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in Kim Lab

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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:ARHGAP44-ZSWIM7 (FusionGDB2 ID:HG9912TG125150)

Fusion Gene Summary for ARHGAP44-ZSWIM7

check button Fusion gene summary
Fusion gene informationFusion gene name: ARHGAP44-ZSWIM7
Fusion gene ID: hg9912tg125150
HgeneTgene
Gene symbol

ARHGAP44

ZSWIM7

Gene ID

9912

125150

Gene nameRho GTPase activating protein 44zinc finger SWIM-type containing 7
SynonymsNPC-A-10|RICH2SWS1
Cytomap('ARHGAP44')('ZSWIM7')

17p12

17p12

Type of geneprotein-codingprotein-coding
Descriptionrho GTPase-activating protein 44Rho-type GTPase-activating protein RICH2RhoGAP interacting with CIP4 homologs protein 2rho GTPase-activating protein RICH2zinc finger SWIM domain-containing protein 7SWIM domain-containing and Srs2-interacting protein 1 homologSWIM-type zinc finger domain-containing protein 7
Modification date2020031320200320
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000262444, ENST00000340825, 
ENST00000379672, ENST00000578087, 
Fusion gene scores* DoF score9 X 8 X 6=4324 X 3 X 4=48
# samples 94
** MAII scorelog2(9/432*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: ARHGAP44 [Title/Abstract] AND ZSWIM7 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointARHGAP44(12832363)-ZSWIM7(15884458), # samples:2
Anticipated loss of major functional domain due to fusion event.ARHGAP44-ZSWIM7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP44-ZSWIM7 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP44-ZSWIM7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ARHGAP44-ZSWIM7 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across ARHGAP44 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across ZSWIM7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SARCTCGA-KD-A5QT-01AARHGAP44chr17

12832363

-ZSWIM7chr17

15884458

-
ChimerDB4SARCTCGA-KD-A5QT-01AARHGAP44chr17

12832363

+ZSWIM7chr17

15884458

-


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Fusion Gene ORF analysis for ARHGAP44-ZSWIM7

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000262444ENST00000399280ARHGAP44chr17

12832363

+ZSWIM7chr17

15884458

-
5CDS-5UTRENST00000340825ENST00000399280ARHGAP44chr17

12832363

+ZSWIM7chr17

15884458

-
5CDS-5UTRENST00000379672ENST00000399280ARHGAP44chr17

12832363

+ZSWIM7chr17

15884458

-
5CDS-intronENST00000262444ENST00000472495ARHGAP44chr17

12832363

+ZSWIM7chr17

15884458

-
5CDS-intronENST00000262444ENST00000486655ARHGAP44chr17

12832363

+ZSWIM7chr17

15884458

-
5CDS-intronENST00000340825ENST00000472495ARHGAP44chr17

12832363

+ZSWIM7chr17

15884458

-
5CDS-intronENST00000340825ENST00000486655ARHGAP44chr17

12832363

+ZSWIM7chr17

15884458

-
5CDS-intronENST00000379672ENST00000472495ARHGAP44chr17

12832363

+ZSWIM7chr17

15884458

-
5CDS-intronENST00000379672ENST00000486655ARHGAP44chr17

12832363

+ZSWIM7chr17

15884458

-
In-frameENST00000262444ENST00000399277ARHGAP44chr17

12832363

+ZSWIM7chr17

15884458

-
In-frameENST00000340825ENST00000399277ARHGAP44chr17

12832363

+ZSWIM7chr17

15884458

-
In-frameENST00000379672ENST00000399277ARHGAP44chr17

12832363

+ZSWIM7chr17

15884458

-
intron-3CDSENST00000578087ENST00000399277ARHGAP44chr17

12832363

+ZSWIM7chr17

15884458

-
intron-5UTRENST00000578087ENST00000399280ARHGAP44chr17

12832363

+ZSWIM7chr17

15884458

-
intron-intronENST00000578087ENST00000472495ARHGAP44chr17

12832363

+ZSWIM7chr17

15884458

-
intron-intronENST00000578087ENST00000486655ARHGAP44chr17

12832363

+ZSWIM7chr17

15884458

-

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000379672ARHGAP44chr1712832363+ENST00000399277ZSWIM7chr1715884458-25918823001103267
ENST00000340825ARHGAP44chr1712832363+ENST00000399277ZSWIM7chr1715884458-25918823001103267
ENST00000262444ARHGAP44chr1712832363+ENST00000399277ZSWIM7chr1715884458-237066179882267

