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 | Fusion Gene Summary |
| Fusion Gene ORF analysis |
| Fusion Genomic Features |
| Fusion Protein Features |
| Fusion Gene Sequence |
| Fusion Gene PPI analysis |
| Related Drugs |
| Related Diseases |
Fusion gene:MED21-PIP5K1C (FusionGDB2 ID:HG9412TG23396) |
Fusion Gene Summary for MED21-PIP5K1C |
 Fusion gene summary |
| Fusion gene information | Fusion gene name: MED21-PIP5K1C | Fusion gene ID: hg9412tg23396 | Hgene | Tgene | Gene symbol | MED21 | PIP5K1C | Gene ID | 9412 | 23396 |
| Gene name | mediator complex subunit 21 | phosphatidylinositol-4-phosphate 5-kinase type 1 gamma | |
| Synonyms | SRB7|SURB7|hSrb7 | LCCS3|PIP5K-GAMMA|PIP5K1-gamma|PIP5Kgamma | |
| Cytomap | ('MED21')('PIP5K1C') 12p11.23 | 19p13.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | mediator of RNA polymerase II transcription subunit 21RNA polymerase II holoenzyme component SRB7RNAPII complex component SRB7SRB7 suppressor of RNA polymerase B homolog | phosphatidylinositol 4-phosphate 5-kinase type-1 gammadiphosphoinositide kinasephosphatidylinositol-4-phosphate 5-kinase, type I, gammaptdIns(4)P-5-kinase 1 gammatype I PIP kinase | |
| Modification date | 20200313 | 20200313 | |
| UniProtAcc | . | . | |
| Ensembl transtripts involved in fusion gene | ENST00000536503, ENST00000282892, ENST00000546323, | ||
| Fusion gene scores | * DoF score | 5 X 4 X 4=80 | 13 X 12 X 5=780 |
| # samples | 5 | 13 | |
| ** MAII score | log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(13/780*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context | PubMed: MED21 [Title/Abstract] AND PIP5K1C [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint | MED21(27175554)-PIP5K1C(3661999), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | MED21-PIP5K1C seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MED21-PIP5K1C seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | MED21 | GO:0045944 | positive regulation of transcription by RNA polymerase II | 12037571 |
| Fusion gene breakpoints across MED21 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across PIP5K1C (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene information * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SARC | TCGA-DX-A1KZ-01A | MED21 | chr12 | 27175554 | - | PIP5K1C | chr19 | 3661999 | - |
| ChimerDB4 | SARC | TCGA-DX-A1KZ-01A | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - |
| ChimerDB4 | SARC | TCGA-RN-AAAQ-01A | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - |
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Fusion Gene ORF analysis for MED21-PIP5K1C |
| Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| ORF | Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| 3UTR-3CDS | ENST00000536503 | ENST00000335312 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - |
| 3UTR-3CDS | ENST00000536503 | ENST00000537021 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - |
| 3UTR-3CDS | ENST00000536503 | ENST00000539785 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - |
| 3UTR-3CDS | ENST00000536503 | ENST00000589578 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - |
| 3UTR-5UTR | ENST00000536503 | ENST00000587482 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - |
| 5CDS-5UTR | ENST00000282892 | ENST00000587482 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - |
| 5CDS-5UTR | ENST00000546323 | ENST00000587482 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - |
| In-frame | ENST00000282892 | ENST00000335312 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - |
| In-frame | ENST00000282892 | ENST00000537021 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - |
| In-frame | ENST00000282892 | ENST00000539785 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - |
| In-frame | ENST00000282892 | ENST00000589578 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - |
| In-frame | ENST00000546323 | ENST00000335312 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - |
| In-frame | ENST00000546323 | ENST00000537021 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - |
| In-frame | ENST00000546323 | ENST00000539785 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - |
| In-frame | ENST00000546323 | ENST00000589578 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - |
| ORFfinder result based on the fusion transcript sequence of in-frame fusion genes. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000546323 | MED21 | chr12 | 27175554 | + | ENST00000335312 | PIP5K1C | chr19 | 3661999 | - | 4848 | 76 | 7 | 1863 | 618 |
| ENST00000546323 | MED21 | chr12 | 27175554 | + | ENST00000539785 | PIP5K1C | chr19 | 3661999 | - | 2071 | 76 | 7 | 1779 | 590 |
| ENST00000546323 | MED21 | chr12 | 27175554 | + | ENST00000589578 | PIP5K1C | chr19 | 3661999 | - | 2790 | 76 | 7 | 1980 | 657 |
| ENST00000546323 | MED21 | chr12 | 27175554 | + | ENST00000537021 | PIP5K1C | chr19 | 3661999 | - | 3183 | 76 | 7 | 1959 | 650 |
| ENST00000282892 | MED21 | chr12 | 27175554 | + | ENST00000335312 | PIP5K1C | chr19 | 3661999 | - | 4844 | 72 | 3 | 1859 | 618 |
| ENST00000282892 | MED21 | chr12 | 27175554 | + | ENST00000539785 | PIP5K1C | chr19 | 3661999 | - | 2067 | 72 | 3 | 1775 | 590 |
