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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CD58-RAD51B (FusionGDB2 ID:HG965TG5890)

Fusion Gene Summary for CD58-RAD51B

check button Fusion gene summary
Fusion gene informationFusion gene name: CD58-RAD51B
Fusion gene ID: hg965tg5890
HgeneTgene
Gene symbol

CD58

RAD51B

Gene ID

965

5890

Gene nameCD58 moleculeRAD51 paralog B
SynonymsLFA-3|LFA3|ag3R51H2|RAD51L1|REC2
Cytomap('CD58')('RAD51B')

1p13.1

14q24.1

Type of geneprotein-codingprotein-coding
Descriptionlymphocyte function-associated antigen 3CD58 antigen, (lymphocyte function-associated antigen 3)surface glycoprotein LFA-3DNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair protein
Modification date2020031320200313
UniProtAcc.

O15315

Ensembl transtripts involved in fusion geneENST00000369487, ENST00000369489, 
ENST00000457047, 
Fusion gene scores* DoF score6 X 5 X 5=15041 X 23 X 12=11316
# samples 656
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(56/11316*10)=-4.33679344445129
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CD58 [Title/Abstract] AND RAD51B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCD58(117113525)-RAD51B(68758601), # samples:2
Anticipated loss of major functional domain due to fusion event.CD58-RAD51B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CD58-RAD51B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD58

GO:0034113

heterotypic cell-cell adhesion

15345303

HgeneCD58

GO:0071346

cellular response to interferon-gamma

19109405

HgeneCD58

GO:0071356

cellular response to tumor necrosis factor

19109405


check buttonFusion gene breakpoints across CD58 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across RAD51B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-B6-A400-01ACD58chr1

117113525

-RAD51Bchr14

68758601

+


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Fusion Gene ORF analysis for CD58-RAD51B

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000369487ENST00000469165CD58chr1

117113525

-RAD51Bchr14

68758601

+
5CDS-3UTRENST00000369489ENST00000469165CD58chr1

117113525

-RAD51Bchr14

68758601

+
5CDS-3UTRENST00000457047ENST00000469165CD58chr1

117113525

-RAD51Bchr14

68758601

+
In-frameENST00000369487ENST00000390683CD58chr1

117113525

-RAD51Bchr14

68758601

+
In-frameENST00000369487ENST00000471583CD58chr1

117113525

-RAD51Bchr14

68758601

+
In-frameENST00000369487ENST00000487270CD58chr1

117113525

-RAD51Bchr14

68758601

+
In-frameENST00000369487ENST00000487861CD58chr1

117113525

-RAD51Bchr14

68758601

+
In-frameENST00000369487ENST00000488612CD58chr1

117113525

-RAD51Bchr14

68758601

+
In-frameENST00000369489ENST00000390683CD58chr1

117113525

-RAD51Bchr14

68758601

+
In-frameENST00000369489ENST00000471583CD58chr1

117113525

-RAD51Bchr14

68758601

+
In-frameENST00000369489ENST00000487270CD58chr1

117113525

-RAD51Bchr14

68758601

+
In-frameENST00000369489ENST00000487861CD58chr1

117113525

-RAD51Bchr14

68758601

+
In-frameENST00000369489ENST00000488612CD58chr1

117113525

-RAD51Bchr14

68758601

+
In-frameENST00000457047ENST00000390683CD58chr1

117113525

-RAD51Bchr14

68758601

+
In-frameENST00000457047ENST00000471583CD58chr1

117113525

-RAD51Bchr14

68758601

+
In-frameENST00000457047ENST00000487270CD58chr1

117113525

-RAD51Bchr14

68758601

+
In-frameENST00000457047ENST00000487861CD58chr1

117113525

-RAD51Bchr14

68758601

+
In-frameENST00000457047ENST00000488612CD58chr1

117113525

-RAD51Bchr14

68758601

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000369489CD58chr1117113525-ENST00000487861RAD51Bchr1468758601+97713711658215
ENST00000369489CD58chr1117113525-ENST00000471583RAD51Bchr1468758601+86913711433140
ENST00000369489CD58chr1117113525-ENST00000487270RAD51Bchr1468758601+192913711535174
ENST00000369489CD58chr1117113525-ENST00000488612RAD51Bchr1468758601+90413711481156
ENST00000369489CD58chr1117113525-ENST00000390683RAD51Bchr1468758601+48213711481157
ENST00000457047CD58chr1117113525-ENST00000487861RAD51Bchr1468758601+96412410645211
ENST00000457047CD58chr1117113525-ENST00000471583RAD51Bchr1468758601+85612410420136
ENST00000457047CD58chr1117113525-ENST00000487270RAD51Bchr1468758601+191612410522170
ENST00000457047CD58chr1117113525-ENST00000488612RAD51Bchr1468758601+89112410468152
ENST00000457047CD58chr1117113525-ENST00000390683RAD51Bchr1468758601+46912410468153
ENST00000369487CD58chr1117113525-ENST00000487861RAD51Bchr1468758601+97713711658215
ENST00000369487CD58chr1117113525-ENST00000471583RAD51Bchr1468758601+86913711433140
ENST00000369487CD58chr1117113525-ENST00000487270RAD51Bchr1468758601+192913711535174
ENST00000369487CD58chr1117113525-ENST00000488612RAD51Bchr1468758601+90413711481156
ENST00000369487CD58chr1117113525-ENST00000390683RAD51Bchr1468758601+48213711481157

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369489ENST00000487861CD58chr1117113525-RAD51Bchr1468758601+0.61469280.38530725
ENST00000369489ENST00000471583CD58chr1117113525-RAD51Bchr1468758601+0.60947650.39052346
ENST00000369489ENST00000487270CD58chr1117113525-RAD51Bchr1468758601+0.70213240.29786763
ENST00000369489ENST00000488612CD58chr1117113525-RAD51Bchr1468758601+0.169215650.8307843
ENST00000369489ENST00000390683CD58chr1117113525-RAD51Bchr1468758601+0.441858740.55814123
ENST00000457047ENST00000487861CD58chr1117113525-RAD51Bchr1468758601+0.64664750.35335252
ENST00000457047ENST00000471583CD58chr1117113525-RAD51Bchr1468758601+0.600957450.39904255
ENST00000457047ENST00000487270CD58chr1117113525-RAD51Bchr1468758601+0.72461180.27538815
ENST00000457047ENST00000488612CD58chr1117113525-RAD51Bchr1468758601+0.123059030.876941
ENST00000457047ENST00000390683CD58chr1117113525-RAD51Bchr1468758601+0.463095870.53690416
ENST00000369487ENST00000487861CD58chr1117113525-RAD51Bchr1468758601+0.61469280.38530725
ENST00000369487ENST00000471583CD58chr1117113525-RAD51Bchr1468758601+0.60947650.39052346
ENST00000369487ENST00000487270CD58chr1117113525-RAD51Bchr1468758601+0.70213240.29786763
ENST00000369487ENST00000488612CD58chr1117113525-RAD51Bchr1468758601+0.169215650.8307843
ENST00000369487ENST00000390683CD58chr1117113525-RAD51Bchr1468758601+0.441858740.55814123

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Fusion Genomic Features for CD58-RAD51B


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CD58chr1117113524-RAD51Bchr1468758600+4.37E-050.99995625
CD58chr1117113524-RAD51Bchr1468758600+4.37E-050.99995625

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CD58-RAD51B


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:117113525/chr14:68758601)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.RAD51B

O15315

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. {ECO:0000269|PubMed:11751635, ECO:0000269|PubMed:11751636, ECO:0000269|PubMed:11842113, ECO:0000269|PubMed:12441335, ECO:0000269|PubMed:23108668, ECO:0000269|PubMed:23149936}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD58chr1:117113525chr14:68758601ENST00000369489-1630_12123251.0DomainNote=Ig-like
HgeneCD58chr1:117113525chr14:68758601ENST00000457047-1530_12123249.0DomainNote=Ig-like
HgeneCD58chr1:117113525chr14:68758601ENST00000369489-16239_25023251.0Topological domainCytoplasmic
HgeneCD58chr1:117113525chr14:68758601ENST00000369489-1629_21523251.0Topological domainExtracellular
HgeneCD58chr1:117113525chr14:68758601ENST00000457047-15239_25023249.0Topological domainCytoplasmic
HgeneCD58chr1:117113525chr14:68758601ENST00000457047-1529_21523249.0Topological domainExtracellular
HgeneCD58chr1:117113525chr14:68758601ENST00000369489-16216_23823251.0TransmembraneHelical
HgeneCD58chr1:117113525chr14:68758601ENST00000457047-15216_23823249.0TransmembraneHelical
TgeneRAD51Bchr1:117113525chr14:68758601ENST00000390683510108_115252367.0Nucleotide bindingATP
TgeneRAD51Bchr1:117113525chr14:68758601ENST00000471583611108_115252351.0Nucleotide bindingATP
TgeneRAD51Bchr1:117113525chr14:68758601ENST00000487270611108_115252385.0Nucleotide bindingATP
TgeneRAD51Bchr1:117113525chr14:68758601ENST00000488612612108_115252495.6666666666667Nucleotide bindingATP


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Fusion Gene Sequence for CD58-RAD51B


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>14564_14564_1_CD58-RAD51B_CD58_chr1_117113525_ENST00000369487_RAD51B_chr14_68758601_ENST00000390683_length(transcript)=482nt_BP=137nt
GTAGGCGGTGCTTGAACTTAGGGCTGCTTGTGGCTGGGCACTCGCGCAGAGGCCGGCCCGACGAGCCATGGTTGCTGGGAGCGACGCGGG
GCGGGCCCTGGGGGTCCTCAGCGTGGTCTGCCTGCTGCACTGCTTTGGTTATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCC
TGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAG
GAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTC
TGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGAATTTTGGCACATTTGCATATCTGGTTTCTCAA
TCCAGAACAGACTAAAAGAAAATGAGTCCTGA

>14564_14564_1_CD58-RAD51B_CD58_chr1_117113525_ENST00000369487_RAD51B_chr14_68758601_ENST00000390683_length(amino acids)=157AA_BP=42
MNLGLLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTW
SHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWHICISGFSIQNRLKENESX

--------------------------------------------------------------
>14564_14564_2_CD58-RAD51B_CD58_chr1_117113525_ENST00000369487_RAD51B_chr14_68758601_ENST00000471583_length(transcript)=869nt_BP=137nt
GTAGGCGGTGCTTGAACTTAGGGCTGCTTGTGGCTGGGCACTCGCGCAGAGGCCGGCCCGACGAGCCATGGTTGCTGGGAGCGACGCGGG
GCGGGCCCTGGGGGTCCTCAGCGTGGTCTGCCTGCTGCACTGCTTTGGTTATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCC
TGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAG
GAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTC
TGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGGCCAAGAGAAGCCATAGGGATACTGTGACCTTT
GTCTAGAGTTGATGGGGGTGTGATTTGTGAAATAAAACAGGACCGTACTGCTTGGAAGAAGGAAACGGAAGCTGACATAATGGGGATTAA
TTAGTTGATTGCTGTTGAGATGGTAACAGATTTGCTCCTAAACCATTGAGCTAGCGATTTCAGACCTAGCAGGGAAGGTGAAGATGAAGA
AGCCTTTGTTCAGGTCTCTAGATGTGTAGGGCTGAGGGCTTTGCCGCCATGGGATGTCAACAGCCATAATAATAATTTGCACTTATATAG
CACCTTTCAACCAGGCACCTCAAAGCGGTTTAACCACATTAATTAATTAAAGCCCACAATCCTCCTGGGGAGAGGAGGAGGATGACTAAC
AAGATTTGTAATTACAGGAGGGAACATTTCCGAATAAAGTATTGTCTACCAGATAAAAA

