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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:DSTYK-CSRP1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: DSTYK-CSRP1
	FusionPDB ID: 24327
	FusionGDB2.0 ID: 24327
		Hgene	Tgene
	Gene symbol	DSTYK	CSRP1
	Gene ID	25778	1465
	Gene name	dual serine/threonine and tyrosine protein kinase	cysteine and glycine rich protein 1
	Synonyms	CAKUT1\|DustyPK\|HDCMD38P\|RIP5\|RIPK5\|SPG23	CRP\|CRP1\|CSRP\|CYRP\|D1S181E\|HEL-141\|HEL-S-286
	Cytomap	1q32.1	1q32.1
	Type of gene	protein-coding	protein-coding
	Description	dual serine/threonine and tyrosine protein kinaseRIP-homologous kinasedusty PKdusty protein kinasereceptor-interacting serine/threonine-protein kinase 5sgK496spastic paraplegia 23 (autosomal recessive)sugen kinase 496	cysteine and glycine-rich protein 1LIM-domain proteincysteine-rich protein 1epididymis luminal protein 141epididymis secretory protein Li 286epididymis secretory sperm binding protein
	Modification date	20200313	20200313
	UniProtAcc	Q6XUX3	P21291
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000367160, ENST00000367161, ENST00000367162,	ENST00000458271, ENST00000526723, ENST00000531916, ENST00000532460, ENST00000533432, ENST00000340006, ENST00000367306,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	8 X 5 X 7=280	7 X 9 X 5=315
	# samples	11	11
	** MAII score	log2(11/280*10)=-1.34792330342031 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(11/315*10)=-1.51784830486262 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: DSTYK [Title/Abstract] AND CSRP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	DSTYK(205180399)-CSRP1(201454504), # samples:3
Anticipated loss of major functional domain due to fusion event.	DSTYK-CSRP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DSTYK-CSRP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. DSTYK-CSRP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. DSTYK-CSRP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	DSTYK	GO:0044344	cellular response to fibroblast growth factor stimulus	23862974

Fusion gene breakpoints across DSTYK (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across CSRP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCS	TCGA-N8-A56S-01A	DSTYK	chr1	205180399	-	CSRP1	chr1	201454504	-
ChimerDB4	UCS	TCGA-N8-A56S	DSTYK	chr1	205180398	-	CSRP1	chr1	201454504	-
ChimerDB4	UCS	TCGA-N8-A56S	DSTYK	chr1	205180399	-	CSRP1	chr1	201454504	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000367160	DSTYK	chr1	205180399	-	ENST00000367306	CSRP1	chr1	201454504	-	1683	329	84	665	193
ENST00000367160	DSTYK	chr1	205180399	-	ENST00000340006	CSRP1	chr1	201454504	-	1679	329	84	665	193
ENST00000367161	DSTYK	chr1	205180399	-	ENST00000367306	CSRP1	chr1	201454504	-	1650	296	51	632	193
ENST00000367161	DSTYK	chr1	205180399	-	ENST00000340006	CSRP1	chr1	201454504	-	1646	296	51	632	193
ENST00000367162	DSTYK	chr1	205180399	-	ENST00000367306	CSRP1	chr1	201454504	-	1650	296	51	632	193
ENST00000367162	DSTYK	chr1	205180399	-	ENST00000340006	CSRP1	chr1	201454504	-	1646	296	51	632	193
ENST00000367160	DSTYK	chr1	205180398	-	ENST00000367306	CSRP1	chr1	201454504	-	1683	329	84	665	193
ENST00000367160	DSTYK	chr1	205180398	-	ENST00000340006	CSRP1	chr1	201454504	-	1679	329	84	665	193
ENST00000367161	DSTYK	chr1	205180398	-	ENST00000367306	CSRP1	chr1	201454504	-	1650	296	51	632	193
ENST00000367161	DSTYK	chr1	205180398	-	ENST00000340006	CSRP1	chr1	201454504	-	1646	296	51	632	193
ENST00000367162	DSTYK	chr1	205180398	-	ENST00000367306	CSRP1	chr1	201454504	-	1650	296	51	632	193
ENST00000367162	DSTYK	chr1	205180398	-	ENST00000340006	CSRP1	chr1	201454504	-	1646	296	51	632	193

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000367160	ENST00000367306	DSTYK	chr1	205180399	-	CSRP1	chr1	201454504	-	0.576351	0.423649
ENST00000367160	ENST00000340006	DSTYK	chr1	205180399	-	CSRP1	chr1	201454504	-	0.5814876	0.4185124
ENST00000367161	ENST00000367306	DSTYK	chr1	205180399	-	CSRP1	chr1	201454504	-	0.6122478	0.38775215
ENST00000367161	ENST00000340006	DSTYK	chr1	205180399	-	CSRP1	chr1	201454504	-	0.6182326	0.3817674
ENST00000367162	ENST00000367306	DSTYK	chr1	205180399	-	CSRP1	chr1	201454504	-	0.6122478	0.38775215
ENST00000367162	ENST00000340006	DSTYK	chr1	205180399	-	CSRP1	chr1	201454504	-	0.6182326	0.3817674
ENST00000367160	ENST00000367306	DSTYK	chr1	205180398	-	CSRP1	chr1	201454504	-	0.576351	0.423649
ENST00000367160	ENST00000340006	DSTYK	chr1	205180398	-	CSRP1	chr1	201454504	-	0.5814876	0.4185124
ENST00000367161	ENST00000367306	DSTYK	chr1	205180398	-	CSRP1	chr1	201454504	-	0.6122478	0.38775215
ENST00000367161	ENST00000340006	DSTYK	chr1	205180398	-	CSRP1	chr1	201454504	-	0.6182326	0.3817674
ENST00000367162	ENST00000367306	DSTYK	chr1	205180398	-	CSRP1	chr1	201454504	-	0.6122478	0.38775215
ENST00000367162	ENST00000340006	DSTYK	chr1	205180398	-	CSRP1	chr1	201454504	-	0.6182326	0.3817674

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>24327_24327_1_DSTYK-CSRP1_DSTYK_chr1_205180398_ENST00000367160_CSRP1_chr1_201454504_ENST00000340006_length(amino acids)=193AA_BP=77
MGQRARLGSRPRRRRNDPRAVPGLRPLPPLPGTAATEPARDPEVLPRHQVLPQPHLSLLPHGRRRGRARPCRRCRRNRAAGGPGIRPAFD
VPSVAKALSQPPWQTRMARFTAKDVMLKTSGPRALVLGKELGPWSTLSEATITHHTLPTPALFIAIPFPAALETSRIISLSALPHITNDL

--------------------------------------------------------------

>24327_24327_2_DSTYK-CSRP1_DSTYK_chr1_205180398_ENST00000367160_CSRP1_chr1_201454504_ENST00000367306_length(amino acids)=193AA_BP=77
MGQRARLGSRPRRRRNDPRAVPGLRPLPPLPGTAATEPARDPEVLPRHQVLPQPHLSLLPHGRRRGRARPCRRCRRNRAAGGPGIRPAFD
VPSVAKALSQPPWQTRMARFTAKDVMLKTSGPRALVLGKELGPWSTLSEATITHHTLPTPALFIAIPFPAALETSRIISLSALPHITNDL

--------------------------------------------------------------

>24327_24327_3_DSTYK-CSRP1_DSTYK_chr1_205180398_ENST00000367161_CSRP1_chr1_201454504_ENST00000340006_length(amino acids)=193AA_BP=77
MGQRARLGSRPRRRRNDPRAVPGLRPLPPLPGTAATEPARDPEVLPRHQVLPQPHLSLLPHGRRRGRARPCRRCRRNRAAGGPGIRPAFD
VPSVAKALSQPPWQTRMARFTAKDVMLKTSGPRALVLGKELGPWSTLSEATITHHTLPTPALFIAIPFPAALETSRIISLSALPHITNDL

