Fusion Gene Studies
in Kim Lab

FusionBase FusionGDB FusionGDB2 FusionPDB FusionNeoAntigen FusionAI FusionNW FGviewer Publication Contact
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Center for Computational Systems Medicine
leaf

Fusion Gene Summary

leaf

Fusion Gene ORF analysis

leaf

Fusion Genomic Features

leaf

Fusion Protein Features

leaf

Fusion Gene Sequence

leaf

Fusion Gene PPI analysis

leaf

Related Drugs

leaf

Related Diseases

Fusion gene:GPR56-MT1F (FusionGDB2 ID:HG9289TG4494)

Fusion Gene Summary for GPR56-MT1F

check button Fusion gene summary
Fusion gene informationFusion gene name: GPR56-MT1F
Fusion gene ID: hg9289tg4494
HgeneTgene
Gene symbol

GPR56

MT1F

Gene ID

9289

4494

Gene nameadhesion G protein-coupled receptor G1metallothionein 1F
SynonymsBFPP|BPPR|GPR56|TM7LN4|TM7XN1MT1
Cytomap('GPR56')('MT1F')

16q21

16q13

Type of geneprotein-codingprotein-coding
Descriptionadhesion G-protein coupled receptor G17-transmembrane protein with no EGF-like N-terminal domains-1G protein-coupled receptor 56testicular tissue protein Li 77metallothionein-1FMT-1FMT-IFmetallothionein 1F (functional)metallothionein-IF
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000564912, ENST00000379694, 
ENST00000379696, ENST00000388812, 
ENST00000388813, ENST00000456916, 
ENST00000538815, ENST00000540164, 
ENST00000562558, ENST00000562631, 
ENST00000567835, ENST00000568908, 
ENST00000568909, ENST00000544297, 
Fusion gene scores* DoF score5 X 6 X 4=1203 X 5 X 2=30
# samples 63
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(3/30*10)=0
Context

PubMed: GPR56 [Title/Abstract] AND MT1F [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointGPR56(57685294)-MT1F(56692943), # samples:1
GPR56(57685288)-MT1F(56692937), # samples:1
GPR56(57684261)-MT1F(56692983), # samples:1
Anticipated loss of major functional domain due to fusion event.GPR56-MT1F seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGPR56

GO:0001525

angiogenesis

21724588

HgeneGPR56

GO:0007155

cell adhesion

27068534

HgeneGPR56

GO:0007266

Rho protein signal transduction

21708946

HgeneGPR56

GO:0008285

negative regulation of cell proliferation

16757564

HgeneGPR56

GO:0010573

vascular endothelial growth factor production

21724588

HgeneGPR56

GO:0016477

cell migration

27068534

HgeneGPR56

GO:0045785

positive regulation of cell adhesion

21349848

HgeneGPR56

GO:0070528

protein kinase C signaling

21724588



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-EO-A1Y8-01AGPR56chr16

57684261

+MT1Fchr16

56692983

+
ChimerDB4UCECTCGA-EO-A1Y8-01AGPR56chr16

57685288

+MT1Fchr16

56692937

+
ChimerDB4UCECTCGA-EO-A1Y8-01AGPR56chr16

57685294

+MT1Fchr16

56692943

+


Top

Fusion Gene ORF analysis for GPR56-MT1F

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000564912ENST00000334350GPR56chr16