>14564_14564_2_CD58-RAD51B_CD58_chr1_117113525_ENST00000369487_RAD51B_chr14_68758601_ENST00000471583_length(amino acids)=140AA_BP=42
MNLGLLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTW
SHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQGQEKP

--------------------------------------------------------------
>14564_14564_3_CD58-RAD51B_CD58_chr1_117113525_ENST00000369487_RAD51B_chr14_68758601_ENST00000487270_length(transcript)=1929nt_BP=137nt
GTAGGCGGTGCTTGAACTTAGGGCTGCTTGTGGCTGGGCACTCGCGCAGAGGCCGGCCCGACGAGCCATGGTTGCTGGGAGCGACGCGGG
GCGGGCCCTGGGGGTCCTCAGCGTGGTCTGCCTGCTGCACTGCTTTGGTTATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCC
TGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAG
GAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTC
TGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGAGACAACATTTTGCTCTGTCACCCAAGCTGAAC
TGAACTGGGCTCCAGAAATCCTCCCACCTCAGCCTCCTGAGCAGCTAGGACTACAGATGTGCCACCATACCCAGCTAATTTTTTAATTTT
TTGTAGAGGTGGGGTCTCATTATGTTGCCCAAGCTGATCTCAAACTCCTGGCTTCAAGAGATCCACCCACCTCAGCCTCCCAAAGCGCTA
GGATTACAAGTATGAGACTTTGCCATTCCAATGAGAATTTTGTCCTTAGCAATCTCATCCAATGGCCACTGGAGATGTGTGTAGGGCCAC
AAGAATGAGAAAGGGGGCAATGGAGTGACAGGTGACCTGCTCAGGTGCCCCTCCCCAGACCAAATGTCCCAGGCACACAGCCCATGCCCT
CCACCATGGAGTACATTTTCTCCCTGGCTTGCTGCTGAGCTAAAGGACCAGGGACGTGGAAACAGGAGGTGAACTAAGGCACCCCGCCAC
CCACTGTGGCAGCTTGAATTTCTTGAGGCTGAGACAAACTAGGATCCAGTAGCCTAGATTTTGCCCCAGTTTCTCCACTGAGTATTTACT
CAGTGCTCCTGAGCCGATGCCTTCCCCTCTGCCTAGATGAACCACAGCATTTTGGTAAATGCCTCAGCATGTTAGGAGCGCTGGAACGTT
TATTCTCTTCCCTCCCAATTATCCACTCTAATGGAGCAGAACACTTACATGGAAAATCCTAAACATGGAAGATGATTTAAAAATGATTCA
CCCTGGAATACATGCTTCCAGTTGCTTCTACAGGTTTACCTTGCTAAAGGCATTTCGCTTCCTTTGCTGTTACAATAAGCTTGCCTGCCT
TGAAGAAAAGAAGACCAGGGCCAAAGGGAAATCAGTCAAGGGAGCCTGTTTTGTCTGAAATAATGCATCCATGAACAAATGAATTGAGTA
TAACTGTCTTTTTACATCAGTGTTTCTGTGGAATTAAGAGAACATCCAAGGCCACTCCTAGCTTGAGTAGATTAAATTTGTCCTTGTGTT
TGGAGCAAGGGTTGTGAAGTCTGTCTGGCCCATCAAATGACCAATGGCTTTTAAGGAAGGACTAAGTGACTTATGACCAGAACAAGGGAG
CAGCCTGAGTCAGTCTCCCCAATGTCTACATTGTGTTATTTATACTAGCAAAAAAATAGACACAACTAAATGTTCGACCATATGGTATTG
GTTAAATTAACATCTATACGATGGAATACTAGATGGTCATTAAAATTATGTGTCAGAAGAAGGCTTAATCTCATGGGAAAGTGTTCACAC
CATATTATTAAAGAGAAAAAACAGATTATAAAGCAATATGCATACAATGTAGTAGTTCTGTAAGAAAAAAGTATTATGTGCATTTTAACT
GGAAAAATATGTATAAAAATGTTAACAGTGCAATCTCTGGGCAATAAGATTATACTTGACTTTTATTTCTTTTTTGGAATTGTCTTTTTT
TTTTTTTTTTCAAGTTTCCTCCCATTAACATGCATGTTC

>14564_14564_3_CD58-RAD51B_CD58_chr1_117113525_ENST00000369487_RAD51B_chr14_68758601_ENST00000487270_length(amino acids)=174AA_BP=42
MNLGLLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTW
SHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQETTFCSVTQAELNWAPEILPPQPPEQLGLQMCHHTQLIF

--------------------------------------------------------------
>14564_14564_4_CD58-RAD51B_CD58_chr1_117113525_ENST00000369487_RAD51B_chr14_68758601_ENST00000487861_length(transcript)=977nt_BP=137nt
GTAGGCGGTGCTTGAACTTAGGGCTGCTTGTGGCTGGGCACTCGCGCAGAGGCCGGCCCGACGAGCCATGGTTGCTGGGAGCGACGCGGG
GCGGGCCCTGGGGGTCCTCAGCGTGGTCTGCCTGCTGCACTGCTTTGGTTATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCC
TGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAG
GAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTC
TGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGTTGTTAGAACTGTGGCCAGAGTCAGCCCCAGGT
CAGAATGCTGGTCAGCAGCAGACTCACATCCCAGCCCTACCTTCCTGATACCTGATGTGGTGCTCAGAAAAACAAGGAATCCCAGGCTGT
TACCCAGTGTCTCCATGTGCCCTCCACAGATGCACTCAACTGTCCTCTCTTCTGCTCTTCCTCCTACAAACTGGGCAACTGGAATCAGAA
CAGAGACTTTGGATGAGCATCCAGTGTAACCCAGCCTAGTTTTTCACCACGACTTCCAGATCTACATTTAACATCCGACAGCAACTATAA
TTCTACTTTCTGAACCTCCAGGGAAGTTGCTTCCTTGTCCCTTTCAGCAAAGGATGTCATGGTTTTACAATGTCTCCAGTGAAAAAGTTC
TTCTTCTCTACATCTTCCTCCCACTCCTACAACCCTTGATCCCCACGTGAGATCTCATTTCCTCCAGCTGGGTCTTCTGCAGAGTGATTA
GAGCTTCTGCCCTCCTTGCAGCATCTCTATTGTAAAAGGATTGCTGAAGCTTATTAAGCCTTGCAGCTCCTAGGAGG

>14564_14564_4_CD58-RAD51B_CD58_chr1_117113525_ENST00000369487_RAD51B_chr14_68758601_ENST00000487861_length(amino acids)=215AA_BP=42
MNLGLLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTW
SHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPRSECWSAADSHPSPTFLIPDVVLRKTRNPRLLPSV
SMCPPQMHSTVLSSALPPTNWATGIRTETLDEHPV

--------------------------------------------------------------
>14564_14564_5_CD58-RAD51B_CD58_chr1_117113525_ENST00000369487_RAD51B_chr14_68758601_ENST00000488612_length(transcript)=904nt_BP=137nt
GTAGGCGGTGCTTGAACTTAGGGCTGCTTGTGGCTGGGCACTCGCGCAGAGGCCGGCCCGACGAGCCATGGTTGCTGGGAGCGACGCGGG
GCGGGCCCTGGGGGTCCTCAGCGTGGTCTGCCTGCTGCACTGCTTTGGTTATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCC
TGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAG
GAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTC
TGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGAATTTTGGCACATTTGCATATCTGGTTTCTCAA
TCCAGAACAGACTAAAAGAAAATGAGTCCTGAGATTGCTACAGATGAGACCCACCCATCGGAGCCAGGCTTTGAAGGAACTGACCGCAGT
GTGCATGAGGAAGTACTTCACGGTGATGACCCTCGCCACCCTCTCAGGAAAACACAGTGACCTCTCCCCCAACATCCCCTTCCCACTCCC
AGGTCCCCCGGCAAAGGCAGAAGAACCAAGCAAGCCTTTCCACCAAAGCAGCCATGAACCCCATTCTCATCCTTTCCAAGAACTCTCTGC
TATACCAGATAGGGGTTTGGGGTTCTGTTTTCCATTTTTTAAAAAAATCATTTCAAGACTCTTGAACAGTGTGTCGGTTTACACTATTCT
ATCTTCTTAAGCCACCATATCAACATATTCACTCTGCTTCCTTTCTTTTCATTTGGCAGATGCCACACTTTTAATGGCAGCAATAAAAGG
TGTT

>14564_14564_5_CD58-RAD51B_CD58_chr1_117113525_ENST00000369487_RAD51B_chr14_68758601_ENST00000488612_length(amino acids)=156AA_BP=42
MNLGLLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTW
SHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWHICISGFSIQNRLKENES

--------------------------------------------------------------
>14564_14564_6_CD58-RAD51B_CD58_chr1_117113525_ENST00000369489_RAD51B_chr14_68758601_ENST00000390683_length(transcript)=482nt_BP=137nt
GTAGGCGGTGCTTGAACTTAGGGCTGCTTGTGGCTGGGCACTCGCGCAGAGGCCGGCCCGACGAGCCATGGTTGCTGGGAGCGACGCGGG
GCGGGCCCTGGGGGTCCTCAGCGTGGTCTGCCTGCTGCACTGCTTTGGTTATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCC
TGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAG
GAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTC
TGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGAATTTTGGCACATTTGCATATCTGGTTTCTCAA
TCCAGAACAGACTAAAAGAAAATGAGTCCTGA

>14564_14564_6_CD58-RAD51B_CD58_chr1_117113525_ENST00000369489_RAD51B_chr14_68758601_ENST00000390683_length(amino acids)=157AA_BP=42
MNLGLLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTW
SHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWHICISGFSIQNRLKENESX

--------------------------------------------------------------
>14564_14564_7_CD58-RAD51B_CD58_chr1_117113525_ENST00000369489_RAD51B_chr14_68758601_ENST00000471583_length(transcript)=869nt_BP=137nt
GTAGGCGGTGCTTGAACTTAGGGCTGCTTGTGGCTGGGCACTCGCGCAGAGGCCGGCCCGACGAGCCATGGTTGCTGGGAGCGACGCGGG
GCGGGCCCTGGGGGTCCTCAGCGTGGTCTGCCTGCTGCACTGCTTTGGTTATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCC
TGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAG
GAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTC
TGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGGCCAAGAGAAGCCATAGGGATACTGTGACCTTT
GTCTAGAGTTGATGGGGGTGTGATTTGTGAAATAAAACAGGACCGTACTGCTTGGAAGAAGGAAACGGAAGCTGACATAATGGGGATTAA
TTAGTTGATTGCTGTTGAGATGGTAACAGATTTGCTCCTAAACCATTGAGCTAGCGATTTCAGACCTAGCAGGGAAGGTGAAGATGAAGA
AGCCTTTGTTCAGGTCTCTAGATGTGTAGGGCTGAGGGCTTTGCCGCCATGGGATGTCAACAGCCATAATAATAATTTGCACTTATATAG
CACCTTTCAACCAGGCACCTCAAAGCGGTTTAACCACATTAATTAATTAAAGCCCACAATCCTCCTGGGGAGAGGAGGAGGATGACTAAC
AAGATTTGTAATTACAGGAGGGAACATTTCCGAATAAAGTATTGTCTACCAGATAAAAA

>14564_14564_7_CD58-RAD51B_CD58_chr1_117113525_ENST00000369489_RAD51B_chr14_68758601_ENST00000471583_length(amino acids)=140AA_BP=42
MNLGLLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTW
SHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQGQEKP

--------------------------------------------------------------
>14564_14564_8_CD58-RAD51B_CD58_chr1_117113525_ENST00000369489_RAD51B_chr14_68758601_ENST00000487270_length(transcript)=1929nt_BP=137nt
GTAGGCGGTGCTTGAACTTAGGGCTGCTTGTGGCTGGGCACTCGCGCAGAGGCCGGCCCGACGAGCCATGGTTGCTGGGAGCGACGCGGG
GCGGGCCCTGGGGGTCCTCAGCGTGGTCTGCCTGCTGCACTGCTTTGGTTATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCC
TGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAG
GAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTC
TGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGAGACAACATTTTGCTCTGTCACCCAAGCTGAAC
TGAACTGGGCTCCAGAAATCCTCCCACCTCAGCCTCCTGAGCAGCTAGGACTACAGATGTGCCACCATACCCAGCTAATTTTTTAATTTT
TTGTAGAGGTGGGGTCTCATTATGTTGCCCAAGCTGATCTCAAACTCCTGGCTTCAAGAGATCCACCCACCTCAGCCTCCCAAAGCGCTA
GGATTACAAGTATGAGACTTTGCCATTCCAATGAGAATTTTGTCCTTAGCAATCTCATCCAATGGCCACTGGAGATGTGTGTAGGGCCAC
AAGAATGAGAAAGGGGGCAATGGAGTGACAGGTGACCTGCTCAGGTGCCCCTCCCCAGACCAAATGTCCCAGGCACACAGCCCATGCCCT
CCACCATGGAGTACATTTTCTCCCTGGCTTGCTGCTGAGCTAAAGGACCAGGGACGTGGAAACAGGAGGTGAACTAAGGCACCCCGCCAC
CCACTGTGGCAGCTTGAATTTCTTGAGGCTGAGACAAACTAGGATCCAGTAGCCTAGATTTTGCCCCAGTTTCTCCACTGAGTATTTACT
CAGTGCTCCTGAGCCGATGCCTTCCCCTCTGCCTAGATGAACCACAGCATTTTGGTAAATGCCTCAGCATGTTAGGAGCGCTGGAACGTT
TATTCTCTTCCCTCCCAATTATCCACTCTAATGGAGCAGAACACTTACATGGAAAATCCTAAACATGGAAGATGATTTAAAAATGATTCA
CCCTGGAATACATGCTTCCAGTTGCTTCTACAGGTTTACCTTGCTAAAGGCATTTCGCTTCCTTTGCTGTTACAATAAGCTTGCCTGCCT
TGAAGAAAAGAAGACCAGGGCCAAAGGGAAATCAGTCAAGGGAGCCTGTTTTGTCTGAAATAATGCATCCATGAACAAATGAATTGAGTA
TAACTGTCTTTTTACATCAGTGTTTCTGTGGAATTAAGAGAACATCCAAGGCCACTCCTAGCTTGAGTAGATTAAATTTGTCCTTGTGTT
TGGAGCAAGGGTTGTGAAGTCTGTCTGGCCCATCAAATGACCAATGGCTTTTAAGGAAGGACTAAGTGACTTATGACCAGAACAAGGGAG
CAGCCTGAGTCAGTCTCCCCAATGTCTACATTGTGTTATTTATACTAGCAAAAAAATAGACACAACTAAATGTTCGACCATATGGTATTG
GTTAAATTAACATCTATACGATGGAATACTAGATGGTCATTAAAATTATGTGTCAGAAGAAGGCTTAATCTCATGGGAAAGTGTTCACAC
CATATTATTAAAGAGAAAAAACAGATTATAAAGCAATATGCATACAATGTAGTAGTTCTGTAAGAAAAAAGTATTATGTGCATTTTAACT
GGAAAAATATGTATAAAAATGTTAACAGTGCAATCTCTGGGCAATAAGATTATACTTGACTTTTATTTCTTTTTTGGAATTGTCTTTTTT
TTTTTTTTTTCAAGTTTCCTCCCATTAACATGCATGTTC

>14564_14564_8_CD58-RAD51B_CD58_chr1_117113525_ENST00000369489_RAD51B_chr14_68758601_ENST00000487270_length(amino acids)=174AA_BP=42
MNLGLLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTW
SHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQETTFCSVTQAELNWAPEILPPQPPEQLGLQMCHHTQLIF

--------------------------------------------------------------
>14564_14564_9_CD58-RAD51B_CD58_chr1_117113525_ENST00000369489_RAD51B_chr14_68758601_ENST00000487861_length(transcript)=977nt_BP=137nt
GTAGGCGGTGCTTGAACTTAGGGCTGCTTGTGGCTGGGCACTCGCGCAGAGGCCGGCCCGACGAGCCATGGTTGCTGGGAGCGACGCGGG
GCGGGCCCTGGGGGTCCTCAGCGTGGTCTGCCTGCTGCACTGCTTTGGTTATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCC
TGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAG
GAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTC
TGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGTTGTTAGAACTGTGGCCAGAGTCAGCCCCAGGT
CAGAATGCTGGTCAGCAGCAGACTCACATCCCAGCCCTACCTTCCTGATACCTGATGTGGTGCTCAGAAAAACAAGGAATCCCAGGCTGT
TACCCAGTGTCTCCATGTGCCCTCCACAGATGCACTCAACTGTCCTCTCTTCTGCTCTTCCTCCTACAAACTGGGCAACTGGAATCAGAA
CAGAGACTTTGGATGAGCATCCAGTGTAACCCAGCCTAGTTTTTCACCACGACTTCCAGATCTACATTTAACATCCGACAGCAACTATAA
TTCTACTTTCTGAACCTCCAGGGAAGTTGCTTCCTTGTCCCTTTCAGCAAAGGATGTCATGGTTTTACAATGTCTCCAGTGAAAAAGTTC
TTCTTCTCTACATCTTCCTCCCACTCCTACAACCCTTGATCCCCACGTGAGATCTCATTTCCTCCAGCTGGGTCTTCTGCAGAGTGATTA
GAGCTTCTGCCCTCCTTGCAGCATCTCTATTGTAAAAGGATTGCTGAAGCTTATTAAGCCTTGCAGCTCCTAGGAGG

>14564_14564_9_CD58-RAD51B_CD58_chr1_117113525_ENST00000369489_RAD51B_chr14_68758601_ENST00000487861_length(amino acids)=215AA_BP=42
MNLGLLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTW
SHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPRSECWSAADSHPSPTFLIPDVVLRKTRNPRLLPSV
SMCPPQMHSTVLSSALPPTNWATGIRTETLDEHPV

--------------------------------------------------------------
>14564_14564_10_CD58-RAD51B_CD58_chr1_117113525_ENST00000369489_RAD51B_chr14_68758601_ENST00000488612_length(transcript)=904nt_BP=137nt
GTAGGCGGTGCTTGAACTTAGGGCTGCTTGTGGCTGGGCACTCGCGCAGAGGCCGGCCCGACGAGCCATGGTTGCTGGGAGCGACGCGGG
GCGGGCCCTGGGGGTCCTCAGCGTGGTCTGCCTGCTGCACTGCTTTGGTTATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCC
TGGCTTCTCAGGCAGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAG
GAAATACCTGGAGTCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTC
TGGCTCCCTTCACCTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGAATTTTGGCACATTTGCATATCTGGTTTCTCAA
TCCAGAACAGACTAAAAGAAAATGAGTCCTGAGATTGCTACAGATGAGACCCACCCATCGGAGCCAGGCTTTGAAGGAACTGACCGCAGT
GTGCATGAGGAAGTACTTCACGGTGATGACCCTCGCCACCCTCTCAGGAAAACACAGTGACCTCTCCCCCAACATCCCCTTCCCACTCCC
AGGTCCCCCGGCAAAGGCAGAAGAACCAAGCAAGCCTTTCCACCAAAGCAGCCATGAACCCCATTCTCATCCTTTCCAAGAACTCTCTGC
TATACCAGATAGGGGTTTGGGGTTCTGTTTTCCATTTTTTAAAAAAATCATTTCAAGACTCTTGAACAGTGTGTCGGTTTACACTATTCT
ATCTTCTTAAGCCACCATATCAACATATTCACTCTGCTTCCTTTCTTTTCATTTGGCAGATGCCACACTTTTAATGGCAGCAATAAAAGG
TGTT

>14564_14564_10_CD58-RAD51B_CD58_chr1_117113525_ENST00000369489_RAD51B_chr14_68758601_ENST00000488612_length(amino acids)=156AA_BP=42
MNLGLLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTW
SHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWHICISGFSIQNRLKENES

--------------------------------------------------------------
>14564_14564_11_CD58-RAD51B_CD58_chr1_117113525_ENST00000457047_RAD51B_chr14_68758601_ENST00000390683_length(transcript)=469nt_BP=124nt
GAACTTAGGGCTGCTTGTGGCTGGGCACTCGCGCAGAGGCCGGCCCGACGAGCCATGGTTGCTGGGAGCGACGCGGGGCGGGCCCTGGGG
GTCCTCAGCGTGGTCTGCCTGCTGCACTGCTTTGGTTATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCCTGGCTTCTCAGGC
AGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAGGAAATACCTGGAG
TCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTCTGGCTCCCTTCAC
CTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGAATTTTGGCACATTTGCATATCTGGTTTCTCAATCCAGAACAGACT
AAAAGAAAATGAGTCCTGA

>14564_14564_11_CD58-RAD51B_CD58_chr1_117113525_ENST00000457047_RAD51B_chr14_68758601_ENST00000390683_length(amino acids)=153AA_BP=38
MLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSV
NTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWHICISGFSIQNRLKENESX

--------------------------------------------------------------
>14564_14564_12_CD58-RAD51B_CD58_chr1_117113525_ENST00000457047_RAD51B_chr14_68758601_ENST00000471583_length(transcript)=856nt_BP=124nt
GAACTTAGGGCTGCTTGTGGCTGGGCACTCGCGCAGAGGCCGGCCCGACGAGCCATGGTTGCTGGGAGCGACGCGGGGCGGGCCCTGGGG
GTCCTCAGCGTGGTCTGCCTGCTGCACTGCTTTGGTTATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCCTGGCTTCTCAGGC
AGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAGGAAATACCTGGAG
TCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTCTGGCTCCCTTCAC
CTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGGCCAAGAGAAGCCATAGGGATACTGTGACCTTTGTCTAGAGTTGAT
GGGGGTGTGATTTGTGAAATAAAACAGGACCGTACTGCTTGGAAGAAGGAAACGGAAGCTGACATAATGGGGATTAATTAGTTGATTGCT
GTTGAGATGGTAACAGATTTGCTCCTAAACCATTGAGCTAGCGATTTCAGACCTAGCAGGGAAGGTGAAGATGAAGAAGCCTTTGTTCAG
GTCTCTAGATGTGTAGGGCTGAGGGCTTTGCCGCCATGGGATGTCAACAGCCATAATAATAATTTGCACTTATATAGCACCTTTCAACCA
GGCACCTCAAAGCGGTTTAACCACATTAATTAATTAAAGCCCACAATCCTCCTGGGGAGAGGAGGAGGATGACTAACAAGATTTGTAATT
ACAGGAGGGAACATTTCCGAATAAAGTATTGTCTACCAGATAAAAA

>14564_14564_12_CD58-RAD51B_CD58_chr1_117113525_ENST00000457047_RAD51B_chr14_68758601_ENST00000471583_length(amino acids)=136AA_BP=38
MLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSV
NTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQGQEKP

--------------------------------------------------------------
>14564_14564_13_CD58-RAD51B_CD58_chr1_117113525_ENST00000457047_RAD51B_chr14_68758601_ENST00000487270_length(transcript)=1916nt_BP=124nt
GAACTTAGGGCTGCTTGTGGCTGGGCACTCGCGCAGAGGCCGGCCCGACGAGCCATGGTTGCTGGGAGCGACGCGGGGCGGGCCCTGGGG
GTCCTCAGCGTGGTCTGCCTGCTGCACTGCTTTGGTTATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCCTGGCTTCTCAGGC
AGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAGGAAATACCTGGAG
TCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTCTGGCTCCCTTCAC
CTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGAGACAACATTTTGCTCTGTCACCCAAGCTGAACTGAACTGGGCTCC
AGAAATCCTCCCACCTCAGCCTCCTGAGCAGCTAGGACTACAGATGTGCCACCATACCCAGCTAATTTTTTAATTTTTTGTAGAGGTGGG
GTCTCATTATGTTGCCCAAGCTGATCTCAAACTCCTGGCTTCAAGAGATCCACCCACCTCAGCCTCCCAAAGCGCTAGGATTACAAGTAT
GAGACTTTGCCATTCCAATGAGAATTTTGTCCTTAGCAATCTCATCCAATGGCCACTGGAGATGTGTGTAGGGCCACAAGAATGAGAAAG
GGGGCAATGGAGTGACAGGTGACCTGCTCAGGTGCCCCTCCCCAGACCAAATGTCCCAGGCACACAGCCCATGCCCTCCACCATGGAGTA
CATTTTCTCCCTGGCTTGCTGCTGAGCTAAAGGACCAGGGACGTGGAAACAGGAGGTGAACTAAGGCACCCCGCCACCCACTGTGGCAGC
TTGAATTTCTTGAGGCTGAGACAAACTAGGATCCAGTAGCCTAGATTTTGCCCCAGTTTCTCCACTGAGTATTTACTCAGTGCTCCTGAG
CCGATGCCTTCCCCTCTGCCTAGATGAACCACAGCATTTTGGTAAATGCCTCAGCATGTTAGGAGCGCTGGAACGTTTATTCTCTTCCCT
CCCAATTATCCACTCTAATGGAGCAGAACACTTACATGGAAAATCCTAAACATGGAAGATGATTTAAAAATGATTCACCCTGGAATACAT
GCTTCCAGTTGCTTCTACAGGTTTACCTTGCTAAAGGCATTTCGCTTCCTTTGCTGTTACAATAAGCTTGCCTGCCTTGAAGAAAAGAAG
ACCAGGGCCAAAGGGAAATCAGTCAAGGGAGCCTGTTTTGTCTGAAATAATGCATCCATGAACAAATGAATTGAGTATAACTGTCTTTTT
ACATCAGTGTTTCTGTGGAATTAAGAGAACATCCAAGGCCACTCCTAGCTTGAGTAGATTAAATTTGTCCTTGTGTTTGGAGCAAGGGTT
GTGAAGTCTGTCTGGCCCATCAAATGACCAATGGCTTTTAAGGAAGGACTAAGTGACTTATGACCAGAACAAGGGAGCAGCCTGAGTCAG
TCTCCCCAATGTCTACATTGTGTTATTTATACTAGCAAAAAAATAGACACAACTAAATGTTCGACCATATGGTATTGGTTAAATTAACAT
CTATACGATGGAATACTAGATGGTCATTAAAATTATGTGTCAGAAGAAGGCTTAATCTCATGGGAAAGTGTTCACACCATATTATTAAAG
AGAAAAAACAGATTATAAAGCAATATGCATACAATGTAGTAGTTCTGTAAGAAAAAAGTATTATGTGCATTTTAACTGGAAAAATATGTA
TAAAAATGTTAACAGTGCAATCTCTGGGCAATAAGATTATACTTGACTTTTATTTCTTTTTTGGAATTGTCTTTTTTTTTTTTTTTTCAA
GTTTCCTCCCATTAACATGCATGTTC

>14564_14564_13_CD58-RAD51B_CD58_chr1_117113525_ENST00000457047_RAD51B_chr14_68758601_ENST00000487270_length(amino acids)=170AA_BP=38
MLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSV
NTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQETTFCSVTQAELNWAPEILPPQPPEQLGLQMCHHTQLIF

--------------------------------------------------------------
>14564_14564_14_CD58-RAD51B_CD58_chr1_117113525_ENST00000457047_RAD51B_chr14_68758601_ENST00000487861_length(transcript)=964nt_BP=124nt
GAACTTAGGGCTGCTTGTGGCTGGGCACTCGCGCAGAGGCCGGCCCGACGAGCCATGGTTGCTGGGAGCGACGCGGGGCGGGCCCTGGGG
GTCCTCAGCGTGGTCTGCCTGCTGCACTGCTTTGGTTATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCCTGGCTTCTCAGGC
AGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAGGAAATACCTGGAG
TCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTCTGGCTCCCTTCAC
CTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGTTGTTAGAACTGTGGCCAGAGTCAGCCCCAGGTCAGAATGCTGGTC
AGCAGCAGACTCACATCCCAGCCCTACCTTCCTGATACCTGATGTGGTGCTCAGAAAAACAAGGAATCCCAGGCTGTTACCCAGTGTCTC
CATGTGCCCTCCACAGATGCACTCAACTGTCCTCTCTTCTGCTCTTCCTCCTACAAACTGGGCAACTGGAATCAGAACAGAGACTTTGGA
TGAGCATCCAGTGTAACCCAGCCTAGTTTTTCACCACGACTTCCAGATCTACATTTAACATCCGACAGCAACTATAATTCTACTTTCTGA
ACCTCCAGGGAAGTTGCTTCCTTGTCCCTTTCAGCAAAGGATGTCATGGTTTTACAATGTCTCCAGTGAAAAAGTTCTTCTTCTCTACAT
CTTCCTCCCACTCCTACAACCCTTGATCCCCACGTGAGATCTCATTTCCTCCAGCTGGGTCTTCTGCAGAGTGATTAGAGCTTCTGCCCT
CCTTGCAGCATCTCTATTGTAAAAGGATTGCTGAAGCTTATTAAGCCTTGCAGCTCCTAGGAGG

>14564_14564_14_CD58-RAD51B_CD58_chr1_117113525_ENST00000457047_RAD51B_chr14_68758601_ENST00000487861_length(amino acids)=211AA_BP=38
MLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSV
NTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPRSECWSAADSHPSPTFLIPDVVLRKTRNPRLLPSVSMCP
PQMHSTVLSSALPPTNWATGIRTETLDEHPV

--------------------------------------------------------------
>14564_14564_15_CD58-RAD51B_CD58_chr1_117113525_ENST00000457047_RAD51B_chr14_68758601_ENST00000488612_length(transcript)=891nt_BP=124nt
GAACTTAGGGCTGCTTGTGGCTGGGCACTCGCGCAGAGGCCGGCCCGACGAGCCATGGTTGCTGGGAGCGACGCGGGGCGGGCCCTGGGG
GTCCTCAGCGTGGTCTGCCTGCTGCACTGCTTTGGTTATCTTGACGAATCAGATTACAACCCATCTGAGTGGAGCCCTGGCTTCTCAGGC
AGACCTGGTGTCTCCAGCTGATGATTTGTCCCTGTCTGAAGGCACTTCTGGATCCAGCTGTGTGATAGCCGCACTAGGAAATACCTGGAG
TCACAGTGTGAATACCCGGCTGATCCTCCAGTACCTTGATTCAGAGAGAAGACAGATTCTTATTGCCAAGTCCCCTCTGGCTCCCTTCAC
CTCATTTGTCTACACCATCAAGGAGGAAGGCCTGGTTCTTCAAGAATTTTGGCACATTTGCATATCTGGTTTCTCAATCCAGAACAGACT
AAAAGAAAATGAGTCCTGAGATTGCTACAGATGAGACCCACCCATCGGAGCCAGGCTTTGAAGGAACTGACCGCAGTGTGCATGAGGAAG
TACTTCACGGTGATGACCCTCGCCACCCTCTCAGGAAAACACAGTGACCTCTCCCCCAACATCCCCTTCCCACTCCCAGGTCCCCCGGCA
AAGGCAGAAGAACCAAGCAAGCCTTTCCACCAAAGCAGCCATGAACCCCATTCTCATCCTTTCCAAGAACTCTCTGCTATACCAGATAGG
GGTTTGGGGTTCTGTTTTCCATTTTTTAAAAAAATCATTTCAAGACTCTTGAACAGTGTGTCGGTTTACACTATTCTATCTTCTTAAGCC
ACCATATCAACATATTCACTCTGCTTCCTTTCTTTTCATTTGGCAGATGCCACACTTTTAATGGCAGCAATAAAAGGTGTT

>14564_14564_15_CD58-RAD51B_CD58_chr1_117113525_ENST00000457047_RAD51B_chr14_68758601_ENST00000488612_length(amino acids)=152AA_BP=38
MLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSV
NTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWHICISGFSIQNRLKENES

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CD58-RAD51B


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneRAD51Bchr1:117113525chr14:68758601ENST000003906835101_75252.0367.0RAD51C
TgeneRAD51Bchr1:117113525chr14:68758601ENST000004715836111_75252.0351.0RAD51C
TgeneRAD51Bchr1:117113525chr14:68758601ENST000004872706111_75252.0385.0RAD51C
TgeneRAD51Bchr1:117113525chr14:68758601ENST000004886126121_75252.0495.6666666666667RAD51C


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CD58-RAD51B


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CD58-RAD51B


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCD58C0026769Multiple Sclerosis2CTD_human
HgeneCD58C0751324Multiple Sclerosis, Acute Fulminating2CTD_human
HgeneCD58C0079774Peripheral T-Cell Lymphoma1CTD_human
TgeneC0006142Malignant neoplasm of breast1CTD_human
TgeneC0013146Drug abuse1CTD_human
TgeneC0013170Drug habituation1CTD_human
TgeneC0013222Drug Use Disorders1CTD_human
TgeneC0029231Organic Mental Disorders, Substance-Induced1CTD_human
TgeneC0038580Substance Dependence1CTD_human
TgeneC0038586Substance Use Disorders1CTD_human
TgeneC0236969Substance-Related Disorders1CTD_human
TgeneC0238033Carcinoma of Male Breast1CTD_human
TgeneC0242788Breast Neoplasms, Male1CTD_human
TgeneC0678222Breast Carcinoma1CTD_human
TgeneC0740858Substance abuse problem1CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC1510472Drug Dependence1CTD_human
TgeneC4316881Prescription Drug Abuse1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human