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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CD40-LAMC3 (FusionGDB2 ID:HG958TG10319)

Fusion Gene Summary for CD40-LAMC3

check button Fusion gene summary
Fusion gene informationFusion gene name: CD40-LAMC3
Fusion gene ID: hg958tg10319
HgeneTgene
Gene symbol

CD40

LAMC3

Gene ID

958

10319

Gene nameCD40 moleculelaminin subunit gamma 3
SynonymsBp50|CDW40|TNFRSF5|p50OCCM
Cytomap('CD40')('LAMC3')

20q13.12

9q34.12

Type of geneprotein-codingprotein-coding
Descriptiontumor necrosis factor receptor superfamily member 5B cell surface antigen CD40B cell-associated moleculeCD40 molecule, TNF receptor superfamily member 5CD40L receptorlaminin subunit gamma-3laminin, gamma 3laminin-12 subunit gammalaminin-14 subunit gammalaminin-15 subunit gamma
Modification date2020032720200313
UniProtAcc.

Q9Y6N6

Ensembl transtripts involved in fusion geneENST00000489304, ENST00000372276, 
ENST00000372285, 
Fusion gene scores* DoF score2 X 2 X 2=86 X 6 X 5=180
# samples 26
** MAII scorelog2(2/8*10)=1.32192809488736log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CD40 [Title/Abstract] AND LAMC3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCD40(44751395)-LAMC3(133901672), # samples:1
Anticipated loss of major functional domain due to fusion event.CD40-LAMC3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CD40-LAMC3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CD40-LAMC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CD40-LAMC3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD40

GO:0023035

CD40 signaling pathway

31331973

HgeneCD40

GO:2000353

positive regulation of endothelial cell apoptotic process

12885753


check buttonFusion gene breakpoints across CD40 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across LAMC3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4GBMTCGA-28-5215-01ACD40chr20

44751395

+LAMC3chr9

133901672

+


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Fusion Gene ORF analysis for CD40-LAMC3

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000489304ENST00000361069CD40chr20

44751395

+LAMC3chr9

133901672

+
3UTR-3UTRENST00000489304ENST00000480883CD40chr20

44751395

+LAMC3chr9

133901672

+
5CDS-3UTRENST00000372276ENST00000480883CD40chr20

44751395

+LAMC3chr9

133901672

+
5CDS-3UTRENST00000372285ENST00000480883CD40chr20

44751395

+LAMC3chr9

133901672

+
In-frameENST00000372276ENST00000361069CD40chr20

44751395

+LAMC3chr9

133901672

+
In-frameENST00000372285ENST00000361069CD40chr20

44751395

+LAMC3chr9

133901672

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000372285CD40chr2044751395+ENST00000361069LAMC3chr9133901672+61024757248291585
ENST00000372276CD40chr2044751395+ENST00000361069LAMC3chr9133901672+60584312847851585

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000372285ENST00000361069CD40chr2044751395+LAMC3chr9133901672+0.0079962050.99200374
ENST00000372276ENST00000361069CD40chr2044751395+LAMC3chr9133901672+0.0075827980.9924172

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Fusion Genomic Features for CD40-LAMC3


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CD40chr2044751395+LAMC3chr9133901671+4.63E-050.99995375
CD40chr2044751395+LAMC3chr9133901671+4.63E-050.99995375

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CD40-LAMC3


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr20:44751395/chr9:133901672)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.LAMC3

Q9Y6N6

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Binding to cells via a high affinity receptor, laminin is thought to mediate the attachment, migration and organization of cells into tissues during embryonic development by interacting with other extracellular matrix components.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD40chr20:44751395chr9:133901672ENST00000372276+4825_60134505.0RepeatNote=TNFR-Cys 1
HgeneCD40chr20:44751395chr9:133901672ENST00000372276+4861_103134505.0RepeatNote=TNFR-Cys 2
HgeneCD40chr20:44751395chr9:133901672ENST00000372285+4925_60134278.0RepeatNote=TNFR-Cys 1
HgeneCD40chr20:44751395chr9:133901672ENST00000372285+4961_103134278.0RepeatNote=TNFR-Cys 2
TgeneLAMC3chr20:44751395chr9:133901672ENST000003610690281073_11341241576.0Coiled coilOntology_term=ECO:0000255
TgeneLAMC3chr20:44751395chr9:133901672ENST000003610690281201_12281241576.0Coiled coilOntology_term=ECO:0000255
TgeneLAMC3chr20:44751395chr9:133901672ENST000003610690281410_14921241576.0Coiled coilOntology_term=ECO:0000255
TgeneLAMC3chr20:44751395chr9:133901672ENST000003610690281523_15671241576.0Coiled coilOntology_term=ECO:0000255
TgeneLAMC3chr20:44751395chr9:133901672ENST00000361069028271_3261241576.0DomainLaminin EGF-like 1
TgeneLAMC3chr20:44751395chr9:133901672ENST00000361069028327_3821241576.0DomainLaminin EGF-like 2
TgeneLAMC3chr20:44751395chr9:133901672ENST00000361069028383_4291241576.0DomainLaminin EGF-like 3
TgeneLAMC3chr20:44751395chr9:133901672ENST00000361069028430_4791241576.0DomainLaminin EGF-like 4
TgeneLAMC3chr20:44751395chr9:133901672ENST00000361069028480_4891241576.0DomainLaminin EGF-like 5%3B first part
TgeneLAMC3chr20:44751395chr9:133901672ENST00000361069028499_6721241576.0DomainLaminin IV type A
TgeneLAMC3chr20:44751395chr9:133901672ENST00000361069028673_7061241576.0DomainLaminin EGF-like 5%3B second part
TgeneLAMC3chr20:44751395chr9:133901672ENST00000361069028707_7541241576.0DomainLaminin EGF-like 6
TgeneLAMC3chr20:44751395chr9:133901672ENST00000361069028755_8091241576.0DomainLaminin EGF-like 7
TgeneLAMC3chr20:44751395chr9:133901672ENST00000361069028810_8651241576.0DomainLaminin EGF-like 8
TgeneLAMC3chr20:44751395chr9:133901672ENST00000361069028866_9161241576.0DomainLaminin EGF-like 9
TgeneLAMC3chr20:44751395chr9:133901672ENST00000361069028917_9641241576.0DomainLaminin EGF-like 10
TgeneLAMC3chr20:44751395chr9:133901672ENST00000361069028965_10131241576.0DomainLaminin EGF-like 11
TgeneLAMC3chr20:44751395chr9:133901672ENST000003610690281059_10611241576.0MotifCell attachment site
TgeneLAMC3chr20:44751395chr9:133901672ENST000003610690281014_15751241576.0RegionNote=Domain II and I

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD40chr20:44751395chr9:133901672ENST00000372276+48104_144134505.0RepeatNote=TNFR-Cys 3
HgeneCD40chr20:44751395chr9:133901672ENST00000372276+48145_187134505.0RepeatNote=TNFR-Cys 4
HgeneCD40chr20:44751395chr9:133901672ENST00000372285+49104_144134278.0RepeatNote=TNFR-Cys 3
HgeneCD40chr20:44751395chr9:133901672ENST00000372285+49145_187134278.0RepeatNote=TNFR-Cys 4
HgeneCD40chr20:44751395chr9:133901672ENST00000372276+48216_277134505.0Topological domainCytoplasmic
HgeneCD40chr20:44751395chr9:133901672ENST00000372276+4821_193134505.0Topological domainExtracellular
HgeneCD40chr20:44751395chr9:133901672ENST00000372285+49216_277134278.0Topological domainCytoplasmic
HgeneCD40chr20:44751395chr9:133901672ENST00000372285+4921_193134278.0Topological domainExtracellular
HgeneCD40chr20:44751395chr9:133901672ENST00000372276+48194_215134505.0TransmembraneHelical
HgeneCD40chr20:44751395chr9:133901672ENST00000372285+49194_215134278.0TransmembraneHelical
TgeneLAMC3chr20:44751395chr9:133901672ENST0000036106902831_2701241576.0DomainLaminin N-terminal


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Fusion Gene Sequence for CD40-LAMC3


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>14501_14501_1_CD40-LAMC3_CD40_chr20_44751395_ENST00000372276_LAMC3_chr9_133901672_ENST00000361069_length(transcript)=6058nt_BP=431nt
TGGTCCTGCCGCCTGGTCTCACCTCGCTATGGTTCGTCTGCCTCTGCAGTGCGTCCTCTGGGGCTGCTTGCTGACCGCTGTCCATCCAGA
ACCACCCACTGCATGCAGAGAAAAACAGTACCTAATAAACAGTCAGTGCTGTTCTTTGTGCCAGCCAGGACAGAAACTGGTGAGTGACTG
CACAGAGTTCACTGAAACGGAATGCCTTCCTTGCGGTGAAAGCGAATTCCTAGACACCTGGAACAGAGAGACACACTGCCACCAGCACAA
ATACTGCGACCCCAACCTAGGGCTTCGGGTCCAGCAGAAGGGCACCTCAGAAACAGACACCATCTGCACCTGTGAAGAAGGCTGGCACTG
TACGAGTGAGGCCTGTGAGAGCTGTGTCCTGCACCGCTCATGCTCGCCCGGCTTTGGGGTCAAGCAGATTGGGAAGGCTTATGAGATCAC
GTATGTGAGGCTGAAGTTCCACACCAGTCGCCCTGAGAGCTTTGCCATCTACAAGCGCAGCCGCGCCGACGGCCCATGGGAGCCCTACCA
GTTCTACAGCGCCTCCTGCCAGAAGACCTACGGCCGGCCCGAGGGCCAGTACCTGCGCCCCGGCGAGGACGAGCGCGTGGCCTTCTGCAC
CTCTGAGTTCAGCGACATCTCCCCGCTGAGTGGCGGCAACGTGGCCTTCTCCACCCTGGAGGGCCGGCCCAGCGCCTACAACTTCGAGGA
GAGCCCTGGGCTGCAGGAGTGGGTCACCAGCACCGAACTCCTCATCTCTCTAGACCGGCTCAACACGTTTGGGGACGACATCTTCAAGGA
CCCCAAGGTGCTCCAGTCCTACTATTATGCCGTGTCCGACTTCTCTGTGGGCGGCAGGTGCAAGTGCAACGGGCATGCCAGCGAGTGCGG
CCCCGACGTGGCAGGCCAGTTGGCCTGCCGGTGCCAGCACAACACCACCGGCACAGACTGTGAGCGCTGCCTGCCCTTCTTCCAGGACCG
CCCGTGGGCCCGGGGCACCGCCGAGGCTGCCCACGAGTGTCTGCCCTGCAACTGCAGTGGCCGCTCCGAGGAATGCACGTTTGATCGGGA
GCTCTTCCGCAGCACAGGCCACGGCGGGCGCTGTCACCACTGCCGTGACCACACAGCTGGGCCACACTGTGAGCGCTGTCAGGAGAATTT
CTATCACTGGGACCCGCGGATGCCATGCCAGCCCTGTGACTGCCAGTCGGCAGGCTCCCTACACCTCCAGTGCGATGACACAGGCACCTG
CGCCTGCAAGCCCACGGTGACTGGCTGGAAGTGTGACCGCTGTCTGCCCGGGTTCCACTCGCTCAGTGAGGGAGGCTGCAGACCCTGCAC
TTGCAATCCCGCTGGCAGCCTGGACACCTGTGACCCCCGCAGTGGGCGCTGCCCCTGCAAAGAGAATGTGGAAGGCAACCTATGTGACAG
ATGTCGCCCGGGGACCTTTAACCTGCAGCCCCACAATCCAGCTGGCTGCAGCAGCTGTTTCTGCTATGGCCACTCCAAGGTGTGCGCGTC
CACTGCCCAGTTCCAGGTGCATCACATCCTCAGCGATTTCCACCAGGGAGCCGAAGGCTGGTGGGCCAGAAGTGTGGGGGGCTCTGAGCA
CCCCCCACAATGGAGCCCAAATGGGGTCCTCCTGAGCCCAGAAGACGAGGAGGAGCTCACAGCACCAGAGAAGTTCCTGGGAGACCAGCG
GTTCAGCTATGGGCAGCCCCTCATACTGACCTTCCGGGTGCCCCCCGGGGACTCCCCACTCCCTGTACAGCTGAGGCTGGAAGGGACAGG
CTTGGCCCTGTCCCTGAGGCACTCTAGCCTGTCTGGCCCCCAGGATGCCGGGCATCCCAGGGAGGTAGAGCTCAGGTTCCACCTGCAGGA
GACCTCCGAGGACGTGGCCCCTCCACTGCCCCCCTTCCACTTCCAGCGGCTCCTCGCCAACCTGACCAGCCTCCGCCTCCGCGTCAGTCC
CGGCCCCAGCCCTGCCGGTCCAGTGTTCCTGACTGAGGTCCGGCTCACATCCGCCCGGCCAGGGCTTTCCCCGCCAGCCTCCTGGGTGGA
GATTTGTTCATGTCCCACTGGCTACACGGGCCAGTTCTGTGAATCCTGTGCTCCGGGATACAAGAGGGAGATGCCACAGGGGGGTCCCTA
TGCCAGCTGTGTCCCCTGCACCTGTAACCAGCATGGCACCTGTGACCCCAACACAGGGATCTGTGTCTGCAGCCACCATACCGAGGGCCC
ATCCTGTGAACGCTGTTTGCCAGGTTTCTATGGCAACCCTTTCGCGGGCCAAGCCGACGACTGCCAGCCCTGTCCCTGCCCTGGCCAGTC
GGCCTGTACGACCATCCCAGAGAGCCGGGAGGTGGTGTGTACCCACTGCCCCCCGGGCCAGAGAGGGCGGCGCTGTGAGGTCTGTGATGA
TGGCTTTTTTGGGGACCCGCTGGGGCTCTTTGGGCACCCCCAGCCCTGCCACCAGTGCCAGTGTAGCGGGAACGTGGACCCCAATGCCGT
GGGCAACTGTGACCCCCTGTCTGGCCACTGCCTGCGCTGCCTGCACAACACCACGGGTGACCACTGTGAGCACTGTCAGGAAGGCTTCTA
CGGGAGCGCCCTGGCCCCTCGACCCGCAGACAAATGCATGCCTTGCAGCTGTCACCCACAGGGCTCGGTCAGTGAGCAGATGCCCTGCGA
CCCAGTGACAGGCCAATGCTCCTGCCTGCCTCATGTGACTGCACGGGACTGCAGCCGCTGCTACCCTGGCTTCTTCGACCTCCAGCCTGG
GAGGGGCTGCCGGAGCTGCAAGTGTCACCCACTGGGCTCCCAGGAGGACCAGTGCCATCCCAAGACTGGACAGTGCACCTGCCGCCCAGG
TGTCACAGGCCAGGCCTGTGACAGGTGCCAGCTGGGTTTCTTCGGCTTCTCCATCAAGGGCTGCCGGGCCTGCAGGTGCTCCCCACTGGG
CGCTGCCTCGGCCCAGTGCCACGAGAACGGCACATGCGTGTGCAGGCCTGGCTTCGAGGGCTACAAATGTGACCGCTGCCACGACAACTT
CTTCCTCACGGCAGACGGCACACACTGCCAGCAATGTCCGTCCTGCTACGCCCTGGTGAAGGAGGAGGCAGCCAAGCTGAAGGCCAGACT
GACTTTGACGGAGGGGTGGCTCCAAGGGTCCGACTGTGGCAGTCCCTGGGGACCACTAGACATTCTGCTGGGAGAGGCCCCAAGGGGGGA
CGTCTACCAGGGCCATCACCTGCTTCCAGGGGCTCGGGAAGCCTTCCTGGAGCAGATGATGAGCCTCGAGGGTGCTGTCAAGGCCGCCCG
GGAGCAGCTGCAGAGGCTGAACAAGGGTGCCCGCTGTGCCCAGGCCGGATCCCAGAAGACCTGCACCCAGCTGGCAGACCTGGAGGCAGT
GCTGGAGTCCTCGGAAGAGGAGATTCTGCATGCAGCTGCCATTCTCGCGTCTCTGGAGATTCCTCAGGAAGGTCCCAGTCAGCCGACCAA
ATGGAGCCACCTGGCCACAGAGGCCCGTGCCCTCGCCAGGAGCCACAGAGACACCGCCACCAAGATCGCAGCCACTGCTTGGAGGGCCCT
GCTCGCCTCCAACACCAGCTACGCGCTTCTCTGGAATCTGCTGGAGGGAAGGGTGGCCCTAGAGACCCAGCGGGACCTGGAGGACAGGTA
CCAGGAGGTCCAGGCGGCCCAGAAAGCACTGAGGACGGCTGTGGCAGAGGTGCTGCCTGAAGCGGAAAGCGTGTTGGCCACCGTGCAGCA
AGTTGGCGCAGATACAGCCCCGTACCTGGCCTTGCTGGCTTCCCCGGGAGCTCTGCCTCAGAAGTCCCGGGCTGAAGACCTGGGCCTGAA
GGCGAAGGCCCTGGAGAAGACAGTTGCATCATGGCAGCACATGGCCACTGAGGCTGCCCGAACCCTCCAGACTGCTGCCCAGGCGACGCT
ACGGCAAACAGAACCCCTCACAAAGCTGCACCAGGAGGCCAGAGCCGCCCTGACCCAGGCTTCCTCATCTGTCCAGGCTGCGACAGTGAC
TGTCATGGGAGCCAGGACTCTGCTGGCTGATCTGGAAGGAATGAAGCTGCAGTTTCCCCGGCCCAAGGACCAGGCGGCATTGCAGAGGAA
GGCAGACTCCGTCAGTGACAGACTCCTTGCAGACACGAGAAAGAAGACCAAGCAGGCGGAGAGGATGCTGGGAAACGCGGCCCCTCTTTC
CTCCAGTGCCAAGAAGAAGGGCAGAGAAGCAGAGGTGTTGGCCAAGGACAGTGCCAAGCTTGCCAAGGCCTTGCTGAGGGAGCGGAAACA
GGCGCACCGCCGTGCCAGCAGGCTCACCAGCCAGACGCAAGCCACGCTCCAACAGGCGTCCCAGCAGGTGCTGGCGTCTGAAGCACGCAG
ACAGGAGCTGGAGGAAGCTGAGCGGGTGGGTGCTGGGCTGAGCGAGATGGAGCAGCAGATCCGGGAATCGCGTATCTCACTGGAGAAGGA
CATCGAGACCTTGTCAGAGCTGCTTGCCAGGCTGGGGTCGCTGGACACCCATCAAGCCCCAGCCCAGGCCCTGAACGAGACTCAGTGGGC
ACTAGAACGCCTGAGGCTGCAGCTGGGCTCCCCGGGGTCCTTGCAGAGGAAACTCAGTCTGCTGGAGCAGGAATCCCAGCAGCAGGAGCT
GCAGATCCAGGGCTTCGAGAGTGACCTCGCCGAGATCCGCGCCGACAAACAGAACCTGGAGGCCATTCTGCACAGCCTGCCCGAGAACTG
TGCCAGCTGGCAGTGAGGGCTGCCCAGATCCCCGGCACACACTCCCCCACCTGCTGTTTACATGACCCAGGGGGTGCACACTACCCCACA
GGTGTGCCCATACAGACATTCCCCGGAGCCGGCTGCTGTGAACTCGCCCCCGTGTGGATAGTCACTCCCTGCCGATTCTGTCTGTGGCTT
CTTCCCTGCCAGCAGGACTGAGTGTGCGTACCCAGTTCACCTGGACATGAGTGCACACTCTCACCCCTGCACATGCATAAACGGGCACAC
CCCAGTGTCAATAACATACACACGTGAGGGTGCATGTCTGTGTGTATGACCCACACGTGTTCAAGTCTAATCCATCCAGTCAGCAGCTTA
CGGTCCACACACATTACAGTCCACAGCTGTTGTGAGAGCCACCTGTGTGCTGGACACCCTCTGGATGTTGGGCAAGTTGTTACATGAGAT
GCCCTGGGGTGCTACATCCACTCACTCCAGATAGCAGGGAGGTCTCAGCAGATCTGCAGAGATCAAGGGGGTCAGCAACAGCCAAAGCCC
CTAGTCCCAGAGCTGGCTGCCCTCTGTTTCACAGCAGCTCCCTGACCTGTGTTGCTGCGTGCACTCCCTACAGCTCGACACAGCCAGGGG
ACCAACAGGCCAAGAAATGCAAGATCCCGGGAGGGTTCTTAGCAGCAGAATCTGAGGCCCAGAGACCCTGAGGCCGTGGCCAGGCCTGCT
AGTCTGGCTAGAGCAAGGCCCATTCCTGGCGGGGGTGTCATTGCCTTCACCGGACGCTTCCCTCTCAGGGTCCTGGGACTGCACCAGATG
CCCTGAGGGAATGGCCCACCCTGGCCTGTACCCACTTCAGCCTGTGATCTATCCAAAGAGCCAGGCCCAAAAGCGCCTAGGTCAGGGTGC
TCAGGCTACCAGGAGCACGCCTCTGTGCCCCCGGCAACCCAGTTGACCTTTAATTGACGCTTTCCAGACCAGCCCTGCGGCACCACTTGC
CATGCGGGAGGCCACCAGGGTGTGCAAGCCTGGCTGCCATTCCAGTCTGTCCTGTCTGGGAATCGCCCTGTGGCCAGGCCCGCATGCTGG
CCTCTGCCCAGGACTCCTCAGCATTTCCTCTTGGCATCCCTCCCCTCTCCCAGACCCTCTTCCAGCAGATGGCAAGGCCTCGGCATTGGG
AAGTCAGGCACCTCTGCGGGCCCAGCCCCCTCCCGTGGCTCCCCTGACAGGGGCAGGGGTAGGGCAGCAGCACAGACCAATTCCGTTGAA

>14501_14501_1_CD40-LAMC3_CD40_chr20_44751395_ENST00000372276_LAMC3_chr9_133901672_ENST00000361069_length(amino acids)=1585AA_BP=134
MVRLPLQCVLWGCLLTAVHPEPPTACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCDPNLGLR
VQQKGTSETDTICTCEEGWHCTSEACESCVLHRSCSPGFGVKQIGKAYEITYVRLKFHTSRPESFAIYKRSRADGPWEPYQFYSASCQKT
YGRPEGQYLRPGEDERVAFCTSEFSDISPLSGGNVAFSTLEGRPSAYNFEESPGLQEWVTSTELLISLDRLNTFGDDIFKDPKVLQSYYY
AVSDFSVGGRCKCNGHASECGPDVAGQLACRCQHNTTGTDCERCLPFFQDRPWARGTAEAAHECLPCNCSGRSEECTFDRELFRSTGHGG
RCHHCRDHTAGPHCERCQENFYHWDPRMPCQPCDCQSAGSLHLQCDDTGTCACKPTVTGWKCDRCLPGFHSLSEGGCRPCTCNPAGSLDT
CDPRSGRCPCKENVEGNLCDRCRPGTFNLQPHNPAGCSSCFCYGHSKVCASTAQFQVHHILSDFHQGAEGWWARSVGGSEHPPQWSPNGV
LLSPEDEEELTAPEKFLGDQRFSYGQPLILTFRVPPGDSPLPVQLRLEGTGLALSLRHSSLSGPQDAGHPREVELRFHLQETSEDVAPPL
PPFHFQRLLANLTSLRLRVSPGPSPAGPVFLTEVRLTSARPGLSPPASWVEICSCPTGYTGQFCESCAPGYKREMPQGGPYASCVPCTCN
QHGTCDPNTGICVCSHHTEGPSCERCLPGFYGNPFAGQADDCQPCPCPGQSACTTIPESREVVCTHCPPGQRGRRCEVCDDGFFGDPLGL
FGHPQPCHQCQCSGNVDPNAVGNCDPLSGHCLRCLHNTTGDHCEHCQEGFYGSALAPRPADKCMPCSCHPQGSVSEQMPCDPVTGQCSCL
PHVTARDCSRCYPGFFDLQPGRGCRSCKCHPLGSQEDQCHPKTGQCTCRPGVTGQACDRCQLGFFGFSIKGCRACRCSPLGAASAQCHEN
GTCVCRPGFEGYKCDRCHDNFFLTADGTHCQQCPSCYALVKEEAAKLKARLTLTEGWLQGSDCGSPWGPLDILLGEAPRGDVYQGHHLLP
GAREAFLEQMMSLEGAVKAAREQLQRLNKGARCAQAGSQKTCTQLADLEAVLESSEEEILHAAAILASLEIPQEGPSQPTKWSHLATEAR
ALARSHRDTATKIAATAWRALLASNTSYALLWNLLEGRVALETQRDLEDRYQEVQAAQKALRTAVAEVLPEAESVLATVQQVGADTAPYL
ALLASPGALPQKSRAEDLGLKAKALEKTVASWQHMATEAARTLQTAAQATLRQTEPLTKLHQEARAALTQASSSVQAATVTVMGARTLLA
DLEGMKLQFPRPKDQAALQRKADSVSDRLLADTRKKTKQAERMLGNAAPLSSSAKKKGREAEVLAKDSAKLAKALLRERKQAHRRASRLT
SQTQATLQQASQQVLASEARRQELEEAERVGAGLSEMEQQIRESRISLEKDIETLSELLARLGSLDTHQAPAQALNETQWALERLRLQLG

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>14501_14501_2_CD40-LAMC3_CD40_chr20_44751395_ENST00000372285_LAMC3_chr9_133901672_ENST00000361069_length(transcript)=6102nt_BP=475nt
GGCTGGGGCAGGGGAGTCAGCAGAGGCCTCGCTCGGGCGCCCAGTGGTCCTGCCGCCTGGTCTCACCTCGCTATGGTTCGTCTGCCTCTG
CAGTGCGTCCTCTGGGGCTGCTTGCTGACCGCTGTCCATCCAGAACCACCCACTGCATGCAGAGAAAAACAGTACCTAATAAACAGTCAG
TGCTGTTCTTTGTGCCAGCCAGGACAGAAACTGGTGAGTGACTGCACAGAGTTCACTGAAACGGAATGCCTTCCTTGCGGTGAAAGCGAA
TTCCTAGACACCTGGAACAGAGAGACACACTGCCACCAGCACAAATACTGCGACCCCAACCTAGGGCTTCGGGTCCAGCAGAAGGGCACC
TCAGAAACAGACACCATCTGCACCTGTGAAGAAGGCTGGCACTGTACGAGTGAGGCCTGTGAGAGCTGTGTCCTGCACCGCTCATGCTCG
CCCGGCTTTGGGGTCAAGCAGATTGGGAAGGCTTATGAGATCACGTATGTGAGGCTGAAGTTCCACACCAGTCGCCCTGAGAGCTTTGCC
ATCTACAAGCGCAGCCGCGCCGACGGCCCATGGGAGCCCTACCAGTTCTACAGCGCCTCCTGCCAGAAGACCTACGGCCGGCCCGAGGGC
CAGTACCTGCGCCCCGGCGAGGACGAGCGCGTGGCCTTCTGCACCTCTGAGTTCAGCGACATCTCCCCGCTGAGTGGCGGCAACGTGGCC
TTCTCCACCCTGGAGGGCCGGCCCAGCGCCTACAACTTCGAGGAGAGCCCTGGGCTGCAGGAGTGGGTCACCAGCACCGAACTCCTCATC
TCTCTAGACCGGCTCAACACGTTTGGGGACGACATCTTCAAGGACCCCAAGGTGCTCCAGTCCTACTATTATGCCGTGTCCGACTTCTCT
GTGGGCGGCAGGTGCAAGTGCAACGGGCATGCCAGCGAGTGCGGCCCCGACGTGGCAGGCCAGTTGGCCTGCCGGTGCCAGCACAACACC
ACCGGCACAGACTGTGAGCGCTGCCTGCCCTTCTTCCAGGACCGCCCGTGGGCCCGGGGCACCGCCGAGGCTGCCCACGAGTGTCTGCCC
TGCAACTGCAGTGGCCGCTCCGAGGAATGCACGTTTGATCGGGAGCTCTTCCGCAGCACAGGCCACGGCGGGCGCTGTCACCACTGCCGT
GACCACACAGCTGGGCCACACTGTGAGCGCTGTCAGGAGAATTTCTATCACTGGGACCCGCGGATGCCATGCCAGCCCTGTGACTGCCAG
TCGGCAGGCTCCCTACACCTCCAGTGCGATGACACAGGCACCTGCGCCTGCAAGCCCACGGTGACTGGCTGGAAGTGTGACCGCTGTCTG
CCCGGGTTCCACTCGCTCAGTGAGGGAGGCTGCAGACCCTGCACTTGCAATCCCGCTGGCAGCCTGGACACCTGTGACCCCCGCAGTGGG
CGCTGCCCCTGCAAAGAGAATGTGGAAGGCAACCTATGTGACAGATGTCGCCCGGGGACCTTTAACCTGCAGCCCCACAATCCAGCTGGC
TGCAGCAGCTGTTTCTGCTATGGCCACTCCAAGGTGTGCGCGTCCACTGCCCAGTTCCAGGTGCATCACATCCTCAGCGATTTCCACCAG
GGAGCCGAAGGCTGGTGGGCCAGAAGTGTGGGGGGCTCTGAGCACCCCCCACAATGGAGCCCAAATGGGGTCCTCCTGAGCCCAGAAGAC
GAGGAGGAGCTCACAGCACCAGAGAAGTTCCTGGGAGACCAGCGGTTCAGCTATGGGCAGCCCCTCATACTGACCTTCCGGGTGCCCCCC
GGGGACTCCCCACTCCCTGTACAGCTGAGGCTGGAAGGGACAGGCTTGGCCCTGTCCCTGAGGCACTCTAGCCTGTCTGGCCCCCAGGAT
GCCGGGCATCCCAGGGAGGTAGAGCTCAGGTTCCACCTGCAGGAGACCTCCGAGGACGTGGCCCCTCCACTGCCCCCCTTCCACTTCCAG
CGGCTCCTCGCCAACCTGACCAGCCTCCGCCTCCGCGTCAGTCCCGGCCCCAGCCCTGCCGGTCCAGTGTTCCTGACTGAGGTCCGGCTC
ACATCCGCCCGGCCAGGGCTTTCCCCGCCAGCCTCCTGGGTGGAGATTTGTTCATGTCCCACTGGCTACACGGGCCAGTTCTGTGAATCC
TGTGCTCCGGGATACAAGAGGGAGATGCCACAGGGGGGTCCCTATGCCAGCTGTGTCCCCTGCACCTGTAACCAGCATGGCACCTGTGAC
CCCAACACAGGGATCTGTGTCTGCAGCCACCATACCGAGGGCCCATCCTGTGAACGCTGTTTGCCAGGTTTCTATGGCAACCCTTTCGCG
GGCCAAGCCGACGACTGCCAGCCCTGTCCCTGCCCTGGCCAGTCGGCCTGTACGACCATCCCAGAGAGCCGGGAGGTGGTGTGTACCCAC
TGCCCCCCGGGCCAGAGAGGGCGGCGCTGTGAGGTCTGTGATGATGGCTTTTTTGGGGACCCGCTGGGGCTCTTTGGGCACCCCCAGCCC
TGCCACCAGTGCCAGTGTAGCGGGAACGTGGACCCCAATGCCGTGGGCAACTGTGACCCCCTGTCTGGCCACTGCCTGCGCTGCCTGCAC
AACACCACGGGTGACCACTGTGAGCACTGTCAGGAAGGCTTCTACGGGAGCGCCCTGGCCCCTCGACCCGCAGACAAATGCATGCCTTGC
AGCTGTCACCCACAGGGCTCGGTCAGTGAGCAGATGCCCTGCGACCCAGTGACAGGCCAATGCTCCTGCCTGCCTCATGTGACTGCACGG
GACTGCAGCCGCTGCTACCCTGGCTTCTTCGACCTCCAGCCTGGGAGGGGCTGCCGGAGCTGCAAGTGTCACCCACTGGGCTCCCAGGAG
GACCAGTGCCATCCCAAGACTGGACAGTGCACCTGCCGCCCAGGTGTCACAGGCCAGGCCTGTGACAGGTGCCAGCTGGGTTTCTTCGGC
TTCTCCATCAAGGGCTGCCGGGCCTGCAGGTGCTCCCCACTGGGCGCTGCCTCGGCCCAGTGCCACGAGAACGGCACATGCGTGTGCAGG
CCTGGCTTCGAGGGCTACAAATGTGACCGCTGCCACGACAACTTCTTCCTCACGGCAGACGGCACACACTGCCAGCAATGTCCGTCCTGC
TACGCCCTGGTGAAGGAGGAGGCAGCCAAGCTGAAGGCCAGACTGACTTTGACGGAGGGGTGGCTCCAAGGGTCCGACTGTGGCAGTCCC
TGGGGACCACTAGACATTCTGCTGGGAGAGGCCCCAAGGGGGGACGTCTACCAGGGCCATCACCTGCTTCCAGGGGCTCGGGAAGCCTTC
CTGGAGCAGATGATGAGCCTCGAGGGTGCTGTCAAGGCCGCCCGGGAGCAGCTGCAGAGGCTGAACAAGGGTGCCCGCTGTGCCCAGGCC
GGATCCCAGAAGACCTGCACCCAGCTGGCAGACCTGGAGGCAGTGCTGGAGTCCTCGGAAGAGGAGATTCTGCATGCAGCTGCCATTCTC
GCGTCTCTGGAGATTCCTCAGGAAGGTCCCAGTCAGCCGACCAAATGGAGCCACCTGGCCACAGAGGCCCGTGCCCTCGCCAGGAGCCAC
AGAGACACCGCCACCAAGATCGCAGCCACTGCTTGGAGGGCCCTGCTCGCCTCCAACACCAGCTACGCGCTTCTCTGGAATCTGCTGGAG
GGAAGGGTGGCCCTAGAGACCCAGCGGGACCTGGAGGACAGGTACCAGGAGGTCCAGGCGGCCCAGAAAGCACTGAGGACGGCTGTGGCA
GAGGTGCTGCCTGAAGCGGAAAGCGTGTTGGCCACCGTGCAGCAAGTTGGCGCAGATACAGCCCCGTACCTGGCCTTGCTGGCTTCCCCG
GGAGCTCTGCCTCAGAAGTCCCGGGCTGAAGACCTGGGCCTGAAGGCGAAGGCCCTGGAGAAGACAGTTGCATCATGGCAGCACATGGCC
ACTGAGGCTGCCCGAACCCTCCAGACTGCTGCCCAGGCGACGCTACGGCAAACAGAACCCCTCACAAAGCTGCACCAGGAGGCCAGAGCC
GCCCTGACCCAGGCTTCCTCATCTGTCCAGGCTGCGACAGTGACTGTCATGGGAGCCAGGACTCTGCTGGCTGATCTGGAAGGAATGAAG
CTGCAGTTTCCCCGGCCCAAGGACCAGGCGGCATTGCAGAGGAAGGCAGACTCCGTCAGTGACAGACTCCTTGCAGACACGAGAAAGAAG
ACCAAGCAGGCGGAGAGGATGCTGGGAAACGCGGCCCCTCTTTCCTCCAGTGCCAAGAAGAAGGGCAGAGAAGCAGAGGTGTTGGCCAAG
GACAGTGCCAAGCTTGCCAAGGCCTTGCTGAGGGAGCGGAAACAGGCGCACCGCCGTGCCAGCAGGCTCACCAGCCAGACGCAAGCCACG
CTCCAACAGGCGTCCCAGCAGGTGCTGGCGTCTGAAGCACGCAGACAGGAGCTGGAGGAAGCTGAGCGGGTGGGTGCTGGGCTGAGCGAG
ATGGAGCAGCAGATCCGGGAATCGCGTATCTCACTGGAGAAGGACATCGAGACCTTGTCAGAGCTGCTTGCCAGGCTGGGGTCGCTGGAC
ACCCATCAAGCCCCAGCCCAGGCCCTGAACGAGACTCAGTGGGCACTAGAACGCCTGAGGCTGCAGCTGGGCTCCCCGGGGTCCTTGCAG
AGGAAACTCAGTCTGCTGGAGCAGGAATCCCAGCAGCAGGAGCTGCAGATCCAGGGCTTCGAGAGTGACCTCGCCGAGATCCGCGCCGAC
AAACAGAACCTGGAGGCCATTCTGCACAGCCTGCCCGAGAACTGTGCCAGCTGGCAGTGAGGGCTGCCCAGATCCCCGGCACACACTCCC
CCACCTGCTGTTTACATGACCCAGGGGGTGCACACTACCCCACAGGTGTGCCCATACAGACATTCCCCGGAGCCGGCTGCTGTGAACTCG
CCCCCGTGTGGATAGTCACTCCCTGCCGATTCTGTCTGTGGCTTCTTCCCTGCCAGCAGGACTGAGTGTGCGTACCCAGTTCACCTGGAC
ATGAGTGCACACTCTCACCCCTGCACATGCATAAACGGGCACACCCCAGTGTCAATAACATACACACGTGAGGGTGCATGTCTGTGTGTA
TGACCCACACGTGTTCAAGTCTAATCCATCCAGTCAGCAGCTTACGGTCCACACACATTACAGTCCACAGCTGTTGTGAGAGCCACCTGT
GTGCTGGACACCCTCTGGATGTTGGGCAAGTTGTTACATGAGATGCCCTGGGGTGCTACATCCACTCACTCCAGATAGCAGGGAGGTCTC
AGCAGATCTGCAGAGATCAAGGGGGTCAGCAACAGCCAAAGCCCCTAGTCCCAGAGCTGGCTGCCCTCTGTTTCACAGCAGCTCCCTGAC
CTGTGTTGCTGCGTGCACTCCCTACAGCTCGACACAGCCAGGGGACCAACAGGCCAAGAAATGCAAGATCCCGGGAGGGTTCTTAGCAGC
AGAATCTGAGGCCCAGAGACCCTGAGGCCGTGGCCAGGCCTGCTAGTCTGGCTAGAGCAAGGCCCATTCCTGGCGGGGGTGTCATTGCCT
TCACCGGACGCTTCCCTCTCAGGGTCCTGGGACTGCACCAGATGCCCTGAGGGAATGGCCCACCCTGGCCTGTACCCACTTCAGCCTGTG
ATCTATCCAAAGAGCCAGGCCCAAAAGCGCCTAGGTCAGGGTGCTCAGGCTACCAGGAGCACGCCTCTGTGCCCCCGGCAACCCAGTTGA
CCTTTAATTGACGCTTTCCAGACCAGCCCTGCGGCACCACTTGCCATGCGGGAGGCCACCAGGGTGTGCAAGCCTGGCTGCCATTCCAGT
CTGTCCTGTCTGGGAATCGCCCTGTGGCCAGGCCCGCATGCTGGCCTCTGCCCAGGACTCCTCAGCATTTCCTCTTGGCATCCCTCCCCT
CTCCCAGACCCTCTTCCAGCAGATGGCAAGGCCTCGGCATTGGGAAGTCAGGCACCTCTGCGGGCCCAGCCCCCTCCCGTGGCTCCCCTG

>14501_14501_2_CD40-LAMC3_CD40_chr20_44751395_ENST00000372285_LAMC3_chr9_133901672_ENST00000361069_length(amino acids)=1585AA_BP=134
MVRLPLQCVLWGCLLTAVHPEPPTACREKQYLINSQCCSLCQPGQKLVSDCTEFTETECLPCGESEFLDTWNRETHCHQHKYCDPNLGLR
VQQKGTSETDTICTCEEGWHCTSEACESCVLHRSCSPGFGVKQIGKAYEITYVRLKFHTSRPESFAIYKRSRADGPWEPYQFYSASCQKT
YGRPEGQYLRPGEDERVAFCTSEFSDISPLSGGNVAFSTLEGRPSAYNFEESPGLQEWVTSTELLISLDRLNTFGDDIFKDPKVLQSYYY
AVSDFSVGGRCKCNGHASECGPDVAGQLACRCQHNTTGTDCERCLPFFQDRPWARGTAEAAHECLPCNCSGRSEECTFDRELFRSTGHGG
RCHHCRDHTAGPHCERCQENFYHWDPRMPCQPCDCQSAGSLHLQCDDTGTCACKPTVTGWKCDRCLPGFHSLSEGGCRPCTCNPAGSLDT
CDPRSGRCPCKENVEGNLCDRCRPGTFNLQPHNPAGCSSCFCYGHSKVCASTAQFQVHHILSDFHQGAEGWWARSVGGSEHPPQWSPNGV
LLSPEDEEELTAPEKFLGDQRFSYGQPLILTFRVPPGDSPLPVQLRLEGTGLALSLRHSSLSGPQDAGHPREVELRFHLQETSEDVAPPL
PPFHFQRLLANLTSLRLRVSPGPSPAGPVFLTEVRLTSARPGLSPPASWVEICSCPTGYTGQFCESCAPGYKREMPQGGPYASCVPCTCN
QHGTCDPNTGICVCSHHTEGPSCERCLPGFYGNPFAGQADDCQPCPCPGQSACTTIPESREVVCTHCPPGQRGRRCEVCDDGFFGDPLGL
FGHPQPCHQCQCSGNVDPNAVGNCDPLSGHCLRCLHNTTGDHCEHCQEGFYGSALAPRPADKCMPCSCHPQGSVSEQMPCDPVTGQCSCL
PHVTARDCSRCYPGFFDLQPGRGCRSCKCHPLGSQEDQCHPKTGQCTCRPGVTGQACDRCQLGFFGFSIKGCRACRCSPLGAASAQCHEN
GTCVCRPGFEGYKCDRCHDNFFLTADGTHCQQCPSCYALVKEEAAKLKARLTLTEGWLQGSDCGSPWGPLDILLGEAPRGDVYQGHHLLP
GAREAFLEQMMSLEGAVKAAREQLQRLNKGARCAQAGSQKTCTQLADLEAVLESSEEEILHAAAILASLEIPQEGPSQPTKWSHLATEAR
ALARSHRDTATKIAATAWRALLASNTSYALLWNLLEGRVALETQRDLEDRYQEVQAAQKALRTAVAEVLPEAESVLATVQQVGADTAPYL
ALLASPGALPQKSRAEDLGLKAKALEKTVASWQHMATEAARTLQTAAQATLRQTEPLTKLHQEARAALTQASSSVQAATVTVMGARTLLA
DLEGMKLQFPRPKDQAALQRKADSVSDRLLADTRKKTKQAERMLGNAAPLSSSAKKKGREAEVLAKDSAKLAKALLRERKQAHRRASRLT
SQTQATLQQASQQVLASEARRQELEEAERVGAGLSEMEQQIRESRISLEKDIETLSELLARLGSLDTHQAPAQALNETQWALERLRLQLG

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Fusion Gene PPI Analysis for CD40-LAMC3


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CD40-LAMC3


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CD40-LAMC3


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCD40C0003873Rheumatoid Arthritis3CTD_human
HgeneCD40C1720957Hyper-IgM Immunodeficiency Syndrome, Type 33CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneCD40C0026691Mucocutaneous Lymph Node Syndrome2CTD_human
HgeneCD40C0006142Malignant neoplasm of breast1CTD_human
HgeneCD40C0020456Hyperglycemia1CTD_human
HgeneCD40C0020459Hyperinsulinism1CTD_human
HgeneCD40C0021655Insulin Resistance1CTD_human
HgeneCD40C0026769Multiple Sclerosis1CTD_human
HgeneCD40C0028754Obesity1CTD_human
HgeneCD40C0038220Status Epilepticus1CTD_human
HgeneCD40C0270823Petit mal status1CTD_human
HgeneCD40C0311335Grand Mal Status Epilepticus1CTD_human
HgeneCD40C0393734Complex Partial Status Epilepticus1CTD_human
HgeneCD40C0678222Breast Carcinoma1CTD_human
HgeneCD40C0751324Multiple Sclerosis, Acute Fulminating1CTD_human
HgeneCD40C0751522Status Epilepticus, Subclinical1CTD_human
HgeneCD40C0751523Non-Convulsive Status Epilepticus1CTD_human
HgeneCD40C0751524Simple Partial Status Epilepticus1CTD_human
HgeneCD40C0920563Insulin Sensitivity1CTD_human
HgeneCD40C1257931Mammary Neoplasms, Human1CTD_human
HgeneCD40C1257963Endogenous Hyperinsulinism1CTD_human
HgeneCD40C1257964Exogenous Hyperinsulinism1CTD_human
HgeneCD40C1257965Compensatory Hyperinsulinemia1CTD_human
HgeneCD40C1458155Mammary Neoplasms1CTD_human
HgeneCD40C1855520Hyperglycemia, Postprandial1CTD_human
HgeneCD40C4704874Mammary Carcinoma, Human1CTD_human
TgeneC1510586Autism Spectrum Disorders2CTD_human
TgeneC0006111Brain Diseases1CTD_human
TgeneC0026640Mouth Neoplasms1CTD_human
TgeneC0085584Encephalopathies1CTD_human
TgeneC0153381Malignant neoplasm of mouth1CTD_human
TgeneC3279875CORTICAL MALFORMATIONS, OCCIPITAL1CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT