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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:NPEPPS-FAM117A (FusionGDB2 ID:HG9520TG81558)

Fusion Gene Summary for NPEPPS-FAM117A

check button Fusion gene summary
Fusion gene informationFusion gene name: NPEPPS-FAM117A
Fusion gene ID: hg9520tg81558
HgeneTgene
Gene symbol

NPEPPS

FAM117A

Gene ID

9520

81558

Gene nameaminopeptidase puromycin sensitivefamily with sequence similarity 117 member A
SynonymsAAP-S|MP100|PSA-
Cytomap('NPEPPS')('FAM117A')

17q21.32

17q21.33

Type of geneprotein-codingprotein-coding
Descriptionpuromycin-sensitive aminopeptidasecytosol alanyl aminopeptidasemetalloproteinase MP100protein FAM117AC/EBP-induced protein
Modification date2020031320200313
UniProtAcc.

Q9C073

Ensembl transtripts involved in fusion geneENST00000525037, ENST00000322157, 
ENST00000530173, ENST00000544660, 
Fusion gene scores* DoF score18 X 9 X 9=14588 X 4 X 6=192
# samples 1910
** MAII scorelog2(19/1458*10)=-2.93991939599599
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(10/192*10)=-0.941106310946431
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: NPEPPS [Title/Abstract] AND FAM117A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointNPEPPS(45623359)-FAM117A(47810082), # samples:3
Anticipated loss of major functional domain due to fusion event.NPEPPS-FAM117A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NPEPPS-FAM117A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
NPEPPS-FAM117A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
NPEPPS-FAM117A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneNPEPPS

GO:0071456

cellular response to hypoxia

21056661


check buttonFusion gene breakpoints across NPEPPS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across FAM117A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-A2-A04W-01ANPEPPSchr17

45623359

+FAM117Achr17

47810082

-
ChimerDB4BRCATCGA-A2-A04WNPEPPSchr17

45623359

+FAM117Achr17

47810082

-


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Fusion Gene ORF analysis for NPEPPS-FAM117A

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000525037ENST00000240364NPEPPSchr17

45623359

+FAM117Achr17

47810082

-
3UTR-5UTRENST00000525037ENST00000513602NPEPPSchr17

45623359

+FAM117Achr17

47810082

-
3UTR-5UTRENST00000525037ENST00000514018NPEPPSchr17

45623359

+FAM117Achr17

47810082

-
5CDS-5UTRENST00000322157ENST00000513602NPEPPSchr17

45623359

+FAM117Achr17

47810082

-
5CDS-5UTRENST00000322157ENST00000514018NPEPPSchr17

45623359

+FAM117Achr17

47810082

-
5CDS-5UTRENST00000530173ENST00000513602NPEPPSchr17

45623359

+FAM117Achr17

47810082

-
5CDS-5UTRENST00000530173ENST00000514018NPEPPSchr17

45623359

+FAM117Achr17

47810082

-
5CDS-5UTRENST00000544660ENST00000513602NPEPPSchr17

45623359

+FAM117Achr17

47810082

-
5CDS-5UTRENST00000544660ENST00000514018NPEPPSchr17

45623359

+FAM117Achr17

47810082

-
In-frameENST00000322157ENST00000240364NPEPPSchr17

45623359

+FAM117Achr17

47810082

-
In-frameENST00000530173ENST00000240364NPEPPSchr17

45623359

+FAM117Achr17

47810082

-
In-frameENST00000544660ENST00000240364NPEPPSchr17

45623359

+FAM117Achr17

47810082

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000530173NPEPPSchr1745623359+ENST00000240364FAM117Achr1747810082-2447358301523497
ENST00000322157NPEPPSchr1745623359+ENST00000240364FAM117Achr1747810082-2666577661742558
ENST00000544660NPEPPSchr1745623359+ENST00000240364FAM117Achr1747810082-2403314131479488

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000530173ENST00000240364NPEPPSchr1745623359+FAM117Achr1747810082-0.120096850.8799032
ENST00000322157ENST00000240364NPEPPSchr1745623359+FAM117Achr1747810082-0.141113310.85888666
ENST00000544660ENST00000240364NPEPPSchr1745623359+FAM117Achr1747810082-0.120349040.8796509

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Fusion Genomic Features for NPEPPS-FAM117A


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for NPEPPS-FAM117A


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:45623359/chr17:47810082)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.FAM117A

Q9C073

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneFAM117Achr17:45623359chr17:47810082ENST0000024036408149_17565454.0Coiled coilOntology_term=ECO:0000255
TgeneFAM117Achr17:45623359chr17:47810082ENST0000024036408402_44465454.0Compositional biasNote=Pro-rich

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneNPEPPSchr17:45623359chr17:47810082ENST00000322157+223726_730113920.0MotifNuclear localization signal
HgeneNPEPPSchr17:45623359chr17:47810082ENST00000322157+223316_320113920.0RegionSubstrate binding


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Fusion Gene Sequence for NPEPPS-FAM117A


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>59879_59879_1_NPEPPS-FAM117A_NPEPPS_chr17_45623359_ENST00000322157_FAM117A_chr17_47810082_ENST00000240364_length(transcript)=2666nt_BP=577nt
GGGCGCGCCCGGCCGGCGGGGCCGCGCACGCAGCCGCCGCCACCACTTCCCCCTCTCCCTCCCTCCTTGCGGGCCCTCCTCCCCTTCCCT
CCCCTCCGCCCCCTTCCCCGTAGGCAGCCCGCCCGCCAGTCCGCCCGCACCGCCTCCTTCCCAGCCCCTAGCGCTCCGGCTGGGTCTCTC
CCCCGCCCCCCAGGCTCCCCCGGTCGCTCTCCTCCGGCGGTCGCCCGCGCTCGGTGGATGTGGCTGGCAGCTGCCGCCCCCTCCCTCGCT
CGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGC
CTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTG
CTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGAT
ATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGCCAGCGTCCCATGCTCGGTGGCCCCAGAAAAGTCAGTGTGTAGGCCTCAGCCA
CTTCAGGTCCGGCGTACATTCTCCCTGGACACCATCCTCAGCTCCTACCTTCTGGGCCAGTGGCCACGAGATGCTGATGGGGCCTTCACC
TGCTGCACCAATGACAAGGCCACCCAGACGCCCCTGTCCTGGCAAGAGCTAGAAGGTGAGCGTGCCAGTTCCTGTGCACACAAGCGCTCA
GCATCCTGGGGCAGCACAGACCACCGAAAAGAGATTTCCAAGTTGAAGCAACAACTGCAGAGGACGAAGCTGAGCCGCAGTGGGAAAGAG
AAGGAGCGAGGTTCACCACTCCTAGGGGACCACGCAGTGCGGGGAGCACTGAGGGCGTCCCCTCCCAGCTTCCCCTCAGGGTCCCCTGTC
TTGCGACTCAGCCCCTGCCTGCACAGGAGCCTGGAAGGGCTCAACCAAGAGCTGGAGGAGGTATTTGTGAAGGAGCAGGGAGAAGAGGAG
CTGCTGAGGATCCTTGATATCCCTGATGGGCACCGGGCCCCAGCTCCTCCCCAGAGTGGCAGCTGTGATCATCCCCTCCTCCTCCTGGAG
CCTGGCAACCTTGCCAGCTCTCCTTCCATGTCCTTGGCATCTCCCCAGCCTTGTGGCCTGGCCAGTCATGAGGAACATCGGGGTGCCGCC
GAGGAGCTGGCATCCACCCCCAACGACAAAGCCTCCTCTCCAGGACACCCAGCCTTTCTTGAAGATGGCAGCCCATCTCCAGTCCTTGCC
TTTGCTGCCTCCCCTCGACCTAATCATAGCTACATCTTCAAACGGGAGCCCCCAGAAGGCTGTGAGAAAGTGCGTGTGTTTGAAGAAGCC
ACGTCTCCAGGTCCTGACCTGGCCTTCCTGACTTCCTGTCCTGACAAGAACAAAGTCCATTTCAACCCGACTGGCTCAGCCTTCTGCCCC
GTCAACCTGATGAAGCCCCTCTTCCCCGGCATGGGCTTCATCTTCCGTAACTGCCCCTCAAACCCGGGATCTCCCCTTCCCCCGGCCAGC
CCCAGGCCACCACCTCGGAAGGATCCGGAAGCCTCCAAGGCCTCCCCACTGCCATTCGAGCCATGGCAGCGCACCCCACCATCAGAAGAG
CCTGTGCTTTTCCAGAGCTCCCTGATGGTCTGAGGGTCCCACCCCTGCCCCACTTTACCATAGAGACCAGTGCCTTGGTGGCAGGTCCCT
CCCCAGGTCCCCTGAGATGGGGTATGGAGGGGCCCTTCCCTCTCGGCCTTCGAGCACTTTCTTTCACTTACTGTGTCAAAGCCCTGGGTC
CTCTTTTTGATGGGCACCGGCCCCTCTGAACGTGATGGGACCTGCCTTCTCCACTAGTAGCTGGGCAGCTCACAATTCACACCTGTGTAC
CTGCCACATCCCTCACTTGGTGGAAAACACCCAGAAGGTCTTGAGTCCCCCACCCCTGGGTGTCAGTCCAAATGACTGTATAGGAGGCCC
TTATTTTTGTCACAGAGCAAGCTGGCCATGAACGAAGGAGAGAAGACGCCACAGATTTCCTTCCCTCTCCTCCAGGAGACCATAAGATAG
ATCCCCCATCCTCTCAGCCCTATTCCCATGCCTCCCTCTCATTGGAGGAGCTGACCAAAGCAGCCCTAACGGGCCATAACACTTGACCAA
TTCAGCTGCTGGCAGAGGGAGGAAACAAGTGTTTTCCCAAGTGGCATTTTCATCTCGCTTTCACCCTGACTAAAGATTGTCTTAAGTAGC
AGCCCAGCCCGCCCAGCCCCAGGTGGGTAGTGGGGAGGAGAGCTGGCATTCCTCCAGGTGGCAAATGGCGACTCTATACTCTCCGCCCGC
CCCAGGGCTGGATGGATTAGAAAAATGCCTATTTTTCTTGTATCGATGTAGAGACTCTATTTTCTCCCAAAGACACTATTTTTGCAGCTG
TTTGAAGTTTGTATATTTTCCGTACTGCAGAGCTTACACAAAATTGAAGAATGTTAATGTTCGAGTTTTCTTATCTTGTGTTTAGAGGTT
GTTTTTTGCAGATCTTGGTGTTAATAGACCAAATAAATAAATAAATATTCCCAGCA

