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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:ZCCHC7-TEK

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: ZCCHC7-TEK
	FusionPDB ID: 100712
	FusionGDB2.0 ID: 100712
		Hgene	Tgene
	Gene symbol	ZCCHC7	TEK
	Gene ID	84186	7010
	Gene name	zinc finger CCHC-type containing 7	TEK receptor tyrosine kinase
	Synonyms	AIR1\|HSPC086	CD202B\|GLC3E\|TIE-2\|TIE2\|VMCM\|VMCM1
	Cytomap	9p13.2	9p21.2
	Type of gene	protein-coding	protein-coding
	Description	zinc finger CCHC domain-containing protein 7TRAMP-like complex RNA-binding factor ZCCHC7zinc finger, CCHC domain containing 7	angiopoietin-1 receptorTEK tyrosine kinase, endothelialendothelial tyrosine kinasetunica interna endothelial cell kinasetyrosine kinase with Ig and EGF homology domains-2tyrosine-protein kinase receptor TEKtyrosine-protein kinase receptor TIE-2
	Modification date	20200320	20200322
	UniProtAcc	Q8N3Z6	TEKT5
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000461038, ENST00000322831, ENST00000336755, ENST00000534928,	ENST00000380036, ENST00000406359, ENST00000519097,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	29 X 11 X 11=3509	5 X 5 X 2=50
	# samples	29	5
	** MAII score	log2(29/3509*10)=-3.59693514238723 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/50*10)=0
Context (manual curation of fusion genes in FusionPDB)	PubMed: ZCCHC7 [Title/Abstract] AND TEK [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	ZCCHC7(37126939)-TEK(27197313), # samples:3
Anticipated loss of major functional domain due to fusion event.	ZCCHC7-TEK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ZCCHC7-TEK seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ZCCHC7-TEK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ZCCHC7-TEK seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	TEK	GO:0001934	positive regulation of protein phosphorylation	15284220
Tgene	TEK	GO:0007169	transmembrane receptor protein tyrosine kinase signaling pathway	15284220
Tgene	TEK	GO:0010595	positive regulation of endothelial cell migration	15284220
Tgene	TEK	GO:0018108	peptidyl-tyrosine phosphorylation	11513602
Tgene	TEK	GO:0045766	positive regulation of angiogenesis	15284220
Tgene	TEK	GO:0046777	protein autophosphorylation	11513602
Tgene	TEK	GO:0048014	Tie signaling pathway	15284220\|19223473
Tgene	TEK	GO:0051897	positive regulation of protein kinase B signaling	19615361
Tgene	TEK	GO:0070374	positive regulation of ERK1 and ERK2 cascade	19615361

Fusion gene breakpoints across ZCCHC7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TEK (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-XF-A9T4-01A	ZCCHC7	chr9	37126939	-	TEK	chr9	27197313	+
ChimerDB4	BLCA	TCGA-XF-A9T4-01A	ZCCHC7	chr9	37126939	+	TEK	chr9	27197313	+
ChimerDB4	BLCA	TCGA-XF-A9T4	ZCCHC7	chr9	37126939	+	TEK	chr9	27197313	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000336755	ZCCHC7	chr9	37126939	+	ENST00000519097	TEK	chr9	27197313	+	2919	716	106	2463	785
ENST00000336755	ZCCHC7	chr9	37126939	+	ENST00000380036	TEK	chr9	27197313	+	3410	716	106	2466	786
ENST00000336755	ZCCHC7	chr9	37126939	+	ENST00000406359	TEK	chr9	27197313	+	2981	716	106	2466	786
ENST00000322831	ZCCHC7	chr9	37126939	+	ENST00000519097	TEK	chr9	27197313	+	3079	876	266	2623	785
ENST00000322831	ZCCHC7	chr9	37126939	+	ENST00000380036	TEK	chr9	27197313	+	3570	876	266	2626	786
ENST00000322831	ZCCHC7	chr9	37126939	+	ENST00000406359	TEK	chr9	27197313	+	3141	876	266	2626	786

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000336755	ENST00000519097	ZCCHC7	chr9	37126939	+	TEK	chr9	27197313	+	0.000636519	0.9993635
ENST00000336755	ENST00000380036	ZCCHC7	chr9	37126939	+	TEK	chr9	27197313	+	0.000340402	0.99965966
ENST00000336755	ENST00000406359	ZCCHC7	chr9	37126939	+	TEK	chr9	27197313	+	0.000511382	0.9994886
ENST00000322831	ENST00000519097	ZCCHC7	chr9	37126939	+	TEK	chr9	27197313	+	0.000810984	0.99918896
ENST00000322831	ENST00000380036	ZCCHC7	chr9	37126939	+	TEK	chr9	27197313	+	0.000396215	0.9996038
ENST00000322831	ENST00000406359	ZCCHC7	chr9	37126939	+	TEK	chr9	27197313	+	0.000644691	0.99935526

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>100712_100712_1_ZCCHC7-TEK_ZCCHC7_chr9_37126939_ENST00000322831_TEK_chr9_27197313_ENST00000380036_length(amino acids)=786AA_BP=203
MMFGGYETIEAYEDDLYRDESSSELSVDSEVEFQLYSQIHYAQDLDDVIREEEHEEKNSGNSESSSSKPNQKKLIVLSDSEVIQLSDGSE
VITLSDEDSIYRCKGKNVRVQAQENAHGLSSSLQSNELVDKKCKSDIEKPKSEERSGVIREVMIIEVSSSEEEESTISEGDNVESWMLLG
CEVDDKDDDILLNLVGCENSVTEGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPR
EQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQ
LKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNV
REEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCK
LGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAAR
NILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLE

--------------------------------------------------------------

>100712_100712_2_ZCCHC7-TEK_ZCCHC7_chr9_37126939_ENST00000322831_TEK_chr9_27197313_ENST00000406359_length(amino acids)=786AA_BP=203
MMFGGYETIEAYEDDLYRDESSSELSVDSEVEFQLYSQIHYAQDLDDVIREEEHEEKNSGNSESSSSKPNQKKLIVLSDSEVIQLSDGSE
VITLSDEDSIYRCKGKNVRVQAQENAHGLSSSLQSNELVDKKCKSDIEKPKSEERSGVIREVMIIEVSSSEEEESTISEGDNVESWMLLG
CEVDDKDDDILLNLVGCENSVTEGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPR
EQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQ
LKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNV
REEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCK
LGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAAR
NILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLE

--------------------------------------------------------------

>100712_100712_3_ZCCHC7-TEK_ZCCHC7_chr9_37126939_ENST00000322831_TEK_chr9_27197313_ENST00000519097_length(amino acids)=785AA_BP=203
MMFGGYETIEAYEDDLYRDESSSELSVDSEVEFQLYSQIHYAQDLDDVIREEEHEEKNSGNSESSSSKPNQKKLIVLSDSEVIQLSDGSE
VITLSDEDSIYRCKGKNVRVQAQENAHGLSSSLQSNELVDKKCKSDIEKPKSEERSGVIREVMIIEVSSSEEEESTISEGDNVESWMLLG
CEVDDKDDDILLNLVGCENSVTEGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPR
EQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQ
LKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNR
EEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKL
GHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARN
ILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEK

--------------------------------------------------------------

>100712_100712_4_ZCCHC7-TEK_ZCCHC7_chr9_37126939_ENST00000336755_TEK_chr9_27197313_ENST00000380036_length(amino acids)=786AA_BP=203
MMFGGYETIEAYEDDLYRDESSSELSVDSEVEFQLYSQIHYAQDLDDVIREEEHEEKNSGNSESSSSKPNQKKLIVLSDSEVIQLSDGSE
VITLSDEDSIYRCKGKNVRVQAQENAHGLSSSLQSNELVDKKCKSDIEKPKSEERSGVIREVMIIEVSSSEEEESTISEGDNVESWMLLG
CEVDDKDDDILLNLVGCENSVTEGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPR
EQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQ
LKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNV
REEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCK
LGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAAR
NILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLE

--------------------------------------------------------------

>100712_100712_5_ZCCHC7-TEK_ZCCHC7_chr9_37126939_ENST00000336755_TEK_chr9_27197313_ENST00000406359_length(amino acids)=786AA_BP=203
MMFGGYETIEAYEDDLYRDESSSELSVDSEVEFQLYSQIHYAQDLDDVIREEEHEEKNSGNSESSSSKPNQKKLIVLSDSEVIQLSDGSE
VITLSDEDSIYRCKGKNVRVQAQENAHGLSSSLQSNELVDKKCKSDIEKPKSEERSGVIREVMIIEVSSSEEEESTISEGDNVESWMLLG
CEVDDKDDDILLNLVGCENSVTEGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPR
EQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQ
LKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNV
REEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCK
LGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAAR
NILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLE

--------------------------------------------------------------

>100712_100712_6_ZCCHC7-TEK_ZCCHC7_chr9_37126939_ENST00000336755_TEK_chr9_27197313_ENST00000519097_length(amino acids)=785AA_BP=203
MMFGGYETIEAYEDDLYRDESSSELSVDSEVEFQLYSQIHYAQDLDDVIREEEHEEKNSGNSESSSSKPNQKKLIVLSDSEVIQLSDGSE
VITLSDEDSIYRCKGKNVRVQAQENAHGLSSSLQSNELVDKKCKSDIEKPKSEERSGVIREVMIIEVSSSEEEESTISEGDNVESWMLLG
CEVDDKDDDILLNLVGCENSVTEGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPR
EQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQ
LKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNR
EEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCKL
GHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAARN
ILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLEK

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:37126939/chr9:27197313)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
ZCCHC7 Q8N3Z6	TEK TEKT5
	485

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000380036

545_636

541.3333333333334

1125.0

Domain

Fibronectin type-III 2

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000380036

641_735

541.3333333333334

1125.0

Domain

Fibronectin type-III 3

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000380036

824_1096

541.3333333333334

1125.0

Domain

Protein kinase

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000406359

545_636

498.3333333333333

1082.0

Domain

Fibronectin type-III 2

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000406359

641_735

498.3333333333333

1082.0

Domain

Fibronectin type-III 3

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000406359

824_1096

498.3333333333333

1082.0

Domain

Protein kinase

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000519097

447_541

394.3333333333333

977.0

Domain

Fibronectin type-III 1

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000519097

545_636

394.3333333333333

977.0

Domain

Fibronectin type-III 2

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000519097

641_735

394.3333333333333

977.0

Domain

Fibronectin type-III 3

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000519097

824_1096

394.3333333333333

977.0

Domain

Protein kinase

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000380036

830_838

541.3333333333334

1125.0

Nucleotide binding

ATP

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000406359

830_838

498.3333333333333

1082.0

Nucleotide binding

ATP

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000519097

830_838

394.3333333333333

977.0

Nucleotide binding

ATP

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000380036

770_1124

541.3333333333334

1125.0

Topological domain

Cytoplasmic

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000406359

770_1124

498.3333333333333

1082.0

Topological domain

Cytoplasmic

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000519097

770_1124

394.3333333333333

977.0

Topological domain

Cytoplasmic

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000380036

749_769

541.3333333333334

1125.0

Transmembrane

Helical

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000406359

749_769

498.3333333333333

1082.0

Transmembrane

Helical

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000519097

749_769

394.3333333333333

977.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

ZCCHC7

chr9:37126939

chr9:27197313

ENST00000336755

241_258

203.33333333333334

544.0

Zinc finger

CCHC-type 1

Hgene

ZCCHC7

chr9:37126939

chr9:27197313

ENST00000336755

263_280

203.33333333333334

544.0

Zinc finger

CCHC-type 2

Hgene

ZCCHC7

chr9:37126939

chr9:27197313

ENST00000336755

304_321

203.33333333333334

544.0

Zinc finger

CCHC-type 3

Hgene

ZCCHC7

chr9:37126939

chr9:27197313

ENST00000336755

348_365

203.33333333333334

544.0

Zinc finger

CCHC-type 4

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000380036

210_252

541.3333333333334

1125.0

Domain

EGF-like 1

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000380036

254_299

541.3333333333334

1125.0

Domain

EGF-like 2

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000380036

301_341

541.3333333333334

1125.0

Domain

EGF-like 3

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000380036

350_440

541.3333333333334

1125.0

Domain

Note=Ig-like C2-type 2

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000380036

447_541

541.3333333333334

1125.0

Domain

Fibronectin type-III 1

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000380036

44_123

541.3333333333334

1125.0

Domain

Note=Ig-like C2-type 1

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000406359

210_252

498.3333333333333

1082.0

Domain

EGF-like 1

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000406359

254_299

498.3333333333333

1082.0

Domain

EGF-like 2

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000406359

301_341

498.3333333333333

1082.0

Domain

EGF-like 3

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000406359

350_440

498.3333333333333

1082.0

Domain

Note=Ig-like C2-type 2

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000406359

447_541

498.3333333333333

1082.0

Domain

Fibronectin type-III 1

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000406359

44_123

498.3333333333333

1082.0

Domain

Note=Ig-like C2-type 1

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000519097

210_252

394.3333333333333

977.0

Domain

EGF-like 1

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000519097

254_299

394.3333333333333

977.0

Domain

EGF-like 2

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000519097

301_341

394.3333333333333

977.0

Domain

EGF-like 3

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000519097

350_440

394.3333333333333

977.0

Domain

Note=Ig-like C2-type 2

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000519097

44_123

394.3333333333333

977.0

Domain

Note=Ig-like C2-type 1

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000380036

23_748

541.3333333333334

1125.0

Topological domain

Extracellular

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000406359

23_748

498.3333333333333

1082.0

Topological domain

Extracellular

Tgene

TEK

chr9:37126939

chr9:27197313

ENST00000519097

23_748

394.3333333333333

977.0

Topological domain

Extracellular

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1570_ZCCHC7_37126939_TEK_27197313_ranked_0.pdb	ZCCHC7	37126939	37126939	ENST00000406359	TEK	chr9	27197313	+	MMFGGYETIEAYEDDLYRDESSSELSVDSEVEFQLYSQIHYAQDLDDVIREEEHEEKNSGNSESSSSKPNQKKLIVLSDSEVIQLSDGSE VITLSDEDSIYRCKGKNVRVQAQENAHGLSSSLQSNELVDKKCKSDIEKPKSEERSGVIREVMIIEVSSSEEEESTISEGDNVESWMLLG CEVDDKDDDILLNLVGCENSVTEGLPPPRGLNLLPKSQTTLNLTWQPIFPSSEDDFYVEVERRSVQKSDQQNIKVPGNLTSVLLNNLHPR EQYVVRARVNTKAQGEWSEDLTAWTLSDILPPQPENIKISNITHSSAVISWTILDGYSISSITIRYKVQGKNEDQHVDVKIKNATITQYQ LKGLEPETAYQVDIFAENNIGSSNPAFSHELVTLPESQAPADLGGGKMLLIAILGSAGMTCLTVLLAFLIILQLKRANVQRRMAQAFQNV REEPAVQFNSGTLALNRKVKNNPDPTIYPVLDWNDIKFQDVIGEGNFGQVLKARIKKDGLRMDAAIKRMKEYASKDDHRDFAGELEVLCK LGHHPNIINLLGACEHRGYLYLAIEYAPHGNLLDFLRKSRVLETDPAFAIANSTASTLSSQQLLHFAADVARGMDYLSQKQFIHRDLAAR NILVGENYVAKIADFGLSRGQEVYVKKTMGRLPVRWMAIESLNYSVYTTNSDVWSYGVLLWEIVSLGGTPYCGMTCAELYEKLPQGYRLE	786

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

ZCCHC7_pLDDT.png

TEK_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

ZCCHC7

PAPD5, PAPD7, ELAVL1, LYN, SUMO1, SUMO2, PHC1, UBE2I, CARD9, RPL10A, RPL14, PDLIM7, HDLBP, SENP5, EIF2S2, HDGFRP2, ZNHIT6, FAM208A, PPAN, HIST1H1T, KIAA0020, NOL12, DGCR8, RPL28, ZKSCAN1, RNF4, CREBBP, HIST1H4A, KIF9, NEK6, GIPC2, TRIM41, LCE1E, ZNF250, NPM1, MKI67, PRKRA, NEIL1, RPL13, RPL3, RPL36, SART1, CCDC137, RPL11, ZBTB47, SRP14, RPL8, MPHOSPH6, ZNF467, ZC3H10, CPNE2, RPL7A, RPL4, RBM4B, RPLP0,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
ZCCHC7
TEK

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to ZCCHC7-TEK

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to ZCCHC7-TEK

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source