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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:BAG4-WRN (FusionGDB2 ID:HG9530TG7486)

Fusion Gene Summary for BAG4-WRN

check button Fusion gene summary
Fusion gene informationFusion gene name: BAG4-WRN
Fusion gene ID: hg9530tg7486
HgeneTgene
Gene symbol

BAG4

WRN

Gene ID

9530

7486

Gene nameBAG cochaperone 4WRN RecQ like helicase
SynonymsBAG-4|SODDRECQ3|RECQL2|RECQL3
Cytomap('BAG4')('WRN')

8p11.23

8p12

Type of geneprotein-codingprotein-coding
DescriptionBAG family molecular chaperone regulator 4BCL2 associated athanogene 4bcl-2-associated athanogene 4silencer of death domainsWerner syndrome ATP-dependent helicaseDNA helicase, RecQ-like type 3Werner syndrome RecQ like helicaseWerner syndrome, RecQ helicase-likeexonuclease WRNrecQ protein-like 2
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000521282, ENST00000287322, 
ENST00000432471, 
Fusion gene scores* DoF score12 X 5 X 7=4209 X 10 X 7=630
# samples 1511
** MAII scorelog2(15/420*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/630*10)=-2.51784830486262
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: BAG4 [Title/Abstract] AND WRN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointBAG4(38050313)-WRN(31012140), # samples:3
Anticipated loss of major functional domain due to fusion event.BAG4-WRN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
BAG4-WRN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneBAG4

GO:0071356

cellular response to tumor necrosis factor

21712384

TgeneWRN

GO:0000731

DNA synthesis involved in DNA repair

17563354

TgeneWRN

GO:0006259

DNA metabolic process

16622405

TgeneWRN

GO:0006284

base-excision repair

17611195

TgeneWRN

GO:0006974

cellular response to DNA damage stimulus

18203716

TgeneWRN

GO:0006979

response to oxidative stress

17611195

TgeneWRN

GO:0009267

cellular response to starvation

11420665

TgeneWRN

GO:0010225

response to UV-C

17563354

TgeneWRN

GO:0031297

replication fork processing

17115688

TgeneWRN

GO:0032508

DNA duplex unwinding

11735402|26420422

TgeneWRN

GO:0044806

G-quadruplex DNA unwinding

11735402

TgeneWRN

GO:0051345

positive regulation of hydrolase activity

17611195

TgeneWRN

GO:0061820

telomeric D-loop disassembly

15200954|19734539|26420422

TgeneWRN

GO:0071480

cellular response to gamma radiation

21639834

TgeneWRN

GO:0098530

positive regulation of strand invasion

26420422

TgeneWRN

GO:1902570

protein localization to nucleolus

11420665


check buttonFusion gene breakpoints across BAG4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across WRN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-FD-A62O-01ABAG4chr8

38050313

-WRNchr8

31012140

+
ChimerDB4BLCATCGA-FD-A62O-01ABAG4chr8

38050313

+WRNchr8

31012140

+
ChimerDB4BLCATCGA-FD-A62OBAG4chr8

38050313

+WRNchr8

31012139

+


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Fusion Gene ORF analysis for BAG4-WRN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000521282ENST00000298139BAG4chr8

38050313

+WRNchr8

31012140

+
3UTR-3CDSENST00000521282ENST00000298139BAG4chr8

38050313

+WRNchr8

31012139

+
In-frameENST00000287322ENST00000298139BAG4chr8

38050313

+WRNchr8

31012140

+
In-frameENST00000287322ENST00000298139BAG4chr8

38050313

+WRNchr8

31012139

+
intron-3CDSENST00000432471ENST00000298139BAG4chr8

38050313

+WRNchr8

31012140

+
intron-3CDSENST00000432471ENST00000298139BAG4chr8

38050313

+WRNchr8

31012139

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000287322BAG4chr838050313+ENST00000298139WRNchr831012140+19286491481260370
ENST00000287322BAG4chr838050313+ENST00000298139WRNchr831012139+19286491481260370

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000287322ENST00000298139BAG4chr838050313+WRNchr831012140+0.0007371020.99926287
ENST00000287322ENST00000298139BAG4chr838050313+WRNchr831012139+0.0007371020.99926287

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Fusion Genomic Features for BAG4-WRN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
BAG4chr838050313+WRNchr831012139+2.05E-091
BAG4chr838050313+WRNchr831012139+2.05E-091
BAG4chr838050313+WRNchr831012139+2.05E-091
BAG4chr838050313+WRNchr831012139+2.05E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for BAG4-WRN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:38050313/chr8:31012140)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneBAG4chr8:38050313chr8:31012139ENST00000287322+25379_456126458.0DomainBAG
HgeneBAG4chr8:38050313chr8:31012139ENST00000432471+14379_4560422.0DomainBAG
HgeneBAG4chr8:38050313chr8:31012140ENST00000287322+25379_456126458.0DomainBAG
HgeneBAG4chr8:38050313chr8:31012140ENST00000432471+14379_4560422.0DomainBAG
TgeneWRNchr8:38050313chr8:31012139ENST000002981393035507_51012291433.0Compositional biasNote=Poly-Glu
TgeneWRNchr8:38050313chr8:31012140ENST000002981393035507_51012291433.0Compositional biasNote=Poly-Glu
TgeneWRNchr8:38050313chr8:31012139ENST0000029813930351150_122912291433.0DomainHRDC
TgeneWRNchr8:38050313chr8:31012139ENST000002981393035558_72412291433.0DomainHelicase ATP-binding
TgeneWRNchr8:38050313chr8:31012139ENST00000298139303560_22812291433.0DomainNote=3'-5' exonuclease
TgeneWRNchr8:38050313chr8:31012139ENST000002981393035749_89912291433.0DomainHelicase C-terminal
TgeneWRNchr8:38050313chr8:31012140ENST0000029813930351150_122912291433.0DomainHRDC
TgeneWRNchr8:38050313chr8:31012140ENST000002981393035558_72412291433.0DomainHelicase ATP-binding
TgeneWRNchr8:38050313chr8:31012140ENST00000298139303560_22812291433.0DomainNote=3'-5' exonuclease
TgeneWRNchr8:38050313chr8:31012140ENST000002981393035749_89912291433.0DomainHelicase C-terminal
TgeneWRNchr8:38050313chr8:31012139ENST000002981393035668_67112291433.0MotifNote=DEAH box
TgeneWRNchr8:38050313chr8:31012140ENST000002981393035668_67112291433.0MotifNote=DEAH box
TgeneWRNchr8:38050313chr8:31012139ENST000002981393035571_57812291433.0Nucleotide bindingATP
TgeneWRNchr8:38050313chr8:31012140ENST000002981393035571_57812291433.0Nucleotide bindingATP
TgeneWRNchr8:38050313chr8:31012139ENST000002981393035424_47712291433.0RegionNote=2 X 27 AA tandem repeats of H-L-S-P-N-D-N-E-N-D-T-S-Y-V-I-E-S-D-E-D-L-E-M-E-M-L-K
TgeneWRNchr8:38050313chr8:31012140ENST000002981393035424_47712291433.0RegionNote=2 X 27 AA tandem repeats of H-L-S-P-N-D-N-E-N-D-T-S-Y-V-I-E-S-D-E-D-L-E-M-E-M-L-K
TgeneWRNchr8:38050313chr8:31012139ENST000002981393035424_45012291433.0Repeat1
TgeneWRNchr8:38050313chr8:31012139ENST000002981393035451_47712291433.0Repeat2
TgeneWRNchr8:38050313chr8:31012140ENST000002981393035424_45012291433.0Repeat1
TgeneWRNchr8:38050313chr8:31012140ENST000002981393035451_47712291433.0Repeat2


