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Center for Computational Systems Medicine
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Fusion Gene and Fusion Protein Summary

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Fusion Amino Acid Sequences (multiple BPs and multiple gene isoforms)

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Fusion Protein Breakpoint Sequences - (for the Screening of the FusionNeoAntigens)

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Potential FusionNeoAntigens in HLA I - (netMHCpan v4.1 + deepHLApan v1.1)

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Potential FusionNeoAntigens in HLA II - (netMHCIIpan v4.1)

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Fusion Breakpoint 14 AA Peptide Structure - (RoseTTAFold)

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D - (Glide)

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Vaccine Design for the FusionNeoAntigens (RNA/protein sequences)

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Potential target of CAR-T therapy development

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Information on the samples that have these potential fusion neoantigens

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Fusion Protein Targeting Drugs - (Manual Curation)

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Fusion Protein Related diseases - (Manual Curation)

Fusion Protein:MORF4L1-PSMA4

Fusion Gene and Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MORF4L1-PSMA4
FusionPDB ID: 54605
FusionGDB2.0 ID: 54605
HgeneTgene
Gene symbol

MORF4L1

PSMA4

Gene ID

10933

5685

Gene namemortality factor 4 like 1proteasome 20S subunit alpha 4
SynonymsEaf3|FWP006|HsT17725|MEAF3|MORFRG15|MRG15|S863-6HC9|HsT17706|PSC9
Cytomap

15q25.1

15q25.1

Type of geneprotein-codingprotein-coding
Descriptionmortality factor 4-like protein 1Esa1p-associated factor 3 homologMORF-related gene 15 proteinMORF-related gene on chromosome 15protein MSL3-1transcription factor-like protein MRG15proteasome subunit alpha type-4macropain subunit C9multicatalytic endopeptidase complex subunit C9proteasome (prosome, macropain) subunit, alpha type, 4proteasome component C9proteasome subunit HC9proteasome subunit Lproteasome subunit alpha 4prot
Modification date2020031320200327
UniProtAcc

Q9UBU8

Main function of 5'-partner protein: FUNCTION: Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. The NuA4 complex ATPase and helicase activities seem to be, at least in part, contributed by the association of RUVBL1 and RUVBL2 with EP400. NuA4 may also play a direct role in DNA repair when directly recruited to sites of DNA damage. Also component of the mSin3A complex which acts to repress transcription by deacetylation of nucleosomal histones. Required for homologous recombination repair (HRR) and resistance to mitomycin C (MMC). Involved in the localization of PALB2, BRCA2 and RAD51, but not BRCA1, to DNA-damage foci. {ECO:0000269|PubMed:14966270, ECO:0000269|PubMed:20332121}.
.
Ensembl transtripts involved in fusion geneENST idsENST00000331268, ENST00000379535, 
ENST00000426013, ENST00000558502, 
ENST00000558746, ENST00000559345, 
ENST00000561171, 
ENST00000557929, 
ENST00000558094, ENST00000558281, 
ENST00000558341, ENST00000044462, 
ENST00000560217, ENST00000413382, 
ENST00000559082, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 8 X 4=28811 X 11 X 5=605
# samples 1111
** MAII scorelog2(11/288*10)=-1.38856528791765
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(11/605*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Fusion gene context

PubMed: MORF4L1 [Title/Abstract] AND PSMA4 [Title/Abstract] AND fusion [Title/Abstract]

Fusion neoantigen context

PubMed: MORF4L1 [Title/Abstract] AND PSMA4 [Title/Abstract] AND neoantigen [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MORF4L1(79186572)-PSMA4(78841131), # samples:1
Anticipated loss of major functional domain due to fusion event.MORF4L1-PSMA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MORF4L1-PSMA4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MORF4L1-PSMA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MORF4L1-PSMA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MORF4L1-PSMA4 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
MORF4L1-PSMA4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
MORF4L1-PSMA4 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
MORF4L1-PSMA4 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMORF4L1

GO:0000724

double-strand break repair via homologous recombination

20332121

HgeneMORF4L1

GO:0016575

histone deacetylation

14966270

HgeneMORF4L1

GO:0043967

histone H4 acetylation

14966270

HgeneMORF4L1

GO:0043968

histone H2A acetylation

14966270



check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:79186572/chr15:78841131)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonRetention analysis results of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features, are available here.

check buttonFusion gene breakpoints across MORF4L1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PSMA4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Amino Acid Sequences


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000379535MORF4L1chr1579186572+ENST00000559082PSMA4chr1578841131+183814414111595394
ENST00000379535MORF4L1chr1579186572+ENST00000413382PSMA4chr1578841131+185614414111595394
ENST00000426013MORF4L1chr1579186572+ENST00000559082PSMA4chr1578841131+144110442421198318
ENST00000426013MORF4L1chr1579186572+ENST00000413382PSMA4chr1578841131+145910442421198318
ENST00000331268MORF4L1chr1579186572+ENST00000559082PSMA4chr1578841131+152011232041277357
ENST00000331268MORF4L1chr1579186572+ENST00000413382PSMA4chr1578841131+153811232041277357
ENST00000558746MORF4L1chr1579186572+ENST00000559082PSMA4chr1578841131+118278564939291
ENST00000558746MORF4L1chr1579186572+ENST00000413382PSMA4chr1578841131+120078564939291
ENST00000559345MORF4L1chr1579186572+ENST00000559082PSMA4chr1578841131+13739762251130301
ENST00000559345MORF4L1chr1579186572+ENST00000413382PSMA4chr1578841131+13919762251130301
ENST00000558502MORF4L1chr1579186572+ENST00000559082PSMA4chr1578841131+107267580829249
ENST00000558502MORF4L1chr1579186572+ENST00000413382PSMA4chr1578841131+109067580829249

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000379535ENST00000559082MORF4L1chr1579186572+PSMA4chr1578841131+0.0023404820.99765956
ENST00000379535ENST00000413382MORF4L1chr1579186572+PSMA4chr1578841131+0.0024033920.99759656
ENST00000426013ENST00000559082MORF4L1chr1579186572+PSMA4chr1578841131+0.0002951690.9997048
ENST00000426013ENST00000413382MORF4L1chr1579186572+PSMA4chr1578841131+0.0002995960.9997004
ENST00000331268ENST00000559082MORF4L1chr1579186572+PSMA4chr1578841131+0.0006356080.99936444
ENST00000331268ENST00000413382MORF4L1chr1579186572+PSMA4chr1578841131+0.0006444550.9993555
ENST00000558746ENST00000559082MORF4L1chr1579186572+PSMA4chr1578841131+0.0012125940.99878746
ENST00000558746ENST00000413382MORF4L1chr1579186572+PSMA4chr1578841131+0.001287770.9987122
ENST00000559345ENST00000559082MORF4L1chr1579186572+PSMA4chr1578841131+0.0011731230.9988269
ENST00000559345ENST00000413382MORF4L1chr1579186572+PSMA4chr1578841131+0.0012200370.99877995
ENST00000558502ENST00000559082MORF4L1chr1579186572+PSMA4chr1578841131+0.0016141590.9983859
ENST00000558502ENST00000413382MORF4L1chr1579186572+PSMA4chr1578841131+0.0017439210.998256

check button Predicted full-length fusion amino acid sequences. For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among all the predicted ones.

Get the fusion protein sequences from here.

Fusion protein sequence information is available in the fasta format.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

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Fusion Protein Breakpoint Sequences for MORF4L1-PSMA4

check button +/-13 AA sequence from the breakpoints of the fusion protein sequences.
HgeneHchrHbpTgeneTchrTbpLength(fusion protein)BP in fusion proteinPeptide
MORF4L1chr1579186572PSMA4chr15788411311044262PDAPMSQVYGAPHLLRLFVEIATLTR
MORF4L1chr1579186572PSMA4chr15788411311123301PDAPMSQVYGAPHLLRLFVEIATLTR
MORF4L1chr1579186572PSMA4chr15788411311441338PDAPMSQVYGAPHLLRLFVEIATLTR
MORF4L1chr1579186572PSMA4chr1578841131675193PDAPMSQVYGAPHLLRLFVEIATLTR
MORF4L1chr1579186572PSMA4chr1578841131785235PDAPMSQVYGAPHLLRLFVEIATLTR
MORF4L1chr1579186572PSMA4chr1578841131976245PDAPMSQVYGAPHLLRLFVEIATLTR

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Potential FusionNeoAntigen Information of MORF4L1-PSMA4 in HLA I

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.
MORF4L1-PSMA4_79186572_78841131.msa

check button Potential FusionNeoAntigen Information
* We used NetMHCpan v4.1 (%rank<0.5) and deepHLApan v1.1 (immunogenic score>0.5)
Fusion geneHchrHbpTgeneTchrTbpHLA IFusionNeoAntigen peptideBinding scoreImmunogenic scoreNeoantigen start (at BP 13)Neoantigen end (at BP 13)
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:15VYGAPHLL0.99930.5345715
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:25VYGAPHLL0.99920.5167715
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:23VYGAPHLL0.99920.562715
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:20VYGAPHLL0.99920.5117715
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:31VYGAPHLL0.9990.5611715
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:10VYGAPHLL0.99820.6328715
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:14VYGAPHLL0.99240.681715
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B48:01SQVYGAPHL0.98850.5326514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A02:04HLLRLFVEI0.98720.53531221
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A33:01VYGAPHLLR0.98360.5477716
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A33:05VYGAPHLLR0.98360.5477716
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:16QVYGAPHLL0.98240.9753615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A02:38QVYGAPHLL0.97460.8233615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:17QVYGAPHLL0.97280.9838615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B39:01SQVYGAPHL0.96890.8553514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A31:02VYGAPHLLR0.96710.9069716
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A02:22QVYGAPHLL0.9580.617615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A02:21QVYGAPHLL0.95780.704615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B39:13SQVYGAPHL0.94560.8715514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A02:29QVYGAPHLL0.93010.5866615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A02:11QVYGAPHLL0.92450.596615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A02:67QVYGAPHLL0.92330.5862615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A02:24QVYGAPHLL0.92330.5862615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A02:30QVYGAPHLL0.92330.5862615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A32:13QVYGAPHLL0.92190.9735615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A02:17QVYGAPHLL0.91860.5607615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A02:04QVYGAPHLL0.91750.6906615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A31:06VYGAPHLLR0.91680.7523716
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A02:20QVYGAPHLL0.91640.6003615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B38:02SQVYGAPHL0.910.9529514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A02:35QVYGAPHLL0.90870.6077615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B38:01SQVYGAPHL0.89960.9628514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:14QVYGAPHLL0.87990.6684615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B13:02SQVYGAPHL0.86630.7638514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B08:09APHLLRLFV0.86370.84251019
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B14:01YGAPHLLRL0.80770.8913817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B14:02YGAPHLLRL0.80770.8913817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B07:10QVYGAPHLL0.78060.5899615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:10SQVYGAPHL0.77360.6092514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B13:01SQVYGAPHL0.76120.9681514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B52:01YGAPHLLRL0.74990.9156817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:03SQVYGAPHL0.71670.8142514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A02:19QVYGAPHLL0.70620.6172615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A30:08QVYGAPHLL0.69460.8576615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B47:01SQVYGAPHL0.65350.6566514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B81:01QVYGAPHLL0.64710.8298615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B52:01QVYGAPHLL0.61560.9922615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B48:01QVYGAPHLL0.60180.9373615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B08:01YGAPHLLRL0.59910.7786817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:37SQVYGAPHL0.51480.6718514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B13:02QVYGAPHLL0.46030.9121615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B13:01QVYGAPHLL0.33040.9946615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B52:01SQVYGAPHL0.03950.9797514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:25VYGAPHLLRL0.99790.5375717
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A68:08QVYGAPHLLR0.99760.5254616
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A34:02QVYGAPHLLR0.99750.5127616
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:23VYGAPHLLRL0.99730.5281717
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:20VYGAPHLLRL0.99730.5318717
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A74:09QVYGAPHLLR0.99720.7823616
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A74:03QVYGAPHLLR0.99720.7823616
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A74:11QVYGAPHLLR0.99720.7823616
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:15VYGAPHLLRL0.9970.5526717
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A31:06QVYGAPHLLR0.99660.566616
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:31VYGAPHLLRL0.99640.538717
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A31:02QVYGAPHLLR0.99050.7865616
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:10VYGAPHLLRL0.98040.5822717
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A66:03QVYGAPHLLR0.96530.5087616
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B48:01SQVYGAPHLL0.93810.7962515
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B39:13SQVYGAPHLL0.89980.9268515
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B13:02SQVYGAPHLL0.79550.8495515
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B47:01SQVYGAPHLL0.76170.5972515
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B13:01SQVYGAPHLL0.72410.9832515
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B52:01SQVYGAPHLL0.36210.989515
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:25VYGAPHLLRLF0.99990.5194718
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:15VYGAPHLLRLF0.99980.5342718
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:20VYGAPHLLRLF0.99980.514718
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:31VYGAPHLLRLF0.99980.5161718
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:17VYGAPHLLRLF0.9990.5462718
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:10VYGAPHLLRLF0.9990.5865718
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A31:08VYGAPHLLRLF0.99750.5245718
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B57:03MSQVYGAPHLL0.99750.9934415
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:16MSQVYGAPHLL0.99550.9437415
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A31:02SQVYGAPHLLR0.99330.7423516
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:14VYGAPHLLRLF0.98670.5012718
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:02VYGAPHLL0.99920.5117715
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B42:02APHLLRLF0.99470.71691018
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C01:17GAPHLLRL0.99360.967917
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:29VYGAPHLL0.9910.9552715
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:13VYGAPHLL0.98530.9576715
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MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C04:14VYGAPHLL0.95380.9511715
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MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C06:03QVYGAPHLL0.98020.9962615
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MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C08:13QVYGAPHLL0.9720.9855615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C08:04QVYGAPHLL0.9720.9855615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B39:09SQVYGAPHL0.97120.5771514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:05YGAPHLLRL0.96820.9441817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C05:09YGAPHLLRL0.96670.9275817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C12:16YGAPHLLRL0.95620.9635817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C04:10YGAPHLLRL0.95440.7984817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B39:08SQVYGAPHL0.95260.8651514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C03:14YGAPHLLRL0.94840.9755817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C04:07YGAPHLLRL0.94580.8235817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:13YGAPHLLRL0.94370.9039817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:29YGAPHLLRL0.94120.9099817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:10YGAPHLLRL0.93450.9609817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B42:02APHLLRLFV0.93180.6861019
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C04:14YGAPHLLRL0.93060.8047817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A02:07QVYGAPHLL0.93050.6354615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A02:01QVYGAPHLL0.92330.5862615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B39:05SQVYGAPHL0.92320.8397514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:80YGAPHLLRL0.91910.9565817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:67YGAPHLLRL0.91910.9565817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:27YGAPHLLRL0.91730.9369817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B42:01APHLLRLFV0.91220.68261019
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C12:16QVYGAPHLL0.90760.9832615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:04SQVYGAPHL0.90450.9225514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:95YGAPHLLRL0.90370.6008817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:19YGAPHLLRL0.90190.7617817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C08:03YGAPHLLRL0.87850.98817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:04QVYGAPHLL0.86770.9818615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C02:06QVYGAPHLL0.85230.9834615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:29QVYGAPHLL0.8480.9717615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:46YGAPHLLRL0.83950.9053817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:13QVYGAPHLL0.8350.9657615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:19QVYGAPHLL0.83370.8694615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:05QVYGAPHLL0.82760.9829615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C02:06YGAPHLLRL0.81940.9403817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C01:17YGAPHLLRL0.81130.957817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C03:14QVYGAPHLL0.80750.9904615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C08:15YGAPHLLRL0.78710.9504817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C08:03QVYGAPHLL0.7830.9935615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:27QVYGAPHLL0.77290.978615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:95QVYGAPHLL0.73850.8495615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B51:07YGAPHLLRL0.73260.7829817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C01:30YGAPHLLRL0.69930.9534817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C01:17QVYGAPHLL0.65490.9786615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B14:03YGAPHLLRL0.58180.8634817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B51:07QVYGAPHLL0.55030.93615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:05SQVYGAPHL0.52560.8396514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C01:30QVYGAPHLL0.42720.9741615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C12:04GAPHLLRLF0.33420.99918
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C06:03GAPHLLRLF0.33180.9912918
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B48:03QVYGAPHLL0.08270.8596615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:02VYGAPHLLRL0.99730.5318717
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A31:01QVYGAPHLLR0.99720.7518616
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C15:06SQVYGAPHLL0.98380.9253515
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:04SQVYGAPHLL0.91670.9352515
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B48:03SQVYGAPHLL0.76310.5548515
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:02VYGAPHLLRLF0.99980.514718
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:03VYGAPHLL0.99920.562715
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C01:03GAPHLLRL0.99580.9572917
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C01:02GAPHLLRL0.99410.9637917
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C04:04VYGAPHLL0.97230.9704715
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C14:02VYGAPHLL0.9390.9816715
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C14:03VYGAPHLL0.9390.9816715
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C06:06VYGAPHLL0.93210.9948715
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C03:03YGAPHLLRL0.99960.9516817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C03:04YGAPHLLRL0.99960.9516817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C03:17YGAPHLLRL0.99930.9452817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C03:05YGAPHLLRL0.99920.8448817
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MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C15:05QVYGAPHLL0.99910.9654615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C15:02QVYGAPHLL0.9990.9625615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C03:67YGAPHLLRL0.9990.9326817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C15:09QVYGAPHLL0.99890.9644615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C15:05YGAPHLLRL0.99820.9002817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C15:02YGAPHLLRL0.99810.8452817
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MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C03:04QVYGAPHLL0.99790.9947615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C03:17QVYGAPHLL0.99620.9838615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C03:05QVYGAPHLL0.99610.9529615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C03:02QVYGAPHLL0.9960.9838615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C03:67QVYGAPHLL0.99590.9923615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C03:02YGAPHLLRL0.99540.941817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C04:04YGAPHLLRL0.99480.8497817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C04:04QVYGAPHLL0.99470.964615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C16:04QVYGAPHLL0.99350.9886615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C06:17YGAPHLLRL0.98860.993817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C06:02YGAPHLLRL0.98860.993817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C12:03YGAPHLLRL0.98820.9853817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C12:03QVYGAPHLL0.98740.9899615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C03:06QVYGAPHLL0.98510.9951615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A32:01QVYGAPHLL0.98490.9797615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C03:06YGAPHLLRL0.97870.9595817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B39:02SQVYGAPHL0.97750.8659514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:04YGAPHLLRL0.97390.9022817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C06:17QVYGAPHLL0.97150.9956615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C06:02QVYGAPHLL0.97150.9956615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B39:31SQVYGAPHL0.97140.8561514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C16:02QVYGAPHLL0.97140.9954615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C16:04YGAPHLLRL0.97060.9834817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C05:01YGAPHLLRL0.96670.9275817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C04:03YGAPHLLRL0.96210.8584817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A32:01HLLRLFVEI0.96210.94981221
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C18:01YGAPHLLRL0.960.8176817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A02:14QVYGAPHLL0.95960.6443615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A02:06QVYGAPHLL0.95780.704615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C16:01YGAPHLLRL0.95730.9786817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:73SQVYGAPHL0.95690.9443514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C06:06YGAPHLLRL0.95470.9864817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C16:02YGAPHLLRL0.95270.9902817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C12:02YGAPHLLRL0.95140.9716817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C04:01YGAPHLLRL0.94580.8235817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A68:02QVYGAPHLL0.94320.8262615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B35:13YGAPHLLRL0.92890.7752817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C12:02QVYGAPHLL0.92620.9838615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:17YGAPHLLRL0.92540.9625817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A02:03QVYGAPHLL0.92410.7521615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:22YGAPHLLRL0.92170.6671817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:02YGAPHLLRL0.91910.9565817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C06:06QVYGAPHLL0.91870.9951615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B35:13QVYGAPHLL0.91050.9645615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:01YGAPHLLRL0.9040.6071817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B39:11SQVYGAPHL0.90070.8184514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B38:05SQVYGAPHL0.89960.9628514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:22QVYGAPHLL0.89430.8423615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:04QVYGAPHLL0.88830.9467615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:30SQVYGAPHL0.87920.8459514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C08:01YGAPHLLRL0.87850.98817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:53SQVYGAPHL0.87310.8801514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A69:01QVYGAPHLL0.87230.7676615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A25:01QVYGAPHLL0.8590.9644615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C01:03YGAPHLLRL0.85210.9428817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C01:02YGAPHLLRL0.81860.9547817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B07:13QVYGAPHLL0.81370.8971615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C02:02QVYGAPHLL0.79220.9873615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C02:10QVYGAPHLL0.79220.9873615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C02:02YGAPHLLRL0.79040.9613817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C02:10YGAPHLLRL0.79040.9613817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C08:02YGAPHLLRL0.78710.9504817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:73QVYGAPHLL0.78390.9918615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:54SQVYGAPHL0.7830.8508514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C08:01QVYGAPHLL0.7830.9935615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B08:12YGAPHLLRL0.77080.8311817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C06:08YGAPHLLRL0.77050.9881817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B48:05QVYGAPHLL0.76750.5182615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C07:01QVYGAPHLL0.72960.8472615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C06:08QVYGAPHLL0.72640.9925615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:68SQVYGAPHL0.70740.6665514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B48:02SQVYGAPHL0.69380.8799514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:30QVYGAPHLL0.69010.9865615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C01:02QVYGAPHLL0.67860.977615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C01:03QVYGAPHLL0.67750.9607615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C17:01YGAPHLLRL0.6560.929817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:09SQVYGAPHL0.63670.8581514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B51:06QVYGAPHLL0.62650.5309615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B08:18YGAPHLLRL0.59910.7786817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:20SQVYGAPHL0.51490.8967514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B35:28SQVYGAPHL0.49860.9022514
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C17:01QVYGAPHLL0.45420.9866615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B07:13YGAPHLLRL0.43930.8453817
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C02:02GAPHLLRLF0.27120.959918
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-C02:10GAPHLLRLF0.27120.959918
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B40:21QVYGAPHLL0.23420.9285615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B67:01APHLLRLFV0.15120.72161019
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B40:12QVYGAPHLL0.08270.8596615
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A24:03VYGAPHLLRL0.99730.5281717
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-A74:01QVYGAPHLLR0.99720.7823616
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:68SQVYGAPHLL0.96280.66515
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:73SQVYGAPHLL0.94460.96515
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B39:02SQVYGAPHLL0.94450.9171515
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:54SQVYGAPHLL0.92450.8686515
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B15:30SQVYGAPHLL0.9210.8942515
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B40:49SQVYGAPHLL0.77140.5379515
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B40:21SQVYGAPHLL0.76810.6409515
MORF4L1-PSMA4chr1579186572chr15788411311123HLA-B40:12SQVYGAPHLL0.76310.5548515

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Potential FusionNeoAntigen Information of MORF4L1-PSMA4 in HLA II

check button Multiple sequence alignments of the potential FusionNeoAntigens per fusion breakpoints. If the MSA is empty, then it means that there were predicted fusion neoantigens in this fusion breakpoint, but those predicted fusion neoantigens were not across the breakpoint, which is not fusion-specific.

check button Potential FusionNeoAntigen Information
* We used NetMHCIIpan v4.1 (%rank<0.5).
Fusion geneHchrHbpTgeneTchrTbpHLA IIFusionNeoAntigen peptideNeoantigen start (at BP 13)Neoantigen end (at BP 13)

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Fusion breakpoint peptide structures of MORF4L1-PSMA4

check button3D structures of the fusion breakpoint peptide of 14AA sequence that have potential fusion neoantigens
* The minimum length of the amino acid sequence in RoseTTAFold is 14AA. Here, we predicted the 14AA fusion protein breakpoint sequence not the fusion neoantigen peptide, which is shorter than 14 AA.
File nameBPseqHgeneTgeneHchrHbpTchrTbpAAlen
7642QVYGAPHLLRLFVEMORF4L1PSMA4chr1579186572chr15788411311123

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Filtering FusionNeoAntigens Through Checking the Interaction with HLAs in 3D of MORF4L1-PSMA4

check buttonVirtual screening between 25 HLAs (from PDB) and FusionNeoAntigens
* We used Glide to predict the interaction between HLAs and neoantigens.
HLA allelePDB IDFile nameBPseqDocking scoreGlide score
HLA-B14:023BVN7642QVYGAPHLLRLFVE-7.15543-7.26883
HLA-B14:023BVN7642QVYGAPHLLRLFVE-4.77435-5.80965
HLA-B52:013W397642QVYGAPHLLRLFVE-6.80875-6.92215
HLA-B52:013W397642QVYGAPHLLRLFVE-4.20386-5.23916
HLA-A11:014UQ27642QVYGAPHLLRLFVE-7.5194-8.5547
HLA-A11:014UQ27642QVYGAPHLLRLFVE-6.9601-7.0735
HLA-A24:025HGA7642QVYGAPHLLRLFVE-7.52403-7.63743
HLA-A24:025HGA7642QVYGAPHLLRLFVE-5.82433-6.85963
HLA-B27:056PYJ7642QVYGAPHLLRLFVE-3.28285-4.31815
HLA-B44:053DX87642QVYGAPHLLRLFVE-5.91172-6.94702
HLA-B44:053DX87642QVYGAPHLLRLFVE-4.24346-4.35686

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Vaccine Design for the FusionNeoAntigens of MORF4L1-PSMA4

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-Is.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptide sequenceFusionNeoAntigen RNA sequence
MORF4L1-PSMA4chr1579186572chr15788411311018APHLLRLFGATTATTTGTGGAAATTGCAACAC
MORF4L1-PSMA4chr1579186572chr15788411311019APHLLRLFVGATTATTTGTGGAAATTGCAACACTAA
MORF4L1-PSMA4chr1579186572chr15788411311221HLLRLFVEITTGTGGAAATTGCAACACTAACAAGAG
MORF4L1-PSMA4chr1579186572chr1578841131415MSQVYGAPHLLGAGCGCCACATCTCCTGAGATTATTTGTGGAAA
MORF4L1-PSMA4chr1579186572chr1578841131514SQVYGAPHLCGCCACATCTCCTGAGATTATTTGTGG
MORF4L1-PSMA4chr1579186572chr1578841131515SQVYGAPHLLCGCCACATCTCCTGAGATTATTTGTGGAAA
MORF4L1-PSMA4chr1579186572chr1578841131516SQVYGAPHLLRCGCCACATCTCCTGAGATTATTTGTGGAAATTG
MORF4L1-PSMA4chr1579186572chr1578841131615QVYGAPHLLCACATCTCCTGAGATTATTTGTGGAAA
MORF4L1-PSMA4chr1579186572chr1578841131616QVYGAPHLLRCACATCTCCTGAGATTATTTGTGGAAATTG
MORF4L1-PSMA4chr1579186572chr1578841131715VYGAPHLLATCTCCTGAGATTATTTGTGGAAA
MORF4L1-PSMA4chr1579186572chr1578841131716VYGAPHLLRATCTCCTGAGATTATTTGTGGAAATTG
MORF4L1-PSMA4chr1579186572chr1578841131717VYGAPHLLRLATCTCCTGAGATTATTTGTGGAAATTGCAA
MORF4L1-PSMA4chr1579186572chr1578841131718VYGAPHLLRLFATCTCCTGAGATTATTTGTGGAAATTGCAACAC
MORF4L1-PSMA4chr1579186572chr1578841131817YGAPHLLRLTCCTGAGATTATTTGTGGAAATTGCAA
MORF4L1-PSMA4chr1579186572chr1578841131917GAPHLLRLTGAGATTATTTGTGGAAATTGCAA
MORF4L1-PSMA4chr1579186572chr1578841131918GAPHLLRLFTGAGATTATTTGTGGAAATTGCAACAC

check button mRNA and peptide sequences of FusionNeoAntigens that have potential interaction with HLA-IIs.
Fusion geneHchrHbpTchrTbpStart in +/-13AAEnd in +/-13AAFusionNeoAntigen peptideFusionNEoAntigen RNA sequence

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Information of the samples that have these potential fusion neoantigens of MORF4L1-PSMA4

check button These samples were reported as having these fusion breakpoints. For individual breakpoints, we checked the open reading frames considering multiple gene isoforms and chose the in-frame fusion genes only. Then, we made fusion protein sequences and predicted the fusion neoantigens. These fusion-positive samples may have these potential fusion neoantigens.
Cancer typeFusion geneHchrHbpHenstTchrTbpTenstSample
OVMORF4L1-PSMA4chr1579186572ENST00000331268chr1578841131ENST00000413382TCGA-24-1562

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Potential target of CAR-T therapy development for MORF4L1-PSMA4

check button Predicted 3D structure. We used RoseTTAFold.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, to provide the retention of the transmembrane domain, we only show the protein feature retention information of those transmembrane features


* Minus value of BPloci means that the break point is located before the CDS.
- In-frame and retained 'Transmembrane'.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note

check button Subcellular localization prediction of the transmembrane domain retained fusion proteins
* We used DeepLoc 1.0. The order of the X-axis of the barplot is as follows: Entry_ID, Localization, Type, Nucleus, Cytoplasm, Extracellular, Mitochondrion, Cell_membrane, Endoplasmic_reticulum, Plastid, Golgi.apparatus, Lysosome.Vacuole, Peroxisome. Y-axis is the output score of DeepLoc. Clicking the image will open a new tab with a large image.
HgeneHchrHbpHenstTgeneTchrTbpTenstDeepLoc result

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Related Drugs to MORF4L1-PSMA4

check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MORF4L1-PSMA4

check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource