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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDC42-LDLRAD2 (FusionGDB2 ID:HG998TG401944)

Fusion Gene Summary for CDC42-LDLRAD2

check button Fusion gene summary
Fusion gene informationFusion gene name: CDC42-LDLRAD2
Fusion gene ID: hg998tg401944
HgeneTgene
Gene symbol

CDC42

LDLRAD2

Gene ID

998

401944

Gene namecell division cycle 42low density lipoprotein receptor class A domain containing 2
SynonymsCDC42Hs|G25K|TKS-
Cytomap('CDC42')('LDLRAD2')

1p36.12

1p36.12

Type of geneprotein-codingprotein-coding
Descriptioncell division control protein 42 homologG25K GTP-binding proteinGTP binding protein, 25kDadJ224A6.1.1 (cell division cycle 42 (GTP-binding protein, 25kD))dJ224A6.1.2 (cell division cycle 42 (GTP-binding protein, 25kD))growth-regulating proteinsmall low-density lipoprotein receptor class A domain-containing protein 2low density lipoprotein receptor A domain containing 2
Modification date2020032720200313
UniProtAcc

P60953

Q5SZI1

Ensembl transtripts involved in fusion geneENST00000498236, ENST00000315554, 
ENST00000344548, ENST00000400259, 
ENST00000421089, 
Fusion gene scores* DoF score12 X 9 X 6=6482 X 3 X 3=18
# samples 133
** MAII scorelog2(13/648*10)=-2.31748218985617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context

PubMed: CDC42 [Title/Abstract] AND LDLRAD2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDC42(22379235)-LDLRAD2(22138843), # samples:2
Anticipated loss of major functional domain due to fusion event.CDC42-LDLRAD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC42-LDLRAD2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC42-LDLRAD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
CDC42-LDLRAD2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDC42

GO:0030036

actin cytoskeleton organization

11035016

HgeneCDC42

GO:0031274

positive regulation of pseudopodium assembly

11035016

HgeneCDC42

GO:0051489

regulation of filopodium assembly

14978216

HgeneCDC42

GO:1900026

positive regulation of substrate adhesion-dependent cell spreading

11807099


check buttonFusion gene breakpoints across CDC42 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across LDLRAD2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4OVTCGA-13-1405-01ACDC42chr1

22408287

+LDLRAD2chr1

22147943

+
ChimerDB4UCSTCGA-N7-A59BCDC42chr1

22379235

+LDLRAD2chr1

22138843

+
ChimerDB4UCSTCGA-N8-A4POCDC42chr1

22379235

+LDLRAD2chr1

22138843

+


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Fusion Gene ORF analysis for CDC42-LDLRAD2

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000498236ENST00000344642CDC42chr1

22408287

+LDLRAD2chr1

22147943

+
3UTR-3CDSENST00000498236ENST00000543870CDC42chr1

22408287

+LDLRAD2chr1

22147943

+
3UTR-5UTRENST00000498236ENST00000344642CDC42chr1

22379235

+LDLRAD2chr1

22138843

+
3UTR-intronENST00000498236ENST00000484271CDC42chr1

22408287

+LDLRAD2chr1

22147943

+
3UTR-intronENST00000498236ENST00000484271CDC42chr1

22379235

+LDLRAD2chr1

22138843

+
3UTR-intronENST00000498236ENST00000543870CDC42chr1

22379235

+LDLRAD2chr1

22138843

+
5CDS-intronENST00000315554ENST00000484271CDC42chr1

22408287

+LDLRAD2chr1

22147943

+
5CDS-intronENST00000344548ENST00000484271CDC42chr1

22408287

+LDLRAD2chr1

22147943

+
5CDS-intronENST00000400259ENST00000484271CDC42chr1

22408287

+LDLRAD2chr1

22147943

+
5CDS-intronENST00000421089ENST00000484271CDC42chr1

22408287

+LDLRAD2chr1

22147943

+
5UTR-5UTRENST00000315554ENST00000344642CDC42chr1

22379235

+LDLRAD2chr1

22138843

+
5UTR-5UTRENST00000344548ENST00000344642CDC42chr1

22379235

+LDLRAD2chr1

22138843

+
5UTR-5UTRENST00000400259ENST00000344642CDC42chr1

22379235

+LDLRAD2chr1

22138843

+
5UTR-5UTRENST00000421089ENST00000344642CDC42chr1

22379235

+LDLRAD2chr1

22138843

+
5UTR-intronENST00000315554ENST00000484271CDC42chr1

22379235

+LDLRAD2chr1

22138843

+
5UTR-intronENST00000315554ENST00000543870CDC42chr1

22379235

+LDLRAD2chr1

22138843

+
5UTR-intronENST00000344548ENST00000484271CDC42chr1

22379235

+LDLRAD2chr1

22138843

+
5UTR-intronENST00000344548ENST00000543870CDC42chr1

22379235

+LDLRAD2chr1

22138843

+
5UTR-intronENST00000400259ENST00000484271CDC42chr1

22379235

+LDLRAD2chr1

22138843

+
5UTR-intronENST00000400259ENST00000543870CDC42chr1

22379235

+LDLRAD2chr1

22138843

+
5UTR-intronENST00000421089ENST00000484271CDC42chr1

22379235

+LDLRAD2chr1

22138843

+
5UTR-intronENST00000421089ENST00000543870CDC42chr1

22379235

+LDLRAD2chr1

22138843

+
In-frameENST00000315554ENST00000344642CDC42chr1

22408287

+LDLRAD2chr1

22147943

+
In-frameENST00000315554ENST00000543870CDC42chr1

22408287

+LDLRAD2chr1

22147943

+
In-frameENST00000344548ENST00000344642CDC42chr1

22408287

+LDLRAD2chr1

22147943

+
In-frameENST00000344548ENST00000543870CDC42chr1

22408287

+LDLRAD2chr1

22147943

+
In-frameENST00000400259ENST00000344642CDC42chr1

22408287

+LDLRAD2chr1

22147943

+
In-frameENST00000400259ENST00000543870CDC42chr1

22408287

+LDLRAD2chr1

22147943

+
In-frameENST00000421089ENST00000344642CDC42chr1

22408287

+LDLRAD2chr1

22147943

+
In-frameENST00000421089ENST00000543870CDC42chr1

22408287

+LDLRAD2chr1

22147943

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000400259CDC42chr122408287+ENST00000344642LDLRAD2chr122147943+352634431312421236
ENST00000400259CDC42chr122408287+ENST00000543870LDLRAD2chr122147943+792344660160166
ENST00000344548CDC42chr122408287+ENST00000344642LDLRAD2chr122147943+361142932162506236
ENST00000344548CDC42chr122408287+ENST00000543870LDLRAD2chr122147943+877429251604117
ENST00000315554CDC42chr122408287+ENST00000344642LDLRAD2chr122147943+346428230692359236
ENST00000315554CDC42chr122408287+ENST00000543870LDLRAD2chr122147943+730282104457117
ENST00000421089CDC42chr122408287+ENST00000344642LDLRAD2chr122147943+361843632232513236
ENST00000421089CDC42chr122408287+ENST00000543870LDLRAD2chr122147943+884436132611159

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000400259ENST00000344642CDC42chr122408287+LDLRAD2chr122147943+0.50031740.4996826
ENST00000400259ENST00000543870CDC42chr122408287+LDLRAD2chr122147943+0.0253170340.974683
ENST00000344548ENST00000344642CDC42chr122408287+LDLRAD2chr122147943+0.465470140.53452986
ENST00000344548ENST00000543870CDC42chr122408287+LDLRAD2chr122147943+0.0136589430.98634106
ENST00000315554ENST00000344642CDC42chr122408287+LDLRAD2chr122147943+0.480213520.5197865
ENST00000315554ENST00000543870CDC42chr122408287+LDLRAD2chr122147943+0.0150214630.9849785
ENST00000421089ENST00000344642CDC42chr122408287+LDLRAD2chr122147943+0.492277560.5077225
ENST00000421089ENST00000543870CDC42chr122408287+LDLRAD2chr122147943+0.027692020.97230804

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Fusion Genomic Features for CDC42-LDLRAD2


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CDC42chr122408287+LDLRAD2chr122147942+0.0001866160.9998134
CDC42chr122408287+LDLRAD2chr122147942+0.0001866160.9998134

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CDC42-LDLRAD2


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:22379235/chr1:22138843)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
CDC42

P60953

LDLRAD2

Q5SZI1

FUNCTION: Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase (PubMed:15642749). Regulates cell migration (PubMed:17038317). In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections (PubMed:14978216). Required for DOCK10-mediated spine formation in Purkinje cells and hippocampal neurons. Facilitates filopodia formation upon DOCK11-activation (By similarity). Upon activation by CaMKII, modulates dendritic spine structural plasticity by relaying CaMKII transient activation to synapse-specific, long-term signaling (By similarity). Also plays a role in phagocytosis through organization of the F-actin cytoskeleton associated with forming phagocytic cups (PubMed:26465210). {ECO:0000250|UniProtKB:P60766, ECO:0000250|UniProtKB:Q8CFN2, ECO:0000269|PubMed:14978216, ECO:0000269|PubMed:15642749, ECO:0000269|PubMed:17038317, ECO:0000269|PubMed:26465210}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDC42chr1:22408287chr1:22147943ENST00000315554+3632_4059192.0MotifEffector region
HgeneCDC42chr1:22408287chr1:22147943ENST00000344548+4732_4059192.0MotifEffector region
HgeneCDC42chr1:22408287chr1:22147943ENST00000400259+3632_4059192.0MotifEffector region
HgeneCDC42chr1:22408287chr1:22147943ENST00000315554+3610_1759192.0Nucleotide bindingNote=GTP
HgeneCDC42chr1:22408287chr1:22147943ENST00000315554+3657_6159192.0Nucleotide bindingGTP
HgeneCDC42chr1:22408287chr1:22147943ENST00000344548+4710_1759192.0Nucleotide bindingNote=GTP
HgeneCDC42chr1:22408287chr1:22147943ENST00000344548+4757_6159192.0Nucleotide bindingGTP
HgeneCDC42chr1:22408287chr1:22147943ENST00000400259+3610_1759192.0Nucleotide bindingNote=GTP
HgeneCDC42chr1:22408287chr1:22147943ENST00000400259+3657_6159192.0Nucleotide bindingGTP
TgeneLDLRAD2chr1:22408287chr1:22147943ENST0000034464225251_272214273.0Topological domainCytoplasmic
TgeneLDLRAD2chr1:22408287chr1:22147943ENST0000054387026251_272214233.0Topological domainCytoplasmic
TgeneLDLRAD2chr1:22408287chr1:22147943ENST0000034464225234_250214273.0TransmembraneHelical
TgeneLDLRAD2chr1:22408287chr1:22147943ENST0000054387026234_250214233.0TransmembraneHelical

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDC42chr1:22408287chr1:22147943ENST00000315554+36115_11859192.0Nucleotide bindingNote=GTP
HgeneCDC42chr1:22408287chr1:22147943ENST00000344548+47115_11859192.0Nucleotide bindingNote=GTP
HgeneCDC42chr1:22408287chr1:22147943ENST00000400259+36115_11859192.0Nucleotide bindingNote=GTP
TgeneLDLRAD2chr1:22408287chr1:22147943ENST0000034464225172_214214273.0DomainLDL-receptor class A
TgeneLDLRAD2chr1:22408287chr1:22147943ENST0000054387026172_214214233.0DomainLDL-receptor class A
TgeneLDLRAD2chr1:22408287chr1:22147943ENST000003446422526_233214273.0Topological domainExtracellular
TgeneLDLRAD2chr1:22408287chr1:22147943ENST000005438702626_233214233.0Topological domainExtracellular


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Fusion Gene Sequence for CDC42-LDLRAD2


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>14898_14898_1_CDC42-LDLRAD2_CDC42_chr1_22408287_ENST00000315554_LDLRAD2_chr1_22147943_ENST00000344642_length(transcript)=3464nt_BP=282nt
GGCAGCCGAGGAGACCCCGCGCAGTGCTGCCAACGCCCCGGTGGAGAAGCTGAGGTCATCATCAGATTTGAAATATTTAAAGTGGATACA
AAACTATTTCAGCAATGCAGACAATTAAGTGTGTTGTTGTGGGCGATGGTGCTGTTGGTAAAACATGTCTCCTGATATCCTACACAACAA
ACAAATTTCCATCGGAATATGTACCGACTGTTTTTGACAACTATGCAGTCACAGTTATGATTGGTGGAGAACCATATACTCTTGGACTTT
TTGATACTGCAGGTCCCTCTCCGGTGCCCAGCCAGACAGGAAGTACAGATGCCCATACCTCCAGATCCCTGACTCCCTCCCCAGCTCTCG
GGTCTGCAGGATCCCTCTGGATTGCAGCTGAGAGGAGTTCCCCAGCAGGCAGGGACCCCACGAGACAAGACGCAGCTTTGGAAGGCTCCA
CTGAGTGAAGCCCTCATCAAAGACTCAGGAGGCCCCTGGCGGGGATAGCACCGTTTATTAAGAAAAATCAAGACAAAGACCACAGGAGGG
TCCCTTCTAGGACACAGAGGCCAGGCGTCCCAACCCCACAGTCTGGGGGCCACTGGCAGGATGGCACTTGAGCTGGATCTTCAGGCTCCT
GCAGATGGGGCAGGGTGGTCATATCCCCCTCCTCTCTCTCTCAGTCGTGAGTCCTGCCTTCCCCCACCTAAGGCACTAGCTCTTCCTGAG
CACCAGCGGCATCCGTCCGTCCGTTGTCTGTTGGAGGAGTCCCTGGGCCTTCACTTCCAGATGGGTGGGGATGTGGCCTGGGGTGGGCGG
GGCCCGGTGGGCGGGGCCCTATCAGTGCTGGGCTCTGCCTGTAGCAGCTCCTGGTAAGAGTTGGGGTGGGCCTTCCCTTACAGCCCCTGA
GGGAGGGACCCCAGGCTGTGTGCTGGCAGGAGGGGGTGGGAATGCAGGCCAGGAGGACGTGGTAGGAGGGGGAGTCTGCCAGAGGAGGTG
CCAGGGGCTGGGTGGAGGTGGGTGGGGGTGCTGAAAAACGAGCTGGTGGGGATGGGGACCGCCTGCCCAGGGGTGAGCTGCCTTTTGCTC
CACAGCCGGCACTAAAGACAATTCCCAATCCTGAGTGGGTGGCAGAGACTCCTGCGATGCCCGTCTCAGGTAGCTGTGGGGCACCAGCCC
ACAAGCCGAGGTTGGCTCTCCTAGGAGTGAGAACTGCCCAAGGGCTGCAGAAACAGGCCACCCAGCTCTATCTGGGGGCTCCATCGGTGG
GTAGGGGGACAGTGGGGGCAGTTCTGGGCCCACCCAGCCACTGTTCCTGACCCCAAGTCCTGGTGACTTTCTGAGGTGCCCACTCCCATC
CAACCTGCCTTGCTGGCCAGCCTTGTGGCTTTGCCCAGCTGTGTGTGTGAGGGTGGCATGCCCACCTCCAGTCCAGCCCAGGGCGGTAGC
AGCAAAGCGTGGCATCGCCTCGGTTTCTTACAAAAATTCATAATAATATTAATAATAATATACTCGACATTGTCGGGCTGGGGCGTGGCC
CGGGAGTCCGTGTGGGGCAGGCAGGTGCCTACGAGGGGCAGGGGCGTGTGTTGGCCCCGGCCTGGGCGCGGTGCTGCAGGTCCAGGGGCT
GTGGGGGCGGGGCGCCGGGTCGGGCCGAGTGCAGCACCAGGTTCTTGACACAGCCTGTGATGCCTGAGGAGAATCTGCCCCCGGTCAGCG
TGGCCACGTCAGGGGCTCCGCCTGCCGGGAGGTGAGAGGACAGGGCCTGTGGGCTCCAGCAGCCCAGGAGGCGAGGAAGGCTGGGCGAGC
TCTAGCCCTAAGGGAGTGCCGTTCCTGCCCCTGCCCTGAGAAGGAGCCCCAGACTTACCGATGTAGACGCTGCCCTTGGCGTTGACTGCC
ACGTTGGGACCTGGGGACCGGCCGCTGACCAGCTCCTCACCGTCGACTTGGATGGAACCTCTGCGGCCCTCCCTGCAGTGGAACTGGGTC
AGGCCCCTTTCCACAAACTTCCTGGTCCTCCCCGGCCCCACGACAGAGTCCCCTCCCTCTGATATCGAGACTCCAGACTCAGAAGTCTGT
CCCTGTTTCCCAAGCTCTTTCTTTCCCCCGCTGAACGAGAGATCGGGCCCCACAAACACAGCTTCCTCATTTCTGCACCCAGGTTTCCTC
CCACTCCTGGGGCACTCGCCTGCCCCCAGCGGAGTTCAGTCCGAGATGGAAGCCCGAGCCCTGGCTGGTGGGTTCTCCCCTCCCCTGGCT
TCAAGTTCTGTCTCCACAGAGCTCAATACCTGCCTCTCTGCCCATGGTAGGGGGCGTCCTGCCCCACTCCAGAACGCTGGGCCCCATCCC
GAGTGCCCGGCAGGGTCCCTTACCGCAGTGCTGTCACCCGGTGCCACTCGCCGTCATTGATGGGGTCCTCAGAGACCAGGCGGGCCTCCC
CACTACCCAGCTGGTACCTGCAGTCATCCAGGCCCAAGAAGTATGAGCTGGGGCAGGACCGGGGGGTGGGGTGCTGGGACCAGGGAAGGG
AGAGGAAGGGCCAGGTGCCAGGACCTACCTGAAGACAAGGTGCCCGTCTTGAAGCCCGAGGCTGATGAAGTCCTTGCCTTGGCCGGCCTC
TCCCACCTCCTGCCAGGGAAGCACAGGGTCTCTGGGGTCCCCAGCCTGGAGAGCAGAGGCTGCCGAGGCCAGGGGGCTCTGCTTTCCCCT
CCCCCCACCACTCCGGCCACCAGGAAGCCAGCTTCCTGCCCCAGGAGCCCCAAGAGCCCAGCCGGATACCCACACTCACCACACCCTGCC
AGAGCAGGAGGCCACTGGCTGTGCTGGTCCGAACCTCCAGCTCGATGGTCTCGGGCACCTCGGGCAGGCTGCGGAGGAAGAGCGGGTGAG
GGGACAGAAGTCCCAGATTCCCATCCTCCCCATTAGGCCCATGGGCCCTTCCAATGCCAGTCTCACCTCCTGGAGAAGACATGGCCAGGG
AAGGCGAGGAAGCCATCATCGTGGAAATAGGCTCCGTACTGCCCAGGGGCATCTGTGGGAGAGAGGAGGGTGGTGCCATACCTGCTGCAT
CAGGCATCAAAATCCCCCGTCAGTTCCCCTGACCCCCACCTCCACGCCAACATGCAGGACTAGGGGGCTCCGAGCCTGCAGTCCCTGGGG
ACCCACGGGGGCTGCCAACAGAATTCAGGGAGCCTATGACCTTGGATGGGAAAGCATTACACCTCAATTTCACTCACTTCTCACTGAAAT
TGAGCAGTTCTTTCAATGAGATGTAGGCAAGAAACCAAAGTAGCAGTGGTAGGACCTGCAACTTTGTTACTAGTATTTGCTTATCACATG
ACAGTAGCTGCAAATATTTCAAAATATCATTTACACATATTGCTGCTTTGAAATTGTGGTAGCTACTGAGATCACCAGATCTTGTTATTT

>14898_14898_1_CDC42-LDLRAD2_CDC42_chr1_22408287_ENST00000315554_LDLRAD2_chr1_22147943_ENST00000344642_length(amino acids)=236AA_BP=
MMPDAAGMAPPSSLPQMPLGSTEPISTMMASSPSLAMSSPGGETGIGRAHGPNGEDGNLGLLSPHPLFLRSLPEVPETIELEVRTSTASG
LLLWQGVVSVGIRLGSWGSWGRKLASWWPEWWGEGKAEPPGLGSLCSPGWGPQRPCASLAGGGRGRPRQGLHQPRASRRAPCLQVGPGTW

--------------------------------------------------------------
>14898_14898_2_CDC42-LDLRAD2_CDC42_chr1_22408287_ENST00000315554_LDLRAD2_chr1_22147943_ENST00000543870_length(transcript)=730nt_BP=282nt
GGCAGCCGAGGAGACCCCGCGCAGTGCTGCCAACGCCCCGGTGGAGAAGCTGAGGTCATCATCAGATTTGAAATATTTAAAGTGGATACA
AAACTATTTCAGCAATGCAGACAATTAAGTGTGTTGTTGTGGGCGATGGTGCTGTTGGTAAAACATGTCTCCTGATATCCTACACAACAA
ACAAATTTCCATCGGAATATGTACCGACTGTTTTTGACAACTATGCAGTCACAGTTATGATTGGTGGAGAACCATATACTCTTGGACTTT
TTGATACTGCAGGTCCCTCTCCGGTGCCCAGCCAGACAGGAAGTACAGATGCCCATACCTCCAGATCCCTGACTCCCTCCCCAGCTCTCG
GGTCTGCAGGATCCCTCTGGATTGCAGCTGAGAGGAGTTCCCCAGCAGGCAGGGACCCCACGAGACAAGACGCAGCTTTGGAAGGCTCCA
CTGAGTGAAGCCCTCATCAAAGACTCAGGAGGCCCCTGGCGGGGATAGCACCGTTTATTAAGAAAAATCAAGACAAAGACCACAGGAGGG
TCCCTTCTAGGACACAGAGGCCAGGCGTCCCAACCCCACAGTCTGGGGGCCACTGGCAGGATGGCACTTGAGCTGGATCTTCAGGCTCCT
GCAGATGGGGCAGGGTGGTCATATCCCCCTCCTCTCTCTCTCAGTCGTTTCCTCCCACTCCTGGGGCACTCGCCTGCCCCCAGCGGAGTT

>14898_14898_2_CDC42-LDLRAD2_CDC42_chr1_22408287_ENST00000315554_LDLRAD2_chr1_22147943_ENST00000543870_length(amino acids)=117AA_BP=58
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGPSPVPSQTGSTDAHTSRSLTPSPALGSAGS

--------------------------------------------------------------
>14898_14898_3_CDC42-LDLRAD2_CDC42_chr1_22408287_ENST00000344548_LDLRAD2_chr1_22147943_ENST00000344642_length(transcript)=3611nt_BP=429nt
GTCAGGTGCGTGCCCCTGTCCGGCAGCCGAGGAGACCCCGCGCAGTGCTGCCAACGCCCCGGTGGAGAAGCTGAGACGGAGTCTCACTGT
GTTGCCCAGGCTGGAGTGCAGTGGCGCCATCTTGGCTCACTGCAGTGCGCCTCTGCCCCCCGAGTTCAAGCGATTCTCCTGCCTCAGGCT
CCTGAGTAGCTGGGACTACAGGTCATCATCAGATTTGAAATATTTAAAGTGGATACAAAACTATTTCAGCAATGCAGACAATTAAGTGTG
TTGTTGTGGGCGATGGTGCTGTTGGTAAAACATGTCTCCTGATATCCTACACAACAAACAAATTTCCATCGGAATATGTACCGACTGTTT
TTGACAACTATGCAGTCACAGTTATGATTGGTGGAGAACCATATACTCTTGGACTTTTTGATACTGCAGGTCCCTCTCCGGTGCCCAGCC
AGACAGGAAGTACAGATGCCCATACCTCCAGATCCCTGACTCCCTCCCCAGCTCTCGGGTCTGCAGGATCCCTCTGGATTGCAGCTGAGA
GGAGTTCCCCAGCAGGCAGGGACCCCACGAGACAAGACGCAGCTTTGGAAGGCTCCACTGAGTGAAGCCCTCATCAAAGACTCAGGAGGC
CCCTGGCGGGGATAGCACCGTTTATTAAGAAAAATCAAGACAAAGACCACAGGAGGGTCCCTTCTAGGACACAGAGGCCAGGCGTCCCAA
CCCCACAGTCTGGGGGCCACTGGCAGGATGGCACTTGAGCTGGATCTTCAGGCTCCTGCAGATGGGGCAGGGTGGTCATATCCCCCTCCT
CTCTCTCTCAGTCGTGAGTCCTGCCTTCCCCCACCTAAGGCACTAGCTCTTCCTGAGCACCAGCGGCATCCGTCCGTCCGTTGTCTGTTG
GAGGAGTCCCTGGGCCTTCACTTCCAGATGGGTGGGGATGTGGCCTGGGGTGGGCGGGGCCCGGTGGGCGGGGCCCTATCAGTGCTGGGC
TCTGCCTGTAGCAGCTCCTGGTAAGAGTTGGGGTGGGCCTTCCCTTACAGCCCCTGAGGGAGGGACCCCAGGCTGTGTGCTGGCAGGAGG
GGGTGGGAATGCAGGCCAGGAGGACGTGGTAGGAGGGGGAGTCTGCCAGAGGAGGTGCCAGGGGCTGGGTGGAGGTGGGTGGGGGTGCTG
AAAAACGAGCTGGTGGGGATGGGGACCGCCTGCCCAGGGGTGAGCTGCCTTTTGCTCCACAGCCGGCACTAAAGACAATTCCCAATCCTG
AGTGGGTGGCAGAGACTCCTGCGATGCCCGTCTCAGGTAGCTGTGGGGCACCAGCCCACAAGCCGAGGTTGGCTCTCCTAGGAGTGAGAA
CTGCCCAAGGGCTGCAGAAACAGGCCACCCAGCTCTATCTGGGGGCTCCATCGGTGGGTAGGGGGACAGTGGGGGCAGTTCTGGGCCCAC
CCAGCCACTGTTCCTGACCCCAAGTCCTGGTGACTTTCTGAGGTGCCCACTCCCATCCAACCTGCCTTGCTGGCCAGCCTTGTGGCTTTG
CCCAGCTGTGTGTGTGAGGGTGGCATGCCCACCTCCAGTCCAGCCCAGGGCGGTAGCAGCAAAGCGTGGCATCGCCTCGGTTTCTTACAA
AAATTCATAATAATATTAATAATAATATACTCGACATTGTCGGGCTGGGGCGTGGCCCGGGAGTCCGTGTGGGGCAGGCAGGTGCCTACG
AGGGGCAGGGGCGTGTGTTGGCCCCGGCCTGGGCGCGGTGCTGCAGGTCCAGGGGCTGTGGGGGCGGGGCGCCGGGTCGGGCCGAGTGCA
GCACCAGGTTCTTGACACAGCCTGTGATGCCTGAGGAGAATCTGCCCCCGGTCAGCGTGGCCACGTCAGGGGCTCCGCCTGCCGGGAGGT
GAGAGGACAGGGCCTGTGGGCTCCAGCAGCCCAGGAGGCGAGGAAGGCTGGGCGAGCTCTAGCCCTAAGGGAGTGCCGTTCCTGCCCCTG
CCCTGAGAAGGAGCCCCAGACTTACCGATGTAGACGCTGCCCTTGGCGTTGACTGCCACGTTGGGACCTGGGGACCGGCCGCTGACCAGC
TCCTCACCGTCGACTTGGATGGAACCTCTGCGGCCCTCCCTGCAGTGGAACTGGGTCAGGCCCCTTTCCACAAACTTCCTGGTCCTCCCC
GGCCCCACGACAGAGTCCCCTCCCTCTGATATCGAGACTCCAGACTCAGAAGTCTGTCCCTGTTTCCCAAGCTCTTTCTTTCCCCCGCTG
AACGAGAGATCGGGCCCCACAAACACAGCTTCCTCATTTCTGCACCCAGGTTTCCTCCCACTCCTGGGGCACTCGCCTGCCCCCAGCGGA
GTTCAGTCCGAGATGGAAGCCCGAGCCCTGGCTGGTGGGTTCTCCCCTCCCCTGGCTTCAAGTTCTGTCTCCACAGAGCTCAATACCTGC
CTCTCTGCCCATGGTAGGGGGCGTCCTGCCCCACTCCAGAACGCTGGGCCCCATCCCGAGTGCCCGGCAGGGTCCCTTACCGCAGTGCTG
TCACCCGGTGCCACTCGCCGTCATTGATGGGGTCCTCAGAGACCAGGCGGGCCTCCCCACTACCCAGCTGGTACCTGCAGTCATCCAGGC
CCAAGAAGTATGAGCTGGGGCAGGACCGGGGGGTGGGGTGCTGGGACCAGGGAAGGGAGAGGAAGGGCCAGGTGCCAGGACCTACCTGAA
GACAAGGTGCCCGTCTTGAAGCCCGAGGCTGATGAAGTCCTTGCCTTGGCCGGCCTCTCCCACCTCCTGCCAGGGAAGCACAGGGTCTCT
GGGGTCCCCAGCCTGGAGAGCAGAGGCTGCCGAGGCCAGGGGGCTCTGCTTTCCCCTCCCCCCACCACTCCGGCCACCAGGAAGCCAGCT
TCCTGCCCCAGGAGCCCCAAGAGCCCAGCCGGATACCCACACTCACCACACCCTGCCAGAGCAGGAGGCCACTGGCTGTGCTGGTCCGAA
CCTCCAGCTCGATGGTCTCGGGCACCTCGGGCAGGCTGCGGAGGAAGAGCGGGTGAGGGGACAGAAGTCCCAGATTCCCATCCTCCCCAT
TAGGCCCATGGGCCCTTCCAATGCCAGTCTCACCTCCTGGAGAAGACATGGCCAGGGAAGGCGAGGAAGCCATCATCGTGGAAATAGGCT
CCGTACTGCCCAGGGGCATCTGTGGGAGAGAGGAGGGTGGTGCCATACCTGCTGCATCAGGCATCAAAATCCCCCGTCAGTTCCCCTGAC
CCCCACCTCCACGCCAACATGCAGGACTAGGGGGCTCCGAGCCTGCAGTCCCTGGGGACCCACGGGGGCTGCCAACAGAATTCAGGGAGC
CTATGACCTTGGATGGGAAAGCATTACACCTCAATTTCACTCACTTCTCACTGAAATTGAGCAGTTCTTTCAATGAGATGTAGGCAAGAA
ACCAAAGTAGCAGTGGTAGGACCTGCAACTTTGTTACTAGTATTTGCTTATCACATGACAGTAGCTGCAAATATTTCAAAATATCATTTA
CACATATTGCTGCTTTGAAATTGTGGTAGCTACTGAGATCACCAGATCTTGTTATTTGATGTGTTAATAAAGAAGCACATATATAGCAAG

>14898_14898_3_CDC42-LDLRAD2_CDC42_chr1_22408287_ENST00000344548_LDLRAD2_chr1_22147943_ENST00000344642_length(amino acids)=236AA_BP=
MMPDAAGMAPPSSLPQMPLGSTEPISTMMASSPSLAMSSPGGETGIGRAHGPNGEDGNLGLLSPHPLFLRSLPEVPETIELEVRTSTASG
LLLWQGVVSVGIRLGSWGSWGRKLASWWPEWWGEGKAEPPGLGSLCSPGWGPQRPCASLAGGGRGRPRQGLHQPRASRRAPCLQVGPGTW

--------------------------------------------------------------
>14898_14898_4_CDC42-LDLRAD2_CDC42_chr1_22408287_ENST00000344548_LDLRAD2_chr1_22147943_ENST00000543870_length(transcript)=877nt_BP=429nt
GTCAGGTGCGTGCCCCTGTCCGGCAGCCGAGGAGACCCCGCGCAGTGCTGCCAACGCCCCGGTGGAGAAGCTGAGACGGAGTCTCACTGT
GTTGCCCAGGCTGGAGTGCAGTGGCGCCATCTTGGCTCACTGCAGTGCGCCTCTGCCCCCCGAGTTCAAGCGATTCTCCTGCCTCAGGCT
CCTGAGTAGCTGGGACTACAGGTCATCATCAGATTTGAAATATTTAAAGTGGATACAAAACTATTTCAGCAATGCAGACAATTAAGTGTG
TTGTTGTGGGCGATGGTGCTGTTGGTAAAACATGTCTCCTGATATCCTACACAACAAACAAATTTCCATCGGAATATGTACCGACTGTTT
TTGACAACTATGCAGTCACAGTTATGATTGGTGGAGAACCATATACTCTTGGACTTTTTGATACTGCAGGTCCCTCTCCGGTGCCCAGCC
AGACAGGAAGTACAGATGCCCATACCTCCAGATCCCTGACTCCCTCCCCAGCTCTCGGGTCTGCAGGATCCCTCTGGATTGCAGCTGAGA
GGAGTTCCCCAGCAGGCAGGGACCCCACGAGACAAGACGCAGCTTTGGAAGGCTCCACTGAGTGAAGCCCTCATCAAAGACTCAGGAGGC
CCCTGGCGGGGATAGCACCGTTTATTAAGAAAAATCAAGACAAAGACCACAGGAGGGTCCCTTCTAGGACACAGAGGCCAGGCGTCCCAA
CCCCACAGTCTGGGGGCCACTGGCAGGATGGCACTTGAGCTGGATCTTCAGGCTCCTGCAGATGGGGCAGGGTGGTCATATCCCCCTCCT

>14898_14898_4_CDC42-LDLRAD2_CDC42_chr1_22408287_ENST00000344548_LDLRAD2_chr1_22147943_ENST00000543870_length(amino acids)=117AA_BP=58
MQTIKCVVVGDGAVGKTCLLISYTTNKFPSEYVPTVFDNYAVTVMIGGEPYTLGLFDTAGPSPVPSQTGSTDAHTSRSLTPSPALGSAGS

--------------------------------------------------------------
>14898_14898_5_CDC42-LDLRAD2_CDC42_chr1_22408287_ENST00000400259_LDLRAD2_chr1_22147943_ENST00000344642_length(transcript)=3526nt_BP=344nt
ACTTCCGCGGGCACCCAACTGTGCGTCTCCTGCGCGCTGACGTCAGGTGCGTGCCCCTGTCCGGCAGCCGAGGAGACCCCGCGCAGTGCT
GCCAACGCCCCGGTGGAGAAGCTGAGGTCATCATCAGATTTGAAATATTTAAAGTGGATACAAAACTATTTCAGCAATGCAGACAATTAA
GTGTGTTGTTGTGGGCGATGGTGCTGTTGGTAAAACATGTCTCCTGATATCCTACACAACAAACAAATTTCCATCGGAATATGTACCGAC
TGTTTTTGACAACTATGCAGTCACAGTTATGATTGGTGGAGAACCATATACTCTTGGACTTTTTGATACTGCAGGTCCCTCTCCGGTGCC
CAGCCAGACAGGAAGTACAGATGCCCATACCTCCAGATCCCTGACTCCCTCCCCAGCTCTCGGGTCTGCAGGATCCCTCTGGATTGCAGC
TGAGAGGAGTTCCCCAGCAGGCAGGGACCCCACGAGACAAGACGCAGCTTTGGAAGGCTCCACTGAGTGAAGCCCTCATCAAAGACTCAG
GAGGCCCCTGGCGGGGATAGCACCGTTTATTAAGAAAAATCAAGACAAAGACCACAGGAGGGTCCCTTCTAGGACACAGAGGCCAGGCGT
CCCAACCCCACAGTCTGGGGGCCACTGGCAGGATGGCACTTGAGCTGGATCTTCAGGCTCCTGCAGATGGGGCAGGGTGGTCATATCCCC
CTCCTCTCTCTCTCAGTCGTGAGTCCTGCCTTCCCCCACCTAAGGCACTAGCTCTTCCTGAGCACCAGCGGCATCCGTCCGTCCGTTGTC
TGTTGGAGGAGTCCCTGGGCCTTCACTTCCAGATGGGTGGGGATGTGGCCTGGGGTGGGCGGGGCCCGGTGGGCGGGGCCCTATCAGTGC
TGGGCTCTGCCTGTAGCAGCTCCTGGTAAGAGTTGGGGTGGGCCTTCCCTTACAGCCCCTGAGGGAGGGACCCCAGGCTGTGTGCTGGCA
GGAGGGGGTGGGAATGCAGGCCAGGAGGACGTGGTAGGAGGGGGAGTCTGCCAGAGGAGGTGCCAGGGGCTGGGTGGAGGTGGGTGGGGG
TGCTGAAAAACGAGCTGGTGGGGATGGGGACCGCCTGCCCAGGGGTGAGCTGCCTTTTGCTCCACAGCCGGCACTAAAGACAATTCCCAA
TCCTGAGTGGGTGGCAGAGACTCCTGCGATGCCCGTCTCAGGTAGCTGTGGGGCACCAGCCCACAAGCCGAGGTTGGCTCTCCTAGGAGT
GAGAACTGCCCAAGGGCTGCAGAAACAGGCCACCCAGCTCTATCTGGGGGCTCCATCGGTGGGTAGGGGGACAGTGGGGGCAGTTCTGGG
CCCACCCAGCCACTGTTCCTGACCCCAAGTCCTGGTGACTTTCTGAGGTGCCCACTCCCATCCAACCTGCCTTGCTGGCCAGCCTTGTGG
CTTTGCCCAGCTGTGTGTGTGAGGGTGGCATGCCCACCTCCAGTCCAGCCCAGGGCGGTAGCAGCAAAGCGTGGCATCGCCTCGGTTTCT
TACAAAAATTCATAATAATATTAATAATAATATACTCGACATTGTCGGGCTGGGGCGTGGCCCGGGAGTCCGTGTGGGGCAGGCAGGTGC
CTACGAGGGGCAGGGGCGTGTGTTGGCCCCGGCCTGGGCGCGGTGCTGCAGGTCCAGGGGCTGTGGGGGCGGGGCGCCGGGTCGGGCCGA
GTGCAGCACCAGGTTCTTGACACAGCCTGTGATGCCTGAGGAGAATCTGCCCCCGGTCAGCGTGGCCACGTCAGGGGCTCCGCCTGCCGG
GAGGTGAGAGGACAGGGCCTGTGGGCTCCAGCAGCCCAGGAGGCGAGGAAGGCTGGGCGAGCTCTAGCCCTAAGGGAGTGCCGTTCCTGC
CCCTGCCCTGAGAAGGAGCCCCAGACTTACCGATGTAGACGCTGCCCTTGGCGTTGACTGCCACGTTGGGACCTGGGGACCGGCCGCTGA
CCAGCTCCTCACCGTCGACTTGGATGGAACCTCTGCGGCCCTCCCTGCAGTGGAACTGGGTCAGGCCCCTTTCCACAAACTTCCTGGTCC
TCCCCGGCCCCACGACAGAGTCCCCTCCCTCTGATATCGAGACTCCAGACTCAGAAGTCTGTCCCTGTTTCCCAAGCTCTTTCTTTCCCC
CGCTGAACGAGAGATCGGGCCCCACAAACACAGCTTCCTCATTTCTGCACCCAGGTTTCCTCCCACTCCTGGGGCACTCGCCTGCCCCCA
GCGGAGTTCAGTCCGAGATGGAAGCCCGAGCCCTGGCTGGTGGGTTCTCCCCTCCCCTGGCTTCAAGTTCTGTCTCCACAGAGCTCAATA
CCTGCCTCTCTGCCCATGGTAGGGGGCGTCCTGCCCCACTCCAGAACGCTGGGCCCCATCCCGAGTGCCCGGCAGGGTCCCTTACCGCAG
TGCTGTCACCCGGTGCCACTCGCCGTCATTGATGGGGTCCTCAGAGACCAGGCGGGCCTCCCCACTACCCAGCTGGTACCTGCAGTCATC
CAGGCCCAAGAAGTATGAGCTGGGGCAGGACCGGGGGGTGGGGTGCTGGGACCAGGGAAGGGAGAGGAAGGGCCAGGTGCCAGGACCTAC
CTGAAGACAAGGTGCCCGTCTTGAAGCCCGAGGCTGATGAAGTCCTTGCCTTGGCCGGCCTCTCCCACCTCCTGCCAGGGAAGCACAGGG
TCTCTGGGGTCCCCAGCCTGGAGAGCAGAGGCTGCCGAGGCCAGGGGGCTCTGCTTTCCCCTCCCCCCACCACTCCGGCCACCAGGAAGC
CAGCTTCCTGCCCCAGGAGCCCCAAGAGCCCAGCCGGATACCCACACTCACCACACCCTGCCAGAGCAGGAGGCCACTGGCTGTGCTGGT
CCGAACCTCCAGCTCGATGGTCTCGGGCACCTCGGGCAGGCTGCGGAGGAAGAGCGGGTGAGGGGACAGAAGTCCCAGATTCCCATCCTC
CCCATTAGGCCCATGGGCCCTTCCAATGCCAGTCTCACCTCCTGGAGAAGACATGGCCAGGGAAGGCGAGGAAGCCATCATCGTGGAAAT
AGGCTCCGTACTGCCCAGGGGCATCTGTGGGAGAGAGGAGGGTGGTGCCATACCTGCTGCATCAGGCATCAAAATCCCCCGTCAGTTCCC
CTGACCCCCACCTCCACGCCAACATGCAGGACTAGGGGGCTCCGAGCCTGCAGTCCCTGGGGACCCACGGGGGCTGCCAACAGAATTCAG
GGAGCCTATGACCTTGGATGGGAAAGCATTACACCTCAATTTCACTCACTTCTCACTGAAATTGAGCAGTTCTTTCAATGAGATGTAGGC
AAGAAACCAAAGTAGCAGTGGTAGGACCTGCAACTTTGTTACTAGTATTTGCTTATCACATGACAGTAGCTGCAAATATTTCAAAATATC
ATTTACACATATTGCTGCTTTGAAATTGTGGTAGCTACTGAGATCACCAGATCTTGTTATTTGATGTGTTAATAAAGAAGCACATATATA

>14898_14898_5_CDC42-LDLRAD2_CDC42_chr1_22408287_ENST00000400259_LDLRAD2_chr1_22147943_ENST00000344642_length(amino acids)=236AA_BP=
MMPDAAGMAPPSSLPQMPLGSTEPISTMMASSPSLAMSSPGGETGIGRAHGPNGEDGNLGLLSPHPLFLRSLPEVPETIELEVRTSTASG
LLLWQGVVSVGIRLGSWGSWGRKLASWWPEWWGEGKAEPPGLGSLCSPGWGPQRPCASLAGGGRGRPRQGLHQPRASRRAPCLQVGPGTW

--------------------------------------------------------------
>14898_14898_6_CDC42-LDLRAD2_CDC42_chr1_22408287_ENST00000400259_LDLRAD2_chr1_22147943_ENST00000543870_length(transcript)=792nt_BP=344nt
ACTTCCGCGGGCACCCAACTGTGCGTCTCCTGCGCGCTGACGTCAGGTGCGTGCCCCTGTCCGGCAGCCGAGGAGACCCCGCGCAGTGCT
GCCAACGCCCCGGTGGAGAAGCTGAGGTCATCATCAGATTTGAAATATTTAAAGTGGATACAAAACTATTTCAGCAATGCAGACAATTAA
GTGTGTTGTTGTGGGCGATGGTGCTGTTGGTAAAACATGTCTCCTGATATCCTACACAACAAACAAATTTCCATCGGAATATGTACCGAC
TGTTTTTGACAACTATGCAGTCACAGTTATGATTGGTGGAGAACCATATACTCTTGGACTTTTTGATACTGCAGGTCCCTCTCCGGTGCC
CAGCCAGACAGGAAGTACAGATGCCCATACCTCCAGATCCCTGACTCCCTCCCCAGCTCTCGGGTCTGCAGGATCCCTCTGGATTGCAGC
TGAGAGGAGTTCCCCAGCAGGCAGGGACCCCACGAGACAAGACGCAGCTTTGGAAGGCTCCACTGAGTGAAGCCCTCATCAAAGACTCAG
GAGGCCCCTGGCGGGGATAGCACCGTTTATTAAGAAAAATCAAGACAAAGACCACAGGAGGGTCCCTTCTAGGACACAGAGGCCAGGCGT
CCCAACCCCACAGTCTGGGGGCCACTGGCAGGATGGCACTTGAGCTGGATCTTCAGGCTCCTGCAGATGGGGCAGGGTGGTCATATCCCC

>14898_14898_6_CDC42-LDLRAD2_CDC42_chr1_22408287_ENST00000400259_LDLRAD2_chr1_22147943_ENST00000543870_length(amino acids)=166AA_BP=1
MPVAPRLWGWDAWPLCPRRDPPVVFVLIFLNKRCYPRQGPPESLMRASLSGAFQSCVLSRGVPACWGTPLSCNPEGSCRPESWGGSQGSG

--------------------------------------------------------------
>14898_14898_7_CDC42-LDLRAD2_CDC42_chr1_22408287_ENST00000421089_LDLRAD2_chr1_22147943_ENST00000344642_length(transcript)=3618nt_BP=436nt
AGTGCTGCCAACGCCCCGGTGGAGAAGCTGAGGTCATCATCAGATTTGAAATATTTAAAGTGGATACAAAACTATTTCAGCAATGCAGAC
AATTAAGTGTGTTGTTGTGGGCGATGGTGCTGTTGGTAAAACATGTCTCCTGATATCCTACACAACAAACAAATTTCCATCGGAATATGT
ACCGACTATCTTGACTTCTCATGGGTAAATTATATACACTTTAAACAGCTGAAAAATCAGTGGAAAGTCAGAAGGGGTGACACAGGGTTT
GCAAGAAGTGCTGGGAGGCAAAACTCCAGTAGACAAGATTCTAACGAGTGGTGGTCTCAATTTGGTGAAGTATGCCCTACATCTTGGAAT
GAGGTTTTTGACAACTATGCAGTCACAGTTATGATTGGTGGAGAACCATATACTCTTGGACTTTTTGATACTGCAGGTCCCTCTCCGGTG
CCCAGCCAGACAGGAAGTACAGATGCCCATACCTCCAGATCCCTGACTCCCTCCCCAGCTCTCGGGTCTGCAGGATCCCTCTGGATTGCA
GCTGAGAGGAGTTCCCCAGCAGGCAGGGACCCCACGAGACAAGACGCAGCTTTGGAAGGCTCCACTGAGTGAAGCCCTCATCAAAGACTC
AGGAGGCCCCTGGCGGGGATAGCACCGTTTATTAAGAAAAATCAAGACAAAGACCACAGGAGGGTCCCTTCTAGGACACAGAGGCCAGGC
GTCCCAACCCCACAGTCTGGGGGCCACTGGCAGGATGGCACTTGAGCTGGATCTTCAGGCTCCTGCAGATGGGGCAGGGTGGTCATATCC
CCCTCCTCTCTCTCTCAGTCGTGAGTCCTGCCTTCCCCCACCTAAGGCACTAGCTCTTCCTGAGCACCAGCGGCATCCGTCCGTCCGTTG
TCTGTTGGAGGAGTCCCTGGGCCTTCACTTCCAGATGGGTGGGGATGTGGCCTGGGGTGGGCGGGGCCCGGTGGGCGGGGCCCTATCAGT
GCTGGGCTCTGCCTGTAGCAGCTCCTGGTAAGAGTTGGGGTGGGCCTTCCCTTACAGCCCCTGAGGGAGGGACCCCAGGCTGTGTGCTGG
CAGGAGGGGGTGGGAATGCAGGCCAGGAGGACGTGGTAGGAGGGGGAGTCTGCCAGAGGAGGTGCCAGGGGCTGGGTGGAGGTGGGTGGG
GGTGCTGAAAAACGAGCTGGTGGGGATGGGGACCGCCTGCCCAGGGGTGAGCTGCCTTTTGCTCCACAGCCGGCACTAAAGACAATTCCC
AATCCTGAGTGGGTGGCAGAGACTCCTGCGATGCCCGTCTCAGGTAGCTGTGGGGCACCAGCCCACAAGCCGAGGTTGGCTCTCCTAGGA
GTGAGAACTGCCCAAGGGCTGCAGAAACAGGCCACCCAGCTCTATCTGGGGGCTCCATCGGTGGGTAGGGGGACAGTGGGGGCAGTTCTG
GGCCCACCCAGCCACTGTTCCTGACCCCAAGTCCTGGTGACTTTCTGAGGTGCCCACTCCCATCCAACCTGCCTTGCTGGCCAGCCTTGT
GGCTTTGCCCAGCTGTGTGTGTGAGGGTGGCATGCCCACCTCCAGTCCAGCCCAGGGCGGTAGCAGCAAAGCGTGGCATCGCCTCGGTTT
CTTACAAAAATTCATAATAATATTAATAATAATATACTCGACATTGTCGGGCTGGGGCGTGGCCCGGGAGTCCGTGTGGGGCAGGCAGGT
GCCTACGAGGGGCAGGGGCGTGTGTTGGCCCCGGCCTGGGCGCGGTGCTGCAGGTCCAGGGGCTGTGGGGGCGGGGCGCCGGGTCGGGCC
GAGTGCAGCACCAGGTTCTTGACACAGCCTGTGATGCCTGAGGAGAATCTGCCCCCGGTCAGCGTGGCCACGTCAGGGGCTCCGCCTGCC
GGGAGGTGAGAGGACAGGGCCTGTGGGCTCCAGCAGCCCAGGAGGCGAGGAAGGCTGGGCGAGCTCTAGCCCTAAGGGAGTGCCGTTCCT
GCCCCTGCCCTGAGAAGGAGCCCCAGACTTACCGATGTAGACGCTGCCCTTGGCGTTGACTGCCACGTTGGGACCTGGGGACCGGCCGCT
GACCAGCTCCTCACCGTCGACTTGGATGGAACCTCTGCGGCCCTCCCTGCAGTGGAACTGGGTCAGGCCCCTTTCCACAAACTTCCTGGT
CCTCCCCGGCCCCACGACAGAGTCCCCTCCCTCTGATATCGAGACTCCAGACTCAGAAGTCTGTCCCTGTTTCCCAAGCTCTTTCTTTCC
CCCGCTGAACGAGAGATCGGGCCCCACAAACACAGCTTCCTCATTTCTGCACCCAGGTTTCCTCCCACTCCTGGGGCACTCGCCTGCCCC
CAGCGGAGTTCAGTCCGAGATGGAAGCCCGAGCCCTGGCTGGTGGGTTCTCCCCTCCCCTGGCTTCAAGTTCTGTCTCCACAGAGCTCAA
TACCTGCCTCTCTGCCCATGGTAGGGGGCGTCCTGCCCCACTCCAGAACGCTGGGCCCCATCCCGAGTGCCCGGCAGGGTCCCTTACCGC
AGTGCTGTCACCCGGTGCCACTCGCCGTCATTGATGGGGTCCTCAGAGACCAGGCGGGCCTCCCCACTACCCAGCTGGTACCTGCAGTCA
TCCAGGCCCAAGAAGTATGAGCTGGGGCAGGACCGGGGGGTGGGGTGCTGGGACCAGGGAAGGGAGAGGAAGGGCCAGGTGCCAGGACCT
ACCTGAAGACAAGGTGCCCGTCTTGAAGCCCGAGGCTGATGAAGTCCTTGCCTTGGCCGGCCTCTCCCACCTCCTGCCAGGGAAGCACAG
GGTCTCTGGGGTCCCCAGCCTGGAGAGCAGAGGCTGCCGAGGCCAGGGGGCTCTGCTTTCCCCTCCCCCCACCACTCCGGCCACCAGGAA
GCCAGCTTCCTGCCCCAGGAGCCCCAAGAGCCCAGCCGGATACCCACACTCACCACACCCTGCCAGAGCAGGAGGCCACTGGCTGTGCTG
GTCCGAACCTCCAGCTCGATGGTCTCGGGCACCTCGGGCAGGCTGCGGAGGAAGAGCGGGTGAGGGGACAGAAGTCCCAGATTCCCATCC
TCCCCATTAGGCCCATGGGCCCTTCCAATGCCAGTCTCACCTCCTGGAGAAGACATGGCCAGGGAAGGCGAGGAAGCCATCATCGTGGAA
ATAGGCTCCGTACTGCCCAGGGGCATCTGTGGGAGAGAGGAGGGTGGTGCCATACCTGCTGCATCAGGCATCAAAATCCCCCGTCAGTTC
CCCTGACCCCCACCTCCACGCCAACATGCAGGACTAGGGGGCTCCGAGCCTGCAGTCCCTGGGGACCCACGGGGGCTGCCAACAGAATTC
AGGGAGCCTATGACCTTGGATGGGAAAGCATTACACCTCAATTTCACTCACTTCTCACTGAAATTGAGCAGTTCTTTCAATGAGATGTAG
GCAAGAAACCAAAGTAGCAGTGGTAGGACCTGCAACTTTGTTACTAGTATTTGCTTATCACATGACAGTAGCTGCAAATATTTCAAAATA
TCATTTACACATATTGCTGCTTTGAAATTGTGGTAGCTACTGAGATCACCAGATCTTGTTATTTGATGTGTTAATAAAGAAGCACATATA

>14898_14898_7_CDC42-LDLRAD2_CDC42_chr1_22408287_ENST00000421089_LDLRAD2_chr1_22147943_ENST00000344642_length(amino acids)=236AA_BP=
MMPDAAGMAPPSSLPQMPLGSTEPISTMMASSPSLAMSSPGGETGIGRAHGPNGEDGNLGLLSPHPLFLRSLPEVPETIELEVRTSTASG
LLLWQGVVSVGIRLGSWGSWGRKLASWWPEWWGEGKAEPPGLGSLCSPGWGPQRPCASLAGGGRGRPRQGLHQPRASRRAPCLQVGPGTW

--------------------------------------------------------------
>14898_14898_8_CDC42-LDLRAD2_CDC42_chr1_22408287_ENST00000421089_LDLRAD2_chr1_22147943_ENST00000543870_length(transcript)=884nt_BP=436nt
AGTGCTGCCAACGCCCCGGTGGAGAAGCTGAGGTCATCATCAGATTTGAAATATTTAAAGTGGATACAAAACTATTTCAGCAATGCAGAC
AATTAAGTGTGTTGTTGTGGGCGATGGTGCTGTTGGTAAAACATGTCTCCTGATATCCTACACAACAAACAAATTTCCATCGGAATATGT
ACCGACTATCTTGACTTCTCATGGGTAAATTATATACACTTTAAACAGCTGAAAAATCAGTGGAAAGTCAGAAGGGGTGACACAGGGTTT
GCAAGAAGTGCTGGGAGGCAAAACTCCAGTAGACAAGATTCTAACGAGTGGTGGTCTCAATTTGGTGAAGTATGCCCTACATCTTGGAAT
GAGGTTTTTGACAACTATGCAGTCACAGTTATGATTGGTGGAGAACCATATACTCTTGGACTTTTTGATACTGCAGGTCCCTCTCCGGTG
CCCAGCCAGACAGGAAGTACAGATGCCCATACCTCCAGATCCCTGACTCCCTCCCCAGCTCTCGGGTCTGCAGGATCCCTCTGGATTGCA
GCTGAGAGGAGTTCCCCAGCAGGCAGGGACCCCACGAGACAAGACGCAGCTTTGGAAGGCTCCACTGAGTGAAGCCCTCATCAAAGACTC
AGGAGGCCCCTGGCGGGGATAGCACCGTTTATTAAGAAAAATCAAGACAAAGACCACAGGAGGGTCCCTTCTAGGACACAGAGGCCAGGC
GTCCCAACCCCACAGTCTGGGGGCCACTGGCAGGATGGCACTTGAGCTGGATCTTCAGGCTCCTGCAGATGGGGCAGGGTGGTCATATCC

>14898_14898_8_CDC42-LDLRAD2_CDC42_chr1_22408287_ENST00000421089_LDLRAD2_chr1_22147943_ENST00000543870_length(amino acids)=159AA_BP=100
MSPDILHNKQISIGICTDYLDFSWVNYIHFKQLKNQWKVRRGDTGFARSAGRQNSSRQDSNEWWSQFGEVCPTSWNEVFDNYAVTVMIGG

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CDC42-LDLRAD2


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDC42-LDLRAD2


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDC42-LDLRAD2


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDC42C0036341Schizophrenia4PSYGENET
HgeneCDC42C4225222TAKENOUCHI-KOSAKI SYNDROME3CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneCDC42C0001624Adrenal Gland Neoplasms1CTD_human
HgeneCDC42C0005818Blood Platelet Disorders1GENOMICS_ENGLAND
HgeneCDC42C0007097Carcinoma1CTD_human
HgeneCDC42C0019693HIV Infections1CTD_human
HgeneCDC42C0024667Animal Mammary Neoplasms1CTD_human
HgeneCDC42C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneCDC42C0027540Necrosis1CTD_human
HgeneCDC42C0205696Anaplastic carcinoma1CTD_human
HgeneCDC42C0205697Carcinoma, Spindle-Cell1CTD_human
HgeneCDC42C0205698Undifferentiated carcinoma1CTD_human
HgeneCDC42C0205699Carcinomatosis1CTD_human
HgeneCDC42C0750887Adrenal Cancer1CTD_human
HgeneCDC42C1257925Mammary Carcinoma, Animal1CTD_human
HgeneCDC42C3714756Intellectual Disability1GENOMICS_ENGLAND
HgeneCDC42C4505456HIV Coinfection1CTD_human