57684261

+MT1Fchr16

56692983

+
3UTR-3CDSENST00000564912ENST00000394501GPR56chr16

57684261

+MT1Fchr16

56692983

+
3UTR-3UTRENST00000564912ENST00000568475GPR56chr16

57684261

+MT1Fchr16

56692983

+
3UTR-intronENST00000564912ENST00000334350GPR56chr16

57685288

+MT1Fchr16

56692937

+
3UTR-intronENST00000564912ENST00000334350GPR56chr16

57685294

+MT1Fchr16

56692943

+
3UTR-intronENST00000564912ENST00000394501GPR56chr16

57685288

+MT1Fchr16

56692937

+
3UTR-intronENST00000564912ENST00000394501GPR56chr16

57685294

+MT1Fchr16

56692943

+
3UTR-intronENST00000564912ENST00000567672GPR56chr16

57684261

+MT1Fchr16

56692983

+
3UTR-intronENST00000564912ENST00000567672GPR56chr16

57685288

+MT1Fchr16

56692937

+
3UTR-intronENST00000564912ENST00000567672GPR56chr16

57685294

+MT1Fchr16

56692943

+
3UTR-intronENST00000564912ENST00000568475GPR56chr16

57685288

+MT1Fchr16

56692937

+
3UTR-intronENST00000564912ENST00000568475GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-3UTRENST00000379694ENST00000568475GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-3UTRENST00000379696ENST00000568475GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-3UTRENST00000388812ENST00000568475GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-3UTRENST00000388813ENST00000568475GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-3UTRENST00000456916ENST00000568475GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-3UTRENST00000538815ENST00000568475GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-3UTRENST00000540164ENST00000568475GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-3UTRENST00000562558ENST00000568475GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-3UTRENST00000562631ENST00000568475GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-3UTRENST00000567835ENST00000568475GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-3UTRENST00000568908ENST00000568475GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-3UTRENST00000568909ENST00000568475GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-intronENST00000379694ENST00000567672GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-intronENST00000379696ENST00000334350GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000379696ENST00000334350GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000379696ENST00000394501GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000379696ENST00000394501GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000379696ENST00000567672GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-intronENST00000379696ENST00000567672GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000379696ENST00000567672GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000379696ENST00000568475GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000379696ENST00000568475GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000388812ENST00000334350GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000388812ENST00000334350GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000388812ENST00000394501GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000388812ENST00000394501GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000388812ENST00000567672GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-intronENST00000388812ENST00000567672GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000388812ENST00000567672GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000388812ENST00000568475GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000388812ENST00000568475GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000388813ENST00000334350GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000388813ENST00000334350GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000388813ENST00000394501GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000388813ENST00000394501GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000388813ENST00000567672GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-intronENST00000388813ENST00000567672GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000388813ENST00000567672GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000388813ENST00000568475GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000388813ENST00000568475GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000456916ENST00000334350GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000456916ENST00000334350GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000456916ENST00000394501GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000456916ENST00000394501GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000456916ENST00000567672GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-intronENST00000456916ENST00000567672GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000456916ENST00000567672GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000456916ENST00000568475GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000456916ENST00000568475GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000538815ENST00000334350GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000538815ENST00000334350GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000538815ENST00000394501GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000538815ENST00000394501GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000538815ENST00000567672GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-intronENST00000538815ENST00000567672GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000538815ENST00000567672GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000538815ENST00000568475GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000538815ENST00000568475GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000540164ENST00000334350GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000540164ENST00000334350GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000540164ENST00000394501GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000540164ENST00000394501GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000540164ENST00000567672GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-intronENST00000540164ENST00000567672GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000540164ENST00000567672GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000540164ENST00000568475GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000540164ENST00000568475GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000562558ENST00000334350GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000562558ENST00000334350GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000562558ENST00000394501GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000562558ENST00000394501GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000562558ENST00000567672GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-intronENST00000562558ENST00000567672GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000562558ENST00000567672GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000562558ENST00000568475GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000562558ENST00000568475GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000562631ENST00000334350GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000562631ENST00000334350GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000562631ENST00000394501GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000562631ENST00000394501GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000562631ENST00000567672GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-intronENST00000562631ENST00000567672GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000562631ENST00000567672GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000562631ENST00000568475GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000562631ENST00000568475GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000567835ENST00000334350GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000567835ENST00000334350GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000567835ENST00000394501GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000567835ENST00000394501GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000567835ENST00000567672GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-intronENST00000567835ENST00000567672GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000567835ENST00000567672GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000567835ENST00000568475GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000567835ENST00000568475GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000568908ENST00000334350GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000568908ENST00000334350GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000568908ENST00000394501GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000568908ENST00000394501GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000568908ENST00000567672GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-intronENST00000568908ENST00000567672GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000568908ENST00000567672GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000568908ENST00000568475GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000568908ENST00000568475GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000568909ENST00000334350GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000568909ENST00000334350GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000568909ENST00000394501GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000568909ENST00000394501GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000568909ENST00000567672GPR56chr16

57684261

+MT1Fchr16

56692983

+
5CDS-intronENST00000568909ENST00000567672GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000568909ENST00000567672GPR56chr16

57685294

+MT1Fchr16

56692943

+
5CDS-intronENST00000568909ENST00000568475GPR56chr16

57685288

+MT1Fchr16

56692937

+
5CDS-intronENST00000568909ENST00000568475GPR56chr16

57685294

+MT1Fchr16

56692943

+
5UTR-3CDSENST00000544297ENST00000334350GPR56chr16

57684261

+MT1Fchr16

56692983

+
5UTR-3CDSENST00000544297ENST00000394501GPR56chr16

57684261

+MT1Fchr16

56692983

+
5UTR-3UTRENST00000544297ENST00000568475GPR56chr16

57684261

+MT1Fchr16

56692983

+
5UTR-intronENST00000544297ENST00000334350GPR56chr16

57685288

+MT1Fchr16

56692937

+
5UTR-intronENST00000544297ENST00000334350GPR56chr16

57685294

+MT1Fchr16

56692943

+
5UTR-intronENST00000544297ENST00000394501GPR56chr16

57685288

+MT1Fchr16

56692937

+
5UTR-intronENST00000544297ENST00000394501GPR56chr16

57685294

+MT1Fchr16

56692943

+
5UTR-intronENST00000544297ENST00000567672GPR56chr16

57684261

+MT1Fchr16

56692983

+
5UTR-intronENST00000544297ENST00000567672GPR56chr16

57685288

+MT1Fchr16

56692937

+
5UTR-intronENST00000544297ENST00000567672GPR56chr16

57685294

+MT1Fchr16

56692943

+
5UTR-intronENST00000544297ENST00000568475GPR56chr16

57685288

+MT1Fchr16

56692937

+
5UTR-intronENST00000544297ENST00000568475GPR56chr16

57685294

+MT1Fchr16

56692943

+
Frame-shiftENST00000379694ENST00000334350GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000379694ENST00000394501GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000379696ENST00000334350GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000379696ENST00000394501GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000388812ENST00000334350GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000388812ENST00000394501GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000388813ENST00000334350GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000388813ENST00000394501GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000456916ENST00000334350GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000456916ENST00000394501GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000538815ENST00000334350GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000538815ENST00000394501GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000540164ENST00000334350GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000540164ENST00000394501GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000562558ENST00000334350GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000562558ENST00000394501GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000562631ENST00000334350GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000562631ENST00000394501GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000567835ENST00000334350GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000567835ENST00000394501GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000568908ENST00000334350GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000568908ENST00000394501GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000568909ENST00000334350GPR56chr16

57684261

+MT1Fchr16

56692983

+
Frame-shiftENST00000568909ENST00000394501GPR56chr16

57684261

+MT1Fchr16

56692983

+
intron-intronENST00000379694ENST00000334350GPR56chr16

57685288

+MT1Fchr16

56692937

+
intron-intronENST00000379694ENST00000334350GPR56chr16

57685294

+MT1Fchr16

56692943

+
intron-intronENST00000379694ENST00000394501GPR56chr16

57685288

+MT1Fchr16

56692937

+
intron-intronENST00000379694ENST00000394501GPR56chr16

57685294

+MT1Fchr16

56692943

+
intron-intronENST00000379694ENST00000567672GPR56chr16

57685288

+MT1Fchr16

56692937

+
intron-intronENST00000379694ENST00000567672GPR56chr16

57685294

+MT1Fchr16

56692943

+
intron-intronENST00000379694ENST00000568475GPR56chr16

57685288

+MT1Fchr16

56692937

+
intron-intronENST00000379694ENST00000568475GPR56chr16

57685294

+MT1Fchr16

56692943

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

Top

Fusion Genomic Features for GPR56-MT1F


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
GPR56chr1657684263+MT1Fchr1656692984+0.0006213680.99937856
GPR56chr1657684263+MT1Fchr1656692984+0.0006213680.99937856


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

Top

Fusion Protein Features for GPR56-MT1F


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:57685294/:56692943)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


Top

Fusion Gene Sequence for GPR56-MT1F


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

Top

Fusion Gene PPI Analysis for GPR56-MT1F


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs for GPR56-MT1F


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

Top

Related Diseases for GPR56-MT1F


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC2239176Liver carcinoma1CTD_human