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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:IGDCC3-GLDN (FusionGDB2 ID:HG9543TG342035)

Fusion Gene Summary for IGDCC3-GLDN

check button Fusion gene summary
Fusion gene informationFusion gene name: IGDCC3-GLDN
Fusion gene ID: hg9543tg342035
HgeneTgene
Gene symbol

IGDCC3

GLDN

Gene ID

9543

342035

Gene nameimmunoglobulin superfamily DCC subclass member 3gliomedin
SynonymsHsT18880|PUNCCLOM|COLM|CRG-L2|CRGL2|LCCS11|UNC-112|UNC-122
Cytomap('IGDCC3')('GLDN')

15q22.31

15q21.2

Type of geneprotein-codingprotein-coding
Descriptionimmunoglobulin superfamily DCC subclass member 3putative neuronal cell adhesion moleculegliomedincollomincolmedin
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000327987, ENST00000559231, 
Fusion gene scores* DoF score4 X 4 X 3=485 X 5 X 4=100
# samples 56
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(6/100*10)=-0.736965594166206
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: IGDCC3 [Title/Abstract] AND GLDN [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointIGDCC3(65667435)-GLDN(51675982), # samples:3
Anticipated loss of major functional domain due to fusion event.IGDCC3-GLDN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IGDCC3-GLDN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
IGDCC3-GLDN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
IGDCC3-GLDN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across IGDCC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across GLDN (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-DB-5277-01AIGDCC3chr15

65667435

-GLDNchr15

51675982

+
ChimerDB4LGGTCGA-DB-5277IGDCC3chr15

65667434

-GLDNchr15

51675981

+
ChimerDB4LGGTCGA-DB-5277IGDCC3chr15

65667435

-GLDNchr15

51675982

+


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Fusion Gene ORF analysis for IGDCC3-GLDN

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000327987ENST00000335449IGDCC3chr15

65667435

-GLDNchr15

51675982

+
In-frameENST00000327987ENST00000335449IGDCC3chr15

65667434

-GLDNchr15

51675981

+
In-frameENST00000327987ENST00000396399IGDCC3chr15

65667435

-GLDNchr15

51675982

+
In-frameENST00000327987ENST00000396399IGDCC3chr15

65667434

-GLDNchr15

51675981

+
intron-3CDSENST00000559231ENST00000335449IGDCC3chr15

65667435

-GLDNchr15

51675982

+
intron-3CDSENST00000559231ENST00000335449IGDCC3chr15

65667434

-GLDNchr15

51675981

+
intron-3CDSENST00000559231ENST00000396399IGDCC3chr15

65667435

-GLDNchr15

51675982

+
intron-3CDSENST00000559231ENST00000396399IGDCC3chr15

65667434

-GLDNchr15

51675981

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000327987IGDCC3chr1565667435-ENST00000335449GLDNchr1551675982+51436612371883548
ENST00000327987IGDCC3chr1565667435-ENST00000396399GLDNchr1551675982+51356612371883548
ENST00000327987IGDCC3chr1565667434-ENST00000335449GLDNchr1551675981+51436612371883548
ENST00000327987IGDCC3chr1565667434-ENST00000396399GLDNchr1551675981+51356612371883548

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000327987ENST00000335449IGDCC3chr1565667435-GLDNchr1551675982+0.0006525470.9993474
ENST00000327987ENST00000396399IGDCC3chr1565667435-GLDNchr1551675982+0.0006558440.99934417
ENST00000327987ENST00000335449IGDCC3chr1565667434-GLDNchr1551675981+0.0006525470.9993474
ENST00000327987ENST00000396399IGDCC3chr1565667434-GLDNchr1551675981+0.0006558440.99934417

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Fusion Genomic Features for IGDCC3-GLDN


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
IGDCC3chr1565667434-GLDNchr1551675981+5.32E-081
IGDCC3chr1565667434-GLDNchr1551675981+5.32E-081
IGDCC3chr1565667434-GLDNchr1551675981+5.32E-081
IGDCC3chr1565667434-GLDNchr1551675981+5.32E-081

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for IGDCC3-GLDN


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:65667435/chr15:51675982)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIGDCC3chr15:65667434chr15:51675981ENST00000327987-21436_139136815.0DomainNote=Ig-like C2-type 1
HgeneIGDCC3chr15:65667435chr15:51675982ENST00000327987-21436_139136815.0DomainNote=Ig-like C2-type 1
TgeneGLDNchr15:65667434chr15:51675981ENST00000335449210237_264144552.0Compositional biasNote=Pro-rich
TgeneGLDNchr15:65667434chr15:51675981ENST00000396399210237_26420428.0Compositional biasNote=Pro-rich
TgeneGLDNchr15:65667435chr15:51675982ENST00000335449210237_264144552.0Compositional biasNote=Pro-rich
TgeneGLDNchr15:65667435chr15:51675982ENST00000396399210237_26420428.0Compositional biasNote=Pro-rich
TgeneGLDNchr15:65667434chr15:51675981ENST00000335449210196_222144552.0DomainNote=Collagen-like 2
TgeneGLDNchr15:65667434chr15:51675981ENST00000335449210299_546144552.0DomainOlfactomedin-like
TgeneGLDNchr15:65667434chr15:51675981ENST00000396399210137_19520428.0DomainNote=Collagen-like 1
TgeneGLDNchr15:65667434chr15:51675981ENST00000396399210196_22220428.0DomainNote=Collagen-like 2
TgeneGLDNchr15:65667434chr15:51675981ENST00000396399210299_54620428.0DomainOlfactomedin-like
TgeneGLDNchr15:65667435chr15:51675982ENST00000335449210196_222144552.0DomainNote=Collagen-like 2
TgeneGLDNchr15:65667435chr15:51675982ENST00000335449210299_546144552.0DomainOlfactomedin-like
TgeneGLDNchr15:65667435chr15:51675982ENST00000396399210137_19520428.0DomainNote=Collagen-like 1
TgeneGLDNchr15:65667435chr15:51675982ENST00000396399210196_22220428.0DomainNote=Collagen-like 2
TgeneGLDNchr15:65667435chr15:51675982ENST00000396399210299_54620428.0DomainOlfactomedin-like
TgeneGLDNchr15:65667434chr15:51675981ENST0000039639921040_55120428.0Topological domainExtracellular
TgeneGLDNchr15:65667435chr15:51675982ENST0000039639921040_55120428.0Topological domainExtracellular
TgeneGLDNchr15:65667434chr15:51675981ENST0000039639921018_3920428.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneGLDNchr15:65667435chr15:51675982ENST0000039639921018_3920428.0TransmembraneHelical%3B Signal-anchor for type II membrane protein

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneIGDCC3chr15:65667434chr15:51675981ENST00000327987-214783_786136815.0Compositional biasNote=Poly-Pro
HgeneIGDCC3chr15:65667435chr15:51675982ENST00000327987-214783_786136815.0Compositional biasNote=Poly-Pro
HgeneIGDCC3chr15:65667434chr15:51675981ENST00000327987-214140_220136815.0DomainNote=Ig-like C2-type 2
HgeneIGDCC3chr15:65667434chr15:51675981ENST00000327987-214238_321136815.0DomainNote=Ig-like C2-type 3
HgeneIGDCC3chr15:65667434chr15:51675981ENST00000327987-214329_416136815.0DomainNote=Ig-like C2-type 4
HgeneIGDCC3chr15:65667434chr15:51675981ENST00000327987-214426_520136815.0DomainFibronectin type-III 1
HgeneIGDCC3chr15:65667434chr15:51675981ENST00000327987-214523_618136815.0DomainFibronectin type-III 2
HgeneIGDCC3chr15:65667435chr15:51675982ENST00000327987-214140_220136815.0DomainNote=Ig-like C2-type 2
HgeneIGDCC3chr15:65667435chr15:51675982ENST00000327987-214238_321136815.0DomainNote=Ig-like C2-type 3
HgeneIGDCC3chr15:65667435chr15:51675982ENST00000327987-214329_416136815.0DomainNote=Ig-like C2-type 4
HgeneIGDCC3chr15:65667435chr15:51675982ENST00000327987-214426_520136815.0DomainFibronectin type-III 1
HgeneIGDCC3chr15:65667435chr15:51675982ENST00000327987-214523_618136815.0DomainFibronectin type-III 2
HgeneIGDCC3chr15:65667434chr15:51675981ENST00000327987-21436_640136815.0Topological domainExtracellular
HgeneIGDCC3chr15:65667434chr15:51675981ENST00000327987-214662_814136815.0Topological domainCytoplasmic
HgeneIGDCC3chr15:65667435chr15:51675982ENST00000327987-21436_640136815.0Topological domainExtracellular
HgeneIGDCC3chr15:65667435chr15:51675982ENST00000327987-214662_814136815.0Topological domainCytoplasmic
HgeneIGDCC3chr15:65667434chr15:51675981ENST00000327987-214641_661136815.0TransmembraneHelical
HgeneIGDCC3chr15:65667435chr15:51675982ENST00000327987-214641_661136815.0TransmembraneHelical
TgeneGLDNchr15:65667434chr15:51675981ENST00000335449210137_195144552.0DomainNote=Collagen-like 1
TgeneGLDNchr15:65667435chr15:51675982ENST00000335449210137_195144552.0DomainNote=Collagen-like 1
TgeneGLDNchr15:65667434chr15:51675981ENST000003354492101_17144552.0Topological domainCytoplasmic
TgeneGLDNchr15:65667434chr15:51675981ENST0000033544921040_551144552.0Topological domainExtracellular
TgeneGLDNchr15:65667434chr15:51675981ENST000003963992101_1720428.0Topological domainCytoplasmic
TgeneGLDNchr15:65667435chr15:51675982ENST000003354492101_17144552.0Topological domainCytoplasmic
TgeneGLDNchr15:65667435chr15:51675982ENST0000033544921040_551144552.0Topological domainExtracellular
TgeneGLDNchr15:65667435chr15:51675982ENST000003963992101_1720428.0Topological domainCytoplasmic
TgeneGLDNchr15:65667434chr15:51675981ENST0000033544921018_39144552.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneGLDNchr15:65667435chr15:51675982ENST0000033544921018_39144552.0TransmembraneHelical%3B Signal-anchor for type II membrane protein


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Fusion Gene Sequence for IGDCC3-GLDN


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>38464_38464_1_IGDCC3-GLDN_IGDCC3_chr15_65667434_ENST00000327987_GLDN_chr15_51675981_ENST00000335449_length(transcript)=5143nt_BP=661nt
AGCGGTGCGAGTGTGGAGCGCGCACCCCGGGCGAGGCTGACAGATCGCCCGGGTGGGTGCAAGATGGCGCAAGCGGCGCTCCCCCTGCGC
CCCCCGCGCTGCTGAGCAGGCATGCGGCCCCAGTCCCCCACCGCCTGGGCTCGGCCCCGGCCGGAGCCCCAGCCCCGGCCCCGGCGCCGG
CCCCGCGGGACGCTGTGAGCCGCGAGAGGCCCGGGAGCCGCGCGTCGCCGAGCCGAGCTGACCGAGAGCCCCATGGCTGTGCAGCGCGCC
GCGTCTCCGCGCCGCCCGCCCGCCCCGCTCTGGCCCCGGCTCCTGCTGCCGCTGCTGTTGCTGCTGCTGCCCGCGCCGAGCGAGGGTCTT
GGCCACTCTGCTGAACTGGCATTTGCTGTGGAGCCAAGTGATGATGTTGCCGTCCCCGGGCAGCCTATAGTGCTGGACTGCAGGGTGGAG
GGGACCCCTCCAGTGCGAATCACCTGGAGGAAGAATGGGGTAGAGCTGCCAGAGAGTACCCACTCCACCTTGCTGGCCAATGGGTCCTTG
ATGATCCGTCACTTCAGGCTGGAGCCGGGAGGCAGCCCTTCGGATGAAGGTGACTATGAGTGTGTGGCCCAGAACCGCTTTGGGCTGGTG
GTCAGCCGGAAGGCTCGCATCCAAGCTGCAAGACCTCCGGGAGCCGGCGGGTTGCCAGGACACAACGGATTGGATGGACAGCCTGGTCCT
CAGGGCCCAAAAGGAGAAAAAGGAGCAAATGGAAAAAGAGGAAAAATGGGGATACCTGGAGCTGCAGGAAATCCAGGGGAAAGGGGAGAA
AAGGGAGACCATGGTGAACTGGGCCTGCAGGGAAATGAGGGCCCACCAGGGCAGAAGGGAGAAAAGGGTGACAAAGGAGATGTGTCCAAC
GACGTGCTCCTGGCAGGTGCCAAAGGTGACCAAGGCCCACCCGGTCCACCTGGGCCCCCAGGCCCTCCAGGTCCTCCAGGGCCCCCTGGA
AGCAGAAGAGCCAAAGGCCCTCGGCAGCCAAGCATGTTCAACGGCCAGTGCCCAGGTGAGACTTGTGCCATACCAAATGATGATACCTTG
GTTGGAAAAGCTGATGAGAAAGCCAGTGAACACCATTCCCCACAAGCAGAATCCATGATCACTTCCATTGGAAACCCAGTGCAAGTACTG
AAAGTGACAGAGACATTTGGGACTTGGATAAGAGAGTCTGCTAACAAGAGTGATGACCGGATTTGGGTGACAGAGCATTTTTCAGGCATC
ATGGTTAAGGAATTCAAGGATCAGCCCTCACTTCTGAATGGCAGTTACACGTTCATCCACCTTCCATACTATTTCCATGGCTGTGGGCAC
GTTGTTTACAACAACTCTCTCTACTACCACAAAGGGGGTTCTAATACCCTAGTGAGATTTGAATTTGGCCAGGAAACATCCCAAACTCTG
AAGCTTGAAAATGCCTTGTATTTTGATCGAAAATACCTTTTTGCAAATTCCAAAACTTACTTCAATCTAGCTGTAGATGAAAAGGGCCTT
TGGATTATCTATGCGTCAAGTGTGGACGGCTCGAGCATTCTTGTAGCACAACTGGATGAGAGGACATTCTCAGTGGTGCAACACGTCAAT
ACCACGTACCCTAAATCCAAGGCTGGCAACGCCTTCATTGCCCGAGGAATCCTCTATGTCACAGACACCAAAGATATGAGGGTCACATTT
GCCTTTGATTTGTTAGGAGGGAAACAGATCAATGCAAACTTTGATTTAAGAACTTCCCAGTCTGTTCTTGCCATGTTAGCATACAACATG
AGAGATCAGCATTTATATTCATGGGAAGATGGCCATTTAATGCTTTATCCTGTGCAGTTTTTGTCAACTACCTTAAATCAGTGATGTGCT
GCATTCGGCTCCCTTCAGCAAATTTCAGGGGTTTTCTGGGACCAGTTCTCCCCCAACAGGAAACTTGTTTTTTTAACGTCAGCCAGATAT
TTAGAAAATAACCTCAAAAGTGTTTATATGGTCAGTGAGCCCCGCTTAGTGAAATAGCAACAGATTGGAAGTTGAAATGGCTGAGATTTG
GTGATCTCCCCACAGCTGGCTCTGCAAGTTACCTCTTTCTCCTTGGGCCTTAGTTTCCCCATTGGTAATCTGAATTGGCTAAGATGATTG
GGGAGATTTTCTGTACCTGTAGGTAATTTGGTGATTCTTGGTGGCTGCTCTTCTCACAACTTTTATGTATCTGCTTCTGTCGTTTAGCTT
TTTTAGCCACATGCTGACCAAATTTACCTTTGAGTTGATAAGTCCAGTGGCTTGAGTAGTGAATCCCTCAGTGCTGACTTATATCTTGTT
CTTTGAAAAAATGCATTGACTCTTTAAGACATCTAAAGTATCACATTATCCATAATTTATTGCTTTTCTTTGCATCTGCACCTGCCACCA
CAGAATAACCATTACCCTCAGCTGCTGATTGGGCAGCTCTGAGATTAGCAAAAGCCAGGGACAGCTACATGTTCAGGTTTTTTTTTTTTT
TTTTTTTTCAATAAGCTATTTTTTTTCTTTTCTTATTTTAAATAGAGAGAGAGTCTTGCTATGTTTCCCAGGCTGGTCTTGAACTCCTGG
GGCTCAAGTGATCCTCCTGCCTTGGCCTCCCAAAATGCTGGATTACAGGCATGTGTGCCTGGCCCAGGTTTCTTAATAAAACAGAATCAT
GATCTTCCAGGTTCCCCCCAGTTTCTGATCATGTTGATTTGTAGCTGTGGATCATGAACACTGAATCCTCAGATCACTCTGACTTCTTAT
GCTTCTCCTGTGGATCCACTATCAAAGTACTAAATGCTGTGTAAGTAGACGTTAATCTGGCTGGAACCATGGGAAGCACTTTGCAGTGTT
CAGAAGAGAGGCTCCATTTGTGGCTATTATGTAGAACTGGGCCAGAGCCAGTCCATTGCCTGTTTTTTTAAATAAGGTTTTACTGAGCAC
AGCCACACTCATTTGTTTATGCAGTACGGCCTGACATTGCTTTTGCTCTGCAACAGCAGAGTCGAGTCATTGCAACAAAGAGCATATGGC
CCCACAGTGCCTAAAATATTGACCAGCTACCCCTTTATGGAAAAAGATTGCTGACTCCTGATAAAGAATATAAAGTGAGCCTGATTCTTG
AAAAAATCAGAACCAGAGCCTGTTTTGTTTTGTTCTAAACTAAGAAGCCGCATAGGATGTGACTTGCGTTTTGAGTAGAGGGGAAGGCTG
ATAACGGCGTAAGATGAAGTGGCCCTCCACAAAGGCTGGTTAGGGGACAGTTCTTTCTCTAACATAGTTTTAAAGGATGTGATCTGGTCC
CCTTGGATGCCAGGAGAGAATCCAGTTGAACTTGCTCCTAAATGCTCTTAAATATGCATATTTTCTGCCAACTCACTTCTTTAAACATCT
TTCAGCCCAGCGCTGCGGCCCCGGGAAGGGCCACTGCGAATAGAGAGGAAGCTGGAAAAGTTCCTGGGGCTCTGCAGCCAGGAAGGGGAA
CCAGGGCAAATCTTATGTAAAGATTTTTCAGCAACTTGTCCCAATTTGTGTGTATTCTGAAACTTTCTCTTTGGGACCAAATTCATTCTC
AATGGCCCTGAGTTCAATATATTATTAACAGCAGTATTTTAAAACTTAGGGTTGAACTGGGCATGGTGGCACATAACTGCAATCCCAGCT
ACTTTGGAGGCAGGGATGGGAGGATCACTTGAGGCCAGGATCTCAGGACCAGCCTAGAGAGATCCCATCTCTAAAAAATAAAATATAAGA
AAATAAAACTTAGGGGATATACAGATTTAAATATTCAAATCTCCCTGCTCCCCTGAAAGTCCCCAGGCAGCTGTCAATGACTTGTTTGTT
GTGTTCTCAATATGATGGCTATTTGAAACTTCACCTACTTTTCATTAGATTGGTTGTACCATGTCACCTTAGCTTTTAAAAATACTCTTT
TCAGATTCACGTTCTCTAACAAAGAGTCTCATGTTCAAGATCAATATGTCTAATAAGTGCTGGTGTCCTTTTAAAGTATTTAAATATATA
TGTTGCTGTTGCTGAATACAGGAGACCAGGTTAGGAATATAGTTTCATAATAATAGTACATACAATACTAATTGTATATAAGGTAGCAAC
CAAAAGAGGTTGTTAATTAGCACATATTCCTTTTAGAAAAATGTTTCAGAAACCTCAGTCTTGATATCTGAGCTATCTGGGCTCCCTTAC
TTGTGAGTAAGGGATCATGCTCACCACTGGAGAAGCTTACACCGGGACTTTTTTTCTTTTTTCTTTTTTTTTTGCTATGACAGAGTAATG
CTAACGTAAGGACAACTGAGTTTGATCAGTGTTTAATCGCAGTGGGTAATCTTATCTGATTGTCTTTAAAAGTGAAAAGGATTAAGATTT
TATTCTTTCTTGTAAACATTACTTGATTTTTTAAAGAAGTTTTGGGCTCACTGCTAAAATAGAGTATACAACTGAATGTTTTTAAGTCAA
GATACTGTTTTAGGAGTTTACCCTCTCATTTATAACCAAAGTTGCTCTAAAACACTTTCCAAATATCTGCACTTCTGATGTCAGAATCAA
ACCAGATAATTCTCTAATTCTTCTTTAATCTAAAGTAGATAGCTTCCCACTGGAAAGTAAACAAAACCATCCCTCCCAACCTCAAAGCTA
GGCCACACTCTATTTCAAGGCATTTTCTTTCAGCTGATAAGGTGTCCTCCTGAAGCCAAGTAGGTGGTTCTGGTCTCCAAGTATCGTTAA
GCACAGGTGCTATGACAGAAAAAGTTCTGGGGTGGAAGTTTTAAGATGAGGAGTTCTGATCTTAGGCATCTTAACAGTCACAAGGTGAAA
AGTCAAATGAAACAGTACAATTCTTGATGAGTGAGGTGTCATCTTCCAACCACACAGAGGACGTTTTGGCTATGATCATCTGATGGCAAG
TGAAGGAGAAATGAGTGATAGGGCTTTGCGTTTTCATCCAGATGCTGTGGCCCTGTGTTTCACAGCATTAAGAGCCATAATTTCCAACCT
GCACAGATCCTGAACAACAAATGAATAACGATGAATGTCTTTTTGGTTGTAATTTAACAAGTCAAATAAAATAATCATTGCTGAGCACAA
TCACATGTTGAAA

>38464_38464_1_IGDCC3-GLDN_IGDCC3_chr15_65667434_ENST00000327987_GLDN_chr15_51675981_ENST00000335449_length(amino acids)=548AA_BP=140
MTESPMAVQRAASPRRPPAPLWPRLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES
THSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAARPPGAGGLPGHNGLDGQPGPQGPKGEKGANGKRGKMGIP
GAAGNPGERGEKGDHGELGLQGNEGPPGQKGEKGDKGDVSNDVLLAGAKGDQGPPGPPGPPGPPGPPGPPGSRRAKGPRQPSMFNGQCPG
ETCAIPNDDTLVGKADEKASEHHSPQAESMITSIGNPVQVLKVTETFGTWIRESANKSDDRIWVTEHFSGIMVKEFKDQPSLLNGSYTFI
HLPYYFHGCGHVVYNNSLYYHKGGSNTLVRFEFGQETSQTLKLENALYFDRKYLFANSKTYFNLAVDEKGLWIIYASSVDGSSILVAQLD
ERTFSVVQHVNTTYPKSKAGNAFIARGILYVTDTKDMRVTFAFDLLGGKQINANFDLRTSQSVLAMLAYNMRDQHLYSWEDGHLMLYPVQ
FLSTTLNQ

--------------------------------------------------------------
>38464_38464_2_IGDCC3-GLDN_IGDCC3_chr15_65667434_ENST00000327987_GLDN_chr15_51675981_ENST00000396399_length(transcript)=5135nt_BP=661nt
AGCGGTGCGAGTGTGGAGCGCGCACCCCGGGCGAGGCTGACAGATCGCCCGGGTGGGTGCAAGATGGCGCAAGCGGCGCTCCCCCTGCGC
CCCCCGCGCTGCTGAGCAGGCATGCGGCCCCAGTCCCCCACCGCCTGGGCTCGGCCCCGGCCGGAGCCCCAGCCCCGGCCCCGGCGCCGG
CCCCGCGGGACGCTGTGAGCCGCGAGAGGCCCGGGAGCCGCGCGTCGCCGAGCCGAGCTGACCGAGAGCCCCATGGCTGTGCAGCGCGCC
GCGTCTCCGCGCCGCCCGCCCGCCCCGCTCTGGCCCCGGCTCCTGCTGCCGCTGCTGTTGCTGCTGCTGCCCGCGCCGAGCGAGGGTCTT
GGCCACTCTGCTGAACTGGCATTTGCTGTGGAGCCAAGTGATGATGTTGCCGTCCCCGGGCAGCCTATAGTGCTGGACTGCAGGGTGGAG
GGGACCCCTCCAGTGCGAATCACCTGGAGGAAGAATGGGGTAGAGCTGCCAGAGAGTACCCACTCCACCTTGCTGGCCAATGGGTCCTTG
ATGATCCGTCACTTCAGGCTGGAGCCGGGAGGCAGCCCTTCGGATGAAGGTGACTATGAGTGTGTGGCCCAGAACCGCTTTGGGCTGGTG
GTCAGCCGGAAGGCTCGCATCCAAGCTGCAAGACCTCCGGGAGCCGGCGGGTTGCCAGGACACAACGGATTGGATGGACAGCCTGGTCCT
CAGGGCCCAAAAGGAGAAAAAGGAGCAAATGGAAAAAGAGGAAAAATGGGGATACCTGGAGCTGCAGGAAATCCAGGGGAAAGGGGAGAA
AAGGGAGACCATGGTGAACTGGGCCTGCAGGGAAATGAGGGCCCACCAGGGCAGAAGGGAGAAAAGGGTGACAAAGGAGATGTGTCCAAC
GACGTGCTCCTGGCAGGTGCCAAAGGTGACCAAGGCCCACCCGGTCCACCTGGGCCCCCAGGCCCTCCAGGTCCTCCAGGGCCCCCTGGA
AGCAGAAGAGCCAAAGGCCCTCGGCAGCCAAGCATGTTCAACGGCCAGTGCCCAGGTGAGACTTGTGCCATACCAAATGATGATACCTTG
GTTGGAAAAGCTGATGAGAAAGCCAGTGAACACCATTCCCCACAAGCAGAATCCATGATCACTTCCATTGGAAACCCAGTGCAAGTACTG
AAAGTGACAGAGACATTTGGGACTTGGATAAGAGAGTCTGCTAACAAGAGTGATGACCGGATTTGGGTGACAGAGCATTTTTCAGGCATC
ATGGTTAAGGAATTCAAGGATCAGCCCTCACTTCTGAATGGCAGTTACACGTTCATCCACCTTCCATACTATTTCCATGGCTGTGGGCAC
GTTGTTTACAACAACTCTCTCTACTACCACAAAGGGGGTTCTAATACCCTAGTGAGATTTGAATTTGGCCAGGAAACATCCCAAACTCTG
AAGCTTGAAAATGCCTTGTATTTTGATCGAAAATACCTTTTTGCAAATTCCAAAACTTACTTCAATCTAGCTGTAGATGAAAAGGGCCTT
TGGATTATCTATGCGTCAAGTGTGGACGGCTCGAGCATTCTTGTAGCACAACTGGATGAGAGGACATTCTCAGTGGTGCAACACGTCAAT
ACCACGTACCCTAAATCCAAGGCTGGCAACGCCTTCATTGCCCGAGGAATCCTCTATGTCACAGACACCAAAGATATGAGGGTCACATTT
GCCTTTGATTTGTTAGGAGGGAAACAGATCAATGCAAACTTTGATTTAAGAACTTCCCAGTCTGTTCTTGCCATGTTAGCATACAACATG
AGAGATCAGCATTTATATTCATGGGAAGATGGCCATTTAATGCTTTATCCTGTGCAGTTTTTGTCAACTACCTTAAATCAGTGATGTGCT
GCATTCGGCTCCCTTCAGCAAATTTCAGGGGTTTTCTGGGACCAGTTCTCCCCCAACAGGAAACTTGTTTTTTTAACGTCAGCCAGATAT
TTAGAAAATAACCTCAAAAGTGTTTATATGGTCAGTGAGCCCCGCTTAGTGAAATAGCAACAGATTGGAAGTTGAAATGGCTGAGATTTG
GTGATCTCCCCACAGCTGGCTCTGCAAGTTACCTCTTTCTCCTTGGGCCTTAGTTTCCCCATTGGTAATCTGAATTGGCTAAGATGATTG
GGGAGATTTTCTGTACCTGTAGGTAATTTGGTGATTCTTGGTGGCTGCTCTTCTCACAACTTTTATGTATCTGCTTCTGTCGTTTAGCTT
TTTTAGCCACATGCTGACCAAATTTACCTTTGAGTTGATAAGTCCAGTGGCTTGAGTAGTGAATCCCTCAGTGCTGACTTATATCTTGTT
CTTTGAAAAAATGCATTGACTCTTTAAGACATCTAAAGTATCACATTATCCATAATTTATTGCTTTTCTTTGCATCTGCACCTGCCACCA
CAGAATAACCATTACCCTCAGCTGCTGATTGGGCAGCTCTGAGATTAGCAAAAGCCAGGGACAGCTACATGTTCAGGTTTTTTTTTTTTT
TTTTTTTTCAATAAGCTATTTTTTTTCTTTTCTTATTTTAAATAGAGAGAGAGTCTTGCTATGTTTCCCAGGCTGGTCTTGAACTCCTGG
GGCTCAAGTGATCCTCCTGCCTTGGCCTCCCAAAATGCTGGATTACAGGCATGTGTGCCTGGCCCAGGTTTCTTAATAAAACAGAATCAT
GATCTTCCAGGTTCCCCCCAGTTTCTGATCATGTTGATTTGTAGCTGTGGATCATGAACACTGAATCCTCAGATCACTCTGACTTCTTAT
GCTTCTCCTGTGGATCCACTATCAAAGTACTAAATGCTGTGTAAGTAGACGTTAATCTGGCTGGAACCATGGGAAGCACTTTGCAGTGTT
CAGAAGAGAGGCTCCATTTGTGGCTATTATGTAGAACTGGGCCAGAGCCAGTCCATTGCCTGTTTTTTTAAATAAGGTTTTACTGAGCAC
AGCCACACTCATTTGTTTATGCAGTACGGCCTGACATTGCTTTTGCTCTGCAACAGCAGAGTCGAGTCATTGCAACAAAGAGCATATGGC
CCCACAGTGCCTAAAATATTGACCAGCTACCCCTTTATGGAAAAAGATTGCTGACTCCTGATAAAGAATATAAAGTGAGCCTGATTCTTG
AAAAAATCAGAACCAGAGCCTGTTTTGTTTTGTTCTAAACTAAGAAGCCGCATAGGATGTGACTTGCGTTTTGAGTAGAGGGGAAGGCTG
ATAACGGCGTAAGATGAAGTGGCCCTCCACAAAGGCTGGTTAGGGGACAGTTCTTTCTCTAACATAGTTTTAAAGGATGTGATCTGGTCC
CCTTGGATGCCAGGAGAGAATCCAGTTGAACTTGCTCCTAAATGCTCTTAAATATGCATATTTTCTGCCAACTCACTTCTTTAAACATCT
TTCAGCCCAGCGCTGCGGCCCCGGGAAGGGCCACTGCGAATAGAGAGGAAGCTGGAAAAGTTCCTGGGGCTCTGCAGCCAGGAAGGGGAA
CCAGGGCAAATCTTATGTAAAGATTTTTCAGCAACTTGTCCCAATTTGTGTGTATTCTGAAACTTTCTCTTTGGGACCAAATTCATTCTC
AATGGCCCTGAGTTCAATATATTATTAACAGCAGTATTTTAAAACTTAGGGTTGAACTGGGCATGGTGGCACATAACTGCAATCCCAGCT
ACTTTGGAGGCAGGGATGGGAGGATCACTTGAGGCCAGGATCTCAGGACCAGCCTAGAGAGATCCCATCTCTAAAAAATAAAATATAAGA
AAATAAAACTTAGGGGATATACAGATTTAAATATTCAAATCTCCCTGCTCCCCTGAAAGTCCCCAGGCAGCTGTCAATGACTTGTTTGTT
GTGTTCTCAATATGATGGCTATTTGAAACTTCACCTACTTTTCATTAGATTGGTTGTACCATGTCACCTTAGCTTTTAAAAATACTCTTT
TCAGATTCACGTTCTCTAACAAAGAGTCTCATGTTCAAGATCAATATGTCTAATAAGTGCTGGTGTCCTTTTAAAGTATTTAAATATATA
TGTTGCTGTTGCTGAATACAGGAGACCAGGTTAGGAATATAGTTTCATAATAATAGTACATACAATACTAATTGTATATAAGGTAGCAAC
CAAAAGAGGTTGTTAATTAGCACATATTCCTTTTAGAAAAATGTTTCAGAAACCTCAGTCTTGATATCTGAGCTATCTGGGCTCCCTTAC
TTGTGAGTAAGGGATCATGCTCACCACTGGAGAAGCTTACACCGGGACTTTTTTTCTTTTTTCTTTTTTTTTTGCTATGACAGAGTAATG
CTAACGTAAGGACAACTGAGTTTGATCAGTGTTTAATCGCAGTGGGTAATCTTATCTGATTGTCTTTAAAAGTGAAAAGGATTAAGATTT
TATTCTTTCTTGTAAACATTACTTGATTTTTTAAAGAAGTTTTGGGCTCACTGCTAAAATAGAGTATACAACTGAATGTTTTTAAGTCAA
GATACTGTTTTAGGAGTTTACCCTCTCATTTATAACCAAAGTTGCTCTAAAACACTTTCCAAATATCTGCACTTCTGATGTCAGAATCAA
ACCAGATAATTCTCTAATTCTTCTTTAATCTAAAGTAGATAGCTTCCCACTGGAAAGTAAACAAAACCATCCCTCCCAACCTCAAAGCTA
GGCCACACTCTATTTCAAGGCATTTTCTTTCAGCTGATAAGGTGTCCTCCTGAAGCCAAGTAGGTGGTTCTGGTCTCCAAGTATCGTTAA
GCACAGGTGCTATGACAGAAAAAGTTCTGGGGTGGAAGTTTTAAGATGAGGAGTTCTGATCTTAGGCATCTTAACAGTCACAAGGTGAAA
AGTCAAATGAAACAGTACAATTCTTGATGAGTGAGGTGTCATCTTCCAACCACACAGAGGACGTTTTGGCTATGATCATCTGATGGCAAG
TGAAGGAGAAATGAGTGATAGGGCTTTGCGTTTTCATCCAGATGCTGTGGCCCTGTGTTTCACAGCATTAAGAGCCATAATTTCCAACCT
GCACAGATCCTGAACAACAAATGAATAACGATGAATGTCTTTTTGGTTGTAATTTAACAAGTCAAATAAAATAATCATTGCTGAGCACAA
TCACA

>38464_38464_2_IGDCC3-GLDN_IGDCC3_chr15_65667434_ENST00000327987_GLDN_chr15_51675981_ENST00000396399_length(amino acids)=548AA_BP=140
MTESPMAVQRAASPRRPPAPLWPRLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES
THSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAARPPGAGGLPGHNGLDGQPGPQGPKGEKGANGKRGKMGIP
GAAGNPGERGEKGDHGELGLQGNEGPPGQKGEKGDKGDVSNDVLLAGAKGDQGPPGPPGPPGPPGPPGPPGSRRAKGPRQPSMFNGQCPG
ETCAIPNDDTLVGKADEKASEHHSPQAESMITSIGNPVQVLKVTETFGTWIRESANKSDDRIWVTEHFSGIMVKEFKDQPSLLNGSYTFI
HLPYYFHGCGHVVYNNSLYYHKGGSNTLVRFEFGQETSQTLKLENALYFDRKYLFANSKTYFNLAVDEKGLWIIYASSVDGSSILVAQLD
ERTFSVVQHVNTTYPKSKAGNAFIARGILYVTDTKDMRVTFAFDLLGGKQINANFDLRTSQSVLAMLAYNMRDQHLYSWEDGHLMLYPVQ
FLSTTLNQ

--------------------------------------------------------------
>38464_38464_3_IGDCC3-GLDN_IGDCC3_chr15_65667435_ENST00000327987_GLDN_chr15_51675982_ENST00000335449_length(transcript)=5143nt_BP=661nt
AGCGGTGCGAGTGTGGAGCGCGCACCCCGGGCGAGGCTGACAGATCGCCCGGGTGGGTGCAAGATGGCGCAAGCGGCGCTCCCCCTGCGC
CCCCCGCGCTGCTGAGCAGGCATGCGGCCCCAGTCCCCCACCGCCTGGGCTCGGCCCCGGCCGGAGCCCCAGCCCCGGCCCCGGCGCCGG
CCCCGCGGGACGCTGTGAGCCGCGAGAGGCCCGGGAGCCGCGCGTCGCCGAGCCGAGCTGACCGAGAGCCCCATGGCTGTGCAGCGCGCC
GCGTCTCCGCGCCGCCCGCCCGCCCCGCTCTGGCCCCGGCTCCTGCTGCCGCTGCTGTTGCTGCTGCTGCCCGCGCCGAGCGAGGGTCTT
GGCCACTCTGCTGAACTGGCATTTGCTGTGGAGCCAAGTGATGATGTTGCCGTCCCCGGGCAGCCTATAGTGCTGGACTGCAGGGTGGAG
GGGACCCCTCCAGTGCGAATCACCTGGAGGAAGAATGGGGTAGAGCTGCCAGAGAGTACCCACTCCACCTTGCTGGCCAATGGGTCCTTG
ATGATCCGTCACTTCAGGCTGGAGCCGGGAGGCAGCCCTTCGGATGAAGGTGACTATGAGTGTGTGGCCCAGAACCGCTTTGGGCTGGTG
GTCAGCCGGAAGGCTCGCATCCAAGCTGCAAGACCTCCGGGAGCCGGCGGGTTGCCAGGACACAACGGATTGGATGGACAGCCTGGTCCT
CAGGGCCCAAAAGGAGAAAAAGGAGCAAATGGAAAAAGAGGAAAAATGGGGATACCTGGAGCTGCAGGAAATCCAGGGGAAAGGGGAGAA
AAGGGAGACCATGGTGAACTGGGCCTGCAGGGAAATGAGGGCCCACCAGGGCAGAAGGGAGAAAAGGGTGACAAAGGAGATGTGTCCAAC
GACGTGCTCCTGGCAGGTGCCAAAGGTGACCAAGGCCCACCCGGTCCACCTGGGCCCCCAGGCCCTCCAGGTCCTCCAGGGCCCCCTGGA
AGCAGAAGAGCCAAAGGCCCTCGGCAGCCAAGCATGTTCAACGGCCAGTGCCCAGGTGAGACTTGTGCCATACCAAATGATGATACCTTG
GTTGGAAAAGCTGATGAGAAAGCCAGTGAACACCATTCCCCACAAGCAGAATCCATGATCACTTCCATTGGAAACCCAGTGCAAGTACTG
AAAGTGACAGAGACATTTGGGACTTGGATAAGAGAGTCTGCTAACAAGAGTGATGACCGGATTTGGGTGACAGAGCATTTTTCAGGCATC
ATGGTTAAGGAATTCAAGGATCAGCCCTCACTTCTGAATGGCAGTTACACGTTCATCCACCTTCCATACTATTTCCATGGCTGTGGGCAC
GTTGTTTACAACAACTCTCTCTACTACCACAAAGGGGGTTCTAATACCCTAGTGAGATTTGAATTTGGCCAGGAAACATCCCAAACTCTG
AAGCTTGAAAATGCCTTGTATTTTGATCGAAAATACCTTTTTGCAAATTCCAAAACTTACTTCAATCTAGCTGTAGATGAAAAGGGCCTT
TGGATTATCTATGCGTCAAGTGTGGACGGCTCGAGCATTCTTGTAGCACAACTGGATGAGAGGACATTCTCAGTGGTGCAACACGTCAAT
ACCACGTACCCTAAATCCAAGGCTGGCAACGCCTTCATTGCCCGAGGAATCCTCTATGTCACAGACACCAAAGATATGAGGGTCACATTT
GCCTTTGATTTGTTAGGAGGGAAACAGATCAATGCAAACTTTGATTTAAGAACTTCCCAGTCTGTTCTTGCCATGTTAGCATACAACATG
AGAGATCAGCATTTATATTCATGGGAAGATGGCCATTTAATGCTTTATCCTGTGCAGTTTTTGTCAACTACCTTAAATCAGTGATGTGCT
GCATTCGGCTCCCTTCAGCAAATTTCAGGGGTTTTCTGGGACCAGTTCTCCCCCAACAGGAAACTTGTTTTTTTAACGTCAGCCAGATAT
TTAGAAAATAACCTCAAAAGTGTTTATATGGTCAGTGAGCCCCGCTTAGTGAAATAGCAACAGATTGGAAGTTGAAATGGCTGAGATTTG
GTGATCTCCCCACAGCTGGCTCTGCAAGTTACCTCTTTCTCCTTGGGCCTTAGTTTCCCCATTGGTAATCTGAATTGGCTAAGATGATTG
