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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CD83-LAMA2 (FusionGDB2 ID:HG9308TG3908)

Fusion Gene Summary for CD83-LAMA2

check button Fusion gene summary
Fusion gene informationFusion gene name: CD83-LAMA2
Fusion gene ID: hg9308tg3908
HgeneTgene
Gene symbol

CD83

LAMA2

Gene ID

9308

3908

Gene nameCD83 moleculelaminin subunit alpha 2
SynonymsBL11|HB15LAMM|MDC1A
Cytomap('CD83')('LAMA2')

6p23

6q22.33

Type of geneprotein-codingprotein-coding
DescriptionCD83 antigenB-cell activation proteinCD83 antigen (activated B lymphocytes, immunoglobulin superfamily)cell surface protein HB15cell-surface glycoproteinhCD83laminin subunit alpha-2laminin M chainlaminin, alpha 2laminin-12 subunit alphalaminin-2 subunit alphalaminin-4 subunit alphamerosin heavy chainmutant laminin subunit alpha 2
Modification date2020031320200328
UniProtAcc

Q01151

.
Ensembl transtripts involved in fusion geneENST00000379153, 
Fusion gene scores* DoF score4 X 4 X 4=6416 X 17 X 7=1904
# samples 417
** MAII scorelog2(4/64*10)=-0.678071905112638
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(17/1904*10)=-3.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CD83 [Title/Abstract] AND LAMA2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCD83(14118296)-LAMA2(129663488), # samples:3
Anticipated loss of major functional domain due to fusion event.CD83-LAMA2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CD83-LAMA2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CD83-LAMA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CD83-LAMA2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across CD83 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across LAMA2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A1FD-01ACD83chr6

14118296

-LAMA2chr6

129663488

+
ChimerDB4BRCATCGA-BH-A1FD-01ACD83chr6

14118296

+LAMA2chr6

129663488

+


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Fusion Gene ORF analysis for CD83-LAMA2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000379153ENST00000498257CD83chr6

14118296

+LAMA2chr6

129663488

+
In-frameENST00000379153ENST00000421865CD83chr6

14118296

+LAMA2chr6

129663488

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000379153CD83chr614118296+ENST00000421865LAMA2chr6129663488+560432417153811736

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379153ENST00000421865CD83chr614118296+LAMA2chr6129663488+0.0007570630.9992429

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Fusion Genomic Features for CD83-LAMA2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CD83chr614118296+LAMA2chr6129663487+1.31E-070.9999999
CD83chr614118296+LAMA2chr6129663487+1.31E-070.9999999

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CD83-LAMA2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:14118296/chr6:129663488)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CD83

Q01151

.
FUNCTION: May play a significant role in antigen presentation or the cellular interactions that follow lymphocyte activation.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneLAMA2chr6:14118296chr6:129663488ENST0000042186528651630_215014373123.0Coiled coilOntology_term=ECO:0000255
TgeneLAMA2chr6:14118296chr6:129663488ENST0000042186528651469_152614373123.0DomainLaminin EGF-like 16
TgeneLAMA2chr6:14118296chr6:129663488ENST0000042186528651527_157314373123.0DomainLaminin EGF-like 17
TgeneLAMA2chr6:14118296chr6:129663488ENST0000042186528652145_232814373123.0DomainLaminin G-like 1
TgeneLAMA2chr6:14118296chr6:129663488ENST0000042186528652340_252114373123.0DomainLaminin G-like 2
TgeneLAMA2chr6:14118296chr6:129663488ENST0000042186528652526_271014373123.0DomainLaminin G-like 3
TgeneLAMA2chr6:14118296chr6:129663488ENST0000042186528652763_293414373123.0DomainLaminin G-like 4
TgeneLAMA2chr6:14118296chr6:129663488ENST0000042186528652939_311014373123.0DomainLaminin G-like 5
TgeneLAMA2chr6:14118296chr6:129663488ENST0000042186528651574_214414373123.0RegionNote=Domain II and I

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD83chr6:14118296chr6:129663488ENST00000379153+2520_11451206.0DomainNote=Ig-like V-type
HgeneCD83chr6:14118296chr6:129663488ENST00000379153+25167_20551206.0Topological domainCytoplasmic
HgeneCD83chr6:14118296chr6:129663488ENST00000379153+2520_14451206.0Topological domainExtracellular
HgeneCD83chr6:14118296chr6:129663488ENST00000379153+25145_16651206.0TransmembraneHelical
TgeneLAMA2chr6:14118296chr6:129663488ENST0000042186528651014_105914373123.0DomainLaminin EGF-like 11
TgeneLAMA2chr6:14118296chr6:129663488ENST0000042186528651060_110514373123.0DomainLaminin EGF-like 12
TgeneLAMA2chr6:14118296chr6:129663488ENST0000042186528651106_116514373123.0DomainLaminin EGF-like 13
TgeneLAMA2chr6:14118296chr6:129663488ENST0000042186528651166_117514373123.0DomainLaminin EGF-like 14%3B first part
TgeneLAMA2chr6:14118296chr6:129663488ENST0000042186528651176_137914373123.0DomainLaminin IV type A 2
TgeneLAMA2chr6:14118296chr6:129663488ENST0000042186528651380_141914373123.0DomainLaminin EGF-like 14%3B second part
TgeneLAMA2chr6:14118296chr6:129663488ENST0000042186528651420_146814373123.0DomainLaminin EGF-like 15
TgeneLAMA2chr6:14118296chr6:129663488ENST000004218652865287_34314373123.0DomainLaminin EGF-like 1
TgeneLAMA2chr6:14118296chr6:129663488ENST000004218652865344_41314373123.0DomainLaminin EGF-like 2
TgeneLAMA2chr6:14118296chr6:129663488ENST00000421865286535_28614373123.0DomainLaminin N-terminal
TgeneLAMA2chr6:14118296chr6:129663488ENST000004218652865414_46814373123.0DomainLaminin EGF-like 3
TgeneLAMA2chr6:14118296chr6:129663488ENST000004218652865469_51714373123.0DomainLaminin EGF-like 4
TgeneLAMA2chr6:14118296chr6:129663488ENST000004218652865518_52714373123.0DomainLaminin EGF-like 5%3B first part
TgeneLAMA2chr6:14118296chr6:129663488ENST000004218652865531_72314373123.0DomainLaminin IV type A 1
TgeneLAMA2chr6:14118296chr6:129663488ENST000004218652865724_75614373123.0DomainLaminin EGF-like 5%3B second part
TgeneLAMA2chr6:14118296chr6:129663488ENST000004218652865757_80614373123.0DomainLaminin EGF-like 6
TgeneLAMA2chr6:14118296chr6:129663488ENST000004218652865807_86414373123.0DomainLaminin EGF-like 7
TgeneLAMA2chr6:14118296chr6:129663488ENST000004218652865865_91714373123.0DomainLaminin EGF-like 8
TgeneLAMA2chr6:14118296chr6:129663488ENST000004218652865918_96614373123.0DomainLaminin EGF-like 9
TgeneLAMA2chr6:14118296chr6:129663488ENST000004218652865967_101314373123.0DomainLaminin EGF-like 10


