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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:CEP170-RAD51B

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: CEP170-RAD51B
	FusionPDB ID: 15803
	FusionGDB2.0 ID: 15803
		Hgene	Tgene
	Gene symbol	CEP170	RAD51B
	Gene ID	9859	5890
	Gene name	centrosomal protein 170	RAD51 paralog B
	Synonyms	FAM68A\|KAB\|KIAA0470	R51H2\|RAD51L1\|REC2
	Cytomap	1q43	14q24.1
	Type of gene	protein-coding	protein-coding
	Description	centrosomal protein of 170 kDaKARP-1-binding proteinXRCC5 binding proteincentrosomal protein 170kDa	DNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair protein
	Modification date	20200313	20200313
	UniProtAcc	Q9Y4F5	O15315
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000366542, ENST00000366543, ENST00000366544, ENST00000468254, ENST00000481987, ENST00000490813,	ENST00000469165, ENST00000390683, ENST00000471583, ENST00000487270, ENST00000487861, ENST00000488612,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	12 X 9 X 10=1080	41 X 23 X 12=11316
	# samples	13	56
	** MAII score	log2(13/1080*10)=-3.05444778402238 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(56/11316*10)=-4.33679344445129 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: CEP170 [Title/Abstract] AND RAD51B [Title/Abstract] AND fusion [Title/Abstract] Genomic and Molecular Landscape of DNA Damage Repair Deficiency across The Cancer Genome Atlas (pmid: 29617664)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	CEP170(243349080)-RAD51B(68758600), # samples:12
Anticipated loss of major functional domain due to fusion event.	CEP170-RAD51B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CEP170-RAD51B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. CEP170-RAD51B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. CEP170-RAD51B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across CEP170 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RAD51B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-BH-A203	CEP170	chr1	243349080	-	RAD51B	chr14	68758600	+
ChimerDB4	ESCA	TCGA-LN-A5U5	CEP170	chr1	243349080	-	RAD51B	chr14	68758600	+
ChimerDB4	ESCA	TCGA-LN-A8HZ	CEP170	chr1	243349080	-	RAD51B	chr14	68758600	+
ChimerDB4	ESCA	TCGA-VR-A8EP	CEP170	chr1	243349080	-	RAD51B	chr14	68758600	+
ChimerDB4	ESCA	TCGA-Z6-A8JD	CEP170	chr1	243349080	-	RAD51B	chr14	68758600	+
ChimerDB4	LGG	TCGA-DB-5273	CEP170	chr1	243349080	-	RAD51B	chr14	68758600	+
ChimerDB4	LGG	TCGA-DU-6399	CEP170	chr1	243349080	-	RAD51B	chr14	68758600	+
ChimerDB4	LGG	TCGA-DU-A7TI	CEP170	chr1	243349080	-	RAD51B	chr14	68758600	+
ChimerDB4	LGG	TCGA-FG-A711	CEP170	chr1	243349080	-	RAD51B	chr14	68758600	+
ChimerDB4	LGG	TCGA-HT-7485	CEP170	chr1	243349080	-	RAD51B	chr14	68758600	+
ChimerDB4	LGG	TCGA-S9-A6U6	CEP170	chr1	243349080	-	RAD51B	chr14	68758600	+
ChimerDB4	LUSC	TCGA-85-6798	CEP170	chr1	243349080	-	RAD51B	chr14	68758600	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000366542	CEP170	chr1	243349080	-	ENST00000487861	RAD51B	chr14	68758600	+	2458	1618	52	2139	695
ENST00000366542	CEP170	chr1	243349080	-	ENST00000471583	RAD51B	chr14	68758600	+	2350	1618	52	1914	620
ENST00000366542	CEP170	chr1	243349080	-	ENST00000487270	RAD51B	chr14	68758600	+	3410	1618	52	2016	654
ENST00000366542	CEP170	chr1	243349080	-	ENST00000488612	RAD51B	chr14	68758600	+	2385	1618	52	1962	636
ENST00000366542	CEP170	chr1	243349080	-	ENST00000390683	RAD51B	chr14	68758600	+	1963	1618	52	1962	637

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000366542	ENST00000487861	CEP170	chr1	243349080	-	RAD51B	chr14	68758600	+	0.005157399	0.9948426
ENST00000366542	ENST00000471583	CEP170	chr1	243349080	-	RAD51B	chr14	68758600	+	0.002588372	0.99741167
ENST00000366542	ENST00000487270	CEP170	chr1	243349080	-	RAD51B	chr14	68758600	+	0.001869261	0.99813074
ENST00000366542	ENST00000488612	CEP170	chr1	243349080	-	RAD51B	chr14	68758600	+	0.003489216	0.9965108
ENST00000366542	ENST00000390683	CEP170	chr1	243349080	-	RAD51B	chr14	68758600	+	0.003687553	0.99631244

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>15803_15803_1_CEP170-RAD51B_CEP170_chr1_243349080_ENST00000366542_RAD51B_chr14_68758600_ENST00000390683_length(amino acids)=637AA_BP=400
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVTSSAHHRGGHGVPHGKLLKQKSEEPS
VSIPFLQTALLRSSGSLGHRPSQEMDKMLKNQATSATSEKDNDDDQSDKGTYTIELENPNSEEVEARKMIDKVILTNQITTHLSGALASQ
ADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWHICISGFSIQNR

--------------------------------------------------------------

>15803_15803_2_CEP170-RAD51B_CEP170_chr1_243349080_ENST00000366542_RAD51B_chr14_68758600_ENST00000471583_length(amino acids)=620AA_BP=400
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVTSSAHHRGGHGVPHGKLLKQKSEEPS
VSIPFLQTALLRSSGSLGHRPSQEMDKMLKNQATSATSEKDNDDDQSDKGTYTIELENPNSEEVEARKMIDKVILTNQITTHLSGALASQ

--------------------------------------------------------------

>15803_15803_3_CEP170-RAD51B_CEP170_chr1_243349080_ENST00000366542_RAD51B_chr14_68758600_ENST00000487270_length(amino acids)=654AA_BP=400
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVTSSAHHRGGHGVPHGKLLKQKSEEPS
VSIPFLQTALLRSSGSLGHRPSQEMDKMLKNQATSATSEKDNDDDQSDKGTYTIELENPNSEEVEARKMIDKVILTNQITTHLSGALASQ
ADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQETTFCSVTQAELNWA

--------------------------------------------------------------

>15803_15803_4_CEP170-RAD51B_CEP170_chr1_243349080_ENST00000366542_RAD51B_chr14_68758600_ENST00000487861_length(amino acids)=695AA_BP=400
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVTSSAHHRGGHGVPHGKLLKQKSEEPS
VSIPFLQTALLRSSGSLGHRPSQEMDKMLKNQATSATSEKDNDDDQSDKGTYTIELENPNSEEVEARKMIDKVILTNQITTHLSGALASQ
ADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPRSECW

--------------------------------------------------------------

>15803_15803_5_CEP170-RAD51B_CEP170_chr1_243349080_ENST00000366542_RAD51B_chr14_68758600_ENST00000488612_length(amino acids)=636AA_BP=400
MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG
YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP
SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS
HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD
VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVTSSAHHRGGHGVPHGKLLKQKSEEPS
VSIPFLQTALLRSSGSLGHRPSQEMDKMLKNQATSATSEKDNDDDQSDKGTYTIELENPNSEEVEARKMIDKVILTNQITTHLSGALASQ
ADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWHICISGFSIQNR

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:243349080/chr14:68758600)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
CEP170 Q9Y4F5	RAD51B O15315
FUNCTION: Plays a role in microtubule organization. {ECO:0000250\|UniProtKB:Q5SW79}.	FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. {ECO:0000269\|PubMed:11751635, ECO:0000269\|PubMed:11751636, ECO:0000269\|PubMed:11842113, ECO:0000269\|PubMed:12441335, ECO:0000269\|PubMed:23108668, ECO:0000269\|PubMed:23149936}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CEP170

chr1:243349080

chr14:68758600

ENST00000366542

23_73

522.0

1585.0

Domain

FHA

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

CEP170

chr1:243349080

chr14:68758600

ENST00000366542

1467_1495

522.0

1585.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP170

chr1:243349080

chr14:68758600

ENST00000366543

1467_1495

1461.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP170

chr1:243349080

chr14:68758600

ENST00000366544

1467_1495

1487.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

CEP170

chr1:243349080

chr14:68758600

ENST00000366543

23_73

1461.0

Domain

FHA

Hgene

CEP170

chr1:243349080

chr14:68758600

ENST00000366544

23_73

1487.0

Domain

FHA

Hgene

CEP170

chr1:243349080

chr14:68758600

ENST00000366542

1113_1584

522.0

1585.0

Region

Note=Targeting to centrosomes

Hgene

CEP170

chr1:243349080

chr14:68758600

ENST00000366542

853_1584

522.0

1585.0

Region

Note=Targeting to microtubules

Hgene

CEP170

chr1:243349080

chr14:68758600

ENST00000366543

1113_1584

1461.0

Region

Note=Targeting to centrosomes

Hgene

CEP170

chr1:243349080

chr14:68758600

ENST00000366543

853_1584

1461.0

Region

Note=Targeting to microtubules

Hgene

CEP170

chr1:243349080

chr14:68758600

ENST00000366544

1113_1584

1487.0

Region

Note=Targeting to centrosomes

Hgene

CEP170

chr1:243349080

chr14:68758600

ENST00000366544

853_1584

1487.0

Region

Note=Targeting to microtubules

Tgene

RAD51B

chr1:243349080

chr14:68758600

ENST00000390683

108_115

252.0

367.0

Nucleotide binding

ATP

Tgene

RAD51B

chr1:243349080

chr14:68758600

ENST00000471583

108_115

252.0

351.0

Nucleotide binding

ATP

Tgene

RAD51B

chr1:243349080

chr14:68758600

ENST00000487270

108_115

252.0

385.0

Nucleotide binding

ATP

Tgene

RAD51B

chr1:243349080

chr14:68758600

ENST00000488612

108_115

252.0

495.6666666666667

Nucleotide binding

ATP

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1425_CEP170_243349080_RAD51B_68758600_ranked_0.pdb	CEP170	243349080	243349080	ENST00000390683	RAD51B	chr14	68758600	+	MSLTSWFLVSSGGTRHRLPREMIFVGRDDCELMLQSRSVDKQHAVINYDASTDEHLVKDLGSLNGTFVNDVRIPEQTYITLKLEDKLRFG YDTNLFTVVQGEMRVPEEALKHEKFTIQLQLSQKSSESELSKSASAKSIDSKVADAATEVQHKTTEALKSEEKAMDISAMPRGTPLYGQP SWWGDDEVDEKRAFKTNGKPEEKNHEAGTSGCGIDAKQVEEQSAAANEEVLFPFCREPSYFEIPTKEFQQPSQITESTIHEIPTKDTPSS HITGAGHASFTIEFDDSTPGKVTIRDHVTKFTSDQRHKSKKSSPGTQDLLGIQTGMMAPENKVADWLAQNNPPQMLWERTEEDSKSIKSD VPVYLKRLKGNKHDDGTQSDSENAGAHRRCSKRATLEEHLRRHHSEHKKLQKVQATEKHQDQAVTSSAHHRGGHGVPHGKLLKQKSEEPS VSIPFLQTALLRSSGSLGHRPSQEMDKMLKNQATSATSEKDNDDDQSDKGTYTIELENPNSEEVEARKMIDKVILTNQITTHLSGALASQ ADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPRSECW	695

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

CEP170_pLDDT.png

RAD51B_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
RAD51B	RAD51, RAD51C, RAD51D, XRCC2, SWSAP1, FAM9B, DKKL1, ARL4C, MUC20, ADAMTS4, HELQ, HNRNPL, SPDL1, BRCA1, TPT1, ABL1, MEOX2, RPAIN, ANAPC5, BAGE2, C15orf39, PRPF6, C5orf34, N4BP2L2, BANP, ANKHD1-EIF4EBP3, KLRC2, DSCC1, SATB2, ZNHIT6, PMS1, NUF2, APAF1, PRKACB, MAPRE2, CD300LB, PRKACG, TBC1D2B, MTR,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
CEP170
RAD51B

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	CEP170	chr1:243349080	chr14:68758600	ENST00000366542	-	10	20	1015_1460	522.0	1585.0	CCDC61
Hgene	CEP170	chr1:243349080	chr14:68758600	ENST00000366543	-	1	19	1015_1460	0	1461.0	CCDC61
Hgene	CEP170	chr1:243349080	chr14:68758600	ENST00000366544	-	1	19	1015_1460	0	1487.0	CCDC61
Tgene	RAD51B	chr1:243349080	chr14:68758600	ENST00000390683		5	10	1_75	252.0	367.0	RAD51C
Tgene	RAD51B	chr1:243349080	chr14:68758600	ENST00000471583		6	11	1_75	252.0	351.0	RAD51C
Tgene	RAD51B	chr1:243349080	chr14:68758600	ENST00000487270		6	11	1_75	252.0	385.0	RAD51C
Tgene	RAD51B	chr1:243349080	chr14:68758600	ENST00000488612		6	12	1_75	252.0	495.6666666666667	RAD51C

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Related Drugs to CEP170-RAD51B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to CEP170-RAD51B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	RAD51B	C0006142	Malignant neoplasm of breast	1	CTD_human
Tgene	RAD51B	C0013146	Drug abuse	1	CTD_human
Tgene	RAD51B	C0013170	Drug habituation	1	CTD_human
Tgene	RAD51B	C0013222	Drug Use Disorders	1	CTD_human
Tgene	RAD51B	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
Tgene	RAD51B	C0038580	Substance Dependence	1	CTD_human
Tgene	RAD51B	C0038586	Substance Use Disorders	1	CTD_human
Tgene	RAD51B	C0236969	Substance-Related Disorders	1	CTD_human
Tgene	RAD51B	C0238033	Carcinoma of Male Breast	1	CTD_human
Tgene	RAD51B	C0242788	Breast Neoplasms, Male	1	CTD_human
Tgene	RAD51B	C0678222	Breast Carcinoma	1	CTD_human
Tgene	RAD51B	C0740858	Substance abuse problem	1	CTD_human
Tgene	RAD51B	C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene	RAD51B	C1458155	Mammary Neoplasms	1	CTD_human
Tgene	RAD51B	C1510472	Drug Dependence	1	CTD_human
Tgene	RAD51B	C4316881	Prescription Drug Abuse	1	CTD_human
Tgene	RAD51B	C4704874	Mammary Carcinoma, Human	1	CTD_human