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379672ENST00000399277ARHGAP44chr1712832363+ZSWIM7chr1715884458-0.0087558280.9912442
ENST00000340825ENST00000399277ARHGAP44chr1712832363+ZSWIM7chr1715884458-0.0087558280.9912442
ENST00000262444ENST00000399277ARHGAP44chr1712832363+ZSWIM7chr1715884458-0.0062061550.99379385

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Fusion Genomic Features for ARHGAP44-ZSWIM7


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

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Fusion Protein Features for ARHGAP44-ZSWIM7


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:12832363/chr17:15884458)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneZSWIM7chr17:12832363chr17:15884458ENST000003992772566_11467141.0Zinc fingerSWIM-type
TgeneZSWIM7chr17:12832363chr17:15884458ENST000004724952666_11467180.66666666666666Zinc fingerSWIM-type

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneARHGAP44chr17:12832363chr17:15884458ENST00000379672+72114_249194819.0DomainBAR
HgeneARHGAP44chr17:12832363chr17:15884458ENST00000379672+721255_445194819.0DomainRho-GAP
HgeneARHGAP44chr17:12832363chr17:15884458ENST00000379672+721815_818194819.0MotifPDZ-binding


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Fusion Gene Sequence for ARHGAP44-ZSWIM7


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>6128_6128_1_ARHGAP44-ZSWIM7_ARHGAP44_chr17_12832363_ENST00000262444_ZSWIM7_chr17_15884458_ENST00000399277_length(transcript)=2370nt_BP=661nt
GAGCCATGTAACCCTGCGGCGGGCTCCGGGCTGCTCCGTCCTTCCCCAGCTCCCGGGCTAGCGCGGCAGCGGGGCCACGATGAAGAAGCA
GTTCAATCGCATGCGCCAGCTGGCCAACCAGACGGTGGGCAGGGCTGAAAAGACAGAAGTTTTGAGTGAAGACCTTCTTCAGGTGGAGAA
GCGTCTGGAGCTGGTGAAACAGGTGTCCCACAGCACGCACAAGAAGCTCACCGCATGTCTGCAGGGCCAGCAAGGGGCAGAGGCTGACAA
GCGCTCCAAAAAGTTGCCTTTGACAACACTGGCTCAGTGTCTGATGGAGGGGTCAGCTATCCTGGGAGATGACACACTTCTTGGGAAGAT
GCTGAAACTCTGTGGAGAGACGGAGGACAAGCTGGCTCAGGAGCTGATACATTTTGAGTTGCAAGTAGAGAGAGACGTGATTGAGCCCCT