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Fusion Gene Sequence for CD83-LAMA2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>14699_14699_1_CD83-LAMA2_CD83_chr6_14118296_ENST00000379153_LAMA2_chr6_129663488_ENST00000421865_length(transcript)=5604nt_BP=324nt
GCGCCCCGGCCTAAGCGGGACTAGGAGGGCGCGCCACCCGCTTCCGCTGCCCGCCGGGGAATCCCCCGGGCTGGCGCGCAGGGAAGTTCC
CGAACGCGCGGGCATAAAAGGGCAGCCGGCGCCCGCGCGCCACAGCTCTGCAGCTCGTGGCAGCGGCGCAGCGCTCCAGCCATGTCGCGC
GGCCTCCAGCTTCTGCTCCTGAGCTGCGCCTACAGCCTGGCTCCCGCGACGCCGGAGGTGAAGGTGGCTTGCTCCGAAGATGTGGACTTG
CCCTGCACCGCCCCCTGGGATCCGCAGGTTCCCTACACGGTCTCCTGGGTCAAGAATTGTCAACATCACACTGCTGGTGACTTCTGTGAA
CGATGTGCTCTTGGATACTATGGAATTGTCAAGGGATTGCCAAATGACTGTCAGCAATGTGCCTGCCCTCTGATTTCTTCCAGTAACAAT
TTCAGCCCCTCTTGTGTCGCAGAAGGACTTGACGACTACCGCTGCACGGCTTGTCCACGGGGATATGAAGGCCAGTACTGTGAAAGGTGT
GCCCCTGGCTATACTGGCAGTCCAGGCAACCCTGGAGGCTCCTGCCAAGAATGTGAGTGTGATCCCTATGGCTCACTGCCTGTGCCCTGT
GACCCTGTCACAGGATTCTGCACGTGCCGACCTGGAGCCACGGGAAGGAAGTGTGACGGCTGCAAGCACTGGCATGCACGCGAGGGCTGG
GAGTGTGTTTTTTGTGGAGATGAGTGCACTGGCCTTCTTCTCGGTGACTTGGCTCGCCTGGAGCAGATGGTCATGAGCATCAACCTCACT
GGTCCGCTGCCTGCGCCATATAAAATGCTGTATGGTCTTGAAAATATGACTCAGGAGCTAAAGCACTTGCTGTCACCTCAGCGGGCCCCA
GAGAGGCTTATTCAGCTGGCAGAGGGCAATCTGAATACACTCGTGACCGAAATGAACGAGCTGCTGACCAGGGCTACCAAAGTGACAGCA
GATGGCGAGCAGACCGGACAGGATGCTGAGAGGACCAACACAAGAGCAAAGTCCCTGGGAGAATTCATTAAGGAGCTTGCCCGGGATGCA
GAAGCTGTAAATGAAAAAGCTATAAAACTAAATGAAACTCTAGGAACTCGAGACGAGGCCTTTGAGAGAAATTTGGAAGGGCTTCAGAAA
GAGATTGACCAGATGATTAAAGAACTGAGGAGGAAAAATCTAGAGACACAAAAGGAAATTGCTGAAGATGAGTTGGTAGCTGCAGAAGCC
CTTCTGAAAAAAGTGAAGAAGCTGTTTGGAGAGTCCCGGGGGGAAAATGAAGAAATGGAGAAGGATCTCCGGGAAAAACTGGCTGACTAC
AAAAACAAAGTTGATGATGCTTGGGACCTTTTGAGAGAAGCCACAGATAAAATCAGAGAAGCTAATCGCCTATTTGCAGTAAATCAGAAA
AACATGACTGCATTGGAGAAAAAGAAGGAGGCTGTTGAAAGCGGCAAACGACAAATTGAGAACACTTTAAAAGAGGGCAATGACATACTC
GATGAAGCCAACCGTCTTGCAGATGAAATCAACTCCATCATAGACTATGTTGAAGACATCCAAACTAAATTGCCACCTATGTCTGAGGAG
CTTAATGATAAAATAGATGACCTCTCCCAAGAAATAAAGGACAGGAAGCTTGCTGAGAAGGTGTCCCAGGCTGAGAGCCACGCAGCTCAG
TTGAATGACTCATCTGCTGTCCTTGATGGAATCCTTGATGAGGCTAAAAACATCTCCTTCAATGCCACTGCAGCCTTCAAAGCTTACAGC
AATATTAAGGACTATATTGATGAAGCTGAGAAAGTTGCCAAAGAAGCCAAAGATCTTGCACATGAAGCTACAAAACTGGCAACAGGTCCT
CGGGGTTTATTAAAGGAAGATGCCAAAGGCTGTCTTCAGAAAAGCTTCAGGATTCTTAACGAAGCCAAGAAGTTAGCAAATGATGTAAAA
GAAAATGAAGACCATCTAAATGGCTTAAAAACCAGGATAGAAAATGCTGATGCTAGAAATGGGGATCTCTTGAGAACTTTGAATGACACT
TTGGGAAAGTTATCAGCTATTCCAAATGATACAGCTGCTAAACTGCAAGCTGTTAAGGACAAAGCCAGACAAGCCAACGACACAGCTAAA
GATGTACTGGCACAGATTACAGAGCTCCACCAGAACCTCGATGGCCTGAAGAAGAATTACAATAAACTAGCAGACAGCGTCGCCAAAACG
AATGCTGTGGTTAAAGATCCTTCCAAGAACAAAATCATTGCCGATGCAGATGCCACTGTCAAAAATTTAGAACAGGAAGCTGACCGGCTA
ATAGATAAACTCAAACCCATCAAGGAACTTGAGGATAACCTAAAGAAAAACATCTCTGAGATAAAGGAATTGATAAACCAAGCTCGGAAA
CAAGCCAATTCTATCAAAGTATCTGTGTCTTCAGGAGGTGACTGCATTCGAACATACAAACCAGAAATCAAGAAAGGAAGTTACAATAAT
ATTGTTGTCAACGTAAAGACAGCTGTTGCTGATAACCTCCTCTTTTATCTTGGAAGTGCCAAATTTATTGACTTTCTGGCTATAGAAATG
CGTAAAGGCAAAGTCAGCTTCCTCTGGGATGTTGGATCTGGAGTTGGACGTGTAGAGTACCCAGATTTGACTATTGATGACTCATATTGG
TACCGTATCGTAGCATCAAGAACTGGGAGAAATGGAACTATTTCTGTGAGAGCCCTGGATGGACCCAAAGCCAGCATTGTGCCCAGCACA
CACCATTCGACGTCTCCTCCAGGGTACACGATTCTAGATGTGGATGCAAATGCAATGCTGTTTGTTGGTGGCCTGACTGGGAAATTAAAG
AAGGCTGATGCTGTACGTGTGATTACATTCACTGGCTGCATGGGAGAAACATACTTTGACAACAAACCTATAGGTTTGTGGAATTTCCGA
GAAAAAGAAGGTGACTGCAAAGGATGCACTGTCAGTCCTCAGGTGGAAGATAGTGAGGGGACTATTCAATTTGATGGAGAAGGTTATGCA
TTGGTCAGCCGTCCCATTCGCTGGTACCCCAACATCTCCACTGTCATGTTCAAGTTCAGAACATTTTCTTCGAGTGCTCTTCTGATGTAT
CTTGCCACACGAGACCTGAGAGATTTCATGAGTGTGGAGCTCACTGATGGGCACATAAAAGTCAGTTACGATCTGGGCTCAGGAATGGCT
TCCGTTGTCAGCAATCAAAACCATAATGATGGGAAATGGAAATCATTCACTCTGTCAAGAATTCAAAAACAAGCCAATATATCAATTGTA
GATATAGATACTAATCAGGAGGAGAATATAGCAACTTCGTCTTCTGGAAACAACTTTGGTCTTGACTTGAAAGCAGATGACAAAATATAT
TTTGGTGGCCTGCCAACGCTGAGAAACTTGAGTATGAAAGCAAGGCCAGAAGTAAATCTGAAGAAATATTCCGGCTGCCTCAAAGATATT
GAAATTTCAAGAACTCCGTACAATATACTCAGTAGTCCCGATTATGTTGGTGTTACCAAAGGATGTTCCCTGGAGAATGTTTACACAGTT
AGCTTTCCTAAGCCTGGTTTTGTGGAGCTCTCCCCTGTGCCAATTGATGTAGGAACAGAAATCAACCTGTCATTCAGCACCAAGAATGAG
TCCGGCATCATTCTTTTGGGAAGTGGAGGGACACCAGCACCACCTAGGAGAAAACGAAGGCAGACTGGACAGGCCTATTATGCAATACTC
CTCAACAGGGGCCGTCTGGAAGTGCATCTCTCCACAGGGGCACGAACAATGAGGAAAATTGTGATCAGACCAGAGCCGAATCTGTTTCAT
GATGGAAGAGAACATTCCGTTCATGTAGAGCGAACTAGAGGCATCTTTACAGTTCAAGTGGATGAAAACAGAAGATACATGCAAAACCTG
ACAGTTGAACAGCCTATCGAAGTTAAAAAGCTTTTCGTTGGGGGTGCTCCACCTGAATTTCAACCTTCCCCACTCAGAAATATTCCTCCT
TTTGAAGGCTGCATATGGAATCTTGTTATTAACTCTGTCCCCATGGACTTTGCAAGGCCTGTGTCCTTCAAAAATGCTGACATTGGTCGC
TGTGCCCATCAGAAACTCCGTGAAGATGAAGATGGAGCAGCTCCAGCTGAAATAGTTATCCAGCCTGAGCCAGTTCCCACCCCAGCCTTT
CCTACGCCCACCCCAGTTCTGACACATGGTCCTTGTGCTGCAGAATCAGAACCAGCTCTTTTGATAGGGAGCAAGCAGTTCGGGCTTTCA
AGAAACAGTCACATTGCAATTGCATTTGATGACACCAAAGTTAAAAACCGTCTCACAATTGAGTTGGAAGTAAGAACCGAAGCTGAATCC
GGCTTGCTTTTTTACATGGCTCGCATCAATCATGCTGATTTTGCAACAGTTCAGCTGAGAAATGGATTGCCCTACTTCAGCTATGACTTG
GGGAGTGGGGACACCCACACCATGATCCCCACCAAAATCAATGATGGCCAGTGGCACAAGATTAAGATAATGAGAAGTAAGCAAGAAGGA
ATTCTTTATGTAGATGGGGCTTCCAACAGAACCATCAGTCCCAAAAAAGCCGACATCCTGGATGTCGTGGGAATGCTGTATGTTGGTGGG
TTACCCATCAACTACACTACCCGAAGAATTGGTCCAGTGACCTATAGCATTGATGGCTGCGTCAGGAATCTCCACATGGCAGAGGCCCCT
GCCGATCTGGAACAACCCACCTCCAGCTTCCATGTTGGGACATGTTTTGCAAATGCTCAGAGGGGAACATATTTTGACGGAACCGGTTTT
GCCAAAGCAGTTGGTGGATTCAAAGTGGGATTGGACCTTCTTGTAGAATTTGAATTCCGCACAACTACAACGACTGGAGTTCTTCTGGGG
ATCAGTAGTCAAAAAATGGATGGAATGGGTATTGAAATGATTGATGAAAAGTTGATGTTTCATGTGGACAATGGTGCGGGCAGATTCACT
GCTGTCTATGATGCTGGGGTTCCAGGGCATTTGTGTGATGGACAATGGCATAAAGTCACTGCCAACAAGATCAAACACCGCATTGAGCTC
ACAGTCGATGGGAACCAGGTGGAAGCCCAAAGCCCAAACCCAGCATCTACATCAGCTGACACAAATGACCCTGTGTTTGTTGGAGGCTTC
CCAGATGACCTCAAGCAGTTTGGCCTAACAACCAGTATTCCGTTCCGAGGTTGCATCAGATCCCTGAAGCTCACCAAAGGCACAGGCAAG
CCACTGGAGGTTAATTTTGCCAAGGCCCTGGAACTGAGGGGCGTTCAACCTGTATCATGCCCAGCCAACTAATAAAAATAAGTGTAACCC
CAGGAAGAGTCTGTCAAAACAAGTATATCAAGTAAAACAAACAAATATATTTTACCTATATATGTTAATTAAACTAATTTGTGCATGTAC
ATAGAATTCTTTCTGTATTCAGATGGTGCTAATTCAGACTCCAGACTGAATTTTAATTCAAGTTCTTTCTCAAGTCTATAAATAATATTA

>14699_14699_1_CD83-LAMA2_CD83_chr6_14118296_ENST00000379153_LAMA2_chr6_129663488_ENST00000421865_length(amino acids)=1736AA_BP=51
MSRGLQLLLLSCAYSLAPATPEVKVACSEDVDLPCTAPWDPQVPYTVSWVKNCQHHTAGDFCERCALGYYGIVKGLPNDCQQCACPLISS
SNNFSPSCVAEGLDDYRCTACPRGYEGQYCERCAPGYTGSPGNPGGSCQECECDPYGSLPVPCDPVTGFCTCRPGATGRKCDGCKHWHAR
EGWECVFCGDECTGLLLGDLARLEQMVMSINLTGPLPAPYKMLYGLENMTQELKHLLSPQRAPERLIQLAEGNLNTLVTEMNELLTRATK
VTADGEQTGQDAERTNTRAKSLGEFIKELARDAEAVNEKAIKLNETLGTRDEAFERNLEGLQKEIDQMIKELRRKNLETQKEIAEDELVA
AEALLKKVKKLFGESRGENEEMEKDLREKLADYKNKVDDAWDLLREATDKIREANRLFAVNQKNMTALEKKKEAVESGKRQIENTLKEGN
DILDEANRLADEINSIIDYVEDIQTKLPPMSEELNDKIDDLSQEIKDRKLAEKVSQAESHAAQLNDSSAVLDGILDEAKNISFNATAAFK
AYSNIKDYIDEAEKVAKEAKDLAHEATKLATGPRGLLKEDAKGCLQKSFRILNEAKKLANDVKENEDHLNGLKTRIENADARNGDLLRTL
NDTLGKLSAIPNDTAAKLQAVKDKARQANDTAKDVLAQITELHQNLDGLKKNYNKLADSVAKTNAVVKDPSKNKIIADADATVKNLEQEA
DRLIDKLKPIKELEDNLKKNISEIKELINQARKQANSIKVSVSSGGDCIRTYKPEIKKGSYNNIVVNVKTAVADNLLFYLGSAKFIDFLA
IEMRKGKVSFLWDVGSGVGRVEYPDLTIDDSYWYRIVASRTGRNGTISVRALDGPKASIVPSTHHSTSPPGYTILDVDANAMLFVGGLTG
KLKKADAVRVITFTGCMGETYFDNKPIGLWNFREKEGDCKGCTVSPQVEDSEGTIQFDGEGYALVSRPIRWYPNISTVMFKFRTFSSSAL
LMYLATRDLRDFMSVELTDGHIKVSYDLGSGMASVVSNQNHNDGKWKSFTLSRIQKQANISIVDIDTNQEENIATSSSGNNFGLDLKADD
KIYFGGLPTLRNLSMKARPEVNLKKYSGCLKDIEISRTPYNILSSPDYVGVTKGCSLENVYTVSFPKPGFVELSPVPIDVGTEINLSFST
KNESGIILLGSGGTPAPPRRKRRQTGQAYYAILLNRGRLEVHLSTGARTMRKIVIRPEPNLFHDGREHSVHVERTRGIFTVQVDENRRYM
QNLTVEQPIEVKKLFVGGAPPEFQPSPLRNIPPFEGCIWNLVINSVPMDFARPVSFKNADIGRCAHQKLREDEDGAAPAEIVIQPEPVPT
PAFPTPTPVLTHGPCAAESEPALLIGSKQFGLSRNSHIAIAFDDTKVKNRLTIELEVRTEAESGLLFYMARINHADFATVQLRNGLPYFS
YDLGSGDTHTMIPTKINDGQWHKIKIMRSKQEGILYVDGASNRTISPKKADILDVVGMLYVGGLPINYTTRRIGPVTYSIDGCVRNLHMA
EAPADLEQPTSSFHVGTCFANAQRGTYFDGTGFAKAVGGFKVGLDLLVEFEFRTTTTTGVLLGISSQKMDGMGIEMIDEKLMFHVDNGAG
RFTAVYDAGVPGHLCDGQWHKVTANKIKHRIELTVDGNQVEAQSPNPASTSADTNDPVFVGGFPDDLKQFGLTTSIPFRGCIRSLKLTKG

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Fusion Gene PPI Analysis for CD83-LAMA2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CD83-LAMA2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CD83-LAMA2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCD83C0003873Rheumatoid Arthritis1CTD_human
HgeneCD83C0023893Liver Cirrhosis, Experimental1CTD_human
HgeneCD83C0037274Dermatologic disorders1CTD_human
HgeneCD83C0087031Juvenile-Onset Still Disease1CTD_human
HgeneCD83C0274861Arsenic Poisoning, Inorganic1CTD_human
HgeneCD83C0274862Nervous System, Organic Arsenic Poisoning1CTD_human
HgeneCD83C0311375Arsenic Poisoning1CTD_human
HgeneCD83C0751851Arsenic Encephalopathy1CTD_human
HgeneCD83C0751852Arsenic Induced Polyneuropathy1CTD_human
HgeneCD83C3495559Juvenile arthritis1CTD_human
HgeneCD83C3714758Juvenile psoriatic arthritis1CTD_human
HgeneCD83C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneCD83C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human
TgeneC1263858Muscular dystrophy congenital, merosin negative6CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0026850Muscular Dystrophy2CTD_human
TgeneC0036341Schizophrenia2CTD_human
TgeneC4748327MUSCULAR DYSTROPHY, LIMB-GIRDLE, AUTOSOMAL RECESSIVE 232UNIPROT
TgeneC0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneC0005695Bladder Neoplasm1CTD_human
TgeneC0027092Myopia1CTD_human