>59879_59879_1_NPEPPS-FAM117A_NPEPPS_chr17_45623359_ENST00000322157_FAM117A_chr17_47810082_ENST00000240364_length(amino acids)=558AA_BP=28
MRALLPFPPLRPLPRRQPARQSARTASFPAPSAPAGSLPRPPGSPGRSPPAVARARWMWLAAAAPSLARRLLFLGPPPPPLLLLVFSRSS
RRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDIITASYAPEGDEASVPCSVAPE
KSVCRPQPLQVRRTFSLDTILSSYLLGQWPRDADGAFTCCTNDKATQTPLSWQELEGERASSCAHKRSASWGSTDHRKEISKLKQQLQRT
KLSRSGKEKERGSPLLGDHAVRGALRASPPSFPSGSPVLRLSPCLHRSLEGLNQELEEVFVKEQGEEELLRILDIPDGHRAPAPPQSGSC
DHPLLLLEPGNLASSPSMSLASPQPCGLASHEEHRGAAEELASTPNDKASSPGHPAFLEDGSPSPVLAFAASPRPNHSYIFKREPPEGCE
KVRVFEEATSPGPDLAFLTSCPDKNKVHFNPTGSAFCPVNLMKPLFPGMGFIFRNCPSNPGSPLPPASPRPPPRKDPEASKASPLPFEPW
QRTPPSEEPVLFQSSLMV

--------------------------------------------------------------
>59879_59879_2_NPEPPS-FAM117A_NPEPPS_chr17_45623359_ENST00000530173_FAM117A_chr17_47810082_ENST00000240364_length(transcript)=2447nt_BP=358nt
AAGTTACGGAAGAGTCAAGGCTGGGACCTCATGGCATCATTTTCCATGGATTGCTCTCCAAGTTTTTGTGTTCCTGGCCTTTGGAACCCC
TTCATCATATTCCGCAGCCGCTCCTCTCGCCGCCGCCTCCACAGCCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTG
CCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCCCGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCC
CAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGATATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGCC
AGCGTCCCATGCTCGGTGGCCCCAGAAAAGTCAGTGTGTAGGCCTCAGCCACTTCAGGTCCGGCGTACATTCTCCCTGGACACCATCCTC
AGCTCCTACCTTCTGGGCCAGTGGCCACGAGATGCTGATGGGGCCTTCACCTGCTGCACCAATGACAAGGCCACCCAGACGCCCCTGTCC
TGGCAAGAGCTAGAAGGTGAGCGTGCCAGTTCCTGTGCACACAAGCGCTCAGCATCCTGGGGCAGCACAGACCACCGAAAAGAGATTTCC
AAGTTGAAGCAACAACTGCAGAGGACGAAGCTGAGCCGCAGTGGGAAAGAGAAGGAGCGAGGTTCACCACTCCTAGGGGACCACGCAGTG
CGGGGAGCACTGAGGGCGTCCCCTCCCAGCTTCCCCTCAGGGTCCCCTGTCTTGCGACTCAGCCCCTGCCTGCACAGGAGCCTGGAAGGG
CTCAACCAAGAGCTGGAGGAGGTATTTGTGAAGGAGCAGGGAGAAGAGGAGCTGCTGAGGATCCTTGATATCCCTGATGGGCACCGGGCC
CCAGCTCCTCCCCAGAGTGGCAGCTGTGATCATCCCCTCCTCCTCCTGGAGCCTGGCAACCTTGCCAGCTCTCCTTCCATGTCCTTGGCA
TCTCCCCAGCCTTGTGGCCTGGCCAGTCATGAGGAACATCGGGGTGCCGCCGAGGAGCTGGCATCCACCCCCAACGACAAAGCCTCCTCT
CCAGGACACCCAGCCTTTCTTGAAGATGGCAGCCCATCTCCAGTCCTTGCCTTTGCTGCCTCCCCTCGACCTAATCATAGCTACATCTTC
AAACGGGAGCCCCCAGAAGGCTGTGAGAAAGTGCGTGTGTTTGAAGAAGCCACGTCTCCAGGTCCTGACCTGGCCTTCCTGACTTCCTGT
CCTGACAAGAACAAAGTCCATTTCAACCCGACTGGCTCAGCCTTCTGCCCCGTCAACCTGATGAAGCCCCTCTTCCCCGGCATGGGCTTC
ATCTTCCGTAACTGCCCCTCAAACCCGGGATCTCCCCTTCCCCCGGCCAGCCCCAGGCCACCACCTCGGAAGGATCCGGAAGCCTCCAAG
GCCTCCCCACTGCCATTCGAGCCATGGCAGCGCACCCCACCATCAGAAGAGCCTGTGCTTTTCCAGAGCTCCCTGATGGTCTGAGGGTCC
CACCCCTGCCCCACTTTACCATAGAGACCAGTGCCTTGGTGGCAGGTCCCTCCCCAGGTCCCCTGAGATGGGGTATGGAGGGGCCCTTCC
CTCTCGGCCTTCGAGCACTTTCTTTCACTTACTGTGTCAAAGCCCTGGGTCCTCTTTTTGATGGGCACCGGCCCCTCTGAACGTGATGGG
ACCTGCCTTCTCCACTAGTAGCTGGGCAGCTCACAATTCACACCTGTGTACCTGCCACATCCCTCACTTGGTGGAAAACACCCAGAAGGT
CTTGAGTCCCCCACCCCTGGGTGTCAGTCCAAATGACTGTATAGGAGGCCCTTATTTTTGTCACAGAGCAAGCTGGCCATGAACGAAGGA
GAGAAGACGCCACAGATTTCCTTCCCTCTCCTCCAGGAGACCATAAGATAGATCCCCCATCCTCTCAGCCCTATTCCCATGCCTCCCTCT
CATTGGAGGAGCTGACCAAAGCAGCCCTAACGGGCCATAACACTTGACCAATTCAGCTGCTGGCAGAGGGAGGAAACAAGTGTTTTCCCA
AGTGGCATTTTCATCTCGCTTTCACCCTGACTAAAGATTGTCTTAAGTAGCAGCCCAGCCCGCCCAGCCCCAGGTGGGTAGTGGGGAGGA
GAGCTGGCATTCCTCCAGGTGGCAAATGGCGACTCTATACTCTCCGCCCGCCCCAGGGCTGGATGGATTAGAAAAATGCCTATTTTTCTT
GTATCGATGTAGAGACTCTATTTTCTCCCAAAGACACTATTTTTGCAGCTGTTTGAAGTTTGTATATTTTCCGTACTGCAGAGCTTACAC
AAAATTGAAGAATGTTAATGTTCGAGTTTTCTTATCTTGTGTTTAGAGGTTGTTTTTTGCAGATCTTGGTGTTAATAGACCAAATAAATA
AATAAATATTCCCAGCA

>59879_59879_2_NPEPPS-FAM117A_NPEPPS_chr17_45623359_ENST00000530173_FAM117A_chr17_47810082_ENST00000240364_length(amino acids)=497AA_BP=109
MASFSMDCSPSFCVPGLWNPFIIFRSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIV
MNCADIDIITASYAPEGDEASVPCSVAPEKSVCRPQPLQVRRTFSLDTILSSYLLGQWPRDADGAFTCCTNDKATQTPLSWQELEGERAS
SCAHKRSASWGSTDHRKEISKLKQQLQRTKLSRSGKEKERGSPLLGDHAVRGALRASPPSFPSGSPVLRLSPCLHRSLEGLNQELEEVFV
KEQGEEELLRILDIPDGHRAPAPPQSGSCDHPLLLLEPGNLASSPSMSLASPQPCGLASHEEHRGAAEELASTPNDKASSPGHPAFLEDG
SPSPVLAFAASPRPNHSYIFKREPPEGCEKVRVFEEATSPGPDLAFLTSCPDKNKVHFNPTGSAFCPVNLMKPLFPGMGFIFRNCPSNPG
SPLPPASPRPPPRKDPEASKASPLPFEPWQRTPPSEEPVLFQSSLMV

--------------------------------------------------------------
>59879_59879_3_NPEPPS-FAM117A_NPEPPS_chr17_45623359_ENST00000544660_FAM117A_chr17_47810082_ENST00000240364_length(transcript)=2403nt_BP=314nt
CCTCGCTCGCCGCCTGCTCTTCCTCGGCCCTCCGCCTCCTCCCCTCCTCCTTCTCGTCTTCAGCCGCTCCTCTCGCCGCCGCCTCCACAG
CCTGGGCCTCGCCGCGATGCCGGAGAAGAGGCCCTTCGAGCGGCTGCCTGCCGATGTCTCCCCCATCAACTACAGCCTTTGCCTCAAGCC
CGACTTGCTGGACTTCACCTTCGAGGGCAAGCTGGAGGCCGCCGCCCAGGTGAGGCAGGCGACTAATCAGATTGTGATGAATTGTGCTGA
TATTGATATTATTACAGCTTCATATGCACCAGAAGGAGATGAAGCCAGCGTCCCATGCTCGGTGGCCCCAGAAAAGTCAGTGTGTAGGCC
TCAGCCACTTCAGGTCCGGCGTACATTCTCCCTGGACACCATCCTCAGCTCCTACCTTCTGGGCCAGTGGCCACGAGATGCTGATGGGGC
CTTCACCTGCTGCACCAATGACAAGGCCACCCAGACGCCCCTGTCCTGGCAAGAGCTAGAAGGTGAGCGTGCCAGTTCCTGTGCACACAA
GCGCTCAGCATCCTGGGGCAGCACAGACCACCGAAAAGAGATTTCCAAGTTGAAGCAACAACTGCAGAGGACGAAGCTGAGCCGCAGTGG
GAAAGAGAAGGAGCGAGGTTCACCACTCCTAGGGGACCACGCAGTGCGGGGAGCACTGAGGGCGTCCCCTCCCAGCTTCCCCTCAGGGTC
CCCTGTCTTGCGACTCAGCCCCTGCCTGCACAGGAGCCTGGAAGGGCTCAACCAAGAGCTGGAGGAGGTATTTGTGAAGGAGCAGGGAGA
AGAGGAGCTGCTGAGGATCCTTGATATCCCTGATGGGCACCGGGCCCCAGCTCCTCCCCAGAGTGGCAGCTGTGATCATCCCCTCCTCCT
CCTGGAGCCTGGCAACCTTGCCAGCTCTCCTTCCATGTCCTTGGCATCTCCCCAGCCTTGTGGCCTGGCCAGTCATGAGGAACATCGGGG
TGCCGCCGAGGAGCTGGCATCCACCCCCAACGACAAAGCCTCCTCTCCAGGACACCCAGCCTTTCTTGAAGATGGCAGCCCATCTCCAGT
CCTTGCCTTTGCTGCCTCCCCTCGACCTAATCATAGCTACATCTTCAAACGGGAGCCCCCAGAAGGCTGTGAGAAAGTGCGTGTGTTTGA
AGAAGCCACGTCTCCAGGTCCTGACCTGGCCTTCCTGACTTCCTGTCCTGACAAGAACAAAGTCCATTTCAACCCGACTGGCTCAGCCTT
CTGCCCCGTCAACCTGATGAAGCCCCTCTTCCCCGGCATGGGCTTCATCTTCCGTAACTGCCCCTCAAACCCGGGATCTCCCCTTCCCCC
GGCCAGCCCCAGGCCACCACCTCGGAAGGATCCGGAAGCCTCCAAGGCCTCCCCACTGCCATTCGAGCCATGGCAGCGCACCCCACCATC
AGAAGAGCCTGTGCTTTTCCAGAGCTCCCTGATGGTCTGAGGGTCCCACCCCTGCCCCACTTTACCATAGAGACCAGTGCCTTGGTGGCA
GGTCCCTCCCCAGGTCCCCTGAGATGGGGTATGGAGGGGCCCTTCCCTCTCGGCCTTCGAGCACTTTCTTTCACTTACTGTGTCAAAGCC
CTGGGTCCTCTTTTTGATGGGCACCGGCCCCTCTGAACGTGATGGGACCTGCCTTCTCCACTAGTAGCTGGGCAGCTCACAATTCACACC
TGTGTACCTGCCACATCCCTCACTTGGTGGAAAACACCCAGAAGGTCTTGAGTCCCCCACCCCTGGGTGTCAGTCCAAATGACTGTATAG
GAGGCCCTTATTTTTGTCACAGAGCAAGCTGGCCATGAACGAAGGAGAGAAGACGCCACAGATTTCCTTCCCTCTCCTCCAGGAGACCAT
AAGATAGATCCCCCATCCTCTCAGCCCTATTCCCATGCCTCCCTCTCATTGGAGGAGCTGACCAAAGCAGCCCTAACGGGCCATAACACT
TGACCAATTCAGCTGCTGGCAGAGGGAGGAAACAAGTGTTTTCCCAAGTGGCATTTTCATCTCGCTTTCACCCTGACTAAAGATTGTCTT
AAGTAGCAGCCCAGCCCGCCCAGCCCCAGGTGGGTAGTGGGGAGGAGAGCTGGCATTCCTCCAGGTGGCAAATGGCGACTCTATACTCTC
CGCCCGCCCCAGGGCTGGATGGATTAGAAAAATGCCTATTTTTCTTGTATCGATGTAGAGACTCTATTTTCTCCCAAAGACACTATTTTT
GCAGCTGTTTGAAGTTTGTATATTTTCCGTACTGCAGAGCTTACACAAAATTGAAGAATGTTAATGTTCGAGTTTTCTTATCTTGTGTTT
AGAGGTTGTTTTTTGCAGATCTTGGTGTTAATAGACCAAATAAATAAATAAATATTCCCAGCA

>59879_59879_3_NPEPPS-FAM117A_NPEPPS_chr17_45623359_ENST00000544660_FAM117A_chr17_47810082_ENST00000240364_length(amino acids)=488AA_BP=100
MLFLGPPPPPLLLLVFSRSSRRRLHSLGLAAMPEKRPFERLPADVSPINYSLCLKPDLLDFTFEGKLEAAAQVRQATNQIVMNCADIDII
TASYAPEGDEASVPCSVAPEKSVCRPQPLQVRRTFSLDTILSSYLLGQWPRDADGAFTCCTNDKATQTPLSWQELEGERASSCAHKRSAS
WGSTDHRKEISKLKQQLQRTKLSRSGKEKERGSPLLGDHAVRGALRASPPSFPSGSPVLRLSPCLHRSLEGLNQELEEVFVKEQGEEELL
RILDIPDGHRAPAPPQSGSCDHPLLLLEPGNLASSPSMSLASPQPCGLASHEEHRGAAEELASTPNDKASSPGHPAFLEDGSPSPVLAFA
ASPRPNHSYIFKREPPEGCEKVRVFEEATSPGPDLAFLTSCPDKNKVHFNPTGSAFCPVNLMKPLFPGMGFIFRNCPSNPGSPLPPASPR
PPPRKDPEASKASPLPFEPWQRTPPSEEPVLFQSSLMV

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Fusion Gene PPI Analysis for NPEPPS-FAM117A


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for NPEPPS-FAM117A


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for NPEPPS-FAM117A


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource