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in Kim Lab

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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDC27-HLF (FusionGDB2 ID:HG996TG3131)

Fusion Gene Summary for CDC27-HLF

check button Fusion gene summary
Fusion gene informationFusion gene name: CDC27-HLF
Fusion gene ID: hg996tg3131
HgeneTgene
Gene symbol

CDC27

HLF

Gene ID

996

3131

Gene namecell division cycle 27HLF transcription factor, PAR bZIP family member
SynonymsANAPC3|APC3|CDC27Hs|D0S1430E|D17S978E|H-NUC|HNUC|NUC2-
Cytomap('CDC27')('HLF')

17q21.32

17q22

Type of geneprotein-codingprotein-coding
Descriptioncell division cycle protein 27 homologD0S1430E, D17S978Eanaphase promoting complex subunit 3anaphase-promoting complex, protein 3cell division cycle 27 homolognuc2 homologhepatic leukemia factorHLF, PAR bZIP transcription factorPAR bZIP transcription factor
Modification date2020031320200313
UniProtAcc.

Q16534

Ensembl transtripts involved in fusion geneENST00000066544, ENST00000446365, 
ENST00000527547, ENST00000531206, 
ENST00000528748, 
Fusion gene scores* DoF score12 X 8 X 10=9601 X 1 X 1=1
# samples 161
** MAII scorelog2(16/960*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(1/1*10)=3.32192809488736
Context

PubMed: CDC27 [Title/Abstract] AND HLF [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDC27(45258928)-HLF(53345112), # samples:1
Anticipated loss of major functional domain due to fusion event.CDC27-HLF seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC27-HLF seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC27-HLF seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
CDC27-HLF seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
CDC27-HLF seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDC27

GO:0070979

protein K11-linked ubiquitination

18485873

TgeneHLF

GO:0045944

positive regulation of transcription by RNA polymerase II

8065331


check buttonFusion gene breakpoints across CDC27 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across HLF (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-52-7810-01ACDC27chr17

45258928

-HLFchr17

53345112

+


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Fusion Gene ORF analysis for CDC27-HLF

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
5CDS-5UTRENST00000066544ENST00000430986CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000066544ENST00000573945CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000066544ENST00000575345CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000446365ENST00000430986CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000446365ENST00000573945CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000446365ENST00000575345CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000527547ENST00000430986CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000527547ENST00000573945CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000527547ENST00000575345CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000531206ENST00000430986CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000531206ENST00000573945CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-5UTRENST00000531206ENST00000575345CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-intronENST00000066544ENST00000575307CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-intronENST00000446365ENST00000575307CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-intronENST00000527547ENST00000575307CDC27chr17

45258928

-HLFchr17

53345112

+
5CDS-intronENST00000531206ENST00000575307CDC27chr17

45258928

-HLFchr17

53345112

+
5UTR-3CDSENST00000528748ENST00000226067CDC27chr17

45258928

-HLFchr17

53345112

+
5UTR-5UTRENST00000528748ENST00000430986CDC27chr17

45258928

-HLFchr17

53345112

+
5UTR-5UTRENST00000528748ENST00000573945CDC27chr17

45258928

-HLFchr17

53345112

+
5UTR-5UTRENST00000528748ENST00000575345CDC27chr17

45258928

-HLFchr17

53345112

+
5UTR-intronENST00000528748ENST00000575307CDC27chr17

45258928

-HLFchr17

53345112

+
Frame-shiftENST00000446365ENST00000226067CDC27chr17

45258928

-HLFchr17

53345112

+
In-frameENST00000066544ENST00000226067CDC27chr17

45258928

-HLFchr17

53345112

+
In-frameENST00000527547ENST00000226067CDC27chr17

45258928

-HLFchr17

53345112

+
In-frameENST00000531206ENST00000226067CDC27chr17

45258928

-HLFchr17

53345112

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000066544CDC27chr1745258928-ENST00000226067HLFchr1753345112+515619794969291
ENST00000531206CDC27chr1745258928-ENST00000226067HLFchr1753345112+50661074879291
ENST00000527547CDC27chr1745258928-ENST00000226067HLFchr1753345112+511415552927291

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000066544ENST00000226067CDC27chr1745258928-HLFchr1753345112+0.00032860.99967146
ENST00000531206ENST00000226067CDC27chr1745258928-HLFchr1753345112+0.0003024910.99969757
ENST00000527547ENST00000226067CDC27chr1745258928-HLFchr1753345112+0.0003159240.9996841

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Fusion Genomic Features for CDC27-HLF


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CDC27chr1745258927-HLFchr1753345111+0.0003766660.9996233
CDC27chr1745258927-HLFchr1753345111+0.0003766660.9996233

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CDC27-HLF


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:45258928/chr17:53345112)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.HLF

Q16534

FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-2196_3534825.0RepeatNote=TPR 1
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-2196_3534831.0RepeatNote=TPR 1
TgeneHLFchr17:45258928chr17:53345112ENST0000022606704158_20938296.0Compositional biasNote=Pro-rich (proline/acidic region (PAR))
TgeneHLFchr17:45258928chr17:53345112ENST0000022606704225_28838296.0DomainbZIP
TgeneHLFchr17:45258928chr17:53345112ENST0000022606704227_24738296.0RegionBasic motif
TgeneHLFchr17:45258928chr17:53345112ENST0000022606704248_25538296.0RegionLeucine-zipper

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-219115_14534825.0RepeatNote=TPR 4
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-21938_6534825.0RepeatNote=TPR 2
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-219465_49534825.0RepeatNote=TPR 5
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-219499_52834825.0RepeatNote=TPR 6
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-219533_56334825.0RepeatNote=TPR 7
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-219567_59834825.0RepeatNote=TPR 8
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-219601_63134825.0RepeatNote=TPR 9
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-219635_66734825.0RepeatNote=TPR 10
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-219670_70234825.0RepeatNote=TPR 11
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-21967_9934825.0RepeatNote=TPR 3
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-219704_73434825.0RepeatNote=TPR 12
HgeneCDC27chr17:45258928chr17:53345112ENST00000066544-219737_76834825.0RepeatNote=TPR 13
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-219115_14534831.0RepeatNote=TPR 4
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-21938_6534831.0RepeatNote=TPR 2
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-219465_49534831.0RepeatNote=TPR 5
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-219499_52834831.0RepeatNote=TPR 6
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-219533_56334831.0RepeatNote=TPR 7
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-219567_59834831.0RepeatNote=TPR 8
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-219601_63134831.0RepeatNote=TPR 9
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-219635_66734831.0RepeatNote=TPR 10
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-219670_70234831.0RepeatNote=TPR 11
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-21967_9934831.0RepeatNote=TPR 3
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-219704_73434831.0RepeatNote=TPR 12
HgeneCDC27chr17:45258928chr17:53345112ENST00000531206-219737_76834831.0RepeatNote=TPR 13


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Fusion Gene Sequence for CDC27-HLF


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>14805_14805_1_CDC27-HLF_CDC27_chr17_45258928_ENST00000066544_HLF_chr17_53345112_ENST00000226067_length(transcript)=5156nt_BP=197nt
TCGCTGGTGAGTTTAAATGAGCAGGGGCTGGCCGGGCCGGAGCCGCTACAGGGGGGGCCTGAGGCACTGCAGAAAGTGGGCCTGAGCCTC
GAGGATGACGGTGCTGCAGGAACCCGTCCAGGCTGCTATATGGCAAGCACTAAACCACTATGCTTACCGAGATGCGGTTTTCCTCGCAGA
ACGCCTTTATGCAGAAGCATTTAGTAAAGATAAAGACAAGGAAAAGAAGCTGGATGATGAGAGTAACAGCCCGACGGTCCCCCAGTCGGC
ATTCCTGGGGCCTACCTTATGGGACAAAACCCTTCCCTATGACGGAGATACTTTCCAGTTGGAATACATGGACCTGGAGGAGTTTTTGTC
AGAAAATGGCATTCCCCCCAGCCCATCTCAGCATGACCACAGCCCTCACCCTCCTGGGCTGCAGCCAGCTTCCTCGGCTGCCCCCTCGGT
CATGGACCTCAGCAGCCGGGCCTCTGCACCCCTTCACCCTGGCATCCCATCTCCGAACTGTATGCAGAGCCCCATCAGACCAGGTCAGCT
GTTGCCAGCAAACCGCAATACACCAAGTCCCATTGATCCTGACACCATCCAGGTCCCAGTGGGTTATGAGCCAGACCCAGCAGATCTTGC
CCTTTCCAGCATCCCTGGCCAGGAAATGTTTGACCCTCGCAAACGCAAGTTCTCTGAGGAAGAACTGAAGCCACAGCCCATGATCAAGAA
AGCTCGCAAAGTCTTCATCCCTGATGACCTGAAGGATGACAAGTACTGGGCAAGGCGCAGAAAGAACAACATGGCAGCCAAGCGCTCCCG
CGACGCCCGGAGGCTGAAAGAGAACCAGATCGCCATCCGGGCCTCGTTCCTGGAGAAGGAGAACTCGGCCCTCCGCCAGGAGGTGGCTGA
CTTGAGGAAGGAGCTGGGCAAATGCAAGAACATACTTGCCAAGTATGAGGCCAGGCACGGGCCCCTGTAGGATGGCATTTTTGCAGGCTG
GCTTTGGAATAGATGGACAGTTTGTTTCCTGTCTGATAGCACCACACGCAAACCAACCTTTCTGACATCAGCACTTTACCAGAGGCATAA
ACACAACTGACTCCCATTTTGGTGTGCATCTGTGTGTGTGTGCGTGTATATGTGCTTGTGCTCATGTGTGTGGTCAGCGGTATGTGCGTG
TGCGTGTTCCTTTGCTCTTGCCATTTTAAGGTAGCCCTCTCATCGTCTTTTAGTTCCAACAAAGAAAGGTGCCATGTCTTTACTAGACTG
AGGAGCCCTCTCGCGGGTCTCCCATCCCCTCCCTCCTTCACTCCTGCCTCCTCAGCTTTGCTTCATGTTCGAGCTTACCTACTCTTCCAG
GACTCTCTGCTTGGATTCACTAAAAAGGGCCCTGGTAAAATAGTGGATCTCAGTTTTTAAGAGTACAAGCTCTTGTTTCTGTTTAGTCCG
TAAGTTACCATGCTAATGAGGTGCACACAATAACTTAGCACTACTCCGCAGCTCTAGTCCTTTATAAGTTGCTTTCCTCTTACTTTCAGT
TTTGGTGATAATCGTCTTCAAATTAAAGTGCTGTTTAGATTTATTAGATCCCATATTTACTTACTGCTATCTACTAAGTTTCCTTTTAAT
TCTACCAACCCCAGATAAGTAAGAGTACTATTAATAGAACACAGAGTGTGTTTTTGCACTGTCTGTACCTAAAGCAATAATCCTATTGTA
CGCTAGAGCATGCTGCCTGAGTATTACTAGTGGACGTAGGATATTTTCCCTACCTAAGAATTTCACTGTCTTTTAAAAAACAAAAAGTAA
AGTAATGCATTTGAGCATGGCCAGACTATTCCCTAGGACAAGGAAGCAGAGGGAAATGGGAGGTCTAAGGATGAGGGGTTAATTTATCAG
TACATGAGCCAAAAACTGCGTCTTGGATTAGCCTTTGACATTGATGTGTTCGGTTTTGTTGTTCCCCTTCCCTCACACCCTGCCTCGCCC
CCACTTTTCTAGTTAACTTTTTCCATATCCCTCTTGACATTCAAAACAGTTACTTAAGATTCAGTTTTCCCACTTTTTGGTAATATATAT
ATTTTTGTGAATTATACTTTGTTGTTTTTAAAAAGAAAATCAGTTGATTAAGTTAATAAGTTGATGTTTTCTAAGGCCCTTTTTCCTAGT
GGTGTCATTTTTGAATGCCTCATAAATTAATGATTCTGAAGCTTATGTTTCTTATTCTCTGTTTGCTTTTGAACGTATGTGCTCTTATAA
AGTGGACTTCTGAAAAATGAATGTAAAAGACACTGGTGTATCTCAGAAGGGGATGGTGTTGTCACAAACTGTGGTTAATCCAATCAATTT
AAATGTTTACTATAGACCAAAAGGAGAGATTATTAAATCGTTTAATGTTTATACAGAGTAATTATAGGAAGTTCTTTTTTGTACAGTATT
TTTCAGATATAAATACTGACAATGTATTTTGGAAGACATATATTATATATAGAAAAGAGGAGAGGAAAACTATTCCATGTTTTAAAATTA
TATAGCAAAGATATATATTCACCAATGTTGTACAGAGAAGAAGTGCTTGGGGGTTTTTGAAGTCTTTAATATTTTAAGCCCTATCACTGA
CACATCAGCATGTTTTCTGCTTTAAATTAAAATTTTATGACAGTATCGAGGCTTGTGATGACGAATCCTGCTCTAAAATACACAAGGAGC
TTTCTTGTTTCTTATTAGGCCTCAGAAAGAAGTCAGTTAACGTCACCCAAAAGCACAAAATGGATTTTAGTCAAATATTTATTGGATGAT
ACAGTGTTTTTTAGGAAAAGCATCTGCCACAAAAATGTTCACTTCGAAATTCTGAGTTCCTGGAATGGCACGTTGCTGCCAGTGCCCCAG
ACAGTTCTTTTCTACCCTGCGGGCCCGCACGTTTTATGAGGTTGATATCGGTGCTATGTGTTTGGTTTATAATTTGATAGATGTTTGACT
TTAAAGATGATTGTTCTTTTGTTTCATTAAGTTGTAAAATGTCAAGAAATTCTGCTGTTACGACAAAGAAACATTTTACGCTAGATTAAA
ATATCCTTTCATCAATGGGATTTTCTAGTTTCCTGCCTTCAGAGTATCTAATCCTTTAATGATCTGGTGGTCTCCTCGTCAATCCATCAG
CAATGCTTCTCTCATAGTGTCATAGACTTGGGAAACCCAACCAGTAGGATATTTCTACAAGGTGTTCATTTTGTCACAAGCTGTAGATAA
CAGCAAGAGATGGGGGTGTATTGGAATTGCAATACATTGTTCAGGTGAATAATAAAATCAAAAACTTTTGCAATCTTAAGCAGAGATAAA
TAAAAGATAGCAATATGAGACACAGGTGGACGTAGAGTTGGCCTTTTTACAGGCAAAGAGGCGAATTGTAGAATTGTTAGATGGCAATAG
TCATTAAAAACATAGAAAAATGATGTCTTTAAGTGGAGAATTGTGGAAGGATTGTAACATGGACCATCCAAATTTATGGCCGTATCAAAT
GGTAGCTGAAAAAACTATATTTGAGCACTGGTCTCTCTTGGAATTAGATGTTTATATCAAATGAGCATCTCAAATGTTTTCTGCAGAAAA
AAATAAAAAGATTCTAATAAAATGTATTCTCTTGTGTGCCAGGAGAGGTTTCAGAAACCTACCTCGTCTTACAAATTTAAACACTTTGGA
GTCTGTACAGGTGCCTTATATGTAGGTCATTGTCACGATACACACACACGAACACTCCCTCTGGACTGGCTGCCTCTCCATCCAGGGCAG
TTAACTAGCAAACAAGGCAGATCTGCTTCATGGAGCGGGAGGCCATGGCTTGACTCTGAGTGATTTGGGTCAACCGGAGTCAGACGCATG
TCTGCACGCTGCAGCTATTATGAGAGTCCCTTTGTCATTTTTCACCTTTTCATCCTAAGCATCTTTCAGAGATTAATTATTTGGCCATTA
ACAATGAATCCAAATCATATCATACTGACATCATCTAGACATGATTTGGAAGGAACAGCTTAGGACCTCCTGATGAGGTCACATTGTTGT
TTCTTTTAACTAGACTTGGCAAAGAAAGGCAAAAATTGACCAGCCTATCTTTCTGCTGGTGCTGCCTTAAGGAGGTAGTTTGTTGAGGGG
AGGGCTGTAGATCATTACTTCTTTCTCTTCAGGAAGTGGCCACTTTGAACCATTCAAATACCACATTAGGCAAGACTGTGATAGGCCTTT
TGTCTTCAAATACAACAGGCCTCCACTGACCCATCCCTCAAAGCAGAAGGACCCTTTGAGGAGAGTACAGATGGGATTCCACAGTGGGGT
GGGTGGAATGGAAACCTGTACTAGACCACCCAGAGGTTCCTTCTAACCCACTGGTTTGGTGGGGAACTCACAGTAATTCCAAATGTACAA
TCAGATGTCTAGGGTCTGTTTTCGGAAGAAGCAAGAATTATCAGTGGCACCCTCCCCACTGCCCCCAGTGTAAAACAATAGACATTCTGT
GAAATGCAAAGCTATTCTTTGGTTTTTCTAGTAGTTTATCTCATTTTACCCTATTCTTCCTTTAAGGAAAACTCAATCTTTATCACAGTC
AATTAGAGCGATCCCAAGGCATGGGACCAGGCCTGCTTGCCTATGTGTGATGGCAATTGGAGATCTGGATTTAGCACTGGGGTCTCAGCA
CCCTGCAGGTGTCTGAGACTAAGTGATCTGCCCTCCAGGTGGCGATCACCTTCTGCTCCTAGGTACCCCCACTGGCAAGGCCAAGGTCTC
CTCCACGTTTTTTCTGCAATTAATAATGTCATTTAAAAAATGAGCAAAGCCTTATCCGAATCGGATATAGCAACTAAAGTCAATACATTT
TGCAGGAGGCTAAGTGTAAGAGTGTGTGTGTGTGTGTGTGCGTGCATGTGTGTGTGTGTGTATGTGTGTGAATAAGTCGACATAAAGTCT
TTAATTTTGAGCACCTTACCAAACATAACAATAATCCATTATCCTTTTGGCAACACCACAAAGATCGCATCTGTTAAACAGGTACAAGTT
GACATGAGGTTAGTTTAATTGTACACCATGATATTGGTGGTATTTATGCTGTTAAGTCCAAACCTTTATCTGTCTGTTATTCTTAATGTT

>14805_14805_1_CDC27-HLF_CDC27_chr17_45258928_ENST00000066544_HLF_chr17_53345112_ENST00000226067_length(amino acids)=291AA_BP=34
MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEAFSKDKDKEKKLDDESNSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSE
NGIPPSPSQHDHSPHPPGLQPASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLAL
SSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADL

--------------------------------------------------------------
>14805_14805_2_CDC27-HLF_CDC27_chr17_45258928_ENST00000527547_HLF_chr17_53345112_ENST00000226067_length(transcript)=5114nt_BP=155nt
CCGCTACAGGGGGGGCCTGAGGCACTGCAGAAAGTGGGCCTGAGCCTCGAGGATGACGGTGCTGCAGGAACCCGTCCAGGCTGCTATATG
GCAAGCACTAAACCACTATGCTTACCGAGATGCGGTTTTCCTCGCAGAACGCCTTTATGCAGAAGCATTTAGTAAAGATAAAGACAAGGA
AAAGAAGCTGGATGATGAGAGTAACAGCCCGACGGTCCCCCAGTCGGCATTCCTGGGGCCTACCTTATGGGACAAAACCCTTCCCTATGA
CGGAGATACTTTCCAGTTGGAATACATGGACCTGGAGGAGTTTTTGTCAGAAAATGGCATTCCCCCCAGCCCATCTCAGCATGACCACAG
CCCTCACCCTCCTGGGCTGCAGCCAGCTTCCTCGGCTGCCCCCTCGGTCATGGACCTCAGCAGCCGGGCCTCTGCACCCCTTCACCCTGG
CATCCCATCTCCGAACTGTATGCAGAGCCCCATCAGACCAGGTCAGCTGTTGCCAGCAAACCGCAATACACCAAGTCCCATTGATCCTGA
CACCATCCAGGTCCCAGTGGGTTATGAGCCAGACCCAGCAGATCTTGCCCTTTCCAGCATCCCTGGCCAGGAAATGTTTGACCCTCGCAA
ACGCAAGTTCTCTGAGGAAGAACTGAAGCCACAGCCCATGATCAAGAAAGCTCGCAAAGTCTTCATCCCTGATGACCTGAAGGATGACAA
GTACTGGGCAAGGCGCAGAAAGAACAACATGGCAGCCAAGCGCTCCCGCGACGCCCGGAGGCTGAAAGAGAACCAGATCGCCATCCGGGC
CTCGTTCCTGGAGAAGGAGAACTCGGCCCTCCGCCAGGAGGTGGCTGACTTGAGGAAGGAGCTGGGCAAATGCAAGAACATACTTGCCAA
GTATGAGGCCAGGCACGGGCCCCTGTAGGATGGCATTTTTGCAGGCTGGCTTTGGAATAGATGGACAGTTTGTTTCCTGTCTGATAGCAC
CACACGCAAACCAACCTTTCTGACATCAGCACTTTACCAGAGGCATAAACACAACTGACTCCCATTTTGGTGTGCATCTGTGTGTGTGTG
CGTGTATATGTGCTTGTGCTCATGTGTGTGGTCAGCGGTATGTGCGTGTGCGTGTTCCTTTGCTCTTGCCATTTTAAGGTAGCCCTCTCA
TCGTCTTTTAGTTCCAACAAAGAAAGGTGCCATGTCTTTACTAGACTGAGGAGCCCTCTCGCGGGTCTCCCATCCCCTCCCTCCTTCACT
CCTGCCTCCTCAGCTTTGCTTCATGTTCGAGCTTACCTACTCTTCCAGGACTCTCTGCTTGGATTCACTAAAAAGGGCCCTGGTAAAATA
GTGGATCTCAGTTTTTAAGAGTACAAGCTCTTGTTTCTGTTTAGTCCGTAAGTTACCATGCTAATGAGGTGCACACAATAACTTAGCACT
ACTCCGCAGCTCTAGTCCTTTATAAGTTGCTTTCCTCTTACTTTCAGTTTTGGTGATAATCGTCTTCAAATTAAAGTGCTGTTTAGATTT
ATTAGATCCCATATTTACTTACTGCTATCTACTAAGTTTCCTTTTAATTCTACCAACCCCAGATAAGTAAGAGTACTATTAATAGAACAC
AGAGTGTGTTTTTGCACTGTCTGTACCTAAAGCAATAATCCTATTGTACGCTAGAGCATGCTGCCTGAGTATTACTAGTGGACGTAGGAT
ATTTTCCCTACCTAAGAATTTCACTGTCTTTTAAAAAACAAAAAGTAAAGTAATGCATTTGAGCATGGCCAGACTATTCCCTAGGACAAG
GAAGCAGAGGGAAATGGGAGGTCTAAGGATGAGGGGTTAATTTATCAGTACATGAGCCAAAAACTGCGTCTTGGATTAGCCTTTGACATT
GATGTGTTCGGTTTTGTTGTTCCCCTTCCCTCACACCCTGCCTCGCCCCCACTTTTCTAGTTAACTTTTTCCATATCCCTCTTGACATTC
AAAACAGTTACTTAAGATTCAGTTTTCCCACTTTTTGGTAATATATATATTTTTGTGAATTATACTTTGTTGTTTTTAAAAAGAAAATCA
GTTGATTAAGTTAATAAGTTGATGTTTTCTAAGGCCCTTTTTCCTAGTGGTGTCATTTTTGAATGCCTCATAAATTAATGATTCTGAAGC
TTATGTTTCTTATTCTCTGTTTGCTTTTGAACGTATGTGCTCTTATAAAGTGGACTTCTGAAAAATGAATGTAAAAGACACTGGTGTATC
TCAGAAGGGGATGGTGTTGTCACAAACTGTGGTTAATCCAATCAATTTAAATGTTTACTATAGACCAAAAGGAGAGATTATTAAATCGTT
TAATGTTTATACAGAGTAATTATAGGAAGTTCTTTTTTGTACAGTATTTTTCAGATATAAATACTGACAATGTATTTTGGAAGACATATA
TTATATATAGAAAAGAGGAGAGGAAAACTATTCCATGTTTTAAAATTATATAGCAAAGATATATATTCACCAATGTTGTACAGAGAAGAA
GTGCTTGGGGGTTTTTGAAGTCTTTAATATTTTAAGCCCTATCACTGACACATCAGCATGTTTTCTGCTTTAAATTAAAATTTTATGACA
GTATCGAGGCTTGTGATGACGAATCCTGCTCTAAAATACACAAGGAGCTTTCTTGTTTCTTATTAGGCCTCAGAAAGAAGTCAGTTAACG
TCACCCAAAAGCACAAAATGGATTTTAGTCAAATATTTATTGGATGATACAGTGTTTTTTAGGAAAAGCATCTGCCACAAAAATGTTCAC
TTCGAAATTCTGAGTTCCTGGAATGGCACGTTGCTGCCAGTGCCCCAGACAGTTCTTTTCTACCCTGCGGGCCCGCACGTTTTATGAGGT
TGATATCGGTGCTATGTGTTTGGTTTATAATTTGATAGATGTTTGACTTTAAAGATGATTGTTCTTTTGTTTCATTAAGTTGTAAAATGT
CAAGAAATTCTGCTGTTACGACAAAGAAACATTTTACGCTAGATTAAAATATCCTTTCATCAATGGGATTTTCTAGTTTCCTGCCTTCAG
AGTATCTAATCCTTTAATGATCTGGTGGTCTCCTCGTCAATCCATCAGCAATGCTTCTCTCATAGTGTCATAGACTTGGGAAACCCAACC
AGTAGGATATTTCTACAAGGTGTTCATTTTGTCACAAGCTGTAGATAACAGCAAGAGATGGGGGTGTATTGGAATTGCAATACATTGTTC
AGGTGAATAATAAAATCAAAAACTTTTGCAATCTTAAGCAGAGATAAATAAAAGATAGCAATATGAGACACAGGTGGACGTAGAGTTGGC
CTTTTTACAGGCAAAGAGGCGAATTGTAGAATTGTTAGATGGCAATAGTCATTAAAAACATAGAAAAATGATGTCTTTAAGTGGAGAATT
GTGGAAGGATTGTAACATGGACCATCCAAATTTATGGCCGTATCAAATGGTAGCTGAAAAAACTATATTTGAGCACTGGTCTCTCTTGGA
ATTAGATGTTTATATCAAATGAGCATCTCAAATGTTTTCTGCAGAAAAAAATAAAAAGATTCTAATAAAATGTATTCTCTTGTGTGCCAG
GAGAGGTTTCAGAAACCTACCTCGTCTTACAAATTTAAACACTTTGGAGTCTGTACAGGTGCCTTATATGTAGGTCATTGTCACGATACA
CACACACGAACACTCCCTCTGGACTGGCTGCCTCTCCATCCAGGGCAGTTAACTAGCAAACAAGGCAGATCTGCTTCATGGAGCGGGAGG
CCATGGCTTGACTCTGAGTGATTTGGGTCAACCGGAGTCAGACGCATGTCTGCACGCTGCAGCTATTATGAGAGTCCCTTTGTCATTTTT
CACCTTTTCATCCTAAGCATCTTTCAGAGATTAATTATTTGGCCATTAACAATGAATCCAAATCATATCATACTGACATCATCTAGACAT
GATTTGGAAGGAACAGCTTAGGACCTCCTGATGAGGTCACATTGTTGTTTCTTTTAACTAGACTTGGCAAAGAAAGGCAAAAATTGACCA
GCCTATCTTTCTGCTGGTGCTGCCTTAAGGAGGTAGTTTGTTGAGGGGAGGGCTGTAGATCATTACTTCTTTCTCTTCAGGAAGTGGCCA
CTTTGAACCATTCAAATACCACATTAGGCAAGACTGTGATAGGCCTTTTGTCTTCAAATACAACAGGCCTCCACTGACCCATCCCTCAAA
GCAGAAGGACCCTTTGAGGAGAGTACAGATGGGATTCCACAGTGGGGTGGGTGGAATGGAAACCTGTACTAGACCACCCAGAGGTTCCTT
CTAACCCACTGGTTTGGTGGGGAACTCACAGTAATTCCAAATGTACAATCAGATGTCTAGGGTCTGTTTTCGGAAGAAGCAAGAATTATC
AGTGGCACCCTCCCCACTGCCCCCAGTGTAAAACAATAGACATTCTGTGAAATGCAAAGCTATTCTTTGGTTTTTCTAGTAGTTTATCTC
ATTTTACCCTATTCTTCCTTTAAGGAAAACTCAATCTTTATCACAGTCAATTAGAGCGATCCCAAGGCATGGGACCAGGCCTGCTTGCCT
ATGTGTGATGGCAATTGGAGATCTGGATTTAGCACTGGGGTCTCAGCACCCTGCAGGTGTCTGAGACTAAGTGATCTGCCCTCCAGGTGG
CGATCACCTTCTGCTCCTAGGTACCCCCACTGGCAAGGCCAAGGTCTCCTCCACGTTTTTTCTGCAATTAATAATGTCATTTAAAAAATG
AGCAAAGCCTTATCCGAATCGGATATAGCAACTAAAGTCAATACATTTTGCAGGAGGCTAAGTGTAAGAGTGTGTGTGTGTGTGTGTGCG
TGCATGTGTGTGTGTGTGTATGTGTGTGAATAAGTCGACATAAAGTCTTTAATTTTGAGCACCTTACCAAACATAACAATAATCCATTAT
CCTTTTGGCAACACCACAAAGATCGCATCTGTTAAACAGGTACAAGTTGACATGAGGTTAGTTTAATTGTACACCATGATATTGGTGGTA

>14805_14805_2_CDC27-HLF_CDC27_chr17_45258928_ENST00000527547_HLF_chr17_53345112_ENST00000226067_length(amino acids)=291AA_BP=34
MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEAFSKDKDKEKKLDDESNSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSE
NGIPPSPSQHDHSPHPPGLQPASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLAL
SSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADL

--------------------------------------------------------------
>14805_14805_3_CDC27-HLF_CDC27_chr17_45258928_ENST00000531206_HLF_chr17_53345112_ENST00000226067_length(transcript)=5066nt_BP=107nt
GAGGATGACGGTGCTGCAGGAACCCGTCCAGGCTGCTATATGGCAAGCACTAAACCACTATGCTTACCGAGATGCGGTTTTCCTCGCAGA
ACGCCTTTATGCAGAAGCATTTAGTAAAGATAAAGACAAGGAAAAGAAGCTGGATGATGAGAGTAACAGCCCGACGGTCCCCCAGTCGGC
ATTCCTGGGGCCTACCTTATGGGACAAAACCCTTCCCTATGACGGAGATACTTTCCAGTTGGAATACATGGACCTGGAGGAGTTTTTGTC
AGAAAATGGCATTCCCCCCAGCCCATCTCAGCATGACCACAGCCCTCACCCTCCTGGGCTGCAGCCAGCTTCCTCGGCTGCCCCCTCGGT
CATGGACCTCAGCAGCCGGGCCTCTGCACCCCTTCACCCTGGCATCCCATCTCCGAACTGTATGCAGAGCCCCATCAGACCAGGTCAGCT
GTTGCCAGCAAACCGCAATACACCAAGTCCCATTGATCCTGACACCATCCAGGTCCCAGTGGGTTATGAGCCAGACCCAGCAGATCTTGC
CCTTTCCAGCATCCCTGGCCAGGAAATGTTTGACCCTCGCAAACGCAAGTTCTCTGAGGAAGAACTGAAGCCACAGCCCATGATCAAGAA
AGCTCGCAAAGTCTTCATCCCTGATGACCTGAAGGATGACAAGTACTGGGCAAGGCGCAGAAAGAACAACATGGCAGCCAAGCGCTCCCG
CGACGCCCGGAGGCTGAAAGAGAACCAGATCGCCATCCGGGCCTCGTTCCTGGAGAAGGAGAACTCGGCCCTCCGCCAGGAGGTGGCTGA
CTTGAGGAAGGAGCTGGGCAAATGCAAGAACATACTTGCCAAGTATGAGGCCAGGCACGGGCCCCTGTAGGATGGCATTTTTGCAGGCTG
GCTTTGGAATAGATGGACAGTTTGTTTCCTGTCTGATAGCACCACACGCAAACCAACCTTTCTGACATCAGCACTTTACCAGAGGCATAA
ACACAACTGACTCCCATTTTGGTGTGCATCTGTGTGTGTGTGCGTGTATATGTGCTTGTGCTCATGTGTGTGGTCAGCGGTATGTGCGTG
TGCGTGTTCCTTTGCTCTTGCCATTTTAAGGTAGCCCTCTCATCGTCTTTTAGTTCCAACAAAGAAAGGTGCCATGTCTTTACTAGACTG
AGGAGCCCTCTCGCGGGTCTCCCATCCCCTCCCTCCTTCACTCCTGCCTCCTCAGCTTTGCTTCATGTTCGAGCTTACCTACTCTTCCAG
GACTCTCTGCTTGGATTCACTAAAAAGGGCCCTGGTAAAATAGTGGATCTCAGTTTTTAAGAGTACAAGCTCTTGTTTCTGTTTAGTCCG
TAAGTTACCATGCTAATGAGGTGCACACAATAACTTAGCACTACTCCGCAGCTCTAGTCCTTTATAAGTTGCTTTCCTCTTACTTTCAGT
TTTGGTGATAATCGTCTTCAAATTAAAGTGCTGTTTAGATTTATTAGATCCCATATTTACTTACTGCTATCTACTAAGTTTCCTTTTAAT
TCTACCAACCCCAGATAAGTAAGAGTACTATTAATAGAACACAGAGTGTGTTTTTGCACTGTCTGTACCTAAAGCAATAATCCTATTGTA
CGCTAGAGCATGCTGCCTGAGTATTACTAGTGGACGTAGGATATTTTCCCTACCTAAGAATTTCACTGTCTTTTAAAAAACAAAAAGTAA
AGTAATGCATTTGAGCATGGCCAGACTATTCCCTAGGACAAGGAAGCAGAGGGAAATGGGAGGTCTAAGGATGAGGGGTTAATTTATCAG
TACATGAGCCAAAAACTGCGTCTTGGATTAGCCTTTGACATTGATGTGTTCGGTTTTGTTGTTCCCCTTCCCTCACACCCTGCCTCGCCC
CCACTTTTCTAGTTAACTTTTTCCATATCCCTCTTGACATTCAAAACAGTTACTTAAGATTCAGTTTTCCCACTTTTTGGTAATATATAT
ATTTTTGTGAATTATACTTTGTTGTTTTTAAAAAGAAAATCAGTTGATTAAGTTAATAAGTTGATGTTTTCTAAGGCCCTTTTTCCTAGT
GGTGTCATTTTTGAATGCCTCATAAATTAATGATTCTGAAGCTTATGTTTCTTATTCTCTGTTTGCTTTTGAACGTATGTGCTCTTATAA
AGTGGACTTCTGAAAAATGAATGTAAAAGACACTGGTGTATCTCAGAAGGGGATGGTGTTGTCACAAACTGTGGTTAATCCAATCAATTT
AAATGTTTACTATAGACCAAAAGGAGAGATTATTAAATCGTTTAATGTTTATACAGAGTAATTATAGGAAGTTCTTTTTTGTACAGTATT
TTTCAGATATAAATACTGACAATGTATTTTGGAAGACATATATTATATATAGAAAAGAGGAGAGGAAAACTATTCCATGTTTTAAAATTA
TATAGCAAAGATATATATTCACCAATGTTGTACAGAGAAGAAGTGCTTGGGGGTTTTTGAAGTCTTTAATATTTTAAGCCCTATCACTGA
CACATCAGCATGTTTTCTGCTTTAAATTAAAATTTTATGACAGTATCGAGGCTTGTGATGACGAATCCTGCTCTAAAATACACAAGGAGC
TTTCTTGTTTCTTATTAGGCCTCAGAAAGAAGTCAGTTAACGTCACCCAAAAGCACAAAATGGATTTTAGTCAAATATTTATTGGATGAT
ACAGTGTTTTTTAGGAAAAGCATCTGCCACAAAAATGTTCACTTCGAAATTCTGAGTTCCTGGAATGGCACGTTGCTGCCAGTGCCCCAG
ACAGTTCTTTTCTACCCTGCGGGCCCGCACGTTTTATGAGGTTGATATCGGTGCTATGTGTTTGGTTTATAATTTGATAGATGTTTGACT
TTAAAGATGATTGTTCTTTTGTTTCATTAAGTTGTAAAATGTCAAGAAATTCTGCTGTTACGACAAAGAAACATTTTACGCTAGATTAAA
ATATCCTTTCATCAATGGGATTTTCTAGTTTCCTGCCTTCAGAGTATCTAATCCTTTAATGATCTGGTGGTCTCCTCGTCAATCCATCAG
CAATGCTTCTCTCATAGTGTCATAGACTTGGGAAACCCAACCAGTAGGATATTTCTACAAGGTGTTCATTTTGTCACAAGCTGTAGATAA
CAGCAAGAGATGGGGGTGTATTGGAATTGCAATACATTGTTCAGGTGAATAATAAAATCAAAAACTTTTGCAATCTTAAGCAGAGATAAA
TAAAAGATAGCAATATGAGACACAGGTGGACGTAGAGTTGGCCTTTTTACAGGCAAAGAGGCGAATTGTAGAATTGTTAGATGGCAATAG
TCATTAAAAACATAGAAAAATGATGTCTTTAAGTGGAGAATTGTGGAAGGATTGTAACATGGACCATCCAAATTTATGGCCGTATCAAAT
GGTAGCTGAAAAAACTATATTTGAGCACTGGTCTCTCTTGGAATTAGATGTTTATATCAAATGAGCATCTCAAATGTTTTCTGCAGAAAA
AAATAAAAAGATTCTAATAAAATGTATTCTCTTGTGTGCCAGGAGAGGTTTCAGAAACCTACCTCGTCTTACAAATTTAAACACTTTGGA
GTCTGTACAGGTGCCTTATATGTAGGTCATTGTCACGATACACACACACGAACACTCCCTCTGGACTGGCTGCCTCTCCATCCAGGGCAG
TTAACTAGCAAACAAGGCAGATCTGCTTCATGGAGCGGGAGGCCATGGCTTGACTCTGAGTGATTTGGGTCAACCGGAGTCAGACGCATG
TCTGCACGCTGCAGCTATTATGAGAGTCCCTTTGTCATTTTTCACCTTTTCATCCTAAGCATCTTTCAGAGATTAATTATTTGGCCATTA
ACAATGAATCCAAATCATATCATACTGACATCATCTAGACATGATTTGGAAGGAACAGCTTAGGACCTCCTGATGAGGTCACATTGTTGT
TTCTTTTAACTAGACTTGGCAAAGAAAGGCAAAAATTGACCAGCCTATCTTTCTGCTGGTGCTGCCTTAAGGAGGTAGTTTGTTGAGGGG
AGGGCTGTAGATCATTACTTCTTTCTCTTCAGGAAGTGGCCACTTTGAACCATTCAAATACCACATTAGGCAAGACTGTGATAGGCCTTT
TGTCTTCAAATACAACAGGCCTCCACTGACCCATCCCTCAAAGCAGAAGGACCCTTTGAGGAGAGTACAGATGGGATTCCACAGTGGGGT
GGGTGGAATGGAAACCTGTACTAGACCACCCAGAGGTTCCTTCTAACCCACTGGTTTGGTGGGGAACTCACAGTAATTCCAAATGTACAA
TCAGATGTCTAGGGTCTGTTTTCGGAAGAAGCAAGAATTATCAGTGGCACCCTCCCCACTGCCCCCAGTGTAAAACAATAGACATTCTGT
GAAATGCAAAGCTATTCTTTGGTTTTTCTAGTAGTTTATCTCATTTTACCCTATTCTTCCTTTAAGGAAAACTCAATCTTTATCACAGTC
AATTAGAGCGATCCCAAGGCATGGGACCAGGCCTGCTTGCCTATGTGTGATGGCAATTGGAGATCTGGATTTAGCACTGGGGTCTCAGCA
CCCTGCAGGTGTCTGAGACTAAGTGATCTGCCCTCCAGGTGGCGATCACCTTCTGCTCCTAGGTACCCCCACTGGCAAGGCCAAGGTCTC
CTCCACGTTTTTTCTGCAATTAATAATGTCATTTAAAAAATGAGCAAAGCCTTATCCGAATCGGATATAGCAACTAAAGTCAATACATTT
TGCAGGAGGCTAAGTGTAAGAGTGTGTGTGTGTGTGTGTGCGTGCATGTGTGTGTGTGTGTATGTGTGTGAATAAGTCGACATAAAGTCT
TTAATTTTGAGCACCTTACCAAACATAACAATAATCCATTATCCTTTTGGCAACACCACAAAGATCGCATCTGTTAAACAGGTACAAGTT
GACATGAGGTTAGTTTAATTGTACACCATGATATTGGTGGTATTTATGCTGTTAAGTCCAAACCTTTATCTGTCTGTTATTCTTAATGTT

>14805_14805_3_CDC27-HLF_CDC27_chr17_45258928_ENST00000531206_HLF_chr17_53345112_ENST00000226067_length(amino acids)=291AA_BP=34
MTVLQEPVQAAIWQALNHYAYRDAVFLAERLYAEAFSKDKDKEKKLDDESNSPTVPQSAFLGPTLWDKTLPYDGDTFQLEYMDLEEFLSE
NGIPPSPSQHDHSPHPPGLQPASSAAPSVMDLSSRASAPLHPGIPSPNCMQSPIRPGQLLPANRNTPSPIDPDTIQVPVGYEPDPADLAL
SSIPGQEMFDPRKRKFSEEELKPQPMIKKARKVFIPDDLKDDKYWARRRKNNMAAKRSRDARRLKENQIAIRASFLEKENSALRQEVADL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CDC27-HLF


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDC27-HLF


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDC27-HLF


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDC27C0033578Prostatic Neoplasms1CTD_human
HgeneCDC27C0376358Malignant neoplasm of prostate1CTD_human
TgeneC0006413Burkitt Lymphoma1ORPHANET
TgeneC0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
TgeneC0023453L2 Acute Lymphoblastic Leukemia1CTD_human
TgeneC0041696Unipolar Depression1PSYGENET
TgeneC1269683Major Depressive Disorder1PSYGENET
TgeneC1292769Precursor B-cell lymphoblastic leukemia1ORPHANET
TgeneC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human