GGGAGATTTTCTGTACCTGTAGGTAATTTGGTGATTCTTGGTGGCTGCTCTTCTCACAACTTTTATGTATCTGCTTCTGTCGTTTAGCTT
TTTTAGCCACATGCTGACCAAATTTACCTTTGAGTTGATAAGTCCAGTGGCTTGAGTAGTGAATCCCTCAGTGCTGACTTATATCTTGTT
CTTTGAAAAAATGCATTGACTCTTTAAGACATCTAAAGTATCACATTATCCATAATTTATTGCTTTTCTTTGCATCTGCACCTGCCACCA
CAGAATAACCATTACCCTCAGCTGCTGATTGGGCAGCTCTGAGATTAGCAAAAGCCAGGGACAGCTACATGTTCAGGTTTTTTTTTTTTT
TTTTTTTTCAATAAGCTATTTTTTTTCTTTTCTTATTTTAAATAGAGAGAGAGTCTTGCTATGTTTCCCAGGCTGGTCTTGAACTCCTGG
GGCTCAAGTGATCCTCCTGCCTTGGCCTCCCAAAATGCTGGATTACAGGCATGTGTGCCTGGCCCAGGTTTCTTAATAAAACAGAATCAT
GATCTTCCAGGTTCCCCCCAGTTTCTGATCATGTTGATTTGTAGCTGTGGATCATGAACACTGAATCCTCAGATCACTCTGACTTCTTAT
GCTTCTCCTGTGGATCCACTATCAAAGTACTAAATGCTGTGTAAGTAGACGTTAATCTGGCTGGAACCATGGGAAGCACTTTGCAGTGTT
CAGAAGAGAGGCTCCATTTGTGGCTATTATGTAGAACTGGGCCAGAGCCAGTCCATTGCCTGTTTTTTTAAATAAGGTTTTACTGAGCAC
AGCCACACTCATTTGTTTATGCAGTACGGCCTGACATTGCTTTTGCTCTGCAACAGCAGAGTCGAGTCATTGCAACAAAGAGCATATGGC
CCCACAGTGCCTAAAATATTGACCAGCTACCCCTTTATGGAAAAAGATTGCTGACTCCTGATAAAGAATATAAAGTGAGCCTGATTCTTG
AAAAAATCAGAACCAGAGCCTGTTTTGTTTTGTTCTAAACTAAGAAGCCGCATAGGATGTGACTTGCGTTTTGAGTAGAGGGGAAGGCTG
ATAACGGCGTAAGATGAAGTGGCCCTCCACAAAGGCTGGTTAGGGGACAGTTCTTTCTCTAACATAGTTTTAAAGGATGTGATCTGGTCC
CCTTGGATGCCAGGAGAGAATCCAGTTGAACTTGCTCCTAAATGCTCTTAAATATGCATATTTTCTGCCAACTCACTTCTTTAAACATCT
TTCAGCCCAGCGCTGCGGCCCCGGGAAGGGCCACTGCGAATAGAGAGGAAGCTGGAAAAGTTCCTGGGGCTCTGCAGCCAGGAAGGGGAA
CCAGGGCAAATCTTATGTAAAGATTTTTCAGCAACTTGTCCCAATTTGTGTGTATTCTGAAACTTTCTCTTTGGGACCAAATTCATTCTC
AATGGCCCTGAGTTCAATATATTATTAACAGCAGTATTTTAAAACTTAGGGTTGAACTGGGCATGGTGGCACATAACTGCAATCCCAGCT
ACTTTGGAGGCAGGGATGGGAGGATCACTTGAGGCCAGGATCTCAGGACCAGCCTAGAGAGATCCCATCTCTAAAAAATAAAATATAAGA
AAATAAAACTTAGGGGATATACAGATTTAAATATTCAAATCTCCCTGCTCCCCTGAAAGTCCCCAGGCAGCTGTCAATGACTTGTTTGTT
GTGTTCTCAATATGATGGCTATTTGAAACTTCACCTACTTTTCATTAGATTGGTTGTACCATGTCACCTTAGCTTTTAAAAATACTCTTT
TCAGATTCACGTTCTCTAACAAAGAGTCTCATGTTCAAGATCAATATGTCTAATAAGTGCTGGTGTCCTTTTAAAGTATTTAAATATATA
TGTTGCTGTTGCTGAATACAGGAGACCAGGTTAGGAATATAGTTTCATAATAATAGTACATACAATACTAATTGTATATAAGGTAGCAAC
CAAAAGAGGTTGTTAATTAGCACATATTCCTTTTAGAAAAATGTTTCAGAAACCTCAGTCTTGATATCTGAGCTATCTGGGCTCCCTTAC
TTGTGAGTAAGGGATCATGCTCACCACTGGAGAAGCTTACACCGGGACTTTTTTTCTTTTTTCTTTTTTTTTTGCTATGACAGAGTAATG
CTAACGTAAGGACAACTGAGTTTGATCAGTGTTTAATCGCAGTGGGTAATCTTATCTGATTGTCTTTAAAAGTGAAAAGGATTAAGATTT
TATTCTTTCTTGTAAACATTACTTGATTTTTTAAAGAAGTTTTGGGCTCACTGCTAAAATAGAGTATACAACTGAATGTTTTTAAGTCAA
GATACTGTTTTAGGAGTTTACCCTCTCATTTATAACCAAAGTTGCTCTAAAACACTTTCCAAATATCTGCACTTCTGATGTCAGAATCAA
ACCAGATAATTCTCTAATTCTTCTTTAATCTAAAGTAGATAGCTTCCCACTGGAAAGTAAACAAAACCATCCCTCCCAACCTCAAAGCTA
GGCCACACTCTATTTCAAGGCATTTTCTTTCAGCTGATAAGGTGTCCTCCTGAAGCCAAGTAGGTGGTTCTGGTCTCCAAGTATCGTTAA
GCACAGGTGCTATGACAGAAAAAGTTCTGGGGTGGAAGTTTTAAGATGAGGAGTTCTGATCTTAGGCATCTTAACAGTCACAAGGTGAAA
AGTCAAATGAAACAGTACAATTCTTGATGAGTGAGGTGTCATCTTCCAACCACACAGAGGACGTTTTGGCTATGATCATCTGATGGCAAG
TGAAGGAGAAATGAGTGATAGGGCTTTGCGTTTTCATCCAGATGCTGTGGCCCTGTGTTTCACAGCATTAAGAGCCATAATTTCCAACCT
GCACAGATCCTGAACAACAAATGAATAACGATGAATGTCTTTTTGGTTGTAATTTAACAAGTCAAATAAAATAATCATTGCTGAGCACAA
TCACATGTTGAAA

>38464_38464_3_IGDCC3-GLDN_IGDCC3_chr15_65667435_ENST00000327987_GLDN_chr15_51675982_ENST00000335449_length(amino acids)=548AA_BP=140
MTESPMAVQRAASPRRPPAPLWPRLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES
THSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAARPPGAGGLPGHNGLDGQPGPQGPKGEKGANGKRGKMGIP
GAAGNPGERGEKGDHGELGLQGNEGPPGQKGEKGDKGDVSNDVLLAGAKGDQGPPGPPGPPGPPGPPGPPGSRRAKGPRQPSMFNGQCPG
ETCAIPNDDTLVGKADEKASEHHSPQAESMITSIGNPVQVLKVTETFGTWIRESANKSDDRIWVTEHFSGIMVKEFKDQPSLLNGSYTFI
HLPYYFHGCGHVVYNNSLYYHKGGSNTLVRFEFGQETSQTLKLENALYFDRKYLFANSKTYFNLAVDEKGLWIIYASSVDGSSILVAQLD
ERTFSVVQHVNTTYPKSKAGNAFIARGILYVTDTKDMRVTFAFDLLGGKQINANFDLRTSQSVLAMLAYNMRDQHLYSWEDGHLMLYPVQ
FLSTTLNQ

--------------------------------------------------------------
>38464_38464_4_IGDCC3-GLDN_IGDCC3_chr15_65667435_ENST00000327987_GLDN_chr15_51675982_ENST00000396399_length(transcript)=5135nt_BP=661nt
AGCGGTGCGAGTGTGGAGCGCGCACCCCGGGCGAGGCTGACAGATCGCCCGGGTGGGTGCAAGATGGCGCAAGCGGCGCTCCCCCTGCGC
CCCCCGCGCTGCTGAGCAGGCATGCGGCCCCAGTCCCCCACCGCCTGGGCTCGGCCCCGGCCGGAGCCCCAGCCCCGGCCCCGGCGCCGG
CCCCGCGGGACGCTGTGAGCCGCGAGAGGCCCGGGAGCCGCGCGTCGCCGAGCCGAGCTGACCGAGAGCCCCATGGCTGTGCAGCGCGCC
GCGTCTCCGCGCCGCCCGCCCGCCCCGCTCTGGCCCCGGCTCCTGCTGCCGCTGCTGTTGCTGCTGCTGCCCGCGCCGAGCGAGGGTCTT
GGCCACTCTGCTGAACTGGCATTTGCTGTGGAGCCAAGTGATGATGTTGCCGTCCCCGGGCAGCCTATAGTGCTGGACTGCAGGGTGGAG
GGGACCCCTCCAGTGCGAATCACCTGGAGGAAGAATGGGGTAGAGCTGCCAGAGAGTACCCACTCCACCTTGCTGGCCAATGGGTCCTTG
ATGATCCGTCACTTCAGGCTGGAGCCGGGAGGCAGCCCTTCGGATGAAGGTGACTATGAGTGTGTGGCCCAGAACCGCTTTGGGCTGGTG
GTCAGCCGGAAGGCTCGCATCCAAGCTGCAAGACCTCCGGGAGCCGGCGGGTTGCCAGGACACAACGGATTGGATGGACAGCCTGGTCCT
CAGGGCCCAAAAGGAGAAAAAGGAGCAAATGGAAAAAGAGGAAAAATGGGGATACCTGGAGCTGCAGGAAATCCAGGGGAAAGGGGAGAA
AAGGGAGACCATGGTGAACTGGGCCTGCAGGGAAATGAGGGCCCACCAGGGCAGAAGGGAGAAAAGGGTGACAAAGGAGATGTGTCCAAC
GACGTGCTCCTGGCAGGTGCCAAAGGTGACCAAGGCCCACCCGGTCCACCTGGGCCCCCAGGCCCTCCAGGTCCTCCAGGGCCCCCTGGA
AGCAGAAGAGCCAAAGGCCCTCGGCAGCCAAGCATGTTCAACGGCCAGTGCCCAGGTGAGACTTGTGCCATACCAAATGATGATACCTTG
GTTGGAAAAGCTGATGAGAAAGCCAGTGAACACCATTCCCCACAAGCAGAATCCATGATCACTTCCATTGGAAACCCAGTGCAAGTACTG
AAAGTGACAGAGACATTTGGGACTTGGATAAGAGAGTCTGCTAACAAGAGTGATGACCGGATTTGGGTGACAGAGCATTTTTCAGGCATC
ATGGTTAAGGAATTCAAGGATCAGCCCTCACTTCTGAATGGCAGTTACACGTTCATCCACCTTCCATACTATTTCCATGGCTGTGGGCAC
GTTGTTTACAACAACTCTCTCTACTACCACAAAGGGGGTTCTAATACCCTAGTGAGATTTGAATTTGGCCAGGAAACATCCCAAACTCTG
AAGCTTGAAAATGCCTTGTATTTTGATCGAAAATACCTTTTTGCAAATTCCAAAACTTACTTCAATCTAGCTGTAGATGAAAAGGGCCTT
TGGATTATCTATGCGTCAAGTGTGGACGGCTCGAGCATTCTTGTAGCACAACTGGATGAGAGGACATTCTCAGTGGTGCAACACGTCAAT
ACCACGTACCCTAAATCCAAGGCTGGCAACGCCTTCATTGCCCGAGGAATCCTCTATGTCACAGACACCAAAGATATGAGGGTCACATTT
GCCTTTGATTTGTTAGGAGGGAAACAGATCAATGCAAACTTTGATTTAAGAACTTCCCAGTCTGTTCTTGCCATGTTAGCATACAACATG
AGAGATCAGCATTTATATTCATGGGAAGATGGCCATTTAATGCTTTATCCTGTGCAGTTTTTGTCAACTACCTTAAATCAGTGATGTGCT
GCATTCGGCTCCCTTCAGCAAATTTCAGGGGTTTTCTGGGACCAGTTCTCCCCCAACAGGAAACTTGTTTTTTTAACGTCAGCCAGATAT
TTAGAAAATAACCTCAAAAGTGTTTATATGGTCAGTGAGCCCCGCTTAGTGAAATAGCAACAGATTGGAAGTTGAAATGGCTGAGATTTG
GTGATCTCCCCACAGCTGGCTCTGCAAGTTACCTCTTTCTCCTTGGGCCTTAGTTTCCCCATTGGTAATCTGAATTGGCTAAGATGATTG
GGGAGATTTTCTGTACCTGTAGGTAATTTGGTGATTCTTGGTGGCTGCTCTTCTCACAACTTTTATGTATCTGCTTCTGTCGTTTAGCTT
TTTTAGCCACATGCTGACCAAATTTACCTTTGAGTTGATAAGTCCAGTGGCTTGAGTAGTGAATCCCTCAGTGCTGACTTATATCTTGTT
CTTTGAAAAAATGCATTGACTCTTTAAGACATCTAAAGTATCACATTATCCATAATTTATTGCTTTTCTTTGCATCTGCACCTGCCACCA
CAGAATAACCATTACCCTCAGCTGCTGATTGGGCAGCTCTGAGATTAGCAAAAGCCAGGGACAGCTACATGTTCAGGTTTTTTTTTTTTT
TTTTTTTTCAATAAGCTATTTTTTTTCTTTTCTTATTTTAAATAGAGAGAGAGTCTTGCTATGTTTCCCAGGCTGGTCTTGAACTCCTGG
GGCTCAAGTGATCCTCCTGCCTTGGCCTCCCAAAATGCTGGATTACAGGCATGTGTGCCTGGCCCAGGTTTCTTAATAAAACAGAATCAT
GATCTTCCAGGTTCCCCCCAGTTTCTGATCATGTTGATTTGTAGCTGTGGATCATGAACACTGAATCCTCAGATCACTCTGACTTCTTAT
GCTTCTCCTGTGGATCCACTATCAAAGTACTAAATGCTGTGTAAGTAGACGTTAATCTGGCTGGAACCATGGGAAGCACTTTGCAGTGTT
CAGAAGAGAGGCTCCATTTGTGGCTATTATGTAGAACTGGGCCAGAGCCAGTCCATTGCCTGTTTTTTTAAATAAGGTTTTACTGAGCAC
AGCCACACTCATTTGTTTATGCAGTACGGCCTGACATTGCTTTTGCTCTGCAACAGCAGAGTCGAGTCATTGCAACAAAGAGCATATGGC
CCCACAGTGCCTAAAATATTGACCAGCTACCCCTTTATGGAAAAAGATTGCTGACTCCTGATAAAGAATATAAAGTGAGCCTGATTCTTG
AAAAAATCAGAACCAGAGCCTGTTTTGTTTTGTTCTAAACTAAGAAGCCGCATAGGATGTGACTTGCGTTTTGAGTAGAGGGGAAGGCTG
ATAACGGCGTAAGATGAAGTGGCCCTCCACAAAGGCTGGTTAGGGGACAGTTCTTTCTCTAACATAGTTTTAAAGGATGTGATCTGGTCC
CCTTGGATGCCAGGAGAGAATCCAGTTGAACTTGCTCCTAAATGCTCTTAAATATGCATATTTTCTGCCAACTCACTTCTTTAAACATCT
TTCAGCCCAGCGCTGCGGCCCCGGGAAGGGCCACTGCGAATAGAGAGGAAGCTGGAAAAGTTCCTGGGGCTCTGCAGCCAGGAAGGGGAA
CCAGGGCAAATCTTATGTAAAGATTTTTCAGCAACTTGTCCCAATTTGTGTGTATTCTGAAACTTTCTCTTTGGGACCAAATTCATTCTC
AATGGCCCTGAGTTCAATATATTATTAACAGCAGTATTTTAAAACTTAGGGTTGAACTGGGCATGGTGGCACATAACTGCAATCCCAGCT
ACTTTGGAGGCAGGGATGGGAGGATCACTTGAGGCCAGGATCTCAGGACCAGCCTAGAGAGATCCCATCTCTAAAAAATAAAATATAAGA
AAATAAAACTTAGGGGATATACAGATTTAAATATTCAAATCTCCCTGCTCCCCTGAAAGTCCCCAGGCAGCTGTCAATGACTTGTTTGTT
GTGTTCTCAATATGATGGCTATTTGAAACTTCACCTACTTTTCATTAGATTGGTTGTACCATGTCACCTTAGCTTTTAAAAATACTCTTT
TCAGATTCACGTTCTCTAACAAAGAGTCTCATGTTCAAGATCAATATGTCTAATAAGTGCTGGTGTCCTTTTAAAGTATTTAAATATATA
TGTTGCTGTTGCTGAATACAGGAGACCAGGTTAGGAATATAGTTTCATAATAATAGTACATACAATACTAATTGTATATAAGGTAGCAAC
CAAAAGAGGTTGTTAATTAGCACATATTCCTTTTAGAAAAATGTTTCAGAAACCTCAGTCTTGATATCTGAGCTATCTGGGCTCCCTTAC
TTGTGAGTAAGGGATCATGCTCACCACTGGAGAAGCTTACACCGGGACTTTTTTTCTTTTTTCTTTTTTTTTTGCTATGACAGAGTAATG
CTAACGTAAGGACAACTGAGTTTGATCAGTGTTTAATCGCAGTGGGTAATCTTATCTGATTGTCTTTAAAAGTGAAAAGGATTAAGATTT
TATTCTTTCTTGTAAACATTACTTGATTTTTTAAAGAAGTTTTGGGCTCACTGCTAAAATAGAGTATACAACTGAATGTTTTTAAGTCAA
GATACTGTTTTAGGAGTTTACCCTCTCATTTATAACCAAAGTTGCTCTAAAACACTTTCCAAATATCTGCACTTCTGATGTCAGAATCAA
ACCAGATAATTCTCTAATTCTTCTTTAATCTAAAGTAGATAGCTTCCCACTGGAAAGTAAACAAAACCATCCCTCCCAACCTCAAAGCTA
GGCCACACTCTATTTCAAGGCATTTTCTTTCAGCTGATAAGGTGTCCTCCTGAAGCCAAGTAGGTGGTTCTGGTCTCCAAGTATCGTTAA
GCACAGGTGCTATGACAGAAAAAGTTCTGGGGTGGAAGTTTTAAGATGAGGAGTTCTGATCTTAGGCATCTTAACAGTCACAAGGTGAAA
AGTCAAATGAAACAGTACAATTCTTGATGAGTGAGGTGTCATCTTCCAACCACACAGAGGACGTTTTGGCTATGATCATCTGATGGCAAG
TGAAGGAGAAATGAGTGATAGGGCTTTGCGTTTTCATCCAGATGCTGTGGCCCTGTGTTTCACAGCATTAAGAGCCATAATTTCCAACCT
GCACAGATCCTGAACAACAAATGAATAACGATGAATGTCTTTTTGGTTGTAATTTAACAAGTCAAATAAAATAATCATTGCTGAGCACAA
TCACA

>38464_38464_4_IGDCC3-GLDN_IGDCC3_chr15_65667435_ENST00000327987_GLDN_chr15_51675982_ENST00000396399_length(amino acids)=548AA_BP=140
MTESPMAVQRAASPRRPPAPLWPRLLLPLLLLLLPAPSEGLGHSAELAFAVEPSDDVAVPGQPIVLDCRVEGTPPVRITWRKNGVELPES
THSTLLANGSLMIRHFRLEPGGSPSDEGDYECVAQNRFGLVVSRKARIQAARPPGAGGLPGHNGLDGQPGPQGPKGEKGANGKRGKMGIP
GAAGNPGERGEKGDHGELGLQGNEGPPGQKGEKGDKGDVSNDVLLAGAKGDQGPPGPPGPPGPPGPPGPPGSRRAKGPRQPSMFNGQCPG
ETCAIPNDDTLVGKADEKASEHHSPQAESMITSIGNPVQVLKVTETFGTWIRESANKSDDRIWVTEHFSGIMVKEFKDQPSLLNGSYTFI
HLPYYFHGCGHVVYNNSLYYHKGGSNTLVRFEFGQETSQTLKLENALYFDRKYLFANSKTYFNLAVDEKGLWIIYASSVDGSSILVAQLD
ERTFSVVQHVNTTYPKSKAGNAFIARGILYVTDTKDMRVTFAFDLLGGKQINANFDLRTSQSVLAMLAYNMRDQHLYSWEDGHLMLYPVQ
FLSTTLNQ

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Fusion Gene PPI Analysis for IGDCC3-GLDN


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for IGDCC3-GLDN


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for IGDCC3-GLDN


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC4310670LETHAL CONGENITAL CONTRACTURE SYNDROME 111CTD_human;GENOMICS_ENGLAND;UNIPROT