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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP32-PRDM10 (FusionGDB2 ID:HG9743TG56980)

Fusion Gene Summary for ARHGAP32-PRDM10

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP32-PRDM10
Fusion gene ID: hg9743tg56980
HgeneTgene
Gene symbol

ARHGAP32

PRDM10

Gene ID

9743

56980

Gene nameRho GTPase activating protein 32PR/SET domain 10
SynonymsGC-GAP|GRIT|PX-RICS|RICS|p200RhoGAP|p250GAPPFM7|TRIS
Cytomap('ARHGAP32')('PRDM10')

11q24.3

11q24.3

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 32GAB-associated CDC42GAB-associated Cdc42/Rac GTPase-activating proteinGTPase regulator interacting with TrkAGTPase-activating protein for Cdc42 and Rac1RhoGAP involved in the -catenin-N-cadherin and NMDA receptor signaPR domain zinc finger protein 10PR domain 10PR domain containing 10PR domain-containing protein 10PR-domain family member 7PRDM zinc finger transcription factortristanin
Modification date2020032720200328
UniProtAcc

A7KAX9

.
Ensembl transtripts involved in fusion geneENST00000310343, ENST00000524655, 
ENST00000392657, ENST00000527272, 
Fusion gene scores* DoF score10 X 9 X 5=4504 X 4 X 3=48
# samples 114
** MAII scorelog2(11/450*10)=-2.03242147769238
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP32 [Title/Abstract] AND PRDM10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP32(128963516)-PRDM10(129782120), # samples:3
Anticipated loss of major functional domain due to fusion event.ARHGAP32-PRDM10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP32-PRDM10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP32-PRDM10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP32-PRDM10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARHGAP32 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across PRDM10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-YL-A8SK-01BARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
ChimerDB4PRADTCGA-YL-A8SKARHGAP32chr11

128963516

-PRDM10chr11

129782120

-


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Fusion Gene ORF analysis for ARHGAP32-PRDM10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-intronENST00000310343ENST00000304538ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
5CDS-intronENST00000310343ENST00000360871ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
5CDS-intronENST00000310343ENST00000423662ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
5CDS-intronENST00000310343ENST00000526082ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
5CDS-intronENST00000310343ENST00000528746ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
5CDS-intronENST00000524655ENST00000304538ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
5CDS-intronENST00000524655ENST00000360871ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
5CDS-intronENST00000524655ENST00000423662ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
5CDS-intronENST00000524655ENST00000526082ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
5CDS-intronENST00000524655ENST00000528746ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
In-frameENST00000310343ENST00000358825ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
In-frameENST00000524655ENST00000358825ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-3CDSENST00000392657ENST00000358825ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-3CDSENST00000527272ENST00000358825ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-intronENST00000392657ENST00000304538ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-intronENST00000392657ENST00000360871ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-intronENST00000392657ENST00000423662ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-intronENST00000392657ENST00000526082ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-intronENST00000392657ENST00000528746ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-intronENST00000527272ENST00000304538ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-intronENST00000527272ENST00000360871ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-intronENST00000527272ENST00000423662ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-intronENST00000527272ENST00000526082ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-
intron-intronENST00000527272ENST00000528746ARHGAP32chr11

128963516

-PRDM10chr11

129782120

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000310343ARHGAP32chr11128963516-ENST00000358825PRDM10chr11129782120-372648901118372
ENST00000524655ARHGAP32chr11128963516-ENST00000358825PRDM10chr11129782120-352829124920298

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000310343ENST00000358825ARHGAP32chr11128963516-PRDM10chr11129782120-0.0001515190.9998485
ENST00000524655ENST00000358825ARHGAP32chr11128963516-PRDM10chr11129782120-0.0002392170.9997608

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Fusion Genomic Features for ARHGAP32-PRDM10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ARHGAP32-PRDM10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:128963516/chr11:129782120)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ARHGAP32

