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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:KDM4A-MPL

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: KDM4A-MPL
FusionPDB ID: 41783
FusionGDB2.0 ID: 41783
HgeneTgene
Gene symbol

KDM4A

MPL

Gene ID

9682

4352

Gene namelysine demethylase 4AMPL proto-oncogene, thrombopoietin receptor
SynonymsJHDM3A|JMJD2|JMJD2A|TDRD14AC-MPL|CD110|MPLV|THCYT2|THPOR|TPOR
Cytomap

1p34.2-p34.1

1p34.2

Type of geneprotein-codingprotein-coding
Descriptionlysine-specific demethylase 4AjmjC domain-containing histone demethylation protein 3Ajumonji C domain-containing histone demethylase 3Ajumonji domain containing 2jumonji domain containing 2Ajumonji domain-containing protein 2Alysine (K)-specific demthrombopoietin receptorTPO-Rmyeloproliferative leukemia proteinmyeloproliferative leukemia virus oncogeneproto-oncogene c-Mpl
Modification date2020031320200313
UniProtAcc

O75164

Q8TAP9

Ensembl transtripts involved in fusion geneENST idsENST00000372396, ENST00000463151, 
ENST00000372470, ENST00000413998, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 11 X 10=14301 X 6 X 1=6
# samples 152
** MAII scorelog2(15/1430*10)=-3.25298074116987
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/6*10)=1.73696559416621
Context (manual curation of fusion genes in FusionPDB)

PubMed: KDM4A [Title/Abstract] AND MPL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KDM4A(44169783)-MPL(43805635), # samples:3
Anticipated loss of major functional domain due to fusion event.KDM4A-MPL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM4A-MPL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM4A-MPL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM4A-MPL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KDM4A-MPL seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF.
KDM4A-MPL seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
KDM4A-MPL seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
KDM4A-MPL seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
KDM4A-MPL seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneKDM4A

GO:0016577

histone demethylation

16024779

HgeneKDM4A

GO:0045892

negative regulation of transcription, DNA-templated

16024779

HgeneKDM4A

GO:0070544

histone H3-K36 demethylation

21914792


check buttonFusion gene breakpoints across KDM4A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MPL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ESCATCGA-2H-A9GJ-01AKDM4Achr1

44169783

-MPLchr1

43805635

+
ChimerDB4ESCATCGA-2H-A9GJ-01AKDM4Achr1

44169783

+MPLchr1

43805635

+
ChimerDB4ESCATCGA-2H-A9GJKDM4Achr1

44134970

+MPLchr1

43803769

+
ChimerDB4ESCATCGA-2H-A9GJKDM4Achr1

44137546

+MPLchr1

43803769

+
ChimerDB4ESCATCGA-2H-A9GJKDM4Achr1

44137546

+MPLchr1

43803770

+
ChimerDB4ESCATCGA-2H-A9GJKDM4Achr1

44137546

+MPLchr1

43803791

+
ChimerDB4ESCATCGA-2H-A9GJKDM4Achr1

44169783

+MPLchr1

43804942

+
ChimerDB4ESCATCGA-2H-A9GJKDM4Achr1

44169783

+MPLchr1

43805634

+
ChimerDB4ESCATCGA-2H-A9GJKDM4Achr1

44169783

+MPLchr1

43805635

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000372396KDM4Achr144169783+ENST00000372470MPLchr143805635+4406318813444051424
ENST00000372396KDM4Achr144169783+ENST00000413998MPLchr143805635+4241318813441471337
ENST00000372396KDM4Achr144169783+ENST00000372470MPLchr143805634+4406318813444051424
ENST00000372396KDM4Achr144169783+ENST00000413998MPLchr143805634+4241318813441471337
ENST00000372396KDM4Achr144134970+ENST00000372470MPLchr143803769+3326149713433251064
ENST00000372396KDM4Achr144134970+ENST00000413998MPLchr143803769+316114971343067977