--------------------------------------------------------------

>24327_24327_4_DSTYK-CSRP1_DSTYK_chr1_205180398_ENST00000367161_CSRP1_chr1_201454504_ENST00000367306_length(amino acids)=193AA_BP=77
MGQRARLGSRPRRRRNDPRAVPGLRPLPPLPGTAATEPARDPEVLPRHQVLPQPHLSLLPHGRRRGRARPCRRCRRNRAAGGPGIRPAFD
VPSVAKALSQPPWQTRMARFTAKDVMLKTSGPRALVLGKELGPWSTLSEATITHHTLPTPALFIAIPFPAALETSRIISLSALPHITNDL

--------------------------------------------------------------

>24327_24327_5_DSTYK-CSRP1_DSTYK_chr1_205180398_ENST00000367162_CSRP1_chr1_201454504_ENST00000340006_length(amino acids)=193AA_BP=77
MGQRARLGSRPRRRRNDPRAVPGLRPLPPLPGTAATEPARDPEVLPRHQVLPQPHLSLLPHGRRRGRARPCRRCRRNRAAGGPGIRPAFD
VPSVAKALSQPPWQTRMARFTAKDVMLKTSGPRALVLGKELGPWSTLSEATITHHTLPTPALFIAIPFPAALETSRIISLSALPHITNDL

--------------------------------------------------------------

>24327_24327_6_DSTYK-CSRP1_DSTYK_chr1_205180398_ENST00000367162_CSRP1_chr1_201454504_ENST00000367306_length(amino acids)=193AA_BP=77
MGQRARLGSRPRRRRNDPRAVPGLRPLPPLPGTAATEPARDPEVLPRHQVLPQPHLSLLPHGRRRGRARPCRRCRRNRAAGGPGIRPAFD
VPSVAKALSQPPWQTRMARFTAKDVMLKTSGPRALVLGKELGPWSTLSEATITHHTLPTPALFIAIPFPAALETSRIISLSALPHITNDL

--------------------------------------------------------------

>24327_24327_7_DSTYK-CSRP1_DSTYK_chr1_205180399_ENST00000367160_CSRP1_chr1_201454504_ENST00000340006_length(amino acids)=193AA_BP=77
MGQRARLGSRPRRRRNDPRAVPGLRPLPPLPGTAATEPARDPEVLPRHQVLPQPHLSLLPHGRRRGRARPCRRCRRNRAAGGPGIRPAFD
VPSVAKALSQPPWQTRMARFTAKDVMLKTSGPRALVLGKELGPWSTLSEATITHHTLPTPALFIAIPFPAALETSRIISLSALPHITNDL

--------------------------------------------------------------

>24327_24327_8_DSTYK-CSRP1_DSTYK_chr1_205180399_ENST00000367160_CSRP1_chr1_201454504_ENST00000367306_length(amino acids)=193AA_BP=77
MGQRARLGSRPRRRRNDPRAVPGLRPLPPLPGTAATEPARDPEVLPRHQVLPQPHLSLLPHGRRRGRARPCRRCRRNRAAGGPGIRPAFD
VPSVAKALSQPPWQTRMARFTAKDVMLKTSGPRALVLGKELGPWSTLSEATITHHTLPTPALFIAIPFPAALETSRIISLSALPHITNDL

--------------------------------------------------------------

>24327_24327_9_DSTYK-CSRP1_DSTYK_chr1_205180399_ENST00000367161_CSRP1_chr1_201454504_ENST00000340006_length(amino acids)=193AA_BP=77
MGQRARLGSRPRRRRNDPRAVPGLRPLPPLPGTAATEPARDPEVLPRHQVLPQPHLSLLPHGRRRGRARPCRRCRRNRAAGGPGIRPAFD
VPSVAKALSQPPWQTRMARFTAKDVMLKTSGPRALVLGKELGPWSTLSEATITHHTLPTPALFIAIPFPAALETSRIISLSALPHITNDL

--------------------------------------------------------------

>24327_24327_10_DSTYK-CSRP1_DSTYK_chr1_205180399_ENST00000367161_CSRP1_chr1_201454504_ENST00000367306_length(amino acids)=193AA_BP=77
MGQRARLGSRPRRRRNDPRAVPGLRPLPPLPGTAATEPARDPEVLPRHQVLPQPHLSLLPHGRRRGRARPCRRCRRNRAAGGPGIRPAFD
VPSVAKALSQPPWQTRMARFTAKDVMLKTSGPRALVLGKELGPWSTLSEATITHHTLPTPALFIAIPFPAALETSRIISLSALPHITNDL

--------------------------------------------------------------

>24327_24327_11_DSTYK-CSRP1_DSTYK_chr1_205180399_ENST00000367162_CSRP1_chr1_201454504_ENST00000340006_length(amino acids)=193AA_BP=77
MGQRARLGSRPRRRRNDPRAVPGLRPLPPLPGTAATEPARDPEVLPRHQVLPQPHLSLLPHGRRRGRARPCRRCRRNRAAGGPGIRPAFD
VPSVAKALSQPPWQTRMARFTAKDVMLKTSGPRALVLGKELGPWSTLSEATITHHTLPTPALFIAIPFPAALETSRIISLSALPHITNDL

--------------------------------------------------------------

>24327_24327_12_DSTYK-CSRP1_DSTYK_chr1_205180399_ENST00000367162_CSRP1_chr1_201454504_ENST00000367306_length(amino acids)=193AA_BP=77
MGQRARLGSRPRRRRNDPRAVPGLRPLPPLPGTAATEPARDPEVLPRHQVLPQPHLSLLPHGRRRGRARPCRRCRRNRAAGGPGIRPAFD
VPSVAKALSQPPWQTRMARFTAKDVMLKTSGPRALVLGKELGPWSTLSEATITHHTLPTPALFIAIPFPAALETSRIISLSALPHITNDL

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:205180399/chr1:201454504)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
DSTYK Q6XUX3	CSRP1 P21291
FUNCTION: Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269\|PubMed:15178406, ECO:0000269\|PubMed:23862974, ECO:0000269\|PubMed:28157540}.	FUNCTION: Could play a role in neuronal development.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DSTYK

chr1:205180398

chr1:201454504

ENST00000367161

15_22

88.33333333333333

885.0

Compositional bias

Note=Poly-Gly

Hgene

DSTYK

chr1:205180398

chr1:201454504

ENST00000367161

69_72

88.33333333333333

885.0

Compositional bias

Note=Poly-Gly

Hgene

DSTYK

chr1:205180398

chr1:201454504

ENST00000367162

15_22

88.33333333333333

930.0

Compositional bias

Note=Poly-Gly

Hgene

DSTYK

chr1:205180398

chr1:201454504

ENST00000367162

69_72

88.33333333333333

930.0

Compositional bias

Note=Poly-Gly

Hgene

DSTYK

chr1:205180399

chr1:201454504

ENST00000367161

15_22

88.33333333333333

885.0

Compositional bias

Note=Poly-Gly

Hgene

DSTYK

chr1:205180399

chr1:201454504

ENST00000367161

69_72

88.33333333333333

885.0

Compositional bias

Note=Poly-Gly

Hgene

DSTYK

chr1:205180399

chr1:201454504

ENST00000367162

15_22

88.33333333333333

930.0

Compositional bias

Note=Poly-Gly

Hgene

DSTYK

chr1:205180399

chr1:201454504

ENST00000367162

69_72

88.33333333333333

930.0

Compositional bias

Note=Poly-Gly

Tgene

CSRP1

chr1:205180398

chr1:201454504

ENST00000340006

176_187

137.0

194.0

Compositional bias

Note=Gly-rich

Tgene

CSRP1

chr1:205180398

chr1:201454504

ENST00000367306

176_187

137.0

194.0

Compositional bias

Note=Gly-rich

Tgene

CSRP1

chr1:205180398

chr1:201454504

ENST00000532460

176_187

137.0

194.0

Compositional bias

Note=Gly-rich

Tgene

CSRP1

chr1:205180398

chr1:201454504

ENST00000533432

176_187

137.0

194.0

Compositional bias

Note=Gly-rich

Tgene

CSRP1

chr1:205180399

chr1:201454504

ENST00000340006

176_187

137.0

194.0

Compositional bias

Note=Gly-rich

Tgene

CSRP1

chr1:205180399

chr1:201454504

ENST00000367306

176_187

137.0

194.0

Compositional bias

Note=Gly-rich

Tgene

CSRP1

chr1:205180399

chr1:201454504

ENST00000532460

176_187

137.0

194.0

Compositional bias

Note=Gly-rich

Tgene

CSRP1

chr1:205180399

chr1:201454504

ENST00000533432

176_187

137.0

194.0

Compositional bias

Note=Gly-rich

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

DSTYK

chr1:205180398

chr1:201454504

ENST00000367161

189_215

88.33333333333333

885.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DSTYK

chr1:205180398

chr1:201454504

ENST00000367161

395_431

88.33333333333333

885.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DSTYK

chr1:205180398

chr1:201454504

ENST00000367162

189_215

88.33333333333333

930.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DSTYK

chr1:205180398

chr1:201454504

ENST00000367162

395_431

88.33333333333333

930.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DSTYK

chr1:205180399

chr1:201454504

ENST00000367161

189_215

88.33333333333333

885.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DSTYK

chr1:205180399

chr1:201454504

ENST00000367161

395_431

88.33333333333333

885.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DSTYK

chr1:205180399

chr1:201454504

ENST00000367162

189_215

88.33333333333333

930.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DSTYK

chr1:205180399

chr1:201454504

ENST00000367162

395_431

88.33333333333333

930.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

DSTYK

chr1:205180398

chr1:201454504

ENST00000367161

652_906

88.33333333333333

885.0

Domain

Protein kinase

Hgene

DSTYK

chr1:205180398

chr1:201454504

ENST00000367162

652_906

88.33333333333333

930.0

Domain

Protein kinase

Hgene

DSTYK

chr1:205180399

chr1:201454504

ENST00000367161

652_906

88.33333333333333

885.0

Domain

Protein kinase

Hgene

DSTYK

chr1:205180399

chr1:201454504

ENST00000367162

652_906

88.33333333333333

930.0

Domain

Protein kinase

Hgene

DSTYK

chr1:205180398

chr1:201454504

ENST00000367161

658_666

88.33333333333333

885.0

Nucleotide binding

ATP

Hgene

DSTYK

chr1:205180398

chr1:201454504

ENST00000367162

658_666

88.33333333333333

930.0

Nucleotide binding

ATP

Hgene

DSTYK

chr1:205180399

chr1:201454504

ENST00000367161

658_666

88.33333333333333

885.0

Nucleotide binding

ATP

Hgene

DSTYK

chr1:205180399

chr1:201454504

ENST00000367162

658_666

88.33333333333333

930.0

Nucleotide binding

ATP

Tgene

CSRP1

chr1:205180398

chr1:201454504

ENST00000340006

63_78

137.0

194.0

Compositional bias

Note=Gly-rich

Tgene

CSRP1

chr1:205180398

chr1:201454504

ENST00000367306

63_78

137.0

194.0

Compositional bias

Note=Gly-rich

Tgene

CSRP1

chr1:205180398

chr1:201454504

ENST00000532460

63_78

137.0

194.0

Compositional bias

Note=Gly-rich

Tgene

CSRP1

chr1:205180398

chr1:201454504

ENST00000533432

63_78

137.0

194.0

Compositional bias

Note=Gly-rich

Tgene

CSRP1

chr1:205180399

chr1:201454504

ENST00000340006

63_78

137.0

194.0

Compositional bias

Note=Gly-rich

Tgene

CSRP1

chr1:205180399

chr1:201454504

ENST00000367306

63_78

137.0

194.0

Compositional bias

Note=Gly-rich

Tgene

CSRP1

chr1:205180399

chr1:201454504

ENST00000532460

63_78

137.0

194.0

Compositional bias

Note=Gly-rich

Tgene

CSRP1

chr1:205180399

chr1:201454504

ENST00000533432

63_78

137.0

194.0

Compositional bias

Note=Gly-rich

Tgene

CSRP1

chr1:205180398

chr1:201454504

ENST00000340006

10_61

137.0

194.0

Domain

LIM zinc-binding 1

Tgene

CSRP1

chr1:205180398

chr1:201454504

ENST00000340006

119_170

137.0

194.0

Domain

LIM zinc-binding 2

Tgene

CSRP1

chr1:205180398

chr1:201454504

ENST00000367306

10_61

137.0

194.0

Domain

LIM zinc-binding 1

Tgene

CSRP1

chr1:205180398

chr1:201454504

ENST00000367306

119_170

137.0

194.0

Domain

LIM zinc-binding 2

Tgene

CSRP1

chr1:205180398

chr1:201454504

ENST00000532460

10_61

137.0

194.0

Domain

LIM zinc-binding 1

Tgene

CSRP1

chr1:205180398

chr1:201454504

ENST00000532460

119_170

137.0

194.0

Domain

LIM zinc-binding 2

Tgene

CSRP1

chr1:205180398

chr1:201454504

ENST00000533432

10_61

137.0

194.0

Domain

LIM zinc-binding 1

Tgene

CSRP1

chr1:205180398

chr1:201454504

ENST00000533432

119_170

137.0

194.0

Domain

LIM zinc-binding 2

Tgene

CSRP1

chr1:205180399

chr1:201454504

ENST00000340006

10_61

137.0

194.0

Domain

LIM zinc-binding 1

Tgene

CSRP1

chr1:205180399

chr1:201454504

ENST00000340006

119_170

137.0

194.0

Domain

LIM zinc-binding 2

Tgene

CSRP1

chr1:205180399

chr1:201454504

ENST00000367306

10_61

137.0

194.0

Domain

LIM zinc-binding 1

Tgene

CSRP1

chr1:205180399

chr1:201454504

ENST00000367306

119_170

137.0

194.0

Domain

LIM zinc-binding 2

Tgene

CSRP1

chr1:205180399

chr1:201454504

ENST00000532460

10_61

137.0

194.0

Domain

LIM zinc-binding 1

Tgene

CSRP1

chr1:205180399

chr1:201454504

ENST00000532460

119_170

137.0

194.0

Domain

LIM zinc-binding 2

Tgene

CSRP1

chr1:205180399

chr1:201454504

ENST00000533432

10_61

137.0

194.0

Domain

LIM zinc-binding 1

Tgene

CSRP1

chr1:205180399

chr1:201454504

ENST00000533432

119_170

137.0

194.0

Domain

LIM zinc-binding 2

Tgene

CSRP1

chr1:205180398

chr1:201454504

ENST00000340006

64_69

137.0

194.0

Motif

Nuclear localization signal

Tgene

CSRP1

chr1:205180398

chr1:201454504

ENST00000367306

64_69

137.0

194.0

Motif

Nuclear localization signal

Tgene

CSRP1

chr1:205180398

chr1:201454504

ENST00000532460

64_69

137.0

194.0

Motif

Nuclear localization signal

Tgene

CSRP1

chr1:205180398

chr1:201454504

ENST00000533432

64_69

137.0

194.0

Motif

Nuclear localization signal

Tgene

CSRP1

chr1:205180399

chr1:201454504

ENST00000340006

64_69

137.0

194.0

Motif

Nuclear localization signal

Tgene

CSRP1

chr1:205180399

chr1:201454504

ENST00000367306

64_69

137.0

194.0

Motif

Nuclear localization signal

Tgene

CSRP1

chr1:205180399

chr1:201454504

ENST00000532460

64_69

137.0

194.0

Motif

Nuclear localization signal

Tgene

CSRP1

chr1:205180399

chr1:201454504

ENST00000533432

64_69

137.0

194.0

Motif

Nuclear localization signal

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>240_DSTYK_205180399_CSRP1_201454504_ranked_0.pdb	DSTYK	205180398	205180399	ENST00000340006	CSRP1	chr1	201454504	-	MGQRARLGSRPRRRRNDPRAVPGLRPLPPLPGTAATEPARDPEVLPRHQVLPQPHLSLLPHGRRRGRARPCRRCRRNRAAGGPGIRPAFD VPSVAKALSQPPWQTRMARFTAKDVMLKTSGPRALVLGKELGPWSTLSEATITHHTLPTPALFIAIPFPAALETSRIISLSALPHITNDL	193

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

DSTYK_pLDDT.png

CSRP1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
DSTYK
CSRP1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to DSTYK-CSRP1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to DSTYK-CSRP1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source