| ENST00000282892 | MED21 | chr12 | 27175554 | + | ENST00000589578 | PIP5K1C | chr19 | 3661999 | - | 2786 | 72 | 3 | 1976 | 657 |
| ENST00000282892 | MED21 | chr12 | 27175554 | + | ENST00000537021 | PIP5K1C | chr19 | 3661999 | - | 3179 | 72 | 3 | 1955 | 650 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000546323 | ENST00000335312 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - | 0.005424471 | 0.9945755 |
| ENST00000546323 | ENST00000539785 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - | 0.011190055 | 0.98881 |
| ENST00000546323 | ENST00000589578 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - | 0.014604041 | 0.98539597 |
| ENST00000546323 | ENST00000537021 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - | 0.012228719 | 0.9877713 |
| ENST00000282892 | ENST00000335312 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - | 0.005421757 | 0.99457824 |
| ENST00000282892 | ENST00000539785 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - | 0.01098742 | 0.9890126 |
| ENST00000282892 | ENST00000589578 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - | 0.014449094 | 0.9855509 |
| ENST00000282892 | ENST00000537021 | MED21 | chr12 | 27175554 | + | PIP5K1C | chr19 | 3661999 | - | 0.012100808 | 0.98789924 |
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Fusion Genomic Features for MED21-PIP5K1C |
| FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints. |
| Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | 1-p | p (fusion gene breakpoint) |
| Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page. |
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Fusion Protein Features for MED21-PIP5K1C |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:27175554/chr19:3661999) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| . | . |
| FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. | FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - In-frame and retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | PIP5K1C | chr12:27175554 | chr19:3661999 | ENST00000335312 | 2 | 18 | 75_443 | 73 | 669.0 | Domain | PIPK | |
| Tgene | PIP5K1C | chr12:27175554 | chr19:3661999 | ENST00000537021 | 2 | 17 | 75_443 | 73 | 701.0 | Domain | PIPK | |
| Tgene | PIP5K1C | chr12:27175554 | chr19:3661999 | ENST00000539785 | 2 | 17 | 75_443 | 73 | 641.0 | Domain | PIPK | |
| Tgene | PIP5K1C | chr12:27175554 | chr19:3661999 | ENST00000589578 | 2 | 17 | 75_443 | 73 | 708.0 | Domain | PIPK |
| - In-frame and not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
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Fusion Gene Sequence for MED21-PIP5K1C |
| For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >52697_52697_1_MED21-PIP5K1C_MED21_chr12_27175554_ENST00000282892_PIP5K1C_chr19_3661999_ENST00000335312_length(transcript)=4844nt_BP=72nt GTTTTGGCGTCTGTTTGCTGCGGTAGGAACATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCACCCTG AAGGGTGCCATCCAGCTGGGCATCGGCTACACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTACGTG GTGGAGAGCATCTTCTTCCCCAGCGAAGGCAGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACCTGTC GCCTTCCGCTACTTCCGGGAGCTCTTTGGGATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTCCAAC CCGGGCGCCAGTGGCTCCCTCTTCTACGTCACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCTGCAG AAGCTGCTCCCTGGCTACTACATGAACCTCAACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTCGGGG GGCAAGAACATCCGCGTCGTGGTCATGAACAACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCACCTAC AAGCGGCGCGCCAGCAAGAAGGAGAAGGAGAAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCTCCTG CTGGACGCCGACACCTTCAGCGCCCTGGTCAAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAGCCTG CTGCTGGGCGTGCACAACATCGACCAGCACGAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGTGGGC CAGAAGGCGCTCTACTCCACGGCCATGGAGTCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGGCGGG ATCCCCGCTGTGAACGGCCGCGGGGAGCGGCTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAAACTG GAGCACACCTGGAAGGCCCTCGTCCACGATGGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTTCATG AGCAACACGGTCTTTCGGAAGAACTCCTCCCTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACCGCTG GGGCCCACCGCTGCCTTCTCGGCCAGCCAGATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCCCACG CTGGAGGACGAAGGCCGGCCCGACCTCCTGCCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCTGTCA TCCACATCCCTCTCCATTCCTGAGCGGTCCCCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACAGGAT GGCAGGCCGCAGGAGGAGCCACCCGCGGAAGAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGTGGTC CCCAAAGAGGAGGACGCAGGGGTGGAGGCTTCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGACGAG GAGGGCGCACCTGCCAGCCAGGCCTCGGACGAGGAGGACGCGCCCGCCACCGACATCTACTTTCCCACCGATGAGAGGAGCTGGGTGTAC TCCCCGCTCCACTATAGCGCCCAGGCCCCCCCGGCCTCCGACGGCGAGAGCGACACATAATTTCTATGCAGCCCCCGACCCAGAGCCGAG CTCCACTTCTGCTCCGGCTGCCCCCGAAGGCGCTGCCCACCCCGCTGAGGCCCAGAGCTCGGGAGATGCCCGCCTCGCCGCCCCACCGGA CCTCGTCCTCCCCCTGCACGGATGCCGACGGCCGGGCCCCTCCCCGACAAGCCTCCCAGGGCCCCGGCACCCCGGTCGGCAGCCTGCCCC TGTGAGACCCACCCTCCCGAGCGGCCAATCGCATTTGAGTCCTTATTTGGCACAGAGACGGAAGCACGTGTGTGCCGTTTTAGGAAAAGA ACAAAAAAGACACAAACAAACCAACCAGAGGGAGAAGAGCCCCTGCCCACTGCACTCTTTGGTTCTCTGCTGTGCCTGCCTGTGTCCTGA GGAAGAAGCCAGGCTGTTCGCGGTGGCCTCTGGGGACCTGAGCCCCGGGGGCCCCATCGGCCTGCAGAGGGGACGGCTGGGGTCCCGAGC AACTCTGCCTCCATCCACGTGGGAAGCGGACCCTCCTGCCCTCAGCTTGGGTTTGGGGGCCTCAGTGCAGGACATCTGGCCTGAACATCG ACTGTGGGGACAGCCCTCGCCCTGCCAAGCACTGCGGCCACTCAGCAGCTATGTTCCCGCCGCAGTGGGGCCCTGACGCCCACCTCCCAG GTGCCCCTCGAGCAAAAACCTCTGGCGCCTCCAATCCAGACCCACCACAGCTGGAGGGCCAGGCCTCCTCTTCCCCAGGCTGCCACCCAC GCTGGCGGAGCTCAGGGCTGGGGACTTGTCCTTCTCTTCCAACGTAGGCCACTCAGCAACTGGCATGGAGGGCCCAGGCAACGGAGACGT TTTCTCCATGGCAGGACAGAGCGGGAGGCCGGGCCTTGGGCCACAGGAGACCAGCTCAGGGCGGAAGGTCAGGCTCCCCGCCCCCTCCAC GTGGAGACATGGCCTAGGGGGCCAGGCCCGGCTCCACAGGAGTCTCCTTCAGGACTGGTGTGGATGTCCGCCGCCTCTTTCTTGTTTAAG TGATGTGATGTCTCCGAGGAGGGGAGAGAAGACTTTGTTTCCGACTCATCACCCTCCAAGAGGGCAGCGCTCCCAGTGGTGGGACTCAGC CCAGACTGCCCTGGGGCAGCTTCCTGGGCCCGCTGCGCTCAGAGGGTGCTGGTTGGAGGCCAGAGCTCGGCAGAGTCACCCACCCTGCCC TTCCCCAGGACCCCTGAGAGGGGCTTATTGGTGATGGCTGTGGGAATCCCCCACTTCCAAGATGTGCCCAGGATGTGAGGAGCTGGAGTG GAAGCTGCACCTTTGGGAAGAATTCCTCTCCAGACCTGGCAGAGCCTGGTGTGGGGTCTGAGACGGCCGGAGAACCTCCCAGGCAGGGCT CTGTGTTTTGTCTGTTACAACCTCCGTATGACGCCACGCCACCCGCTGTTCACGTCCCGTCGGCCTCCTGCACAGCCCACACGCTGCGCC CGGAAGGCCCCTGCTGTGGAGAAGCCGGACCCATCCCCGAGGTCCCCAGCGAGGACACACACTCCACGAGAGCAGCCCCTCCACTCTGCC CAGGAGAGGGGCCGACCCTCCTCGGGAACCGGCCAGCCGCGTGGCTCCCAGCATCCATCAGGACAAGCCCACGTGGGGTCCTCCCTGCGT GCTCAGAGGGTCTGTCCAGCCCTGGGAAGCGACCTTGGCCTCAGTTCACAGCCTGGTGCTCATCTGCTGGCACCGGGCATCCACCCATCA GCCCCCGCCCTGTCCCTCCGAAGGACACCCAGCAGGCACCCCCCGGGGAGGCAGGGGCAGAGGTCAGAAGGGGTGTCTGGGACCTGGATG GCCAGCAGGGACAGGGGCATTGTCATCTCAAAGGCCCAACCCCCAGAGGCCACACCAGTCCTCCCAGGGAGTCCTCGAGTCGCCCTGCCC AGAGCCCTGGCACCAGAGACGCCAAGAGCCTGTGGGGTGACTCGGAGCAGCAGGTGTGGCCCCGGGCGGGCGGCACCGCGTCCAGGGCAG CCTCCCTCCGCTGAGTGACACGGGACACCAGTGCCCGGCCGACGCGCCTTTGCAGGAGAAATGTGCAAACCTCTGTGGATACCATTTCAT TTCCATTCTTGTGTTGTCTCCAAGGCCCTTTTGGAGATATACTTGGTGTTGGTTGTGTTTTTTGGTTCCTTTTCAGAGAACTGTAAACCG AGGCTGACGTGCTCCACTGACTGTGCCGAGGGGCGGGGGCAGGAGGACGGCAAGACCTATTTATAATATTTAGCGAACTCGGTCTCCCTC AGATCCCCCGCGAGGGAGGCTGCTGGACCCACCCCGCTGTCCCCCATGATAGAAGTCTGTAAATACCTTGGTGACCAATGCCCACTTCCC CTCCTGGGTCACCTCTGATGGCTGCTGTCCACTGAGAACGTGGGCAGTGTCCAAATTCCTGTACTGTAAAGACTAAAAGGCGTTTGCTCT GAGACTGACAAGGCGGAAACTTCCATGTGTCTCCTGCCAGGCTCTGTCCCCCTACGCCATCCCGACACGTCCCCGTTCCCCCGAAACCTG GCTCAGTGCAATACTCCCATTGCCATGGGGTCCTTCACCATGGTACTGTCTCCACAGCCCTCAGTCCCCACCCCAGGAGAGGCGCCTGCC ACCTCCTCCTCATCTCCGGTGGTTCAATCGCTCCGCCTGTCCCCAACCCAGTCCCATTTTTATGGCCAAACTGATTCTGAAACAAAATGA AACTGCAAACCTCGTGTGTCTTAACTCCCCCCAGGGATGCCACTCCATTCCTCCGCCCCGTGGTCTGGTGCGTGACAATCCAAAGCGCCG AGACGAGGGTGCTGTGTCCCTCAAACCCAGAGTGGTGGGCGCCTCTGAAACCATACAGCCACTCCTGGCCCCAAACACTGGTTTGCATCC CAGGTTCCTCGCCCACCTACCCCCGCCACACCCCGTCTTTTTAGAGATCTCTCTAATAAATCGGGTAATAAGCA >52697_52697_1_MED21-PIP5K1C_MED21_chr12_27175554_ENST00000282892_PIP5K1C_chr19_3661999_ENST00000335312_length(amino acids)=618AA_BP=23 MASVCCGRNMADRLTQLQDAVNSTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVA FRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGG KNIRVVVMNNILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLL LGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLE HTWKALVHDGDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTL EDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVP KEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDEEDAPATDIYFPTDERSWVYSPLHYSAQAPPASDGESDT -------------------------------------------------------------- >52697_52697_2_MED21-PIP5K1C_MED21_chr12_27175554_ENST00000282892_PIP5K1C_chr19_3661999_ENST00000537021_length(transcript)=3179nt_BP=72nt GTTTTGGCGTCTGTTTGCTGCGGTAGGAACATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCACCCTG AAGGGTGCCATCCAGCTGGGCATCGGCTACACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTACGTG GTGGAGAGCATCTTCTTCCCCAGCGAAGGCAGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACCTGTC GCCTTCCGCTACTTCCGGGAGCTCTTTGGGATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTCCAAC CCGGGCGCCAGTGGCTCCCTCTTCTACGTCACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCTGCAG AAGCTGCTCCCTGGCTACTACATGAACCTCAACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTCGGGG GGCAAGAACATCCGCGTCGTGGTCATGAACAACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCACCTAC AAGCGGCGCGCCAGCAAGAAGGAGAAGGAGAAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCTCCTG CTGGACGCCGACACCTTCAGCGCCCTGGTCAAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAGCCTG CTGCTGGGCGTGCACAACATCGACCAGCACGAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGTGGGC CAGAAGGCGCTCTACTCCACGGCCATGGAGTCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGGCGGG ATCCCCGCTGTGAACGGCCGCGGGGAGCGGCTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAAACTG GAGCACACCTGGAAGGCCCTCGTCCACGATGGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTTCATG AGCAACACGGTCTTTCGGAAGAACTCCTCCCTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACCGCTG GGGCCCACCGCTGCCTTCTCGGCCAGCCAGATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCCCACG CTGGAGGACGAAGGCCGGCCCGACCTCCTGCCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCTGTCA TCCACATCCCTCTCCATTCCTGAGCGGTCCCCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACAGGAT GGCAGGCCGCAGGAGGAGCCACCCGCGGAAGAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGTGGTC CCCAAAGAGGAGGACGCAGGGGTGGAGGCTTCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGACGAG GAGGGCGCACCTGCCAGCCAGGCCTCGGACGAGGAGGACGCGCCCGCCACCGACATCTACTTTTGGCGCCTCTGGGGTCCCCATGCACCC ACCTGGCCCTGGAGAAGGGAGGGACGGGCCGCGTGCCTGTGCCCCTACCCACCGCACGTCGTCACCCCTTTTCCTGGGACTGGTTTGTGC