A7KAX9

.
FUNCTION: GTPase-activating protein (GAP) promoting GTP hydrolysis on RHOA, CDC42 and RAC1 small GTPases. May be involved in the differentiation of neuronal cells during the formation of neurite extensions. Involved in NMDA receptor activity-dependent actin reorganization in dendritic spines. May mediate cross-talks between Ras- and Rho-regulated signaling pathways in cell growth regulation. Isoform 2 has higher GAP activity (By similarity). {ECO:0000250, ECO:0000269|PubMed:12446789, ECO:0000269|PubMed:12454018, ECO:0000269|PubMed:12531901, ECO:0000269|PubMed:12788081, ECO:0000269|PubMed:12819203, ECO:0000269|PubMed:12857875, ECO:0000269|PubMed:17663722}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgenePRDM10chr11:128963516chr11:129782120ENST000003045380161131_113401024.0Compositional biasNote=Poly-Thr
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016866_91601024.0Compositional biasNote=Thr-rich
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016918_103101024.0Compositional biasNote=Gln-rich
TgenePRDM10chr11:128963516chr11:129782120ENST0000035882517221131_11349511161.0Compositional biasNote=Poly-Thr
TgenePRDM10chr11:128963516chr11:129782120ENST0000036087116211131_11349471157.0Compositional biasNote=Poly-Thr
TgenePRDM10chr11:128963516chr11:129782120ENST0000042366213181131_11348651062.0Compositional biasNote=Poly-Thr
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318866_9168651062.0Compositional biasNote=Thr-rich
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318918_10318651062.0Compositional biasNote=Gln-rich
TgenePRDM10chr11:128963516chr11:129782120ENST0000052608213181131_11348651075.0Compositional biasNote=Poly-Thr
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318866_9168651075.0Compositional biasNote=Thr-rich
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318918_10318651075.0Compositional biasNote=Gln-rich
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016208_32601024.0DomainSET
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016355_37701024.0Zinc fingerC2H2-type 1
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016530_55201024.0Zinc fingerC2H2-type 2
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016560_58201024.0Zinc fingerC2H2-type 3
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016588_61001024.0Zinc fingerC2H2-type 4
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016616_63901024.0Zinc fingerC2H2-type 5
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016644_66601024.0Zinc fingerC2H2-type 6
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016672_69501024.0Zinc fingerC2H2-type 7
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016727_75001024.0Zinc fingerC2H2-type 8
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016772_79501024.0Zinc fingerC2H2-type 9
TgenePRDM10chr11:128963516chr11:129782120ENST00000304538016834_85701024.0Zinc fingerC2H2-type 10

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000310343-5221031_10361632088.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000310343-5221305_13101632088.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000392657-1131031_103601739.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000392657-1131305_131001739.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000527272-1121031_103601739.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000527272-1121305_131001739.0Compositional biasNote=Poly-Pro
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000310343-522131_2451632088.0DomainNote=PX%3B atypical
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000310343-522259_3211632088.0DomainSH3
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000310343-522372_5671632088.0DomainRho-GAP
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000392657-113131_24501739.0DomainNote=PX%3B atypical
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000392657-113259_32101739.0DomainSH3
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000392657-113372_56701739.0DomainRho-GAP
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000527272-112131_24501739.0DomainNote=PX%3B atypical
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000527272-112259_32101739.0DomainSH3
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000527272-112372_56701739.0DomainRho-GAP
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722866_9169511161.0Compositional biasNote=Thr-rich
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722918_10319511161.0Compositional biasNote=Gln-rich
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621866_9169471157.0Compositional biasNote=Thr-rich
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621918_10319471157.0Compositional biasNote=Gln-rich
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722208_3269511161.0DomainSET
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621208_3269471157.0DomainSET
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318208_3268651062.0DomainSET
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318208_3268651075.0DomainSET
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722355_3779511161.0Zinc fingerC2H2-type 1
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722530_5529511161.0Zinc fingerC2H2-type 2
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722560_5829511161.0Zinc fingerC2H2-type 3
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722588_6109511161.0Zinc fingerC2H2-type 4
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722616_6399511161.0Zinc fingerC2H2-type 5
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722644_6669511161.0Zinc fingerC2H2-type 6
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722672_6959511161.0Zinc fingerC2H2-type 7
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722727_7509511161.0Zinc fingerC2H2-type 8
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722772_7959511161.0Zinc fingerC2H2-type 9
TgenePRDM10chr11:128963516chr11:129782120ENST000003588251722834_8579511161.0Zinc fingerC2H2-type 10
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621355_3779471157.0Zinc fingerC2H2-type 1
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621530_5529471157.0Zinc fingerC2H2-type 2
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621560_5829471157.0Zinc fingerC2H2-type 3
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621588_6109471157.0Zinc fingerC2H2-type 4
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621616_6399471157.0Zinc fingerC2H2-type 5
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621644_6669471157.0Zinc fingerC2H2-type 6
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621672_6959471157.0Zinc fingerC2H2-type 7
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621727_7509471157.0Zinc fingerC2H2-type 8
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621772_7959471157.0Zinc fingerC2H2-type 9
TgenePRDM10chr11:128963516chr11:129782120ENST000003608711621834_8579471157.0Zinc fingerC2H2-type 10
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318355_3778651062.0Zinc fingerC2H2-type 1
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318530_5528651062.0Zinc fingerC2H2-type 2
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318560_5828651062.0Zinc fingerC2H2-type 3
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318588_6108651062.0Zinc fingerC2H2-type 4
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318616_6398651062.0Zinc fingerC2H2-type 5
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318644_6668651062.0Zinc fingerC2H2-type 6
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318672_6958651062.0Zinc fingerC2H2-type 7
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318727_7508651062.0Zinc fingerC2H2-type 8
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318772_7958651062.0Zinc fingerC2H2-type 9
TgenePRDM10chr11:128963516chr11:129782120ENST000004236621318834_8578651062.0Zinc fingerC2H2-type 10
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318355_3778651075.0Zinc fingerC2H2-type 1
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318530_5528651075.0Zinc fingerC2H2-type 2
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318560_5828651075.0Zinc fingerC2H2-type 3
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318588_6108651075.0Zinc fingerC2H2-type 4
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318616_6398651075.0Zinc fingerC2H2-type 5
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318644_6668651075.0Zinc fingerC2H2-type 6
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318672_6958651075.0Zinc fingerC2H2-type 7
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318727_7508651075.0Zinc fingerC2H2-type 8
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318772_7958651075.0Zinc fingerC2H2-type 9
TgenePRDM10chr11:128963516chr11:129782120ENST000005260821318834_8578651075.0Zinc fingerC2H2-type 10


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Fusion Gene Sequence for ARHGAP32-PRDM10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6077_6077_1_ARHGAP32-PRDM10_ARHGAP32_chr11_128963516_ENST00000310343_PRDM10_chr11_129782120_ENST00000358825_length(transcript)=3726nt_BP=489nt
ATGGAGACTGAAAGTGAGAGTAGCACTTTAGGGGATGACAGTGTCTTCTGGTTGGAGTCTGAAGTTATAATCCAGGTGACTGACTGTGAA
GAGGAAGAAAGGGAAGAGAAGTTCAGGAAGATGAAGTCCTCAGTACATTCTGAAGAAGATGATTTTGTTCCAGAGCTACATAGAAATGTA
CACCCTCGAGAGCGGCCTGATTGGGAAGAAACTCTTAGCGCAATGGCAAGAGGCGCAGATGTTCCAGAGATTCCTGGAGATCTTACTCTT
AAGACGTGTGGCAGTACAGCCAGTATGAAGGTTAAGCATGTGAAAAAGTTACCCTTCACTAAAGGTCACTTTCCGAAGATGGCTGAATGT
GCGCATTTCCATTATGAGAATGTTGAGTTCGGCAGCATACAGCTTTCACTTTCAGAAGAACAGAATGAAGTAATGAAAAATGGCTGTGAA
TCTAAAGAGCTGGTCTACCTCGTGCAGATTGCTTGTCAGGCCACTTCCCCTCACCAGTCACAGCAGTCCACTGTGGATGTTGGCCAGCTC
CATGATCCTCAGCCCTACCCCCAGCACGCCATCCAGGTGCAGCACATCCAGGTCAGCGAGCCTACCGCCTCGGCCCCGTCCTCCGCCCAG
GTATCTGGGCAGCCGTTGAGTCCCTCAGCCCAGCAGGCTCAGCAGGGGCTCAGCCCCTCCCACATCCAGGGCAGTTCTTCCACACAGGGG
CAGGCTCTGCAGCAGCAGCAGCAGCAGCAGCAGAATTCCTCTGTGCAGCACACGTACCTGCCCAGTGCTTGGAATTCCTTCCGTGGCTAT
TCATCTGAGATTCAAATGATGACGCTTCCTCCGGGTCAGTTTGTGATTACAGACAGTGGTGTGGCAACTCCAGTTACTACTGGCCAGGTG
AAGGCGGTTACTTCGGGTCATTATGTGTTATCAGAAAGTCAATCAGAATTGGAAGAAAAGCAAACTTCTGCCCTCTCTGGTGGAGTCCAG
GTCGAGCCACCTGCACACAGTGACTCCCTGGACCCCCAGACCAACAGCCAACAGCAGACCACACAGTACATCATCACCACCACCACCAAC
GGGAACGGAAGCAGCGAAGTGCATATCACCAAACCATGACTTCCACCCTGGAGCTTGAATCCAGCACCCACCTCATGTCTGTTCTCATAA
GTCTGAAAGCTCTGACACGTAGAGCTCTTTTGTAAGATTTATTATTCACTCAAGAGTTCGGAAACCACAGTTTTGTCTCTCATCCATACA
CTGGGGTTTATTTTGCCAAGGTCATCTTTATCAAATTGACTCTTCAAACCCTCGGTTTTTGCCACAGAACAGAGATCTTTCAGGGGAAAG
TAGATTTCGAGGTGGAGAGAATTTGCCTTGCTCTTGAGCTGGTCTTTTAACATACTGACGAGCCTTACTTTTCCTTTGTGGAAATATTAA
GTGGCATATTGTGTTCATACCAAAGGTGGAGACAGGATGTGCCAAGTTCATGGTTACTGGACTTCTTATTCCAAGCCATGGCACCAAAGG
AGAAGGGGCATTTTGTGGGTGTGCATTAGGTCTGAACTGCTTTATCTTGTTTTAGTTTTCAGTAATTTAACAAAGGGAGCCTGCTGAATA
ACAAAATTAAAATGATGAAACAAAAGTTTGACAGTGATATTCTGAAGCAAAAACTGTCATCTAAATTTTTCTTGCTGATTTTTTTTAACT
