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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:CKAP5-TMEM135 (FusionGDB2 ID:HG9793TG65084)

Fusion Gene Summary for CKAP5-TMEM135

check button Fusion gene summary
Fusion gene informationFusion gene name: CKAP5-TMEM135
Fusion gene ID: hg9793tg65084
HgeneTgene
Gene symbol

CKAP5

TMEM135

Gene ID

9793

65084

Gene namecytoskeleton associated protein 5transmembrane protein 135
SynonymsCHTOG|MSPS|TOG|TOGp|ch-TOGPMP52
Cytomap('CKAP5')('TMEM135')

11p11.2

11q14.2

Type of geneprotein-codingprotein-coding
Descriptioncytoskeleton-associated protein 5colonic and hepatic tumor over-expressed gene proteincolonic and hepatic tumor overexpressed gene proteintransmembrane protein 135peroxisomal membrane protein 52
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000312055, ENST00000354558, 
ENST00000415402, ENST00000529230, 
ENST00000532321, 
Fusion gene scores* DoF score9 X 9 X 5=40511 X 9 X 7=693
# samples 912
** MAII scorelog2(9/405*10)=-2.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/693*10)=-2.5298209465287
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CKAP5 [Title/Abstract] AND TMEM135 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCKAP5(46797805)-TMEM135(86778736), # samples:4
Anticipated loss of major functional domain due to fusion event.CKAP5-TMEM135 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CKAP5-TMEM135 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CKAP5-TMEM135 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CKAP5-TMEM135 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCKAP5

GO:0090063

positive regulation of microtubule nucleation

26414402


check buttonFusion gene breakpoints across CKAP5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across TMEM135 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-FG-5963-01ACKAP5chr11

46797805

-TMEM135chr11

86778736

+
ChimerDB4LGGTCGA-FG-5963-02ACKAP5chr11

46797805

-TMEM135chr11

86778736

+
ChimerDB4LGGTCGA-FG-5963CKAP5chr11

46797805

-TMEM135chr11

86778736

+


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Fusion Gene ORF analysis for CKAP5-TMEM135

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000312055ENST00000355734CKAP5chr11

46797805

-TMEM135chr11

86778736

+
5CDS-5UTRENST00000312055ENST00000535167CKAP5chr11

46797805

-TMEM135chr11

86778736

+
5CDS-5UTRENST00000354558ENST00000355734CKAP5chr11

46797805

-TMEM135chr11

86778736

+
5CDS-5UTRENST00000354558ENST00000535167CKAP5chr11

46797805

-TMEM135chr11

86778736

+
5CDS-5UTRENST00000415402ENST00000355734CKAP5chr11

46797805

-TMEM135chr11

86778736

+
5CDS-5UTRENST00000415402ENST00000535167CKAP5chr11

46797805

-TMEM135chr11

86778736

+
5CDS-5UTRENST00000529230ENST00000355734CKAP5chr11

46797805

-TMEM135chr11

86778736

+
5CDS-5UTRENST00000529230ENST00000535167CKAP5chr11

46797805

-TMEM135chr11

86778736

+
5CDS-intronENST00000312055ENST00000305494CKAP5chr11

46797805

-TMEM135chr11

86778736

+
5CDS-intronENST00000312055ENST00000532959CKAP5chr11

46797805

-TMEM135chr11

86778736

+
5CDS-intronENST00000354558ENST00000305494CKAP5chr11

46797805

-TMEM135chr11

86778736

+
5CDS-intronENST00000354558ENST00000532959CKAP5chr11

46797805

-TMEM135chr11

86778736

+
5CDS-intronENST00000415402ENST00000305494CKAP5chr11

46797805

-TMEM135chr11

86778736

+
5CDS-intronENST00000415402ENST00000532959CKAP5chr11

46797805

-TMEM135chr11

86778736

+
5CDS-intronENST00000529230ENST00000305494CKAP5chr11

46797805

-TMEM135chr11

86778736

+
5CDS-intronENST00000529230ENST00000532959CKAP5chr11

46797805

-TMEM135chr11

86778736

+
In-frameENST00000312055ENST00000340353CKAP5chr11

46797805

-TMEM135chr11

86778736

+
In-frameENST00000354558ENST00000340353CKAP5chr11

46797805

-TMEM135chr11

86778736

+
In-frameENST00000415402ENST00000340353CKAP5chr11

46797805

-TMEM135chr11

86778736

+
In-frameENST00000529230ENST00000340353CKAP5chr11

46797805

-TMEM135chr11

86778736

+
intron-3CDSENST00000532321ENST00000340353CKAP5chr11

46797805

-TMEM135chr11

86778736

+
intron-5UTRENST00000532321ENST00000355734CKAP5chr11

46797805

-TMEM135chr11

86778736

+
intron-5UTRENST00000532321ENST00000535167CKAP5chr11

46797805

-TMEM135chr11

86778736

+
intron-intronENST00000532321ENST00000305494CKAP5chr11

46797805

-TMEM135chr11

86778736

+
intron-intronENST00000532321ENST00000532959CKAP5chr11

46797805

-TMEM135chr11

86778736

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000529230CKAP5chr1146797805-ENST00000340353TMEM135chr1186778736+663330384742071386
ENST00000415402CKAP5chr1146797805-ENST00000340353TMEM135chr1186778736+6696310111042701386
ENST00000312055CKAP5chr1146797805-ENST00000340353TMEM135chr1186778736+6696310111042701386
ENST00000354558CKAP5chr1146797805-ENST00000340353TMEM135chr1186778736+661230172641861386

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000529230ENST00000340353CKAP5chr1146797805-TMEM135chr1186778736+0.0002246360.99977535
ENST00000415402ENST00000340353CKAP5chr1146797805-TMEM135chr1186778736+0.0002396310.9997603
ENST00000312055ENST00000340353CKAP5chr1146797805-TMEM135chr1186778736+0.0002396310.9997603
ENST00000354558ENST00000340353CKAP5chr1146797805-TMEM135chr1186778736+0.0002244580.9997756

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Fusion Genomic Features for CKAP5-TMEM135


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CKAP5chr1146797804-TMEM135chr1186778735+7.92E-050.99992085
CKAP5chr1146797804-TMEM135chr1186778735+7.92E-050.99992085
CKAP5chr1146797804-TMEM135chr1186778735+7.92E-050.99992085
CKAP5chr1146797804-TMEM135chr1186778735+7.92E-050.99992085
CKAP5chr1146797804-TMEM135chr1186778735+7.92E-050.99992085
CKAP5chr1146797804-TMEM135chr1186778735+7.92E-050.99992085

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CKAP5-TMEM135


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:46797805/chr11:86778736)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCKAP5chr11:46797805chr11:86778736ENST00000312055-24431_2239971973.0RegionTOG 1
HgeneCKAP5chr11:46797805chr11:86778736ENST00000312055-2443268_5029971973.0RegionTOG 2
HgeneCKAP5chr11:46797805chr11:86778736ENST00000312055-2443588_8179971973.0RegionTOG 3
HgeneCKAP5chr11:46797805chr11:86778736ENST00000354558-23421_2239971973.0RegionTOG 1
HgeneCKAP5chr11:46797805chr11:86778736ENST00000354558-2342268_5029971973.0RegionTOG 2
HgeneCKAP5chr11:46797805chr11:86778736ENST00000354558-2342588_8179971973.0RegionTOG 3
HgeneCKAP5chr11:46797805chr11:86778736ENST00000415402-24441_2239972040.0RegionTOG 1
HgeneCKAP5chr11:46797805chr11:86778736ENST00000415402-2444268_5029972040.0RegionTOG 2
HgeneCKAP5chr11:46797805chr11:86778736ENST00000415402-2444588_8179972040.0RegionTOG 3
HgeneCKAP5chr11:46797805chr11:86778736ENST00000529230-24441_2239972033.0RegionTOG 1
HgeneCKAP5chr11:46797805chr11:86778736ENST00000529230-2444268_5029972033.0RegionTOG 2
HgeneCKAP5chr11:46797805chr11:86778736ENST00000529230-2444588_8179972033.0RegionTOG 3
HgeneCKAP5chr11:46797805chr11:86778736ENST00000312055-2443159_1979971973.0RepeatNote=HEAT 1
HgeneCKAP5chr11:46797805chr11:86778736ENST00000312055-2443356_3949971973.0RepeatNote=HEAT 2
HgeneCKAP5chr11:46797805chr11:86778736ENST00000312055-2443434_4729971973.0RepeatNote=HEAT 3
HgeneCKAP5chr11:46797805chr11:86778736ENST00000312055-2443750_7889971973.0RepeatNote=HEAT 4
HgeneCKAP5chr11:46797805chr11:86778736ENST00000312055-2443855_8939971973.0RepeatNote=HEAT 5
HgeneCKAP5chr11:46797805chr11:86778736ENST00000312055-2443936_9749971973.0RepeatNote=HEAT 6
HgeneCKAP5chr11:46797805chr11:86778736ENST00000354558-2342159_1979971973.0RepeatNote=HEAT 1
HgeneCKAP5chr11:46797805chr11:86778736ENST00000354558-2342356_3949971973.0RepeatNote=HEAT 2
HgeneCKAP5chr11:46797805chr11:86778736ENST00000354558-2342434_4729971973.0RepeatNote=HEAT 3
HgeneCKAP5chr11:46797805chr11:86778736ENST00000354558-2342750_7889971973.0RepeatNote=HEAT 4
HgeneCKAP5chr11:46797805chr11:86778736ENST00000354558-2342855_8939971973.0RepeatNote=HEAT 5
HgeneCKAP5chr11:46797805chr11:86778736ENST00000354558-2342936_9749971973.0RepeatNote=HEAT 6
HgeneCKAP5chr11:46797805chr11:86778736ENST00000415402-2444159_1979972040.0RepeatNote=HEAT 1
HgeneCKAP5chr11:46797805chr11:86778736ENST00000415402-2444356_3949972040.0RepeatNote=HEAT 2
HgeneCKAP5chr11:46797805chr11:86778736ENST00000415402-2444434_4729972040.0RepeatNote=HEAT 3
HgeneCKAP5chr11:46797805chr11:86778736ENST00000415402-2444750_7889972040.0RepeatNote=HEAT 4
HgeneCKAP5chr11:46797805chr11:86778736ENST00000415402-2444855_8939972040.0RepeatNote=HEAT 5
HgeneCKAP5chr11:46797805chr11:86778736ENST00000415402-2444936_9749972040.0RepeatNote=HEAT 6
HgeneCKAP5chr11:46797805chr11:86778736ENST00000529230-2444159_1979972033.0RepeatNote=HEAT 1
HgeneCKAP5chr11:46797805chr11:86778736ENST00000529230-2444356_3949972033.0RepeatNote=HEAT 2
HgeneCKAP5chr11:46797805chr11:86778736ENST00000529230-2444434_4729972033.0RepeatNote=HEAT 3
HgeneCKAP5chr11:46797805chr11:86778736ENST00000529230-2444750_7889972033.0RepeatNote=HEAT 4
HgeneCKAP5chr11:46797805chr11:86778736ENST00000529230-2444855_8939972033.0RepeatNote=HEAT 5
HgeneCKAP5chr11:46797805chr11:86778736ENST00000529230-2444936_9749972033.0RepeatNote=HEAT 6
TgeneTMEM135chr11:46797805chr11:86778736ENST00000305494015149_16947459.0TransmembraneHelical
TgeneTMEM135chr11:46797805chr11:86778736ENST00000305494015298_31847459.0TransmembraneHelical
TgeneTMEM135chr11:46797805chr11:86778736ENST00000305494015331_35147459.0TransmembraneHelical
TgeneTMEM135chr11:46797805chr11:86778736ENST00000305494015380_40047459.0TransmembraneHelical
TgeneTMEM135chr11:46797805chr11:86778736ENST0000030549401568_8847459.0TransmembraneHelical
TgeneTMEM135chr11:46797805chr11:86778736ENST0000030549401596_11647459.0TransmembraneHelical
TgeneTMEM135chr11:46797805chr11:86778736ENST00000340353014149_16947437.0TransmembraneHelical
TgeneTMEM135chr11:46797805chr11:86778736ENST00000340353014298_31847437.0TransmembraneHelical
TgeneTMEM135chr11:46797805chr11:86778736ENST00000340353014331_35147437.0TransmembraneHelical
TgeneTMEM135chr11:46797805chr11:86778736ENST00000340353014380_40047437.0TransmembraneHelical
TgeneTMEM135chr11:46797805chr11:86778736ENST0000034035301468_8847437.0TransmembraneHelical
TgeneTMEM135chr11:46797805chr11:86778736ENST0000034035301496_11647437.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCKAP5chr11:46797805chr11:86778736ENST00000312055-24431193_14289971973.0RegionTOG 5
HgeneCKAP5chr11:46797805chr11:86778736ENST00000312055-2443853_10819971973.0RegionTOG 4
HgeneCKAP5chr11:46797805chr11:86778736ENST00000354558-23421193_14289971973.0RegionTOG 5
HgeneCKAP5chr11:46797805chr11:86778736ENST00000354558-2342853_10819971973.0RegionTOG 4
HgeneCKAP5chr11:46797805chr11:86778736ENST00000415402-24441193_14289972040.0RegionTOG 5
HgeneCKAP5chr11:46797805chr11:86778736ENST00000415402-2444853_10819972040.0RegionTOG 4
HgeneCKAP5chr11:46797805chr11:86778736ENST00000529230-24441193_14289972033.0RegionTOG 5
HgeneCKAP5chr11:46797805chr11:86778736ENST00000529230-2444853_10819972033.0RegionTOG 4
HgeneCKAP5chr11:46797805chr11:86778736ENST00000312055-24431013_10519971973.0RepeatNote=HEAT 7
HgeneCKAP5chr11:46797805chr11:86778736ENST00000312055-24431284_13229971973.0RepeatNote=HEAT 8
HgeneCKAP5chr11:46797805chr11:86778736ENST00000312055-24431324_13579971973.0RepeatNote=HEAT 9
HgeneCKAP5chr11:46797805chr11:86778736ENST00000312055-24431361_13999971973.0RepeatNote=HEAT 10
HgeneCKAP5chr11:46797805chr11:86778736ENST00000354558-23421013_10519971973.0RepeatNote=HEAT 7
HgeneCKAP5chr11:46797805chr11:86778736ENST00000354558-23421284_13229971973.0RepeatNote=HEAT 8
HgeneCKAP5chr11:46797805chr11:86778736ENST00000354558-23421324_13579971973.0RepeatNote=HEAT 9
HgeneCKAP5chr11:46797805chr11:86778736ENST00000354558-23421361_13999971973.0RepeatNote=HEAT 10
HgeneCKAP5chr11:46797805chr11:86778736ENST00000415402-24441013_10519972040.0RepeatNote=HEAT 7
HgeneCKAP5chr11:46797805chr11:86778736ENST00000415402-24441284_13229972040.0RepeatNote=HEAT 8
HgeneCKAP5chr11:46797805chr11:86778736ENST00000415402-24441324_13579972040.0RepeatNote=HEAT 9
HgeneCKAP5chr11:46797805chr11:86778736ENST00000415402-24441361_13999972040.0RepeatNote=HEAT 10
HgeneCKAP5chr11:46797805chr11:86778736ENST00000529230-24441013_10519972033.0RepeatNote=HEAT 7
HgeneCKAP5chr11:46797805chr11:86778736ENST00000529230-24441284_13229972033.0RepeatNote=HEAT 8
HgeneCKAP5chr11:46797805chr11:86778736ENST00000529230-24441324_13579972033.0RepeatNote=HEAT 9
HgeneCKAP5chr11:46797805chr11:86778736ENST00000529230-24441361_13999972033.0RepeatNote=HEAT 10


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Fusion Gene Sequence for CKAP5-TMEM135


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>16898_16898_1_CKAP5-TMEM135_CKAP5_chr11_46797805_ENST00000312055_TMEM135_chr11_86778736_ENST00000340353_length(transcript)=6696nt_BP=3101nt
ACTGCGGGGTGTGCGGCGGCCCAAGCGGTTTCAAACGGCTTAGAGCAGGCCGCTTGGTTCTGACCCAGCTGAGGAAATACTCTTAATTCT
AAGGAAAACCTGGAAGCACAATGGGAGATGACAGTGAGTGGTTGAAACTGCCAGTTGATCAGAAATGTGAACACAAGCTGTGGAAAGCAA
GGTTAAGTGGGTATGAAGAGGCCCTGAAGATCTTCCAGAAAATAAAGGATGAAAAGAGCCCAGAGTGGTCCAAATTTTTAGGATTGATCA
AAAAATTTGTCACTGATTCCAATGCAGTGGTTCAATTGAAAGGATTAGAAGCTGCACTTGTTTATGTTGAAAATGCCCATGTAGCAGGAA
AAACCACAGGAGAAGTTGTGTCAGGTGTTGTAAGTAAGGTGTTCAATCAACCTAAAGCTAAAGCCAAGGAGCTGGGCATAGAGATCTGTC
TTATGTACATAGAGATTGAGAAAGGAGAGGCTGTTCAAGAAGAGCTCCTGAAAGGCTTGGACAATAAGAATCCCAAGATCATAGTGGCCT
GTATAGAGACACTGAGGAAAGCCTTAAGTGAATTTGGTTCCAAAATCATCTTGCTTAAGCCAATTATCAAAGTGTTGCCAAAACTCTTTG
AGTCTCGAGAGAAGGCTGTTCGAGATGAAGCCAAACTAATTGCTGTGGAGATTTACAGATGGATTCGGGATGCTCTGAGACCCCCATTAC
AAAATATAAACTCTGTTCAGTTGAAAGAACTAGAAGAAGAATGGGTCAAACTGCCAACAAGTGCTCCTAGACCTACTCGATTTCTTCGTT
CCCAACAAGAACTAGAAGCTAAATTGGAACAACAACAGTCTGCTGGTGGAGATGCTGAAGGAGGTGGTGATGATGGTGATGAGGTGCCAC
AAATAGATGCTTATGAGCTTTTAGAAGCTGTAGAAATCCTTTCCAAACTTCCCAAAGACTTTTATGACAAAATTGAGGCAAAAAAATGGC
AAGAGAGAAAAGAGGCCCTGGAGTCTGTAGAAGTACTAATAAAAAACCCCAAACTGGAAGCTGGCGATTATGCAGATTTAGTAAAAGCAT
TAAAGAAGGTTGTTGGAAAGGACACCAATGTCATGTTGGTGGCTTTGGCAGCAAAATGTCTTACTGGCCTGGCTGTTGGGCTAAGGAAGA
AATTTGGACAATATGCAGGACATGTTGTGCCAACCATCTTGGAGAAATTCAAAGAGAAGAAACCTCAAGTGGTACAAGCCCTGCAGGAGG
CAATTGATGCAATCTTCCTTACTACCACACTACAGAACATCAGTGAGGATGTTTTAGCAGTAATGGATAATAAAAATCCAACCATCAAGC
AGCAGACATCTCTTTTTATTGCAAGAAGTTTCCGCCACTGCACTGCTTCTACCCTGCCAAAGAGCTTGCTAAAGCCCTTTTGTGCTGCAC
TACTTAAGCACATCAATGATTCTGCTCCTGAAGTCAGAGATGCCGCATTTGAAGCATTGGGTACTGCTTTGAAGGTGGTTGGCGAGAAAG
CAGTAAACCCATTCCTAGCTGATGTGGACAAACTCAAGCTTGATAAGATCAAAGAATGTTCAGAAAAGGTAGAACTGATACATGGTAAGA
AAGCTGGACTAGCTGCTGATAAGAAGGAATTCAAACCTCTGCCTGGAAGGACTGCTGCTTCAGGGGCTGCAGGAGATAAGGACACAAAGG
ACATTTCTGCACCCAAACCAGGACCTCTAAAAAAGGCACCTGCTGCTAAGGCTGGTGGGCCACCAAAAAAGGGGAAACCAGCTGCACCAG
GAGGCGCAGGGAATACTGGAACCAAGAACAAGAAAGGACTGGAGACTAAAGAAATAGTGGAGCCTGAGCTCTCGATAGAAGTATGTGAAG
AAAAAGCTTCAGCTGTTCTTCCCCCTACCTGTATACAGCTTCTTGACAGCAGTAACTGGAAAGAAAGGCTGGCTTGTATGGAAGAGTTCC
AGAAGGCTGTTGAGCTAATGGACCGAACTGAAATGCCATGCCAGGCATTAGTGAGGATGCTAGCCAAGAAACCTGGATGGAAAGAAACTA
ATTTTCAGGTGATGCAAATGAAGCTTCATATAGTTGCTTTGATTGCCCAGAAGGGAAATTTTTCCAAAACGTCAGCTCAGGTTGTATTAG
ATGGCCTTGTGGACAAGATTGGAGATGTGAAATGTGGGAACAATGCAAAAGAAGCTATGACAGCAATAGCCGAAGCCTGTATGTTACCAT
GGACTGCTGAACAGGTTGTGTCAATGGCTTTCTCACAAAAGAATCCCAAAAATCAGTCAGAAACTCTGAATTGGCTATCAAATGCCATAA
AAGAATTTGGTTTTTCTGGGTTGAATGTCAAAGCTTTCATTAGCAATGTGAAGACAGCTCTTGCTGCAACAAACCCAGCTGTGAGGACTG
CTGCCATAACCCTGCTTGGCGTGATGTATCTGTATGTTGGTCCCTCTTTGCGAATGTTCTTTGAGGATGAGAAGCCTGCCCTCCTATCCC
AGATAGATGCAGAATTTGAGAAGATGCAGGGACAAAGTCCACCTGCTCCAACCAGAGGAATTTCCAAGCATAGCACAAGTGGTACAGATG
AAGGAGAAGATGGAGATGAACCAGATGACGGGAGCAATGATGTCGTTGATCTTTTGCCGAGGACGGAGATCAGTGATAAAATCACTTCAG
AGTTGGTATCTAAGATTGGTGATAAGAATTGGAAGATTAGGAAAGAAGGCCTAGATGAAGTGGCAGGTATTATTAATGACGCAAAATTTA
TCCAACCGAATATAGGTGAACTTCCAACTGCCTTGAAGGGTCGACTCAATGATTCAAATAAAATCTTGGTACAGCAAACGCTGAATATCC
TGCAACAACTGGCAGTAGCCATGGGCCCAAATATTAAGCAACATGTAAAAAATTTAGGCATCCCTATCATCACAGTCCTTGGAGACAGCA
AGAACAATGTTCGAGCTGCTGCCCTAGCGACTGTGAATGCTTGGGCAGAACAGACTGGCATGAAGGAATGGCTGGAAGGAGAAGATCTTT
CTGAAGAGCTCAAAAAGGAAAATCCTTTCTTGAGGCAAGAGATTGCAGCAATTCTCCGGAAACGGAAATTAGACTATTATTTACACAAAC
TACTCCCTGAGATCCTACAATCCGCTTCATTTCTAACTGCTAATGGGGCCTTGTATATGGCTTTCTTTTGCATTTTAAGGAAGATACTTG
GAAAATTCTACTCATGGACTCCTGGCTTTGGTGCCGCTCTGCCAGCATCTTATGTGGCCATTCTCATTGAAAGAAAAAGCAGGAGAGGGC
TGCTCACAATTTATATGGCCAACTTGGTCCTTTTGTTTTGCATCACAGCTGCCATGTACATGTTCTTTTTCAGGTGCAAGGATGGCTTGA
AAGGATTTACATTTTCTGCACTTAGGTTCATTGTAGGGAAGGAAGAAATTCCCACACATTCTTTTTCACCAGAGGCAGCATATGCAAAAG
TGGAACAAAAGAGAGAGCAACATGAGGAAAAACCCGGAAGAATGAATATGATTGGTCTAGTCAGGAAATTTGTGGATTCAATATGCAAAC
ATGGACCAAGGCATAGATGTTGCAAACATTATGAAGATAATTGCATCTCTTATTGCATTAAAGGTTTCATCAGAATGTTTAGCGTGGGGT
ACTTGATCCAGTGCTGCCTCCGAATCCCTTCTGCATTTAGGCATCTGTTTACACAGCCATCTCGGCTACTTTCTCTCTTCTACAATAAAG
AAAACTTCCAGCTTGGAGCTTTTCTTGGCTCTTTTGTTAGTATATACAAGGGTACTAGTTGCTTCCTGCGCTGGATCAGAAACTTAGATG
ATGAACTACATGCTATTATAGCTGGATTTTTGGCAGGTATATCAATGATGTTTTATAAAAGCACAACAATTTCCATGTATTTAGCGTCCA
AATTGGTAGAGACAATGTATTTCAAAGGCATTGAAGCAGGGAAGGTTCCCTATTTTCCTCATGCAGATACTATCATCTATTCCATCTCTA
CAGCAATTTGCTTCCAGGCAGCTGTCATGGAAGTTCAGACTTTGAGACCATCTTACTGGAAGTTCCTTTTAAGACTCACCAAGGGCAAAT
TTGCTGTCATGAACCGAAAAGTCCTTGATGTTTTTGGTACTGGTGCATCTAAACACTTTCAGGATTTCATCCCCAGGTTGGATCCAAGAT
ACACAACTGTAACACCAGAGTTGCCCACAGAGTTTTCCTGAAGATGACTGTAACTTATTAATGTGACTAAATGTTTCATCTTGAAGAGTT
AATTATGTTGAACACAAAGGAGGGGGCCCAAGCTCGAACTTCAGTGTTATTTCAGTTAGAGATACTCTTTTCATTTGTTTTGTTTTTCTT
ATGAATCAGAAATTCAGAAGCTTTTTAGGAAGATGTTGCTTAATAATTAAGCTTCCTCCATAGCCAGAATAAGATTCTGGATCACTGTAG
TGACTGACATTATATATTATTGATCAAATTATGTCCACAAGCAATATTATATAATCTACGTAGAAGTGTAATAACAAACAAGAGTACACT
TAAAATTACTTTAAAAGATGTCTTTAGTTCATTCCAATATAATTCTTGATTAAAATTAGGATTATTTCTACATTTTAGGATTTACAAAGG
ATCACGGGTACATGGATTTGGTCTATATATTTTTTTAAAGTTTTGAATTGGTATCTGTAGTAGTGGAATGTTATAGATTTGAAGTAACTC
TCCACGGACAGTGCTGCTTTCGTGTAGAGCAATTTAATTGGAGAAGTGGCCATTCTTACTTCAGGGATGCAAAGATGGGTCTCATACCAT
TTGGATAAATGTCGTGGTATCCATGCTTTTTTTCAACTAATAACATCATCTCTCTTCATGACCAGTTAATTGGGCTATTTGGCAGCCCAG
TGAACCTATGTACTAATGGCAAGTTAGGGGCAAATGGAAATGGACACATCCGATAAAGTTGAAATGTATGTTTTAATCTTTCACAGAAGT
ATTACACTTGAATATTTAAAAACAAAACTTTTAAACTTCCTATAGGTTTATGATGTTTGTTTTCATTTATATGGACATAATCCTTCATAG
CTCAGTTTATATGCCATTGTTGTATTAGAAGGGATCAAAATCCTATGGAACAAAGTAGTCTTGGCAAGTTGGCAGTTTGTGTCCTCTCAG
CTGTTTAACTTATGTAATGGATGTTTTGCACCTGAAAACACTATAAAAATCCAGTGGTTGTTTAAAAAGTCCATTTGTCACTAATTCCAT
TCAGGTTCTCCAACCTTCTTCTTGAATATCATTGTCACCATTTTTACTGTTAGAATAAAGAGGTGACACCATAAAGTCCTGCTGATAATG
AGAGTAGTTCAGGACAGCTGTGATTGAAATATGGTCGCTATTTACAGTTTTTCAGGGAAAAGTTATACTTTTCTATGTTAATAAAGAGCT
GAAGTGGTCTACAGTTAATGTGACATGTAGGGATGATGATATTTTTAAAATACATTTTGTTGCTAAAAAGTTTTTAGGCCAGTGCAAATT
ATGCAGTAGAACTTGTGTTGCAAAAGGAATTATAACCCATACTTTAAAAATGCTTAATCCCTCATATTCAATTTCATCAAGCCTTGTATA
CTTCTGCTTAAATGTAATTCAATCCTTGGTTGTTATGGCAAACAGAAACCCAACAAAAAGACAGACTCTGGTACTATGGTAACAGAGCCA
CTTTATCATTTGGTCAAAATTTGGCATTATGATTAGCTTTGTAGAACTGACCTGTTTATTTGGCAATGCTGTTAAAGGATCATTTCGGTT
TCAGACTTCAAAGTTGATTAATAAATTTAATCTTAACTTTTTATTCACTGGAATCAAAACGATGGTTGGTACTGTGTTTACTGTTTAAAA
TGAAGTACTAAAGCCCTGAGAACTGCACCTCATTTTCTTTATCCAGAAATTGTGCTTATATATTTTCCTGTCAGGTTTAAAAAGATGTTT
TAATTCATAAATTATTGTTTTCATTGACATTAAAAGACTGTGATATTGAAAGATGAATTACGAAATTTGCTGAGATTGTTTAGTAAAATT
TTGCTGGTCAAAAAGGTGTATTTCTACAATTTACCTTTTCATTTTTATAAATTGCAGTCATTTTTTTAAATTTTATGTAAAATGTAAAAT
GAAATAGCTATCATGAAGCAGAATACAATGATGAATGTATAGGTTGAGTGAATAACCAATTTGCAGTGGTGGATTGAGAAGTCCAGTTTG
ATTTCATTGGGACAGACTGCAAAGTGTAGTTGTTTGAGCAAACACAAAGAAACTTTGTGTTTTTGAAGACAATCAGAATGATTACCTTTC
TACCTCTAACTAATCAGGTATTGATTGACAACTTTTTGGCATTATAAATAAAGTAAAATAGATCTCTGCATTCCAAAATATGTTTTTTAG
TTTATTTATATCCTGAAGAAATGGTAAGTTTTCACTGGAACTGATTACAGTAAACAATAATATGTCCCCTTAGTCTTTCTGACATTTTTA
TATAGATTGAGATTGAAAAACCGTGCATTTGGGGCAGTGGTATTATGGTCATTTCGTTGCTATTTTCTGTTTTAATAAAATCCTAGAACT

>16898_16898_1_CKAP5-TMEM135_CKAP5_chr11_46797805_ENST00000312055_TMEM135_chr11_86778736_ENST00000340353_length(amino acids)=1386AA_BP=997
MGDDSEWLKLPVDQKCEHKLWKARLSGYEEALKIFQKIKDEKSPEWSKFLGLIKKFVTDSNAVVQLKGLEAALVYVENAHVAGKTTGEVV
SGVVSKVFNQPKAKAKELGIEICLMYIEIEKGEAVQEELLKGLDNKNPKIIVACIETLRKALSEFGSKIILLKPIIKVLPKLFESREKAV
RDEAKLIAVEIYRWIRDALRPPLQNINSVQLKELEEEWVKLPTSAPRPTRFLRSQQELEAKLEQQQSAGGDAEGGGDDGDEVPQIDAYEL
LEAVEILSKLPKDFYDKIEAKKWQERKEALESVEVLIKNPKLEAGDYADLVKALKKVVGKDTNVMLVALAAKCLTGLAVGLRKKFGQYAG
HVVPTILEKFKEKKPQVVQALQEAIDAIFLTTTLQNISEDVLAVMDNKNPTIKQQTSLFIARSFRHCTASTLPKSLLKPFCAALLKHIND
SAPEVRDAAFEALGTALKVVGEKAVNPFLADVDKLKLDKIKECSEKVELIHGKKAGLAADKKEFKPLPGRTAASGAAGDKDTKDISAPKP
GPLKKAPAAKAGGPPKKGKPAAPGGAGNTGTKNKKGLETKEIVEPELSIEVCEEKASAVLPPTCIQLLDSSNWKERLACMEEFQKAVELM
DRTEMPCQALVRMLAKKPGWKETNFQVMQMKLHIVALIAQKGNFSKTSAQVVLDGLVDKIGDVKCGNNAKEAMTAIAEACMLPWTAEQVV
SMAFSQKNPKNQSETLNWLSNAIKEFGFSGLNVKAFISNVKTALAATNPAVRTAAITLLGVMYLYVGPSLRMFFEDEKPALLSQIDAEFE
KMQGQSPPAPTRGISKHSTSGTDEGEDGDEPDDGSNDVVDLLPRTEISDKITSELVSKIGDKNWKIRKEGLDEVAGIINDAKFIQPNIGE
LPTALKGRLNDSNKILVQQTLNILQQLAVAMGPNIKQHVKNLGIPIITVLGDSKNNVRAAALATVNAWAEQTGMKEWLEGEDLSEELKKE
NPFLRQEIAAILRKRKLDYYLHKLLPEILQSASFLTANGALYMAFFCILRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLTIYMA
NLVLLFCITAAMYMFFFRCKDGLKGFTFSALRFIVGKEEIPTHSFSPEAAYAKVEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRC
CKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAII
AGFLAGISMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGKFAVMNRK

--------------------------------------------------------------
>16898_16898_2_CKAP5-TMEM135_CKAP5_chr11_46797805_ENST00000354558_TMEM135_chr11_86778736_ENST00000340353_length(transcript)=6612nt_BP=3017nt
AATTCTAAGGAAAACCTGGAAGCACAATGGGAGATGACAGTGAGTGGTTGAAACTGCCAGTTGATCAGAAATGTGAACACAAGCTGTGGA
AAGCAAGGTTAAGTGGGTATGAAGAGGCCCTGAAGATCTTCCAGAAAATAAAGGATGAAAAGAGCCCAGAGTGGTCCAAATTTTTAGGAT
TGATCAAAAAATTTGTCACTGATTCCAATGCAGTGGTTCAATTGAAAGGATTAGAAGCTGCACTTGTTTATGTTGAAAATGCCCATGTAG
CAGGAAAAACCACAGGAGAAGTTGTGTCAGGTGTTGTAAGTAAGGTGTTCAATCAACCTAAAGCTAAAGCCAAGGAGCTGGGCATAGAGA
TCTGTCTTATGTACATAGAGATTGAGAAAGGAGAGGCTGTTCAAGAAGAGCTCCTGAAAGGCTTGGACAATAAGAATCCCAAGATCATAG
TGGCCTGTATAGAGACACTGAGGAAAGCCTTAAGTGAATTTGGTTCCAAAATCATCTTGCTTAAGCCAATTATCAAAGTGTTGCCAAAAC
TCTTTGAGTCTCGAGAGAAGGCTGTTCGAGATGAAGCCAAACTAATTGCTGTGGAGATTTACAGATGGATTCGGGATGCTCTGAGACCCC
CATTACAAAATATAAACTCTGTTCAGTTGAAAGAACTAGAAGAAGAATGGGTCAAACTGCCAACAAGTGCTCCTAGACCTACTCGATTTC
TTCGTTCCCAACAAGAACTAGAAGCTAAATTGGAACAACAACAGTCTGCTGGTGGAGATGCTGAAGGAGGTGGTGATGATGGTGATGAGG
TGCCACAAATAGATGCTTATGAGCTTTTAGAAGCTGTAGAAATCCTTTCCAAACTTCCCAAAGACTTTTATGACAAAATTGAGGCAAAAA
AATGGCAAGAGAGAAAAGAGGCCCTGGAGTCTGTAGAAGTACTAATAAAAAACCCCAAACTGGAAGCTGGCGATTATGCAGATTTAGTAA
AAGCATTAAAGAAGGTTGTTGGAAAGGACACCAATGTCATGTTGGTGGCTTTGGCAGCAAAATGTCTTACTGGCCTGGCTGTTGGGCTAA
GGAAGAAATTTGGACAATATGCAGGACATGTTGTGCCAACCATCTTGGAGAAATTCAAAGAGAAGAAACCTCAAGTGGTACAAGCCCTGC
AGGAGGCAATTGATGCAATCTTCCTTACTACCACACTACAGAACATCAGTGAGGATGTTTTAGCAGTAATGGATAATAAAAATCCAACCA
TCAAGCAGCAGACATCTCTTTTTATTGCAAGAAGTTTCCGCCACTGCACTGCTTCTACCCTGCCAAAGAGCTTGCTAAAGCCCTTTTGTG
CTGCACTACTTAAGCACATCAATGATTCTGCTCCTGAAGTCAGAGATGCCGCATTTGAAGCATTGGGTACTGCTTTGAAGGTGGTTGGCG
AGAAAGCAGTAAACCCATTCCTAGCTGATGTGGACAAACTCAAGCTTGATAAGATCAAAGAATGTTCAGAAAAGGTAGAACTGATACATG
GTAAGAAAGCTGGACTAGCTGCTGATAAGAAGGAATTCAAACCTCTGCCTGGAAGGACTGCTGCTTCAGGGGCTGCAGGAGATAAGGACA
CAAAGGACATTTCTGCACCCAAACCAGGACCTCTAAAAAAGGCACCTGCTGCTAAGGCTGGTGGGCCACCAAAAAAGGGGAAACCAGCTG
CACCAGGAGGCGCAGGGAATACTGGAACCAAGAACAAGAAAGGACTGGAGACTAAAGAAATAGTGGAGCCTGAGCTCTCGATAGAAGTAT
GTGAAGAAAAAGCTTCAGCTGTTCTTCCCCCTACCTGTATACAGCTTCTTGACAGCAGTAACTGGAAAGAAAGGCTGGCTTGTATGGAAG
AGTTCCAGAAGGCTGTTGAGCTAATGGACCGAACTGAAATGCCATGCCAGGCATTAGTGAGGATGCTAGCCAAGAAACCTGGATGGAAAG
AAACTAATTTTCAGGTGATGCAAATGAAGCTTCATATAGTTGCTTTGATTGCCCAGAAGGGAAATTTTTCCAAAACGTCAGCTCAGGTTG
TATTAGATGGCCTTGTGGACAAGATTGGAGATGTGAAATGTGGGAACAATGCAAAAGAAGCTATGACAGCAATAGCCGAAGCCTGTATGT
TACCATGGACTGCTGAACAGGTTGTGTCAATGGCTTTCTCACAAAAGAATCCCAAAAATCAGTCAGAAACTCTGAATTGGCTATCAAATG
CCATAAAAGAATTTGGTTTTTCTGGGTTGAATGTCAAAGCTTTCATTAGCAATGTGAAGACAGCTCTTGCTGCAACAAACCCAGCTGTGA
GGACTGCTGCCATAACCCTGCTTGGCGTGATGTATCTGTATGTTGGTCCCTCTTTGCGAATGTTCTTTGAGGATGAGAAGCCTGCCCTCC
TATCCCAGATAGATGCAGAATTTGAGAAGATGCAGGGACAAAGTCCACCTGCTCCAACCAGAGGAATTTCCAAGCATAGCACAAGTGGTA
CAGATGAAGGAGAAGATGGAGATGAACCAGATGACGGGAGCAATGATGTCGTTGATCTTTTGCCGAGGACGGAGATCAGTGATAAAATCA
CTTCAGAGTTGGTATCTAAGATTGGTGATAAGAATTGGAAGATTAGGAAAGAAGGCCTAGATGAAGTGGCAGGTATTATTAATGACGCAA
AATTTATCCAACCGAATATAGGTGAACTTCCAACTGCCTTGAAGGGTCGACTCAATGATTCAAATAAAATCTTGGTACAGCAAACGCTGA
ATATCCTGCAACAACTGGCAGTAGCCATGGGCCCAAATATTAAGCAACATGTAAAAAATTTAGGCATCCCTATCATCACAGTCCTTGGAG
ACAGCAAGAACAATGTTCGAGCTGCTGCCCTAGCGACTGTGAATGCTTGGGCAGAACAGACTGGCATGAAGGAATGGCTGGAAGGAGAAG
ATCTTTCTGAAGAGCTCAAAAAGGAAAATCCTTTCTTGAGGCAAGAGATTGCAGCAATTCTCCGGAAACGGAAATTAGACTATTATTTAC
ACAAACTACTCCCTGAGATCCTACAATCCGCTTCATTTCTAACTGCTAATGGGGCCTTGTATATGGCTTTCTTTTGCATTTTAAGGAAGA
TACTTGGAAAATTCTACTCATGGACTCCTGGCTTTGGTGCCGCTCTGCCAGCATCTTATGTGGCCATTCTCATTGAAAGAAAAAGCAGGA
GAGGGCTGCTCACAATTTATATGGCCAACTTGGTCCTTTTGTTTTGCATCACAGCTGCCATGTACATGTTCTTTTTCAGGTGCAAGGATG
GCTTGAAAGGATTTACATTTTCTGCACTTAGGTTCATTGTAGGGAAGGAAGAAATTCCCACACATTCTTTTTCACCAGAGGCAGCATATG
CAAAAGTGGAACAAAAGAGAGAGCAACATGAGGAAAAACCCGGAAGAATGAATATGATTGGTCTAGTCAGGAAATTTGTGGATTCAATAT
GCAAACATGGACCAAGGCATAGATGTTGCAAACATTATGAAGATAATTGCATCTCTTATTGCATTAAAGGTTTCATCAGAATGTTTAGCG
TGGGGTACTTGATCCAGTGCTGCCTCCGAATCCCTTCTGCATTTAGGCATCTGTTTACACAGCCATCTCGGCTACTTTCTCTCTTCTACA
ATAAAGAAAACTTCCAGCTTGGAGCTTTTCTTGGCTCTTTTGTTAGTATATACAAGGGTACTAGTTGCTTCCTGCGCTGGATCAGAAACT
TAGATGATGAACTACATGCTATTATAGCTGGATTTTTGGCAGGTATATCAATGATGTTTTATAAAAGCACAACAATTTCCATGTATTTAG
CGTCCAAATTGGTAGAGACAATGTATTTCAAAGGCATTGAAGCAGGGAAGGTTCCCTATTTTCCTCATGCAGATACTATCATCTATTCCA
TCTCTACAGCAATTTGCTTCCAGGCAGCTGTCATGGAAGTTCAGACTTTGAGACCATCTTACTGGAAGTTCCTTTTAAGACTCACCAAGG
GCAAATTTGCTGTCATGAACCGAAAAGTCCTTGATGTTTTTGGTACTGGTGCATCTAAACACTTTCAGGATTTCATCCCCAGGTTGGATC
CAAGATACACAACTGTAACACCAGAGTTGCCCACAGAGTTTTCCTGAAGATGACTGTAACTTATTAATGTGACTAAATGTTTCATCTTGA
AGAGTTAATTATGTTGAACACAAAGGAGGGGGCCCAAGCTCGAACTTCAGTGTTATTTCAGTTAGAGATACTCTTTTCATTTGTTTTGTT
TTTCTTATGAATCAGAAATTCAGAAGCTTTTTAGGAAGATGTTGCTTAATAATTAAGCTTCCTCCATAGCCAGAATAAGATTCTGGATCA
CTGTAGTGACTGACATTATATATTATTGATCAAATTATGTCCACAAGCAATATTATATAATCTACGTAGAAGTGTAATAACAAACAAGAG
TACACTTAAAATTACTTTAAAAGATGTCTTTAGTTCATTCCAATATAATTCTTGATTAAAATTAGGATTATTTCTACATTTTAGGATTTA
CAAAGGATCACGGGTACATGGATTTGGTCTATATATTTTTTTAAAGTTTTGAATTGGTATCTGTAGTAGTGGAATGTTATAGATTTGAAG
TAACTCTCCACGGACAGTGCTGCTTTCGTGTAGAGCAATTTAATTGGAGAAGTGGCCATTCTTACTTCAGGGATGCAAAGATGGGTCTCA
TACCATTTGGATAAATGTCGTGGTATCCATGCTTTTTTTCAACTAATAACATCATCTCTCTTCATGACCAGTTAATTGGGCTATTTGGCA
GCCCAGTGAACCTATGTACTAATGGCAAGTTAGGGGCAAATGGAAATGGACACATCCGATAAAGTTGAAATGTATGTTTTAATCTTTCAC
AGAAGTATTACACTTGAATATTTAAAAACAAAACTTTTAAACTTCCTATAGGTTTATGATGTTTGTTTTCATTTATATGGACATAATCCT
TCATAGCTCAGTTTATATGCCATTGTTGTATTAGAAGGGATCAAAATCCTATGGAACAAAGTAGTCTTGGCAAGTTGGCAGTTTGTGTCC
TCTCAGCTGTTTAACTTATGTAATGGATGTTTTGCACCTGAAAACACTATAAAAATCCAGTGGTTGTTTAAAAAGTCCATTTGTCACTAA
TTCCATTCAGGTTCTCCAACCTTCTTCTTGAATATCATTGTCACCATTTTTACTGTTAGAATAAAGAGGTGACACCATAAAGTCCTGCTG
ATAATGAGAGTAGTTCAGGACAGCTGTGATTGAAATATGGTCGCTATTTACAGTTTTTCAGGGAAAAGTTATACTTTTCTATGTTAATAA
AGAGCTGAAGTGGTCTACAGTTAATGTGACATGTAGGGATGATGATATTTTTAAAATACATTTTGTTGCTAAAAAGTTTTTAGGCCAGTG
CAAATTATGCAGTAGAACTTGTGTTGCAAAAGGAATTATAACCCATACTTTAAAAATGCTTAATCCCTCATATTCAATTTCATCAAGCCT
TGTATACTTCTGCTTAAATGTAATTCAATCCTTGGTTGTTATGGCAAACAGAAACCCAACAAAAAGACAGACTCTGGTACTATGGTAACA
GAGCCACTTTATCATTTGGTCAAAATTTGGCATTATGATTAGCTTTGTAGAACTGACCTGTTTATTTGGCAATGCTGTTAAAGGATCATT
TCGGTTTCAGACTTCAAAGTTGATTAATAAATTTAATCTTAACTTTTTATTCACTGGAATCAAAACGATGGTTGGTACTGTGTTTACTGT
TTAAAATGAAGTACTAAAGCCCTGAGAACTGCACCTCATTTTCTTTATCCAGAAATTGTGCTTATATATTTTCCTGTCAGGTTTAAAAAG
ATGTTTTAATTCATAAATTATTGTTTTCATTGACATTAAAAGACTGTGATATTGAAAGATGAATTACGAAATTTGCTGAGATTGTTTAGT
AAAATTTTGCTGGTCAAAAAGGTGTATTTCTACAATTTACCTTTTCATTTTTATAAATTGCAGTCATTTTTTTAAATTTTATGTAAAATG
TAAAATGAAATAGCTATCATGAAGCAGAATACAATGATGAATGTATAGGTTGAGTGAATAACCAATTTGCAGTGGTGGATTGAGAAGTCC
AGTTTGATTTCATTGGGACAGACTGCAAAGTGTAGTTGTTTGAGCAAACACAAAGAAACTTTGTGTTTTTGAAGACAATCAGAATGATTA
CCTTTCTACCTCTAACTAATCAGGTATTGATTGACAACTTTTTGGCATTATAAATAAAGTAAAATAGATCTCTGCATTCCAAAATATGTT
TTTTAGTTTATTTATATCCTGAAGAAATGGTAAGTTTTCACTGGAACTGATTACAGTAAACAATAATATGTCCCCTTAGTCTTTCTGACA
TTTTTATATAGATTGAGATTGAAAAACCGTGCATTTGGGGCAGTGGTATTATGGTCATTTCGTTGCTATTTTCTGTTTTAATAAAATCCT

>16898_16898_2_CKAP5-TMEM135_CKAP5_chr11_46797805_ENST00000354558_TMEM135_chr11_86778736_ENST00000340353_length(amino acids)=1386AA_BP=997
MGDDSEWLKLPVDQKCEHKLWKARLSGYEEALKIFQKIKDEKSPEWSKFLGLIKKFVTDSNAVVQLKGLEAALVYVENAHVAGKTTGEVV
SGVVSKVFNQPKAKAKELGIEICLMYIEIEKGEAVQEELLKGLDNKNPKIIVACIETLRKALSEFGSKIILLKPIIKVLPKLFESREKAV
RDEAKLIAVEIYRWIRDALRPPLQNINSVQLKELEEEWVKLPTSAPRPTRFLRSQQELEAKLEQQQSAGGDAEGGGDDGDEVPQIDAYEL
LEAVEILSKLPKDFYDKIEAKKWQERKEALESVEVLIKNPKLEAGDYADLVKALKKVVGKDTNVMLVALAAKCLTGLAVGLRKKFGQYAG
HVVPTILEKFKEKKPQVVQALQEAIDAIFLTTTLQNISEDVLAVMDNKNPTIKQQTSLFIARSFRHCTASTLPKSLLKPFCAALLKHIND
SAPEVRDAAFEALGTALKVVGEKAVNPFLADVDKLKLDKIKECSEKVELIHGKKAGLAADKKEFKPLPGRTAASGAAGDKDTKDISAPKP
GPLKKAPAAKAGGPPKKGKPAAPGGAGNTGTKNKKGLETKEIVEPELSIEVCEEKASAVLPPTCIQLLDSSNWKERLACMEEFQKAVELM
DRTEMPCQALVRMLAKKPGWKETNFQVMQMKLHIVALIAQKGNFSKTSAQVVLDGLVDKIGDVKCGNNAKEAMTAIAEACMLPWTAEQVV
SMAFSQKNPKNQSETLNWLSNAIKEFGFSGLNVKAFISNVKTALAATNPAVRTAAITLLGVMYLYVGPSLRMFFEDEKPALLSQIDAEFE
KMQGQSPPAPTRGISKHSTSGTDEGEDGDEPDDGSNDVVDLLPRTEISDKITSELVSKIGDKNWKIRKEGLDEVAGIINDAKFIQPNIGE
LPTALKGRLNDSNKILVQQTLNILQQLAVAMGPNIKQHVKNLGIPIITVLGDSKNNVRAAALATVNAWAEQTGMKEWLEGEDLSEELKKE
NPFLRQEIAAILRKRKLDYYLHKLLPEILQSASFLTANGALYMAFFCILRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLTIYMA
NLVLLFCITAAMYMFFFRCKDGLKGFTFSALRFIVGKEEIPTHSFSPEAAYAKVEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRC
CKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAII
AGFLAGISMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGKFAVMNRK

--------------------------------------------------------------
>16898_16898_3_CKAP5-TMEM135_CKAP5_chr11_46797805_ENST00000415402_TMEM135_chr11_86778736_ENST00000340353_length(transcript)=6696nt_BP=3101nt
ACTGCGGGGTGTGCGGCGGCCCAAGCGGTTTCAAACGGCTTAGAGCAGGCCGCTTGGTTCTGACCCAGCTGAGGAAATACTCTTAATTCT
AAGGAAAACCTGGAAGCACAATGGGAGATGACAGTGAGTGGTTGAAACTGCCAGTTGATCAGAAATGTGAACACAAGCTGTGGAAAGCAA
GGTTAAGTGGGTATGAAGAGGCCCTGAAGATCTTCCAGAAAATAAAGGATGAAAAGAGCCCAGAGTGGTCCAAATTTTTAGGATTGATCA
AAAAATTTGTCACTGATTCCAATGCAGTGGTTCAATTGAAAGGATTAGAAGCTGCACTTGTTTATGTTGAAAATGCCCATGTAGCAGGAA
AAACCACAGGAGAAGTTGTGTCAGGTGTTGTAAGTAAGGTGTTCAATCAACCTAAAGCTAAAGCCAAGGAGCTGGGCATAGAGATCTGTC
TTATGTACATAGAGATTGAGAAAGGAGAGGCTGTTCAAGAAGAGCTCCTGAAAGGCTTGGACAATAAGAATCCCAAGATCATAGTGGCCT
GTATAGAGACACTGAGGAAAGCCTTAAGTGAATTTGGTTCCAAAATCATCTTGCTTAAGCCAATTATCAAAGTGTTGCCAAAACTCTTTG
AGTCTCGAGAGAAGGCTGTTCGAGATGAAGCCAAACTAATTGCTGTGGAGATTTACAGATGGATTCGGGATGCTCTGAGACCCCCATTAC
AAAATATAAACTCTGTTCAGTTGAAAGAACTAGAAGAAGAATGGGTCAAACTGCCAACAAGTGCTCCTAGACCTACTCGATTTCTTCGTT
CCCAACAAGAACTAGAAGCTAAATTGGAACAACAACAGTCTGCTGGTGGAGATGCTGAAGGAGGTGGTGATGATGGTGATGAGGTGCCAC
AAATAGATGCTTATGAGCTTTTAGAAGCTGTAGAAATCCTTTCCAAACTTCCCAAAGACTTTTATGACAAAATTGAGGCAAAAAAATGGC
AAGAGAGAAAAGAGGCCCTGGAGTCTGTAGAAGTACTAATAAAAAACCCCAAACTGGAAGCTGGCGATTATGCAGATTTAGTAAAAGCAT
TAAAGAAGGTTGTTGGAAAGGACACCAATGTCATGTTGGTGGCTTTGGCAGCAAAATGTCTTACTGGCCTGGCTGTTGGGCTAAGGAAGA
AATTTGGACAATATGCAGGACATGTTGTGCCAACCATCTTGGAGAAATTCAAAGAGAAGAAACCTCAAGTGGTACAAGCCCTGCAGGAGG
CAATTGATGCAATCTTCCTTACTACCACACTACAGAACATCAGTGAGGATGTTTTAGCAGTAATGGATAATAAAAATCCAACCATCAAGC
AGCAGACATCTCTTTTTATTGCAAGAAGTTTCCGCCACTGCACTGCTTCTACCCTGCCAAAGAGCTTGCTAAAGCCCTTTTGTGCTGCAC
TACTTAAGCACATCAATGATTCTGCTCCTGAAGTCAGAGATGCCGCATTTGAAGCATTGGGTACTGCTTTGAAGGTGGTTGGCGAGAAAG
CAGTAAACCCATTCCTAGCTGATGTGGACAAACTCAAGCTTGATAAGATCAAAGAATGTTCAGAAAAGGTAGAACTGATACATGGTAAGA
AAGCTGGACTAGCTGCTGATAAGAAGGAATTCAAACCTCTGCCTGGAAGGACTGCTGCTTCAGGGGCTGCAGGAGATAAGGACACAAAGG
ACATTTCTGCACCCAAACCAGGACCTCTAAAAAAGGCACCTGCTGCTAAGGCTGGTGGGCCACCAAAAAAGGGGAAACCAGCTGCACCAG
GAGGCGCAGGGAATACTGGAACCAAGAACAAGAAAGGACTGGAGACTAAAGAAATAGTGGAGCCTGAGCTCTCGATAGAAGTATGTGAAG
AAAAAGCTTCAGCTGTTCTTCCCCCTACCTGTATACAGCTTCTTGACAGCAGTAACTGGAAAGAAAGGCTGGCTTGTATGGAAGAGTTCC
AGAAGGCTGTTGAGCTAATGGACCGAACTGAAATGCCATGCCAGGCATTAGTGAGGATGCTAGCCAAGAAACCTGGATGGAAAGAAACTA
ATTTTCAGGTGATGCAAATGAAGCTTCATATAGTTGCTTTGATTGCCCAGAAGGGAAATTTTTCCAAAACGTCAGCTCAGGTTGTATTAG
ATGGCCTTGTGGACAAGATTGGAGATGTGAAATGTGGGAACAATGCAAAAGAAGCTATGACAGCAATAGCCGAAGCCTGTATGTTACCAT
GGACTGCTGAACAGGTTGTGTCAATGGCTTTCTCACAAAAGAATCCCAAAAATCAGTCAGAAACTCTGAATTGGCTATCAAATGCCATAA
AAGAATTTGGTTTTTCTGGGTTGAATGTCAAAGCTTTCATTAGCAATGTGAAGACAGCTCTTGCTGCAACAAACCCAGCTGTGAGGACTG
CTGCCATAACCCTGCTTGGCGTGATGTATCTGTATGTTGGTCCCTCTTTGCGAATGTTCTTTGAGGATGAGAAGCCTGCCCTCCTATCCC
AGATAGATGCAGAATTTGAGAAGATGCAGGGACAAAGTCCACCTGCTCCAACCAGAGGAATTTCCAAGCATAGCACAAGTGGTACAGATG
AAGGAGAAGATGGAGATGAACCAGATGACGGGAGCAATGATGTCGTTGATCTTTTGCCGAGGACGGAGATCAGTGATAAAATCACTTCAG
AGTTGGTATCTAAGATTGGTGATAAGAATTGGAAGATTAGGAAAGAAGGCCTAGATGAAGTGGCAGGTATTATTAATGACGCAAAATTTA
TCCAACCGAATATAGGTGAACTTCCAACTGCCTTGAAGGGTCGACTCAATGATTCAAATAAAATCTTGGTACAGCAAACGCTGAATATCC
TGCAACAACTGGCAGTAGCCATGGGCCCAAATATTAAGCAACATGTAAAAAATTTAGGCATCCCTATCATCACAGTCCTTGGAGACAGCA
AGAACAATGTTCGAGCTGCTGCCCTAGCGACTGTGAATGCTTGGGCAGAACAGACTGGCATGAAGGAATGGCTGGAAGGAGAAGATCTTT
CTGAAGAGCTCAAAAAGGAAAATCCTTTCTTGAGGCAAGAGATTGCAGCAATTCTCCGGAAACGGAAATTAGACTATTATTTACACAAAC
TACTCCCTGAGATCCTACAATCCGCTTCATTTCTAACTGCTAATGGGGCCTTGTATATGGCTTTCTTTTGCATTTTAAGGAAGATACTTG
GAAAATTCTACTCATGGACTCCTGGCTTTGGTGCCGCTCTGCCAGCATCTTATGTGGCCATTCTCATTGAAAGAAAAAGCAGGAGAGGGC
TGCTCACAATTTATATGGCCAACTTGGTCCTTTTGTTTTGCATCACAGCTGCCATGTACATGTTCTTTTTCAGGTGCAAGGATGGCTTGA
AAGGATTTACATTTTCTGCACTTAGGTTCATTGTAGGGAAGGAAGAAATTCCCACACATTCTTTTTCACCAGAGGCAGCATATGCAAAAG
TGGAACAAAAGAGAGAGCAACATGAGGAAAAACCCGGAAGAATGAATATGATTGGTCTAGTCAGGAAATTTGTGGATTCAATATGCAAAC
ATGGACCAAGGCATAGATGTTGCAAACATTATGAAGATAATTGCATCTCTTATTGCATTAAAGGTTTCATCAGAATGTTTAGCGTGGGGT
ACTTGATCCAGTGCTGCCTCCGAATCCCTTCTGCATTTAGGCATCTGTTTACACAGCCATCTCGGCTACTTTCTCTCTTCTACAATAAAG
AAAACTTCCAGCTTGGAGCTTTTCTTGGCTCTTTTGTTAGTATATACAAGGGTACTAGTTGCTTCCTGCGCTGGATCAGAAACTTAGATG
ATGAACTACATGCTATTATAGCTGGATTTTTGGCAGGTATATCAATGATGTTTTATAAAAGCACAACAATTTCCATGTATTTAGCGTCCA
AATTGGTAGAGACAATGTATTTCAAAGGCATTGAAGCAGGGAAGGTTCCCTATTTTCCTCATGCAGATACTATCATCTATTCCATCTCTA
CAGCAATTTGCTTCCAGGCAGCTGTCATGGAAGTTCAGACTTTGAGACCATCTTACTGGAAGTTCCTTTTAAGACTCACCAAGGGCAAAT
TTGCTGTCATGAACCGAAAAGTCCTTGATGTTTTTGGTACTGGTGCATCTAAACACTTTCAGGATTTCATCCCCAGGTTGGATCCAAGAT
ACACAACTGTAACACCAGAGTTGCCCACAGAGTTTTCCTGAAGATGACTGTAACTTATTAATGTGACTAAATGTTTCATCTTGAAGAGTT
AATTATGTTGAACACAAAGGAGGGGGCCCAAGCTCGAACTTCAGTGTTATTTCAGTTAGAGATACTCTTTTCATTTGTTTTGTTTTTCTT
ATGAATCAGAAATTCAGAAGCTTTTTAGGAAGATGTTGCTTAATAATTAAGCTTCCTCCATAGCCAGAATAAGATTCTGGATCACTGTAG
TGACTGACATTATATATTATTGATCAAATTATGTCCACAAGCAATATTATATAATCTACGTAGAAGTGTAATAACAAACAAGAGTACACT
TAAAATTACTTTAAAAGATGTCTTTAGTTCATTCCAATATAATTCTTGATTAAAATTAGGATTATTTCTACATTTTAGGATTTACAAAGG
ATCACGGGTACATGGATTTGGTCTATATATTTTTTTAAAGTTTTGAATTGGTATCTGTAGTAGTGGAATGTTATAGATTTGAAGTAACTC
TCCACGGACAGTGCTGCTTTCGTGTAGAGCAATTTAATTGGAGAAGTGGCCATTCTTACTTCAGGGATGCAAAGATGGGTCTCATACCAT
TTGGATAAATGTCGTGGTATCCATGCTTTTTTTCAACTAATAACATCATCTCTCTTCATGACCAGTTAATTGGGCTATTTGGCAGCCCAG
TGAACCTATGTACTAATGGCAAGTTAGGGGCAAATGGAAATGGACACATCCGATAAAGTTGAAATGTATGTTTTAATCTTTCACAGAAGT
ATTACACTTGAATATTTAAAAACAAAACTTTTAAACTTCCTATAGGTTTATGATGTTTGTTTTCATTTATATGGACATAATCCTTCATAG
CTCAGTTTATATGCCATTGTTGTATTAGAAGGGATCAAAATCCTATGGAACAAAGTAGTCTTGGCAAGTTGGCAGTTTGTGTCCTCTCAG
CTGTTTAACTTATGTAATGGATGTTTTGCACCTGAAAACACTATAAAAATCCAGTGGTTGTTTAAAAAGTCCATTTGTCACTAATTCCAT
TCAGGTTCTCCAACCTTCTTCTTGAATATCATTGTCACCATTTTTACTGTTAGAATAAAGAGGTGACACCATAAAGTCCTGCTGATAATG
AGAGTAGTTCAGGACAGCTGTGATTGAAATATGGTCGCTATTTACAGTTTTTCAGGGAAAAGTTATACTTTTCTATGTTAATAAAGAGCT
GAAGTGGTCTACAGTTAATGTGACATGTAGGGATGATGATATTTTTAAAATACATTTTGTTGCTAAAAAGTTTTTAGGCCAGTGCAAATT
ATGCAGTAGAACTTGTGTTGCAAAAGGAATTATAACCCATACTTTAAAAATGCTTAATCCCTCATATTCAATTTCATCAAGCCTTGTATA
CTTCTGCTTAAATGTAATTCAATCCTTGGTTGTTATGGCAAACAGAAACCCAACAAAAAGACAGACTCTGGTACTATGGTAACAGAGCCA
CTTTATCATTTGGTCAAAATTTGGCATTATGATTAGCTTTGTAGAACTGACCTGTTTATTTGGCAATGCTGTTAAAGGATCATTTCGGTT
TCAGACTTCAAAGTTGATTAATAAATTTAATCTTAACTTTTTATTCACTGGAATCAAAACGATGGTTGGTACTGTGTTTACTGTTTAAAA
TGAAGTACTAAAGCCCTGAGAACTGCACCTCATTTTCTTTATCCAGAAATTGTGCTTATATATTTTCCTGTCAGGTTTAAAAAGATGTTT
TAATTCATAAATTATTGTTTTCATTGACATTAAAAGACTGTGATATTGAAAGATGAATTACGAAATTTGCTGAGATTGTTTAGTAAAATT
TTGCTGGTCAAAAAGGTGTATTTCTACAATTTACCTTTTCATTTTTATAAATTGCAGTCATTTTTTTAAATTTTATGTAAAATGTAAAAT
GAAATAGCTATCATGAAGCAGAATACAATGATGAATGTATAGGTTGAGTGAATAACCAATTTGCAGTGGTGGATTGAGAAGTCCAGTTTG
ATTTCATTGGGACAGACTGCAAAGTGTAGTTGTTTGAGCAAACACAAAGAAACTTTGTGTTTTTGAAGACAATCAGAATGATTACCTTTC
TACCTCTAACTAATCAGGTATTGATTGACAACTTTTTGGCATTATAAATAAAGTAAAATAGATCTCTGCATTCCAAAATATGTTTTTTAG
TTTATTTATATCCTGAAGAAATGGTAAGTTTTCACTGGAACTGATTACAGTAAACAATAATATGTCCCCTTAGTCTTTCTGACATTTTTA
TATAGATTGAGATTGAAAAACCGTGCATTTGGGGCAGTGGTATTATGGTCATTTCGTTGCTATTTTCTGTTTTAATAAAATCCTAGAACT

>16898_16898_3_CKAP5-TMEM135_CKAP5_chr11_46797805_ENST00000415402_TMEM135_chr11_86778736_ENST00000340353_length(amino acids)=1386AA_BP=997
MGDDSEWLKLPVDQKCEHKLWKARLSGYEEALKIFQKIKDEKSPEWSKFLGLIKKFVTDSNAVVQLKGLEAALVYVENAHVAGKTTGEVV
SGVVSKVFNQPKAKAKELGIEICLMYIEIEKGEAVQEELLKGLDNKNPKIIVACIETLRKALSEFGSKIILLKPIIKVLPKLFESREKAV
RDEAKLIAVEIYRWIRDALRPPLQNINSVQLKELEEEWVKLPTSAPRPTRFLRSQQELEAKLEQQQSAGGDAEGGGDDGDEVPQIDAYEL
LEAVEILSKLPKDFYDKIEAKKWQERKEALESVEVLIKNPKLEAGDYADLVKALKKVVGKDTNVMLVALAAKCLTGLAVGLRKKFGQYAG
HVVPTILEKFKEKKPQVVQALQEAIDAIFLTTTLQNISEDVLAVMDNKNPTIKQQTSLFIARSFRHCTASTLPKSLLKPFCAALLKHIND
SAPEVRDAAFEALGTALKVVGEKAVNPFLADVDKLKLDKIKECSEKVELIHGKKAGLAADKKEFKPLPGRTAASGAAGDKDTKDISAPKP
GPLKKAPAAKAGGPPKKGKPAAPGGAGNTGTKNKKGLETKEIVEPELSIEVCEEKASAVLPPTCIQLLDSSNWKERLACMEEFQKAVELM
DRTEMPCQALVRMLAKKPGWKETNFQVMQMKLHIVALIAQKGNFSKTSAQVVLDGLVDKIGDVKCGNNAKEAMTAIAEACMLPWTAEQVV
SMAFSQKNPKNQSETLNWLSNAIKEFGFSGLNVKAFISNVKTALAATNPAVRTAAITLLGVMYLYVGPSLRMFFEDEKPALLSQIDAEFE
KMQGQSPPAPTRGISKHSTSGTDEGEDGDEPDDGSNDVVDLLPRTEISDKITSELVSKIGDKNWKIRKEGLDEVAGIINDAKFIQPNIGE
LPTALKGRLNDSNKILVQQTLNILQQLAVAMGPNIKQHVKNLGIPIITVLGDSKNNVRAAALATVNAWAEQTGMKEWLEGEDLSEELKKE
NPFLRQEIAAILRKRKLDYYLHKLLPEILQSASFLTANGALYMAFFCILRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLTIYMA
NLVLLFCITAAMYMFFFRCKDGLKGFTFSALRFIVGKEEIPTHSFSPEAAYAKVEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRC
CKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAII
AGFLAGISMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGKFAVMNRK

--------------------------------------------------------------
>16898_16898_4_CKAP5-TMEM135_CKAP5_chr11_46797805_ENST00000529230_TMEM135_chr11_86778736_ENST00000340353_length(transcript)=6633nt_BP=3038nt
CCCAGCTGAGGAAATACTCTTAATTCTAAGGAAAACCTGGAAGCACAATGGGAGATGACAGTGAGTGGTTGAAACTGCCAGTTGATCAGA
AATGTGAACACAAGCTGTGGAAAGCAAGGTTAAGTGGGTATGAAGAGGCCCTGAAGATCTTCCAGAAAATAAAGGATGAAAAGAGCCCAG
AGTGGTCCAAATTTTTAGGATTGATCAAAAAATTTGTCACTGATTCCAATGCAGTGGTTCAATTGAAAGGATTAGAAGCTGCACTTGTTT
ATGTTGAAAATGCCCATGTAGCAGGAAAAACCACAGGAGAAGTTGTGTCAGGTGTTGTAAGTAAGGTGTTCAATCAACCTAAAGCTAAAG
CCAAGGAGCTGGGCATAGAGATCTGTCTTATGTACATAGAGATTGAGAAAGGAGAGGCTGTTCAAGAAGAGCTCCTGAAAGGCTTGGACA
ATAAGAATCCCAAGATCATAGTGGCCTGTATAGAGACACTGAGGAAAGCCTTAAGTGAATTTGGTTCCAAAATCATCTTGCTTAAGCCAA
TTATCAAAGTGTTGCCAAAACTCTTTGAGTCTCGAGAGAAGGCTGTTCGAGATGAAGCCAAACTAATTGCTGTGGAGATTTACAGATGGA
TTCGGGATGCTCTGAGACCCCCATTACAAAATATAAACTCTGTTCAGTTGAAAGAACTAGAAGAAGAATGGGTCAAACTGCCAACAAGTG
CTCCTAGACCTACTCGATTTCTTCGTTCCCAACAAGAACTAGAAGCTAAATTGGAACAACAACAGTCTGCTGGTGGAGATGCTGAAGGAG
GTGGTGATGATGGTGATGAGGTGCCACAAATAGATGCTTATGAGCTTTTAGAAGCTGTAGAAATCCTTTCCAAACTTCCCAAAGACTTTT
ATGACAAAATTGAGGCAAAAAAATGGCAAGAGAGAAAAGAGGCCCTGGAGTCTGTAGAAGTACTAATAAAAAACCCCAAACTGGAAGCTG
GCGATTATGCAGATTTAGTAAAAGCATTAAAGAAGGTTGTTGGAAAGGACACCAATGTCATGTTGGTGGCTTTGGCAGCAAAATGTCTTA
CTGGCCTGGCTGTTGGGCTAAGGAAGAAATTTGGACAATATGCAGGACATGTTGTGCCAACCATCTTGGAGAAATTCAAAGAGAAGAAAC
CTCAAGTGGTACAAGCCCTGCAGGAGGCAATTGATGCAATCTTCCTTACTACCACACTACAGAACATCAGTGAGGATGTTTTAGCAGTAA
TGGATAATAAAAATCCAACCATCAAGCAGCAGACATCTCTTTTTATTGCAAGAAGTTTCCGCCACTGCACTGCTTCTACCCTGCCAAAGA
GCTTGCTAAAGCCCTTTTGTGCTGCACTACTTAAGCACATCAATGATTCTGCTCCTGAAGTCAGAGATGCCGCATTTGAAGCATTGGGTA
CTGCTTTGAAGGTGGTTGGCGAGAAAGCAGTAAACCCATTCCTAGCTGATGTGGACAAACTCAAGCTTGATAAGATCAAAGAATGTTCAG
AAAAGGTAGAACTGATACATGGTAAGAAAGCTGGACTAGCTGCTGATAAGAAGGAATTCAAACCTCTGCCTGGAAGGACTGCTGCTTCAG
GGGCTGCAGGAGATAAGGACACAAAGGACATTTCTGCACCCAAACCAGGACCTCTAAAAAAGGCACCTGCTGCTAAGGCTGGTGGGCCAC
CAAAAAAGGGGAAACCAGCTGCACCAGGAGGCGCAGGGAATACTGGAACCAAGAACAAGAAAGGACTGGAGACTAAAGAAATAGTGGAGC
CTGAGCTCTCGATAGAAGTATGTGAAGAAAAAGCTTCAGCTGTTCTTCCCCCTACCTGTATACAGCTTCTTGACAGCAGTAACTGGAAAG
AAAGGCTGGCTTGTATGGAAGAGTTCCAGAAGGCTGTTGAGCTAATGGACCGAACTGAAATGCCATGCCAGGCATTAGTGAGGATGCTAG
CCAAGAAACCTGGATGGAAAGAAACTAATTTTCAGGTGATGCAAATGAAGCTTCATATAGTTGCTTTGATTGCCCAGAAGGGAAATTTTT
CCAAAACGTCAGCTCAGGTTGTATTAGATGGCCTTGTGGACAAGATTGGAGATGTGAAATGTGGGAACAATGCAAAAGAAGCTATGACAG
CAATAGCCGAAGCCTGTATGTTACCATGGACTGCTGAACAGGTTGTGTCAATGGCTTTCTCACAAAAGAATCCCAAAAATCAGTCAGAAA
CTCTGAATTGGCTATCAAATGCCATAAAAGAATTTGGTTTTTCTGGGTTGAATGTCAAAGCTTTCATTAGCAATGTGAAGACAGCTCTTG
CTGCAACAAACCCAGCTGTGAGGACTGCTGCCATAACCCTGCTTGGCGTGATGTATCTGTATGTTGGTCCCTCTTTGCGAATGTTCTTTG
AGGATGAGAAGCCTGCCCTCCTATCCCAGATAGATGCAGAATTTGAGAAGATGCAGGGACAAAGTCCACCTGCTCCAACCAGAGGAATTT
CCAAGCATAGCACAAGTGGTACAGATGAAGGAGAAGATGGAGATGAACCAGATGACGGGAGCAATGATGTCGTTGATCTTTTGCCGAGGA
CGGAGATCAGTGATAAAATCACTTCAGAGTTGGTATCTAAGATTGGTGATAAGAATTGGAAGATTAGGAAAGAAGGCCTAGATGAAGTGG
CAGGTATTATTAATGACGCAAAATTTATCCAACCGAATATAGGTGAACTTCCAACTGCCTTGAAGGGTCGACTCAATGATTCAAATAAAA
TCTTGGTACAGCAAACGCTGAATATCCTGCAACAACTGGCAGTAGCCATGGGCCCAAATATTAAGCAACATGTAAAAAATTTAGGCATCC
CTATCATCACAGTCCTTGGAGACAGCAAGAACAATGTTCGAGCTGCTGCCCTAGCGACTGTGAATGCTTGGGCAGAACAGACTGGCATGA
AGGAATGGCTGGAAGGAGAAGATCTTTCTGAAGAGCTCAAAAAGGAAAATCCTTTCTTGAGGCAAGAGATTGCAGCAATTCTCCGGAAAC
GGAAATTAGACTATTATTTACACAAACTACTCCCTGAGATCCTACAATCCGCTTCATTTCTAACTGCTAATGGGGCCTTGTATATGGCTT
TCTTTTGCATTTTAAGGAAGATACTTGGAAAATTCTACTCATGGACTCCTGGCTTTGGTGCCGCTCTGCCAGCATCTTATGTGGCCATTC
TCATTGAAAGAAAAAGCAGGAGAGGGCTGCTCACAATTTATATGGCCAACTTGGTCCTTTTGTTTTGCATCACAGCTGCCATGTACATGT
TCTTTTTCAGGTGCAAGGATGGCTTGAAAGGATTTACATTTTCTGCACTTAGGTTCATTGTAGGGAAGGAAGAAATTCCCACACATTCTT
TTTCACCAGAGGCAGCATATGCAAAAGTGGAACAAAAGAGAGAGCAACATGAGGAAAAACCCGGAAGAATGAATATGATTGGTCTAGTCA
GGAAATTTGTGGATTCAATATGCAAACATGGACCAAGGCATAGATGTTGCAAACATTATGAAGATAATTGCATCTCTTATTGCATTAAAG
GTTTCATCAGAATGTTTAGCGTGGGGTACTTGATCCAGTGCTGCCTCCGAATCCCTTCTGCATTTAGGCATCTGTTTACACAGCCATCTC
GGCTACTTTCTCTCTTCTACAATAAAGAAAACTTCCAGCTTGGAGCTTTTCTTGGCTCTTTTGTTAGTATATACAAGGGTACTAGTTGCT
TCCTGCGCTGGATCAGAAACTTAGATGATGAACTACATGCTATTATAGCTGGATTTTTGGCAGGTATATCAATGATGTTTTATAAAAGCA
CAACAATTTCCATGTATTTAGCGTCCAAATTGGTAGAGACAATGTATTTCAAAGGCATTGAAGCAGGGAAGGTTCCCTATTTTCCTCATG
CAGATACTATCATCTATTCCATCTCTACAGCAATTTGCTTCCAGGCAGCTGTCATGGAAGTTCAGACTTTGAGACCATCTTACTGGAAGT
TCCTTTTAAGACTCACCAAGGGCAAATTTGCTGTCATGAACCGAAAAGTCCTTGATGTTTTTGGTACTGGTGCATCTAAACACTTTCAGG
ATTTCATCCCCAGGTTGGATCCAAGATACACAACTGTAACACCAGAGTTGCCCACAGAGTTTTCCTGAAGATGACTGTAACTTATTAATG
TGACTAAATGTTTCATCTTGAAGAGTTAATTATGTTGAACACAAAGGAGGGGGCCCAAGCTCGAACTTCAGTGTTATTTCAGTTAGAGAT
ACTCTTTTCATTTGTTTTGTTTTTCTTATGAATCAGAAATTCAGAAGCTTTTTAGGAAGATGTTGCTTAATAATTAAGCTTCCTCCATAG
CCAGAATAAGATTCTGGATCACTGTAGTGACTGACATTATATATTATTGATCAAATTATGTCCACAAGCAATATTATATAATCTACGTAG
AAGTGTAATAACAAACAAGAGTACACTTAAAATTACTTTAAAAGATGTCTTTAGTTCATTCCAATATAATTCTTGATTAAAATTAGGATT
ATTTCTACATTTTAGGATTTACAAAGGATCACGGGTACATGGATTTGGTCTATATATTTTTTTAAAGTTTTGAATTGGTATCTGTAGTAG
TGGAATGTTATAGATTTGAAGTAACTCTCCACGGACAGTGCTGCTTTCGTGTAGAGCAATTTAATTGGAGAAGTGGCCATTCTTACTTCA
GGGATGCAAAGATGGGTCTCATACCATTTGGATAAATGTCGTGGTATCCATGCTTTTTTTCAACTAATAACATCATCTCTCTTCATGACC
AGTTAATTGGGCTATTTGGCAGCCCAGTGAACCTATGTACTAATGGCAAGTTAGGGGCAAATGGAAATGGACACATCCGATAAAGTTGAA
ATGTATGTTTTAATCTTTCACAGAAGTATTACACTTGAATATTTAAAAACAAAACTTTTAAACTTCCTATAGGTTTATGATGTTTGTTTT
CATTTATATGGACATAATCCTTCATAGCTCAGTTTATATGCCATTGTTGTATTAGAAGGGATCAAAATCCTATGGAACAAAGTAGTCTTG
GCAAGTTGGCAGTTTGTGTCCTCTCAGCTGTTTAACTTATGTAATGGATGTTTTGCACCTGAAAACACTATAAAAATCCAGTGGTTGTTT
AAAAAGTCCATTTGTCACTAATTCCATTCAGGTTCTCCAACCTTCTTCTTGAATATCATTGTCACCATTTTTACTGTTAGAATAAAGAGG
TGACACCATAAAGTCCTGCTGATAATGAGAGTAGTTCAGGACAGCTGTGATTGAAATATGGTCGCTATTTACAGTTTTTCAGGGAAAAGT
TATACTTTTCTATGTTAATAAAGAGCTGAAGTGGTCTACAGTTAATGTGACATGTAGGGATGATGATATTTTTAAAATACATTTTGTTGC
TAAAAAGTTTTTAGGCCAGTGCAAATTATGCAGTAGAACTTGTGTTGCAAAAGGAATTATAACCCATACTTTAAAAATGCTTAATCCCTC
ATATTCAATTTCATCAAGCCTTGTATACTTCTGCTTAAATGTAATTCAATCCTTGGTTGTTATGGCAAACAGAAACCCAACAAAAAGACA
GACTCTGGTACTATGGTAACAGAGCCACTTTATCATTTGGTCAAAATTTGGCATTATGATTAGCTTTGTAGAACTGACCTGTTTATTTGG
CAATGCTGTTAAAGGATCATTTCGGTTTCAGACTTCAAAGTTGATTAATAAATTTAATCTTAACTTTTTATTCACTGGAATCAAAACGAT
GGTTGGTACTGTGTTTACTGTTTAAAATGAAGTACTAAAGCCCTGAGAACTGCACCTCATTTTCTTTATCCAGAAATTGTGCTTATATAT
TTTCCTGTCAGGTTTAAAAAGATGTTTTAATTCATAAATTATTGTTTTCATTGACATTAAAAGACTGTGATATTGAAAGATGAATTACGA
AATTTGCTGAGATTGTTTAGTAAAATTTTGCTGGTCAAAAAGGTGTATTTCTACAATTTACCTTTTCATTTTTATAAATTGCAGTCATTT
TTTTAAATTTTATGTAAAATGTAAAATGAAATAGCTATCATGAAGCAGAATACAATGATGAATGTATAGGTTGAGTGAATAACCAATTTG
CAGTGGTGGATTGAGAAGTCCAGTTTGATTTCATTGGGACAGACTGCAAAGTGTAGTTGTTTGAGCAAACACAAAGAAACTTTGTGTTTT
TGAAGACAATCAGAATGATTACCTTTCTACCTCTAACTAATCAGGTATTGATTGACAACTTTTTGGCATTATAAATAAAGTAAAATAGAT
CTCTGCATTCCAAAATATGTTTTTTAGTTTATTTATATCCTGAAGAAATGGTAAGTTTTCACTGGAACTGATTACAGTAAACAATAATAT
GTCCCCTTAGTCTTTCTGACATTTTTATATAGATTGAGATTGAAAAACCGTGCATTTGGGGCAGTGGTATTATGGTCATTTCGTTGCTAT

>16898_16898_4_CKAP5-TMEM135_CKAP5_chr11_46797805_ENST00000529230_TMEM135_chr11_86778736_ENST00000340353_length(amino acids)=1386AA_BP=997
MGDDSEWLKLPVDQKCEHKLWKARLSGYEEALKIFQKIKDEKSPEWSKFLGLIKKFVTDSNAVVQLKGLEAALVYVENAHVAGKTTGEVV
SGVVSKVFNQPKAKAKELGIEICLMYIEIEKGEAVQEELLKGLDNKNPKIIVACIETLRKALSEFGSKIILLKPIIKVLPKLFESREKAV
RDEAKLIAVEIYRWIRDALRPPLQNINSVQLKELEEEWVKLPTSAPRPTRFLRSQQELEAKLEQQQSAGGDAEGGGDDGDEVPQIDAYEL
LEAVEILSKLPKDFYDKIEAKKWQERKEALESVEVLIKNPKLEAGDYADLVKALKKVVGKDTNVMLVALAAKCLTGLAVGLRKKFGQYAG
HVVPTILEKFKEKKPQVVQALQEAIDAIFLTTTLQNISEDVLAVMDNKNPTIKQQTSLFIARSFRHCTASTLPKSLLKPFCAALLKHIND
SAPEVRDAAFEALGTALKVVGEKAVNPFLADVDKLKLDKIKECSEKVELIHGKKAGLAADKKEFKPLPGRTAASGAAGDKDTKDISAPKP
GPLKKAPAAKAGGPPKKGKPAAPGGAGNTGTKNKKGLETKEIVEPELSIEVCEEKASAVLPPTCIQLLDSSNWKERLACMEEFQKAVELM
DRTEMPCQALVRMLAKKPGWKETNFQVMQMKLHIVALIAQKGNFSKTSAQVVLDGLVDKIGDVKCGNNAKEAMTAIAEACMLPWTAEQVV
SMAFSQKNPKNQSETLNWLSNAIKEFGFSGLNVKAFISNVKTALAATNPAVRTAAITLLGVMYLYVGPSLRMFFEDEKPALLSQIDAEFE
KMQGQSPPAPTRGISKHSTSGTDEGEDGDEPDDGSNDVVDLLPRTEISDKITSELVSKIGDKNWKIRKEGLDEVAGIINDAKFIQPNIGE
LPTALKGRLNDSNKILVQQTLNILQQLAVAMGPNIKQHVKNLGIPIITVLGDSKNNVRAAALATVNAWAEQTGMKEWLEGEDLSEELKKE
NPFLRQEIAAILRKRKLDYYLHKLLPEILQSASFLTANGALYMAFFCILRKILGKFYSWTPGFGAALPASYVAILIERKSRRGLLTIYMA
NLVLLFCITAAMYMFFFRCKDGLKGFTFSALRFIVGKEEIPTHSFSPEAAYAKVEQKREQHEEKPGRMNMIGLVRKFVDSICKHGPRHRC
CKHYEDNCISYCIKGFIRMFSVGYLIQCCLRIPSAFRHLFTQPSRLLSLFYNKENFQLGAFLGSFVSIYKGTSCFLRWIRNLDDELHAII
AGFLAGISMMFYKSTTISMYLASKLVETMYFKGIEAGKVPYFPHADTIIYSISTAICFQAAVMEVQTLRPSYWKFLLRLTKGKFAVMNRK

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CKAP5-TMEM135


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneCKAP5chr11:46797805chr11:86778736ENST00000312055-24431932_1957997.01973.0TACC3
HgeneCKAP5chr11:46797805chr11:86778736ENST00000354558-23421932_1957997.01973.0TACC3
HgeneCKAP5chr11:46797805chr11:86778736ENST00000415402-24441932_1957997.02040.0TACC3
HgeneCKAP5chr11:46797805chr11:86778736ENST00000529230-24441932_1957997.02033.0TACC3


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CKAP5-TMEM135


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CKAP5-TMEM135


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCKAP5C0002938Aneuploidy1CTD_human
HgeneCKAP5C1257806Chromosomal Instability1CTD_human
TgeneC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneC0017636Glioblastoma1CTD_human
TgeneC0020796Profound Mental Retardation1CTD_human
TgeneC0025363Mental Retardation, Psychosocial1CTD_human
TgeneC0334588Giant Cell Glioblastoma1CTD_human
TgeneC0917816Mental deficiency1CTD_human
TgeneC1621958Glioblastoma Multiforme1CTD_human
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