About FusionPDB

Tumorigenic functions due to the formation of fusion genes were targeted for cancer therapeutics (i.e., kinase inhibitors). However, there are still many fusion proteins awaiting being targeted for therapeutics with multiple different mechanisms. Due to the lack of the whole fusion protein sequences, whole 3D structures of the fusion proteins, it was hard to develop novel therapeutic approaches of fusion gene patients. To fill these critical gaps, we developed a new computational pipeline and a resource of human fusion proteins, named FusionPDB available at https://compbio.uth.edu/FusionPDB. FusionPDB provides ~ 42K fusion protein sequences (of 16K in-frame fusion genes, Level 1), 2300 + 1267 fusion protein 3D structures (of 2300 recurrent + 266 manually curated in-frame fusion genes, Level 2), pLDDT score distribution check around the best active sites of 1267 fusion proteins (of 266 manually curated in-frame fusion genes, Level 3), and virtual screening results of 68 chosen fusion proteins (out of 266 manually curated in-frame fusion genes, Level 4). FusionPDB is the only resource providing whole 3D structures of fusion proteins and comprehensive knowledge of human fusion proteins. It will be regularly updated until covering all human fusion proteins in the future.