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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CD58-CAPZA1 (FusionGDB2 ID:HG965TG829)

Fusion Gene Summary for CD58-CAPZA1

check button Fusion gene summary
Fusion gene informationFusion gene name: CD58-CAPZA1
Fusion gene ID: hg965tg829
HgeneTgene
Gene symbol

CD58

CAPZA1

Gene ID

965

829

Gene nameCD58 moleculecapping actin protein of muscle Z-line subunit alpha 1
SynonymsLFA-3|LFA3|ag3CAPPA1|CAPZ|CAZ1
Cytomap('CD58')('CAPZA1')

1p13.1

1p13.2

Type of geneprotein-codingprotein-coding
Descriptionlymphocyte function-associated antigen 3CD58 antigen, (lymphocyte function-associated antigen 3)surface glycoprotein LFA-3F-actin-capping protein subunit alpha-1Cap ZcapZ alpha-1capping actin protein of muscle Z-line alpha subunit 1capping protein (actin filament) muscle Z-line, alpha 1
Modification date2020031320200327
UniProtAcc.

P52907

Ensembl transtripts involved in fusion geneENST00000369487, ENST00000369489, 
ENST00000457047, 
Fusion gene scores* DoF score6 X 5 X 5=15010 X 11 X 5=550
# samples 610
** MAII scorelog2(6/150*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(10/550*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CD58 [Title/Abstract] AND CAPZA1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCD58(117113524)-CAPZA1(113189831), # samples:1
Anticipated loss of major functional domain due to fusion event.CD58-CAPZA1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CD58-CAPZA1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD58

GO:0034113

heterotypic cell-cell adhesion

15345303

HgeneCD58

GO:0071346

cellular response to interferon-gamma

19109405

HgeneCD58

GO:0071356

cellular response to tumor necrosis factor

19109405


check buttonFusion gene breakpoints across CD58 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across CAPZA1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-Cancer2397NCD58chr1

117113524

-CAPZA1chr1

113189831

+


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Fusion Gene ORF analysis for CD58-CAPZA1

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000369487ENST00000476936CD58chr1

117113524

-CAPZA1chr1

113189831

+
5CDS-3UTRENST00000369489ENST00000476936CD58chr1

117113524

-CAPZA1chr1

113189831

+
5CDS-3UTRENST00000457047ENST00000476936CD58chr1

117113524

-CAPZA1chr1

113189831

+
In-frameENST00000369487ENST00000263168CD58chr1

117113524

-CAPZA1chr1

113189831

+
In-frameENST00000369489ENST00000263168CD58chr1

117113524

-CAPZA1chr1

113189831

+
In-frameENST00000457047ENST00000263168CD58chr1

117113524

-CAPZA1chr1

113189831

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000369489CD58chr1117113524-ENST00000263168CAPZA1chr1113189831+244613711958315
ENST00000457047CD58chr1117113524-ENST00000263168CAPZA1chr1113189831+243312410945311
ENST00000369487CD58chr1117113524-ENST00000263168CAPZA1chr1113189831+244613711958315

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000369489ENST00000263168CD58chr1117113524-CAPZA1chr1113189831+0.0004288630.99957114
ENST00000457047ENST00000263168CD58chr1117113524-CAPZA1chr1113189831+0.0004779540.9995221
ENST00000369487ENST00000263168CD58chr1117113524-CAPZA1chr1113189831+0.0004288630.99957114

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Fusion Genomic Features for CD58-CAPZA1


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CD58chr1117113524-CAPZA1chr1113189831+0.0027275820.99727243
CD58chr1117113524-CAPZA1chr1113189831+0.0027275820.99727243

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CD58-CAPZA1


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:117113524/chr1:113189831)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CAPZA1

P52907

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. May play a role in the formation of epithelial cell junctions. {ECO:0000269|PubMed:22891260}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCD58chr1:117113524chr1:113189831ENST00000369489-1630_12123251.0DomainNote=Ig-like
HgeneCD58chr1:117113524chr1:113189831ENST00000457047-1530_12123249.0DomainNote=Ig-like
HgeneCD58chr1:117113524chr1:113189831ENST00000369489-16239_25023251.0Topological domainCytoplasmic
HgeneCD58chr1:117113524chr1:113189831ENST00000369489-1629_21523251.0Topological domainExtracellular
HgeneCD58chr1:117113524chr1:113189831ENST00000457047-15239_25023249.0Topological domainCytoplasmic
HgeneCD58chr1:117113524chr1:113189831ENST00000457047-1529_21523249.0Topological domainExtracellular
HgeneCD58chr1:117113524chr1:113189831ENST00000369489-16216_23823251.0TransmembraneHelical
HgeneCD58chr1:117113524chr1:113189831ENST00000457047-15216_23823249.0TransmembraneHelical


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Fusion Gene Sequence for CD58-CAPZA1


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>14559_14559_1_CD58-CAPZA1_CD58_chr1_117113524_ENST00000369487_CAPZA1_chr1_113189831_ENST00000263168_length(transcript)=2446nt_BP=137nt
GTAGGCGGTGCTTGAACTTAGGGCTGCTTGTGGCTGGGCACTCGCGCAGAGGCCGGCCCGACGAGCCATGGTTGCTGGGAGCGACGCGGG
GCGGGCCCTGGGGGTCCTCAGCGTGGTCTGCCTGCTGCACTGCTTTGGTACGCATAGCTGCTAAATTCATCACTCATGCACCCCCAGGGG
AATTTAATGAAGTATTCAATGACGTTCGGCTACTACTTAATAATGACAATCTCCTCAGGGAAGGGGCAGCACATGCATTTGCCCAGTATA
ACATGGATCAGTTCACGCCTGTGAAGATAGAAGGATATGAAGATCAGGTCTTAATTACAGAGCACGGTGACCTGGGTAATAGCAGATTTT
TAGATCCAAGAAACAAAATTTCCTTTAAATTTGACCACTTACGGAAAGAAGCAAGTGACCCCCAGCCAGAAGAAGCAGATGGAGGTCTGA
AGTCTTGGAGAGAATCCTGTGACAGTGCTTTAAGAGCCTATGTGAAAGACCATTATTCCAACGGCTTCTGTACTGTTTATGCTAAAACTA
TCGATGGGCAACAGACTATTATTGCATGTATTGAAAGCCACCAGTTTCAGCCTAAAAACTTCTGGAATGGTCGTTGGAGATCAGAGTGGA
