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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGEF17-EP300 (FusionGDB2 ID:HG9828TG2033)

Fusion Gene Summary for ARHGEF17-EP300

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGEF17-EP300
Fusion gene ID: hg9828tg2033
HgeneTgene
Gene symbol

ARHGEF17

EP300

Gene ID

9828

2033

Gene nameRho guanine nucleotide exchange factor 17E1A binding protein p300
SynonymsP164RHOGEF|RHOGEF17|TEM4|p164-RhoGEFKAT3B|MKHK2|RSTS2|p300
Cytomap('ARHGEF17')('EP300')

11q13.4

22q13.2

Type of geneprotein-codingprotein-coding
Descriptionrho guanine nucleotide exchange factor 17164 kDa Rho-specific guanine-nucleotide exchange factorRho guanine nucleotide exchange factor (GEF) 17Rho-specific guanine-nucleotide exchange factor 164 kDatumor endothelial marker 4histone acetyltransferase p300E1A-associated protein p300E1A-binding protein, 300kDhistone butyryltransferase p300histone crotonyltransferase p300p300 HATprotein 2-hydroxyisobutyryltransferase p300protein propionyltransferase p300
Modification date2020031320200329
UniProtAcc.

Q09472

Ensembl transtripts involved in fusion geneENST00000263674, ENST00000536170, 
Fusion gene scores* DoF score9 X 3 X 5=13522 X 26 X 8=4576
# samples 1025
** MAII scorelog2(10/135*10)=-0.432959407276106
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/4576*10)=-4.1940870521163
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGEF17 [Title/Abstract] AND EP300 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGEF17(73022875)-EP300(41545042), # samples:3
Anticipated loss of major functional domain due to fusion event.ARHGEF17-EP300 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF17-EP300 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF17-EP300 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGEF17-EP300 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneARHGEF17

GO:0030036

actin cytoskeleton organization

12071859

TgeneEP300

GO:0000122

negative regulation of transcription by RNA polymerase II

10733570

TgeneEP300

GO:0001666

response to hypoxia

9887100|15261140

TgeneEP300

GO:0006110

regulation of glycolytic process

29775581

TgeneEP300

GO:0006355

regulation of transcription, DNA-templated

15261140

TgeneEP300

GO:0006473

protein acetylation

21030595|24939902

TgeneEP300

GO:0006475

internal protein amino acid acetylation

18722353

TgeneEP300

GO:0010742

macrophage derived foam cell differentiation

26504087

TgeneEP300

GO:0010976

positive regulation of neuron projection development

27256286

TgeneEP300

GO:0016573

histone acetylation

25818647|27256286

TgeneEP300

GO:0018076

N-terminal peptidyl-lysine acetylation

12435739

TgeneEP300

GO:0018393

internal peptidyl-lysine acetylation

17403783

TgeneEP300

GO:0018394

peptidyl-lysine acetylation

23811396|23962722

TgeneEP300

GO:0031333

negative regulation of protein complex assembly

23962722

TgeneEP300

GO:0034644

cellular response to UV

24939902

TgeneEP300

GO:0042771

intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator

17403783

TgeneEP300

GO:0043627

response to estrogen

11581164

TgeneEP300

GO:0043923

positive regulation by host of viral transcription

16687403

TgeneEP300

GO:0043969

histone H2B acetylation

23415232

TgeneEP300

GO:0045721

negative regulation of gluconeogenesis

30193097

TgeneEP300

GO:0045815

positive regulation of gene expression, epigenetic

25818647

TgeneEP300

GO:0045944

positive regulation of transcription by RNA polymerase II

12586840|18722353|23811396

TgeneEP300

GO:0051091

positive regulation of DNA-binding transcription factor activity

10518217|25818647

TgeneEP300

GO:0060765

regulation of androgen receptor signaling pathway

18487222

TgeneEP300

GO:0061921

peptidyl-lysine propionylation

17267393

TgeneEP300

GO:0090043

regulation of tubulin deacetylation

18722353

TgeneEP300

GO:0140066

peptidyl-lysine crotonylation

25818647

TgeneEP300

GO:0140067

peptidyl-lysine butyrylation

17267393|29775581

TgeneEP300

GO:1901224

positive regulation of NIK/NF-kappaB signaling

23811396

TgeneEP300

GO:1905636

positive regulation of RNA polymerase II regulatory region sequence-specific DNA binding

23811396


check buttonFusion gene breakpoints across ARHGEF17 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across EP300 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-BH-A0AU-01AARHGEF17chr11

73022875

-EP300chr22

41545042

+
ChimerDB4BRCATCGA-BH-A0AU-01AARHGEF17chr11

73022875

+EP300chr22

41545042

+
ChimerDB4BRCATCGA-BH-A0AUARHGEF17chr11

73022875

+EP300chr22

41545041

+


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Fusion Gene ORF analysis for ARHGEF17-EP300

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
In-frameENST00000263674ENST00000263253ARHGEF17chr11

73022875

+EP300chr22

41545042

+
In-frameENST00000263674ENST00000263253ARHGEF17chr11

73022875

+EP300chr22

41545041

+
intron-3CDSENST00000536170ENST00000263253ARHGEF17chr11

73022875

+EP300chr22

41545042

+
intron-3CDSENST00000536170ENST00000263253ARHGEF17chr11

73022875

+EP300chr22

41545041

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000263674ARHGEF17chr1173022875+ENST00000263253EP300chr2241545042+9667354220985452778
ENST00000263674ARHGEF17chr1173022875+ENST00000263253EP300chr2241545041+9667354220985452778

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000263674ENST00000263253ARHGEF17chr1173022875+EP300chr2241545042+0.002764920.9972351
ENST00000263674ENST00000263253ARHGEF17chr1173022875+EP300chr2241545041+0.002764920.9972351

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Fusion Genomic Features for ARHGEF17-EP300


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
ARHGEF17chr1173022875+EP300chr2241545041+3.12E-050.99996877
ARHGEF17chr1173022875+EP300chr2241545041+3.12E-050.99996877
ARHGEF17chr1173022875+EP300chr2241545041+3.12E-050.99996877
ARHGEF17chr1173022875+EP300chr2241545041+3.12E-050.99996877

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for ARHGEF17-EP300


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:73022875/chr22:41545042)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.EP300