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Fusion Gene Sequence for BAG4-WRN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>8864_8864_1_BAG4-WRN_BAG4_chr8_38050313_ENST00000287322_WRN_chr8_31012139_ENST00000298139_length(transcript)=1928nt_BP=649nt
AACTCCATTGGATAAATGGCGAGGAAACGTATACTCCCTCTTAAGGAACACGGTGTCTTCCTTCGTCTCCGGGTTCCCGAGACCCCAGAG
TCACTGACCTCCGTCCCTCAGCTTTCGGGGTTCGGCAGCAGAAGGGGCGGGCCCGGGCCTGGGATTGGCTGGCGTCGTCCGACCCCCTTC
GCTGCTCTCCATTCGCAATCGCCCGCGGGCGCCTGCGCGATGGGTCGGCCGTGGGGAGCGGGGCGGGAAGCGCTTCAGGGCAGCGGATCC
CATGTCGGCCCTGAGGCGCTCGGGCTACGGCCCCAGTGACGGTCCGTCCTACGGCCGCTACTACGGGCCTGGGGGTGGAGATGTGCCGGT
ACACCCACCTCCACCCTTATATCCTCTTCGCCCTGAACCTCCCCAGCCTCCCATTTCCTGGCGGGTGCGCGGGGGCGGCCCGGCGGAGAC
CACCTGGCTGGGAGAAGGCGGAGGAGGCGATGGCTACTATCCCTCGGGAGGCGCCTGGCCAGAGCCTGGTCGAGCCGGAGGAAGCCACCA
GGAGCAGCCACCATATCCTAGCTACAATTCTAACTATTGGAATTCTACTGCGAGATCTAGGGCTCCTTACCCAAGTACATATCCTGTAAG
ACCAGAATTGCAAGGCCAGACAGACCTCTTTTCAAGTACAAAACCTCAAGAAGAACAGAAGACGAGTCTGGTAGCAAAAAATAAAATATG
CACACTTTCACAGTCTATGGCCATCACATACTCTTTATTCCAAGAAAAGAAGATGCCTTTGAAGAGCATAGCTGAGAGCAGGATTCTGCC
TCTCATGACAATTGGCATGCACTTATCCCAAGCGGTGAAAGCTGGCTGCCCCCTTGATTTGGAGCGAGCAGGCCTGACTCCAGAGGTTCA
GAAGATTATTGCTGATGTTATCCGAAACCCTCCCGTCAACTCAGATATGAGTAAAATTAGCCTAATCAGAATGTTAGTTCCTGAAAACAT
TGACACGTACCTTATCCACATGGCAATTGAGATCCTTAAACATGGTCCTGACAGCGGACTTCAACCTTCATGTGATGTCAACAAAAGGAG
ATGTTTTCCCGGTTCTGAAGAGATCTGTTCAAGTTCTAAGAGAAGCAAGGAAGAAGTAGGCATCAATACTGAGACTTCATCTGCAGAGAG
AAAGAGACGATTACCTGTGTGGTTTGCCAAAGGAAGTGATACCAGCAAGAAATTAATGGACAAAACGAAAAGGGGAGGTCTTTTTAGTTA
AGCTGGCAATTACCAGAACAATTATGTTTCTTGCTGTATTATAAGAGGATAGCTATATTTTATTTCTGAAGAGTAAGGAGTAGTATTTTG
GCTTAAAAATCATTCTAATTACAAAGTTCACTGTTTATTGAAGAACTGGCATCTTAAATCAGCCTTCCGCAATTCATGTAGTTTCTGGGT
CTTCTGGGAGCCTACGTGAGTACATCACCTAACAGAATATTAAATTAGACTTCCTGTAAGATTGCTTTAAGAAACTGTTACTGTCCTGTT
TTCTAATCTCTTTATTAAAACAGTGTATTTGGAAAATGTTATGTGCTCTGATTTGATATAGATAACAGATTAGTAGTTACATGGTAATTA
TGTGATATAAAATATTCATATATTATCAAAATTCTGTTTTGTAAATGTAAGAAAGCATAGTTATTTTACAAATTGTTTTTACTGTCTTTT
GAAGAAGTTCTTAAATACGTTGTTAAATGGTATTAGTTGACCAGGGCAGTGAAAATGAAACCGCATTTTGGGTGCCATTAAATAGGGAAA
AAACATGTAAAAAATGTAAAATGGAGACCAATTGCACTAGGCAAGTGTATATTTTGTATTTTATATACAATTTCTATTATTTTTCAAGTA

>8864_8864_1_BAG4-WRN_BAG4_chr8_38050313_ENST00000287322_WRN_chr8_31012139_ENST00000298139_length(amino acids)=370AA_BP=167
MGLAGVVRPPSLLSIRNRPRAPARWVGRGERGGKRFRAADPMSALRRSGYGPSDGPSYGRYYGPGGGDVPVHPPPPLYPLRPEPPQPPIS
WRVRGGGPAETTWLGEGGGGDGYYPSGGAWPEPGRAGGSHQEQPPYPSYNSNYWNSTARSRAPYPSTYPVRPELQGQTDLFSSTKPQEEQ
KTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKI
SLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLM

--------------------------------------------------------------
>8864_8864_2_BAG4-WRN_BAG4_chr8_38050313_ENST00000287322_WRN_chr8_31012140_ENST00000298139_length(transcript)=1928nt_BP=649nt
AACTCCATTGGATAAATGGCGAGGAAACGTATACTCCCTCTTAAGGAACACGGTGTCTTCCTTCGTCTCCGGGTTCCCGAGACCCCAGAG
TCACTGACCTCCGTCCCTCAGCTTTCGGGGTTCGGCAGCAGAAGGGGCGGGCCCGGGCCTGGGATTGGCTGGCGTCGTCCGACCCCCTTC
GCTGCTCTCCATTCGCAATCGCCCGCGGGCGCCTGCGCGATGGGTCGGCCGTGGGGAGCGGGGCGGGAAGCGCTTCAGGGCAGCGGATCC
CATGTCGGCCCTGAGGCGCTCGGGCTACGGCCCCAGTGACGGTCCGTCCTACGGCCGCTACTACGGGCCTGGGGGTGGAGATGTGCCGGT
ACACCCACCTCCACCCTTATATCCTCTTCGCCCTGAACCTCCCCAGCCTCCCATTTCCTGGCGGGTGCGCGGGGGCGGCCCGGCGGAGAC
CACCTGGCTGGGAGAAGGCGGAGGAGGCGATGGCTACTATCCCTCGGGAGGCGCCTGGCCAGAGCCTGGTCGAGCCGGAGGAAGCCACCA
GGAGCAGCCACCATATCCTAGCTACAATTCTAACTATTGGAATTCTACTGCGAGATCTAGGGCTCCTTACCCAAGTACATATCCTGTAAG
ACCAGAATTGCAAGGCCAGACAGACCTCTTTTCAAGTACAAAACCTCAAGAAGAACAGAAGACGAGTCTGGTAGCAAAAAATAAAATATG
CACACTTTCACAGTCTATGGCCATCACATACTCTTTATTCCAAGAAAAGAAGATGCCTTTGAAGAGCATAGCTGAGAGCAGGATTCTGCC
TCTCATGACAATTGGCATGCACTTATCCCAAGCGGTGAAAGCTGGCTGCCCCCTTGATTTGGAGCGAGCAGGCCTGACTCCAGAGGTTCA
GAAGATTATTGCTGATGTTATCCGAAACCCTCCCGTCAACTCAGATATGAGTAAAATTAGCCTAATCAGAATGTTAGTTCCTGAAAACAT
TGACACGTACCTTATCCACATGGCAATTGAGATCCTTAAACATGGTCCTGACAGCGGACTTCAACCTTCATGTGATGTCAACAAAAGGAG
ATGTTTTCCCGGTTCTGAAGAGATCTGTTCAAGTTCTAAGAGAAGCAAGGAAGAAGTAGGCATCAATACTGAGACTTCATCTGCAGAGAG
AAAGAGACGATTACCTGTGTGGTTTGCCAAAGGAAGTGATACCAGCAAGAAATTAATGGACAAAACGAAAAGGGGAGGTCTTTTTAGTTA
AGCTGGCAATTACCAGAACAATTATGTTTCTTGCTGTATTATAAGAGGATAGCTATATTTTATTTCTGAAGAGTAAGGAGTAGTATTTTG
GCTTAAAAATCATTCTAATTACAAAGTTCACTGTTTATTGAAGAACTGGCATCTTAAATCAGCCTTCCGCAATTCATGTAGTTTCTGGGT
CTTCTGGGAGCCTACGTGAGTACATCACCTAACAGAATATTAAATTAGACTTCCTGTAAGATTGCTTTAAGAAACTGTTACTGTCCTGTT
TTCTAATCTCTTTATTAAAACAGTGTATTTGGAAAATGTTATGTGCTCTGATTTGATATAGATAACAGATTAGTAGTTACATGGTAATTA
TGTGATATAAAATATTCATATATTATCAAAATTCTGTTTTGTAAATGTAAGAAAGCATAGTTATTTTACAAATTGTTTTTACTGTCTTTT
GAAGAAGTTCTTAAATACGTTGTTAAATGGTATTAGTTGACCAGGGCAGTGAAAATGAAACCGCATTTTGGGTGCCATTAAATAGGGAAA
AAACATGTAAAAAATGTAAAATGGAGACCAATTGCACTAGGCAAGTGTATATTTTGTATTTTATATACAATTTCTATTATTTTTCAAGTA

>8864_8864_2_BAG4-WRN_BAG4_chr8_38050313_ENST00000287322_WRN_chr8_31012140_ENST00000298139_length(amino acids)=370AA_BP=167
MGLAGVVRPPSLLSIRNRPRAPARWVGRGERGGKRFRAADPMSALRRSGYGPSDGPSYGRYYGPGGGDVPVHPPPPLYPLRPEPPQPPIS
WRVRGGGPAETTWLGEGGGGDGYYPSGGAWPEPGRAGGSHQEQPPYPSYNSNYWNSTARSRAPYPSTYPVRPELQGQTDLFSSTKPQEEQ
KTSLVAKNKICTLSQSMAITYSLFQEKKMPLKSIAESRILPLMTIGMHLSQAVKAGCPLDLERAGLTPEVQKIIADVIRNPPVNSDMSKI
SLIRMLVPENIDTYLIHMAIEILKHGPDSGLQPSCDVNKRRCFPGSEEICSSSKRSKEEVGINTETSSAERKRRLPVWFAKGSDTSKKLM

--------------------------------------------------------------

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Fusion Gene PPI Analysis for BAG4-WRN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneWRNchr8:38050313chr8:31012139ENST000002981393035987_9931229.01433.0DNA
TgeneWRNchr8:38050313chr8:31012140ENST000002981393035987_9931229.01433.0DNA
TgeneWRNchr8:38050313chr8:31012139ENST0000029813930352_2771229.01433.0WRNIP1
TgeneWRNchr8:38050313chr8:31012140ENST0000029813930352_2771229.01433.0WRNIP1


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for BAG4-WRN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for BAG4-WRN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0043119Werner Syndrome12CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneC0231341Premature aging syndrome1CTD_human
TgeneC0268134DNA Repair-Deficiency1CTD_human
TgeneC1563696DNA Repair-Deficiency Disorders1CTD_human
TgeneC1563697Chromosome Instability Syndromes1CTD_human