AGTTCACCATCACACCACCTACAGCCCAGGTGGTTGGCGTGCTTAAGATTCAGGTTCACTATTATGAAGATGGCAATGTTCAGTTGGTTA
GTCATAAAGATGTACAGGATTCACTAACTGTTTCGAATGAAGCCCAAACTGCCAAGGAGTTTATTAAAATCATAGAGAATGCAGAAAATG
AGTATCAGACAGCAATTAGTGAAAACTATCAAACAATGTCAGATACCACATTCAAGGCCTTGCGCCGGCAGCTTCCAGTTACCCGCACCA
AAATCGACTGGAACAAGATACTCAGCTACAAGATTGGCAAAGAAATGCAGAATGCTTAAAGGCTGAATGTAGGATTCTTCAGTATGTGGA
AAGACAAGGATTCAACGTGTGGTCATATGATAAATAAGTGATTTATAAACAAGAGTGATATTTTGCTAGGGCTTTCAAAGTTAACCGGTT
TTCTAGCCTCATGGAATACTGTTGAACCTATAGCGTTGTCTTGATTCTTTTGTGTTCTCTGCCTTGTAATTTTCTGTTACTGCTATATCT
ACGTGTAAATCTTTTTTTCTTTTTTTTTTTTTTTTTTTGGTTAATTCTGCCACATTTAATGTTGGTGAGAGAGTGATCTATCCTAATGAC
ATTTTACTGTTTAAAAAAGTTTCCTAGCCATGAAGCCCTGCTACTGATTTAGACAAGGTATTATGGTCATTACTTTGTACCCCTATCCTT
CCAAGCACTTCTGGTACTTCAGTCGTTTTTACTGATCCACCAACACCTAAAGAGGCTATGCTACAGTCTCTAGCTAAATGGAAGACACAT
TCATCCTTCTCCCTCTGACTGCTTTGATCATCATTTATTGCATCTCATAACTAATTTTCTAAAGTTTGGATTGGGACTTTTCAGGTCCTT
TTTGGAGGGCAAAGGAAGTGCCAGCTTCTCTGGGGAACTTGTTTTTAAATCCAAAGACTTGAACCACATTCCCTGCACATGAACATGTTT
GCTTTTATCCCTTCTCTCATTGTCTCCTTCCCATCTTAGTACCATTGTAGTTATAAACATCTGCATTTTTTAGAAGCATTTTACCCATTT
ATTTTTTTAAACATTCAAGAACTGCTGACGTACTGTGGATGTAGAGTATAAAACTTGAAAAATGCAGATGTTGAAGGAATAATAGGTATC
TTGTGCTTTAATACTTTATGGCAGGATTGTACTATAAGCAAATGAATTAAACAGCTATGTAAATCATAAAGAAAAACTAAAAATGAACCA
AAGTGAAAGGATAACTTCCAGGCAGTATCTTTCTATTGTAACCTGTTATTTAAGGAAATACTAGTGATTTCTTCTAAATAGGATGTAAAA
CTTCTTTCAAATTACTCTTCCTCAGTCCTGCCTGCCAAGAACTCAAGTGTAACTGTGATAAAATAACCTTTCCCAGGTATATTGGCAGGT
ATGTGTGTAATCTCAGAATACACAGGTGACATAGATATGATATGACAACTGGTAATGGTGGATTCATTTACATTGTTTACACTTCTATGA
CCAGGCCTTAAGGGAAGGTCAGTTTTTTAAAAAACCAAGTAGTGTCTTCCTACCTATCTCCAGATACATGTCAAAAAAAGAAAGGTGTTT
GTGCTTCCGTTTTGTTTCTGCTCAGTAATATAGTCAAGCAAGTTTGTTCCAGGTGACCCATTGAGCTGTGTATGCATTTTTGTTTATTTC
AATAAAATATATTTGTATTATTTGTCCTTCATACTATCCATCCATACCACACTATCTTCTGTATCAGGTAGTCTAATAGAAATATACCTG