GTTTTTGCTGGCGGAGGTGGAAATCCCAAATATTCAAAAGCAGAGGAAACACTTAGCCAAGTTGGTGCTGGACATGGATTCCTCACGAAC
CAGGTGGCAGCAGACTTCCAAGTCTTCAGGTTTGTCCAGCAGCTTACAGCCTGCGGGTGCCAAGGCTGATGCCCTCAGGGAAGAAATGGA
AGAGGCTGCCAACAGAGTGGAGATTTGCAGGGTCCTTGGAAGTTCCAGTAAAACATACACATGTTTGGCTTCTTGTCATTACTGTTCATG
TCCTGCATTTGCATTCTCAGTGCTACGGAAGAGTGACAGCATCCTGTGCAAGCATCTCTTGGCAGTTTACCTGAGTCAGGTTATGAGGAC
CTGTCAGCAGCTAAGTGTCTCTGACAAGCAGTTGACTGACATATTATTGATGGAGAAGAAACAAGAAGCATAAAAGGTACAGATTGAGCA
TCATTCTTTCAAAATAGAATCCTGTCAAGAAATGCATTGAAAGCGTCATGATTCACATGGAAAAGAGGTGAAATGGATCTTCAGACACTT
CATGTTACTGTCCCTTTTCCCTCCAGGACTGCAGGAGGTGCTGTGGGTTGGAGCCGTGGGCTGTGGAGGGTTTGTGTATGATGAGAAGCC
CTGTACAGTCTTGTCAAGAAATACCCTGAGCCAGTCTCTGAGACGCTTCGGTAAAAAATGTCCCTGGATGGAATCAAGATTTTAAATTCA
AATAAAGCCTAATATCATGTTGTGTCCACATTATTTAGTCTTTTTTTTTTTCTTTTGAGATGGAGTCTCACTTTGTCGCCCAGGCTGGGG
TGCAGTGGCGTGATCTCAGCTCACTGCAAGCTCCGCCTCCCGGGTTCACGCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACA
GGTACCCGCCACCATGCCCGGCTAAATTTTTGTATTTTTTTTTTAGTAGAGATGGGGTTTCACCGTGTTAGCCAGGATGGTCTCCATCTC
CTGACCTAGTGGTCTGCCCGCCTCGACCTCCCAAAGTGCTGGAATTACATGCATGAGCCACTGCGCCTGACCCTATTTAGTCTTAAGTAA
CTAACTGAATTACTAGTAATTTTTAAAAGGTTGGAATGGTGGGCCAAACAGTAAGATGAAGTTTCGACGAGTAGGTCAGTTCTTTTCCTT
GGGTCCAGGAAACTATTGAGCAGCAACAGAAGATCAGAGCAGAGATGTGGCTAAACAGTAGCAGGTATGAAAAGACTTAGAGGTTCTGGT
TTCTGTAAGCTTCAAATATCTGTGATGCTTGTGCCAAAACAGCTTAAGTAGACTGTATTGTTTGAGAGTTAGTATCGAGAACAAGGGAAG
AACTGGTTTCACTCTGCACTTCTGATCTTTACAACAGGGCAATTGAAGGAACAGACTAAAAATCGTGTCCTGGAAGGAAACTACAGGTAC
TACCAGGGATTTTCAGTCTGAAGAAGAAAAGACAAAATAGATGACAGAAGGAGTATTAGAAGGGAGAGCGATGAGACTCAGTTGGACACC
GAGAGAGCAAAGAAGCAATAATACGTGAAGATGAAAATGAAATCAATTTCAGCATAAGAAGACAAGAACTTATGGTAAAGCTGCCCACAG
CCAGAAGAGGATCCTAGAAGGACAGGAATTCCCTGTCTGCAGCATTTCATAAGCATGTAATATTGTTGCAGGGATACTGCAGAAGGAGTT
GAAGCAGTGGACAGACAGATGATATAGGTGATTTTACAGCCTAAGAAAGCCCTGTGCTTGTGCCCCCAAAACATGAGGTGCTAGTGAATG
AATGCTGGGGGAAAGCCCAGGGCCTAGGTGTTGCAATGTTCTGTGGTTGGCAGATGCTTTTTGTTTTGTTAAAAAGTGCAACAGATAAAA
TTTATCAATACTTTTCTGCTACTCAGGAAA

>6128_6128_1_ARHGAP44-ZSWIM7_ARHGAP44_chr17_12832363_ENST00000262444_ZSWIM7_chr17_15884458_ENST00000399277_length(amino acids)=267AA_BP=194
MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTL
LGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR
EEMEEAANRVEICRVLGSSSKTYTCLASCHYCSCPAFAFSVLRKSDSILCKHLLAVYLSQVMRTCQQLSVSDKQLTDILLMEKKQEA

--------------------------------------------------------------
>6128_6128_2_ARHGAP44-ZSWIM7_ARHGAP44_chr17_12832363_ENST00000340825_ZSWIM7_chr17_15884458_ENST00000399277_length(transcript)=2591nt_BP=882nt
GACTGGGAGCAGGCAGCCCGGGCGGAGCGGGCCGGTGCCGAGGACGGCCCCAGGCATTGCTCTGCCCCGGGCATTGCGCGGCGCGCGTGA
GGGGGATGCGGCAGGAGGCGGCGCGGCGGGAGGAGTAGGCGGCGGCGCCCTCGGGAGGGAGCTGCGCGCGGGCCAGACGGCGCCCGGAGG
CTCCGCAGTGCCGCCGCCGTCGCCCGGGAGGCTCCGCGCGGGAGCCATGTAACCCTGCGGCGGGCTCCGGGCTGCTCCGTCCTTCCCCAG
CTCCCGGGCTAGCGCGGCAGCGGGGCCACGATGAAGAAGCAGTTCAATCGCATGCGCCAGCTGGCCAACCAGACGGTGGGCAGGGCTGAA
AAGACAGAAGTTTTGAGTGAAGACCTTCTTCAGGTGGAGAAGCGTCTGGAGCTGGTGAAACAGGTGTCCCACAGCACGCACAAGAAGCTC
ACCGCATGTCTGCAGGGCCAGCAAGGGGCAGAGGCTGACAAGCGCTCCAAAAAGTTGCCTTTGACAACACTGGCTCAGTGTCTGATGGAG
GGGTCAGCTATCCTGGGAGATGACACACTTCTTGGGAAGATGCTGAAACTCTGTGGAGAGACGGAGGACAAGCTGGCTCAGGAGCTGATA
CATTTTGAGTTGCAAGTAGAGAGAGACGTGATTGAGCCCCTGTTTTTGCTGGCGGAGGTGGAAATCCCAAATATTCAAAAGCAGAGGAAA
CACTTAGCCAAGTTGGTGCTGGACATGGATTCCTCACGAACCAGGTGGCAGCAGACTTCCAAGTCTTCAGGTTTGTCCAGCAGCTTACAG
CCTGCGGGTGCCAAGGCTGATGCCCTCAGGGAAGAAATGGAAGAGGCTGCCAACAGAGTGGAGATTTGCAGGGTCCTTGGAAGTTCCAGT
AAAACATACACATGTTTGGCTTCTTGTCATTACTGTTCATGTCCTGCATTTGCATTCTCAGTGCTACGGAAGAGTGACAGCATCCTGTGC
AAGCATCTCTTGGCAGTTTACCTGAGTCAGGTTATGAGGACCTGTCAGCAGCTAAGTGTCTCTGACAAGCAGTTGACTGACATATTATTG
ATGGAGAAGAAACAAGAAGCATAAAAGGTACAGATTGAGCATCATTCTTTCAAAATAGAATCCTGTCAAGAAATGCATTGAAAGCGTCAT
GATTCACATGGAAAAGAGGTGAAATGGATCTTCAGACACTTCATGTTACTGTCCCTTTTCCCTCCAGGACTGCAGGAGGTGCTGTGGGTT
GGAGCCGTGGGCTGTGGAGGGTTTGTGTATGATGAGAAGCCCTGTACAGTCTTGTCAAGAAATACCCTGAGCCAGTCTCTGAGACGCTTC
GGTAAAAAATGTCCCTGGATGGAATCAAGATTTTAAATTCAAATAAAGCCTAATATCATGTTGTGTCCACATTATTTAGTCTTTTTTTTT
TTCTTTTGAGATGGAGTCTCACTTTGTCGCCCAGGCTGGGGTGCAGTGGCGTGATCTCAGCTCACTGCAAGCTCCGCCTCCCGGGTTCAC
GCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTACCCGCCACCATGCCCGGCTAAATTTTTGTATTTTTTTTTTAGTAG
AGATGGGGTTTCACCGTGTTAGCCAGGATGGTCTCCATCTCCTGACCTAGTGGTCTGCCCGCCTCGACCTCCCAAAGTGCTGGAATTACA
TGCATGAGCCACTGCGCCTGACCCTATTTAGTCTTAAGTAACTAACTGAATTACTAGTAATTTTTAAAAGGTTGGAATGGTGGGCCAAAC
AGTAAGATGAAGTTTCGACGAGTAGGTCAGTTCTTTTCCTTGGGTCCAGGAAACTATTGAGCAGCAACAGAAGATCAGAGCAGAGATGTG
GCTAAACAGTAGCAGGTATGAAAAGACTTAGAGGTTCTGGTTTCTGTAAGCTTCAAATATCTGTGATGCTTGTGCCAAAACAGCTTAAGT
AGACTGTATTGTTTGAGAGTTAGTATCGAGAACAAGGGAAGAACTGGTTTCACTCTGCACTTCTGATCTTTACAACAGGGCAATTGAAGG
AACAGACTAAAAATCGTGTCCTGGAAGGAAACTACAGGTACTACCAGGGATTTTCAGTCTGAAGAAGAAAAGACAAAATAGATGACAGAA
GGAGTATTAGAAGGGAGAGCGATGAGACTCAGTTGGACACCGAGAGAGCAAAGAAGCAATAATACGTGAAGATGAAAATGAAATCAATTT
CAGCATAAGAAGACAAGAACTTATGGTAAAGCTGCCCACAGCCAGAAGAGGATCCTAGAAGGACAGGAATTCCCTGTCTGCAGCATTTCA
TAAGCATGTAATATTGTTGCAGGGATACTGCAGAAGGAGTTGAAGCAGTGGACAGACAGATGATATAGGTGATTTTACAGCCTAAGAAAG
CCCTGTGCTTGTGCCCCCAAAACATGAGGTGCTAGTGAATGAATGCTGGGGGAAAGCCCAGGGCCTAGGTGTTGCAATGTTCTGTGGTTG
GCAGATGCTTTTTGTTTTGTTAAAAAGTGCAACAGATAAAATTTATCAATACTTTTCTGCTACTCAGGAAA

>6128_6128_2_ARHGAP44-ZSWIM7_ARHGAP44_chr17_12832363_ENST00000340825_ZSWIM7_chr17_15884458_ENST00000399277_length(amino acids)=267AA_BP=194
MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTL
LGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR
EEMEEAANRVEICRVLGSSSKTYTCLASCHYCSCPAFAFSVLRKSDSILCKHLLAVYLSQVMRTCQQLSVSDKQLTDILLMEKKQEA

--------------------------------------------------------------
>6128_6128_3_ARHGAP44-ZSWIM7_ARHGAP44_chr17_12832363_ENST00000379672_ZSWIM7_chr17_15884458_ENST00000399277_length(transcript)=2591nt_BP=882nt
GACTGGGAGCAGGCAGCCCGGGCGGAGCGGGCCGGTGCCGAGGACGGCCCCAGGCATTGCTCTGCCCCGGGCATTGCGCGGCGCGCGTGA
GGGGGATGCGGCAGGAGGCGGCGCGGCGGGAGGAGTAGGCGGCGGCGCCCTCGGGAGGGAGCTGCGCGCGGGCCAGACGGCGCCCGGAGG
CTCCGCAGTGCCGCCGCCGTCGCCCGGGAGGCTCCGCGCGGGAGCCATGTAACCCTGCGGCGGGCTCCGGGCTGCTCCGTCCTTCCCCAG
CTCCCGGGCTAGCGCGGCAGCGGGGCCACGATGAAGAAGCAGTTCAATCGCATGCGCCAGCTGGCCAACCAGACGGTGGGCAGGGCTGAA
AAGACAGAAGTTTTGAGTGAAGACCTTCTTCAGGTGGAGAAGCGTCTGGAGCTGGTGAAACAGGTGTCCCACAGCACGCACAAGAAGCTC
ACCGCATGTCTGCAGGGCCAGCAAGGGGCAGAGGCTGACAAGCGCTCCAAAAAGTTGCCTTTGACAACACTGGCTCAGTGTCTGATGGAG
GGGTCAGCTATCCTGGGAGATGACACACTTCTTGGGAAGATGCTGAAACTCTGTGGAGAGACGGAGGACAAGCTGGCTCAGGAGCTGATA
CATTTTGAGTTGCAAGTAGAGAGAGACGTGATTGAGCCCCTGTTTTTGCTGGCGGAGGTGGAAATCCCAAATATTCAAAAGCAGAGGAAA
CACTTAGCCAAGTTGGTGCTGGACATGGATTCCTCACGAACCAGGTGGCAGCAGACTTCCAAGTCTTCAGGTTTGTCCAGCAGCTTACAG
CCTGCGGGTGCCAAGGCTGATGCCCTCAGGGAAGAAATGGAAGAGGCTGCCAACAGAGTGGAGATTTGCAGGGTCCTTGGAAGTTCCAGT
AAAACATACACATGTTTGGCTTCTTGTCATTACTGTTCATGTCCTGCATTTGCATTCTCAGTGCTACGGAAGAGTGACAGCATCCTGTGC
AAGCATCTCTTGGCAGTTTACCTGAGTCAGGTTATGAGGACCTGTCAGCAGCTAAGTGTCTCTGACAAGCAGTTGACTGACATATTATTG
ATGGAGAAGAAACAAGAAGCATAAAAGGTACAGATTGAGCATCATTCTTTCAAAATAGAATCCTGTCAAGAAATGCATTGAAAGCGTCAT
GATTCACATGGAAAAGAGGTGAAATGGATCTTCAGACACTTCATGTTACTGTCCCTTTTCCCTCCAGGACTGCAGGAGGTGCTGTGGGTT
GGAGCCGTGGGCTGTGGAGGGTTTGTGTATGATGAGAAGCCCTGTACAGTCTTGTCAAGAAATACCCTGAGCCAGTCTCTGAGACGCTTC
GGTAAAAAATGTCCCTGGATGGAATCAAGATTTTAAATTCAAATAAAGCCTAATATCATGTTGTGTCCACATTATTTAGTCTTTTTTTTT
TTCTTTTGAGATGGAGTCTCACTTTGTCGCCCAGGCTGGGGTGCAGTGGCGTGATCTCAGCTCACTGCAAGCTCCGCCTCCCGGGTTCAC
GCCATTCTCCTGCCTCAGCCTCCCGAGTAGCTGGGACTACAGGTACCCGCCACCATGCCCGGCTAAATTTTTGTATTTTTTTTTTAGTAG
AGATGGGGTTTCACCGTGTTAGCCAGGATGGTCTCCATCTCCTGACCTAGTGGTCTGCCCGCCTCGACCTCCCAAAGTGCTGGAATTACA
TGCATGAGCCACTGCGCCTGACCCTATTTAGTCTTAAGTAACTAACTGAATTACTAGTAATTTTTAAAAGGTTGGAATGGTGGGCCAAAC
AGTAAGATGAAGTTTCGACGAGTAGGTCAGTTCTTTTCCTTGGGTCCAGGAAACTATTGAGCAGCAACAGAAGATCAGAGCAGAGATGTG
GCTAAACAGTAGCAGGTATGAAAAGACTTAGAGGTTCTGGTTTCTGTAAGCTTCAAATATCTGTGATGCTTGTGCCAAAACAGCTTAAGT
AGACTGTATTGTTTGAGAGTTAGTATCGAGAACAAGGGAAGAACTGGTTTCACTCTGCACTTCTGATCTTTACAACAGGGCAATTGAAGG
AACAGACTAAAAATCGTGTCCTGGAAGGAAACTACAGGTACTACCAGGGATTTTCAGTCTGAAGAAGAAAAGACAAAATAGATGACAGAA
GGAGTATTAGAAGGGAGAGCGATGAGACTCAGTTGGACACCGAGAGAGCAAAGAAGCAATAATACGTGAAGATGAAAATGAAATCAATTT
CAGCATAAGAAGACAAGAACTTATGGTAAAGCTGCCCACAGCCAGAAGAGGATCCTAGAAGGACAGGAATTCCCTGTCTGCAGCATTTCA
TAAGCATGTAATATTGTTGCAGGGATACTGCAGAAGGAGTTGAAGCAGTGGACAGACAGATGATATAGGTGATTTTACAGCCTAAGAAAG
CCCTGTGCTTGTGCCCCCAAAACATGAGGTGCTAGTGAATGAATGCTGGGGGAAAGCCCAGGGCCTAGGTGTTGCAATGTTCTGTGGTTG
GCAGATGCTTTTTGTTTTGTTAAAAAGTGCAACAGATAAAATTTATCAATACTTTTCTGCTACTCAGGAAA

>6128_6128_3_ARHGAP44-ZSWIM7_ARHGAP44_chr17_12832363_ENST00000379672_ZSWIM7_chr17_15884458_ENST00000399277_length(amino acids)=267AA_BP=194
MKKQFNRMRQLANQTVGRAEKTEVLSEDLLQVEKRLELVKQVSHSTHKKLTACLQGQQGAEADKRSKKLPLTTLAQCLMEGSAILGDDTL
LGKMLKLCGETEDKLAQELIHFELQVERDVIEPLFLLAEVEIPNIQKQRKHLAKLVLDMDSSRTRWQQTSKSSGLSSSLQPAGAKADALR
EEMEEAANRVEICRVLGSSSKTYTCLASCHYCSCPAFAFSVLRKSDSILCKHLLAVYLSQVMRTCQQLSVSDKQLTDILLMEKKQEA

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Fusion Gene PPI Analysis for ARHGAP44-ZSWIM7


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneARHGAP44chr17:12832363chr17:15884458ENST00000379672+721731_818194.0819.0BST2


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for ARHGAP44-ZSWIM7


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for ARHGAP44-ZSWIM7


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource