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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Diseases

Fusion gene:FCHSD2-ARHGEF17 (FusionGDB2 ID:HG9873TG9828)

Fusion Gene Summary for FCHSD2-ARHGEF17

check button Fusion gene summary
Fusion gene informationFusion gene name: FCHSD2-ARHGEF17
Fusion gene ID: hg9873tg9828
HgeneTgene
Gene symbol

FCHSD2

ARHGEF17

Gene ID

9873

9828

Gene nameFCH and double SH3 domains 2Rho guanine nucleotide exchange factor 17
SynonymsNWK|NWK1|SH3MD3P164RHOGEF|RHOGEF17|TEM4|p164-RhoGEF
Cytomap('FCHSD2')('ARHGEF17')

11q13.4

11q13.4

Type of geneprotein-codingprotein-coding
DescriptionF-BAR and double SH3 domains protein 2FCH and double SH3 domains protein 2SH3 multiple domains 3SH3 multiple domains protein 3caromnervous wreck homologprotein nervous wreck 1rho guanine nucleotide exchange factor 17164 kDa Rho-specific guanine-nucleotide exchange factorRho guanine nucleotide exchange factor (GEF) 17Rho-specific guanine-nucleotide exchange factor 164 kDatumor endothelial marker 4
Modification date2020031320200313
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000311172, ENST00000409314, 
ENST00000409418, ENST00000409853, 
ENST00000458644, ENST00000409263, 
Fusion gene scores* DoF score43 X 26 X 16=178885 X 3 X 5=75
# samples 595
** MAII scorelog2(59/17888*10)=-4.92213332859399
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: FCHSD2 [Title/Abstract] AND ARHGEF17 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointFCHSD2(72578910)-ARHGEF17(73057928), # samples:3
Anticipated loss of major functional domain due to fusion event.FCHSD2-ARHGEF17 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FCHSD2-ARHGEF17 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FCHSD2-ARHGEF17 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FCHSD2-ARHGEF17 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FCHSD2-ARHGEF17 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FCHSD2-ARHGEF17 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneARHGEF17

GO:0030036

actin cytoskeleton organization

12071859


check buttonFusion gene breakpoints across FCHSD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ARHGEF17 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-BG-A3PP-01AFCHSD2chr11

72578910

-ARHGEF17chr11

73057928

+


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Fusion Gene ORF analysis for FCHSD2-ARHGEF17

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-3UTRENST00000311172ENST00000536170FCHSD2chr11

72578910

-ARHGEF17chr11

73057928

+
5CDS-3UTRENST00000409314ENST00000536170FCHSD2chr11

72578910

-ARHGEF17chr11

73057928

+
5CDS-3UTRENST00000409418ENST00000536170FCHSD2chr11

72578910

-ARHGEF17chr11

73057928

+
5CDS-3UTRENST00000409853ENST00000536170FCHSD2chr11

72578910

-ARHGEF17chr11

73057928

+
5CDS-3UTRENST00000458644ENST00000536170FCHSD2chr11

72578910

-ARHGEF17chr11

73057928

+
Frame-shiftENST00000409853ENST00000263674FCHSD2chr11

72578910

-ARHGEF17chr11

73057928

+
In-frameENST00000311172ENST00000263674FCHSD2chr11

72578910

-ARHGEF17chr11

73057928

+
In-frameENST00000409314ENST00000263674FCHSD2chr11

72578910

-ARHGEF17chr11

73057928

+
In-frameENST00000409418ENST00000263674FCHSD2chr11

72578910

-ARHGEF17chr11

73057928

+
In-frameENST00000458644ENST00000263674FCHSD2chr11

72578910

-ARHGEF17chr11

73057928

+
intron-3CDSENST00000409263ENST00000263674FCHSD2chr11

72578910

-ARHGEF17chr11

73057928

+
intron-3UTRENST00000409263ENST00000536170FCHSD2chr11

72578910

-ARHGEF17chr11

73057928

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000311172FCHSD2chr1172578910-ENST00000263674ARHGEF17chr1173057928+5690137912543781417
ENST00000409314FCHSD2chr1172578910-ENST00000263674ARHGEF17chr1173057928+5860154916945481459
ENST00000409418FCHSD2chr1172578910-ENST00000263674ARHGEF17chr1173057928+6003169238446911435
ENST00000458644FCHSD2chr1172578910-ENST00000263674ARHGEF17chr1173057928+5582127129042701326

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000311172ENST00000263674FCHSD2chr1172578910-ARHGEF17chr1173057928+0.0030912650.9969087
ENST00000409314ENST00000263674FCHSD2chr1172578910-ARHGEF17chr1173057928+0.0029351250.9970649
ENST00000409418ENST00000263674FCHSD2chr1172578910-ARHGEF17chr1173057928+0.0039000520.99609995
ENST00000458644ENST00000263674FCHSD2chr1172578910-ARHGEF17chr1173057928+0.0040016380.9959984

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Fusion Genomic Features for FCHSD2-ARHGEF17


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
FCHSD2chr1172578909-ARHGEF17chr1173057927+7.55E-091
FCHSD2chr1172578909-ARHGEF17chr1173057927+7.55E-091

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for FCHSD2-ARHGEF17


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:72578910/chr11:73057928)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFCHSD2chr11:72578910chr11:73057928ENST00000409418-1320356_397436741.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72578910chr11:73057928ENST00000311172-12198_282380685.0DomainF-BAR
HgeneFCHSD2chr11:72578910chr11:73057928ENST00000409418-13208_282436741.0DomainF-BAR
HgeneFCHSD2chr11:72578910chr11:73057928ENST00000409853-13168_282380516.0DomainF-BAR
TgeneARHGEF17chr11:72578910chr11:73057928ENST000002636740211990_199610642064.0Compositional biasNote=Poly-Pro
TgeneARHGEF17chr11:72578910chr11:73057928ENST000002636740211066_125410642064.0DomainDH

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFCHSD2chr11:72578910chr11:73057928ENST00000311172-1219356_397380685.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72578910chr11:73057928ENST00000409853-1316356_397380516.0Coiled coilOntology_term=ECO:0000255
HgeneFCHSD2chr11:72578910chr11:73057928ENST00000311172-1219718_721380685.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72578910chr11:73057928ENST00000409418-1320718_721436741.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72578910chr11:73057928ENST00000409853-1316718_721380516.0Compositional biasNote=Poly-Pro
HgeneFCHSD2chr11:72578910chr11:73057928ENST00000311172-1219469_530380685.0DomainSH3 1
HgeneFCHSD2chr11:72578910chr11:73057928ENST00000409418-1320469_530436741.0DomainSH3 1
HgeneFCHSD2chr11:72578910chr11:73057928ENST00000409853-1316469_530380516.0DomainSH3 1
HgeneFCHSD2chr11:72578910chr11:73057928ENST00000311172-1219567_629380685.0RegionRequired and sufficient for location at clathrin-coated pits
HgeneFCHSD2chr11:72578910chr11:73057928ENST00000409418-1320567_629436741.0RegionRequired and sufficient for location at clathrin-coated pits
HgeneFCHSD2chr11:72578910chr11:73057928ENST00000409853-1316567_629380516.0RegionRequired and sufficient for location at clathrin-coated pits
TgeneARHGEF17chr11:72578910chr11:73057928ENST00000263674021201_20410642064.0Compositional biasNote=Poly-Gln
TgeneARHGEF17chr11:72578910chr11:73057928ENST00000263674021230_23510642064.0Compositional biasNote=Poly-Ser
TgeneARHGEF17chr11:72578910chr11:73057928ENST00000263674021252_25610642064.0Compositional biasNote=Poly-Glu
TgeneARHGEF17chr11:72578910chr11:73057928ENST00000263674021566_56910642064.0Compositional biasNote=Poly-Ser
TgeneARHGEF17chr11:72578910chr11:73057928ENST00000263674021672_67510642064.0Compositional biasNote=Poly-Ser
TgeneARHGEF17chr11:72578910chr11:73057928ENST00000263674021707_71010642064.0Compositional biasNote=Poly-Arg
TgeneARHGEF17chr11:72578910chr11:73057928ENST00000263674021963_105410642064.0Compositional biasNote=Pro-rich


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Fusion Gene Sequence for FCHSD2-ARHGEF17


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>29981_29981_1_FCHSD2-ARHGEF17_FCHSD2_chr11_72578910_ENST00000311172_ARHGEF17_chr11_73057928_ENST00000263674_length(transcript)=5690nt_BP=1379nt
GTCCGCCTGCCGCCCGCTGGCCTGCTCCCTCCGGGGCAAGTCTTGCTTCTTAAGCGCTCCTTTCACACACGCGCGCGCTCGCTGGGCCGT
CCCCTCCTCTCCGGCCCTCCTCCTCCTCCTGGTCCTTGCTAACGCTGCCGTCGGGGAGGATTGATGTCCCTTCAGCATCATGCAGCCGCC
GCCGAGGAAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAGTATGCACAGGGTATGCAGAAGTTGGCTAGTCAATACCTGAAGA
GAGATTGGCCTGGAGTAAAAGCTGATGATCGGAATGATTACAGGAGCATGTATCCCGTTTGGAAATCTTTTCTCGAGGGAACAATGCAGG
TAGCCCAGTCTCGGATGAATATATGTGAAAACTATAAAAACTTCATTTCTGAGCCTGCAAGGACAGTGAGAAGCTTAAAAGAACAGCAAC
TAAAAAGGTGTGTGGACCAGTTGACAAAGATCCAAACTGAATTACAAGAGACAGTGAAAGATTTAGCTAAAGGCAAAAAGAAATACTTTG
AGACTGAACAGATGGCTCATGCAGTACGAGAGAAAGCTGACATCGAGGCAAAATCTAAACTTAGTCTTTTTCAATCAAGAATCAGTTTAC
AGAAGGCAAGTGTAAAGTTAAAAGCCCGGCGATCTGAGTGTAATTCCAAAGCTACCCACGCAAGGAATGATTATCTTCTTACCCTAGCGG
CAGCAAATGCACATCAGGATCGCTACTATCAAACAGATTTAGTTAACATTATGAAGGCTCTTGATGGAAATGTGTATGATCATCTCAAGG
ATTATTTAATAGCCTTCAGCCGGACTGAGCTAGAAACATGCCAAGCTGTGCAGAACACATTCCAGTTTTTATTAGAAAACTCCAGCAAGG
TGGTCCGGGACTACAATCTTCAGCTGTTTTTGCAAGAAAACGCTGTATTTCACAAACCCCAGCCCTTCCAGTTCCAGCCTTGTGACAGTG
ATACTAGCCGACAGTTAGAATCAGAAACTGGGACCACAGAGGAGCACAGTCTAAATAAGGAAGCTCGAAAATGGGCCACACGTGTGGCAC
GTGAGCATAAAAACATTGTTCACCAACAACGGGTTCTAAATGATCTGGAGTGTCATGGAGCTGCTGTATCAGAACAAAGCCGAGCAGAGC
TAGAACAGAAAATAGATGAAGCTAGAGAAAATATTCGTAAAGCAGAGATAATTAAATTGAAAGCTGAAGCCCGGTTGGACCTGCTAAAGC
AGATTGGTGTTTCTGTGGACACATGGCTAAAGAGTGCCATGAACCAAGTAATGGAAGAACTGGAAAATGAGCGATGGGCCCGCCCTCCTG
CAGTGACCAGTAATGGCACTTTACACTCGGACATGCGGAAGCACGTGGCCATGACCCTGCTGGACACAGAGCAGTCGTATGTGGAGTCGC
TGCGCACCCTGATGCAGGGCTACATGCAGCCGCTGAAGCAGCCAGAGAACTCCGTGCTCTGTGACCCTTCACTGGTGGACGAGATCTTCG
ACCAGATCCCCGAGCTCCTGGAGCACCACGAGCAATTCCTGGAGCAGGTTCGGCACTGCATGCAGACCTGGCATGCCCAGCAGAAGGTGG
GAGCCCTGCTCGTCCAGTCGTTCTCCAAGGATGTCCTAGTAAACATCTATTCTGCCTATATCGATAACTTCCTCAATGCAAAGGATGCTG
TGCGTGTGGCCAAGGAGGCGAGGCCTGCCTTTCTCAAGTTCCTAGAGCAAAGCATGCGTGAGAACAAGGAGAAGCAGGCGCTGTCTGACC
TCATGATCAAGCCTGTGCAGCGGATCCCACGCTACGAGCTTCTGGTGAAGGACCTCCTGAAGCATACACCTGAGGACCACCCGGACCATC
CACTCCTGCTGGAGGCGCAGCGGAACATCAAGCAGGTGGCTGAGCGCATCAACAAGGGTGTGCGGAGTGCCGAGGAGGCGGAGCGCCATG
CCCGTGTGCTGCAGGAGATAGAGGCTCACATCGAGGGCATGGAGGATCTCCAGGCCCCTCTGCGGCGGTTCCTGAGACAGGAGATGGTCA
TTGAAGTGAAGGCGATCGGTGGCAAGAAGGACCGGTCTCTCTTCCTGTTCACGGACCTCATCGTCTGCACCACTCTGAAGCGAAAGTCAG
GCTCCCTGCGGCGCAGCTCCATGAGCCTGTACACGGCAGCCAGTGTCATTGACACAGCCAGCAAGTACAAGATGCTGTGGAAGCTGCCGC
TGGAAGACGCAGACATCATCAAAGGGGCATCCCAAGCCACCAATCGGGAGAACATCCAGAAGGCCATCAGCCGCCTTGATGAGGACCTCA
CCACCCTGGGCCAAATGAGCAAGCTCTCTGAGAGCCTTGGTTTCCCCCACCAGAGCCTGGACGATGCACTGCGGGACCTCTCAGCTGCCA
TGCACCGGGACCTGTCGGAGAAGCAGGCGCTGTGCTACGCGCTTTCCTTCCCGCCAACCAAGCTGGAGCTGTGCGCCACTCGGCCCGAGG
GCACCGACTCCTACATTTTTGAGTTCCCTCACCCTGACGCCCGCCTTGGTTTTGAACAGGCCTTCGATGAGGCCAAGAGGAAGCTGGCAT
CCAGCAAAAGCTGTCTAGACCCTGAGTTCCTGAAGGCCATCCCCATCATGAAAACCCGCAGTGGCATGCAGTTCTCCTGTGCGGCTCCCA
CCCTGAACAGCTGCCCGGAGCCCTCGCCTGAGGTATGGGTCTGCAACAGCGACGGCTACGTGGGCCAGGTGTGCCTGCTGAGCCTGCGCG
CCGAGCCGGACGTGGAGGCCTGCATCGCCGTCTGTTCCGCCCGCATCCTCTGCATCGGGGCGGTGCCCGGGCTGCAGCCTCGCTGCCACC
GGGAGCCTCCTCCGTCGCTGAGGAGTCCTCCAGAGACGGCACCGGAGCCCGCCGGGCCGGAGCTGGACGTCGAGGCCGCTGCAGACGAGG
AAGCCGCGACGCTCGCGGAGCCGGGGCCGCAGCCCTGCCTTCACATCTCCATTGCAGGCTCGGGCTTGGAGATGACGCCGGGCCTCGGCG
AGGGTGACCCCCGCCCAGAGCTGGTGCCCTTTGACAGTGACTCTGACGATGAGTCTTCGCCCAGCCCCTCGGGGACGCTGCAGAGCCAGG
CCAGCCGGTCCACCATCTCCTCCAGCTTTGGCAATGAGGAGACCCCGAGTTCCAAGGAGGCCACGGCAGAGACCACCAGCTCAGAGGAGG
AGCAGGAGCCAGGCTTCCTGCCACTGTCTGGCTCCTTTGGGCCTGGTGGTCCCTGCGGCACCAGCCCAATGGATGGGAGAGCCCTTCGCC
GCTCCAGCCACGGCTCCTTCACCCGGGGCAGCCTTGAGGACCTGCTGAGTGTCGACCCTGAGGCCTACCAGAGCTCCGTGTGGCTGGGCA
CTGAGGATGGCTGTGTCCACGTGTACCAGTCCTCCGACAGCATCCGTGACCGCAGGAACAGCATGAAGCTCCAGCATGCGGCCTCTGTGA
CCTGCATCTTGTATCTGAATAACCAGGTGTTTGTGTCTCTGGCCAATGGAGAGCTTGTGGTCTACCAAAGGGAAGCAGGCCATTTCTGGG
ACCCCCAGAACTTCAAATCAGTGACCTTGGGCACCCAGGGGAGCCCCATCACCAAGATGGTATCTGTGGGTGGGCGGCTGTGGTGTGGCT
GCCAGAACCGAGTCCTTGTCCTGAGCCCTGACACGCTGCAGCTGGAGCACATGTTTTACGTGGGTCAGGATTCAAGCCGCTGCGTGGCTT
GCATGGTGGACTCCAGCCTGGGTGTGTGGGTGACATTGAAAGGTAGTGCCCACGTGTGTCTCTACCATCCAGACACCTTTGAGCAGCTGG
CAGAAGTAGACGTCACTCCTCCCGTGCACAGGATGCTGGCAGGCTCGGATGCCATCATCCGGCAGCACAAGGCTGCCTGTCTGCGAATCA
CAGCGCTGCTGGTGTGTGAGGAGCTGCTGTGGGTGGGCACCAGTGCTGGTGTCGTCCTCACCATGCCCACTTCGCCCGGTACTGTCAGCT
GCCCACGGGCACCACTCAGTCCCACAGGCCTCGGCCAGGGACACACCGGCCACGTCCGCTTCTTGGCTGCAGTCCAGCTGCCAGATGGCT
TCAACCTGCTCTGCCCAACCCCACCACCTCCCCCAGACACAGGCCCCGAGAAGCTGCCATCACTGGAGCACCGGGACTCCCCTTGGCACC
GAGGCCCCGCCCCTGCCAGGCCTAAAATGCTGGTTATCAGTGGAGGTGATGGCTATGAGGACTTCCGACTCAGCAGTGGGGGCGGCAGCA
GCAGTGAGACTGTGGGTCGAGACGACAGCACAAACCACCTCCTCCTGTGGAGGGTGTGACCCTGTCTGCCGTGGCCCAGGACTCGCCCGC
CCACCTGCCTTCAGCCTGCTTGCCTCTCCCTAGCCCACACGCAGACTTTGACCAGGAGTATCCAGCCAGGGGCACACATGTGCCTGCGTG
GGCTCTGCCTTGTCTTCGCGGAAGCATTCCTGATGGAACACCCACTGGCCAGCCAGGCCATGGCTTCTCCCGACCCTCTGGCTGCCCCGG
TGCTTCCAGTCATGATCGGGTGGGGGACATGTGGGCTGACCAGGACCTCTGACCCTGGAGCTTCTACCAAAGACACAGCTGGGTCTGGAC
CCCACGGGGCTGGGGAGGGCCATGTGCAATATTTGGAGGGTTTTCTGGAGGGCAGCAGGAAGGCTGGGGAATTCCCCATGTACAGTATTT
ATGTTTCTTTTTAGATGTGTACCTTCCCAAGCACTTATTTATGCAGTGACCTGGTCACCTGGGGTGGGGGTGATTTGAGGAAATGACATG
AGGAAAAGAAACCTATTCCTGCCCTGGGGACCACCCTGGGACTCTAACCAAGCCTTCCTGGAGGGACCCATGCGCCCCTGAGCCCCATTC
CATTCATACAGACACACACGTACGCACACTGCATGTCCAAGGCCCTAAACATTGCCCGTTGACATAAACTTTCCAGGGCCCCAGCCTGAT
GGGGCTGCCCTCAGTCCTCTAGATCAAGATGCTGACTATTAGGGGGCAGTGATTGCCATCTGGGGACCTGTCAGGCTTTGTCATTTCCCA
GTTTGTTGGTGGTGCCTTTAGTGGTTCCCTAATTTGGGAACACTGATGGGGCCTTGGACAGGGCTTTCTCTCAGGTAGGAGAAATGGGCC
CATGATCTCCTCACAGTCGCCCCCAGTCCTTGGCCCTGCTTCCCTGTGTCTCATGCACTGGCACATATGGTCACCTTGGAGGGCAGACCT
AGGAGCCCCTCTGACCACTGAATCCGTCTCCACACCCCTTCTGCCAAGGGAAGCCCCTTCAGGAAGGACCCCCCAAAGCTGAGGGGCTGA
ATGTAGCCTTTTCAACAGAGAAGGCTCCCACTTGAGAGCAGCCTCTACCTGACCCCCTGGACCACAGAGAGCCACTCTGACCCTCAGCCC
CCTCGCTTCTTCAGCTAAAACTCCAAAGGTTTGGTTTCAGATGGGGTTTGTTTTGTTCTGTTTGGTTTTGGTTTTGTTTGGGGTGGGTGG
GTCATTGCGGTCTTAGATTATGTTTCTCTTGCTACCAAACAGTCATGTATTAACTCTCTTTGGATGATGAAGTTTAAAGAGTCAATAAAT

>29981_29981_1_FCHSD2-ARHGEF17_FCHSD2_chr11_72578910_ENST00000311172_ARHGEF17_chr11_73057928_ENST00000263674_length(amino acids)=1417AA_BP=413
MLTLPSGRIDVPSASCSRRRGRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSFLEGTMQVAQSRMNICENY
KNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRS
ECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQ
ENAVFHKPQPFQFQPCDSDTSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLECHGAAVSEQSRAELEQKIDEARENI
RKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENERWARPPAVTSNGTLHSDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPL
KQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFL
KFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIE
GMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQ
ATNRENIQKAISRLDEDLTTLGQMSKLSESLGFPHQSLDDALRDLSAAMHRDLSEKQALCYALSFPPTKLELCATRPEGTDSYIFEFPHP
DARLGFEQAFDEAKRKLASSKSCLDPEFLKAIPIMKTRSGMQFSCAAPTLNSCPEPSPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVC
SARILCIGAVPGLQPRCHREPPPSLRSPPETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLEMTPGLGEGDPRPELVPFD
SDSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSKEATAETTSSEEEQEPGFLPLSGSFGPGGPCGTSPMDGRALRRSSHGSFTRGSL
EDLLSVDPEAYQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREAGHFWDPQNFKSVTLGT
QGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRM
LAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLGQGHTGHVRFLAAVQLPDGFNLLCPTPPPPP

--------------------------------------------------------------
>29981_29981_2_FCHSD2-ARHGEF17_FCHSD2_chr11_72578910_ENST00000409314_ARHGEF17_chr11_73057928_ENST00000263674_length(transcript)=5860nt_BP=1549nt
GTCCGCCTGCCGCCCGCTGGCCTGCTCCCTCCGGGGCAAGTCTTGCTTCTTAAGCGCTCCTTTCACACACGCGCGCGCTCGCTGGGCCGT
CCCCTCCTCTCCGGCCCTCCTCCTCCTCCTGGTCCTTGCTAACGCTGCCGTCGGGGAGGATTGATGTCCCTTCAGCATCATGCAGCCGCC
GCCGAGGAAGGTGAAAGTTACACAAGAACTGAAAAACATTCAAGTTGAGCAGATGACAAAACTTCAAGCCAAACATCAAGCAGAATGTGA
TTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAGTATGCACAGGGTATGCAGAAGTTGGCTAGTCAATA
CCTGAAGAGAGATTGGCCTGGAGTAAAAGCTGATGATCGGAATGATTACAGGAGCATGTATCCCGTTTGGAAATCTTTTCTCGAGGGAAC
AATGCAGGTAGCCCAGTCTCGGATGAATATATGTGAAAACTATAAAAACTTCATTTCTGAGCCTGCAAGGACAGTGAGAAGCTTAAAAGA
ACAGCAACTAAAAAGGTGTGTGGACCAGTTGACAAAGATCCAAACTGAATTACAAGAGACAGTGAAAGATTTAGCTAAAGGCAAAAAGAA
ATACTTTGAGACTGAACAGATGGCTCATGCAGTACGAGAGAAAGCTGACATCGAGGCAAAATCTAAACTTAGTCTTTTTCAATCAAGAAT
CAGTTTACAGAAGGCAAGTGTAAAGTTAAAAGCCCGGCGATCTGAGTGTAATTCCAAAGCTACCCACGCAAGGAATGATTATCTTCTTAC
CCTAGCGGCAGCAAATGCACATCAGGATCGCTACTATCAAACAGATTTAGTTAACATTATGAAGGCTCTTGATGGAAATGTGTATGATCA
TCTCAAGGATTATTTAATAGCCTTCAGCCGGACTGAGCTAGAAACATGCCAAGCTGTGCAGAACACATTCCAGTTTTTATTAGAAAACTC
CAGCAAGGTGGTCCGGGACTACAATCTTCAGCTGTTTTTGCAAGAAAACGCTGTATTTCACAAACCCCAGCCCTTCCAGTTCCAGCCTTG
TGACAGTGATACTAGTTTAAAAGCCGCCCAACTGGTGGATATTGAGCTCTCCCCTGTCAGTGCTCTGAGAATGACCATAGCTGAGAGCCG
ACAGTTAGAATCAGAAACTGGGACCACAGAGGAGCACAGTCTAAATAAGGAAGCTCGAAAATGGGCCACACGTGTGGCACGTGAGCATAA
AAACATTGTTCACCAACAACGGGTTCTAAATGATCTGGAGTGTCATGGAGCTGCTGTATCAGAACAAAGCCGAGCAGAGCTAGAACAGAA
AATAGATGAAGCTAGAGAAAATATTCGTAAAGCAGAGATAATTAAATTGAAAGCTGAAGCCCGGTTGGACCTGCTAAAGCAGATTGGTGT
TTCTGTGGACACATGGCTAAAGAGTGCCATGAACCAAGTAATGGAAGAACTGGAAAATGAGCGATGGGCCCGCCCTCCTGCAGTGACCAG
TAATGGCACTTTACACTCGGACATGCGGAAGCACGTGGCCATGACCCTGCTGGACACAGAGCAGTCGTATGTGGAGTCGCTGCGCACCCT
GATGCAGGGCTACATGCAGCCGCTGAAGCAGCCAGAGAACTCCGTGCTCTGTGACCCTTCACTGGTGGACGAGATCTTCGACCAGATCCC
CGAGCTCCTGGAGCACCACGAGCAATTCCTGGAGCAGGTTCGGCACTGCATGCAGACCTGGCATGCCCAGCAGAAGGTGGGAGCCCTGCT
CGTCCAGTCGTTCTCCAAGGATGTCCTAGTAAACATCTATTCTGCCTATATCGATAACTTCCTCAATGCAAAGGATGCTGTGCGTGTGGC
CAAGGAGGCGAGGCCTGCCTTTCTCAAGTTCCTAGAGCAAAGCATGCGTGAGAACAAGGAGAAGCAGGCGCTGTCTGACCTCATGATCAA
GCCTGTGCAGCGGATCCCACGCTACGAGCTTCTGGTGAAGGACCTCCTGAAGCATACACCTGAGGACCACCCGGACCATCCACTCCTGCT
GGAGGCGCAGCGGAACATCAAGCAGGTGGCTGAGCGCATCAACAAGGGTGTGCGGAGTGCCGAGGAGGCGGAGCGCCATGCCCGTGTGCT
GCAGGAGATAGAGGCTCACATCGAGGGCATGGAGGATCTCCAGGCCCCTCTGCGGCGGTTCCTGAGACAGGAGATGGTCATTGAAGTGAA
GGCGATCGGTGGCAAGAAGGACCGGTCTCTCTTCCTGTTCACGGACCTCATCGTCTGCACCACTCTGAAGCGAAAGTCAGGCTCCCTGCG
GCGCAGCTCCATGAGCCTGTACACGGCAGCCAGTGTCATTGACACAGCCAGCAAGTACAAGATGCTGTGGAAGCTGCCGCTGGAAGACGC
AGACATCATCAAAGGGGCATCCCAAGCCACCAATCGGGAGAACATCCAGAAGGCCATCAGCCGCCTTGATGAGGACCTCACCACCCTGGG
CCAAATGAGCAAGCTCTCTGAGAGCCTTGGTTTCCCCCACCAGAGCCTGGACGATGCACTGCGGGACCTCTCAGCTGCCATGCACCGGGA
CCTGTCGGAGAAGCAGGCGCTGTGCTACGCGCTTTCCTTCCCGCCAACCAAGCTGGAGCTGTGCGCCACTCGGCCCGAGGGCACCGACTC
CTACATTTTTGAGTTCCCTCACCCTGACGCCCGCCTTGGTTTTGAACAGGCCTTCGATGAGGCCAAGAGGAAGCTGGCATCCAGCAAAAG
CTGTCTAGACCCTGAGTTCCTGAAGGCCATCCCCATCATGAAAACCCGCAGTGGCATGCAGTTCTCCTGTGCGGCTCCCACCCTGAACAG
CTGCCCGGAGCCCTCGCCTGAGGTATGGGTCTGCAACAGCGACGGCTACGTGGGCCAGGTGTGCCTGCTGAGCCTGCGCGCCGAGCCGGA
CGTGGAGGCCTGCATCGCCGTCTGTTCCGCCCGCATCCTCTGCATCGGGGCGGTGCCCGGGCTGCAGCCTCGCTGCCACCGGGAGCCTCC
TCCGTCGCTGAGGAGTCCTCCAGAGACGGCACCGGAGCCCGCCGGGCCGGAGCTGGACGTCGAGGCCGCTGCAGACGAGGAAGCCGCGAC
GCTCGCGGAGCCGGGGCCGCAGCCCTGCCTTCACATCTCCATTGCAGGCTCGGGCTTGGAGATGACGCCGGGCCTCGGCGAGGGTGACCC
CCGCCCAGAGCTGGTGCCCTTTGACAGTGACTCTGACGATGAGTCTTCGCCCAGCCCCTCGGGGACGCTGCAGAGCCAGGCCAGCCGGTC
CACCATCTCCTCCAGCTTTGGCAATGAGGAGACCCCGAGTTCCAAGGAGGCCACGGCAGAGACCACCAGCTCAGAGGAGGAGCAGGAGCC
AGGCTTCCTGCCACTGTCTGGCTCCTTTGGGCCTGGTGGTCCCTGCGGCACCAGCCCAATGGATGGGAGAGCCCTTCGCCGCTCCAGCCA
CGGCTCCTTCACCCGGGGCAGCCTTGAGGACCTGCTGAGTGTCGACCCTGAGGCCTACCAGAGCTCCGTGTGGCTGGGCACTGAGGATGG
CTGTGTCCACGTGTACCAGTCCTCCGACAGCATCCGTGACCGCAGGAACAGCATGAAGCTCCAGCATGCGGCCTCTGTGACCTGCATCTT
GTATCTGAATAACCAGGTGTTTGTGTCTCTGGCCAATGGAGAGCTTGTGGTCTACCAAAGGGAAGCAGGCCATTTCTGGGACCCCCAGAA
CTTCAAATCAGTGACCTTGGGCACCCAGGGGAGCCCCATCACCAAGATGGTATCTGTGGGTGGGCGGCTGTGGTGTGGCTGCCAGAACCG
AGTCCTTGTCCTGAGCCCTGACACGCTGCAGCTGGAGCACATGTTTTACGTGGGTCAGGATTCAAGCCGCTGCGTGGCTTGCATGGTGGA
CTCCAGCCTGGGTGTGTGGGTGACATTGAAAGGTAGTGCCCACGTGTGTCTCTACCATCCAGACACCTTTGAGCAGCTGGCAGAAGTAGA
CGTCACTCCTCCCGTGCACAGGATGCTGGCAGGCTCGGATGCCATCATCCGGCAGCACAAGGCTGCCTGTCTGCGAATCACAGCGCTGCT
GGTGTGTGAGGAGCTGCTGTGGGTGGGCACCAGTGCTGGTGTCGTCCTCACCATGCCCACTTCGCCCGGTACTGTCAGCTGCCCACGGGC
ACCACTCAGTCCCACAGGCCTCGGCCAGGGACACACCGGCCACGTCCGCTTCTTGGCTGCAGTCCAGCTGCCAGATGGCTTCAACCTGCT
CTGCCCAACCCCACCACCTCCCCCAGACACAGGCCCCGAGAAGCTGCCATCACTGGAGCACCGGGACTCCCCTTGGCACCGAGGCCCCGC
CCCTGCCAGGCCTAAAATGCTGGTTATCAGTGGAGGTGATGGCTATGAGGACTTCCGACTCAGCAGTGGGGGCGGCAGCAGCAGTGAGAC
TGTGGGTCGAGACGACAGCACAAACCACCTCCTCCTGTGGAGGGTGTGACCCTGTCTGCCGTGGCCCAGGACTCGCCCGCCCACCTGCCT
TCAGCCTGCTTGCCTCTCCCTAGCCCACACGCAGACTTTGACCAGGAGTATCCAGCCAGGGGCACACATGTGCCTGCGTGGGCTCTGCCT
TGTCTTCGCGGAAGCATTCCTGATGGAACACCCACTGGCCAGCCAGGCCATGGCTTCTCCCGACCCTCTGGCTGCCCCGGTGCTTCCAGT
CATGATCGGGTGGGGGACATGTGGGCTGACCAGGACCTCTGACCCTGGAGCTTCTACCAAAGACACAGCTGGGTCTGGACCCCACGGGGC
TGGGGAGGGCCATGTGCAATATTTGGAGGGTTTTCTGGAGGGCAGCAGGAAGGCTGGGGAATTCCCCATGTACAGTATTTATGTTTCTTT
TTAGATGTGTACCTTCCCAAGCACTTATTTATGCAGTGACCTGGTCACCTGGGGTGGGGGTGATTTGAGGAAATGACATGAGGAAAAGAA
ACCTATTCCTGCCCTGGGGACCACCCTGGGACTCTAACCAAGCCTTCCTGGAGGGACCCATGCGCCCCTGAGCCCCATTCCATTCATACA
GACACACACGTACGCACACTGCATGTCCAAGGCCCTAAACATTGCCCGTTGACATAAACTTTCCAGGGCCCCAGCCTGATGGGGCTGCCC
TCAGTCCTCTAGATCAAGATGCTGACTATTAGGGGGCAGTGATTGCCATCTGGGGACCTGTCAGGCTTTGTCATTTCCCAGTTTGTTGGT
GGTGCCTTTAGTGGTTCCCTAATTTGGGAACACTGATGGGGCCTTGGACAGGGCTTTCTCTCAGGTAGGAGAAATGGGCCCATGATCTCC
TCACAGTCGCCCCCAGTCCTTGGCCCTGCTTCCCTGTGTCTCATGCACTGGCACATATGGTCACCTTGGAGGGCAGACCTAGGAGCCCCT
CTGACCACTGAATCCGTCTCCACACCCCTTCTGCCAAGGGAAGCCCCTTCAGGAAGGACCCCCCAAAGCTGAGGGGCTGAATGTAGCCTT
TTCAACAGAGAAGGCTCCCACTTGAGAGCAGCCTCTACCTGACCCCCTGGACCACAGAGAGCCACTCTGACCCTCAGCCCCCTCGCTTCT
TCAGCTAAAACTCCAAAGGTTTGGTTTCAGATGGGGTTTGTTTTGTTCTGTTTGGTTTTGGTTTTGTTTGGGGTGGGTGGGTCATTGCGG
TCTTAGATTATGTTTCTCTTGCTACCAAACAGTCATGTATTAACTCTCTTTGGATGATGAAGTTTAAAGAGTCAATAAATAGAAACACCA

>29981_29981_2_FCHSD2-ARHGEF17_FCHSD2_chr11_72578910_ENST00000409314_ARHGEF17_chr11_73057928_ENST00000263674_length(amino acids)=1459AA_BP=455
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSF
LEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLF
QSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFL
LENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSLKAAQLVDIELSPVSALRMTIAESRQLESETGTTEEHSLNKEARKWATRVA
REHKNIVHQQRVLNDLECHGAAVSEQSRAELEQKIDEARENIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENERWARPP
AVTSNGTLHSDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKV
GALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDH
PLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKS
GSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQATNRENIQKAISRLDEDLTTLGQMSKLSESLGFPHQSLDDALRDLSAA
MHRDLSEKQALCYALSFPPTKLELCATRPEGTDSYIFEFPHPDARLGFEQAFDEAKRKLASSKSCLDPEFLKAIPIMKTRSGMQFSCAAP
TLNSCPEPSPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCSARILCIGAVPGLQPRCHREPPPSLRSPPETAPEPAGPELDVEAAADE
EAATLAEPGPQPCLHISIAGSGLEMTPGLGEGDPRPELVPFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSKEATAETTSSEE
EQEPGFLPLSGSFGPGGPCGTSPMDGRALRRSSHGSFTRGSLEDLLSVDPEAYQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASV
TCILYLNNQVFVSLANGELVVYQREAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVA
CMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTVS
CPRAPLSPTGLGQGHTGHVRFLAAVQLPDGFNLLCPTPPPPPDTGPEKLPSLEHRDSPWHRGPAPARPKMLVISGGDGYEDFRLSSGGGS

--------------------------------------------------------------
>29981_29981_3_FCHSD2-ARHGEF17_FCHSD2_chr11_72578910_ENST00000409418_ARHGEF17_chr11_73057928_ENST00000263674_length(transcript)=6003nt_BP=1692nt
GGCGGCGCAGGCGGCCGACCGGGAGCGCGGACAACGCGGCTGCGGCTAACCCGCCGCCCGGCCGGCTGAGACCCTCGCGCCCCTGCTCCT
GGGGCCCCCGCCCCCTCGCCGTCTCCGCCTCCTTCCTCACACACCCCCGGGCCGCCCGGGCCGCCCGGGCCCCAAGCCTTCCCGGTGCTC
CTCCCTCGTCTCCTCACACTCGCTCTCTGGCTGGGGTCCGCCTGCCGCCCGCTGGCCTGCTCCCTCCGGGGCAAGTCTTGCTTCTTAAGC
GCTCCTTTCACACACGCGCGCGCTCGCTGGGCCGTCCCCTCCTCTCCGGCCCTCCTCCTCCTCCTGGTCCTTGCTAACGCTGCCGTCGGG
GAGGATTGATGTCCCTTCAGCATCATGCAGCCGCCGCCGAGGAAGGTGAAAGTTACACAAGAACTGAAAAACATTCAAGTTGAGCAGATG
ACAAAACTTCAAGCCAAACATCAAGCAGAATGTGATTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCTATTGAAAGAGAG
TATGCACAGGGTATGCAGAAGTTGGCTAGTCAATACCTGAAGAGAGATTGGCCTGGAGTAAAAGCTGATGATCGGAATGATTACAGGAGC
ATGTATCCCGTTTGGAAATCTTTTCTCGAGGGAACAATGCAGGTAGCCCAGTCTCGGATGAATATATGTGAAAACTATAAAAACTTCATT
TCTGAGCCTGCAAGGACAGTGAGAAGCTTAAAAGAACAGCAACTAAAAAGGTGTGTGGACCAGTTGACAAAGATCCAAACTGAATTACAA
GAGACAGTGAAAGATTTAGCTAAAGGCAAAAAGAAATACTTTGAGACTGAACAGATGGCTCATGCAGTACGAGAGAAAGCTGACATCGAG
GCAAAATCTAAACTTAGTCTTTTTCAATCAAGAATCAGTTTACAGAAGGCAAGTGTAAAGTTAAAAGCCCGGCGATCTGAGTGTAATTCC
AAAGCTACCCACGCAAGGAATGATTATCTTCTTACCCTAGCGGCAGCAAATGCACATCAGGATCGCTACTATCAAACAGATTTAGTTAAC
ATTATGAAGGCTCTTGATGGAAATGTGTATGATCATCTCAAGGATTATTTAATAGCCTTCAGCCGGACTGAGCTAGAAACATGCCAAGCT
GTGCAGAACACATTCCAGTTTTTATTAGAAAACTCCAGCAAGGTGGTCCGGGACTACAATCTTCAGCTGTTTTTGCAAGAAAACGCTGTA
TTTCACAAACCCCAGCCCTTCCAGTTCCAGCCTTGTGACAGTGATACTAGCCGACAGTTAGAATCAGAAACTGGGACCACAGAGGAGCAC
AGTCTAAATAAGGAAGCTCGAAAATGGGCCACACGTGTGGCACGTGAGCATAAAAACATTGTTCACCAACAACGGGTTCTAAATGATCTG
GAGTGTCATGGAGCTGCTGTATCAGAACAAAGCCGAGCAGAGCTAGAACAGAAAATAGATGAAGCTAGAGAAAATATTCGTAAAGCAGAG
ATAATTAAATTGAAAGCTGAAGCCCGGTTGGACCTGCTAAAGCAGATTGGTGTTTCTGTGGACACATGGCTAAAGAGTGCCATGAACCAA
GTAATGGAAGAACTGGAAAATGAGCGATGGGCCCGCCCTCCTGCAGTGACCAGTAATGGCACTTTACACTCGGACATGCGGAAGCACGTG
GCCATGACCCTGCTGGACACAGAGCAGTCGTATGTGGAGTCGCTGCGCACCCTGATGCAGGGCTACATGCAGCCGCTGAAGCAGCCAGAG
AACTCCGTGCTCTGTGACCCTTCACTGGTGGACGAGATCTTCGACCAGATCCCCGAGCTCCTGGAGCACCACGAGCAATTCCTGGAGCAG
GTTCGGCACTGCATGCAGACCTGGCATGCCCAGCAGAAGGTGGGAGCCCTGCTCGTCCAGTCGTTCTCCAAGGATGTCCTAGTAAACATC
TATTCTGCCTATATCGATAACTTCCTCAATGCAAAGGATGCTGTGCGTGTGGCCAAGGAGGCGAGGCCTGCCTTTCTCAAGTTCCTAGAG
CAAAGCATGCGTGAGAACAAGGAGAAGCAGGCGCTGTCTGACCTCATGATCAAGCCTGTGCAGCGGATCCCACGCTACGAGCTTCTGGTG
AAGGACCTCCTGAAGCATACACCTGAGGACCACCCGGACCATCCACTCCTGCTGGAGGCGCAGCGGAACATCAAGCAGGTGGCTGAGCGC
ATCAACAAGGGTGTGCGGAGTGCCGAGGAGGCGGAGCGCCATGCCCGTGTGCTGCAGGAGATAGAGGCTCACATCGAGGGCATGGAGGAT
CTCCAGGCCCCTCTGCGGCGGTTCCTGAGACAGGAGATGGTCATTGAAGTGAAGGCGATCGGTGGCAAGAAGGACCGGTCTCTCTTCCTG
TTCACGGACCTCATCGTCTGCACCACTCTGAAGCGAAAGTCAGGCTCCCTGCGGCGCAGCTCCATGAGCCTGTACACGGCAGCCAGTGTC
ATTGACACAGCCAGCAAGTACAAGATGCTGTGGAAGCTGCCGCTGGAAGACGCAGACATCATCAAAGGGGCATCCCAAGCCACCAATCGG
GAGAACATCCAGAAGGCCATCAGCCGCCTTGATGAGGACCTCACCACCCTGGGCCAAATGAGCAAGCTCTCTGAGAGCCTTGGTTTCCCC
CACCAGAGCCTGGACGATGCACTGCGGGACCTCTCAGCTGCCATGCACCGGGACCTGTCGGAGAAGCAGGCGCTGTGCTACGCGCTTTCC
TTCCCGCCAACCAAGCTGGAGCTGTGCGCCACTCGGCCCGAGGGCACCGACTCCTACATTTTTGAGTTCCCTCACCCTGACGCCCGCCTT
GGTTTTGAACAGGCCTTCGATGAGGCCAAGAGGAAGCTGGCATCCAGCAAAAGCTGTCTAGACCCTGAGTTCCTGAAGGCCATCCCCATC
ATGAAAACCCGCAGTGGCATGCAGTTCTCCTGTGCGGCTCCCACCCTGAACAGCTGCCCGGAGCCCTCGCCTGAGGTATGGGTCTGCAAC
AGCGACGGCTACGTGGGCCAGGTGTGCCTGCTGAGCCTGCGCGCCGAGCCGGACGTGGAGGCCTGCATCGCCGTCTGTTCCGCCCGCATC
CTCTGCATCGGGGCGGTGCCCGGGCTGCAGCCTCGCTGCCACCGGGAGCCTCCTCCGTCGCTGAGGAGTCCTCCAGAGACGGCACCGGAG
CCCGCCGGGCCGGAGCTGGACGTCGAGGCCGCTGCAGACGAGGAAGCCGCGACGCTCGCGGAGCCGGGGCCGCAGCCCTGCCTTCACATC
TCCATTGCAGGCTCGGGCTTGGAGATGACGCCGGGCCTCGGCGAGGGTGACCCCCGCCCAGAGCTGGTGCCCTTTGACAGTGACTCTGAC
GATGAGTCTTCGCCCAGCCCCTCGGGGACGCTGCAGAGCCAGGCCAGCCGGTCCACCATCTCCTCCAGCTTTGGCAATGAGGAGACCCCG
AGTTCCAAGGAGGCCACGGCAGAGACCACCAGCTCAGAGGAGGAGCAGGAGCCAGGCTTCCTGCCACTGTCTGGCTCCTTTGGGCCTGGT
GGTCCCTGCGGCACCAGCCCAATGGATGGGAGAGCCCTTCGCCGCTCCAGCCACGGCTCCTTCACCCGGGGCAGCCTTGAGGACCTGCTG
AGTGTCGACCCTGAGGCCTACCAGAGCTCCGTGTGGCTGGGCACTGAGGATGGCTGTGTCCACGTGTACCAGTCCTCCGACAGCATCCGT
GACCGCAGGAACAGCATGAAGCTCCAGCATGCGGCCTCTGTGACCTGCATCTTGTATCTGAATAACCAGGTGTTTGTGTCTCTGGCCAAT
GGAGAGCTTGTGGTCTACCAAAGGGAAGCAGGCCATTTCTGGGACCCCCAGAACTTCAAATCAGTGACCTTGGGCACCCAGGGGAGCCCC
ATCACCAAGATGGTATCTGTGGGTGGGCGGCTGTGGTGTGGCTGCCAGAACCGAGTCCTTGTCCTGAGCCCTGACACGCTGCAGCTGGAG
CACATGTTTTACGTGGGTCAGGATTCAAGCCGCTGCGTGGCTTGCATGGTGGACTCCAGCCTGGGTGTGTGGGTGACATTGAAAGGTAGT
GCCCACGTGTGTCTCTACCATCCAGACACCTTTGAGCAGCTGGCAGAAGTAGACGTCACTCCTCCCGTGCACAGGATGCTGGCAGGCTCG
GATGCCATCATCCGGCAGCACAAGGCTGCCTGTCTGCGAATCACAGCGCTGCTGGTGTGTGAGGAGCTGCTGTGGGTGGGCACCAGTGCT
GGTGTCGTCCTCACCATGCCCACTTCGCCCGGTACTGTCAGCTGCCCACGGGCACCACTCAGTCCCACAGGCCTCGGCCAGGGACACACC
GGCCACGTCCGCTTCTTGGCTGCAGTCCAGCTGCCAGATGGCTTCAACCTGCTCTGCCCAACCCCACCACCTCCCCCAGACACAGGCCCC
GAGAAGCTGCCATCACTGGAGCACCGGGACTCCCCTTGGCACCGAGGCCCCGCCCCTGCCAGGCCTAAAATGCTGGTTATCAGTGGAGGT
GATGGCTATGAGGACTTCCGACTCAGCAGTGGGGGCGGCAGCAGCAGTGAGACTGTGGGTCGAGACGACAGCACAAACCACCTCCTCCTG
TGGAGGGTGTGACCCTGTCTGCCGTGGCCCAGGACTCGCCCGCCCACCTGCCTTCAGCCTGCTTGCCTCTCCCTAGCCCACACGCAGACT
TTGACCAGGAGTATCCAGCCAGGGGCACACATGTGCCTGCGTGGGCTCTGCCTTGTCTTCGCGGAAGCATTCCTGATGGAACACCCACTG
GCCAGCCAGGCCATGGCTTCTCCCGACCCTCTGGCTGCCCCGGTGCTTCCAGTCATGATCGGGTGGGGGACATGTGGGCTGACCAGGACC
TCTGACCCTGGAGCTTCTACCAAAGACACAGCTGGGTCTGGACCCCACGGGGCTGGGGAGGGCCATGTGCAATATTTGGAGGGTTTTCTG
GAGGGCAGCAGGAAGGCTGGGGAATTCCCCATGTACAGTATTTATGTTTCTTTTTAGATGTGTACCTTCCCAAGCACTTATTTATGCAGT
GACCTGGTCACCTGGGGTGGGGGTGATTTGAGGAAATGACATGAGGAAAAGAAACCTATTCCTGCCCTGGGGACCACCCTGGGACTCTAA
CCAAGCCTTCCTGGAGGGACCCATGCGCCCCTGAGCCCCATTCCATTCATACAGACACACACGTACGCACACTGCATGTCCAAGGCCCTA
AACATTGCCCGTTGACATAAACTTTCCAGGGCCCCAGCCTGATGGGGCTGCCCTCAGTCCTCTAGATCAAGATGCTGACTATTAGGGGGC
AGTGATTGCCATCTGGGGACCTGTCAGGCTTTGTCATTTCCCAGTTTGTTGGTGGTGCCTTTAGTGGTTCCCTAATTTGGGAACACTGAT
GGGGCCTTGGACAGGGCTTTCTCTCAGGTAGGAGAAATGGGCCCATGATCTCCTCACAGTCGCCCCCAGTCCTTGGCCCTGCTTCCCTGT
GTCTCATGCACTGGCACATATGGTCACCTTGGAGGGCAGACCTAGGAGCCCCTCTGACCACTGAATCCGTCTCCACACCCCTTCTGCCAA
GGGAAGCCCCTTCAGGAAGGACCCCCCAAAGCTGAGGGGCTGAATGTAGCCTTTTCAACAGAGAAGGCTCCCACTTGAGAGCAGCCTCTA
CCTGACCCCCTGGACCACAGAGAGCCACTCTGACCCTCAGCCCCCTCGCTTCTTCAGCTAAAACTCCAAAGGTTTGGTTTCAGATGGGGT
TTGTTTTGTTCTGTTTGGTTTTGGTTTTGTTTGGGGTGGGTGGGTCATTGCGGTCTTAGATTATGTTTCTCTTGCTACCAAACAGTCATG

>29981_29981_3_FCHSD2-ARHGEF17_FCHSD2_chr11_72578910_ENST00000409418_ARHGEF17_chr11_73057928_ENST00000263674_length(amino acids)=1435AA_BP=431
MQPPPRKVKVTQELKNIQVEQMTKLQAKHQAECDLLEDMRTFSQKKAAIEREYAQGMQKLASQYLKRDWPGVKADDRNDYRSMYPVWKSF
LEGTMQVAQSRMNICENYKNFISEPARTVRSLKEQQLKRCVDQLTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLF
QSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQDRYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFL
LENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLECHGAAVS
EQSRAELEQKIDEARENIRKAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENERWARPPAVTSNGTLHSDMRKHVAMTLLDTE
QSYVESLRTLMQGYMQPLKQPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNF
LNAKDAVRVAKEARPAFLKFLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSA
EEAERHARVLQEIEAHIEGMEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVIDTASKYK
MLWKLPLEDADIIKGASQATNRENIQKAISRLDEDLTTLGQMSKLSESLGFPHQSLDDALRDLSAAMHRDLSEKQALCYALSFPPTKLEL
CATRPEGTDSYIFEFPHPDARLGFEQAFDEAKRKLASSKSCLDPEFLKAIPIMKTRSGMQFSCAAPTLNSCPEPSPEVWVCNSDGYVGQV
CLLSLRAEPDVEACIAVCSARILCIGAVPGLQPRCHREPPPSLRSPPETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLE
MTPGLGEGDPRPELVPFDSDSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSKEATAETTSSEEEQEPGFLPLSGSFGPGGPCGTSPM
DGRALRRSSHGSFTRGSLEDLLSVDPEAYQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQR
EAGHFWDPQNFKSVTLGTQGSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHP
DTFEQLAEVDVTPPVHRMLAGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLGQGHTGHVRFLAA

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>29981_29981_4_FCHSD2-ARHGEF17_FCHSD2_chr11_72578910_ENST00000458644_ARHGEF17_chr11_73057928_ENST00000263674_length(transcript)=5582nt_BP=1271nt
GCTGCCGTCGGGGAGGATTGATGTCCCTTCAGCATCATGCAGCCGCCGCCGAGGAAGGTGAAAGTTACACAAGAACTGAAAAACATTCAA
GTTGAGCAGATGACAAAACTTCAAGCCAAACATCAAGCAGAATGTGATTTGCTTGAAGATATGAGGACATTCAGTCAGAAGAAGGCTGCT
ATTGAAAGAGAGTATGCACAGGGTATGCAGAAGTTGGCTAGTCAATACCTGAAGAGAGATTGGCCTGGAGTAAAAGCTGATGATCGGAAT
GATTACAGTGTGTGGACCAGTTGACAAAGATCCAAACTGAATTACAAGAGACAGTGAAAGATTTAGCTAAAGGCAAAAAGAAATACTTTG
AGACTGAACAGATGGCTCATGCAGTACGAGAGAAAGCTGACATCGAGGCAAAATCTAAACTTAGTCTTTTTCAATCAAGAATCAGTTTAC
AGAAGGCAAGTGTAAAGTTAAAAGCCCGGCGATCTGAGTGTAATTCCAAAGCTACCCACGCAAGGAATGATTATCTTCTTACCCTAGCGG
CAGCAAATGCACATCAGGATCGCTACTATCAAACAGATTTAGTTAACATTATGAAGGCTCTTGATGGAAATGTGTATGATCATCTCAAGG
ATTATTTAATAGCCTTCAGCCGGACTGAGCTAGAAACATGCCAAGCTGTGCAGAACACATTCCAGTTTTTATTAGAAAACTCCAGCAAGG
TGGTCCGGGACTACAATCTTCAGCTGTTTTTGCAAGAAAACGCTGTATTTCACAAACCCCAGCCCTTCCAGTTCCAGCCTTGTGACAGTG
ATACTAGTTTAAAAGCCGCCCAACTGGTGGATATTGAGCTCTCCCCTGTCAGTGCTCTGAGAATGACCATAGCTGAGAGCCGACAGTTAG
AATCAGAAACTGGGACCACAGAGGAGCACAGTCTAAATAAGGAAGCTCGAAAATGGGCCACACGTGTGGCACGTGAGCATAAAAACATTG
TTCACCAACAACGGGTTCTAAATGATCTGGAGTGTCATGGAGCTGCTGTATCAGAACAAAGCCGAGCAGAGCTAGAACAGAAAATAGATG
AAGCTAGAGAAAATATTCGTAAAGCAGAGATAATTAAATTGAAAGCTGAAGCCCGGTTGGACCTGCTAAAGCAGATTGGTGTTTCTGTGG
ACACATGGCTAAAGAGTGCCATGAACCAAGTAATGGAAGAACTGGAAAATGAGCGATGGGCCCGCCCTCCTGCAGTGACCAGTAATGGCA
CTTTACACTCGGACATGCGGAAGCACGTGGCCATGACCCTGCTGGACACAGAGCAGTCGTATGTGGAGTCGCTGCGCACCCTGATGCAGG
GCTACATGCAGCCGCTGAAGCAGCCAGAGAACTCCGTGCTCTGTGACCCTTCACTGGTGGACGAGATCTTCGACCAGATCCCCGAGCTCC
TGGAGCACCACGAGCAATTCCTGGAGCAGGTTCGGCACTGCATGCAGACCTGGCATGCCCAGCAGAAGGTGGGAGCCCTGCTCGTCCAGT
CGTTCTCCAAGGATGTCCTAGTAAACATCTATTCTGCCTATATCGATAACTTCCTCAATGCAAAGGATGCTGTGCGTGTGGCCAAGGAGG
CGAGGCCTGCCTTTCTCAAGTTCCTAGAGCAAAGCATGCGTGAGAACAAGGAGAAGCAGGCGCTGTCTGACCTCATGATCAAGCCTGTGC
AGCGGATCCCACGCTACGAGCTTCTGGTGAAGGACCTCCTGAAGCATACACCTGAGGACCACCCGGACCATCCACTCCTGCTGGAGGCGC
AGCGGAACATCAAGCAGGTGGCTGAGCGCATCAACAAGGGTGTGCGGAGTGCCGAGGAGGCGGAGCGCCATGCCCGTGTGCTGCAGGAGA
TAGAGGCTCACATCGAGGGCATGGAGGATCTCCAGGCCCCTCTGCGGCGGTTCCTGAGACAGGAGATGGTCATTGAAGTGAAGGCGATCG
GTGGCAAGAAGGACCGGTCTCTCTTCCTGTTCACGGACCTCATCGTCTGCACCACTCTGAAGCGAAAGTCAGGCTCCCTGCGGCGCAGCT
CCATGAGCCTGTACACGGCAGCCAGTGTCATTGACACAGCCAGCAAGTACAAGATGCTGTGGAAGCTGCCGCTGGAAGACGCAGACATCA
TCAAAGGGGCATCCCAAGCCACCAATCGGGAGAACATCCAGAAGGCCATCAGCCGCCTTGATGAGGACCTCACCACCCTGGGCCAAATGA
GCAAGCTCTCTGAGAGCCTTGGTTTCCCCCACCAGAGCCTGGACGATGCACTGCGGGACCTCTCAGCTGCCATGCACCGGGACCTGTCGG
AGAAGCAGGCGCTGTGCTACGCGCTTTCCTTCCCGCCAACCAAGCTGGAGCTGTGCGCCACTCGGCCCGAGGGCACCGACTCCTACATTT
TTGAGTTCCCTCACCCTGACGCCCGCCTTGGTTTTGAACAGGCCTTCGATGAGGCCAAGAGGAAGCTGGCATCCAGCAAAAGCTGTCTAG
ACCCTGAGTTCCTGAAGGCCATCCCCATCATGAAAACCCGCAGTGGCATGCAGTTCTCCTGTGCGGCTCCCACCCTGAACAGCTGCCCGG
AGCCCTCGCCTGAGGTATGGGTCTGCAACAGCGACGGCTACGTGGGCCAGGTGTGCCTGCTGAGCCTGCGCGCCGAGCCGGACGTGGAGG
CCTGCATCGCCGTCTGTTCCGCCCGCATCCTCTGCATCGGGGCGGTGCCCGGGCTGCAGCCTCGCTGCCACCGGGAGCCTCCTCCGTCGC
TGAGGAGTCCTCCAGAGACGGCACCGGAGCCCGCCGGGCCGGAGCTGGACGTCGAGGCCGCTGCAGACGAGGAAGCCGCGACGCTCGCGG
AGCCGGGGCCGCAGCCCTGCCTTCACATCTCCATTGCAGGCTCGGGCTTGGAGATGACGCCGGGCCTCGGCGAGGGTGACCCCCGCCCAG
AGCTGGTGCCCTTTGACAGTGACTCTGACGATGAGTCTTCGCCCAGCCCCTCGGGGACGCTGCAGAGCCAGGCCAGCCGGTCCACCATCT
CCTCCAGCTTTGGCAATGAGGAGACCCCGAGTTCCAAGGAGGCCACGGCAGAGACCACCAGCTCAGAGGAGGAGCAGGAGCCAGGCTTCC
TGCCACTGTCTGGCTCCTTTGGGCCTGGTGGTCCCTGCGGCACCAGCCCAATGGATGGGAGAGCCCTTCGCCGCTCCAGCCACGGCTCCT
TCACCCGGGGCAGCCTTGAGGACCTGCTGAGTGTCGACCCTGAGGCCTACCAGAGCTCCGTGTGGCTGGGCACTGAGGATGGCTGTGTCC
ACGTGTACCAGTCCTCCGACAGCATCCGTGACCGCAGGAACAGCATGAAGCTCCAGCATGCGGCCTCTGTGACCTGCATCTTGTATCTGA
ATAACCAGGTGTTTGTGTCTCTGGCCAATGGAGAGCTTGTGGTCTACCAAAGGGAAGCAGGCCATTTCTGGGACCCCCAGAACTTCAAAT
CAGTGACCTTGGGCACCCAGGGGAGCCCCATCACCAAGATGGTATCTGTGGGTGGGCGGCTGTGGTGTGGCTGCCAGAACCGAGTCCTTG
TCCTGAGCCCTGACACGCTGCAGCTGGAGCACATGTTTTACGTGGGTCAGGATTCAAGCCGCTGCGTGGCTTGCATGGTGGACTCCAGCC
TGGGTGTGTGGGTGACATTGAAAGGTAGTGCCCACGTGTGTCTCTACCATCCAGACACCTTTGAGCAGCTGGCAGAAGTAGACGTCACTC
CTCCCGTGCACAGGATGCTGGCAGGCTCGGATGCCATCATCCGGCAGCACAAGGCTGCCTGTCTGCGAATCACAGCGCTGCTGGTGTGTG
AGGAGCTGCTGTGGGTGGGCACCAGTGCTGGTGTCGTCCTCACCATGCCCACTTCGCCCGGTACTGTCAGCTGCCCACGGGCACCACTCA
GTCCCACAGGCCTCGGCCAGGGACACACCGGCCACGTCCGCTTCTTGGCTGCAGTCCAGCTGCCAGATGGCTTCAACCTGCTCTGCCCAA
CCCCACCACCTCCCCCAGACACAGGCCCCGAGAAGCTGCCATCACTGGAGCACCGGGACTCCCCTTGGCACCGAGGCCCCGCCCCTGCCA
GGCCTAAAATGCTGGTTATCAGTGGAGGTGATGGCTATGAGGACTTCCGACTCAGCAGTGGGGGCGGCAGCAGCAGTGAGACTGTGGGTC
GAGACGACAGCACAAACCACCTCCTCCTGTGGAGGGTGTGACCCTGTCTGCCGTGGCCCAGGACTCGCCCGCCCACCTGCCTTCAGCCTG
CTTGCCTCTCCCTAGCCCACACGCAGACTTTGACCAGGAGTATCCAGCCAGGGGCACACATGTGCCTGCGTGGGCTCTGCCTTGTCTTCG
CGGAAGCATTCCTGATGGAACACCCACTGGCCAGCCAGGCCATGGCTTCTCCCGACCCTCTGGCTGCCCCGGTGCTTCCAGTCATGATCG
GGTGGGGGACATGTGGGCTGACCAGGACCTCTGACCCTGGAGCTTCTACCAAAGACACAGCTGGGTCTGGACCCCACGGGGCTGGGGAGG
GCCATGTGCAATATTTGGAGGGTTTTCTGGAGGGCAGCAGGAAGGCTGGGGAATTCCCCATGTACAGTATTTATGTTTCTTTTTAGATGT
GTACCTTCCCAAGCACTTATTTATGCAGTGACCTGGTCACCTGGGGTGGGGGTGATTTGAGGAAATGACATGAGGAAAAGAAACCTATTC
CTGCCCTGGGGACCACCCTGGGACTCTAACCAAGCCTTCCTGGAGGGACCCATGCGCCCCTGAGCCCCATTCCATTCATACAGACACACA
CGTACGCACACTGCATGTCCAAGGCCCTAAACATTGCCCGTTGACATAAACTTTCCAGGGCCCCAGCCTGATGGGGCTGCCCTCAGTCCT
CTAGATCAAGATGCTGACTATTAGGGGGCAGTGATTGCCATCTGGGGACCTGTCAGGCTTTGTCATTTCCCAGTTTGTTGGTGGTGCCTT
TAGTGGTTCCCTAATTTGGGAACACTGATGGGGCCTTGGACAGGGCTTTCTCTCAGGTAGGAGAAATGGGCCCATGATCTCCTCACAGTC
GCCCCCAGTCCTTGGCCCTGCTTCCCTGTGTCTCATGCACTGGCACATATGGTCACCTTGGAGGGCAGACCTAGGAGCCCCTCTGACCAC
TGAATCCGTCTCCACACCCCTTCTGCCAAGGGAAGCCCCTTCAGGAAGGACCCCCCAAAGCTGAGGGGCTGAATGTAGCCTTTTCAACAG
AGAAGGCTCCCACTTGAGAGCAGCCTCTACCTGACCCCCTGGACCACAGAGAGCCACTCTGACCCTCAGCCCCCTCGCTTCTTCAGCTAA
AACTCCAAAGGTTTGGTTTCAGATGGGGTTTGTTTTGTTCTGTTTGGTTTTGGTTTTGTTTGGGGTGGGTGGGTCATTGCGGTCTTAGAT
TATGTTTCTCTTGCTACCAAACAGTCATGTATTAACTCTCTTTGGATGATGAAGTTTAAAGAGTCAATAAATAGAAACACCAGATGACTG

>29981_29981_4_FCHSD2-ARHGEF17_FCHSD2_chr11_72578910_ENST00000458644_ARHGEF17_chr11_73057928_ENST00000263674_length(amino acids)=1326AA_BP=322
MTKIQTELQETVKDLAKGKKKYFETEQMAHAVREKADIEAKSKLSLFQSRISLQKASVKLKARRSECNSKATHARNDYLLTLAAANAHQD
RYYQTDLVNIMKALDGNVYDHLKDYLIAFSRTELETCQAVQNTFQFLLENSSKVVRDYNLQLFLQENAVFHKPQPFQFQPCDSDTSLKAA
QLVDIELSPVSALRMTIAESRQLESETGTTEEHSLNKEARKWATRVAREHKNIVHQQRVLNDLECHGAAVSEQSRAELEQKIDEARENIR
KAEIIKLKAEARLDLLKQIGVSVDTWLKSAMNQVMEELENERWARPPAVTSNGTLHSDMRKHVAMTLLDTEQSYVESLRTLMQGYMQPLK
QPENSVLCDPSLVDEIFDQIPELLEHHEQFLEQVRHCMQTWHAQQKVGALLVQSFSKDVLVNIYSAYIDNFLNAKDAVRVAKEARPAFLK
FLEQSMRENKEKQALSDLMIKPVQRIPRYELLVKDLLKHTPEDHPDHPLLLEAQRNIKQVAERINKGVRSAEEAERHARVLQEIEAHIEG
MEDLQAPLRRFLRQEMVIEVKAIGGKKDRSLFLFTDLIVCTTLKRKSGSLRRSSMSLYTAASVIDTASKYKMLWKLPLEDADIIKGASQA
TNRENIQKAISRLDEDLTTLGQMSKLSESLGFPHQSLDDALRDLSAAMHRDLSEKQALCYALSFPPTKLELCATRPEGTDSYIFEFPHPD
ARLGFEQAFDEAKRKLASSKSCLDPEFLKAIPIMKTRSGMQFSCAAPTLNSCPEPSPEVWVCNSDGYVGQVCLLSLRAEPDVEACIAVCS
ARILCIGAVPGLQPRCHREPPPSLRSPPETAPEPAGPELDVEAAADEEAATLAEPGPQPCLHISIAGSGLEMTPGLGEGDPRPELVPFDS
DSDDESSPSPSGTLQSQASRSTISSSFGNEETPSSKEATAETTSSEEEQEPGFLPLSGSFGPGGPCGTSPMDGRALRRSSHGSFTRGSLE
DLLSVDPEAYQSSVWLGTEDGCVHVYQSSDSIRDRRNSMKLQHAASVTCILYLNNQVFVSLANGELVVYQREAGHFWDPQNFKSVTLGTQ
GSPITKMVSVGGRLWCGCQNRVLVLSPDTLQLEHMFYVGQDSSRCVACMVDSSLGVWVTLKGSAHVCLYHPDTFEQLAEVDVTPPVHRML
AGSDAIIRQHKAACLRITALLVCEELLWVGTSAGVVLTMPTSPGTVSCPRAPLSPTGLGQGHTGHVRFLAAVQLPDGFNLLCPTPPPPPD

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Fusion Gene PPI Analysis for FCHSD2-ARHGEF17


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for FCHSD2-ARHGEF17


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for FCHSD2-ARHGEF17


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFCHSD2C0087031Juvenile-Onset Still Disease1CTD_human
HgeneFCHSD2C3495559Juvenile arthritis1CTD_human
HgeneFCHSD2C3714758Juvenile psoriatic arthritis1CTD_human
HgeneFCHSD2C4552091Polyarthritis, Juvenile, Rheumatoid Factor Negative1CTD_human
HgeneFCHSD2C4704862Polyarthritis, Juvenile, Rheumatoid Factor Positive1CTD_human