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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CD59-CTAGE5 (FusionGDB2 ID:HG966TG4253)

Fusion Gene Summary for CD59-CTAGE5

check button Fusion gene summary
Fusion gene informationFusion gene name: CD59-CTAGE5
Fusion gene ID: hg966tg4253
HgeneTgene
Gene symbol

CD59

CTAGE5

Gene ID

966

4253

Gene nameCD59 molecule (CD59 blood group)MIA SH3 domain ER export factor 2
Synonyms16.3A5|1F5|EJ16|EJ30|EL32|G344|HRF-20|HRF20|MAC-IP|MACIF|MEM43|MIC11|MIN1|MIN2|MIN3|MIRL|MSK21|p18-20CTAGE5|MEA6|MGEA|MGEA11|MGEA6|TALI
Cytomap('CD59')('CTAGE5')

11p13

14q21.1

Type of geneprotein-codingprotein-coding
DescriptionCD59 glycoprotein1F5 antigen20 kDa homologous restriction factorCD59 antigen p18-20 (antigen identified by monoclonal antibodies 16.3A5, EJ16, EJ30, EL32 and G344)CD59 blood group antigenCD59 molecule, complement regulatory proteinLy-6-like proteinmelanoma inhibitory activity protein 2CTAGE family member 5, ER export factorCTAGE family, member 5TANGO1-likecutaneous T-cell lymphoma-associated antigen 5melanoma inhibitory activity 2meningioma expressed antigen 6 (coiled-coil proline-rich)menin
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000351554, ENST00000528700, 
ENST00000395850, ENST00000415002, 
ENST00000426650, ENST00000437761, 
ENST00000445143, ENST00000527577, 
ENST00000533403, ENST00000534312, 
Fusion gene scores* DoF score7 X 11 X 4=3086 X 4 X 5=120
# samples 116
** MAII scorelog2(11/308*10)=-1.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CD59 [Title/Abstract] AND CTAGE5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCD59(33752970)-CTAGE5(39746138), # samples:1
Anticipated loss of major functional domain due to fusion event.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCD59

GO:0030449

regulation of complement activation

25284781

HgeneCD59

GO:1903659

regulation of complement-dependent cytotoxicity

25284781



check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-HU-A4HB-01ACD59chr11

33752970

-CTAGE5chr14

39746138

+


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Fusion Gene ORF analysis for CD59-CTAGE5

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5UTR-3CDSENST00000351554ENST00000341502CD59chr11

33752970

-CTAGE5chr14

39746138

+
5UTR-3CDSENST00000351554ENST00000341749CD59chr11

33752970

-CTAGE5chr14

39746138

+
5UTR-3CDSENST00000528700ENST00000341502CD59chr11

33752970

-CTAGE5chr14

39746138

+
5UTR-3CDSENST00000528700ENST00000341749CD59chr11

33752970

-CTAGE5chr14

39746138

+
5UTR-5UTRENST00000351554ENST00000280083CD59chr11

33752970

-CTAGE5chr14

39746138

+
5UTR-5UTRENST00000351554ENST00000348007CD59chr11

33752970

-CTAGE5chr14

39746138

+
5UTR-5UTRENST00000351554ENST00000396158CD59chr11

33752970

-CTAGE5chr14

39746138

+
5UTR-5UTRENST00000351554ENST00000396165CD59chr11

33752970

-CTAGE5chr14

39746138

+
5UTR-5UTRENST00000351554ENST00000553352CD59chr11

33752970

-CTAGE5chr14

39746138

+
5UTR-5UTRENST00000351554ENST00000556148CD59chr11

33752970

-CTAGE5chr14

39746138

+
5UTR-5UTRENST00000351554ENST00000557038CD59chr11

33752970

-CTAGE5chr14

39746138

+
5UTR-5UTRENST00000528700ENST00000280083CD59chr11

33752970

-CTAGE5chr14

39746138

+
5UTR-5UTRENST00000528700ENST00000348007CD59chr11

33752970

-CTAGE5chr14

39746138

+
5UTR-5UTRENST00000528700ENST00000396158CD59chr11

33752970

-CTAGE5chr14

39746138

+
5UTR-5UTRENST00000528700ENST00000396165CD59chr11

33752970

-CTAGE5chr14

39746138

+
5UTR-5UTRENST00000528700ENST00000553352CD59chr11

33752970

-CTAGE5chr14

39746138

+
5UTR-5UTRENST00000528700ENST00000556148CD59chr11

33752970

-CTAGE5chr14

39746138

+
5UTR-5UTRENST00000528700ENST00000557038CD59chr11

33752970

-CTAGE5chr14

39746138

+
5UTR-intronENST00000351554ENST00000553383CD59chr11

33752970

-CTAGE5chr14

39746138

+
5UTR-intronENST00000528700ENST00000553383CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-3CDSENST00000395850ENST00000341502CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-3CDSENST00000395850ENST00000341749CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-3CDSENST00000415002ENST00000341502CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-3CDSENST00000415002ENST00000341749CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-3CDSENST00000426650ENST00000341502CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-3CDSENST00000426650ENST00000341749CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-3CDSENST00000437761ENST00000341502CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-3CDSENST00000437761ENST00000341749CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-3CDSENST00000445143ENST00000341502CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-3CDSENST00000445143ENST00000341749CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-3CDSENST00000527577ENST00000341502CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-3CDSENST00000527577ENST00000341749CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-3CDSENST00000533403ENST00000341502CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-3CDSENST00000533403ENST00000341749CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-3CDSENST00000534312ENST00000341502CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-3CDSENST00000534312ENST00000341749CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000395850ENST00000280083CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000395850ENST00000348007CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000395850ENST00000396158CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000395850ENST00000396165CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000395850ENST00000553352CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000395850ENST00000556148CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000395850ENST00000557038CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000415002ENST00000280083CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000415002ENST00000348007CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000415002ENST00000396158CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000415002ENST00000396165CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000415002ENST00000553352CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000415002ENST00000556148CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000415002ENST00000557038CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000426650ENST00000280083CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000426650ENST00000348007CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000426650ENST00000396158CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000426650ENST00000396165CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000426650ENST00000553352CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000426650ENST00000556148CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000426650ENST00000557038CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000437761ENST00000280083CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000437761ENST00000348007CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000437761ENST00000396158CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000437761ENST00000396165CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000437761ENST00000553352CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000437761ENST00000556148CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000437761ENST00000557038CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000445143ENST00000280083CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000445143ENST00000348007CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000445143ENST00000396158CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000445143ENST00000396165CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000445143ENST00000553352CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000445143ENST00000556148CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000445143ENST00000557038CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000527577ENST00000280083CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000527577ENST00000348007CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000527577ENST00000396158CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000527577ENST00000396165CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000527577ENST00000553352CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000527577ENST00000556148CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000527577ENST00000557038CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000533403ENST00000280083CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000533403ENST00000348007CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000533403ENST00000396158CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000533403ENST00000396165CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000533403ENST00000553352CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000533403ENST00000556148CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000533403ENST00000557038CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000534312ENST00000280083CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000534312ENST00000348007CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000534312ENST00000396158CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000534312ENST00000396165CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000534312ENST00000553352CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000534312ENST00000556148CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-5UTRENST00000534312ENST00000557038CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-intronENST00000395850ENST00000553383CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-intronENST00000415002ENST00000553383CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-intronENST00000426650ENST00000553383CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-intronENST00000437761ENST00000553383CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-intronENST00000445143ENST00000553383CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-intronENST00000527577ENST00000553383CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-intronENST00000533403ENST00000553383CD59chr11

33752970

-CTAGE5chr14

39746138

+
intron-intronENST00000534312ENST00000553383CD59chr11

33752970

-CTAGE5chr14

39746138

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score

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Fusion Genomic Features for CD59-CTAGE5


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CD59chr1133752969-CTAGE5chr1439746137+0.0001977690.9998023
CD59chr1133752969-CTAGE5chr1439746137+0.0001977690.9998023


check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CD59-CTAGE5


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/:33752970/:39746138)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note


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Fusion Gene Sequence for CD59-CTAGE5


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

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Fusion Gene PPI Analysis for CD59-CTAGE5


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CD59-CTAGE5


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CD59-CTAGE5


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCD59C2676767CD59 Deficiency4CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneCD59C0024790Paroxysmal nocturnal hemoglobinuria1GENOMICS_ENGLAND
HgeneCD59C0272242Complement deficiency disease1GENOMICS_ENGLAND
HgeneCD59C1148551X-Linked Dyskeratosis Congenita1GENOMICS_ENGLAND
HgeneCD59C4727002Chronic Hemolysis1GENOMICS_ENGLAND
HgeneCD59C4755276Primary CD59 deficiency1GENOMICS_ENGLAND