGGTGGGAAGGGGAGTGAGGCCCTAAAGATAGGAATTCACTGATAGCTGAA
ATAGATACAAGCCTAGGAGCCCCAGCCCCCTTTTCTTGACCATATCACAAGTGATTGAAGCCCAGTGAATTAGTCGGTTAGAATTCGTTC
TACAACATGATAGAACTTTTCTTACTAGCTTCAGAAATGCACATTGATTTGTGCTATGATGGGTGGTGTTTGTAACAATCACTGTTCTAT
AGGCTTATGATCTGAGCAAAATGTGAACTTCAGTATGTTTACTATTGCTCTTACTTGAAAACTTTTTTTCAAAAAAAGCACAAATTAAAG
TAGTAAATTCATATCCATAGATAGTTCATTCATTCAACAAATATTTACCAAGTTCCTAATATAAGTGAAGGACCACTTCTCATATTAGAT
TACTAAGTCATTTGTATGAATATGTGTGGCAGTGAAGAGAACAGGTCTTTCAAAAAGCATTTGATTATTTTTTTTAAATACACTCTCTTA
TTTTTCTACTTGTTTTTTTGTTAATCATAGCAGGATATGACAACTCTTATTTGAATTGATTTTTTCATCTAATGTAATAATGGAAGCCAA
AGTATTCATATTTCTTAAGATAGCCCTAAATGTACTCTTGAACTTCTTACTGGAACAATGTTTGATACTCTAGTATGTAAGCTGTATTTA

>21622_21622_2_DCLK1-RCBTB1_DCLK1_chr13_36445361_ENST00000360631_RCBTB1_chr13_50108398_ENST00000378302_length(amino acids)=324AA_BP=
MKSIMSFGRDMELEHFDERDKAQRYSRGSRVNGLPSPTHSAHCSFYRTRTLQTLSSEKKAKKVRFYRNGDRYFKGIVYAISPDRFRSFEA
LLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIEPFKKLEYTKNVNPNWSVNVKTTSASRAVSSLATAKGSPSEV
RENKDFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLQDFFGDDDIFIACGPEKFRYQ

--------------------------------------------------------------
>21622_21622_3_DCLK1-RCBTB1_DCLK1_chr13_36445361_ENST00000379892_RCBTB1_chr13_50108398_ENST00000378302_length(transcript)=3461nt_BP=1152nt
GCACATCCCTGCACTAGTGGCCGCAACCGAGGCGCCGCGCTCCAGCAGCTGCTGCCGCCCAGCCCGGCCCCGCCGCCGCCCCCCAGCCCT
GCAGCCCCGCAGCCCCGGCCGCGCCCAGCCCGGCGAGGACAGCACCAGGAGGCGGCCCCCAGCGCGGCCACAAAGACCCCCGGCGGCGTC
TCTCCGCGGACCGGTCCTACTTGAAGTCCATCATGTCCTTCGGCAGAGACATGGAGCTGGAGCACTTCGACGAGCGGGATAAGGCGCAGA
GATACAGCCGAGGGTCGCGGGTGAACGGCCTGCCGAGCCCGACGCACAGCGCCCACTGCAGCTTCTACCGCACCCGCACGCTGCAGACGC
TCAGCTCCGAGAAGAAGGCCAAGAAAGTTCGTTTCTATCGAAACGGAGATCGATACTTCAAAGGGATTGTGTATGCCATCTCCCCAGACC
GGTTCCGATCTTTTGAGGCCCTGCTGGCTGATTTGACCCGAACTCTGTCGGATAACGTGAATTTGCCCCAGGGAGTGAGAACAATCTACA
CCATTGATGGGCTCAAGAAGATTTCCAGCCTGGACCAACTGGTGGAAGGAGAGAGTTATGTATGTGGCTCCATAGAGCCCTTCAAGAAAC
TGGAGTACACCAAGAATGTGAACCCCAACTGGTCGGTGAACGTCAAGACCACCTCGGCTTCTCGGGCAGTGTCTTCACTGGCCACTGCCA
AAGGAAGCCCTTCAGAGGTGCGAGAGAATAAGGATTTCATTCGGCCCAAGCTGGTCACCATCATCAGAAGTGGCGTGAAGCCACGGAAAG
CTGTCAGGATTCTGCTGAACAAGAAAACGGCTCATTCCTTTGAGCAGGTCCTCACCGATATCACCGATGCCATCAAGCTGGACTCGGGAG
TGGTGAAACGCCTGTACACGTTGGATGGGAAACAGGTGATGTGCCTTCAGGACTTTTTTGGTGATGATGACATTTTTATTGCATGTGGAC
CGGAGAAGTTCCGTTACCAGGATGATTTCTTGCTAGATGAAAGTGAATGTCGAGTGGTAAAGTCCACTTCTTACACCAAAATAGCTTCAT
CATCCCGCAGGAGCACCACCAAGAGCCCAGGACCGTCCAGGCGTAGCAAGTCCCCTGCCTCCACCAGCTCAGGATTTAGAAGAATTCTGC
TTTAAGTTTTGCATCAATCATTTGACAGAAGTTACACAGACTGCAGCATTTTGGCAAATGGATGGCCCTCTGCTAAAGGAATTCATTGCT
AAAGCCAGTAAATGTGGAGCCTTTAAGAACTGAAGCGCAAGGCTGCTGGGTTCTGTGTGAGTGCTCTGGGGCACTGTTGAGGATGTGTCC
AGTTTGTGCTCTACGGGTGATGTGATTCTGCAGGTAAAAGACCATCAGGTTGTTTTTTTCCACATCTGGGACACAGTTGTTTGTGTAGGA
ACATAACAAGGGTGTACGGCTTTTCTTGAGCCCATTTTAAACAACCCTTGTTTCCAGATAAGTGTATTTTAAATGTGACCTTTCGTAAAT
TTGGGCTGGAACATGTAAAAGGGTGAAAGTTAGTCGTTTTTGGTCTTCTTTTCATTTTTGATTAGAGGAACTTCTGAACTTGGAAAGGGG
AAGTTGGCAGCAACTCTCCTGGGCCACGTATCAACAATCTTCTGACAGCAGGAGCAGTGATAGTTGGGGAATTGTGAGATGAATGGAGAG
GCCCCATCGTGAATTAAAGATGCTGACCTGGGGATTGTTAAGTGCTGCCTTAGTTGCTAGTTTAGTAGCCTTACTGTGAAGGAATAATTA
AGATTGTTTCAGACTTTTGTTTGTGTGCTTGCGTTGATGACTTTTTTAACTTCAAGATAAATCAAAGTAATAAGTTTAACGTATATTAAA
CCTGTTGAAATGATAATTATGTAAAGATAAATATTCTAGGTTAGTCAAGATTTCTCTTAAGATTTAAGTGCATAAAGAATAGTAATTTAG
AAGTATCCGTGAAAAGTTGATAATGAAAGAAATTTGATGAAGGTGAATATTTTATAAATTAGAATCTCCACTACTTATCCAATGGTGTTT
TATTTCATTAAGGTAGAACTTGAGAACTCAAGTTTAAATTGTCCCCCACCACCTTCTTCTATAAATGCAAACTTAAGAGGAAAATAATGA
CATGTATAGTATACTCTTGCCTTCCTAAATTATGACTGCTGAATCATCATATCTACTATATATGACTGGAAGAAGTGGTTCTTCAAGTCA
ACCCTCTTACAAGACTTAGTGGAATTTGCTTTATCTACTTTAGGCCAAATCCATCACACATTGGCTTATGTGAAACTTTATCATCTTTCA
CTTTTGGTTTTCCTCTGTTTTTAAACATCTTAGGTATAACAGCACAATTTCACCTTGAAAAAGCACCAAAATTATGGTGTTCCTGAAAAG
ATCCTATTAAAAGACAGTAGTTTATTTGAACTGGTTATGGAAGGTGACTTTGGGATGTAAGAGTGTTCAACTGTGAGTTTCATCATGTGT
GTCCGTTGAGCTTGCTTTTAAGAGCAATGTTTTGCTTTGCTCTCTGGTCCATGAACTCATTTCCATTTGAGTGAGTTCCCTTAGTGAATT
TTGTCTCCTGCTTGGAAAGTCTCTCTTCTGAACCTGGAGCCTGAATACATTTTCAGAGCCAAATTACAAGTGGGTGAAGACATGCTACAA
CTACTATTTTTAGCAATGTTTTTAAATTTGTGTCTATTGGGGTGGGAAGGGGAGTGAGGCCCTAAAGATAGGAATTCACTGATAGCTGAA
ATAGATACAAGCCTAGGAGCCCCAGCCCCCTTTTCTTGACCATATCACAAGTGATTGAAGCCCAGTGAATTAGTCGGTTAGAATTCGTTC
TACAACATGATAGAACTTTTCTTACTAGCTTCAGAAATGCACATTGATTTGTGCTATGATGGGTGGTGTTTGTAACAATCACTGTTCTAT
AGGCTTATGATCTGAGCAAAATGTGAACTTCAGTATGTTTACTATTGCTCTTACTTGAAAACTTTTTTTCAAAAAAAGCACAAATTAAAG
TAGTAAATTCATATCCATAGATAGTTCATTCATTCAACAAATATTTACCAAGTTCCTAATATAAGTGAAGGACCACTTCTCATATTAGAT
TACTAAGTCATTTGTATGAATATGTGTGGCAGTGAAGAGAACAGGTCTTTCAAAAAGCATTTGATTATTTTTTTTAAATACACTCTCTTA
TTTTTCTACTTGTTTTTTTGTTAATCATAGCAGGATATGACAACTCTTATTTGAATTGATTTTTTCATCTAATGTAATAATGGAAGCCAA
AGTATTCATATTTCTTAAGATAGCCCTAAATGTACTCTTGAACTTCTTACTGGAACAATGTTTGATACTCTAGTATGTAAGCTGTATTTA

>21622_21622_3_DCLK1-RCBTB1_DCLK1_chr13_36445361_ENST00000379892_RCBTB1_chr13_50108398_ENST00000378302_length(amino acids)=324AA_BP=
MKSIMSFGRDMELEHFDERDKAQRYSRGSRVNGLPSPTHSAHCSFYRTRTLQTLSSEKKAKKVRFYRNGDRYFKGIVYAISPDRFRSFEA
LLADLTRTLSDNVNLPQGVRTIYTIDGLKKISSLDQLVEGESYVCGSIEPFKKLEYTKNVNPNWSVNVKTTSASRAVSSLATAKGSPSEV
RENKDFIRPKLVTIIRSGVKPRKAVRILLNKKTAHSFEQVLTDITDAIKLDSGVVKRLYTLDGKQVMCLQDFFGDDDIFIACGPEKFRYQ

--------------------------------------------------------------

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Fusion Gene PPI Analysis for DCLK1-RCBTB1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for DCLK1-RCBTB1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for DCLK1-RCBTB1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneDCLK1C0005586Bipolar Disorder1PSYGENET
HgeneDCLK1C0009402Colorectal Carcinoma1CTD_human
HgeneDCLK1C0009404Colorectal Neoplasms1CTD_human
HgeneDCLK1C0036341Schizophrenia1PSYGENET
TgeneC0036341Schizophrenia1PSYGENET
TgeneC0154832Exudative retinopathy1GENOMICS_ENGLAND
TgeneC0339539Familial Exudative Vitreoretinopathy1GENOMICS_ENGLAND
TgeneC1867332Reticular Dystrophy Of Retinal Pigment Epithelium1ORPHANET
TgeneC4310680RETINAL DYSTROPHY WITH OR WITHOUT EXTRAOCULAR ANOMALIES1CTD_human;GENOMICS_ENGLAND;UNIPROT