GCGTCCTGGTCTCCGGATGGTACGGGGGGCCTGGGGGCCATGTCGTGCTGTGTGTCTGTGTCCTGATGCCCTGCCAGGTGGGCAGCAGAG AAGGGAGAAGGGTCCTCGGTCCTGCCCCTGCCCCGGCACCCCCCACCTTCTGCTTGGCAGTCAGCTGTCCCCACCTGCTCCCCGCCACCT CCCTCCGCCTCTCCCACCCGACCACGGGGGTGGCCGCCTCATCCGCTGTCCTCTGTTTTCCTTCCTCCTCCGGCCCACCCGGCCCGCCCC GTCCAGTTCACGGATGGGAGGTACTGGATTTACTCTCCCCGCCATCGCCGACTGCGGGCCGTGACGCTGAGCGCCTCGGGGACTGTAAGT GACCGCAGCCGGCCACCCTGGGGAGAAGGGGCAGTGCCCCTCGGGCAGCAGGGAGCCGCAGGTCCCCGGCCGGAAGCTCAGTGTCTGACG TCAGTTGTTTTCCAGAAGGGCTTTGGGTAAATCACGGCTGCAATTGAGGTCAGCCACGCTGGCCCCGGACCAGGCGCTGGGCTGCATGCG TCACTGGGAATGTCATTCGGTCCCACGTCGAACCGGGCGCTCCATAGGGCAGCACCATCACCAGGTGCACAGCTGAGGCCCAGGGTCTGC TTCGGACCCCGGCCAGACCCCAGCGAGCCCCTCTCTGCCCCTGGACCCAGCCCTCTCGTGTCAGGGTGTCTTGGGTGGACGCTTCTCACT CGTGCAGACCTGGCTGCCCGTGGCCCCGCTGGCTGCACAGGGGAGGTTGCACAGGTCAGCAGAGTGGCTGCAGGGCCGGGCTCTGAACCG CAGGGCCATGGAGACGGGGAGGAGATGGTCTCTCCACACCCACCTCACAGATGGAGGCGCTGAGGCCTCGGCTCCCCTGGGAGCCTGGGA GACCACACGGTTTAGTCAAAATCCAGATCCCCAAGCTCTCAAGGAGGTCCCCCTGGGACGCCACATGGGCCCCACGTAGCTGTGAGATCC TCAGGGCCTGCTGTTGTCATTATGACCAATAAGCAAGGGGCCCAGAGAGCCTAAGAGACCTGCCCAGCACCGCACAGCCAGAACGGGGCG CAGACCCAAAGCAGGAGTGTCCCCTCGAGACAAAGCCTCCGCCGAGGCCGCCGTGACTCCCCGCCCATCAGCAAACCTCTCCGAGCACCT CTGTGTGCCAGGCACTGTGGAGTGACCCCAAGAGGTGGAGACCACTTCCCCGGCTGCTCTAGGCAGCTCCGTCCCACGGAGCCAGCGGGA AGCCAGCCACCGCGAAGCCGTGCCCCGGA >52697_52697_2_MED21-PIP5K1C_MED21_chr12_27175554_ENST00000282892_PIP5K1C_chr19_3661999_ENST00000537021_length(amino acids)=650AA_BP=23 MASVCCGRNMADRLTQLQDAVNSTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVA FRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGG KNIRVVVMNNILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLL LGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLE HTWKALVHDGDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTL EDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVP KEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDEEDAPATDIYFWRLWGPHAPTWPWRREGRAACLCPYPPHVVTPFPGTGLCA SWSPDGTGGLGAMSCCVSVS -------------------------------------------------------------- >52697_52697_3_MED21-PIP5K1C_MED21_chr12_27175554_ENST00000282892_PIP5K1C_chr19_3661999_ENST00000539785_length(transcript)=2067nt_BP=72nt GTTTTGGCGTCTGTTTGCTGCGGTAGGAACATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCACCCTG AAGGGTGCCATCCAGCTGGGCATCGGCTACACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTACGTG GTGGAGAGCATCTTCTTCCCCAGCGAAGGCAGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACCTGTC GCCTTCCGCTACTTCCGGGAGCTCTTTGGGATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTCCAAC CCGGGCGCCAGTGGCTCCCTCTTCTACGTCACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCTGCAG AAGCTGCTCCCTGGCTACTACATGAACCTCAACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTCGGGG GGCAAGAACATCCGCGTCGTGGTCATGAACAACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCACCTAC AAGCGGCGCGCCAGCAAGAAGGAGAAGGAGAAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCTCCTG CTGGACGCCGACACCTTCAGCGCCCTGGTCAAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAGCCTG CTGCTGGGCGTGCACAACATCGACCAGCACGAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGTGGGC CAGAAGGCGCTCTACTCCACGGCCATGGAGTCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGGCGGG ATCCCCGCTGTGAACGGCCGCGGGGAGCGGCTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAAACTG GAGCACACCTGGAAGGCCCTCGTCCACGATGGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTTCATG AGCAACACGGTCTTTCGGAAGAACTCCTCCCTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACCGCTG GGGCCCACCGCTGCCTTCTCGGCCAGCCAGATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCCCACG CTGGAGGACGAAGGCCGGCCCGACCTCCTGCCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCTGTCA TCCACATCCCTCTCCATTCCTGAGCGGTCCCCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACAGGAT GGCAGGCCGCAGGAGGAGCCACCCGCGGAAGAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGTGGTC CCCAAAGAGGAGGACGCAGGGGTGGAGGCTTCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGACGAG GAGGGCGCACCTGCCAGCCAGGCCTCGGACGAGGAGGACGCGCCCGCCACCGACATCTACTTTTAATTTCTATGCAGCCCCCGACCCAGA GCCGAGCTCCACTTCTGCTCCGGCTGCCCCCGAAGGCGCTGCCCACCCCGCTGAGGCCCAGAGCTCGGGAGATGCCCGCCTCGCCGCCCC ACCGGACCTCGTCCTCCCCCTGCACGGATGCCGACGGCCGGGCCCCTCCCCGACAAGCCTCCCAGGGCCCCGGCACCCCGGTCGGCAGCC TGCCCCTGTGAGACCCACCCTCCCGAGCGGCCAATCGCATTTGAGTCCTTATTTGGCACAGAGACGGAAGCACGTGTGTGCCGTTTT >52697_52697_3_MED21-PIP5K1C_MED21_chr12_27175554_ENST00000282892_PIP5K1C_chr19_3661999_ENST00000539785_length(amino acids)=590AA_BP=23 MASVCCGRNMADRLTQLQDAVNSTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVA FRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGG KNIRVVVMNNILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLL LGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLE HTWKALVHDGDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTL EDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVP KEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDEEDAPATDIYF -------------------------------------------------------------- >52697_52697_4_MED21-PIP5K1C_MED21_chr12_27175554_ENST00000282892_PIP5K1C_chr19_3661999_ENST00000589578_length(transcript)=2786nt_BP=72nt GTTTTGGCGTCTGTTTGCTGCGGTAGGAACATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCACCCTG AAGGGTGCCATCCAGCTGGGCATCGGCTACACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTACGTG GTGGAGAGCATCTTCTTCCCCAGCGAAGGCAGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACCTGTC GCCTTCCGCTACTTCCGGGAGCTCTTTGGGATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTCCAAC CCGGGCGCCAGTGGCTCCCTCTTCTACGTCACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCTGCAG AAGCTGCTCCCTGGCTACTACATGAACCTCAACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTCGGGG GGCAAGAACATCCGCGTCGTGGTCATGAACAACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCACCTAC AAGCGGCGCGCCAGCAAGAAGGAGAAGGAGAAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCTCCTG CTGGACGCCGACACCTTCAGCGCCCTGGTCAAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAGCCTG CTGCTGGGCGTGCACAACATCGACCAGCACGAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGTGGGC CAGAAGGCGCTCTACTCCACGGCCATGGAGTCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGGCGGG ATCCCCGCTGTGAACGGCCGCGGGGAGCGGCTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAAACTG GAGCACACCTGGAAGGCCCTCGTCCACGATGGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTTCATG AGCAACACGGTCTTTCGGAAGAACTCCTCCCTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACCGCTG GGGCCCACCGCTGCCTTCTCGGCCAGCCAGATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCCCACG CTGGAGGACGAAGGCCGGCCCGACCTCCTGCCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCTGTCA TCCACATCCCTCTCCATTCCTGAGCGGTCCCCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACAGGAT GGCAGGCCGCAGGAGGAGCCACCCGCGGAAGAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGTGGTC CCCAAAGAGGAGGACGCAGGGGTGGAGGCTTCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGACGAG GAGGGCGCACCTGCCAGCCAGGCCTCGGACGAGGAGGACGCGCCCGCCACCGACATCTACTTTTTCACGGATGGGAGGTACTGGATTTAC TCTCCCCGCCATCGCCGACTGCGGGCCGTGACGCTGAGCGCCTCGGGGACTGTAAGTGACCGCAGCCGGCCACCCTGGGGAGAAGGGGCA GTGCCCCTCGGGCAGCAGGGAGCCGCAGGTCCCCGGCCGGAAGCTCAGTGTCTGACGTCAGTTGTTTTCCAGAAGGGCTTTGGGTAAATC ACGGCTGCAATTGAGGTCAGCCACGCTGGCCCCGGACCAGGCGCTGGGCTGCATGCGTCACTGGGAATGTCATTCGGTCCCACGTCGAAC CGGGCGCTCCATAGGGCAGCACCATCACCAGGTGCACAGCTGAGGCCCAGGGTCTGCTTCGGACCCCGGCCAGACCCCAGCGAGCCCCTC TCTGCCCCTGGACCCAGCCCTCTCGTGTCAGGGTGTCTTGGGTGGACGCTTCTCACTCGTGCAGACCTGGCTGCCCGTGGCCCCGCTGGC TGCACAGGGGAGGTTGCACAGGTCAGCAGAGTGGCTGCAGGGCCGGGCTCTGAACCGCAGGGCCATGGAGACGGGGAGGAGATGGTCTCT CCACACCCACCTCACAGATGGAGGCGCTGAGGCCTCGGCTCCCCTGGGAGCCTGGGAGACCACACGGTTTAGTCAAAATCCAGATCCCCA AGCTCTCAAGGAGGTCCCCCTGGGACGCCACATGGGCCCCACGTAGCTGTGAGATCCTCAGGGCCTGCTGTTGTCATTATGACCAATAAG CAAGGGGCCCAGAGAGCCTAAGAGACCTGCCCAGCACCGCACAGCCAGAACGGGGCGCAGACCCAAAGCAGGAGTGTCCCCTCGAGACAA AGCCTCCGCCGAGGCCGCCGTGACTCCCCGCCCATCAGCAAACCTCTCCGAGCACCTCTGTGTGCCAGGCACTGTGGAGTGACCCCAAGA GGTGGAGACCACTTCCCCGGCTGCTCTAGGCAGCTCCGTCCCACGGAGCCAGCGGGAAGCCAGCCACCGCGAAGCCGTGCCCCGGA >52697_52697_4_MED21-PIP5K1C_MED21_chr12_27175554_ENST00000282892_PIP5K1C_chr19_3661999_ENST00000589578_length(amino acids)=657AA_BP=23 MASVCCGRNMADRLTQLQDAVNSTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVA FRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGG KNIRVVVMNNILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLL LGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLE HTWKALVHDGDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTL EDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVP KEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDEEDAPATDIYFFTDGRYWIYSPRHRRLRAVTLSASGTVSDRSRPPWGEGAV PLGQQGAAGPRPEAQCLTSVVFQKGFG -------------------------------------------------------------- >52697_52697_5_MED21-PIP5K1C_MED21_chr12_27175554_ENST00000546323_PIP5K1C_chr19_3661999_ENST00000335312_length(transcript)=4848nt_BP=76nt AGCTGTTTTGGCGTCTGTTTGCTGCGGTAGGAACATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCAC CCTGAAGGGTGCCATCCAGCTGGGCATCGGCTACACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTA CGTGGTGGAGAGCATCTTCTTCCCCAGCGAAGGCAGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACC TGTCGCCTTCCGCTACTTCCGGGAGCTCTTTGGGATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTC CAACCCGGGCGCCAGTGGCTCCCTCTTCTACGTCACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCT GCAGAAGCTGCTCCCTGGCTACTACATGAACCTCAACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTC GGGGGGCAAGAACATCCGCGTCGTGGTCATGAACAACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCAC CTACAAGCGGCGCGCCAGCAAGAAGGAGAAGGAGAAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCT CCTGCTGGACGCCGACACCTTCAGCGCCCTGGTCAAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAG CCTGCTGCTGGGCGTGCACAACATCGACCAGCACGAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGT GGGCCAGAAGGCGCTCTACTCCACGGCCATGGAGTCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGG CGGGATCCCCGCTGTGAACGGCCGCGGGGAGCGGCTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAA ACTGGAGCACACCTGGAAGGCCCTCGTCCACGATGGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTT CATGAGCAACACGGTCTTTCGGAAGAACTCCTCCCTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACC GCTGGGGCCCACCGCTGCCTTCTCGGCCAGCCAGATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCC CACGCTGGAGGACGAAGGCCGGCCCGACCTCCTGCCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCT GTCATCCACATCCCTCTCCATTCCTGAGCGGTCCCCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACA GGATGGCAGGCCGCAGGAGGAGCCACCCGCGGAAGAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGT GGTCCCCAAAGAGGAGGACGCAGGGGTGGAGGCTTCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGA CGAGGAGGGCGCACCTGCCAGCCAGGCCTCGGACGAGGAGGACGCGCCCGCCACCGACATCTACTTTCCCACCGATGAGAGGAGCTGGGT GTACTCCCCGCTCCACTATAGCGCCCAGGCCCCCCCGGCCTCCGACGGCGAGAGCGACACATAATTTCTATGCAGCCCCCGACCCAGAGC CGAGCTCCACTTCTGCTCCGGCTGCCCCCGAAGGCGCTGCCCACCCCGCTGAGGCCCAGAGCTCGGGAGATGCCCGCCTCGCCGCCCCAC CGGACCTCGTCCTCCCCCTGCACGGATGCCGACGGCCGGGCCCCTCCCCGACAAGCCTCCCAGGGCCCCGGCACCCCGGTCGGCAGCCTG CCCCTGTGAGACCCACCCTCCCGAGCGGCCAATCGCATTTGAGTCCTTATTTGGCACAGAGACGGAAGCACGTGTGTGCCGTTTTAGGAA AAGAACAAAAAAGACACAAACAAACCAACCAGAGGGAGAAGAGCCCCTGCCCACTGCACTCTTTGGTTCTCTGCTGTGCCTGCCTGTGTC CTGAGGAAGAAGCCAGGCTGTTCGCGGTGGCCTCTGGGGACCTGAGCCCCGGGGGCCCCATCGGCCTGCAGAGGGGACGGCTGGGGTCCC GAGCAACTCTGCCTCCATCCACGTGGGAAGCGGACCCTCCTGCCCTCAGCTTGGGTTTGGGGGCCTCAGTGCAGGACATCTGGCCTGAAC ATCGACTGTGGGGACAGCCCTCGCCCTGCCAAGCACTGCGGCCACTCAGCAGCTATGTTCCCGCCGCAGTGGGGCCCTGACGCCCACCTC CCAGGTGCCCCTCGAGCAAAAACCTCTGGCGCCTCCAATCCAGACCCACCACAGCTGGAGGGCCAGGCCTCCTCTTCCCCAGGCTGCCAC CCACGCTGGCGGAGCTCAGGGCTGGGGACTTGTCCTTCTCTTCCAACGTAGGCCACTCAGCAACTGGCATGGAGGGCCCAGGCAACGGAG ACGTTTTCTCCATGGCAGGACAGAGCGGGAGGCCGGGCCTTGGGCCACAGGAGACCAGCTCAGGGCGGAAGGTCAGGCTCCCCGCCCCCT CCACGTGGAGACATGGCCTAGGGGGCCAGGCCCGGCTCCACAGGAGTCTCCTTCAGGACTGGTGTGGATGTCCGCCGCCTCTTTCTTGTT TAAGTGATGTGATGTCTCCGAGGAGGGGAGAGAAGACTTTGTTTCCGACTCATCACCCTCCAAGAGGGCAGCGCTCCCAGTGGTGGGACT CAGCCCAGACTGCCCTGGGGCAGCTTCCTGGGCCCGCTGCGCTCAGAGGGTGCTGGTTGGAGGCCAGAGCTCGGCAGAGTCACCCACCCT GCCCTTCCCCAGGACCCCTGAGAGGGGCTTATTGGTGATGGCTGTGGGAATCCCCCACTTCCAAGATGTGCCCAGGATGTGAGGAGCTGG AGTGGAAGCTGCACCTTTGGGAAGAATTCCTCTCCAGACCTGGCAGAGCCTGGTGTGGGGTCTGAGACGGCCGGAGAACCTCCCAGGCAG GGCTCTGTGTTTTGTCTGTTACAACCTCCGTATGACGCCACGCCACCCGCTGTTCACGTCCCGTCGGCCTCCTGCACAGCCCACACGCTG CGCCCGGAAGGCCCCTGCTGTGGAGAAGCCGGACCCATCCCCGAGGTCCCCAGCGAGGACACACACTCCACGAGAGCAGCCCCTCCACTC TGCCCAGGAGAGGGGCCGACCCTCCTCGGGAACCGGCCAGCCGCGTGGCTCCCAGCATCCATCAGGACAAGCCCACGTGGGGTCCTCCCT GCGTGCTCAGAGGGTCTGTCCAGCCCTGGGAAGCGACCTTGGCCTCAGTTCACAGCCTGGTGCTCATCTGCTGGCACCGGGCATCCACCC ATCAGCCCCCGCCCTGTCCCTCCGAAGGACACCCAGCAGGCACCCCCCGGGGAGGCAGGGGCAGAGGTCAGAAGGGGTGTCTGGGACCTG GATGGCCAGCAGGGACAGGGGCATTGTCATCTCAAAGGCCCAACCCCCAGAGGCCACACCAGTCCTCCCAGGGAGTCCTCGAGTCGCCCT GCCCAGAGCCCTGGCACCAGAGACGCCAAGAGCCTGTGGGGTGACTCGGAGCAGCAGGTGTGGCCCCGGGCGGGCGGCACCGCGTCCAGG GCAGCCTCCCTCCGCTGAGTGACACGGGACACCAGTGCCCGGCCGACGCGCCTTTGCAGGAGAAATGTGCAAACCTCTGTGGATACCATT TCATTTCCATTCTTGTGTTGTCTCCAAGGCCCTTTTGGAGATATACTTGGTGTTGGTTGTGTTTTTTGGTTCCTTTTCAGAGAACTGTAA ACCGAGGCTGACGTGCTCCACTGACTGTGCCGAGGGGCGGGGGCAGGAGGACGGCAAGACCTATTTATAATATTTAGCGAACTCGGTCTC CCTCAGATCCCCCGCGAGGGAGGCTGCTGGACCCACCCCGCTGTCCCCCATGATAGAAGTCTGTAAATACCTTGGTGACCAATGCCCACT TCCCCTCCTGGGTCACCTCTGATGGCTGCTGTCCACTGAGAACGTGGGCAGTGTCCAAATTCCTGTACTGTAAAGACTAAAAGGCGTTTG CTCTGAGACTGACAAGGCGGAAACTTCCATGTGTCTCCTGCCAGGCTCTGTCCCCCTACGCCATCCCGACACGTCCCCGTTCCCCCGAAA CCTGGCTCAGTGCAATACTCCCATTGCCATGGGGTCCTTCACCATGGTACTGTCTCCACAGCCCTCAGTCCCCACCCCAGGAGAGGCGCC TGCCACCTCCTCCTCATCTCCGGTGGTTCAATCGCTCCGCCTGTCCCCAACCCAGTCCCATTTTTATGGCCAAACTGATTCTGAAACAAA ATGAAACTGCAAACCTCGTGTGTCTTAACTCCCCCCAGGGATGCCACTCCATTCCTCCGCCCCGTGGTCTGGTGCGTGACAATCCAAAGC GCCGAGACGAGGGTGCTGTGTCCCTCAAACCCAGAGTGGTGGGCGCCTCTGAAACCATACAGCCACTCCTGGCCCCAAACACTGGTTTGC ATCCCAGGTTCCTCGCCCACCTACCCCCGCCACACCCCGTCTTTTTAGAGATCTCTCTAATAAATCGGGTAATAAGCA >52697_52697_5_MED21-PIP5K1C_MED21_chr12_27175554_ENST00000546323_PIP5K1C_chr19_3661999_ENST00000335312_length(amino acids)=618AA_BP=23 MASVCCGRNMADRLTQLQDAVNSTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVA FRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGG KNIRVVVMNNILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLL LGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLE HTWKALVHDGDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTL EDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVP KEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDEEDAPATDIYFPTDERSWVYSPLHYSAQAPPASDGESDT -------------------------------------------------------------- >52697_52697_6_MED21-PIP5K1C_MED21_chr12_27175554_ENST00000546323_PIP5K1C_chr19_3661999_ENST00000537021_length(transcript)=3183nt_BP=76nt AGCTGTTTTGGCGTCTGTTTGCTGCGGTAGGAACATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCAC CCTGAAGGGTGCCATCCAGCTGGGCATCGGCTACACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTA CGTGGTGGAGAGCATCTTCTTCCCCAGCGAAGGCAGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACC TGTCGCCTTCCGCTACTTCCGGGAGCTCTTTGGGATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTC CAACCCGGGCGCCAGTGGCTCCCTCTTCTACGTCACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCT GCAGAAGCTGCTCCCTGGCTACTACATGAACCTCAACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTC GGGGGGCAAGAACATCCGCGTCGTGGTCATGAACAACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCAC CTACAAGCGGCGCGCCAGCAAGAAGGAGAAGGAGAAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCT CCTGCTGGACGCCGACACCTTCAGCGCCCTGGTCAAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAG CCTGCTGCTGGGCGTGCACAACATCGACCAGCACGAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGT GGGCCAGAAGGCGCTCTACTCCACGGCCATGGAGTCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGG CGGGATCCCCGCTGTGAACGGCCGCGGGGAGCGGCTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAA ACTGGAGCACACCTGGAAGGCCCTCGTCCACGATGGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTT CATGAGCAACACGGTCTTTCGGAAGAACTCCTCCCTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACC GCTGGGGCCCACCGCTGCCTTCTCGGCCAGCCAGATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCC CACGCTGGAGGACGAAGGCCGGCCCGACCTCCTGCCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCT GTCATCCACATCCCTCTCCATTCCTGAGCGGTCCCCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACA GGATGGCAGGCCGCAGGAGGAGCCACCCGCGGAAGAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGT GGTCCCCAAAGAGGAGGACGCAGGGGTGGAGGCTTCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGA CGAGGAGGGCGCACCTGCCAGCCAGGCCTCGGACGAGGAGGACGCGCCCGCCACCGACATCTACTTTTGGCGCCTCTGGGGTCCCCATGC ACCCACCTGGCCCTGGAGAAGGGAGGGACGGGCCGCGTGCCTGTGCCCCTACCCACCGCACGTCGTCACCCCTTTTCCTGGGACTGGTTT GTGCGCGTCCTGGTCTCCGGATGGTACGGGGGGCCTGGGGGCCATGTCGTGCTGTGTGTCTGTGTCCTGATGCCCTGCCAGGTGGGCAGC AGAGAAGGGAGAAGGGTCCTCGGTCCTGCCCCTGCCCCGGCACCCCCCACCTTCTGCTTGGCAGTCAGCTGTCCCCACCTGCTCCCCGCC ACCTCCCTCCGCCTCTCCCACCCGACCACGGGGGTGGCCGCCTCATCCGCTGTCCTCTGTTTTCCTTCCTCCTCCGGCCCACCCGGCCCG CCCCGTCCAGTTCACGGATGGGAGGTACTGGATTTACTCTCCCCGCCATCGCCGACTGCGGGCCGTGACGCTGAGCGCCTCGGGGACTGT AAGTGACCGCAGCCGGCCACCCTGGGGAGAAGGGGCAGTGCCCCTCGGGCAGCAGGGAGCCGCAGGTCCCCGGCCGGAAGCTCAGTGTCT GACGTCAGTTGTTTTCCAGAAGGGCTTTGGGTAAATCACGGCTGCAATTGAGGTCAGCCACGCTGGCCCCGGACCAGGCGCTGGGCTGCA TGCGTCACTGGGAATGTCATTCGGTCCCACGTCGAACCGGGCGCTCCATAGGGCAGCACCATCACCAGGTGCACAGCTGAGGCCCAGGGT CTGCTTCGGACCCCGGCCAGACCCCAGCGAGCCCCTCTCTGCCCCTGGACCCAGCCCTCTCGTGTCAGGGTGTCTTGGGTGGACGCTTCT CACTCGTGCAGACCTGGCTGCCCGTGGCCCCGCTGGCTGCACAGGGGAGGTTGCACAGGTCAGCAGAGTGGCTGCAGGGCCGGGCTCTGA ACCGCAGGGCCATGGAGACGGGGAGGAGATGGTCTCTCCACACCCACCTCACAGATGGAGGCGCTGAGGCCTCGGCTCCCCTGGGAGCCT GGGAGACCACACGGTTTAGTCAAAATCCAGATCCCCAAGCTCTCAAGGAGGTCCCCCTGGGACGCCACATGGGCCCCACGTAGCTGTGAG ATCCTCAGGGCCTGCTGTTGTCATTATGACCAATAAGCAAGGGGCCCAGAGAGCCTAAGAGACCTGCCCAGCACCGCACAGCCAGAACGG GGCGCAGACCCAAAGCAGGAGTGTCCCCTCGAGACAAAGCCTCCGCCGAGGCCGCCGTGACTCCCCGCCCATCAGCAAACCTCTCCGAGC ACCTCTGTGTGCCAGGCACTGTGGAGTGACCCCAAGAGGTGGAGACCACTTCCCCGGCTGCTCTAGGCAGCTCCGTCCCACGGAGCCAGC GGGAAGCCAGCCACCGCGAAGCCGTGCCCCGGA >52697_52697_6_MED21-PIP5K1C_MED21_chr12_27175554_ENST00000546323_PIP5K1C_chr19_3661999_ENST00000537021_length(amino acids)=650AA_BP=23 MASVCCGRNMADRLTQLQDAVNSTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVA FRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGG KNIRVVVMNNILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLL LGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLE HTWKALVHDGDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTL EDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVP KEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDEEDAPATDIYFWRLWGPHAPTWPWRREGRAACLCPYPPHVVTPFPGTGLCA SWSPDGTGGLGAMSCCVSVS -------------------------------------------------------------- >52697_52697_7_MED21-PIP5K1C_MED21_chr12_27175554_ENST00000546323_PIP5K1C_chr19_3661999_ENST00000539785_length(transcript)=2071nt_BP=76nt AGCTGTTTTGGCGTCTGTTTGCTGCGGTAGGAACATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCAC CCTGAAGGGTGCCATCCAGCTGGGCATCGGCTACACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTA CGTGGTGGAGAGCATCTTCTTCCCCAGCGAAGGCAGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACC TGTCGCCTTCCGCTACTTCCGGGAGCTCTTTGGGATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTC CAACCCGGGCGCCAGTGGCTCCCTCTTCTACGTCACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCT GCAGAAGCTGCTCCCTGGCTACTACATGAACCTCAACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTC GGGGGGCAAGAACATCCGCGTCGTGGTCATGAACAACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCAC CTACAAGCGGCGCGCCAGCAAGAAGGAGAAGGAGAAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCT CCTGCTGGACGCCGACACCTTCAGCGCCCTGGTCAAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAG CCTGCTGCTGGGCGTGCACAACATCGACCAGCACGAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGT GGGCCAGAAGGCGCTCTACTCCACGGCCATGGAGTCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGG CGGGATCCCCGCTGTGAACGGCCGCGGGGAGCGGCTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAA ACTGGAGCACACCTGGAAGGCCCTCGTCCACGATGGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTT CATGAGCAACACGGTCTTTCGGAAGAACTCCTCCCTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACC GCTGGGGCCCACCGCTGCCTTCTCGGCCAGCCAGATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCC CACGCTGGAGGACGAAGGCCGGCCCGACCTCCTGCCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCT GTCATCCACATCCCTCTCCATTCCTGAGCGGTCCCCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACA GGATGGCAGGCCGCAGGAGGAGCCACCCGCGGAAGAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGT GGTCCCCAAAGAGGAGGACGCAGGGGTGGAGGCTTCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGA CGAGGAGGGCGCACCTGCCAGCCAGGCCTCGGACGAGGAGGACGCGCCCGCCACCGACATCTACTTTTAATTTCTATGCAGCCCCCGACC CAGAGCCGAGCTCCACTTCTGCTCCGGCTGCCCCCGAAGGCGCTGCCCACCCCGCTGAGGCCCAGAGCTCGGGAGATGCCCGCCTCGCCG CCCCACCGGACCTCGTCCTCCCCCTGCACGGATGCCGACGGCCGGGCCCCTCCCCGACAAGCCTCCCAGGGCCCCGGCACCCCGGTCGGC AGCCTGCCCCTGTGAGACCCACCCTCCCGAGCGGCCAATCGCATTTGAGTCCTTATTTGGCACAGAGACGGAAGCACGTGTGTGCCGTTT T >52697_52697_7_MED21-PIP5K1C_MED21_chr12_27175554_ENST00000546323_PIP5K1C_chr19_3661999_ENST00000539785_length(amino acids)=590AA_BP=23 MASVCCGRNMADRLTQLQDAVNSTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVA FRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGG KNIRVVVMNNILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLL LGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLE HTWKALVHDGDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTL EDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVP KEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDEEDAPATDIYF -------------------------------------------------------------- >52697_52697_8_MED21-PIP5K1C_MED21_chr12_27175554_ENST00000546323_PIP5K1C_chr19_3661999_ENST00000589578_length(transcript)=2790nt_BP=76nt AGCTGTTTTGGCGTCTGTTTGCTGCGGTAGGAACATGGCGGATCGGCTCACGCAGCTTCAGGACGCTGTGAATTCGACCACCTCCTCCAC CCTGAAGGGTGCCATCCAGCTGGGCATCGGCTACACCGTGGGCCACCTGAGCTCCAAGCCCGAACGCGACGTGCTCATGCAGGACTTCTA CGTGGTGGAGAGCATCTTCTTCCCCAGCGAAGGCAGCAACCTCACCCCCGCCCACCACTTCCAGGACTTCCGCTTCAAGACCTATGCACC TGTCGCCTTCCGCTACTTCCGGGAGCTCTTTGGGATCCGGCCAGATGATTACTTGTACTCCCTGTGCAATGAGCCGCTGATCGAGCTGTC CAACCCGGGCGCCAGTGGCTCCCTCTTCTACGTCACCAGCGACGACGAGTTCATCATCAAGACCGTCATGCACAAGGAGGCCGAGTTCCT GCAGAAGCTGCTCCCTGGCTACTACATGAACCTCAACCAGAACCCGCGGACGCTGCTGCCCAAGTTCTATGGGCTGTACTGCGTGCAGTC GGGGGGCAAGAACATCCGCGTCGTGGTCATGAACAACATCCTGCCCCGCGTGGTCAAGATGCACCTCAAGTTCGACCTCAAGGGCTCCAC CTACAAGCGGCGCGCCAGCAAGAAGGAGAAGGAGAAGAGCTTCCCCACCTACAAGGACCTGGACTTCATGCAGGACATGCCCGAGGGGCT CCTGCTGGACGCCGACACCTTCAGCGCCCTGGTCAAGACGCTGCAGCGGGACTGCCTGGTCCTGGAAAGTTTCAAGATCATGGACTACAG CCTGCTGCTGGGCGTGCACAACATCGACCAGCACGAGCGCGAGCGGCAGGCGCAGGGCGCCCAGAGCACCTCAGATGAGAAGCGGCCTGT GGGCCAGAAGGCGCTCTACTCCACGGCCATGGAGTCCATCCAGGGTGGCGCCGCGCGCGGGGAGGCCATCGAATCGGATGACACGATGGG CGGGATCCCCGCTGTGAACGGCCGCGGGGAGCGGCTGCTGCTGCACATTGGCATCATCGACATCCTGCAGTCCTACAGGTTCATCAAGAA ACTGGAGCACACCTGGAAGGCCCTCGTCCACGATGGGGACACGGTGTCCGTCCACCGCCCCAGCTTCTATGCCGAGCGCTTTTTCAAGTT CATGAGCAACACGGTCTTTCGGAAGAACTCCTCCCTGAAGTCCTCGCCCTCCAAGAAGGGGCGCGGCGGAGCCTTGCTAGCTGTGAAACC GCTGGGGCCCACCGCTGCCTTCTCGGCCAGCCAGATCCCTAGCGAGCGGGAGGAGGCCCAGTACGACCTGCGGGGGGCCCGCAGCTACCC CACGCTGGAGGACGAAGGCCGGCCCGACCTCCTGCCCTGCACGCCACCTTCTTTCGAAGAAGCCACTACAGCCTCCATTGCCACGACTCT GTCATCCACATCCCTCTCCATTCCTGAGCGGTCCCCCTCGGAGACGTCGGAGCAGCCGCGGTACAGGCGGCGCACACAGTCGTCTGGACA GGATGGCAGGCCGCAGGAGGAGCCACCCGCGGAAGAGGATCTGCAGCAGATTACAGTGCAGGTGGAGCCTGCGTGCAGCGTGGAGATTGT GGTCCCCAAAGAGGAGGACGCAGGGGTGGAGGCTTCCCCGGCCGGTGCCTCTGCTGCTGTTGAAGTAGAAACTGCCAGCCAGGCCTCAGA CGAGGAGGGCGCACCTGCCAGCCAGGCCTCGGACGAGGAGGACGCGCCCGCCACCGACATCTACTTTTTCACGGATGGGAGGTACTGGAT TTACTCTCCCCGCCATCGCCGACTGCGGGCCGTGACGCTGAGCGCCTCGGGGACTGTAAGTGACCGCAGCCGGCCACCCTGGGGAGAAGG GGCAGTGCCCCTCGGGCAGCAGGGAGCCGCAGGTCCCCGGCCGGAAGCTCAGTGTCTGACGTCAGTTGTTTTCCAGAAGGGCTTTGGGTA AATCACGGCTGCAATTGAGGTCAGCCACGCTGGCCCCGGACCAGGCGCTGGGCTGCATGCGTCACTGGGAATGTCATTCGGTCCCACGTC GAACCGGGCGCTCCATAGGGCAGCACCATCACCAGGTGCACAGCTGAGGCCCAGGGTCTGCTTCGGACCCCGGCCAGACCCCAGCGAGCC CCTCTCTGCCCCTGGACCCAGCCCTCTCGTGTCAGGGTGTCTTGGGTGGACGCTTCTCACTCGTGCAGACCTGGCTGCCCGTGGCCCCGC TGGCTGCACAGGGGAGGTTGCACAGGTCAGCAGAGTGGCTGCAGGGCCGGGCTCTGAACCGCAGGGCCATGGAGACGGGGAGGAGATGGT CTCTCCACACCCACCTCACAGATGGAGGCGCTGAGGCCTCGGCTCCCCTGGGAGCCTGGGAGACCACACGGTTTAGTCAAAATCCAGATC CCCAAGCTCTCAAGGAGGTCCCCCTGGGACGCCACATGGGCCCCACGTAGCTGTGAGATCCTCAGGGCCTGCTGTTGTCATTATGACCAA TAAGCAAGGGGCCCAGAGAGCCTAAGAGACCTGCCCAGCACCGCACAGCCAGAACGGGGCGCAGACCCAAAGCAGGAGTGTCCCCTCGAG ACAAAGCCTCCGCCGAGGCCGCCGTGACTCCCCGCCCATCAGCAAACCTCTCCGAGCACCTCTGTGTGCCAGGCACTGTGGAGTGACCCC AAGAGGTGGAGACCACTTCCCCGGCTGCTCTAGGCAGCTCCGTCCCACGGAGCCAGCGGGAAGCCAGCCACCGCGAAGCCGTGCCCCGGA >52697_52697_8_MED21-PIP5K1C_MED21_chr12_27175554_ENST00000546323_PIP5K1C_chr19_3661999_ENST00000589578_length(amino acids)=657AA_BP=23 MASVCCGRNMADRLTQLQDAVNSTTSSTLKGAIQLGIGYTVGHLSSKPERDVLMQDFYVVESIFFPSEGSNLTPAHHFQDFRFKTYAPVA FRYFRELFGIRPDDYLYSLCNEPLIELSNPGASGSLFYVTSDDEFIIKTVMHKEAEFLQKLLPGYYMNLNQNPRTLLPKFYGLYCVQSGG KNIRVVVMNNILPRVVKMHLKFDLKGSTYKRRASKKEKEKSFPTYKDLDFMQDMPEGLLLDADTFSALVKTLQRDCLVLESFKIMDYSLL LGVHNIDQHERERQAQGAQSTSDEKRPVGQKALYSTAMESIQGGAARGEAIESDDTMGGIPAVNGRGERLLLHIGIIDILQSYRFIKKLE HTWKALVHDGDTVSVHRPSFYAERFFKFMSNTVFRKNSSLKSSPSKKGRGGALLAVKPLGPTAAFSASQIPSEREEAQYDLRGARSYPTL EDEGRPDLLPCTPPSFEEATTASIATTLSSTSLSIPERSPSETSEQPRYRRRTQSSGQDGRPQEEPPAEEDLQQITVQVEPACSVEIVVP KEEDAGVEASPAGASAAVEVETASQASDEEGAPASQASDEEDAPATDIYFFTDGRYWIYSPRHRRLRAVTLSASGTVSDRSRPPWGEGAV PLGQQGAAGPRPEAQCLTSVVFQKGFG -------------------------------------------------------------- |
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Fusion Gene PPI Analysis for MED21-PIP5K1C |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160) |
| Hgene | Hgene's interactors | Tgene | Tgene's interactors |
| - Retained PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost PPIs in in-frame fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| - Retained PPIs, but lost function due to frame-shift fusion. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs for MED21-PIP5K1C |
| Drugs targeting genes involved in this fusion gene. (DrugBank Version 5.1.8 2021-05-08) |
| Partner | Gene | UniProtAcc | DrugBank ID | Drug name | Drug activity | Drug type | Drug status |
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Related Diseases for MED21-PIP5K1C |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
| Tgene | C1969655 | LETHAL CONGENITAL CONTRACTURAL SYNDROME 3 | 1 | CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT |
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