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	Fusion Gene Summary
	Fusion Gene ORF analysis
	Fusion Genomic Features
	Fusion Protein Features
	Fusion Gene Sequence
	Fusion Gene PPI analysis
	Related Drugs
	Related Diseases

Fusion gene:CDC27-HLF (FusionGDB2 ID:HG996TG3131)

Fusion Gene Summary for CDC27-HLF

Fusion gene summary

Fusion gene information	Fusion gene name: CDC27-HLF
	Fusion gene ID: hg996tg3131
		Hgene	Tgene
	Gene symbol	CDC27	HLF
	Gene ID	996	3131
	Gene name	cell division cycle 27	HLF transcription factor, PAR bZIP family member
	Synonyms	ANAPC3\|APC3\|CDC27Hs\|D0S1430E\|D17S978E\|H-NUC\|HNUC\|NUC2	-
	Cytomap	('CDC27')('HLF') 17q21.32	17q22
	Type of gene	protein-coding	protein-coding
	Description	cell division cycle protein 27 homologD0S1430E, D17S978Eanaphase promoting complex subunit 3anaphase-promoting complex, protein 3cell division cycle 27 homolognuc2 homolog	hepatic leukemia factorHLF, PAR bZIP transcription factorPAR bZIP transcription factor
	Modification date	20200313	20200313
	UniProtAcc	.	Q16534
	Ensembl transtripts involved in fusion gene	ENST00000066544, ENST00000446365, ENST00000527547, ENST00000531206, ENST00000528748,
Fusion gene scores	* DoF score	12 X 8 X 10=960	1 X 1 X 1=1
	# samples	16	1
	** MAII score	log2(16/960*10)=-2.58496250072116 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(1/1*10)=3.32192809488736
Context	PubMed: CDC27 [Title/Abstract] AND HLF [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint	CDC27(45258928)-HLF(53345112), # samples:1
Anticipated loss of major functional domain due to fusion event.	CDC27-HLF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CDC27-HLF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CDC27-HLF seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. CDC27-HLF seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. CDC27-HLF seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	CDC27	GO:0070979	protein K11-linked ubiquitination	18485873
Tgene	HLF	GO:0045944	positive regulation of transcription by RNA polymerase II	8065331

Fusion gene breakpoints across CDC27 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across HLF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-52-7810-01A	CDC27	chr17	45258928	-	HLF	chr17	53345112	+

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Fusion Gene ORF analysis for CDC27-HLF

Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

ORF	Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
5CDS-5UTR	ENST00000066544	ENST00000430986	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
5CDS-5UTR	ENST00000066544	ENST00000573945	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
5CDS-5UTR	ENST00000066544	ENST00000575345	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
5CDS-5UTR	ENST00000446365	ENST00000430986	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
5CDS-5UTR	ENST00000446365	ENST00000573945	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
5CDS-5UTR	ENST00000446365	ENST00000575345	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
5CDS-5UTR	ENST00000527547	ENST00000430986	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
5CDS-5UTR	ENST00000527547	ENST00000573945	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
5CDS-5UTR	ENST00000527547	ENST00000575345	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
5CDS-5UTR	ENST00000531206	ENST00000430986	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
5CDS-5UTR	ENST00000531206	ENST00000573945	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
5CDS-5UTR	ENST00000531206	ENST00000575345	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
5CDS-intron	ENST00000066544	ENST00000575307	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
5CDS-intron	ENST00000446365	ENST00000575307	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
5CDS-intron	ENST00000527547	ENST00000575307	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
5CDS-intron	ENST00000531206	ENST00000575307	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
5UTR-3CDS	ENST00000528748	ENST00000226067	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
5UTR-5UTR	ENST00000528748	ENST00000430986	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
5UTR-5UTR	ENST00000528748	ENST00000573945	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
5UTR-5UTR	ENST00000528748	ENST00000575345	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
5UTR-intron	ENST00000528748	ENST00000575307	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
Frame-shift	ENST00000446365	ENST00000226067	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
In-frame	ENST00000066544	ENST00000226067	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
In-frame	ENST00000527547	ENST00000226067	CDC27	chr17	45258928	-	HLF	chr17	53345112	+
In-frame	ENST00000531206	ENST00000226067	CDC27	chr17	45258928	-	HLF	chr17	53345112	+

ORFfinder result based on the fusion transcript sequence of in-frame fusion genes.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000066544	CDC27	chr17	45258928	-	ENST00000226067	HLF	chr17	53345112	+	5156	197	94	969	291
ENST00000531206	CDC27	chr17	45258928	-	ENST00000226067	HLF	chr17	53345112	+	5066	107	4	879	291
ENST00000527547	CDC27	chr17	45258928	-	ENST00000226067	HLF	chr17	53345112	+	5114	155	52	927	291

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000066544	ENST00000226067	CDC27	chr17	45258928	-	HLF	chr17	53345112	+	0.0003286	0.99967146
ENST00000531206	ENST00000226067	CDC27	chr17	45258928	-	HLF	chr17	53345112	+	0.000302491	0.99969757
ENST00000527547	ENST00000226067	CDC27	chr17	45258928	-	HLF	chr17	53345112	+	0.000315924	0.9996841

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Fusion Genomic Features for CDC27-HLF

FusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.

Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	1-p	p (fusion gene breakpoint)
CDC27	chr17	45258927	-	HLF	chr17	53345111	+	0.000376666	0.9996233
CDC27	chr17	45258927	-	HLF	chr17	53345111	+	0.000376666	0.9996233

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.

Distribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.

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Fusion Protein Features for CDC27-HLF

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:45258928/chr17:53345112)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	HLF Q16534
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page

* Minus value of BPloci means that the break pointn is located before the CDS.

- In-frame and retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000066544

6_35

825.0

Repeat

Note=TPR 1

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000531206

6_35

831.0

Repeat

Note=TPR 1

Tgene

HLF

chr17:45258928

chr17:53345112

ENST00000226067

158_209

296.0

Compositional bias

Note=Pro-rich (proline/acidic region (PAR))

Tgene

HLF

chr17:45258928

chr17:53345112

ENST00000226067

225_288

296.0

Domain

bZIP

Tgene

HLF

chr17:45258928

chr17:53345112

ENST00000226067

227_247

296.0

Region

Basic motif

Tgene

HLF

chr17:45258928

chr17:53345112

ENST00000226067

248_255

296.0

Region

Leucine-zipper

- In-frame and not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000066544

115_145

825.0

Repeat

Note=TPR 4

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000066544

38_65

825.0

Repeat

Note=TPR 2

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000066544

465_495

825.0

Repeat

Note=TPR 5

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000066544

499_528

825.0

Repeat

Note=TPR 6

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000066544

533_563

825.0

Repeat

Note=TPR 7

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000066544

567_598

825.0

Repeat

Note=TPR 8

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000066544

601_631

825.0

Repeat

Note=TPR 9

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000066544

635_667

825.0

Repeat

Note=TPR 10

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000066544

670_702

825.0

Repeat

Note=TPR 11

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000066544

67_99

825.0

Repeat

Note=TPR 3

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000066544

704_734

825.0

Repeat

Note=TPR 12

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000066544

737_768

825.0

Repeat

Note=TPR 13

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000531206

115_145

831.0

Repeat

Note=TPR 4

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000531206

38_65

831.0

Repeat

Note=TPR 2

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000531206

465_495

831.0

Repeat

Note=TPR 5

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000531206

499_528

831.0

Repeat

Note=TPR 6

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000531206

533_563

831.0

Repeat

Note=TPR 7

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000531206

567_598

831.0

Repeat

Note=TPR 8

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000531206

601_631

831.0

Repeat

Note=TPR 9

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000531206

635_667

831.0

Repeat

Note=TPR 10

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000531206

670_702

831.0

Repeat

Note=TPR 11

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000531206

67_99

831.0

Repeat

Note=TPR 3

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000531206

704_734

831.0

Repeat

Note=TPR 12

Hgene

CDC27

chr17:45258928

chr17:53345112

ENST00000531206

737_768

831.0

Repeat

Note=TPR 13

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Fusion Gene Sequence for CDC27-HLF

For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>14805_14805_1_CDC27-HLF_CDC27_chr17_45258928_ENST00000066544_HLF_chr17_53345112_ENST00000226067_length(transcript)=5156nt_BP=197nt
TCGCTGGTGAGTTTAAATGAGCAGGGGCTGGCCGGGCCGGAGCCGCTACAGGGGGGGCCTGAGGCACTGCAGAAAGTGGGCCTGAGCCTC
GAGGATGACGGTGCTGCAGGAACCCGTCCAGGCTGCTATATGGCAAGCACTAAACCACTATGCTTACCGAGATGCGGTTTTCCTCGCAGA
ACGCCTTTATGCAGAAGCATTTAGTAAAGATAAAGACAAGGAAAAGAAGCTGGATGATGAGAGTAACAGCCCGACGGTCCCCCAGTCGGC
ATTCCTGGGGCCTACCTTATGGGACAAAACCCTTCCCTATGACGGAGATACTTTCCAGTTGGAATACATGGACCTGGAGGAGTTTTTGTC
AGAAAATGGCATTCCCCCCAGCCCATCTCAGCATGACCACAGCCCTCACCCTCCTGGGCTGCAGCCAGCTTCCTCGGCTGCCCCCTCGGT
CATGGACCTCAGCAGCCGGGCCTCTGCACCCCTTCACCCTGGCATCCCATCTCCGAACTGTATGCAGAGCCCCATCAGACCAGGTCAGCT
GTTGCCAGCAAACCGCAATACACCAAGTCCCATTGATCCTGACACCATCCAGGTCCCAGTGGGTTATGAGCCAGACCCAGCAGATCTTGC
CCTTTCCAGCATCCCTGGCCAGGAAATGTTTGACCCTCGCAAACGCAAGTTCTCTGAGGAAGAACTGAAGCCACAGCCCATGATCAAGAA
AGCTCGCAAAGTCTTCATCCCTGATGACCTGAAGGATGACAAGTACTGGGCAAGGCGCAGAAAGAACAACATGGCAGCCAAGCGCTCCCG
CGACGCCCGGAGGCTGAAAGAGAACCAGATCGCCATCCGGGCCTCGTTCCTGGAGAAGGAGAACTCGGCCCTCCGCCAGGAGGTGGCTGA
CTTGAGGAAGGAGCTGGGCAAATGCAAGAACATACTTGCCAAGTATGAGGCCAGGCACGGGCCCCTGTAGGATGGCATTTTTGCAGGCTG
GCTTTGGAATAGATGGACAGTTTGTTTCCTGTCTGATAGCACCACACGCAAACCAACCTTTCTGACATCAGCACTTTACCAGAGGCATAA
ACACAACTGACTCCCATTTTGGTGTGCATCTGTGTGTGTGTGCGTGTATATGTGCTTGTGCTCATGTGTGTGGTCAGCGGTATGTGCGTG
TGCGTGTTCCTTTGCTCTTGCCATTTTAAGGTAGCCCTCTCATCGTCTTTTAGTTCCAACAAAGAAAGGTGCCATGTCTTTACTAGACTG
AGGAGCCCTCTCGCGGGTCTCCCATCCCCTCCCTCCTTCACTCCTGCCTCCTCAGCTTTGCTTCATGTTCGAGCTTACCTACTCTTCCAG
GACTCTCTGCTTGGATTCACTAAAAAGGGCCCTGGTAAAATAGTGGATCTCAGTTTTTAAGAGTACAAGCTCTTGTTTCTGTTTAGTCCG
TAAGTTACCATGCTAATGAGGTGCACACAATAACTTAGCACTACTCCGCAGCTCTAGTCCTTTATAAGTTGCTTTCCTCTTACTTTCAGT
TTTGGTGATAATCGTCTTCAAATTAAAGTGCTGTTTAGATTTATTAGATCCCATATTTACTTACTGCTATCTACTAAGTTTCCTTTTAAT
TCTACCAACCCCAGATAAGTAAGAGTACTATTAATAGAACACAGAGTGTGTTTTTGCACTGTCTGTACCTAAAGCAATAATCCTATTGTA
CGCTAGAGCATGCTGCCTGAGTATTACTAGTGGACGTAGGATATTTTCCCTACCTAAGAATTTCACTGTCTTTTAAAAAACAAAAAGTAA
AGTAATGCATTTGAGCATGGCCAGACTATTCCCTAGGACAAGGAAGCAGAGGGAAATGGGAGGTCTAAGGATGAGGGGTTAATTTATCAG
TACATGAGCCAAAAACTGCGTCTTGGATTAGCCTTTGACATTGATGTGTTCGGTTTTGTTGTTCCCCTTCCCTCACACCCTGCCTCGCCC
CCACTTTTCTAGTTAACTTTTTCCATATCCCTCTTGACATTCAAAACAGTTACTTAAGATTCAGTTTTCCCACTTTTTGGTAATATATAT
ATTTTTGTGAATTATACTTTGTTGTTTTTAAAAAGAAAATCAGTTGATTAAGTTAATAAGTTGATGTTTTCTAAGGCCCTTTTTCCTAGT
GGTGTCATTTTTGAATGCCTCATAAATTAATGATTCTGAAGCTTATGTTTCTTATTCTCTGTTTGCTTTTGAACGTATGTGCTCTTATAA
AGTGGACTTCTGAAAAATGAATGTAAAAGACACTGGTGTATCTCAGAAGGGGATGGTGTTGTCACAAACTGTGGTTAATCCAATCAATTT
AAATGTTTACTATAGACCAAAAGGAGAGATTATTAAATCGTTTAATGTTTATACAGAGTAATTATAGGAAGTTCTTTTTTGTACAGTATT
TTTCAGATATAAATACTGACAATGTATTTTGGAAGACATATATTATATATAGAAAAGAGGAGAGGAAAACTATTCCATGTTTTAAAATTA
TATAGCAAAGATATATATTCACCAATGTTGTACAGAGAAGAAGTGCTTGGGGGTTTTTGAAGTCTTTAATATTTTAAGCCCTATCACTGA
CACATCAGCATGTTTTCTGCTTTAAATTAAAATTTTATGACAGTATCGAGGCTTGTGATGACGAATCCTGCTCTAAAATACACAAGGAGC
TTTCTTGTTTCTTATTAGGCCTCAGAAAGAAGTCAGTTAACGTCACCCAAAAGCACAAAATGGATTTTAGTCAAATATTTATTGGATGAT
ACAGTGTTTTTTAGGAAAAGCATCTGCCACAAAAATGTTCACTTCGAAATTCTGAGTTCCTGGAATGGCACGTTGCTGCCAGTGCCCCAG
ACAGTTCTTTTCTACCCTGCGGGCCCGCACGTTTTATGAGGTTGATATCGGTGCTATGTGTTTGGTTTATAATTTGATAGATGTTTGACT
TTAAAGATGATTGTTCTTTTGTTTCATTAAGTTGTAAAATGTCAAGAAATTCTGCTGTTACGACAAAGAAACATTTTACGCTAGATTAAA
ATATCCTTTCATCAATGGGATTTTCTAGTTTCCTGCCTTCAGAGTATCTAATCCTTTAATGATCTGGTGGTCTCCTCGTCAATCCATCAG
CAATGCTTCTCTCATAGTGTCATAGACTTGGGAAACCCAACCAGTAGGATATTTCTACAAGGTGTTCATTTTGTCACAAGCTGTAGATAA
CAGCAAGAGATGGGGGTGTATTGGAATTGCAATACATTGTTCAGGTGAATAATAAAATCAAAAACTTTTGCAATCTTAAGCAGAGATAAA
TAAAAGATAGCAATATGAGACACAGGTGGACGTAGAGTTGGCCTTTTTACAGGCAAAGAGGCGAATTGTAGAATTGTTAGATGGCAATAG
TCATTAAAAACATAGAAAAATGATGTCTTTAAGTGGAGAATTGTGGAAGGATTGTAACATGGACCATCCAAATTTATGGCCGTATCAAAT
GGTAGCTGAAAAAACTATATTTGAGCACTGGTCTCTCTTGGAATTAGATGTTTATATCAAATGAGCATCTCAAATGTTTTCTGCAGAAAA
AAATAAAAAGATTCTAATAAAATGTATTCTCTTGTGTGCCAGGAGAGGTTTCAGAAACCTACCTCGTCTTACAAATTTAAACACTTTGGA
GTCTGTACAGGTGCCTTATATGTAGGTCATTGTCACGATACACACACACGAACACTCCCTCTGGACTGGCTGCCTCTCCATCCAGGGCAG
TTAACTAGCAAACAAGGCAGATCTGCTTCATGGAGCGGGAGGCCATGGCTTGACTCTGAGTGATTTGGGTCAACCGGAGTCAGACGCATG
TCTGCACGCTGCAGCTATTATGAGAGTCCCTTTGTCATTTTTCACCTTTTCATCCTAAGCATCTTTCAGAGATTAATTATTTGGCCATTA
ACAATGAATCCAAATCATATCATACTGACATCATCTAGACATGATTTGGAAGGAACAGCTTAGGACCTCCTGATGAGGTCACATTGTTGT
TTCTTTTAACTAGACTTGGCAAAGAAAGGCAAAAATTGACCAGCCTATCTTTCTGCTGGTGCTGCCTTAAGGAGGTAGTTTGTTGAGGGG
AGGGCTGTAGATCATTACTTCTTTCTCTTCAGGAAGTGGCCACTTTGAACCATTCAAATACCACATTAGGCAAGACTGTGATAGGCCTTT
TGTCTTCAAATACAACAGGCCTCCACTGACCCATCCCTCAAAGCAGAAGGACCCTTTGAGGAGAGTACAGATGGGATTCCACAGTGGGGT
GGGTGGAATGGAAACCTGTACTAGACCACCCAGAGGTTCCTTCTAACCCACTGGTTTGGTGGGGAACTCACAGTAATTCCAAATGTACAA
TCAGATGTCTAGGGTCTGTTTTCGGAAGAAGCAAGAATTATCAGTGGCACCCTCCCCACTGCCCCCAGTGTAAAACAATAGACATTCTGT
GAAATGCAAAGCTATTCTTTGGTTTTTCTAGTAGTTTATCTCATTTTACCCTATTCTTCCTTTAAGGAAAACTCAATCTTTATCACAGTC
AATTAGAGCGATCCCAAGGCATGGGACCAGGCCTGCTTGCCTATGTGTGATGGCAATTGGAGATCTGGATTTAGCACTGGGGTCTCAGCA
CCCTGCAGGTGTCTGAGACTAAGTGATCTGCCCTCCAGGTGGCGATCACCTTCTGCTCCTAGGTACCCCCACTGGCAAGGCCAAGGTCTC
CTCCACGTTTTTTCTGCAATTAATAATGTCATTTAAAAAATGAGCAAAGCCTTATCCGAATCGGATATAGCAACTAAAGTCAATACATTT
TGCAGGAGGCTAAGTGTAAGAGTGTGTGTGTGTGTGTGTGCGTGCATGTGTGTGTGTGTGTATGTGTGTGAATAAGTCGACATAAAGTCT
TTAATTTTGAGCACCTTACCAAACATAACAATAATCCATTATCCTTTTGGCAACACCACAAAGATCGCATCTGTTAAACAGGTACAAGTT
GACATGAGGTTAGTTTAATTGTACACCATGATATTGGTGGTATTTATGCTGTTAAGTCCAAACCTTTATCTGTCTGTTATTCTTAATGTT
GAATAAACTTTGAATTTTTTCCTTTC

>14805_14805_1_CDC27-HLF_CDC27_chr17_45258928_ENST00000066544_HLF_chr17_53345112_ENST00000226067_length(amino acids)=291AA_BP=34
MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEAFSKDKDKEKKLDDESNSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSE
NGIPPSPSQHDHSPHPPGLQPASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLAL
SSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADL
RKELGKCKNILAKYEARHGPL

--------------------------------------------------------------
>14805_14805_2_CDC27-HLF_CDC27_chr17_45258928_ENST00000527547_HLF_chr17_53345112_ENST00000226067_length(transcript)=5114nt_BP=155nt
CCGCTACAGGGGGGGCCTGAGGCACTGCAGAAAGTGGGCCTGAGCCTCGAGGATGACGGTGCTGCAGGAACCCGTCCAGGCTGCTATATG
GCAAGCACTAAACCACTATGCTTACCGAGATGCGGTTTTCCTCGCAGAACGCCTTTATGCAGAAGCATTTAGTAAAGATAAAGACAAGGA
AAAGAAGCTGGATGATGAGAGTAACAGCCCGACGGTCCCCCAGTCGGCATTCCTGGGGCCTACCTTATGGGACAAAACCCTTCCCTATGA
CGGAGATACTTTCCAGTTGGAATACATGGACCTGGAGGAGTTTTTGTCAGAAAATGGCATTCCCCCCAGCCCATCTCAGCATGACCACAG
CCCTCACCCTCCTGGGCTGCAGCCAGCTTCCTCGGCTGCCCCCTCGGTCATGGACCTCAGCAGCCGGGCCTCTGCACCCCTTCACCCTGG
CATCCCATCTCCGAACTGTATGCAGAGCCCCATCAGACCAGGTCAGCTGTTGCCAGCAAACCGCAATACACCAAGTCCCATTGATCCTGA
CACCATCCAGGTCCCAGTGGGTTATGAGCCAGACCCAGCAGATCTTGCCCTTTCCAGCATCCCTGGCCAGGAAATGTTTGACCCTCGCAA
ACGCAAGTTCTCTGAGGAAGAACTGAAGCCACAGCCCATGATCAAGAAAGCTCGCAAAGTCTTCATCCCTGATGACCTGAAGGATGACAA
GTACTGGGCAAGGCGCAGAAAGAACAACATGGCAGCCAAGCGCTCCCGCGACGCCCGGAGGCTGAAAGAGAACCAGATCGCCATCCGGGC
CTCGTTCCTGGAGAAGGAGAACTCGGCCCTCCGCCAGGAGGTGGCTGACTTGAGGAAGGAGCTGGGCAAATGCAAGAACATACTTGCCAA
GTATGAGGCCAGGCACGGGCCCCTGTAGGATGGCATTTTTGCAGGCTGGCTTTGGAATAGATGGACAGTTTGTTTCCTGTCTGATAGCAC
CACACGCAAACCAACCTTTCTGACATCAGCACTTTACCAGAGGCATAAACACAACTGACTCCCATTTTGGTGTGCATCTGTGTGTGTGTG
CGTGTATATGTGCTTGTGCTCATGTGTGTGGTCAGCGGTATGTGCGTGTGCGTGTTCCTTTGCTCTTGCCATTTTAAGGTAGCCCTCTCA
TCGTCTTTTAGTTCCAACAAAGAAAGGTGCCATGTCTTTACTAGACTGAGGAGCCCTCTCGCGGGTCTCCCATCCCCTCCCTCCTTCACT
CCTGCCTCCTCAGCTTTGCTTCATGTTCGAGCTTACCTACTCTTCCAGGACTCTCTGCTTGGATTCACTAAAAAGGGCCCTGGTAAAATA
GTGGATCTCAGTTTTTAAGAGTACAAGCTCTTGTTTCTGTTTAGTCCGTAAGTTACCATGCTAATGAGGTGCACACAATAACTTAGCACT
ACTCCGCAGCTCTAGTCCTTTATAAGTTGCTTTCCTCTTACTTTCAGTTTTGGTGATAATCGTCTTCAAATTAAAGTGCTGTTTAGATTT
ATTAGATCCCATATTTACTTACTGCTATCTACTAAGTTTCCTTTTAATTCTACCAACCCCAGATAAGTAAGAGTACTATTAATAGAACAC
AGAGTGTGTTTTTGCACTGTCTGTACCTAAAGCAATAATCCTATTGTACGCTAGAGCATGCTGCCTGAGTATTACTAGTGGACGTAGGAT
ATTTTCCCTACCTAAGAATTTCACTGTCTTTTAAAAAACAAAAAGTAAAGTAATGCATTTGAGCATGGCCAGACTATTCCCTAGGACAAG
GAAGCAGAGGGAAATGGGAGGTCTAAGGATGAGGGGTTAATTTATCAGTACATGAGCCAAAAACTGCGTCTTGGATTAGCCTTTGACATT
GATGTGTTCGGTTTTGTTGTTCCCCTTCCCTCACACCCTGCCTCGCCCCCACTTTTCTAGTTAACTTTTTCCATATCCCTCTTGACATTC
AAAACAGTTACTTAAGATTCAGTTTTCCCACTTTTTGGTAATATATATATTTTTGTGAATTATACTTTGTTGTTTTTAAAAAGAAAATCA
GTTGATTAAGTTAATAAGTTGATGTTTTCTAAGGCCCTTTTTCCTAGTGGTGTCATTTTTGAATGCCTCATAAATTAATGATTCTGAAGC
TTATGTTTCTTATTCTCTGTTTGCTTTTGAACGTATGTGCTCTTATAAAGTGGACTTCTGAAAAATGAATGTAAAAGACACTGGTGTATC
TCAGAAGGGGATGGTGTTGTCACAAACTGTGGTTAATCCAATCAATTTAAATGTTTACTATAGACCAAAAGGAGAGATTATTAAATCGTT
TAATGTTTATACAGAGTAATTATAGGAAGTTCTTTTTTGTACAGTATTTTTCAGATATAAATACTGACAATGTATTTTGGAAGACATATA
TTATATATAGAAAAGAGGAGAGGAAAACTATTCCATGTTTTAAAATTATATAGCAAAGATATATATTCACCAATGTTGTACAGAGAAGAA
GTGCTTGGGGGTTTTTGAAGTCTTTAATATTTTAAGCCCTATCACTGACACATCAGCATGTTTTCTGCTTTAAATTAAAATTTTATGACA
GTATCGAGGCTTGTGATGACGAATCCTGCTCTAAAATACACAAGGAGCTTTCTTGTTTCTTATTAGGCCTCAGAAAGAAGTCAGTTAACG
TCACCCAAAAGCACAAAATGGATTTTAGTCAAATATTTATTGGATGATACAGTGTTTTTTAGGAAAAGCATCTGCCACAAAAATGTTCAC
TTCGAAATTCTGAGTTCCTGGAATGGCACGTTGCTGCCAGTGCCCCAGACAGTTCTTTTCTACCCTGCGGGCCCGCACGTTTTATGAGGT
TGATATCGGTGCTATGTGTTTGGTTTATAATTTGATAGATGTTTGACTTTAAAGATGATTGTTCTTTTGTTTCATTAAGTTGTAAAATGT
CAAGAAATTCTGCTGTTACGACAAAGAAACATTTTACGCTAGATTAAAATATCCTTTCATCAATGGGATTTTCTAGTTTCCTGCCTTCAG
AGTATCTAATCCTTTAATGATCTGGTGGTCTCCTCGTCAATCCATCAGCAATGCTTCTCTCATAGTGTCATAGACTTGGGAAACCCAACC
AGTAGGATATTTCTACAAGGTGTTCATTTTGTCACAAGCTGTAGATAACAGCAAGAGATGGGGGTGTATTGGAATTGCAATACATTGTTC
AGGTGAATAATAAAATCAAAAACTTTTGCAATCTTAAGCAGAGATAAATAAAAGATAGCAATATGAGACACAGGTGGACGTAGAGTTGGC
CTTTTTACAGGCAAAGAGGCGAATTGTAGAATTGTTAGATGGCAATAGTCATTAAAAACATAGAAAAATGATGTCTTTAAGTGGAGAATT
GTGGAAGGATTGTAACATGGACCATCCAAATTTATGGCCGTATCAAATGGTAGCTGAAAAAACTATATTTGAGCACTGGTCTCTCTTGGA
ATTAGATGTTTATATCAAATGAGCATCTCAAATGTTTTCTGCAGAAAAAAATAAAAAGATTCTAATAAAATGTATTCTCTTGTGTGCCAG
GAGAGGTTTCAGAAACCTACCTCGTCTTACAAATTTAAACACTTTGGAGTCTGTACAGGTGCCTTATATGTAGGTCATTGTCACGATACA
CACACACGAACACTCCCTCTGGACTGGCTGCCTCTCCATCCAGGGCAGTTAACTAGCAAACAAGGCAGATCTGCTTCATGGAGCGGGAGG
CCATGGCTTGACTCTGAGTGATTTGGGTCAACCGGAGTCAGACGCATGTCTGCACGCTGCAGCTATTATGAGAGTCCCTTTGTCATTTTT
CACCTTTTCATCCTAAGCATCTTTCAGAGATTAATTATTTGGCCATTAACAATGAATCCAAATCATATCATACTGACATCATCTAGACAT
GATTTGGAAGGAACAGCTTAGGACCTCCTGATGAGGTCACATTGTTGTTTCTTTTAACTAGACTTGGCAAAGAAAGGCAAAAATTGACCA
GCCTATCTTTCTGCTGGTGCTGCCTTAAGGAGGTAGTTTGTTGAGGGGAGGGCTGTAGATCATTACTTCTTTCTCTTCAGGAAGTGGCCA
CTTTGAACCATTCAAATACCACATTAGGCAAGACTGTGATAGGCCTTTTGTCTTCAAATACAACAGGCCTCCACTGACCCATCCCTCAAA
GCAGAAGGACCCTTTGAGGAGAGTACAGATGGGATTCCACAGTGGGGTGGGTGGAATGGAAACCTGTACTAGACCACCCAGAGGTTCCTT
CTAACCCACTGGTTTGGTGGGGAACTCACAGTAATTCCAAATGTACAATCAGATGTCTAGGGTCTGTTTTCGGAAGAAGCAAGAATTATC
AGTGGCACCCTCCCCACTGCCCCCAGTGTAAAACAATAGACATTCTGTGAAATGCAAAGCTATTCTTTGGTTTTTCTAGTAGTTTATCTC
ATTTTACCCTATTCTTCCTTTAAGGAAAACTCAATCTTTATCACAGTCAATTAGAGCGATCCCAAGGCATGGGACCAGGCCTGCTTGCCT
ATGTGTGATGGCAATTGGAGATCTGGATTTAGCACTGGGGTCTCAGCACCCTGCAGGTGTCTGAGACTAAGTGATCTGCCCTCCAGGTGG
CGATCACCTTCTGCTCCTAGGTACCCCCACTGGCAAGGCCAAGGTCTCCTCCACGTTTTTTCTGCAATTAATAATGTCATTTAAAAAATG
AGCAAAGCCTTATCCGAATCGGATATAGCAACTAAAGTCAATACATTTTGCAGGAGGCTAAGTGTAAGAGTGTGTGTGTGTGTGTGTGCG
TGCATGTGTGTGTGTGTGTATGTGTGTGAATAAGTCGACATAAAGTCTTTAATTTTGAGCACCTTACCAAACATAACAATAATCCATTAT
CCTTTTGGCAACACCACAAAGATCGCATCTGTTAAACAGGTACAAGTTGACATGAGGTTAGTTTAATTGTACACCATGATATTGGTGGTA
TTTATGCTGTTAAGTCCAAACCTTTATCTGTCTGTTATTCTTAATGTTGAATAAACTTTGAATTTTTTCCTTTC

>14805_14805_2_CDC27-HLF_CDC27_chr17_45258928_ENST00000527547_HLF_chr17_53345112_ENST00000226067_length(amino acids)=291AA_BP=34
MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEAFSKDKDKEKKLDDESNSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSE
NGIPPSPSQHDHSPHPPGLQPASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLAL
SSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADL
RKELGKCKNILAKYEARHGPL

--------------------------------------------------------------
>14805_14805_3_CDC27-HLF_CDC27_chr17_45258928_ENST00000531206_HLF_chr17_53345112_ENST00000226067_length(transcript)=5066nt_BP=107nt
GAGGATGACGGTGCTGCAGGAACCCGTCCAGGCTGCTATATGGCAAGCACTAAACCACTATGCTTACCGAGATGCGGTTTTCCTCGCAGA
ACGCCTTTATGCAGAAGCATTTAGTAAAGATAAAGACAAGGAAAAGAAGCTGGATGATGAGAGTAACAGCCCGACGGTCCCCCAGTCGGC
ATTCCTGGGGCCTACCTTATGGGACAAAACCCTTCCCTATGACGGAGATACTTTCCAGTTGGAATACATGGACCTGGAGGAGTTTTTGTC
AGAAAATGGCATTCCCCCCAGCCCATCTCAGCATGACCACAGCCCTCACCCTCCTGGGCTGCAGCCAGCTTCCTCGGCTGCCCCCTCGGT
CATGGACCTCAGCAGCCGGGCCTCTGCACCCCTTCACCCTGGCATCCCATCTCCGAACTGTATGCAGAGCCCCATCAGACCAGGTCAGCT
GTTGCCAGCAAACCGCAATACACCAAGTCCCATTGATCCTGACACCATCCAGGTCCCAGTGGGTTATGAGCCAGACCCAGCAGATCTTGC
CCTTTCCAGCATCCCTGGCCAGGAAATGTTTGACCCTCGCAAACGCAAGTTCTCTGAGGAAGAACTGAAGCCACAGCCCATGATCAAGAA
AGCTCGCAAAGTCTTCATCCCTGATGACCTGAAGGATGACAAGTACTGGGCAAGGCGCAGAAAGAACAACATGGCAGCCAAGCGCTCCCG
CGACGCCCGGAGGCTGAAAGAGAACCAGATCGCCATCCGGGCCTCGTTCCTGGAGAAGGAGAACTCGGCCCTCCGCCAGGAGGTGGCTGA
CTTGAGGAAGGAGCTGGGCAAATGCAAGAACATACTTGCCAAGTATGAGGCCAGGCACGGGCCCCTGTAGGATGGCATTTTTGCAGGCTG
GCTTTGGAATAGATGGACAGTTTGTTTCCTGTCTGATAGCACCACACGCAAACCAACCTTTCTGACATCAGCACTTTACCAGAGGCATAA
ACACAACTGACTCCCATTTTGGTGTGCATCTGTGTGTGTGTGCGTGTATATGTGCTTGTGCTCATGTGTGTGGTCAGCGGTATGTGCGTG
TGCGTGTTCCTTTGCTCTTGCCATTTTAAGGTAGCCCTCTCATCGTCTTTTAGTTCCAACAAAGAAAGGTGCCATGTCTTTACTAGACTG
AGGAGCCCTCTCGCGGGTCTCCCATCCCCTCCCTCCTTCACTCCTGCCTCCTCAGCTTTGCTTCATGTTCGAGCTTACCTACTCTTCCAG
GACTCTCTGCTTGGATTCACTAAAAAGGGCCCTGGTAAAATAGTGGATCTCAGTTTTTAAGAGTACAAGCTCTTGTTTCTGTTTAGTCCG
TAAGTTACCATGCTAATGAGGTGCACACAATAACTTAGCACTACTCCGCAGCTCTAGTCCTTTATAAGTTGCTTTCCTCTTACTTTCAGT
TTTGGTGATAATCGTCTTCAAATTAAAGTGCTGTTTAGATTTATTAGATCCCATATTTACTTACTGCTATCTACTAAGTTTCCTTTTAAT
TCTACCAACCCCAGATAAGTAAGAGTACTATTAATAGAACACAGAGTGTGTTTTTGCACTGTCTGTACCTAAAGCAATAATCCTATTGTA
CGCTAGAGCATGCTGCCTGAGTATTACTAGTGGACGTAGGATATTTTCCCTACCTAAGAATTTCACTGTCTTTTAAAAAACAAAAAGTAA
AGTAATGCATTTGAGCATGGCCAGACTATTCCCTAGGACAAGGAAGCAGAGGGAAATGGGAGGTCTAAGGATGAGGGGTTAATTTATCAG
TACATGAGCCAAAAACTGCGTCTTGGATTAGCCTTTGACATTGATGTGTTCGGTTTTGTTGTTCCCCTTCCCTCACACCCTGCCTCGCCC
CCACTTTTCTAGTTAACTTTTTCCATATCCCTCTTGACATTCAAAACAGTTACTTAAGATTCAGTTTTCCCACTTTTTGGTAATATATAT
ATTTTTGTGAATTATACTTTGTTGTTTTTAAAAAGAAAATCAGTTGATTAAGTTAATAAGTTGATGTTTTCTAAGGCCCTTTTTCCTAGT
GGTGTCATTTTTGAATGCCTCATAAATTAATGATTCTGAAGCTTATGTTTCTTATTCTCTGTTTGCTTTTGAACGTATGTGCTCTTATAA
AGTGGACTTCTGAAAAATGAATGTAAAAGACACTGGTGTATCTCAGAAGGGGATGGTGTTGTCACAAACTGTGGTTAATCCAATCAATTT
AAATGTTTACTATAGACCAAAAGGAGAGATTATTAAATCGTTTAATGTTTATACAGAGTAATTATAGGAAGTTCTTTTTTGTACAGTATT
TTTCAGATATAAATACTGACAATGTATTTTGGAAGACATATATTATATATAGAAAAGAGGAGAGGAAAACTATTCCATGTTTTAAAATTA
TATAGCAAAGATATATATTCACCAATGTTGTACAGAGAAGAAGTGCTTGGGGGTTTTTGAAGTCTTTAATATTTTAAGCCCTATCACTGA
CACATCAGCATGTTTTCTGCTTTAAATTAAAATTTTATGACAGTATCGAGGCTTGTGATGACGAATCCTGCTCTAAAATACACAAGGAGC
TTTCTTGTTTCTTATTAGGCCTCAGAAAGAAGTCAGTTAACGTCACCCAAAAGCACAAAATGGATTTTAGTCAAATATTTATTGGATGAT
ACAGTGTTTTTTAGGAAAAGCATCTGCCACAAAAATGTTCACTTCGAAATTCTGAGTTCCTGGAATGGCACGTTGCTGCCAGTGCCCCAG
ACAGTTCTTTTCTACCCTGCGGGCCCGCACGTTTTATGAGGTTGATATCGGTGCTATGTGTTTGGTTTATAATTTGATAGATGTTTGACT
TTAAAGATGATTGTTCTTTTGTTTCATTAAGTTGTAAAATGTCAAGAAATTCTGCTGTTACGACAAAGAAACATTTTACGCTAGATTAAA
ATATCCTTTCATCAATGGGATTTTCTAGTTTCCTGCCTTCAGAGTATCTAATCCTTTAATGATCTGGTGGTCTCCTCGTCAATCCATCAG
CAATGCTTCTCTCATAGTGTCATAGACTTGGGAAACCCAACCAGTAGGATATTTCTACAAGGTGTTCATTTTGTCACAAGCTGTAGATAA
CAGCAAGAGATGGGGGTGTATTGGAATTGCAATACATTGTTCAGGTGAATAATAAAATCAAAAACTTTTGCAATCTTAAGCAGAGATAAA
TAAAAGATAGCAATATGAGACACAGGTGGACGTAGAGTTGGCCTTTTTACAGGCAAAGAGGCGAATTGTAGAATTGTTAGATGGCAATAG
TCATTAAAAACATAGAAAAATGATGTCTTTAAGTGGAGAATTGTGGAAGGATTGTAACATGGACCATCCAAATTTATGGCCGTATCAAAT
GGTAGCTGAAAAAACTATATTTGAGCACTGGTCTCTCTTGGAATTAGATGTTTATATCAAATGAGCATCTCAAATGTTTTCTGCAGAAAA
AAATAAAAAGATTCTAATAAAATGTATTCTCTTGTGTGCCAGGAGAGGTTTCAGAAACCTACCTCGTCTTACAAATTTAAACACTTTGGA
GTCTGTACAGGTGCCTTATATGTAGGTCATTGTCACGATACACACACACGAACACTCCCTCTGGACTGGCTGCCTCTCCATCCAGGGCAG
TTAACTAGCAAACAAGGCAGATCTGCTTCATGGAGCGGGAGGCCATGGCTTGACTCTGAGTGATTTGGGTCAACCGGAGTCAGACGCATG
TCTGCACGCTGCAGCTATTATGAGAGTCCCTTTGTCATTTTTCACCTTTTCATCCTAAGCATCTTTCAGAGATTAATTATTTGGCCATTA
ACAATGAATCCAAATCATATCATACTGACATCATCTAGACATGATTTGGAAGGAACAGCTTAGGACCTCCTGATGAGGTCACATTGTTGT
TTCTTTTAACTAGACTTGGCAAAGAAAGGCAAAAATTGACCAGCCTATCTTTCTGCTGGTGCTGCCTTAAGGAGGTAGTTTGTTGAGGGG
AGGGCTGTAGATCATTACTTCTTTCTCTTCAGGAAGTGGCCACTTTGAACCATTCAAATACCACATTAGGCAAGACTGTGATAGGCCTTT
TGTCTTCAAATACAACAGGCCTCCACTGACCCATCCCTCAAAGCAGAAGGACCCTTTGAGGAGAGTACAGATGGGATTCCACAGTGGGGT
GGGTGGAATGGAAACCTGTACTAGACCACCCAGAGGTTCCTTCTAACCCACTGGTTTGGTGGGGAACTCACAGTAATTCCAAATGTACAA
TCAGATGTCTAGGGTCTGTTTTCGGAAGAAGCAAGAATTATCAGTGGCACCCTCCCCACTGCCCCCAGTGTAAAACAATAGACATTCTGT
GAAATGCAAAGCTATTCTTTGGTTTTTCTAGTAGTTTATCTCATTTTACCCTATTCTTCCTTTAAGGAAAACTCAATCTTTATCACAGTC
AATTAGAGCGATCCCAAGGCATGGGACCAGGCCTGCTTGCCTATGTGTGATGGCAATTGGAGATCTGGATTTAGCACTGGGGTCTCAGCA
CCCTGCAGGTGTCTGAGACTAAGTGATCTGCCCTCCAGGTGGCGATCACCTTCTGCTCCTAGGTACCCCCACTGGCAAGGCCAAGGTCTC
CTCCACGTTTTTTCTGCAATTAATAATGTCATTTAAAAAATGAGCAAAGCCTTATCCGAATCGGATATAGCAACTAAAGTCAATACATTT
TGCAGGAGGCTAAGTGTAAGAGTGTGTGTGTGTGTGTGTGCGTGCATGTGTGTGTGTGTGTATGTGTGTGAATAAGTCGACATAAAGTCT
TTAATTTTGAGCACCTTACCAAACATAACAATAATCCATTATCCTTTTGGCAACACCACAAAGATCGCATCTGTTAAACAGGTACAAGTT
GACATGAGGTTAGTTTAATTGTACACCATGATATTGGTGGTATTTATGCTGTTAAGTCCAAACCTTTATCTGTCTGTTATTCTTAATGTT
GAATAAACTTTGAATTTTTTCCTTTC

>14805_14805_3_CDC27-HLF_CDC27_chr17_45258928_ENST00000531206_HLF_chr17_53345112_ENST00000226067_length(amino acids)=291AA_BP=34
MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEAFSKDKDKEKKLDDESNSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSE
NGIPPSPSQHDHSPHPPGLQPASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLAL
SSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADL
RKELGKCKNILAKYEARHGPL

--------------------------------------------------------------

Top

Fusion Gene PPI Analysis for CDC27-HLF

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)

Hgene

Hgene's interactors

Tgene

Tgene's interactors

- Retained PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost PPIs in in-frame fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

- Retained PPIs, but lost function due to frame-shift fusion.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs for CDC27-HLF

Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)

Partner

Gene

UniProtAcc

DrugBank ID

Drug name

Drug activity

Drug type

Drug status

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Related Diseases for CDC27-HLF

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	CDC27	C0033578	Prostatic Neoplasms	1	CTD_human
Hgene	CDC27	C0376358	Malignant neoplasm of prostate	1	CTD_human
Tgene		C0006413	Burkitt Lymphoma	1	ORPHANET
Tgene		C0023452	Childhood Acute Lymphoblastic Leukemia	1	CTD_human
Tgene		C0023453	L2 Acute Lymphoblastic Leukemia	1	CTD_human
Tgene		C0041696	Unipolar Depression	1	PSYGENET
Tgene		C1269683	Major Depressive Disorder	1	PSYGENET
Tgene		C1292769	Precursor B-cell lymphoblastic leukemia	1	ORPHANET
Tgene		C1961102	Precursor Cell Lymphoblastic Leukemia Lymphoma	1	CTD_human

Fusion Gene Studies in Kim Lab

Fusion gene:CDC27-HLF (FusionGDB2 ID:HG996TG3131)

Fusion Gene Summary for CDC27-HLF

Fusion Gene ORF analysis for CDC27-HLF

Fusion Genomic Features for CDC27-HLF

Fusion Protein Features for CDC27-HLF

Fusion Gene Sequence for CDC27-HLF

Fusion Gene PPI Analysis for CDC27-HLF

Related Drugs for CDC27-HLF

Related Diseases for CDC27-HLF

Fusion Gene Studies
in Kim Lab