>14559_14559_1_CD58-CAPZA1_CD58_chr1_117113524_ENST00000369487_CAPZA1_chr1_113189831_ENST00000263168_length(amino acids)=315AA_BP=42
MNLGLLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVRIAAKFITHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNMDQ
FTPVKIEGYEDQVLITEHGDLGNSRFLDPRNKISFKFDHLRKEASDPQPEEADGGLKSWRESCDSALRAYVKDHYSNGFCTVYAKTIDGQ
QTIIACIESHQFQPKNFWNGRWRSEWKFTITPPTAQVVGVLKIQVHYYEDGNVQLVSHKDVQDSLTVSNEAQTAKEFIKIIENAENEYQT

--------------------------------------------------------------
>14559_14559_2_CD58-CAPZA1_CD58_chr1_117113524_ENST00000369489_CAPZA1_chr1_113189831_ENST00000263168_length(transcript)=2446nt_BP=137nt
GTAGGCGGTGCTTGAACTTAGGGCTGCTTGTGGCTGGGCACTCGCGCAGAGGCCGGCCCGACGAGCCATGGTTGCTGGGAGCGACGCGGG
GCGGGCCCTGGGGGTCCTCAGCGTGGTCTGCCTGCTGCACTGCTTTGGTACGCATAGCTGCTAAATTCATCACTCATGCACCCCCAGGGG
AATTTAATGAAGTATTCAATGACGTTCGGCTACTACTTAATAATGACAATCTCCTCAGGGAAGGGGCAGCACATGCATTTGCCCAGTATA
ACATGGATCAGTTCACGCCTGTGAAGATAGAAGGATATGAAGATCAGGTCTTAATTACAGAGCACGGTGACCTGGGTAATAGCAGATTTT
TAGATCCAAGAAACAAAATTTCCTTTAAATTTGACCACTTACGGAAAGAAGCAAGTGACCCCCAGCCAGAAGAAGCAGATGGAGGTCTGA
AGTCTTGGAGAGAATCCTGTGACAGTGCTTTAAGAGCCTATGTGAAAGACCATTATTCCAACGGCTTCTGTACTGTTTATGCTAAAACTA
TCGATGGGCAACAGACTATTATTGCATGTATTGAAAGCCACCAGTTTCAGCCTAAAAACTTCTGGAATGGTCGTTGGAGATCAGAGTGGA
AGTTCACCATCACACCACCTACAGCCCAGGTGGTTGGCGTGCTTAAGATTCAGGTTCACTATTATGAAGATGGCAATGTTCAGTTGGTTA
GTCATAAAGATGTACAGGATTCACTAACTGTTTCGAATGAAGCCCAAACTGCCAAGGAGTTTATTAAAATCATAGAGAATGCAGAAAATG
AGTATCAGACAGCAATTAGTGAAAACTATCAAACAATGTCAGATACCACATTCAAGGCCTTGCGCCGGCAGCTTCCAGTTACCCGCACCA
AAATCGACTGGAACAAGATACTCAGCTACAAGATTGGCAAAGAAATGCAGAATGCTTAAAGGCTGAATGTAGGATTCTTCAGTATGTGGA
AAGACAAGGATTCAACGTGTGGTCATATGATAAATAAGTGATTTATAAACAAGAGTGATATTTTGCTAGGGCTTTCAAAGTTAACCGGTT
TTCTAGCCTCATGGAATACTGTTGAACCTATAGCGTTGTCTTGATTCTTTTGTGTTCTCTGCCTTGTAATTTTCTGTTACTGCTATATCT
ACGTGTAAATCTTTTTTTCTTTTTTTTTTTTTTTTTTTGGTTAATTCTGCCACATTTAATGTTGGTGAGAGAGTGATCTATCCTAATGAC
ATTTTACTGTTTAAAAAAGTTTCCTAGCCATGAAGCCCTGCTACTGATTTAGACAAGGTATTATGGTCATTACTTTGTACCCCTATCCTT
CCAAGCACTTCTGGTACTTCAGTCGTTTTTACTGATCCACCAACACCTAAAGAGGCTATGCTACAGTCTCTAGCTAAATGGAAGACACAT
TCATCCTTCTCCCTCTGACTGCTTTGATCATCATTTATTGCATCTCATAACTAATTTTCTAAAGTTTGGATTGGGACTTTTCAGGTCCTT
TTTGGAGGGCAAAGGAAGTGCCAGCTTCTCTGGGGAACTTGTTTTTAAATCCAAAGACTTGAACCACATTCCCTGCACATGAACATGTTT
GCTTTTATCCCTTCTCTCATTGTCTCCTTCCCATCTTAGTACCATTGTAGTTATAAACATCTGCATTTTTTAGAAGCATTTTACCCATTT
ATTTTTTTAAACATTCAAGAACTGCTGACGTACTGTGGATGTAGAGTATAAAACTTGAAAAATGCAGATGTTGAAGGAATAATAGGTATC
TTGTGCTTTAATACTTTATGGCAGGATTGTACTATAAGCAAATGAATTAAACAGCTATGTAAATCATAAAGAAAAACTAAAAATGAACCA
AAGTGAAAGGATAACTTCCAGGCAGTATCTTTCTATTGTAACCTGTTATTTAAGGAAATACTAGTGATTTCTTCTAAATAGGATGTAAAA
CTTCTTTCAAATTACTCTTCCTCAGTCCTGCCTGCCAAGAACTCAAGTGTAACTGTGATAAAATAACCTTTCCCAGGTATATTGGCAGGT
ATGTGTGTAATCTCAGAATACACAGGTGACATAGATATGATATGACAACTGGTAATGGTGGATTCATTTACATTGTTTACACTTCTATGA
CCAGGCCTTAAGGGAAGGTCAGTTTTTTAAAAAACCAAGTAGTGTCTTCCTACCTATCTCCAGATACATGTCAAAAAAAGAAAGGTGTTT
GTGCTTCCGTTTTGTTTCTGCTCAGTAATATAGTCAAGCAAGTTTGTTCCAGGTGACCCATTGAGCTGTGTATGCATTTTTGTTTATTTC
AATAAAATATATTTGTATTATTTGTCCTTCATACTATCCATCCATACCACACTATCTTCTGTATCAGGTAGTCTAATAGAAATATACCTG

>14559_14559_2_CD58-CAPZA1_CD58_chr1_117113524_ENST00000369489_CAPZA1_chr1_113189831_ENST00000263168_length(amino acids)=315AA_BP=42
MNLGLLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVRIAAKFITHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNMDQ
FTPVKIEGYEDQVLITEHGDLGNSRFLDPRNKISFKFDHLRKEASDPQPEEADGGLKSWRESCDSALRAYVKDHYSNGFCTVYAKTIDGQ
QTIIACIESHQFQPKNFWNGRWRSEWKFTITPPTAQVVGVLKIQVHYYEDGNVQLVSHKDVQDSLTVSNEAQTAKEFIKIIENAENEYQT

--------------------------------------------------------------
>14559_14559_3_CD58-CAPZA1_CD58_chr1_117113524_ENST00000457047_CAPZA1_chr1_113189831_ENST00000263168_length(transcript)=2433nt_BP=124nt
GAACTTAGGGCTGCTTGTGGCTGGGCACTCGCGCAGAGGCCGGCCCGACGAGCCATGGTTGCTGGGAGCGACGCGGGGCGGGCCCTGGGG
GTCCTCAGCGTGGTCTGCCTGCTGCACTGCTTTGGTACGCATAGCTGCTAAATTCATCACTCATGCACCCCCAGGGGAATTTAATGAAGT
ATTCAATGACGTTCGGCTACTACTTAATAATGACAATCTCCTCAGGGAAGGGGCAGCACATGCATTTGCCCAGTATAACATGGATCAGTT
CACGCCTGTGAAGATAGAAGGATATGAAGATCAGGTCTTAATTACAGAGCACGGTGACCTGGGTAATAGCAGATTTTTAGATCCAAGAAA
CAAAATTTCCTTTAAATTTGACCACTTACGGAAAGAAGCAAGTGACCCCCAGCCAGAAGAAGCAGATGGAGGTCTGAAGTCTTGGAGAGA
ATCCTGTGACAGTGCTTTAAGAGCCTATGTGAAAGACCATTATTCCAACGGCTTCTGTACTGTTTATGCTAAAACTATCGATGGGCAACA
GACTATTATTGCATGTATTGAAAGCCACCAGTTTCAGCCTAAAAACTTCTGGAATGGTCGTTGGAGATCAGAGTGGAAGTTCACCATCAC
ACCACCTACAGCCCAGGTGGTTGGCGTGCTTAAGATTCAGGTTCACTATTATGAAGATGGCAATGTTCAGTTGGTTAGTCATAAAGATGT
ACAGGATTCACTAACTGTTTCGAATGAAGCCCAAACTGCCAAGGAGTTTATTAAAATCATAGAGAATGCAGAAAATGAGTATCAGACAGC
AATTAGTGAAAACTATCAAACAATGTCAGATACCACATTCAAGGCCTTGCGCCGGCAGCTTCCAGTTACCCGCACCAAAATCGACTGGAA
CAAGATACTCAGCTACAAGATTGGCAAAGAAATGCAGAATGCTTAAAGGCTGAATGTAGGATTCTTCAGTATGTGGAAAGACAAGGATTC
AACGTGTGGTCATATGATAAATAAGTGATTTATAAACAAGAGTGATATTTTGCTAGGGCTTTCAAAGTTAACCGGTTTTCTAGCCTCATG
GAATACTGTTGAACCTATAGCGTTGTCTTGATTCTTTTGTGTTCTCTGCCTTGTAATTTTCTGTTACTGCTATATCTACGTGTAAATCTT
TTTTTCTTTTTTTTTTTTTTTTTTTGGTTAATTCTGCCACATTTAATGTTGGTGAGAGAGTGATCTATCCTAATGACATTTTACTGTTTA
AAAAAGTTTCCTAGCCATGAAGCCCTGCTACTGATTTAGACAAGGTATTATGGTCATTACTTTGTACCCCTATCCTTCCAAGCACTTCTG
GTACTTCAGTCGTTTTTACTGATCCACCAACACCTAAAGAGGCTATGCTACAGTCTCTAGCTAAATGGAAGACACATTCATCCTTCTCCC
TCTGACTGCTTTGATCATCATTTATTGCATCTCATAACTAATTTTCTAAAGTTTGGATTGGGACTTTTCAGGTCCTTTTTGGAGGGCAAA
GGAAGTGCCAGCTTCTCTGGGGAACTTGTTTTTAAATCCAAAGACTTGAACCACATTCCCTGCACATGAACATGTTTGCTTTTATCCCTT
CTCTCATTGTCTCCTTCCCATCTTAGTACCATTGTAGTTATAAACATCTGCATTTTTTAGAAGCATTTTACCCATTTATTTTTTTAAACA
TTCAAGAACTGCTGACGTACTGTGGATGTAGAGTATAAAACTTGAAAAATGCAGATGTTGAAGGAATAATAGGTATCTTGTGCTTTAATA
CTTTATGGCAGGATTGTACTATAAGCAAATGAATTAAACAGCTATGTAAATCATAAAGAAAAACTAAAAATGAACCAAAGTGAAAGGATA
ACTTCCAGGCAGTATCTTTCTATTGTAACCTGTTATTTAAGGAAATACTAGTGATTTCTTCTAAATAGGATGTAAAACTTCTTTCAAATT
ACTCTTCCTCAGTCCTGCCTGCCAAGAACTCAAGTGTAACTGTGATAAAATAACCTTTCCCAGGTATATTGGCAGGTATGTGTGTAATCT
CAGAATACACAGGTGACATAGATATGATATGACAACTGGTAATGGTGGATTCATTTACATTGTTTACACTTCTATGACCAGGCCTTAAGG
GAAGGTCAGTTTTTTAAAAAACCAAGTAGTGTCTTCCTACCTATCTCCAGATACATGTCAAAAAAAGAAAGGTGTTTGTGCTTCCGTTTT
GTTTCTGCTCAGTAATATAGTCAAGCAAGTTTGTTCCAGGTGACCCATTGAGCTGTGTATGCATTTTTGTTTATTTCAATAAAATATATT
TGTATTATTTGTCCTTCATACTATCCATCCATACCACACTATCTTCTGTATCAGGTAGTCTAATAGAAATATACCTGTTTTGTTCTAAAA

>14559_14559_3_CD58-CAPZA1_CD58_chr1_117113524_ENST00000457047_CAPZA1_chr1_113189831_ENST00000263168_length(amino acids)=311AA_BP=38
MLVAGHSRRGRPDEPWLLGATRGGPWGSSAWSACCTALVRIAAKFITHAPPGEFNEVFNDVRLLLNNDNLLREGAAHAFAQYNMDQFTPV
KIEGYEDQVLITEHGDLGNSRFLDPRNKISFKFDHLRKEASDPQPEEADGGLKSWRESCDSALRAYVKDHYSNGFCTVYAKTIDGQQTII
ACIESHQFQPKNFWNGRWRSEWKFTITPPTAQVVGVLKIQVHYYEDGNVQLVSHKDVQDSLTVSNEAQTAKEFIKIIENAENEYQTAISE

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Fusion Gene PPI Analysis for CD58-CAPZA1


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CD58-CAPZA1


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CD58-CAPZA1


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCD58C0026769Multiple Sclerosis2CTD_human
HgeneCD58C0751324Multiple Sclerosis, Acute Fulminating2CTD_human
HgeneCD58C0079774Peripheral T-Cell Lymphoma1CTD_human
TgeneC0279626Squamous cell carcinoma of esophagus1CTD_human