TCCCTATTTTAGAAAACTATTGTTGGGCTGTTGGTAGTGCTTTCCACAGATGCTGGTCCTCAGTGGATTAGGTCAGAAGCTCATGTTCTG
ATAGTTCTTCATTATTTCACAAAGGTGGACAACCTGAAAGAGAAAAGGCTGCTTGATGTCAGCAGAATCTAAACCCCTACATTAAAGCTT
TGCCTCCCATTCTGTGGTTGTGGTGGTGGTAAGAAGGAGATATTGGTACCAAGAAAAATTTCCAAAACTATTGAGAGAGAGAGAGAGAAA
GTATTGAAATTTTGTTCTGCCTTGCAGGATCCATTTATCATTCATTGGTAAAGGATATATTCCTTGTTCTTACCAAGTGTACATTTAACT
CTTGCTGACATGTTCAGTGTATTTTATTACTTTTAATGCTGTCTTAAAATGAACATTCTTTAAAGTTGGACAGGAAGGTGGCATTTCTTA
TTTATTAACATTTTTAACTTTAAACATATTGTGACTCATCTAGACCTTTTAATAAGACGGTCAACTTCACACTTAGGGAAAAAATTAAAA
TGTGATGGCCACTTCTAATAATTCAGGTAGTTATAAGGGATCTGGAAGAAATCCAGTCTTTATGAATATACTATTAGTTGGGCATTAAAA
AATCAGTATATATTTTAACTTTTTGTGACATGCTAACACATTTTCAGAATAATTATTGCATAGTAGAATTTATTACTCCAGAACAGAAAG
ACCTTACTTCATTTCAAATGAAGTTAATTAATTTACATTTCTGGGTAAAAACTGGTTCTATAAATTAAGTAGAGTAGCTTCTTTATGATA
AAGACAATTTTCTGAAAAGTGAACAATTCTGTTAAAAGAACTTTATTGATGTGTAGATTTCGCACTTTATTTCTGAGACTGCGTTCATGT
AGTTGTTCCCCAATGTTTGAGTACTAAGAGAACTTGAGAAAATTACTTCATAAACATATGGAAACTGAAAATGGACTCTCTTTGTGACAA
AGATATTCAACAGAAAATATTGACCCTGCATTGCAAAACACAGGTTCGGGTTCCCTAAGTCCCACAGTGTAATGATTACAAATATCCTAG
TGTCCGGTCTAGAAAGACTTTCTAGGAGAAGACTAGTGGAATTTTCTAAAGGTTCAGTTTTAGCTTTTATAACTTAAATTTGGCCCTGTT
ACGTTCTTTTTAATTTGAACCATAAGGTATCTCCCCTCCCTTCAGGAATAACTTATTGGAAAACTGAAAAGAATCACTGAATGGAATGTT
CATTTTATGGCAGTTGTTTTAAGTTTTAAAATACACAGAGGAAAATATTGTGGAAGGACCTCTTTGTTGCTTTCCCTTCTAAGTTGTCTT
CTTCTTCTTCTTCTTCTTCTTCTTCTTTGGTCCTTAAGTGAAATAAAGACTCTAAAACTAATTTGTATATTATCAGCCAGAGATGCGGAT
GGCAGTCGAGCCAAATCGCATGGCTTTCAGATCAGGTATTCTGCACATTCATTCCAAGGTCATAGATTTTTAAAAGGACCTGGATTTGAA
GAGATGGCAAATGATGAGCCATCAGAAAACTTAATTTGGAAAACATGTATGTAGCCAGTGTGGATATTGTGGCCTCTCTCAAGACACATT
GACACTGTAGACTTCATTCAGTCCAGTGTGAGTATTTTGGAGTAGGTTGGATGTAGATTTTGTTTTTATCATTGATTTGTACCGACAGAA
ATAGACATTTCATCATGTAAAATTCCTGTTATTCTGGAAAAACCTATTGTTTTGATCTTCTTGTTTTCTGACTTGGAAGTATCCTTTCAA
AAAAACTCTTAAGATATCTAGGTCTAAAAAGCACTTCATGAGATGCTAAAGCTGACCCACTGGTTGAAAATGTTGACCCTATCCTGTTAT
TTAAATGTGAACATTTATTGTACATTCAGTGAGTTATAGTGTTAATAGTCTTGTGCTATGCAGCAGGTGTAAAAATTAATAAATATATTT
TTTAATAAACATGTTTGTATGTGTGAAGCTACAAGA

>6077_6077_1_ARHGAP32-PRDM10_ARHGAP32_chr11_128963516_ENST00000310343_PRDM10_chr11_129782120_ENST00000358825_length(amino acids)=372AA_BP=162
METESESSTLGDDSVFWLESEVIIQVTDCEEEEREEKFRKMKSSVHSEEDDFVPELHRNVHPRERPDWEETLSAMARGADVPEIPGDLTL
KTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQATSPHQSQQSTVDVGQL
HDPQPYPQHAIQVQHIQVSEPTASAPSSAQVSGQPLSPSAQQAQQGLSPSHIQGSSSTQGQALQQQQQQQQNSSVQHTYLPSAWNSFRGY
SSEIQMMTLPPGQFVITDSGVATPVTTGQVKAVTSGHYVLSESQSELEEKQTSALSGGVQVEPPAHSDSLDPQTNSQQQTTQYIITTTTN
GNGSSEVHITKP

--------------------------------------------------------------
>6077_6077_2_ARHGAP32-PRDM10_ARHGAP32_chr11_128963516_ENST00000524655_PRDM10_chr11_129782120_ENST00000358825_length(transcript)=3528nt_BP=291nt
GATTGGGAAGAAACTCTTAGCGCAATGGCAAGAGGCGCAGATGTTCCAGAGATTCCTGGAGATCTTACTCTTAAGACGTGTGGCAGTACA
GCCAGTATGAAGGTTAAGCATGTGAAAAAGTTACCCTTCACTAAAGGTCACTTTCCGAAGATGGCTGAATGTGCGCATTTCCATTATGAG
AATGTTGAGTTCGGCAGCATACAGCTTTCACTTTCAGAAGAACAGAATGAAGTAATGAAAAATGGCTGTGAATCTAAAGAGCTGGTCTAC
CTCGTGCAGATTGCTTGTCAGGCCACTTCCCCTCACCAGTCACAGCAGTCCACTGTGGATGTTGGCCAGCTCCATGATCCTCAGCCCTAC
CCCCAGCACGCCATCCAGGTGCAGCACATCCAGGTCAGCGAGCCTACCGCCTCGGCCCCGTCCTCCGCCCAGGTATCTGGGCAGCCGTTG
AGTCCCTCAGCCCAGCAGGCTCAGCAGGGGCTCAGCCCCTCCCACATCCAGGGCAGTTCTTCCACACAGGGGCAGGCTCTGCAGCAGCAG
CAGCAGCAGCAGCAGAATTCCTCTGTGCAGCACACGTACCTGCCCAGTGCTTGGAATTCCTTCCGTGGCTATTCATCTGAGATTCAAATG
ATGACGCTTCCTCCGGGTCAGTTTGTGATTACAGACAGTGGTGTGGCAACTCCAGTTACTACTGGCCAGGTGAAGGCGGTTACTTCGGGT
CATTATGTGTTATCAGAAAGTCAATCAGAATTGGAAGAAAAGCAAACTTCTGCCCTCTCTGGTGGAGTCCAGGTCGAGCCACCTGCACAC
AGTGACTCCCTGGACCCCCAGACCAACAGCCAACAGCAGACCACACAGTACATCATCACCACCACCACCAACGGGAACGGAAGCAGCGAA
GTGCATATCACCAAACCATGACTTCCACCCTGGAGCTTGAATCCAGCACCCACCTCATGTCTGTTCTCATAAGTCTGAAAGCTCTGACAC
GTAGAGCTCTTTTGTAAGATTTATTATTCACTCAAGAGTTCGGAAACCACAGTTTTGTCTCTCATCCATACACTGGGGTTTATTTTGCCA
AGGTCATCTTTATCAAATTGACTCTTCAAACCCTCGGTTTTTGCCACAGAACAGAGATCTTTCAGGGGAAAGTAGATTTCGAGGTGGAGA
GAATTTGCCTTGCTCTTGAGCTGGTCTTTTAACATACTGACGAGCCTTACTTTTCCTTTGTGGAAATATTAAGTGGCATATTGTGTTCAT
ACCAAAGGTGGAGACAGGATGTGCCAAGTTCATGGTTACTGGACTTCTTATTCCAAGCCATGGCACCAAAGGAGAAGGGGCATTTTGTGG
GTGTGCATTAGGTCTGAACTGCTTTATCTTGTTTTAGTTTTCAGTAATTTAACAAAGGGAGCCTGCTGAATAACAAAATTAAAATGATGA
AACAAAAGTTTGACAGTGATATTCTGAAGCAAAAACTGTCATCTAAATTTTTCTTGCTGATTTTTTTTAACTTCCCTATTTTAGAAAACT
ATTGTTGGGCTGTTGGTAGTGCTTTCCACAGATGCTGGTCCTCAGTGGATTAGGTCAGAAGCTCATGTTCTGATAGTTCTTCATTATTTC
ACAAAGGTGGACAACCTGAAAGAGAAAAGGCTGCTTGATGTCAGCAGAATCTAAACCCCTACATTAAAGCTTTGCCTCCCATTCTGTGGT
TGTGGTGGTGGTAAGAAGGAGATATTGGTACCAAGAAAAATTTCCAAAACTATTGAGAGAGAGAGAGAGAAAGTATTGAAATTTTGTTCT
GCCTTGCAGGATCCATTTATCATTCATTGGTAAAGGATATATTCCTTGTTCTTACCAAGTGTACATTTAACTCTTGCTGACATGTTCAGT
GTATTTTATTACTTTTAATGCTGTCTTAAAATGAACATTCTTTAAAGTTGGACAGGAAGGTGGCATTTCTTATTTATTAACATTTTTAAC
TTTAAACATATTGTGACTCATCTAGACCTTTTAATAAGACGGTCAACTTCACACTTAGGGAAAAAATTAAAATGTGATGGCCACTTCTAA
TAATTCAGGTAGTTATAAGGGATCTGGAAGAAATCCAGTCTTTATGAATATACTATTAGTTGGGCATTAAAAAATCAGTATATATTTTAA
CTTTTTGTGACATGCTAACACATTTTCAGAATAATTATTGCATAGTAGAATTTATTACTCCAGAACAGAAAGACCTTACTTCATTTCAAA
TGAAGTTAATTAATTTACATTTCTGGGTAAAAACTGGTTCTATAAATTAAGTAGAGTAGCTTCTTTATGATAAAGACAATTTTCTGAAAA
GTGAACAATTCTGTTAAAAGAACTTTATTGATGTGTAGATTTCGCACTTTATTTCTGAGACTGCGTTCATGTAGTTGTTCCCCAATGTTT
GAGTACTAAGAGAACTTGAGAAAATTACTTCATAAACATATGGAAACTGAAAATGGACTCTCTTTGTGACAAAGATATTCAACAGAAAAT
ATTGACCCTGCATTGCAAAACACAGGTTCGGGTTCCCTAAGTCCCACAGTGTAATGATTACAAATATCCTAGTGTCCGGTCTAGAAAGAC
TTTCTAGGAGAAGACTAGTGGAATTTTCTAAAGGTTCAGTTTTAGCTTTTATAACTTAAATTTGGCCCTGTTACGTTCTTTTTAATTTGA
ACCATAAGGTATCTCCCCTCCCTTCAGGAATAACTTATTGGAAAACTGAAAAGAATCACTGAATGGAATGTTCATTTTATGGCAGTTGTT
TTAAGTTTTAAAATACACAGAGGAAAATATTGTGGAAGGACCTCTTTGTTGCTTTCCCTTCTAAGTTGTCTTCTTCTTCTTCTTCTTCTT
CTTCTTCTTTGGTCCTTAAGTGAAATAAAGACTCTAAAACTAATTTGTATATTATCAGCCAGAGATGCGGATGGCAGTCGAGCCAAATCG
CATGGCTTTCAGATCAGGTATTCTGCACATTCATTCCAAGGTCATAGATTTTTAAAAGGACCTGGATTTGAAGAGATGGCAAATGATGAG
CCATCAGAAAACTTAATTTGGAAAACATGTATGTAGCCAGTGTGGATATTGTGGCCTCTCTCAAGACACATTGACACTGTAGACTTCATT
CAGTCCAGTGTGAGTATTTTGGAGTAGGTTGGATGTAGATTTTGTTTTTATCATTGATTTGTACCGACAGAAATAGACATTTCATCATGT
AAAATTCCTGTTATTCTGGAAAAACCTATTGTTTTGATCTTCTTGTTTTCTGACTTGGAAGTATCCTTTCAAAAAAACTCTTAAGATATC
TAGGTCTAAAAAGCACTTCATGAGATGCTAAAGCTGACCCACTGGTTGAAAATGTTGACCCTATCCTGTTATTTAAATGTGAACATTTAT
TGTACATTCAGTGAGTTATAGTGTTAATAGTCTTGTGCTATGCAGCAGGTGTAAAAATTAATAAATATATTTTTTAATAAACATGTTTGT
ATGTGTGAAGCTACAAGA

>6077_6077_2_ARHGAP32-PRDM10_ARHGAP32_chr11_128963516_ENST00000524655_PRDM10_chr11_129782120_ENST00000358825_length(amino acids)=298AA_BP=88
MARGADVPEIPGDLTLKTCGSTASMKVKHVKKLPFTKGHFPKMAECAHFHYENVEFGSIQLSLSEEQNEVMKNGCESKELVYLVQIACQA
TSPHQSQQSTVDVGQLHDPQPYPQHAIQVQHIQVSEPTASAPSSAQVSGQPLSPSAQQAQQGLSPSHIQGSSSTQGQALQQQQQQQQNSS
VQHTYLPSAWNSFRGYSSEIQMMTLPPGQFVITDSGVATPVTTGQVKAVTSGHYVLSESQSELEEKQTSALSGGVQVEPPAHSDSLDPQT
NSQQQTTQYIITTTTNGNGSSEVHITKP

--------------------------------------------------------------

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Fusion Gene PPI Analysis for ARHGAP32-PRDM10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000310343-5221685_2087163.02088.0FYN
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000392657-1131685_208701739.0FYN
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000527272-1121685_208701739.0FYN
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000310343-5221391_1711163.02088.0GAB2
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000392657-1131391_171101739.0GAB2
HgeneARHGAP32chr11:128963516chr11:129782120ENST00000527272-1121391_171101739.0GAB2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP32-PRDM10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGAP32-PRDM10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneARHGAP32C0036341Schizophrenia1PSYGENET