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000372396ENST00000372470KDM4Achr144169783+MPLchr143805635+0.0013894820.9986105
ENST00000372396ENST00000413998KDM4Achr144169783+MPLchr143805635+0.0015844420.9984156
ENST00000372396ENST00000372470KDM4Achr144169783+MPLchr143805634+0.0013894820.9986105
ENST00000372396ENST00000413998KDM4Achr144169783+MPLchr143805634+0.0015844420.9984156
ENST00000372396ENST00000372470KDM4Achr144134970+MPLchr143803769+0.0014762840.9985238
ENST00000372396ENST00000413998KDM4Achr144134970+MPLchr143803769+0.0010717870.99892825

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>41783_41783_1_KDM4A-MPL_KDM4A_chr1_44134970_ENST00000372396_MPL_chr1_43803769_ENST00000372470_length(amino acids)=1064AA_BP=429
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKK
AMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGM
WKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMIT
FPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELP
PRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQVEDG
LTFPDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVK
NVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHS
ASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCF
TLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSP
FWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQG
PWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEE

--------------------------------------------------------------

>41783_41783_2_KDM4A-MPL_KDM4A_chr1_44134970_ENST00000372396_MPL_chr1_43803769_ENST00000413998_length(amino acids)=977AA_BP=429
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKK
AMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGM
WKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMIT
FPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELP
PRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQVEDG
LTFPDVSLLASDSEPLKCFSRTFEDLTCFWDEEEAAPSGTYQLLYAYPREKPRACPLSSQSMPHFGTRYVCQFPDQEEVRLFFPLHLWVK
NVFLNQTRTQRVLFVDSVGLPAPPSIIKAMGGSQPGELQISWEEPAPEISDFLRYELRYGPRDPKNSTGPTVIQLIATETCCPALQRPHS
ASALDQSPCAQPTMPWQDGPKQTSPSREASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCF
TLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSP
FWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQG

--------------------------------------------------------------

>41783_41783_3_KDM4A-MPL_KDM4A_chr1_44169783_ENST00000372396_MPL_chr1_43805634_ENST00000372470_length(amino acids)=1424AA_BP=1018
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKK
AMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGM
WKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMIT
FPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELP
PRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQVEDG
LTFPDYSDSTEVKFEELKNVKLEEEDEEEEQAAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSGSSRDSISSDSETSEPLSCRAQGQTG
VLTVHSYAKGDGRVTVGEPCTRKKGSAARSFSERELAEVADEYMFSLEENKKSKGRRQPLSKLPRHHPLVLQECVSDDETSEQLTPEEEA
EETEAWAKPLSQLWQNRPPNFEAEKEFNETMAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCSTDI
NLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNI
AERSPVDVSKIPLPRFKLKCIFCKKRRKRTAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALQSIT
AGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEF
EDGSQLVVKRDDVYTLDEELPKRVKSRLASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCF
TLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSP
FWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQG
PWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEE

--------------------------------------------------------------

>41783_41783_4_KDM4A-MPL_KDM4A_chr1_44169783_ENST00000372396_MPL_chr1_43805634_ENST00000413998_length(amino acids)=1337AA_BP=1018
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKK
AMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGM
WKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMIT
FPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELP
PRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQVEDG
LTFPDYSDSTEVKFEELKNVKLEEEDEEEEQAAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSGSSRDSISSDSETSEPLSCRAQGQTG
VLTVHSYAKGDGRVTVGEPCTRKKGSAARSFSERELAEVADEYMFSLEENKKSKGRRQPLSKLPRHHPLVLQECVSDDETSEQLTPEEEA
EETEAWAKPLSQLWQNRPPNFEAEKEFNETMAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCSTDI
NLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNI
AERSPVDVSKIPLPRFKLKCIFCKKRRKRTAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALQSIT
AGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEF
EDGSQLVVKRDDVYTLDEELPKRVKSRLASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCF
TLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSP
FWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQG

--------------------------------------------------------------

>41783_41783_5_KDM4A-MPL_KDM4A_chr1_44169783_ENST00000372396_MPL_chr1_43805635_ENST00000372470_length(amino acids)=1424AA_BP=1018
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKK
AMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGM
WKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMIT
FPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELP
PRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQVEDG
LTFPDYSDSTEVKFEELKNVKLEEEDEEEEQAAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSGSSRDSISSDSETSEPLSCRAQGQTG
VLTVHSYAKGDGRVTVGEPCTRKKGSAARSFSERELAEVADEYMFSLEENKKSKGRRQPLSKLPRHHPLVLQECVSDDETSEQLTPEEEA
EETEAWAKPLSQLWQNRPPNFEAEKEFNETMAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCSTDI
NLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNI
AERSPVDVSKIPLPRFKLKCIFCKKRRKRTAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALQSIT
AGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEF
EDGSQLVVKRDDVYTLDEELPKRVKSRLASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCF
TLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSP
FWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQG
PWSSWSDPTRVETATETAWISLVTALHLVLGLSAVLGLLLLRWQFPAHYRRLRHALWPSLPDLHRVLGQYLRDTAALSPPKATVSDTCEE

--------------------------------------------------------------

>41783_41783_6_KDM4A-MPL_KDM4A_chr1_44169783_ENST00000372396_MPL_chr1_43805635_ENST00000413998_length(amino acids)=1337AA_BP=1018
MASESETLNPSARIMTFYPTMEEFRNFSRYIAYIESQGAHRAGLAKVVPPKEWKPRASYDDIDDLVIPAPIQQLVTGQSGLFTQYNIQKK
AMTVREFRKIANSDKYCTPRYSEFEELERKYWKNLTFNPPIYGADVNGTLYEKHVDEWNIGRLRTILDLVEKESGITIEGVNTPYLYFGM
WKTSFAWHTEDMDLYSINYLHFGEPKSWYSVPPEHGKRLERLAKGFFPGSAQSCEAFLRHKMTLISPLMLKKYGIPFDKVTQEAGEFMIT
FPYGYHAGFNHGFNCAESTNFATRRWIEYGKQAVLCSCRKDMVKISMDVFVRKFQPERYKLWKAGKDNTVIDHTLPTPEAAEFLKESELP
PRAGNEEECPEEDMEGVEDGEEGDLKTSLAKHRIGTKRHRVCLEIPQEVSQSELFPKEDLSSEQYEMTECPAALAPVRPTHSSVRQVEDG
LTFPDYSDSTEVKFEELKNVKLEEEDEEEEQAAAALDLSVNPASVGGRLVFSGSKKKSSSSLGSGSSRDSISSDSETSEPLSCRAQGQTG
VLTVHSYAKGDGRVTVGEPCTRKKGSAARSFSERELAEVADEYMFSLEENKKSKGRRQPLSKLPRHHPLVLQECVSDDETSEQLTPEEEA
EETEAWAKPLSQLWQNRPPNFEAEKEFNETMAQQAPHCAVCMIFQTYHQVEFGGFNQNCGNASDLAPQKQRTKPLIPEMCFTSTGCSTDI
NLSTPYLEEDGTSILVSCKKCSVRVHASCYGVPPAKASEDWMCSRCSANALEEDCCLCSLRGGALQRANDDRWVHVSCAVAILEARFVNI
AERSPVDVSKIPLPRFKLKCIFCKKRRKRTAGCCVQCSHGRCPTAFHVSCAQAAGVMMQPDDWPFVVFITCFRHKIPNLERAKGALQSIT
AGQKVISKHKNGRFYQCEVVRLTTETFYEVNFDDGSFSDNLYPEDIVSQDCLQFGPPAEGEVVQVRWTDGQVYGAKFVASHPIQMYQVEF
EDGSQLVVKRDDVYTLDEELPKRVKSRLASALTAEGGSCLISGLQPGNSYWLQLRSEPDGISLGGSWGSWSLPVTVDLPGDAVALGLQCF
TLDLKNVTCQWQQQDHASSQGFFYHSRARCCPRDRYPIWENCEEEEKTNPGLQTPQFSRCHFKSRNDSIIHILVEVTTAPGTVHSYLGSP
FWIHQAVRLPTPNLHWREISSGHLELEWQHPSSWAAQETCYQLRYTGEGHQDWKVLEPPLGARGGTLELRPRSRYRLQLRARLNGPTYQG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:44169783/chr1:43805635)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
KDM4A

O75164

MPL

Q8TAP9

FUNCTION: Histone demethylase that specifically demethylates 'Lys-9' and 'Lys-36' residues of histone H3, thereby playing a central role in histone code (PubMed:26741168). Does not demethylate histone H3 'Lys-4', H3 'Lys-27' nor H4 'Lys-20'. Demethylates trimethylated H3 'Lys-9' and H3 'Lys-36' residue, while it has no activity on mono- and dimethylated residues. Demethylation of Lys residue generates formaldehyde and succinate. Participates in transcriptional repression of ASCL2 and E2F-responsive promoters via the recruitment of histone deacetylases and NCOR1, respectively. {ECO:0000269|PubMed:16024779, ECO:0000269|PubMed:16603238, ECO:0000269|PubMed:26741168}.; FUNCTION: [Isoform 2]: Crucial for muscle differentiation, promotes transcriptional activation of the Myog gene by directing the removal of repressive chromatin marks at its promoter. Lacks the N-terminal demethylase domain. {ECO:0000269|PubMed:21694756}.FUNCTION: May play a role in maintenance of cell cycle integrity by regulating mitosis or cytokinesis. {ECO:0000269|PubMed:17310276}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM4Achr1:44134970chr1:43803769ENST00000372396+1022142_308454.33333333333331065.0DomainJmjC
HgeneKDM4Achr1:44134970chr1:43803769ENST00000372396+102214_56454.33333333333331065.0DomainJmjN
HgeneKDM4Achr1:44169783chr1:43805634ENST00000372396+2122142_3081018.01065.0DomainJmjC
HgeneKDM4Achr1:44169783chr1:43805634ENST00000372396+212214_561018.01065.0DomainJmjN
HgeneKDM4Achr1:44169783chr1:43805634ENST00000372396+2122897_9541018.01065.0DomainNote=Tudor 1
HgeneKDM4Achr1:44169783chr1:43805634ENST00000372396+2122955_10111018.01065.0DomainNote=Tudor 2
HgeneKDM4Achr1:44169783chr1:43805635ENST00000372396+2122142_3081018.01065.0DomainJmjC
HgeneKDM4Achr1:44169783chr1:43805635ENST00000372396+212214_561018.01065.0DomainJmjN
HgeneKDM4Achr1:44169783chr1:43805635ENST00000372396+2122897_9541018.01065.0DomainNote=Tudor 1
HgeneKDM4Achr1:44169783chr1:43805635ENST00000372396+2122955_10111018.01065.0DomainNote=Tudor 2
HgeneKDM4Achr1:44169783chr1:43805634ENST00000372396+2122709_7671018.01065.0Zinc fingerNote=PHD-type 1
HgeneKDM4Achr1:44169783chr1:43805634ENST00000372396+2122772_8051018.01065.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Achr1:44169783chr1:43805634ENST00000372396+2122828_8851018.01065.0Zinc fingerPHD-type 2
HgeneKDM4Achr1:44169783chr1:43805635ENST00000372396+2122709_7671018.01065.0Zinc fingerNote=PHD-type 1
HgeneKDM4Achr1:44169783chr1:43805635ENST00000372396+2122772_8051018.01065.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Achr1:44169783chr1:43805635ENST00000372396+2122828_8851018.01065.0Zinc fingerPHD-type 2
TgeneMPLchr1:44134970chr1:43803769ENST00000372470012335_33826.333333333333332636.0Compositional biasNote=Poly-Glu
TgeneMPLchr1:44134970chr1:43803769ENST00000372470012508_51326.333333333333332636.0Compositional biasNote=Poly-Leu
TgeneMPLchr1:44169783chr1:43805634ENST00000372470312335_338230.0636.0Compositional biasNote=Poly-Glu
TgeneMPLchr1:44169783chr1:43805634ENST00000372470312508_513230.0636.0Compositional biasNote=Poly-Leu
TgeneMPLchr1:44169783chr1:43805635ENST00000372470312335_338230.0636.0Compositional biasNote=Poly-Glu
TgeneMPLchr1:44169783chr1:43805635ENST00000372470312508_513230.0636.0Compositional biasNote=Poly-Leu
TgeneMPLchr1:44134970chr1:43803769ENST00000372470012172_28126.333333333333332636.0DomainFibronectin type-III 1
TgeneMPLchr1:44134970chr1:43803769ENST00000372470012392_48626.333333333333332636.0DomainFibronectin type-III 2
TgeneMPLchr1:44169783chr1:43805634ENST00000372470312392_486230.0636.0DomainFibronectin type-III 2
TgeneMPLchr1:44169783chr1:43805635ENST00000372470312392_486230.0636.0DomainFibronectin type-III 2
TgeneMPLchr1:44134970chr1:43803769ENST00000372470012474_47826.333333333333332636.0MotifNote=WSXWS motif
TgeneMPLchr1:44134970chr1:43803769ENST00000372470012528_53626.333333333333332636.0MotifNote=Box 1 motif
TgeneMPLchr1:44169783chr1:43805634ENST00000372470312474_478230.0636.0MotifNote=WSXWS motif
TgeneMPLchr1:44169783chr1:43805634ENST00000372470312528_536230.0636.0MotifNote=Box 1 motif
TgeneMPLchr1:44169783chr1:43805635ENST00000372470312474_478230.0636.0MotifNote=WSXWS motif
TgeneMPLchr1:44169783chr1:43805635ENST00000372470312528_536230.0636.0MotifNote=Box 1 motif
TgeneMPLchr1:44134970chr1:43803769ENST0000037247001226_49126.333333333333332636.0Topological domainExtracellular
TgeneMPLchr1:44134970chr1:43803769ENST00000372470012514_63526.333333333333332636.0Topological domainCytoplasmic
TgeneMPLchr1:44169783chr1:43805634ENST00000372470312514_635230.0636.0Topological domainCytoplasmic
TgeneMPLchr1:44169783chr1:43805635ENST00000372470312514_635230.0636.0Topological domainCytoplasmic
TgeneMPLchr1:44134970chr1:43803769ENST00000372470012492_51326.333333333333332636.0TransmembraneHelical
TgeneMPLchr1:44169783chr1:43805634ENST00000372470312492_513230.0636.0TransmembraneHelical
TgeneMPLchr1:44169783chr1:43805635ENST00000372470312492_513230.0636.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneKDM4Achr1:44134970chr1:43803769ENST00000372396+1022897_954454.33333333333331065.0DomainNote=Tudor 1
HgeneKDM4Achr1:44134970chr1:43803769ENST00000372396+1022955_1011454.33333333333331065.0DomainNote=Tudor 2
HgeneKDM4Achr1:44134970chr1:43803769ENST00000372396+1022709_767454.33333333333331065.0Zinc fingerNote=PHD-type 1
HgeneKDM4Achr1:44134970chr1:43803769ENST00000372396+1022772_805454.33333333333331065.0Zinc fingerC2HC pre-PHD-type
HgeneKDM4Achr1:44134970chr1:43803769ENST00000372396+1022828_885454.33333333333331065.0Zinc fingerPHD-type 2
TgeneMPLchr1:44169783chr1:43805634ENST00000372470312172_281230.0636.0DomainFibronectin type-III 1
TgeneMPLchr1:44169783chr1:43805635ENST00000372470312172_281230.0636.0DomainFibronectin type-III 1
TgeneMPLchr1:44169783chr1:43805634ENST0000037247031226_491230.0636.0Topological domainExtracellular
TgeneMPLchr1:44169783chr1:43805635ENST0000037247031226_491230.0636.0Topological domainExtracellular


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
KDM4A_pLDDT.png
all structure
all structure
MPL_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
KDM4A
MPL


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneKDM4Achr1:44134970chr1:43803769ENST00000372396+1022597_638454.33333333333331065.0NCOR1


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Related Drugs to KDM4A-MPL


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to KDM4A-MPL


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource