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Center for Computational Systems Medicine
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Fusion Gene Summary

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Fusion Gene ORF analysis

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Fusion Genomic Features

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Fusion Protein Features

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Fusion Gene Sequence

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Fusion Gene PPI analysis

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Related Drugs

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Related Diseases

Fusion gene:CDH1-USP10 (FusionGDB2 ID:HG999TG9100)

Fusion Gene Summary for CDH1-USP10

check button Fusion gene summary
Fusion gene informationFusion gene name: CDH1-USP10
Fusion gene ID: hg999tg9100
HgeneTgene
Gene symbol

CDH1

USP10

Gene ID

999

9100

Gene namecadherin 1ubiquitin specific peptidase 10
SynonymsArc-1|BCDS1|CD324|CDHE|ECAD|LCAM|UVOUBPO
Cytomap('CDH1')('USP10')

16q22.1

16q24.1

Type of geneprotein-codingprotein-coding
Descriptioncadherin-1CAM 120/80E-cadherin 1cadherin 1, E-cadherin (epithelial)cadherin 1, type 1, E-cadherin (epithelial)calcium-dependent adhesion protein, epithelialcell-CAM 120/80epididymis secretory sperm binding proteinepithelial cadherinuvomorulinubiquitin carboxyl-terminal hydrolase 10deubiquitinating enzyme 10ubiquitin specific protease 10ubiquitin thioesterase 10ubiquitin thiolesterase 10ubiquitin-specific-processing protease 10
Modification date2020032920200327
UniProtAcc..
Ensembl transtripts involved in fusion geneENST00000562836, ENST00000261769, 
ENST00000422392, 
Fusion gene scores* DoF score21 X 16 X 8=268817 X 15 X 9=2295
# samples 2919
** MAII scorelog2(29/2688*10)=-3.21240833276383
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(19/2295*10)=-3.59442282997022
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context

PubMed: CDH1 [Title/Abstract] AND USP10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpointCDH1(68835796)-USP10(84806147), # samples:1
Anticipated loss of major functional domain due to fusion event.CDH1-USP10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
CDH1-USP10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneCDH1

GO:0042307

positive regulation of protein import into nucleus

16338932

HgeneCDH1

GO:0045893

positive regulation of transcription, DNA-templated

16338932

HgeneCDH1

GO:0071285

cellular response to lithium ion

12937339

HgeneCDH1

GO:0071681

cellular response to indole-3-methanol

10868478

HgeneCDH1

GO:0072659

protein localization to plasma membrane

17620337

HgeneCDH1

GO:0098609

cell-cell adhesion

16338932|18593713

TgeneUSP10

GO:0010506

regulation of autophagy

21962518

TgeneUSP10

GO:0016579

protein deubiquitination

20096447


check buttonFusion gene breakpoints across CDH1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure
check buttonFusion gene breakpoints across USP10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check button Fusion gene information
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4Non-CancerTCGA-IP-7968-11ACDH1chr16

68835796

+USP10chr16

84806147

+


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Fusion Gene ORF analysis for CDH1-USP10

check button Open reading frame (ORF) analsis of fusion genes based on Ensembl gene isoform structure.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
ORFHenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrand
3UTR-3CDSENST00000562836ENST00000219473CDH1chr16

68835796

+USP10chr16

84806147

+
3UTR-3CDSENST00000562836ENST00000570191CDH1chr16

68835796

+USP10chr16

84806147

+
3UTR-intronENST00000562836ENST00000562743CDH1chr16

68835796

+USP10chr16

84806147

+
5CDS-intronENST00000261769ENST00000562743CDH1chr16

68835796

+USP10chr16

84806147

+
5CDS-intronENST00000422392ENST00000562743CDH1chr16

68835796

+USP10chr16

84806147

+
In-frameENST00000261769ENST00000219473CDH1chr16

68835796

+USP10chr16

84806147

+
In-frameENST00000261769ENST00000570191CDH1chr16

68835796

+USP10chr16

84806147

+
In-frameENST00000422392ENST00000219473CDH1chr16

68835796

+USP10chr16

84806147

+
In-frameENST00000422392ENST00000570191CDH1chr16

68835796

+USP10chr16

84806147

+

check buttonORFfinder result based on the fusion transcript sequence of in-frame fusion genes.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000261769CDH1chr1668835796+ENST00000219473USP10chr1684806147+147657841976311
ENST00000261769CDH1chr1668835796+ENST00000570191USP10chr1684806147+108957841976311
ENST00000422392CDH1chr1668835796+ENST00000219473USP10chr1684806147+134945164849261
ENST00000422392CDH1chr1668835796+ENST00000570191USP10chr1684806147+96245164849261

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261769ENST00000219473CDH1chr1668835796+USP10chr1684806147+0.0041087670.9958912
ENST00000261769ENST00000570191CDH1chr1668835796+USP10chr1684806147+0.0086627490.9913373
ENST00000422392ENST00000219473CDH1chr1668835796+USP10chr1684806147+0.0039267910.99607325
ENST00000422392ENST00000570191CDH1chr1668835796+USP10chr1684806147+0.0093733810.9906266

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Fusion Genomic Features for CDH1-USP10


check buttonFusionAI prediction of the potential fusion gene breakpoint based on the pre-mature RNA sequence context (+/- 5kb of individual partner genes, total 20kb length sequence). FusionAI is a fusion gene breakpoint classifier based on convolutional neural network by comparing the fusion positive and negative sequence context of ~ 20K fusion gene data. From here, we can have the relative potentency of the 20K genomic sequence how individual sequnce will be likely used as the gene fusion breakpoints.
HgeneHchrHbpHstrandTgeneTchrTbpTstrand1-pp (fusion gene breakpoint)
CDH1chr1668835796+USP10chr1684806146+0.169283050.83071697
CDH1chr1668835796+USP10chr1684806146+0.169283050.83071697

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions. We integrated a total of 44 different types of human genomic feature loci information across five big categories including virus integration sites, repeats, structural variants, chromatin states, and gene expression regulation. More details are in help page.
genomic feature

check buttonDistribution of 44 human genomic features loci across 20kb length fusion breakpoint regions that are ovelapped with the top 1% feature importance score regions. More details are in help page.
genomic feature of top 1%

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Fusion Protein Features for CDH1-USP10


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:68835796/chr16:84806147)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
..
FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.FUNCTION: Transcriptional activator which is required for calcium-dependent dendritic growth and branching in cortical neurons. Recruits CREB-binding protein (CREBBP) to nuclear bodies. Component of the CREST-BRG1 complex, a multiprotein complex that regulates promoter activation by orchestrating a calcium-dependent release of a repressor complex and a recruitment of an activator complex. In resting neurons, transcription of the c-FOS promoter is inhibited by BRG1-dependent recruitment of a phospho-RB1-HDAC1 repressor complex. Upon calcium influx, RB1 is dephosphorylated by calcineurin, which leads to release of the repressor complex. At the same time, there is increased recruitment of CREBBP to the promoter by a CREST-dependent mechanism, which leads to transcriptional activation. The CREST-BRG1 complex also binds to the NR2B promoter, and activity-dependent induction of NR2B expression involves a release of HDAC1 and recruitment of CREBBP (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page


* Minus value of BPloci means that the break pointn is located before the CDS.
- In-frame and retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

- In-frame and not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneCDH1chr16:68835796chr16:84806147ENST00000261769+316838_851129883.0Compositional biasNote=Ser-rich
HgeneCDH1chr16:68835796chr16:84806147ENST00000261769+316155_262129883.0DomainCadherin 1
HgeneCDH1chr16:68835796chr16:84806147ENST00000261769+316263_375129883.0DomainCadherin 2
HgeneCDH1chr16:68835796chr16:84806147ENST00000261769+316376_486129883.0DomainCadherin 3
HgeneCDH1chr16:68835796chr16:84806147ENST00000261769+316487_593129883.0DomainCadherin 4
HgeneCDH1chr16:68835796chr16:84806147ENST00000261769+316594_697129883.0DomainCadherin 5
HgeneCDH1chr16:68835796chr16:84806147ENST00000261769+316758_769129883.0RegionNote=Required for binding CTNND1 and PSEN1
HgeneCDH1chr16:68835796chr16:84806147ENST00000261769+316811_882129883.0RegionNote=Required for binding alpha%2C beta and gamma catenins
HgeneCDH1chr16:68835796chr16:84806147ENST00000261769+316155_709129883.0Topological domainExtracellular
HgeneCDH1chr16:68835796chr16:84806147ENST00000261769+316731_882129883.0Topological domainCytoplasmic
HgeneCDH1chr16:68835796chr16:84806147ENST00000261769+316710_730129883.0TransmembraneHelical
TgeneUSP10chr16:68835796chr16:84806147ENST000002194731014415_795666799.0DomainNote=USP
TgeneUSP10chr16:68835796chr16:84806147ENST000005701911115415_795670803.0DomainNote=USP


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Fusion Gene Sequence for CDH1-USP10


check button For in-frame fusion transcripts, we provide the fusion transcript sequences and fusion amino acid sequences. To have fusion amino acid sequence, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>15045_15045_1_CDH1-USP10_CDH1_chr16_68835796_ENST00000261769_USP10_chr16_84806147_ENST00000219473_length(transcript)=1476nt_BP=578nt
AGCCAATCAGCGGTACGGGGGGCGGTGCCTCCGGGGCTCACCTGGCTGCAGCCACGCACCCCCTCTCAGTGGCGTCGGAACTGCAAAGCA
CCTGTGAGCTTGCGGAAGTCAGTTCAGACTCCAGCCCGCTCCAGCCCGGCCCGACCCGACCGCACCCGGCGCCTGCCCTCGCTCGGCGTC
CCCGGCCAGCCATGGGCCCTTGGAGCCGCAGCCTCTCGGCGCTGCTGCTGCTGCTGCAGGTCTCCTCTTGGCTCTGCCAGGAGCCGGAGC
CCTGCCACCCTGGCTTTGACGCCGAGAGCTACACGTTCACGGTGCCCCGGCGCCACCTGGAGAGAGGCCGCGTCCTGGGCAGAGTGAATT
TTGAAGATTGCACCGGTCGACAAAGGACAGCCTATTTTTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTACAGTCAAAA
GGCCTCTACGGTTTCATAACCCACAGATCCATTTCTTGGTCTACGCCTGGGACTCCACCTACAGAAAGTTTTCCACCAAAGTCACGCTGA
ATACAGTGGGGCACCACCACCGCCCCCCGCCCCATCAGGTTGAGATAAGTCGAAGAGTGACTCTGGAAAAACTCCCTCCTGTCCTCGTGC
TGCACCTGAAACGATTCGTTTATGAGAAGACTGGTGGGTGCCAGAAGCTTATCAAAAATATTGAATATCCTGTGGACTTGGAAATTAGTA
AAGAACTGCTTTCTCCAGGGGTTAAAAATAAGAATTTTAAATGCCACCGAACCTATCGGCTCTTTGCAGTGGTCTACCATCACGGCAACA
GTGCGACGGGCGGCCATTACACTACAGACGTCTTCCAGATCGGTCTGAATGGCTGGCTGCGCATCGATGACCAGACAGTCAAGGTGATCA
ACCAGTACCAGGTGGTGAAACCAACTGCTGAACGCACAGCCTACCTCCTGTATTACCGCCGAGTGGACCTGCTGTAAACCCTGTGTGCGC
TGTGTGTGCGCCCAGTGCCCGCTTCGTAGGACACCACCTCACACTCACTTCCCGCCTCTCTTTAGTGGCTCTTTAGAGAGAAACTCTTTC
TCCCTTTGCAAAAATGGGCTAGAATGAAAAGGAGATGCCTTGGGGTTCGTGCACAACACAGCTTCTGTTGACTCTAACTTCCAAATCAAA
ATCATTTGGTTGAAACAGACTGTTGCTTGATTTTAGAAAATACACAAAAACCCATATTTCTGAAATAATGCTGATTCCTGAGATAAGAAA
GTGGATTTGATCCCCAGTCTCATTGCTTAGTAGAATAAATCCTGCACCAGCAACAACACTTGTAAATTTGTGAAAATGAATTTTATCTTT
CCTTAAAAAAGAAATTTTTTAATCCATCACACTTTTCTTCCCTACCCTTTAGTTTTTGATAAATGATAAAAATGAGCCAGTTATCAAAGA

>15045_15045_1_CDH1-USP10_CDH1_chr16_68835796_ENST00000261769_USP10_chr16_84806147_ENST00000219473_length(amino acids)=311AA_BP=179
MAAATHPLSVASELQSTCELAEVSSDSSPLQPGPTRPHPAPALARRPRPAMGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFT
VPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQV
EISRRVTLEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVDLEISKELLSPGVKNKNFKCHRTYRLFAVVYHHGNSATGGHYTTDVFQI

--------------------------------------------------------------
>15045_15045_2_CDH1-USP10_CDH1_chr16_68835796_ENST00000261769_USP10_chr16_84806147_ENST00000570191_length(transcript)=1089nt_BP=578nt
AGCCAATCAGCGGTACGGGGGGCGGTGCCTCCGGGGCTCACCTGGCTGCAGCCACGCACCCCCTCTCAGTGGCGTCGGAACTGCAAAGCA
CCTGTGAGCTTGCGGAAGTCAGTTCAGACTCCAGCCCGCTCCAGCCCGGCCCGACCCGACCGCACCCGGCGCCTGCCCTCGCTCGGCGTC
CCCGGCCAGCCATGGGCCCTTGGAGCCGCAGCCTCTCGGCGCTGCTGCTGCTGCTGCAGGTCTCCTCTTGGCTCTGCCAGGAGCCGGAGC
CCTGCCACCCTGGCTTTGACGCCGAGAGCTACACGTTCACGGTGCCCCGGCGCCACCTGGAGAGAGGCCGCGTCCTGGGCAGAGTGAATT
TTGAAGATTGCACCGGTCGACAAAGGACAGCCTATTTTTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTACAGTCAAAA
GGCCTCTACGGTTTCATAACCCACAGATCCATTTCTTGGTCTACGCCTGGGACTCCACCTACAGAAAGTTTTCCACCAAAGTCACGCTGA
ATACAGTGGGGCACCACCACCGCCCCCCGCCCCATCAGGTTGAGATAAGTCGAAGAGTGACTCTGGAAAAACTCCCTCCTGTCCTCGTGC
TGCACCTGAAACGATTCGTTTATGAGAAGACTGGTGGGTGCCAGAAGCTTATCAAAAATATTGAATATCCTGTGGACTTGGAAATTAGTA
AAGAACTGCTTTCTCCAGGGGTTAAAAATAAGAATTTTAAATGCCACCGAACCTATCGGCTCTTTGCAGTGGTCTACCATCACGGCAACA
GTGCGACGGGCGGCCATTACACTACAGACGTCTTCCAGATCGGTCTGAATGGCTGGCTGCGCATCGATGACCAGACAGTCAAGGTGATCA
ACCAGTACCAGGTGGTGAAACCAACTGCTGAACGCACAGCCTACCTCCTGTATTACCGCCGAGTGGACCTGCTGTAAACCCTGTGTGCGC
TGTGTGTGCGCCCAGTGCCCGCTTCGTAGGACACCACCTCACACTCACTTCCCGCCTCTCTTTAGTGGCTCTTTAGAGAGAAACTCTTTC

>15045_15045_2_CDH1-USP10_CDH1_chr16_68835796_ENST00000261769_USP10_chr16_84806147_ENST00000570191_length(amino acids)=311AA_BP=179
MAAATHPLSVASELQSTCELAEVSSDSSPLQPGPTRPHPAPALARRPRPAMGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFT
VPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLRFHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQV
EISRRVTLEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVDLEISKELLSPGVKNKNFKCHRTYRLFAVVYHHGNSATGGHYTTDVFQI

--------------------------------------------------------------
>15045_15045_3_CDH1-USP10_CDH1_chr16_68835796_ENST00000422392_USP10_chr16_84806147_ENST00000219473_length(transcript)=1349nt_BP=451nt
GCTCCAGCCCGGCCCGACCCGACCGCACCCGGCGCCTGCCCTCGCTCGGCGTCCCCGGCCAGCCATGGGCCCTTGGAGCCGCAGCCTCTC
GGCGCTGCTGCTGCTGCTGCAGGTCTCCTCTTGGCTCTGCCAGGAGCCGGAGCCCTGCCACCCTGGCTTTGACGCCGAGAGCTACACGTT
CACGGTGCCCCGGCGCCACCTGGAGAGAGGCCGCGTCCTGGGCAGAGTGAATTTTGAAGATTGCACCGGTCGACAAAGGACAGCCTATTT
TTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTACAGTCAAAAGGCCTCTACGGTTTCATAACCCACAGATCCATTTCTT
GGTCTACGCCTGGGACTCCACCTACAGAAAGTTTTCCACCAAAGTCACGCTGAATACAGTGGGGCACCACCACCGCCCCCCGCCCCATCA
GGTTGAGATAAGTCGAAGAGTGACTCTGGAAAAACTCCCTCCTGTCCTCGTGCTGCACCTGAAACGATTCGTTTATGAGAAGACTGGTGG
GTGCCAGAAGCTTATCAAAAATATTGAATATCCTGTGGACTTGGAAATTAGTAAAGAACTGCTTTCTCCAGGGGTTAAAAATAAGAATTT
TAAATGCCACCGAACCTATCGGCTCTTTGCAGTGGTCTACCATCACGGCAACAGTGCGACGGGCGGCCATTACACTACAGACGTCTTCCA
GATCGGTCTGAATGGCTGGCTGCGCATCGATGACCAGACAGTCAAGGTGATCAACCAGTACCAGGTGGTGAAACCAACTGCTGAACGCAC
AGCCTACCTCCTGTATTACCGCCGAGTGGACCTGCTGTAAACCCTGTGTGCGCTGTGTGTGCGCCCAGTGCCCGCTTCGTAGGACACCAC
CTCACACTCACTTCCCGCCTCTCTTTAGTGGCTCTTTAGAGAGAAACTCTTTCTCCCTTTGCAAAAATGGGCTAGAATGAAAAGGAGATG
CCTTGGGGTTCGTGCACAACACAGCTTCTGTTGACTCTAACTTCCAAATCAAAATCATTTGGTTGAAACAGACTGTTGCTTGATTTTAGA
AAATACACAAAAACCCATATTTCTGAAATAATGCTGATTCCTGAGATAAGAAAGTGGATTTGATCCCCAGTCTCATTGCTTAGTAGAATA
AATCCTGCACCAGCAACAACACTTGTAAATTTGTGAAAATGAATTTTATCTTTCCTTAAAAAAGAAATTTTTTAATCCATCACACTTTTC

>15045_15045_3_CDH1-USP10_CDH1_chr16_68835796_ENST00000422392_USP10_chr16_84806147_ENST00000219473_length(amino acids)=261AA_BP=129
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLR
FHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQVEISRRVTLEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVDLEISKELL

--------------------------------------------------------------
>15045_15045_4_CDH1-USP10_CDH1_chr16_68835796_ENST00000422392_USP10_chr16_84806147_ENST00000570191_length(transcript)=962nt_BP=451nt
GCTCCAGCCCGGCCCGACCCGACCGCACCCGGCGCCTGCCCTCGCTCGGCGTCCCCGGCCAGCCATGGGCCCTTGGAGCCGCAGCCTCTC
GGCGCTGCTGCTGCTGCTGCAGGTCTCCTCTTGGCTCTGCCAGGAGCCGGAGCCCTGCCACCCTGGCTTTGACGCCGAGAGCTACACGTT
CACGGTGCCCCGGCGCCACCTGGAGAGAGGCCGCGTCCTGGGCAGAGTGAATTTTGAAGATTGCACCGGTCGACAAAGGACAGCCTATTT
TTCCCTCGACACCCGATTCAAAGTGGGCACAGATGGTGTGATTACAGTCAAAAGGCCTCTACGGTTTCATAACCCACAGATCCATTTCTT
GGTCTACGCCTGGGACTCCACCTACAGAAAGTTTTCCACCAAAGTCACGCTGAATACAGTGGGGCACCACCACCGCCCCCCGCCCCATCA
GGTTGAGATAAGTCGAAGAGTGACTCTGGAAAAACTCCCTCCTGTCCTCGTGCTGCACCTGAAACGATTCGTTTATGAGAAGACTGGTGG
GTGCCAGAAGCTTATCAAAAATATTGAATATCCTGTGGACTTGGAAATTAGTAAAGAACTGCTTTCTCCAGGGGTTAAAAATAAGAATTT
TAAATGCCACCGAACCTATCGGCTCTTTGCAGTGGTCTACCATCACGGCAACAGTGCGACGGGCGGCCATTACACTACAGACGTCTTCCA
GATCGGTCTGAATGGCTGGCTGCGCATCGATGACCAGACAGTCAAGGTGATCAACCAGTACCAGGTGGTGAAACCAACTGCTGAACGCAC
AGCCTACCTCCTGTATTACCGCCGAGTGGACCTGCTGTAAACCCTGTGTGCGCTGTGTGTGCGCCCAGTGCCCGCTTCGTAGGACACCAC

>15045_15045_4_CDH1-USP10_CDH1_chr16_68835796_ENST00000422392_USP10_chr16_84806147_ENST00000570191_length(amino acids)=261AA_BP=129
MGPWSRSLSALLLLLQVSSWLCQEPEPCHPGFDAESYTFTVPRRHLERGRVLGRVNFEDCTGRQRTAYFSLDTRFKVGTDGVITVKRPLR
FHNPQIHFLVYAWDSTYRKFSTKVTLNTVGHHHRPPPHQVEISRRVTLEKLPPVLVLHLKRFVYEKTGGCQKLIKNIEYPVDLEISKELL

--------------------------------------------------------------

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Fusion Gene PPI Analysis for CDH1-USP10


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type (BIOGRID-3.4.160)
HgeneHgene's interactorsTgeneTgene's interactors


check button - Retained PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost PPIs in in-frame fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
TgeneUSP10chr16:68835796chr16:84806147ENST0000021947310142_100666.0799.0p53/TP53
TgeneUSP10chr16:68835796chr16:84806147ENST0000057019111152_100670.0803.0p53/TP53


check button - Retained PPIs, but lost function due to frame-shift fusion.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs for CDH1-USP10


check button Drugs targeting genes involved in this fusion gene.
(DrugBank Version 5.1.8 2021-05-08)
PartnerGeneUniProtAccDrugBank IDDrug nameDrug activityDrug typeDrug status

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Related Diseases for CDH1-USP10


check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneCDH1C1708349Hereditary Diffuse Gastric Cancer15CLINGEN;CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
HgeneCDH1C0346153Breast Cancer, Familial12CLINGEN
HgeneCDH1C0009405Hereditary Nonpolyposis Colorectal Neoplasms6CLINGEN
HgeneCDH1C0024623Malignant neoplasm of stomach6CGI;CTD_human;UNIPROT
HgeneCDH1C0038356Stomach Neoplasms6CGI;CTD_human
HgeneCDH1C1112155Hereditary non-polyposis colorectal cancer syndrome6CLINGEN
HgeneCDH1C1333990Hereditary Nonpolyposis Colorectal Cancer6CLINGEN
HgeneCDH1C1333991Hereditary Non-Polyposis Colon Cancer Type 26CLINGEN
HgeneCDH1C2936783Colorectal cancer, hereditary nonpolyposis, type 16CLINGEN
HgeneCDH1C0006142Malignant neoplasm of breast4CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneCDH1C0033578Prostatic Neoplasms4CTD_human
HgeneCDH1C0376358Malignant neoplasm of prostate4CTD_human;GENOMICS_ENGLAND
HgeneCDH1C0678222Breast Carcinoma4CTD_human
HgeneCDH1C1257931Mammary Neoplasms, Human4CTD_human
HgeneCDH1C1458155Mammary Neoplasms4CTD_human
HgeneCDH1C4704874Mammary Carcinoma, Human4CTD_human
HgeneCDH1C0007097Carcinoma3CTD_human
HgeneCDH1C0205696Anaplastic carcinoma3CTD_human
HgeneCDH1C0205697Carcinoma, Spindle-Cell3CTD_human
HgeneCDH1C0205698Undifferentiated carcinoma3CTD_human
HgeneCDH1C0205699Carcinomatosis3CTD_human
HgeneCDH1C0005684Malignant neoplasm of urinary bladder2CTD_human
HgeneCDH1C0005695Bladder Neoplasm2CTD_human
HgeneCDH1C0009402Colorectal Carcinoma2CTD_human
HgeneCDH1C0009404Colorectal Neoplasms2CTD_human
HgeneCDH1C0019207Hepatoma, Morris2CTD_human
HgeneCDH1C0019208Hepatoma, Novikoff2CTD_human
HgeneCDH1C0021367Mammary Ductal Carcinoma2CTD_human
HgeneCDH1C0023904Liver Neoplasms, Experimental2CTD_human
HgeneCDH1C0027626Neoplasm Invasiveness2CTD_human
HgeneCDH1C0027627Neoplasm Metastasis2CTD_human
HgeneCDH1C0086404Experimental Hepatoma2CTD_human
HgeneCDH1C0206692Carcinoma, Lobular2CGI;CTD_human;UNIPROT
HgeneCDH1C1134719Invasive Ductal Breast Carcinoma2CTD_human
HgeneCDH1C2931456Prostate cancer, familial2CTD_human
HgeneCDH1C4551988BLEPHAROCHEILODONTIC SYNDROME 12GENOMICS_ENGLAND;UNIPROT
HgeneCDH1C4722327PROSTATE CANCER, HEREDITARY, 12CTD_human
HgeneCDH1C0007137Squamous cell carcinoma1CTD_human
HgeneCDH1C0007621Neoplastic Cell Transformation1CTD_human
HgeneCDH1C0009324Ulcerative Colitis1CTD_human
HgeneCDH1C0010606Adenoid Cystic Carcinoma1CTD_human
HgeneCDH1C0014170Endometrial Neoplasms1CTD_human
HgeneCDH1C0014476Eperythrozoonosis1CTD_human
HgeneCDH1C0024667Animal Mammary Neoplasms1CTD_human
HgeneCDH1C0024668Mammary Neoplasms, Experimental1CTD_human
HgeneCDH1C0025500Mesothelioma1CTD_human
HgeneCDH1C0026936Mycoplasma Infections1CTD_human
HgeneCDH1C0027645Neoplasm Seeding1CTD_human
HgeneCDH1C0027659Neoplasms, Experimental1CTD_human
HgeneCDH1C0027746Nerve Degeneration1CTD_human
HgeneCDH1C0030297Pancreatic Neoplasm1CTD_human
HgeneCDH1C0032927Precancerous Conditions1CTD_human
HgeneCDH1C0036095Salivary Gland Neoplasms1CTD_human
HgeneCDH1C0079487Helicobacter Infections1CTD_human
HgeneCDH1C0158646Cleft palate with cleft lip1ORPHANET
HgeneCDH1C0220636Malignant neoplasm of salivary gland1CTD_human
HgeneCDH1C0235874Disease Exacerbation1CTD_human
HgeneCDH1C0282313Condition, Preneoplastic1CTD_human
HgeneCDH1C0282612Prostatic Intraepithelial Neoplasias1CTD_human
HgeneCDH1C0346647Malignant neoplasm of pancreas1CTD_human
HgeneCDH1C0476089Endometrial Carcinoma1CTD_human;GENOMICS_ENGLAND
HgeneCDH1C0919267ovarian neoplasm1CTD_human
HgeneCDH1C1140680Malignant neoplasm of ovary1CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneCDH1C1176475Ductal Carcinoma1CTD_human
HgeneCDH1C1257925Mammary Carcinoma, Animal1CTD_human
HgeneCDH1C1861536Blepharo-cheilo-dontic syndrome1ORPHANET