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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:DENND3-PTK2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: DENND3-PTK2
	FusionPDB ID: 22236
	FusionGDB2.0 ID: 22236
		Hgene	Tgene
	Gene symbol	DENND3	PTK2
	Gene ID	22898	5747
	Gene name	DENN domain containing 3	protein tyrosine kinase 2
	Synonyms	-	FADK\|FAK\|FAK1\|FRNK\|PPP1R71\|p125FAK\|pp125FAK
	Cytomap	8q24.3	8q24.3
	Type of gene	protein-coding	protein-coding
	Description	DENN domain-containing protein 3DENN/MADD domain containing 3	focal adhesion kinase 1FADK 1FAK-related non-kinase polypeptidePTK2 protein tyrosine kinase 2focal adhesion kinase isoform FAK-Del33focal adhesion kinase-related nonkinaseprotein phosphatase 1 regulatory subunit 71
	Modification date	20200313	20200327
	UniProtAcc	A2RUS2	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000262585, ENST00000424248, ENST00000519811, ENST00000518347, ENST00000518806, ENST00000523308,	ENST00000522950, ENST00000517712, ENST00000519635, ENST00000519881, ENST00000520151, ENST00000520892, ENST00000340930, ENST00000395218, ENST00000430260, ENST00000517887, ENST00000519419, ENST00000519465, ENST00000521059, ENST00000522684, ENST00000535192, ENST00000538769,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	4 X 4 X 3=48	19 X 20 X 13=4940
	# samples	4	29
	** MAII score	log2(4/48*10)=-0.263034405833794 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(29/4940*10)=-4.09038623645711 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: DENND3 [Title/Abstract] AND PTK2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	DENND3(142154358)-PTK2(141669777), # samples:3 PTK2(142011224)-DENND3(142146608), # samples:2
Anticipated loss of major functional domain due to fusion event.	DENND3-PTK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DENND3-PTK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DENND3-PTK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DENND3-PTK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DENND3-PTK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. DENND3-PTK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	PTK2	GO:0007179	transforming growth factor beta receptor signaling pathway	24036928
Tgene	PTK2	GO:0007229	integrin-mediated signaling pathway	24036928
Tgene	PTK2	GO:0010763	positive regulation of fibroblast migration	26763945
Tgene	PTK2	GO:0018108	peptidyl-tyrosine phosphorylation	10655584\|11331870
Tgene	PTK2	GO:0022408	negative regulation of cell-cell adhesion	21703394
Tgene	PTK2	GO:0030335	positive regulation of cell migration	11331870\|21703394
Tgene	PTK2	GO:0033628	regulation of cell adhesion mediated by integrin	10655584
Tgene	PTK2	GO:0046777	protein autophosphorylation	10655584\|11331870
Tgene	PTK2	GO:0048013	ephrin receptor signaling pathway	10655584
Tgene	PTK2	GO:0060396	growth hormone receptor signaling pathway	10925297
Tgene	PTK2	GO:0090303	positive regulation of wound healing	26763945

Fusion gene breakpoints across DENND3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PTK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	GBM	TCGA-26-5133-01A	DENND3	chr8	142154358	+	PTK2	chr8	141669777	-
ChimerDB4	GBM	TCGA-26-5133	DENND3	chr8	142154358	+	PTK2	chr8	141669777	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000424248	DENND3	chr8	142154358	+	ENST00000535192	PTK2	chr8	141669777	-	2061	773	140	985	281
ENST00000424248	DENND3	chr8	142154358	+	ENST00000538769	PTK2	chr8	141669777	-	2047	773	140	985	281
ENST00000262585	DENND3	chr8	142154358	+	ENST00000535192	PTK2	chr8	141669777	-	2061	773	140	985	281
ENST00000262585	DENND3	chr8	142154358	+	ENST00000538769	PTK2	chr8	141669777	-	2047	773	140	985	281
ENST00000519811	DENND3	chr8	142154358	+	ENST00000535192	PTK2	chr8	141669777	-	2093	805	70	1017	315
ENST00000519811	DENND3	chr8	142154358	+	ENST00000538769	PTK2	chr8	141669777	-	2079	805	70	1017	315

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000424248	ENST00000535192	DENND3	chr8	142154358	+	PTK2	chr8	141669777	-	0.012259816	0.9877402
ENST00000424248	ENST00000538769	DENND3	chr8	142154358	+	PTK2	chr8	141669777	-	0.012594891	0.9874051
ENST00000262585	ENST00000535192	DENND3	chr8	142154358	+	PTK2	chr8	141669777	-	0.012259816	0.9877402
ENST00000262585	ENST00000538769	DENND3	chr8	142154358	+	PTK2	chr8	141669777	-	0.012594891	0.9874051
ENST00000519811	ENST00000535192	DENND3	chr8	142154358	+	PTK2	chr8	141669777	-	0.000427619	0.99957234
ENST00000519811	ENST00000538769	DENND3	chr8	142154358	+	PTK2	chr8	141669777	-	0.000462308	0.9995377

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>22236_22236_1_DENND3-PTK2_DENND3_chr8_142154358_ENST00000262585_PTK2_chr8_141669777_ENST00000535192_length(amino acids)=281AA_BP=197
MRAAGRPPGQSPKSRAEVLSIFVPPFISKEDSQMAGANCGTLGKTRMRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQ
LCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLK
PCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQA

--------------------------------------------------------------

>22236_22236_2_DENND3-PTK2_DENND3_chr8_142154358_ENST00000262585_PTK2_chr8_141669777_ENST00000538769_length(amino acids)=281AA_BP=197
MRAAGRPPGQSPKSRAEVLSIFVPPFISKEDSQMAGANCGTLGKTRMRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQ
LCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLK
PCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQA

--------------------------------------------------------------

>22236_22236_3_DENND3-PTK2_DENND3_chr8_142154358_ENST00000424248_PTK2_chr8_141669777_ENST00000535192_length(amino acids)=281AA_BP=197
MRAAGRPPGQSPKSRAEVLSIFVPPFISKEDSQMAGANCGTLGKTRMRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQ
LCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLK
PCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQA

--------------------------------------------------------------

>22236_22236_4_DENND3-PTK2_DENND3_chr8_142154358_ENST00000424248_PTK2_chr8_141669777_ENST00000538769_length(amino acids)=281AA_BP=197
MRAAGRPPGQSPKSRAEVLSIFVPPFISKEDSQMAGANCGTLGKTRMRSLRKKREKPRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQ
LCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRECPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLK
PCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLIEMAQKLLNSDLGELINKMKLAQQYVMTSLQQEYKKQMLTAAHALAVDAKNLLDVIDQA

--------------------------------------------------------------

>22236_22236_5_DENND3-PTK2_DENND3_chr8_142154358_ENST00000519811_PTK2_chr8_141669777_ENST00000535192_length(amino acids)=315AA_BP=231
MAEAASPHLSLPSGLLELCALLGAPRDSLRSLEQVAYKKGVKHLSALLDPEVLSIFVPPFISKEDSQMAGANCGTLGKTRMRSLRKKREK
PRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRE
CPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLIEMAQKLLNSDLGELINKMKLAQQY

--------------------------------------------------------------

>22236_22236_6_DENND3-PTK2_DENND3_chr8_142154358_ENST00000519811_PTK2_chr8_141669777_ENST00000538769_length(amino acids)=315AA_BP=231
MAEAASPHLSLPSGLLELCALLGAPRDSLRSLEQVAYKKGVKHLSALLDPEVLSIFVPPFISKEDSQMAGANCGTLGKTRMRSLRKKREK
PRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRE
CPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLIEMAQKLLNSDLGELINKMKLAQQY

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:142154358/chr8:141669777)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DENND3 A2RUS2	.
FUNCTION: Guanine nucleotide exchange factor (GEF) activating RAB12. Promotes the exchange of GDP to GTP, converting inactive GDP-bound RAB12 into its active GTP-bound form (PubMed:20937701). Regulates autophagy in response to starvation through RAB12 activation. Starvation leads to ULK1/2-dependent phosphorylation of Ser-472 and Ser-490, which in turn allows recruitment of 14-3-3 adapter proteins and leads to up-regulation of GEF activity towards RAB12 (By similarity). Also plays a role in protein transport from recycling endosomes to lysosomes, regulating, for instance, the degradation of the transferrin receptor and of the amino acid transporter PAT4 (PubMed:20937701). Starvation also induces phosphorylation at Tyr-858, which leads to up-regulated GEF activity and initiates autophagy (By similarity). {ECO:0000250\|UniProtKB:A2RT67, ECO:0000269\|PubMed:20937701}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DENND3

chr8:142154358

chr8:141669777

ENST00000262585

1_163

165.0

1199.0

Domain

uDENN

Hgene

DENND3

chr8:142154358

chr8:141669777

ENST00000424248

1_163

165.0

1147.0

Domain

uDENN

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DENND3

chr8:142154358

chr8:141669777

ENST00000262585

186_318

165.0

1199.0

Domain

cDENN

Hgene

DENND3

chr8:142154358

chr8:141669777

ENST00000262585

320_424

165.0

1199.0

Domain

dDENN

Hgene

DENND3

chr8:142154358

chr8:141669777

ENST00000424248

186_318

165.0

1147.0

Domain

cDENN

Hgene

DENND3

chr8:142154358

chr8:141669777

ENST00000424248

320_424

165.0

1147.0

Domain

dDENN

Hgene

DENND3

chr8:142154358

chr8:141669777

ENST00000262585

438_888

165.0

1199.0

Region

Linker

Hgene

DENND3

chr8:142154358

chr8:141669777

ENST00000424248

438_888

165.0

1147.0

Region

Linker

Hgene

DENND3

chr8:142154358

chr8:141669777

ENST00000262585

1022_1059

165.0

1199.0

Repeat

WD 4

Hgene

DENND3

chr8:142154358

chr8:141669777

ENST00000262585

1065_1105

165.0

1199.0

Repeat

WD 5

Hgene

DENND3

chr8:142154358

chr8:141669777

ENST00000262585

1110_1152

165.0

1199.0

Repeat

WD 6

Hgene

DENND3

chr8:142154358

chr8:141669777

ENST00000262585

1158_1197

165.0

1199.0

Repeat

WD 7

Hgene

DENND3

chr8:142154358

chr8:141669777

ENST00000262585

893_931

165.0

1199.0

Repeat

WD 1

Hgene

DENND3

chr8:142154358

chr8:141669777

ENST00000262585

937_973

165.0

1199.0

Repeat

WD 2

Hgene

DENND3

chr8:142154358

chr8:141669777

ENST00000262585

977_1018

165.0

1199.0

Repeat

WD 3

Hgene

DENND3

chr8:142154358

chr8:141669777

ENST00000424248

1022_1059

165.0

1147.0

Repeat

WD 4

Hgene

DENND3

chr8:142154358

chr8:141669777

ENST00000424248

1065_1105

165.0

1147.0

Repeat

WD 5

Hgene

DENND3

chr8:142154358

chr8:141669777

ENST00000424248

1110_1152

165.0

1147.0

Repeat

WD 6

Hgene

DENND3

chr8:142154358

chr8:141669777

ENST00000424248

1158_1197

165.0

1147.0

Repeat

WD 7

Hgene

DENND3

chr8:142154358

chr8:141669777

ENST00000424248

893_931

165.0

1147.0

Repeat

WD 1

Hgene

DENND3

chr8:142154358

chr8:141669777

ENST00000424248

937_973

165.0

1147.0

Repeat

WD 2

Hgene

DENND3

chr8:142154358

chr8:141669777

ENST00000424248

977_1018

165.0

1147.0

Repeat

WD 3

Tgene

PTK2

chr8:142154358

chr8:141669777

ENST00000340930

712_733

995.0

1066.0

Compositional bias

Note=Pro-rich

Tgene

PTK2

chr8:142154358

chr8:141669777

ENST00000340930

863_913

995.0

1066.0

Compositional bias

Note=Pro-rich

Tgene

PTK2

chr8:142154358

chr8:141669777

ENST00000521059

712_733

982.0

1053.0

Compositional bias

Note=Pro-rich

Tgene

PTK2

chr8:142154358

chr8:141669777

ENST00000521059

863_913

982.0

1053.0

Compositional bias

Note=Pro-rich

Tgene

PTK2

chr8:142154358

chr8:141669777

ENST00000522684

712_733

982.0

1053.0

Compositional bias

Note=Pro-rich

Tgene

PTK2

chr8:142154358

chr8:141669777

ENST00000522684

863_913

982.0

1053.0

Compositional bias

Note=Pro-rich

Tgene

PTK2

chr8:142154358

chr8:141669777

ENST00000340930

35_355

995.0

1066.0

Domain

FERM

Tgene

PTK2

chr8:142154358

chr8:141669777

ENST00000340930

422_680

995.0

1066.0

Domain

Protein kinase

Tgene

PTK2

chr8:142154358

chr8:141669777

ENST00000521059

35_355

982.0

1053.0

Domain

FERM

Tgene

PTK2

chr8:142154358

chr8:141669777

ENST00000521059

422_680

982.0

1053.0

Domain

Protein kinase

Tgene

PTK2

chr8:142154358

chr8:141669777

ENST00000522684

35_355

982.0

1053.0

Domain

FERM

Tgene

PTK2

chr8:142154358

chr8:141669777

ENST00000522684

422_680

982.0

1053.0

Domain

Protein kinase

Tgene

PTK2

chr8:142154358

chr8:141669777

ENST00000340930

428_434

995.0

1066.0

Nucleotide binding

ATP

Tgene

PTK2

chr8:142154358

chr8:141669777

ENST00000340930

500_502

995.0

1066.0

Nucleotide binding

ATP

Tgene

PTK2

chr8:142154358

chr8:141669777

ENST00000521059

428_434

982.0

1053.0

Nucleotide binding

ATP

Tgene

PTK2

chr8:142154358

chr8:141669777

ENST00000521059

500_502

982.0

1053.0

Nucleotide binding

ATP

Tgene

PTK2

chr8:142154358

chr8:141669777

ENST00000522684

428_434

982.0

1053.0

Nucleotide binding

ATP

Tgene

PTK2

chr8:142154358

chr8:141669777

ENST00000522684

500_502

982.0

1053.0

Nucleotide binding

ATP

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>577_DENND3_142154358_PTK2_141669777_ranked_0.pdb	DENND3	142154358	142154358	ENST00000538769	PTK2	chr8	141669777	-	MAEAASPHLSLPSGLLELCALLGAPRDSLRSLEQVAYKKGVKHLSALLDPEVLSIFVPPFISKEDSQMAGANCGTLGKTRMRSLRKKREK PRPEQWKGLPGPPRAPEPEDVAVPGGVDLLTLPQLCFPGGVCVATEPKEDCVHFLVLTDVCGNRTYGVVAQYYRPLHDEYCFYNGKTHRE CPGCFVPFAVCVVSRFPYYNSLKDCLSCLLALLKPCKDFEVDSHIKDFAAKLSLIPSPPPGPLHLIEMAQKLLNSDLGELINKMKLAQQY	315

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

DENND3_pLDDT.png

PTK2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
DENND3
PTK2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	PTK2	chr8:142154358	chr8:141669777	ENST00000340930		31	33	912_1052	995.0	1066.0	ARHGEF28
Tgene	PTK2	chr8:142154358	chr8:141669777	ENST00000521059		30	32	912_1052	982.0	1053.0	ARHGEF28
Tgene	PTK2	chr8:142154358	chr8:141669777	ENST00000522684		30	32	912_1052	982.0	1053.0	ARHGEF28

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Related Drugs to DENND3-PTK2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to DENND3-PTK2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source