Q09472

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Functions as histone acetyltransferase and regulates transcription via chromatin remodeling (PubMed:23415232, PubMed:23934153, PubMed:8945521). Acetylates all four core histones in nucleosomes. Histone acetylation gives an epigenetic tag for transcriptional activation (PubMed:23415232, PubMed:23934153, PubMed:8945521). Mediates cAMP-gene regulation by binding specifically to phosphorylated CREB protein. Mediates acetylation of histone H3 at 'Lys-122' (H3K122ac), a modification that localizes at the surface of the histone octamer and stimulates transcription, possibly by promoting nucleosome instability. Mediates acetylation of histone H3 at 'Lys-27' (H3K27ac) (PubMed:23911289). Also functions as acetyltransferase for non-histone targets, such as ALX1, HDAC1, PRMT1 or SIRT2 (PubMed:12929931, PubMed:16762839, PubMed:18722353). Acetylates 'Lys-131' of ALX1 and acts as its coactivator (PubMed:12929931). Acetylates SIRT2 and is proposed to indirectly increase the transcriptional activity of p53/TP53 through acetylation and subsequent attenuation of SIRT2 deacetylase function (PubMed:18722353). Following DNA damage, forms a stress-responsive p53/TP53 coactivator complex with JMY which mediates p53/TP53 acetylation, thereby increasing p53/TP53-dependent transcription and apoptosis (PubMed:11511361, PubMed:15448695). Promotes chromatin acetylation in heat shock responsive HSP genes during the heat shock response (HSR), thereby stimulating HSR transcription (PubMed:18451878). Acetylates HDAC1 leading to its inactivation and modulation of transcription (PubMed:16762839). Acetylates 'Lys-247' of EGR2 (By similarity). Acts as a TFAP2A-mediated transcriptional coactivator in presence of CITED2 (PubMed:12586840). Plays a role as a coactivator of NEUROD1-dependent transcription of the secretin and p21 genes and controls terminal differentiation of cells in the intestinal epithelium. Promotes cardiac myocyte enlargement. Can also mediate transcriptional repression. Acetylates FOXO1 and enhances its transcriptional activity (PubMed:15890677). Acetylates BCL6 wich disrupts its ability to recruit histone deacetylases and hinders its transcriptional repressor activity (PubMed:12402037). Participates in CLOCK or NPAS2-regulated rhythmic gene transcription; exhibits a circadian association with CLOCK or NPAS2, correlating with increase in PER1/2 mRNA and histone H3 acetylation on the PER1/2 promoter (PubMed:14645221). Acetylates MTA1 at 'Lys-626' which is essential for its transcriptional coactivator activity (PubMed:16617102). Acetylates XBP1 isoform 2; acetylation increases protein stability of XBP1 isoform 2 and enhances its transcriptional activity (PubMed:20955178). Acetylates PCNA; acetylation promotes removal of chromatin-bound PCNA and its degradation during nucleotide excision repair (NER) (PubMed:24939902). Acetylates MEF2D (PubMed:21030595). Acetylates and stabilizes ZBTB7B protein by antagonizing ubiquitin conjugation and degradation, this mechanism may be involved in CD4/CD8 lineage differentiation (PubMed:20810990). Acetylates GABPB1, impairing GABPB1 heterotetramerization and activity (By similarity). Acetylates PCK1 and promotes PCK1 anaplerotic activity (PubMed:30193097). Acetylates RXRA and RXRG (PubMed:17761950). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA), butanoyl-CoA (butyryl-CoA), 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA), lactoyl-CoA or propanoyl-CoA (propionyl-CoA), and is able to mediate protein crotonylation, butyrylation, 2-hydroxyisobutyrylation, lactylation or propionylation, respectively (PubMed:17267393, PubMed:25818647, PubMed:29775581, PubMed:31645732). Acts as a histone crotonyltransferase; crotonylation marks active promoters and enhancers and confers resistance to transcriptional repressors (PubMed:25818647). Histone crotonyltransferase activity is dependent on the concentration of (2E)-butenoyl-CoA (crotonyl-CoA) substrate and such activity is weak when (2E)-butenoyl-CoA (crotonyl-CoA) concentration is low (PubMed:25818647). Also acts as a histone butyryltransferase; butyrylation marks active promoters (PubMed:17267393). Catalyzes histone lactylation in macrophages by using lactoyl-CoA directly derived from endogenous or exogenous lactate, leading to stimulates gene transcription (PubMed:31645732). Acts as a protein-lysine 2-hydroxyisobutyryltransferase; regulates glycolysis by mediating 2-hydroxyisobutyrylation of glycolytic enzymes (PubMed:29775581). Functions as a transcriptional coactivator for SMAD4 in the TGF-beta signaling pathway (PubMed:25514493). {ECO:0000250|UniProtKB:B2RWS6, ECO:0000269|PubMed:10733570, ECO:0000269|PubMed:11430825, ECO:0000269|PubMed:11511361, ECO:0000269|PubMed:11701890, ECO:0000269|PubMed:12402037, ECO:0000269|PubMed:12586840, ECO:0000269|PubMed:12929931, ECO:0000269|PubMed:14645221, ECO:0000269|PubMed:15186775, ECO:0000269|PubMed:15448695, ECO:0000269|PubMed:15890677, ECO:0000269|PubMed:16617102, ECO:0000269|PubMed:16762839, ECO:0000269|PubMed:17267393, ECO:0000269|PubMed:17761950, ECO:0000269|PubMed:18451878, ECO:0000269|PubMed:18722353, ECO:0000269|PubMed:18995842, ECO:0000269|PubMed:20810990, ECO:0000269|PubMed:21030595, ECO:0000269|PubMed:23415232, ECO:0000269|PubMed:23911289, ECO:0000269|PubMed:23934153, ECO:0000269|PubMed:24939902, ECO:0000269|PubMed:25514493, ECO:0000269|PubMed:25818647, ECO:0000269|PubMed:29775581, ECO:0000269|PubMed:30193097, ECO:0000269|PubMed:31645732, ECO:0000269|PubMed:8945521, ECO:0000305|PubMed:20955178}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, it is recruited by the viral protein Tat. Regulates Tat's transactivating activity and may help inducing chromatin remodeling of proviral genes. Binds to and may be involved in the transforming capacity of the adenovirus E1A protein. {ECO:0000269|PubMed:10545121, ECO:0000269|PubMed:11080476}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF17chr11:73022875chr22:41545041ENST00000263674+121201_20410642064.0Compositional biasNote=Poly-Gln
HgeneARHGEF17chr11:73022875chr22:41545041ENST00000263674+121230_23510642064.0Compositional biasNote=Poly-Ser
HgeneARHGEF17chr11:73022875chr22:41545041ENST00000263674+121252_25610642064.0Compositional biasNote=Poly-Glu
HgeneARHGEF17chr11:73022875chr22:41545041ENST00000263674+121566_56910642064.0Compositional biasNote=Poly-Ser
HgeneARHGEF17chr11:73022875chr22:41545041ENST00000263674+121672_67510642064.0Compositional biasNote=Poly-Ser
HgeneARHGEF17chr11:73022875chr22:41545041ENST00000263674+121707_71010642064.0Compositional biasNote=Poly-Arg
HgeneARHGEF17chr11:73022875chr22:41545041ENST00000263674+121963_105410642064.0Compositional biasNote=Pro-rich
HgeneARHGEF17chr11:73022875chr22:41545042ENST00000263674+121201_20410642064.0Compositional biasNote=Poly-Gln
HgeneARHGEF17chr11:73022875chr22:41545042ENST00000263674+121230_23510642064.0Compositional biasNote=Poly-Ser
HgeneARHGEF17chr11:73022875chr22:41545042ENST00000263674+121252_25610642064.0Compositional biasNote=Poly-Glu
HgeneARHGEF17chr11:73022875chr22:41545042ENST00000263674+121566_56910642064.0Compositional biasNote=Poly-Ser
HgeneARHGEF17chr11:73022875chr22:41545042ENST00000263674+121672_67510642064.0Compositional biasNote=Poly-Ser
HgeneARHGEF17chr11:73022875chr22:41545042ENST00000263674+121707_71010642064.0Compositional biasNote=Poly-Arg
HgeneARHGEF17chr11:73022875chr22:41545042ENST00000263674+121963_105410642064.0Compositional biasNote=Pro-rich
TgeneEP300chr11:73022875chr22:41545041ENST0000026325311311519_15267472415.0Compositional biasNote=Poly-Glu
TgeneEP300chr11:73022875chr22:41545041ENST0000026325311312066_20697472415.0Compositional biasNote=Poly-Gln
TgeneEP300chr11:73022875chr22:41545041ENST0000026325311312190_21957472415.0Compositional biasNote=Poly-Gln
TgeneEP300chr11:73022875chr22:41545041ENST000002632531131797_8007472415.0Compositional biasNote=Poly-Ser
TgeneEP300chr11:73022875chr22:41545042ENST0000026325311311519_15267472415.0Compositional biasNote=Poly-Glu
TgeneEP300chr11:73022875chr22:41545042ENST0000026325311312066_20697472415.0Compositional biasNote=Poly-Gln
TgeneEP300chr11:73022875chr22:41545042ENST0000026325311312190_21957472415.0Compositional biasNote=Poly-Gln
TgeneEP300chr11:73022875chr22:41545042ENST000002632531131797_8007472415.0Compositional biasNote=Poly-Ser
TgeneEP300chr11:73022875chr22:41545041ENST0000026325311311067_11397472415.0DomainBromo
TgeneEP300chr11:73022875chr22:41545041ENST0000026325311311287_16637472415.0DomainCBP/p300-type HAT
TgeneEP300chr11:73022875chr22:41545042ENST0000026325311311067_11397472415.0DomainBromo
TgeneEP300chr11:73022875chr22:41545042ENST0000026325311311287_16637472415.0DomainCBP/p300-type HAT
TgeneEP300chr11:73022875chr22:41545041ENST0000026325311311017_10297472415.0RegionNote=CRD1%3B mediates transcriptional repression
TgeneEP300chr11:73022875chr22:41545041ENST0000026325311311398_14007472415.0RegionAcetyl-CoA binding
TgeneEP300chr11:73022875chr22:41545041ENST0000026325311311410_14117472415.0RegionAcetyl-CoA binding
TgeneEP300chr11:73022875chr22:41545041ENST0000026325311311572_18187472415.0RegionNote=Binding region for E1A adenovirus
TgeneEP300chr11:73022875chr22:41545042ENST0000026325311311017_10297472415.0RegionNote=CRD1%3B mediates transcriptional repression
TgeneEP300chr11:73022875chr22:41545042ENST0000026325311311398_14007472415.0RegionAcetyl-CoA binding
TgeneEP300chr11:73022875chr22:41545042ENST0000026325311311410_14117472415.0RegionAcetyl-CoA binding
TgeneEP300chr11:73022875chr22:41545042ENST0000026325311311572_18187472415.0RegionNote=Binding region for E1A adenovirus
TgeneEP300chr11:73022875chr22:41545041ENST0000026325311311664_17077472415.0Zinc fingerZZ-type
TgeneEP300chr11:73022875chr22:41545041ENST0000026325311311728_18097472415.0Zinc fingerTAZ-type 2
TgeneEP300chr11:73022875chr22:41545042ENST0000026325311311664_17077472415.0Zinc fingerZZ-type
TgeneEP300chr11:73022875chr22:41545042ENST0000026325311311728_18097472415.0Zinc fingerTAZ-type 2

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGEF17chr11:73022875chr22:41545041ENST00000263674+1211990_199610642064.0Compositional biasNote=Poly-Pro
HgeneARHGEF17chr11:73022875chr22:41545042ENST00000263674+1211990_199610642064.0Compositional biasNote=Poly-Pro
HgeneARHGEF17chr11:73022875chr22:41545041ENST00000263674+1211066_125410642064.0DomainDH
HgeneARHGEF17chr11:73022875chr22:41545042ENST00000263674+1211066_125410642064.0DomainDH
TgeneEP300chr11:73022875chr22:41545041ENST000002632531131566_6457472415.0DomainKIX
TgeneEP300chr11:73022875chr22:41545042ENST000002632531131566_6457472415.0DomainKIX
TgeneEP300chr11:73022875chr22:41545041ENST00000263253113111_177472415.0MotifNuclear localization signal
TgeneEP300chr11:73022875chr22:41545042ENST00000263253113111_177472415.0MotifNuclear localization signal
TgeneEP300chr11:73022875chr22:41545041ENST000002632531131331_4177472415.0Zinc fingerTAZ-type 1
TgeneEP300chr11:73022875chr22:41545042ENST000002632531131331_4177472415.0Zinc fingerTAZ-type 1


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Fusion Gene Sequence for ARHGEF17-EP300


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6228_6228_1_ARHGEF17-EP300_ARHGEF17_chr11_73022875_ENST00000263674_EP300_chr22_41545041_ENST00000263253_length(transcript)=9667nt_BP=3542nt
GAGCGAGCAGCCAAGGGCGTTGGGCAGGCGGACGCAGAGTCGAGGAACCAAGCGCTGGGATCCCGCCCAGGCGGTGCCGCGGTGCCCCTG
GTCGCTCCAGCCGCGGCGGGGGCTGGGCCTGGGGGTCGGCGCTGAGGCGGGAGGGGCCGCCCGGGATGGAGACGTTGCGGCCGGTGGCCA
CAGAAACTTGAGCCGCGGCAGAGAAACCTCTGCTCCGGTCTCTGCGTCCTCTTCCCACACTCCCGTGCGCTGCTTTCGGCGTGGGCCGCT
GCGCTCCTAGGGAGTGGGGGCGCAGGGGGGGTTGGCCGCGGCTGCCCGAGGCCAGCCCCCCCGGAGTGAGTTACGCCACTATGGCGGACG
GGGCACCCCGGCCCCAGCTTTACCGCAGCGTCTCGTTCAAGCTGCTGGAGCGCTGGAGCGGCGGCCCCGGGCTGAGGGAGGAGGACACGG
ACACCCCCGGCTTGAGGCGACGCGCCTCGTGCCGGCCGACCACGGCTGCCCGGGGCCAGCCCTCTCGGCGCGTGTCCAAGCTGGCGTCTG
GGCCCCTGGCCGCCCCCGCGCAGCCGCGCCCGCTCCGCAGCCTCTCGCCGTCGGTTCGCCAGCTCTCCCGGCGCTTCGACGCGCCGCGTC
TGGACGACGGCTCCGCTGGGACCCGAGACGGAGGCGTCTTACCCGCGGCCGCGGAAGAAGCGGCCGAGGGCCCAGCGCGAGGAGCCTGGC
CCAGCGTCACCGAGATGCGCAAGCTCTTCGGCGGTCCTGGCTCCAGGAGGCCCAGCGCCGACTCTGAATCCCCAGGAACGCCCAGCCCCG
ACGGTGCCGCGTGGGAGCCTCCGGCTCGGGAGTCGCGGCAGCCACCGACGCCACCCCCTCGGACATGCTTCCCCCTGGCGGGTCTGCGTT
CGGCGCGGCCCCTGACCGGGCCGGAGACCGAAGGGAGGCTGCGCCGGCCGCAGCAGCAACAGGAGCGGGCGCAGCGTCCAGCGGATGGTT
TACATTCTTGGCATATCTTCTCCCAACCGCAGGCCGGGGCCCGGGCCTCCTGCTCCTCCTCCTCCATCGCCGCCTCCTATCCTGTCAGCC
GCAGTCGTGCTGCCAGCTCCAGCGAGGAGGAAGAGGAGGGCCCGCCGCAGCTGCCTGGAGCCCAGAGTCCGGCCTACCACGGCGGCCACT
CCTCGGGCAGTGACGACGACCGAGACGGTGAGGGCGGCCACCGCTGGGGAGGGAGGCCCGGGCTCAGGCCTGGAAGCTCCCTATTGGATC
AGGACTGCAGGCCTGACAGTGATGGGTTAAATCTAAGCAGCATGAACTCAGCAGGGGTTTCTGGGAGCCCTGAGCCCCCAACATCTCCAA
GAGCCCCTAGAGAAGAAGGACTCCGGGAGTGGGGTAGTGGCTCTCCGCCCTGCGTCCCAGGTCCCCAGGAGGGACTTCGGCCTATGTCTG
ACTCTGTGGGAGGAGCTTTCCGTGTGGCCAAGGTGAGCTTTCCCTCGTACCTGGCCAGCCCCGCAGGCTCCCGCGGTAGCAGCCGTTATT
CCAGCACGGAGACCCTCAAGGACGACGACCTATGGTCTAGTAGGGGTTCTGGGGGCTGGGGCGTGTACCGCTCCCCTAGCTTTGGAGCTG
GGGAAGGGCTCCTGCGGTCCCAGGCTCGAACCCGTGCCAAAGGACCTGGAGGCACCTCTAGGGCATTGAGGGATGGAGGATTTGAGCCTG
AAAAGAGTCGACAGCGGAAGTCCCTGTCAAATCCAGATATCGCCTCAGAGACCCTGACGCTTCTCAGTTTCCTGCGCTCAGACCTTTCAG
AGCTGAGGGTCCGAAAACCTGGTGGGAGCTCCGGGGACCGTGGAAGCAACCCCCTAGATGGCAGAGACTCACCATCCGCAGGTGGCCCTG
TGGGGCAACTTGAACCCATACCCATCCCAGCCCCAGCATCACCTGGCACGCGCCCCACACTCAAGGACTTGACAGCCACTCTGCGGAGAG
CAAAGTCATTCACCTGCTCTGAGAAGCCCATGGCCCGCCGCCTGCCCCGCACCAGTGCTCTGAAGTCCAGCTCCTCCGAGCTCCTGCTCA
CAGGCCCTGGTGCCGAGGAGGATCCGCTGCCCCTCATCGTCCAGGACCAATATGTGCAGGAGGCCCGCCAGGTTTTTGAGAAGATCCAGC
GCATGGGTGCCCAACAAGATGATGGAAGCGATGCCCCCCCTGGAAGCCCTGACTGGGCAGGGGATGTGACCCGAGGGCAGCGGTCCCAGG
AGGAGCTCTCAGGCCCTGAGTCCAGTCTGACAGATGAAGGCATTGGGGCAGACCCTGAGCCTCCTGTTGCAGCATTTTGCGGCCTGGGTA
CCACAGGGATGTGGCGACCTCTTTCCTCATCCTCGGCCCAGACGAACCACCATGGCCCTGGGACTGAGGACAGTCTGGGCGGGTGGGCCC
TGGTGTCGCCTGAGACCCCTCCCACACCAGGTGCCCTCCGCCGACGACGCAAAGTCCCACCTTCAGGTTCTGGTGGGAGCGAATTGAGCA
ATGGGGAGGCAGGGGAGGCCTACAGGTCCCTGAGTGACCCAATTCCTCAGCGCCACCGGGCTGCCACCTCTGAAGAGCCTACTGGGTTCT
CTGTGGACAGCAACCTCCTGGGCTCACTGAGCCCCAAGACAGGGCTCCCTGCCACCTCAGCCATGGATGAGGGCTTGACCAGTGGTCACA
GTGACTGGTCTGTGGGCAGTGAAGAGAGCAAGGGATATCAGGAGGTTATTCAGAGCATAGTTCAGGGGCCTGGCACCCTGGGGCGTGTGG
TGGACGACAGGATTGCTGGCAAAGCCCCCAAGAAGAAATCCCTGAGTGACCCCAGCCGCCGTGGGGAGCTGGCTGGGCCTGGATTCGAGG
GCCCTGGAGGGGAGCCCATCCGAGAAGTTGAGCCCATGCTGCCTCCATCCAGCAGCGAGCCCATCCTTGTAGAGCAGCGGGCAGAGCCAG
AAGAACCTGGTGCCACCAGGAGCCGGGCACAGTCTGAAAGGGCCCTACCTGAGGCTCTGCCTCCCCCTGCCACTGCCCACCGAAACTTTC
ACCTTGACCCCAAGCTGGCTGACATTCTGTCCCCGAGGCTAATCCGCCGAGGCTCCAAGAAGCGCCCAGCTCGGAGTAGTCACCAGGAGC
TTCGGAGAGACGAGGGCAGTCAGGACCAGACTGGCAGCCTGTCTCGGGCCCGGCCCTCCTCCAGACACGTTCGCCATGCCAGTGTGCCCG
CCACATTTATGCCTATTGTGGTGCCTGAGCCACCAACTTCTGTTGGTCCCCCTGTGGCTGTGCCAGAACCCATAGGCTTCCCTACCCGAG
CCCATCCCACGTTGCAGGCACCATCGCTCGAGGACGTCACCAAGCAGTACATGCTGAACCTGCACTCCGGTGAGGTCCCTGCCCCAGTGC
CAGTGGACATGCCCTGCTTGCCTCTGGCTGCACCGCCCTCTGCTGAGGCCAAGCCCCCTGAGGCAGCTCGGCCTGCAGATGAGCCTACCC
CTGCCAGCAAGTGCTGCAGCAAGCCACAGGTGCCTATGGGCTATGGGCCTCGTATGCAACAGCCTTCCAACCAGGGCCAGTTCCTTCCTC
AGACTCAGTTCCCATCACAGGGAATGAATGTAACAAATATCCCTTTGGCTCCGTCCAGCGGTCAAGCTCCAGTGTCTCAAGCACAAATGT
CTAGTTCTTCCTGCCCGGTGAACTCTCCTATAATGCCTCCAGGGTCTCAGGGGAGCCACATTCACTGTCCCCAGCTTCCTCAACCAGCTC
TTCATCAGAATTCACCCTCGCCTGTACCTAGTCGTACCCCCACCCCTCACCATACTCCCCCAAGCATAGGGGCTCAGCAGCCACCAGCAA
CAACAATTCCAGCCCCTGTTCCTACACCTCCTGCCATGCCACCTGGGCCACAGTCCCAGGCTCTACATCCCCCTCCAAGGCAGACACCTA
CACCACCAACAACACAACTTCCCCAACAAGTGCAGCCTTCACTTCCTGCTGCACCTTCTGCTGACCAGCCCCAGCAGCAGCCTCGCTCAC
AGCAGAGCACAGCAGCGTCTGTTCCTACCCCAACAGCACCGCTGCTTCCTCCGCAGCCTGCAACTCCACTTTCCCAGCCAGCTGTAAGCA
TTGAAGGACAGGTATCAAATCCTCCATCTACTAGTAGCACAGAAGTGAATTCTCAGGCCATTGCTGAGAAGCAGCCTTCCCAGGAAGTGA
AGATGGAGGCCAAAATGGAAGTGGATCAACCAGAACCAGCAGATACTCAGCCGGAGGATATTTCAGAGTCTAAAGTGGAAGACTGTAAAA
TGGAATCTACCGAAACAGAAGAGAGAAGCACTGAGTTAAAAACTGAAATAAAAGAGGAGGAAGACCAGCCAAGTACTTCAGCTACCCAGT
CATCTCCGGCTCCAGGACAGTCAAAGAAAAAGATTTTCAAACCAGAAGAACTACGACAGGCACTGATGCCAACTTTGGAGGCACTTTACC
GTCAGGATCCAGAATCCCTTCCCTTTCGTCAACCTGTGGACCCTCAGCTTTTAGGAATCCCTGATTACTTTGATATTGTGAAGAGCCCCA
TGGATCTTTCTACCATTAAGAGGAAGTTAGACACTGGACAGTATCAGGAGCCCTGGCAGTATGTCGATGATATTTGGCTTATGTTCAATA
ATGCCTGGTTATATAACCGGAAAACATCACGGGTATACAAATACTGCTCCAAGCTCTCTGAGGTCTTTGAACAAGAAATTGACCCAGTGA
TGCAAAGCCTTGGATACTGTTGTGGCAGAAAGTTGGAGTTCTCTCCACAGACACTGTGTTGCTACGGCAAACAGTTGTGCACAATACCTC
GTGATGCCACTTATTACAGTTACCAGAACAGGTATCATTTCTGTGAGAAGTGTTTCAATGAGATCCAAGGGGAGAGCGTTTCTTTGGGGG
ATGACCCTTCCCAGCCTCAAACTACAATAAATAAAGAACAATTTTCCAAGAGAAAAAATGACACACTGGATCCTGAACTGTTTGTTGAAT
GTACAGAGTGCGGAAGAAAGATGCATCAGATCTGTGTCCTTCACCATGAGATCATCTGGCCTGCTGGATTCGTCTGTGATGGCTGTTTAA
AGAAAAGTGCACGAACTAGGAAAGAAAATAAGTTTTCTGCTAAAAGGTTGCCATCTACCAGACTTGGCACCTTTCTAGAGAATCGTGTGA
ATGACTTTCTGAGGCGACAGAATCACCCTGAGTCAGGAGAGGTCACTGTTAGAGTAGTTCATGCTTCTGACAAAACCGTGGAAGTAAAAC
CAGGCATGAAAGCAAGGTTTGTGGACAGTGGAGAGATGGCAGAATCCTTTCCATACCGAACCAAAGCCCTCTTTGCCTTTGAAGAAATTG
ATGGTGTTGACCTGTGCTTCTTTGGCATGCATGTTCAAGAGTATGGCTCTGACTGCCCTCCACCCAACCAGAGGAGAGTATACATATCTT
ACCTCGATAGTGTTCATTTCTTCCGTCCTAAATGCTTGAGGACTGCAGTCTATCATGAAATCCTAATTGGATATTTAGAATATGTCAAGA
AATTAGGTTACACAACAGGGCATATTTGGGCATGTCCACCAAGTGAGGGAGATGATTATATCTTCCATTGCCATCCTCCTGACCAGAAGA
TACCCAAGCCCAAGCGACTGCAGGAATGGTACAAAAAAATGCTTGACAAGGCTGTATCAGAGCGTATTGTCCATGACTACAAGGATATTT
TTAAACAAGCTACTGAAGATAGATTAACAAGTGCAAAGGAATTGCCTTATTTCGAGGGTGATTTCTGGCCCAATGTTCTGGAAGAAAGCA
TTAAGGAACTGGAACAGGAGGAAGAAGAGAGAAAACGAGAGGAAAACACCAGCAATGAAAGCACAGATGTGACCAAGGGAGACAGCAAAA
ATGCTAAAAAGAAGAATAATAAGAAAACCAGCAAAAATAAGAGCAGCCTGAGTAGGGGCAACAAGAAGAAACCCGGGATGCCCAATGTAT
CTAACGACCTCTCACAGAAACTATATGCCACCATGGAGAAGCATAAAGAGGTCTTCTTTGTGATCCGCCTCATTGCTGGCCCTGCTGCCA
ACTCCCTGCCTCCCATTGTTGATCCTGATCCTCTCATCCCCTGCGATCTGATGGATGGTCGGGATGCGTTTCTCACGCTGGCAAGGGACA
AGCACCTGGAGTTCTCTTCACTCCGAAGAGCCCAGTGGTCCACCATGTGCATGCTGGTGGAGCTGCACACGCAGAGCCAGGACCGCTTTG
TCTACACCTGCAATGAATGCAAGCACCATGTGGAGACACGCTGGCACTGTACTGTCTGTGAGGATTATGACTTGTGTATCACCTGCTATA
ACACTAAAAACCATGACCACAAAATGGAGAAACTAGGCCTTGGCTTAGATGATGAGAGCAACAACCAGCAGGCTGCAGCCACCCAGAGCC
CAGGCGATTCTCGCCGCCTGAGTATCCAGCGCTGCATCCAGTCTCTGGTCCATGCTTGCCAGTGTCGGAATGCCAATTGCTCACTGCCAT
CCTGCCAGAAGATGAAGCGGGTTGTGCAGCATACCAAGGGTTGCAAACGGAAAACCAATGGCGGGTGCCCCATCTGCAAGCAGCTCATTG
CCCTCTGCTGCTACCATGCCAAGCACTGCCAGGAGAACAAATGCCCGGTGCCGTTCTGCCTAAACATCAAGCAGAAGCTCCGGCAGCAAC
AGCTGCAGCACCGACTACAGCAGGCCCAAATGCTTCGCAGGAGGATGGCCAGCATGCAGCGGACTGGTGTGGTTGGGCAGCAACAGGGCC
TCCCTTCCCCCACTCCTGCCACTCCAACGACACCAACTGGCCAACAGCCAACCACCCCGCAGACGCCCCAGCCCACTTCTCAGCCTCAGC
CTACCCCTCCCAATAGCATGCCACCCTACTTGCCCAGGACTCAAGCTGCTGGCCCTGTGTCCCAGGGTAAGGCAGCAGGCCAGGTGACCC
CTCCAACCCCTCCTCAGACTGCTCAGCCACCCCTTCCAGGGCCCCCACCTGCAGCAGTGGAAATGGCAATGCAGATTCAGAGAGCAGCGG
AGACGCAGCGCCAGATGGCCCACGTGCAAATTTTTCAAAGGCCAATCCAACACCAGATGCCCCCGATGACTCCCATGGCCCCCATGGGTA
TGAACCCACCTCCCATGACCAGAGGTCCCAGTGGGCATTTGGAGCCAGGGATGGGACCGACAGGGATGCAGCAACAGCCACCCTGGAGCC
AAGGAGGATTGCCTCAGCCCCAGCAACTACAGTCTGGGATGCCAAGGCCAGCCATGATGTCAGTGGCCCAGCATGGTCAACCTTTGAACA
TGGCTCCACAACCAGGATTGGGCCAGGTAGGTATCAGCCCACTCAAACCAGGCACTGTGTCTCAACAAGCCTTACAAAACCTTTTGCGGA
CTCTCAGGTCTCCCAGCTCTCCCCTGCAGCAGCAACAGGTGCTTAGTATCCTTCACGCCAACCCCCAGCTGTTGGCTGCATTCATCAAGC
AGCGGGCTGCCAAGTATGCCAACTCTAATCCACAACCCATCCCTGGGCAGCCTGGCATGCCCCAGGGGCAGCCAGGGCTACAGCCACCTA
CCATGCCAGGTCAGCAGGGGGTCCACTCCAATCCAGCCATGCAGAACATGAATCCAATGCAGGCGGGCGTTCAGAGGGCTGGCCTGCCCC
AGCAGCAACCACAGCAGCAACTCCAGCCACCCATGGGAGGGATGAGCCCCCAGGCTCAGCAGATGAACATGAACCACAACACCATGCCTT
CACAATTCCGAGACATCTTGAGACGACAGCAAATGATGCAACAGCAGCAGCAACAGGGAGCAGGGCCAGGAATAGGCCCTGGAATGGCCA
ACCATAACCAGTTCCAGCAACCCCAAGGAGTTGGCTACCCACCACAGCAGCAGCAGCGGATGCAGCATCACATGCAACAGATGCAACAAG
GAAATATGGGACAGATAGGCCAGCTTCCCCAGGCCTTGGGAGCAGAGGCAGGTGCCAGTCTACAGGCCTATCAGCAGCGACTCCTTCAGC
AACAGATGGGGTCCCCTGTTCAGCCCAACCCCATGAGCCCCCAGCAGCATATGCTCCCAAATCAGGCCCAGTCCCCACACCTACAAGGCC
AGCAGATCCCTAATTCTCTCTCCAATCAAGTGCGCTCTCCCCAGCCTGTCCCTTCTCCACGGCCACAGTCCCAGCCCCCCCACTCCAGTC
CTTCCCCAAGGATGCAGCCTCAGCCTTCTCCACACCACGTTTCCCCACAGACAAGTTCCCCACATCCTGGACTGGTAGCTGCCCAGGCCA
ACCCCATGGAACAAGGGCATTTTGCCAGCCCGGACCAGAATTCAATGCTTTCTCAGCTTGCTAGCAATCCAGGCATGGCAAACCTCCATG
GTGCAAGCGCCACGGACCTGGGACTCAGCACCGATAACTCAGACTTGAATTCAAACCTCTCACAGAGTACACTAGACATACACTAGAGAC
ACCTTGTAGTATTTTGGGAGCAAAAAAATTATTTTCTCTTAACAAGACTTTTTGTACTGAAAACAATTTTTTTGAATCTTTCGTAGCCTA
AAAGACAATTTTCCTTGGAACACATAAGAACTGTGCAGTAGCCGTTTGTGGTTTAAAGCAAACATGCAAGATGAACCTGAGGGATGATAG
AATACAAAGAATATATTTTTGTTATGGCTGGTTACCACCAGCCTTTCTTCCCCTTTGTGTGTGTGGTTCAAGTGTGCACTGGGAGGAGGC
TGAGGCCTGTGAAGCCAAACAATATGCTCCTGCCTTGCACCTCCAATAGGTTTTATTATTTTTTTTAAATTAATGAACATATGTAATATT
AATAGTTATTATTTACTGGTGCAGATGGTTGACATTTTTCCCTATTTTCCTCACTTTATGGAAGAGTTAAAACATTTCTAAACCAGAGGA
CAAAAGGGGTTAATGTTACTTTAAAATTACATTCTATATATATATAAATATATATAAATATATATTAAAATACCAGTTTTTTTTCTCTGG
GTGCAAAGATGTTCATTCTTTTAAAAAATGTTTAAAAAAAAAAAAAAACTGCCTTTCTTCCCCTCAAGTCAACTTTTGTGCTCCAGAAAA
TTTTCTATTCTGTAAGTCTGAGCGTAAAACTTCAAGTATTAAAATAATTTGTACATGTAGAGAGAAAAATGACTTTTTCAAAAATATACA
GGGGCAGCTGCCAAATTGATGTATTATATATTGTGGTTTCTGTTTCTTGAAAGAATTTTTTTCGTTATTTTTACATCTAACAAAGTAAAA
AAATTAAAAAGAGGGTAAGAAACGATTCCGGTGGGATGATTTTAACATGCAAAATGTCCCTGGGGGTTTCTTCTTTGCTTGCTTTCTTCC
TCCTTACCCTACCCCCCACTCACACACACACACACACACACACACACACACACACACACACACTTTCTATAAAACTTGAAAATAGCAAAA
ACCCTCAACTGTTGTAAATCATGCAATTAAAGTTGATTACTTATAAATATGAACTTTGGATCACTGTATAGACTGTTAAATTTGATTTCT

>6228_6228_1_ARHGEF17-EP300_ARHGEF17_chr11_73022875_ENST00000263674_EP300_chr22_41545041_ENST00000263253_length(amino acids)=2778AA_BP=1111
MLRSLRPLPTLPCAAFGVGRCAPREWGRRGGWPRLPEASPPGVSYATMADGAPRPQLYRSVSFKLLERWSGGPGLREEDTDTPGLRRRAS
CRPTTAARGQPSRRVSKLASGPLAAPAQPRPLRSLSPSVRQLSRRFDAPRLDDGSAGTRDGGVLPAAAEEAAEGPARGAWPSVTEMRKLF
GGPGSRRPSADSESPGTPSPDGAAWEPPARESRQPPTPPPRTCFPLAGLRSARPLTGPETEGRLRRPQQQQERAQRPADGLHSWHIFSQP
QAGARASCSSSSIAASYPVSRSRAASSSEEEEEGPPQLPGAQSPAYHGGHSSGSDDDRDGEGGHRWGGRPGLRPGSSLLDQDCRPDSDGL
NLSSMNSAGVSGSPEPPTSPRAPREEGLREWGSGSPPCVPGPQEGLRPMSDSVGGAFRVAKVSFPSYLASPAGSRGSSRYSSTETLKDDD
LWSSRGSGGWGVYRSPSFGAGEGLLRSQARTRAKGPGGTSRALRDGGFEPEKSRQRKSLSNPDIASETLTLLSFLRSDLSELRVRKPGGS
SGDRGSNPLDGRDSPSAGGPVGQLEPIPIPAPASPGTRPTLKDLTATLRRAKSFTCSEKPMARRLPRTSALKSSSSELLLTGPGAEEDPL
PLIVQDQYVQEARQVFEKIQRMGAQQDDGSDAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSS
SSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGSELSNGEAGEAYRSLSDPIPQRHRAATSEEPTGFSVDSNLLGSL
SPKTGLPATSAMDEGLTSGHSDWSVGSEESKGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREV
EPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNFHLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQ
TGSLSRARPSSRHVRHASVPATFMPIVVPEPPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLA
APPSAEAKPPEAARPADEPTPASKCCSKPQVPMGYGPRMQQPSNQGQFLPQTQFPSQGMNVTNIPLAPSSGQAPVSQAQMSSSSCPVNSP
IMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIGAQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQ
VQPSLPAAPSADQPQQQPRSQQSTAASVPTPTAPLLPPQPATPLSQPAVSIEGQVSNPPSTSSTEVNSQAIAEKQPSQEVKMEAKMEVDQ
PEPADTQPEDISESKVEDCKMESTETEERSTELKTEIKEEEDQPSTSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFR
QPVDPQLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGYCCGR
KLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQ
ICVLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDS
GEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIW
ACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEE
RKREENTSNESTDVTKGDSKNAKKKNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIAGPAANSLPPIVDPD
PLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVYTCNECKHHVETRWHCTVCEDYDLCITCYNTKNHDHKME
KLGLGLDDESNNQQAAATQSPGDSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHC
QENKCPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVGQQQGLPSPTPATPTTPTGQQPTTPQTPQPTSQPQPTPPNSMPPY
LPRTQAAGPVSQGKAAGQVTPPTPPQTAQPPLPGPPPAAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQMPPMTPMAPMGMNPPPMTRGP
SGHLEPGMGPTGMQQQPPWSQGGLPQPQQLQSGMPRPAMMSVAQHGQPLNMAPQPGLGQVGISPLKPGTVSQQALQNLLRTLRSPSSPLQ
QQQVLSILHANPQLLAAFIKQRAAKYANSNPQPIPGQPGMPQGQPGLQPPTMPGQQGVHSNPAMQNMNPMQAGVQRAGLPQQQPQQQLQP
PMGGMSPQAQQMNMNHNTMPSQFRDILRRQQMMQQQQQQGAGPGIGPGMANHNQFQQPQGVGYPPQQQQRMQHHMQQMQQGNMGQIGQLP
QALGAEAGASLQAYQQRLLQQQMGSPVQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQVRSPQPVPSPRPQSQPPHSSPSPRMQPQPS

--------------------------------------------------------------
>6228_6228_2_ARHGEF17-EP300_ARHGEF17_chr11_73022875_ENST00000263674_EP300_chr22_41545042_ENST00000263253_length(transcript)=9667nt_BP=3542nt
GAGCGAGCAGCCAAGGGCGTTGGGCAGGCGGACGCAGAGTCGAGGAACCAAGCGCTGGGATCCCGCCCAGGCGGTGCCGCGGTGCCCCTG
GTCGCTCCAGCCGCGGCGGGGGCTGGGCCTGGGGGTCGGCGCTGAGGCGGGAGGGGCCGCCCGGGATGGAGACGTTGCGGCCGGTGGCCA
CAGAAACTTGAGCCGCGGCAGAGAAACCTCTGCTCCGGTCTCTGCGTCCTCTTCCCACACTCCCGTGCGCTGCTTTCGGCGTGGGCCGCT
GCGCTCCTAGGGAGTGGGGGCGCAGGGGGGGTTGGCCGCGGCTGCCCGAGGCCAGCCCCCCCGGAGTGAGTTACGCCACTATGGCGGACG
GGGCACCCCGGCCCCAGCTTTACCGCAGCGTCTCGTTCAAGCTGCTGGAGCGCTGGAGCGGCGGCCCCGGGCTGAGGGAGGAGGACACGG
ACACCCCCGGCTTGAGGCGACGCGCCTCGTGCCGGCCGACCACGGCTGCCCGGGGCCAGCCCTCTCGGCGCGTGTCCAAGCTGGCGTCTG
GGCCCCTGGCCGCCCCCGCGCAGCCGCGCCCGCTCCGCAGCCTCTCGCCGTCGGTTCGCCAGCTCTCCCGGCGCTTCGACGCGCCGCGTC
TGGACGACGGCTCCGCTGGGACCCGAGACGGAGGCGTCTTACCCGCGGCCGCGGAAGAAGCGGCCGAGGGCCCAGCGCGAGGAGCCTGGC
CCAGCGTCACCGAGATGCGCAAGCTCTTCGGCGGTCCTGGCTCCAGGAGGCCCAGCGCCGACTCTGAATCCCCAGGAACGCCCAGCCCCG
ACGGTGCCGCGTGGGAGCCTCCGGCTCGGGAGTCGCGGCAGCCACCGACGCCACCCCCTCGGACATGCTTCCCCCTGGCGGGTCTGCGTT
CGGCGCGGCCCCTGACCGGGCCGGAGACCGAAGGGAGGCTGCGCCGGCCGCAGCAGCAACAGGAGCGGGCGCAGCGTCCAGCGGATGGTT
TACATTCTTGGCATATCTTCTCCCAACCGCAGGCCGGGGCCCGGGCCTCCTGCTCCTCCTCCTCCATCGCCGCCTCCTATCCTGTCAGCC
GCAGTCGTGCTGCCAGCTCCAGCGAGGAGGAAGAGGAGGGCCCGCCGCAGCTGCCTGGAGCCCAGAGTCCGGCCTACCACGGCGGCCACT
CCTCGGGCAGTGACGACGACCGAGACGGTGAGGGCGGCCACCGCTGGGGAGGGAGGCCCGGGCTCAGGCCTGGAAGCTCCCTATTGGATC
AGGACTGCAGGCCTGACAGTGATGGGTTAAATCTAAGCAGCATGAACTCAGCAGGGGTTTCTGGGAGCCCTGAGCCCCCAACATCTCCAA
GAGCCCCTAGAGAAGAAGGACTCCGGGAGTGGGGTAGTGGCTCTCCGCCCTGCGTCCCAGGTCCCCAGGAGGGACTTCGGCCTATGTCTG
ACTCTGTGGGAGGAGCTTTCCGTGTGGCCAAGGTGAGCTTTCCCTCGTACCTGGCCAGCCCCGCAGGCTCCCGCGGTAGCAGCCGTTATT
CCAGCACGGAGACCCTCAAGGACGACGACCTATGGTCTAGTAGGGGTTCTGGGGGCTGGGGCGTGTACCGCTCCCCTAGCTTTGGAGCTG
GGGAAGGGCTCCTGCGGTCCCAGGCTCGAACCCGTGCCAAAGGACCTGGAGGCACCTCTAGGGCATTGAGGGATGGAGGATTTGAGCCTG
AAAAGAGTCGACAGCGGAAGTCCCTGTCAAATCCAGATATCGCCTCAGAGACCCTGACGCTTCTCAGTTTCCTGCGCTCAGACCTTTCAG
AGCTGAGGGTCCGAAAACCTGGTGGGAGCTCCGGGGACCGTGGAAGCAACCCCCTAGATGGCAGAGACTCACCATCCGCAGGTGGCCCTG
TGGGGCAACTTGAACCCATACCCATCCCAGCCCCAGCATCACCTGGCACGCGCCCCACACTCAAGGACTTGACAGCCACTCTGCGGAGAG
CAAAGTCATTCACCTGCTCTGAGAAGCCCATGGCCCGCCGCCTGCCCCGCACCAGTGCTCTGAAGTCCAGCTCCTCCGAGCTCCTGCTCA
CAGGCCCTGGTGCCGAGGAGGATCCGCTGCCCCTCATCGTCCAGGACCAATATGTGCAGGAGGCCCGCCAGGTTTTTGAGAAGATCCAGC
GCATGGGTGCCCAACAAGATGATGGAAGCGATGCCCCCCCTGGAAGCCCTGACTGGGCAGGGGATGTGACCCGAGGGCAGCGGTCCCAGG
AGGAGCTCTCAGGCCCTGAGTCCAGTCTGACAGATGAAGGCATTGGGGCAGACCCTGAGCCTCCTGTTGCAGCATTTTGCGGCCTGGGTA
CCACAGGGATGTGGCGACCTCTTTCCTCATCCTCGGCCCAGACGAACCACCATGGCCCTGGGACTGAGGACAGTCTGGGCGGGTGGGCCC
TGGTGTCGCCTGAGACCCCTCCCACACCAGGTGCCCTCCGCCGACGACGCAAAGTCCCACCTTCAGGTTCTGGTGGGAGCGAATTGAGCA
ATGGGGAGGCAGGGGAGGCCTACAGGTCCCTGAGTGACCCAATTCCTCAGCGCCACCGGGCTGCCACCTCTGAAGAGCCTACTGGGTTCT
CTGTGGACAGCAACCTCCTGGGCTCACTGAGCCCCAAGACAGGGCTCCCTGCCACCTCAGCCATGGATGAGGGCTTGACCAGTGGTCACA
GTGACTGGTCTGTGGGCAGTGAAGAGAGCAAGGGATATCAGGAGGTTATTCAGAGCATAGTTCAGGGGCCTGGCACCCTGGGGCGTGTGG
TGGACGACAGGATTGCTGGCAAAGCCCCCAAGAAGAAATCCCTGAGTGACCCCAGCCGCCGTGGGGAGCTGGCTGGGCCTGGATTCGAGG
GCCCTGGAGGGGAGCCCATCCGAGAAGTTGAGCCCATGCTGCCTCCATCCAGCAGCGAGCCCATCCTTGTAGAGCAGCGGGCAGAGCCAG
AAGAACCTGGTGCCACCAGGAGCCGGGCACAGTCTGAAAGGGCCCTACCTGAGGCTCTGCCTCCCCCTGCCACTGCCCACCGAAACTTTC
ACCTTGACCCCAAGCTGGCTGACATTCTGTCCCCGAGGCTAATCCGCCGAGGCTCCAAGAAGCGCCCAGCTCGGAGTAGTCACCAGGAGC
TTCGGAGAGACGAGGGCAGTCAGGACCAGACTGGCAGCCTGTCTCGGGCCCGGCCCTCCTCCAGACACGTTCGCCATGCCAGTGTGCCCG
CCACATTTATGCCTATTGTGGTGCCTGAGCCACCAACTTCTGTTGGTCCCCCTGTGGCTGTGCCAGAACCCATAGGCTTCCCTACCCGAG
CCCATCCCACGTTGCAGGCACCATCGCTCGAGGACGTCACCAAGCAGTACATGCTGAACCTGCACTCCGGTGAGGTCCCTGCCCCAGTGC
CAGTGGACATGCCCTGCTTGCCTCTGGCTGCACCGCCCTCTGCTGAGGCCAAGCCCCCTGAGGCAGCTCGGCCTGCAGATGAGCCTACCC
CTGCCAGCAAGTGCTGCAGCAAGCCACAGGTGCCTATGGGCTATGGGCCTCGTATGCAACAGCCTTCCAACCAGGGCCAGTTCCTTCCTC
AGACTCAGTTCCCATCACAGGGAATGAATGTAACAAATATCCCTTTGGCTCCGTCCAGCGGTCAAGCTCCAGTGTCTCAAGCACAAATGT
CTAGTTCTTCCTGCCCGGTGAACTCTCCTATAATGCCTCCAGGGTCTCAGGGGAGCCACATTCACTGTCCCCAGCTTCCTCAACCAGCTC
TTCATCAGAATTCACCCTCGCCTGTACCTAGTCGTACCCCCACCCCTCACCATACTCCCCCAAGCATAGGGGCTCAGCAGCCACCAGCAA
CAACAATTCCAGCCCCTGTTCCTACACCTCCTGCCATGCCACCTGGGCCACAGTCCCAGGCTCTACATCCCCCTCCAAGGCAGACACCTA
CACCACCAACAACACAACTTCCCCAACAAGTGCAGCCTTCACTTCCTGCTGCACCTTCTGCTGACCAGCCCCAGCAGCAGCCTCGCTCAC
AGCAGAGCACAGCAGCGTCTGTTCCTACCCCAACAGCACCGCTGCTTCCTCCGCAGCCTGCAACTCCACTTTCCCAGCCAGCTGTAAGCA
TTGAAGGACAGGTATCAAATCCTCCATCTACTAGTAGCACAGAAGTGAATTCTCAGGCCATTGCTGAGAAGCAGCCTTCCCAGGAAGTGA
AGATGGAGGCCAAAATGGAAGTGGATCAACCAGAACCAGCAGATACTCAGCCGGAGGATATTTCAGAGTCTAAAGTGGAAGACTGTAAAA
TGGAATCTACCGAAACAGAAGAGAGAAGCACTGAGTTAAAAACTGAAATAAAAGAGGAGGAAGACCAGCCAAGTACTTCAGCTACCCAGT
CATCTCCGGCTCCAGGACAGTCAAAGAAAAAGATTTTCAAACCAGAAGAACTACGACAGGCACTGATGCCAACTTTGGAGGCACTTTACC
GTCAGGATCCAGAATCCCTTCCCTTTCGTCAACCTGTGGACCCTCAGCTTTTAGGAATCCCTGATTACTTTGATATTGTGAAGAGCCCCA
TGGATCTTTCTACCATTAAGAGGAAGTTAGACACTGGACAGTATCAGGAGCCCTGGCAGTATGTCGATGATATTTGGCTTATGTTCAATA
ATGCCTGGTTATATAACCGGAAAACATCACGGGTATACAAATACTGCTCCAAGCTCTCTGAGGTCTTTGAACAAGAAATTGACCCAGTGA
TGCAAAGCCTTGGATACTGTTGTGGCAGAAAGTTGGAGTTCTCTCCACAGACACTGTGTTGCTACGGCAAACAGTTGTGCACAATACCTC
GTGATGCCACTTATTACAGTTACCAGAACAGGTATCATTTCTGTGAGAAGTGTTTCAATGAGATCCAAGGGGAGAGCGTTTCTTTGGGGG
ATGACCCTTCCCAGCCTCAAACTACAATAAATAAAGAACAATTTTCCAAGAGAAAAAATGACACACTGGATCCTGAACTGTTTGTTGAAT
GTACAGAGTGCGGAAGAAAGATGCATCAGATCTGTGTCCTTCACCATGAGATCATCTGGCCTGCTGGATTCGTCTGTGATGGCTGTTTAA
AGAAAAGTGCACGAACTAGGAAAGAAAATAAGTTTTCTGCTAAAAGGTTGCCATCTACCAGACTTGGCACCTTTCTAGAGAATCGTGTGA
ATGACTTTCTGAGGCGACAGAATCACCCTGAGTCAGGAGAGGTCACTGTTAGAGTAGTTCATGCTTCTGACAAAACCGTGGAAGTAAAAC
CAGGCATGAAAGCAAGGTTTGTGGACAGTGGAGAGATGGCAGAATCCTTTCCATACCGAACCAAAGCCCTCTTTGCCTTTGAAGAAATTG
ATGGTGTTGACCTGTGCTTCTTTGGCATGCATGTTCAAGAGTATGGCTCTGACTGCCCTCCACCCAACCAGAGGAGAGTATACATATCTT
ACCTCGATAGTGTTCATTTCTTCCGTCCTAAATGCTTGAGGACTGCAGTCTATCATGAAATCCTAATTGGATATTTAGAATATGTCAAGA
AATTAGGTTACACAACAGGGCATATTTGGGCATGTCCACCAAGTGAGGGAGATGATTATATCTTCCATTGCCATCCTCCTGACCAGAAGA
TACCCAAGCCCAAGCGACTGCAGGAATGGTACAAAAAAATGCTTGACAAGGCTGTATCAGAGCGTATTGTCCATGACTACAAGGATATTT
TTAAACAAGCTACTGAAGATAGATTAACAAGTGCAAAGGAATTGCCTTATTTCGAGGGTGATTTCTGGCCCAATGTTCTGGAAGAAAGCA
TTAAGGAACTGGAACAGGAGGAAGAAGAGAGAAAACGAGAGGAAAACACCAGCAATGAAAGCACAGATGTGACCAAGGGAGACAGCAAAA
ATGCTAAAAAGAAGAATAATAAGAAAACCAGCAAAAATAAGAGCAGCCTGAGTAGGGGCAACAAGAAGAAACCCGGGATGCCCAATGTAT
CTAACGACCTCTCACAGAAACTATATGCCACCATGGAGAAGCATAAAGAGGTCTTCTTTGTGATCCGCCTCATTGCTGGCCCTGCTGCCA
ACTCCCTGCCTCCCATTGTTGATCCTGATCCTCTCATCCCCTGCGATCTGATGGATGGTCGGGATGCGTTTCTCACGCTGGCAAGGGACA
AGCACCTGGAGTTCTCTTCACTCCGAAGAGCCCAGTGGTCCACCATGTGCATGCTGGTGGAGCTGCACACGCAGAGCCAGGACCGCTTTG
TCTACACCTGCAATGAATGCAAGCACCATGTGGAGACACGCTGGCACTGTACTGTCTGTGAGGATTATGACTTGTGTATCACCTGCTATA
ACACTAAAAACCATGACCACAAAATGGAGAAACTAGGCCTTGGCTTAGATGATGAGAGCAACAACCAGCAGGCTGCAGCCACCCAGAGCC
CAGGCGATTCTCGCCGCCTGAGTATCCAGCGCTGCATCCAGTCTCTGGTCCATGCTTGCCAGTGTCGGAATGCCAATTGCTCACTGCCAT
CCTGCCAGAAGATGAAGCGGGTTGTGCAGCATACCAAGGGTTGCAAACGGAAAACCAATGGCGGGTGCCCCATCTGCAAGCAGCTCATTG
CCCTCTGCTGCTACCATGCCAAGCACTGCCAGGAGAACAAATGCCCGGTGCCGTTCTGCCTAAACATCAAGCAGAAGCTCCGGCAGCAAC
AGCTGCAGCACCGACTACAGCAGGCCCAAATGCTTCGCAGGAGGATGGCCAGCATGCAGCGGACTGGTGTGGTTGGGCAGCAACAGGGCC
TCCCTTCCCCCACTCCTGCCACTCCAACGACACCAACTGGCCAACAGCCAACCACCCCGCAGACGCCCCAGCCCACTTCTCAGCCTCAGC
CTACCCCTCCCAATAGCATGCCACCCTACTTGCCCAGGACTCAAGCTGCTGGCCCTGTGTCCCAGGGTAAGGCAGCAGGCCAGGTGACCC
CTCCAACCCCTCCTCAGACTGCTCAGCCACCCCTTCCAGGGCCCCCACCTGCAGCAGTGGAAATGGCAATGCAGATTCAGAGAGCAGCGG
AGACGCAGCGCCAGATGGCCCACGTGCAAATTTTTCAAAGGCCAATCCAACACCAGATGCCCCCGATGACTCCCATGGCCCCCATGGGTA
TGAACCCACCTCCCATGACCAGAGGTCCCAGTGGGCATTTGGAGCCAGGGATGGGACCGACAGGGATGCAGCAACAGCCACCCTGGAGCC
AAGGAGGATTGCCTCAGCCCCAGCAACTACAGTCTGGGATGCCAAGGCCAGCCATGATGTCAGTGGCCCAGCATGGTCAACCTTTGAACA
TGGCTCCACAACCAGGATTGGGCCAGGTAGGTATCAGCCCACTCAAACCAGGCACTGTGTCTCAACAAGCCTTACAAAACCTTTTGCGGA
CTCTCAGGTCTCCCAGCTCTCCCCTGCAGCAGCAACAGGTGCTTAGTATCCTTCACGCCAACCCCCAGCTGTTGGCTGCATTCATCAAGC
AGCGGGCTGCCAAGTATGCCAACTCTAATCCACAACCCATCCCTGGGCAGCCTGGCATGCCCCAGGGGCAGCCAGGGCTACAGCCACCTA
CCATGCCAGGTCAGCAGGGGGTCCACTCCAATCCAGCCATGCAGAACATGAATCCAATGCAGGCGGGCGTTCAGAGGGCTGGCCTGCCCC
AGCAGCAACCACAGCAGCAACTCCAGCCACCCATGGGAGGGATGAGCCCCCAGGCTCAGCAGATGAACATGAACCACAACACCATGCCTT
CACAATTCCGAGACATCTTGAGACGACAGCAAATGATGCAACAGCAGCAGCAACAGGGAGCAGGGCCAGGAATAGGCCCTGGAATGGCCA
ACCATAACCAGTTCCAGCAACCCCAAGGAGTTGGCTACCCACCACAGCAGCAGCAGCGGATGCAGCATCACATGCAACAGATGCAACAAG
GAAATATGGGACAGATAGGCCAGCTTCCCCAGGCCTTGGGAGCAGAGGCAGGTGCCAGTCTACAGGCCTATCAGCAGCGACTCCTTCAGC
AACAGATGGGGTCCCCTGTTCAGCCCAACCCCATGAGCCCCCAGCAGCATATGCTCCCAAATCAGGCCCAGTCCCCACACCTACAAGGCC
AGCAGATCCCTAATTCTCTCTCCAATCAAGTGCGCTCTCCCCAGCCTGTCCCTTCTCCACGGCCACAGTCCCAGCCCCCCCACTCCAGTC
CTTCCCCAAGGATGCAGCCTCAGCCTTCTCCACACCACGTTTCCCCACAGACAAGTTCCCCACATCCTGGACTGGTAGCTGCCCAGGCCA
ACCCCATGGAACAAGGGCATTTTGCCAGCCCGGACCAGAATTCAATGCTTTCTCAGCTTGCTAGCAATCCAGGCATGGCAAACCTCCATG
GTGCAAGCGCCACGGACCTGGGACTCAGCACCGATAACTCAGACTTGAATTCAAACCTCTCACAGAGTACACTAGACATACACTAGAGAC
ACCTTGTAGTATTTTGGGAGCAAAAAAATTATTTTCTCTTAACAAGACTTTTTGTACTGAAAACAATTTTTTTGAATCTTTCGTAGCCTA
AAAGACAATTTTCCTTGGAACACATAAGAACTGTGCAGTAGCCGTTTGTGGTTTAAAGCAAACATGCAAGATGAACCTGAGGGATGATAG
AATACAAAGAATATATTTTTGTTATGGCTGGTTACCACCAGCCTTTCTTCCCCTTTGTGTGTGTGGTTCAAGTGTGCACTGGGAGGAGGC
TGAGGCCTGTGAAGCCAAACAATATGCTCCTGCCTTGCACCTCCAATAGGTTTTATTATTTTTTTTAAATTAATGAACATATGTAATATT
AATAGTTATTATTTACTGGTGCAGATGGTTGACATTTTTCCCTATTTTCCTCACTTTATGGAAGAGTTAAAACATTTCTAAACCAGAGGA
CAAAAGGGGTTAATGTTACTTTAAAATTACATTCTATATATATATAAATATATATAAATATATATTAAAATACCAGTTTTTTTTCTCTGG
GTGCAAAGATGTTCATTCTTTTAAAAAATGTTTAAAAAAAAAAAAAAACTGCCTTTCTTCCCCTCAAGTCAACTTTTGTGCTCCAGAAAA
TTTTCTATTCTGTAAGTCTGAGCGTAAAACTTCAAGTATTAAAATAATTTGTACATGTAGAGAGAAAAATGACTTTTTCAAAAATATACA
GGGGCAGCTGCCAAATTGATGTATTATATATTGTGGTTTCTGTTTCTTGAAAGAATTTTTTTCGTTATTTTTACATCTAACAAAGTAAAA
AAATTAAAAAGAGGGTAAGAAACGATTCCGGTGGGATGATTTTAACATGCAAAATGTCCCTGGGGGTTTCTTCTTTGCTTGCTTTCTTCC
TCCTTACCCTACCCCCCACTCACACACACACACACACACACACACACACACACACACACACACTTTCTATAAAACTTGAAAATAGCAAAA
ACCCTCAACTGTTGTAAATCATGCAATTAAAGTTGATTACTTATAAATATGAACTTTGGATCACTGTATAGACTGTTAAATTTGATTTCT

>6228_6228_2_ARHGEF17-EP300_ARHGEF17_chr11_73022875_ENST00000263674_EP300_chr22_41545042_ENST00000263253_length(amino acids)=2778AA_BP=1111
MLRSLRPLPTLPCAAFGVGRCAPREWGRRGGWPRLPEASPPGVSYATMADGAPRPQLYRSVSFKLLERWSGGPGLREEDTDTPGLRRRAS
CRPTTAARGQPSRRVSKLASGPLAAPAQPRPLRSLSPSVRQLSRRFDAPRLDDGSAGTRDGGVLPAAAEEAAEGPARGAWPSVTEMRKLF
GGPGSRRPSADSESPGTPSPDGAAWEPPARESRQPPTPPPRTCFPLAGLRSARPLTGPETEGRLRRPQQQQERAQRPADGLHSWHIFSQP
QAGARASCSSSSIAASYPVSRSRAASSSEEEEEGPPQLPGAQSPAYHGGHSSGSDDDRDGEGGHRWGGRPGLRPGSSLLDQDCRPDSDGL
NLSSMNSAGVSGSPEPPTSPRAPREEGLREWGSGSPPCVPGPQEGLRPMSDSVGGAFRVAKVSFPSYLASPAGSRGSSRYSSTETLKDDD
LWSSRGSGGWGVYRSPSFGAGEGLLRSQARTRAKGPGGTSRALRDGGFEPEKSRQRKSLSNPDIASETLTLLSFLRSDLSELRVRKPGGS
SGDRGSNPLDGRDSPSAGGPVGQLEPIPIPAPASPGTRPTLKDLTATLRRAKSFTCSEKPMARRLPRTSALKSSSSELLLTGPGAEEDPL
PLIVQDQYVQEARQVFEKIQRMGAQQDDGSDAPPGSPDWAGDVTRGQRSQEELSGPESSLTDEGIGADPEPPVAAFCGLGTTGMWRPLSS
SSAQTNHHGPGTEDSLGGWALVSPETPPTPGALRRRRKVPPSGSGGSELSNGEAGEAYRSLSDPIPQRHRAATSEEPTGFSVDSNLLGSL
SPKTGLPATSAMDEGLTSGHSDWSVGSEESKGYQEVIQSIVQGPGTLGRVVDDRIAGKAPKKKSLSDPSRRGELAGPGFEGPGGEPIREV
EPMLPPSSSEPILVEQRAEPEEPGATRSRAQSERALPEALPPPATAHRNFHLDPKLADILSPRLIRRGSKKRPARSSHQELRRDEGSQDQ
TGSLSRARPSSRHVRHASVPATFMPIVVPEPPTSVGPPVAVPEPIGFPTRAHPTLQAPSLEDVTKQYMLNLHSGEVPAPVPVDMPCLPLA
APPSAEAKPPEAARPADEPTPASKCCSKPQVPMGYGPRMQQPSNQGQFLPQTQFPSQGMNVTNIPLAPSSGQAPVSQAQMSSSSCPVNSP
IMPPGSQGSHIHCPQLPQPALHQNSPSPVPSRTPTPHHTPPSIGAQQPPATTIPAPVPTPPAMPPGPQSQALHPPPRQTPTPPTTQLPQQ
VQPSLPAAPSADQPQQQPRSQQSTAASVPTPTAPLLPPQPATPLSQPAVSIEGQVSNPPSTSSTEVNSQAIAEKQPSQEVKMEAKMEVDQ
PEPADTQPEDISESKVEDCKMESTETEERSTELKTEIKEEEDQPSTSATQSSPAPGQSKKKIFKPEELRQALMPTLEALYRQDPESLPFR
QPVDPQLLGIPDYFDIVKSPMDLSTIKRKLDTGQYQEPWQYVDDIWLMFNNAWLYNRKTSRVYKYCSKLSEVFEQEIDPVMQSLGYCCGR
KLEFSPQTLCCYGKQLCTIPRDATYYSYQNRYHFCEKCFNEIQGESVSLGDDPSQPQTTINKEQFSKRKNDTLDPELFVECTECGRKMHQ
ICVLHHEIIWPAGFVCDGCLKKSARTRKENKFSAKRLPSTRLGTFLENRVNDFLRRQNHPESGEVTVRVVHASDKTVEVKPGMKARFVDS
GEMAESFPYRTKALFAFEEIDGVDLCFFGMHVQEYGSDCPPPNQRRVYISYLDSVHFFRPKCLRTAVYHEILIGYLEYVKKLGYTTGHIW
ACPPSEGDDYIFHCHPPDQKIPKPKRLQEWYKKMLDKAVSERIVHDYKDIFKQATEDRLTSAKELPYFEGDFWPNVLEESIKELEQEEEE
RKREENTSNESTDVTKGDSKNAKKKNNKKTSKNKSSLSRGNKKKPGMPNVSNDLSQKLYATMEKHKEVFFVIRLIAGPAANSLPPIVDPD
PLIPCDLMDGRDAFLTLARDKHLEFSSLRRAQWSTMCMLVELHTQSQDRFVYTCNECKHHVETRWHCTVCEDYDLCITCYNTKNHDHKME
KLGLGLDDESNNQQAAATQSPGDSRRLSIQRCIQSLVHACQCRNANCSLPSCQKMKRVVQHTKGCKRKTNGGCPICKQLIALCCYHAKHC
QENKCPVPFCLNIKQKLRQQQLQHRLQQAQMLRRRMASMQRTGVVGQQQGLPSPTPATPTTPTGQQPTTPQTPQPTSQPQPTPPNSMPPY
LPRTQAAGPVSQGKAAGQVTPPTPPQTAQPPLPGPPPAAVEMAMQIQRAAETQRQMAHVQIFQRPIQHQMPPMTPMAPMGMNPPPMTRGP
SGHLEPGMGPTGMQQQPPWSQGGLPQPQQLQSGMPRPAMMSVAQHGQPLNMAPQPGLGQVGISPLKPGTVSQQALQNLLRTLRSPSSPLQ
QQQVLSILHANPQLLAAFIKQRAAKYANSNPQPIPGQPGMPQGQPGLQPPTMPGQQGVHSNPAMQNMNPMQAGVQRAGLPQQQPQQQLQP
PMGGMSPQAQQMNMNHNTMPSQFRDILRRQQMMQQQQQQGAGPGIGPGMANHNQFQQPQGVGYPPQQQQRMQHHMQQMQQGNMGQIGQLP
QALGAEAGASLQAYQQRLLQQQMGSPVQPNPMSPQQHMLPNQAQSPHLQGQQIPNSLSNQVRSPQPVPSPRPQSQPPHSSPSPRMQPQPS

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Fusion Gene PPI Analysis for ARHGEF17-EP300


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with
TgeneEP300chr11:73022875chr22:41545041ENST0000026325311311397_1399747.02415.0histone
TgeneEP300chr11:73022875chr22:41545042ENST0000026325311311397_1399747.02415.0histone
TgeneEP300chr11:73022875chr22:41545041ENST0000026325311312003_2212747.02415.0HTLV-1 Tax
TgeneEP300chr11:73022875chr22:41545042ENST0000026325311312003_2212747.02415.0HTLV-1 Tax
TgeneEP300chr11:73022875chr22:41545041ENST0000026325311312041_2240747.02415.0NCOA2
TgeneEP300chr11:73022875chr22:41545042ENST0000026325311312041_2240747.02415.0NCOA2


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneEP300chr11:73022875chr22:41545041ENST0000026325311312_139747.02415.0ALX1
TgeneEP300chr11:73022875chr22:41545042ENST0000026325311312_139747.02415.0ALX1
TgeneEP300chr11:73022875chr22:41545041ENST0000026325311312_149747.02415.0RORA
TgeneEP300chr11:73022875chr22:41545042ENST0000026325311312_149747.02415.0RORA


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGEF17-EP300


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGEF17-EP300


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneC0279626Squamous cell carcinoma of esophagus2CTD_human
TgeneC0001973Alcoholic Intoxication, Chronic1PSYGENET
TgeneC0005684Malignant neoplasm of urinary bladder1CTD_human
TgeneC0005695Bladder Neoplasm1CTD_human
TgeneC0006142Malignant neoplasm of breast1CGI;CTD_human;UNIPROT
TgeneC0007137Squamous cell carcinoma1CTD_human
TgeneC0007138Carcinoma, Transitional Cell1CTD_human
TgeneC0010606Adenoid Cystic Carcinoma1CTD_human
TgeneC0014170Endometrial Neoplasms1CTD_human
TgeneC0014518Toxic Epidermal Necrolysis1CTD_human
TgeneC0025202melanoma1CTD_human
TgeneC0028754Obesity1CTD_human
TgeneC0038325Stevens-Johnson Syndrome1CTD_human
TgeneC0079772T-Cell Lymphoma1CTD_human
TgeneC0149925Small cell carcinoma of lung1CTD_human
TgeneC0152013Adenocarcinoma of lung (disorder)1CTD_human
TgeneC0376634Craniofacial Abnormalities1CTD_human
TgeneC0476089Endometrial Carcinoma1CTD_human
TgeneC0678222Breast Carcinoma1CGI;CTD_human
TgeneC1257931Mammary Neoplasms, Human1CTD_human
TgeneC1274933Drug-Induced Stevens Johnson Syndrome1CTD_human
TgeneC1458155Mammary Neoplasms1CTD_human
TgeneC3150941RUBINSTEIN-TAYBI SYNDROME 21GENOMICS_ENGLAND
TgeneC3658301Mycoplasma-Induced Stevens-Johnson Syndrome1CTD_human
TgeneC3658302Stevens-Johnson Syndrome Toxic Epidermal Necrolysis Spectrum1CTD_human
TgeneC4704874Mammary Carcinoma, Human1CTD_human