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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:KLK2-ETV1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: KLK2-ETV1
	FusionPDB ID: 43053
	FusionGDB2.0 ID: 43053
		Hgene	Tgene
	Gene symbol	KLK2	ETV1
	Gene ID	3817	2115
	Gene name	kallikrein related peptidase 2	ETS variant transcription factor 1
	Synonyms	KLK2A2\|hGK-1\|hK2	ER81
	Cytomap	19q13.33	7p21.2
	Type of gene	protein-coding	protein-coding
	Description	kallikrein-2glandular kallikrein 2glandular kallikrein-1kallikrein 2, prostatictissue kallikrein-2	ETS translocation variant 1ETS variant 1ets variant gene 1ets-related protein 81
	Modification date	20200313	20200313
	UniProtAcc	P20151	P50549
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000597509, ENST00000325321, ENST00000358049, ENST00000391810,	ENST00000242066, ENST00000343495, ENST00000399357, ENST00000403527, ENST00000403685, ENST00000405192, ENST00000405218, ENST00000405358, ENST00000420159, ENST00000430479, ENST00000476720,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	21 X 19 X 4=1596	13 X 27 X 6=2106
	# samples	30	30
	** MAII score	log2(30/1596*10)=-2.41142624572647 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(30/2106*10)=-2.81147103052984 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: KLK2 [Title/Abstract] AND ETV1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	KLK2(51376775)-ETV1(13971374), # samples:3 KLK2(51378136)-ETV1(13971374), # samples:3
Anticipated loss of major functional domain due to fusion event.	KLK2-ETV1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KLK2-ETV1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. KLK2-ETV1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KLK2-ETV1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. KLK2-ETV1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. KLK2-ETV1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. KLK2-ETV1 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. KLK2-ETV1 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	ETV1	GO:0045944	positive regulation of transcription by RNA polymerase II	12750007

Fusion gene breakpoints across KLK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ETV1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	adenocarcinoma	HM245385	KLK2	chr19	51376775		ETV1	chr7	13946187
ChimerDB4	PRAD	TCGA-ZG-A9LY-01A	KLK2	chr19	51376774	+	ETV1	chr7	13950931	-
ChimerDB4	PRAD	TCGA-ZG-A9LY-01A	KLK2	chr19	51376774	+	ETV1	chr7	13971373	-
ChimerDB4	PRAD	TCGA-ZG-A9LY-01A	KLK2	chr19	51376775	-	ETV1	chr7	13971374	-
ChimerDB4	PRAD	TCGA-ZG-A9LY-01A	KLK2	chr19	51378135	+	ETV1	chr7	13971373	-
ChimerDB4	PRAD	TCGA-ZG-A9LY	KLK2	chr19	51376775	+	ETV1	chr7	13971374	-
ChimerDB4	PRAD	TCGA-ZG-A9LY	KLK2	chr19	51378136	+	ETV1	chr7	13971374	-
ChimerKB3	.	.	KLK2	chr19	51378136	+	ETV1	chr7	13975521	-
ChiTaRS5.0	N/A	HM245385	KLK2	chr19	51376775	+	ETV1	chr7	13971375	-
ChiTaRS5.0	N/A	HM245386	KLK2	chr19	51378136	+	ETV1	chr7	13971374	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000325321	KLK2	chr19	51378136	+	ENST00000430479	ETV1	chr7	13975521	-	6138	431	27	1499	490
ENST00000358049	KLK2	chr19	51378136	+	ENST00000430479	ETV1	chr7	13975521	-	5929	222	16	1290	424
ENST00000325321	KLK2	chr19	51378136	+	ENST00000430479	ETV1	chr7	13971374	-	5949	431	27	1310	427
ENST00000325321	KLK2	chr19	51378136	+	ENST00000399357	ETV1	chr7	13971374	-	5944	431	27	1310	427
ENST00000325321	KLK2	chr19	51378136	+	ENST00000420159	ETV1	chr7	13971374	-	5944	431	27	1310	427
ENST00000325321	KLK2	chr19	51378136	+	ENST00000343495	ETV1	chr7	13971374	-	5944	431	27	1310	427
ENST00000325321	KLK2	chr19	51378136	+	ENST00000242066	ETV1	chr7	13971374	-	5944	431	27	1310	427
ENST00000325321	KLK2	chr19	51378136	+	ENST00000405192	ETV1	chr7	13971374	-	4078	431	27	1241	404
ENST00000325321	KLK2	chr19	51378136	+	ENST00000405358	ETV1	chr7	13971374	-	3909	431	27	1310	427
ENST00000325321	KLK2	chr19	51378136	+	ENST00000403527	ETV1	chr7	13971374	-	3022	431	27	1310	427
ENST00000325321	KLK2	chr19	51378136	+	ENST00000405218	ETV1	chr7	13971374	-	2796	431	27	1310	427
ENST00000325321	KLK2	chr19	51378136	+	ENST00000403685	ETV1	chr7	13971374	-	1319	431	27	1310	427
ENST00000358049	KLK2	chr19	51378136	+	ENST00000430479	ETV1	chr7	13971374	-	5740	222	16	1101	361
ENST00000358049	KLK2	chr19	51378136	+	ENST00000399357	ETV1	chr7	13971374	-	5735	222	16	1101	361
ENST00000358049	KLK2	chr19	51378136	+	ENST00000420159	ETV1	chr7	13971374	-	5735	222	16	1101	361
ENST00000358049	KLK2	chr19	51378136	+	ENST00000343495	ETV1	chr7	13971374	-	5735	222	16	1101	361
ENST00000358049	KLK2	chr19	51378136	+	ENST00000242066	ETV1	chr7	13971374	-	5735	222	16	1101	361
ENST00000358049	KLK2	chr19	51378136	+	ENST00000405192	ETV1	chr7	13971374	-	3869	222	16	1032	338
ENST00000358049	KLK2	chr19	51378136	+	ENST00000405358	ETV1	chr7	13971374	-	3700	222	16	1101	361
ENST00000358049	KLK2	chr19	51378136	+	ENST00000403527	ETV1	chr7	13971374	-	2813	222	16	1101	361
ENST00000358049	KLK2	chr19	51378136	+	ENST00000405218	ETV1	chr7	13971374	-	2587	222	16	1101	361
ENST00000358049	KLK2	chr19	51378136	+	ENST00000403685	ETV1	chr7	13971374	-	1110	222	16	1101	361
ENST00000325321	KLK2	chr19	51376774	+	ENST00000430479	ETV1	chr7	13950931	-	5541	271	27	902	291
ENST00000325321	KLK2	chr19	51376774	+	ENST00000399357	ETV1	chr7	13950931	-	5536	271	27	902	291
ENST00000325321	KLK2	chr19	51376774	+	ENST00000420159	ETV1	chr7	13950931	-	5536	271	27	902	291
ENST00000325321	KLK2	chr19	51376774	+	ENST00000343495	ETV1	chr7	13950931	-	5536	271	27	902	291
ENST00000325321	KLK2	chr19	51376774	+	ENST00000242066	ETV1	chr7	13950931	-	5536	271	27	902	291
ENST00000358049	KLK2	chr19	51376774	+	ENST00000430479	ETV1	chr7	13950931	-	5332	62	16	693	225
ENST00000358049	KLK2	chr19	51376774	+	ENST00000399357	ETV1	chr7	13950931	-	5327	62	16	693	225
ENST00000358049	KLK2	chr19	51376774	+	ENST00000420159	ETV1	chr7	13950931	-	5327	62	16	693	225
ENST00000358049	KLK2	chr19	51376774	+	ENST00000343495	ETV1	chr7	13950931	-	5327	62	16	693	225
ENST00000358049	KLK2	chr19	51376774	+	ENST00000242066	ETV1	chr7	13950931	-	5327	62	16	693	225
ENST00000325321	KLK2	chr19	51378135	+	ENST00000430479	ETV1	chr7	13971373	-	5949	431	27	1310	427
ENST00000325321	KLK2	chr19	51378135	+	ENST00000399357	ETV1	chr7	13971373	-	5944	431	27	1310	427
ENST00000325321	KLK2	chr19	51378135	+	ENST00000420159	ETV1	chr7	13971373	-	5944	431	27	1310	427
ENST00000325321	KLK2	chr19	51378135	+	ENST00000343495	ETV1	chr7	13971373	-	5944	431	27	1310	427
ENST00000325321	KLK2	chr19	51378135	+	ENST00000242066	ETV1	chr7	13971373	-	5944	431	27	1310	427
ENST00000325321	KLK2	chr19	51378135	+	ENST00000405192	ETV1	chr7	13971373	-	4078	431	27	1241	404
ENST00000325321	KLK2	chr19	51378135	+	ENST00000405358	ETV1	chr7	13971373	-	3909	431	27	1310	427
ENST00000325321	KLK2	chr19	51378135	+	ENST00000403527	ETV1	chr7	13971373	-	3022	431	27	1310	427
ENST00000325321	KLK2	chr19	51378135	+	ENST00000405218	ETV1	chr7	13971373	-	2796	431	27	1310	427
ENST00000325321	KLK2	chr19	51378135	+	ENST00000403685	ETV1	chr7	13971373	-	1319	431	27	1310	427
ENST00000358049	KLK2	chr19	51378135	+	ENST00000430479	ETV1	chr7	13971373	-	5740	222	16	1101	361
ENST00000358049	KLK2	chr19	51378135	+	ENST00000399357	ETV1	chr7	13971373	-	5735	222	16	1101	361
ENST00000358049	KLK2	chr19	51378135	+	ENST00000420159	ETV1	chr7	13971373	-	5735	222	16	1101	361
ENST00000358049	KLK2	chr19	51378135	+	ENST00000343495	ETV1	chr7	13971373	-	5735	222	16	1101	361
ENST00000358049	KLK2	chr19	51378135	+	ENST00000242066	ETV1	chr7	13971373	-	5735	222	16	1101	361
ENST00000358049	KLK2	chr19	51378135	+	ENST00000405192	ETV1	chr7	13971373	-	3869	222	16	1032	338
ENST00000358049	KLK2	chr19	51378135	+	ENST00000405358	ETV1	chr7	13971373	-	3700	222	16	1101	361
ENST00000358049	KLK2	chr19	51378135	+	ENST00000403527	ETV1	chr7	13971373	-	2813	222	16	1101	361
ENST00000358049	KLK2	chr19	51378135	+	ENST00000405218	ETV1	chr7	13971373	-	2587	222	16	1101	361
ENST00000358049	KLK2	chr19	51378135	+	ENST00000403685	ETV1	chr7	13971373	-	1110	222	16	1101	361
ENST00000325321	KLK2	chr19	51376775		ENST00000430479	ETV1	chr7	13946187		5366	271	2276	2563	95
ENST00000325321	KLK2	chr19	51376775		ENST00000399357	ETV1	chr7	13946187		5361	271	2276	2563	95
ENST00000325321	KLK2	chr19	51376775		ENST00000420159	ETV1	chr7	13946187		5361	271	2276	2563	95
ENST00000325321	KLK2	chr19	51376775		ENST00000343495	ETV1	chr7	13946187		5361	271	2276	2563	95
ENST00000325321	KLK2	chr19	51376775		ENST00000242066	ETV1	chr7	13946187		5361	271	2276	2563	95
ENST00000325321	KLK2	chr19	51376775		ENST00000405192	ETV1	chr7	13946187		3564	271	2276	2563	95
ENST00000325321	KLK2	chr19	51376775		ENST00000405358	ETV1	chr7	13946187		3326	271	2276	2563	95
ENST00000325321	KLK2	chr19	51376775		ENST00000403527	ETV1	chr7	13946187		2439	271	504	220	94
ENST00000325321	KLK2	chr19	51376775		ENST00000405218	ETV1	chr7	13946187		2213	271	504	220	94
ENST00000325321	KLK2	chr19	51376775		ENST00000403685	ETV1	chr7	13946187		736	271	537	220	105
ENST00000358049	KLK2	chr19	51376775		ENST00000430479	ETV1	chr7	13946187		5157	62	2067	2354	95
ENST00000358049	KLK2	chr19	51376775		ENST00000399357	ETV1	chr7	13946187		5152	62	2067	2354	95
ENST00000358049	KLK2	chr19	51376775		ENST00000420159	ETV1	chr7	13946187		5152	62	2067	2354	95
ENST00000358049	KLK2	chr19	51376775		ENST00000343495	ETV1	chr7	13946187		5152	62	2067	2354	95
ENST00000358049	KLK2	chr19	51376775		ENST00000242066	ETV1	chr7	13946187		5152	62	2067	2354	95
ENST00000358049	KLK2	chr19	51376775		ENST00000405192	ETV1	chr7	13946187		3355	62	2067	2354	95
ENST00000358049	KLK2	chr19	51376775		ENST00000405358	ETV1	chr7	13946187		3117	62	2067	2354	95
ENST00000358049	KLK2	chr19	51376775		ENST00000403527	ETV1	chr7	13946187		2230	62	1911	2159	82
ENST00000358049	KLK2	chr19	51376775		ENST00000405218	ETV1	chr7	13946187		2004	62	295	11	94
ENST00000358049	KLK2	chr19	51376775		ENST00000403685	ETV1	chr7	13946187		527	62	328	11	105

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000325321	ENST00000430479	KLK2	chr19	51378136	+	ETV1	chr7	13971374	-	0.000365328	0.9996346
ENST00000325321	ENST00000399357	KLK2	chr19	51378136	+	ETV1	chr7	13971374	-	0.00036515	0.99963486
ENST00000325321	ENST00000420159	KLK2	chr19	51378136	+	ETV1	chr7	13971374	-	0.00036515	0.99963486
ENST00000325321	ENST00000343495	KLK2	chr19	51378136	+	ETV1	chr7	13971374	-	0.00036515	0.99963486
ENST00000325321	ENST00000242066	KLK2	chr19	51378136	+	ETV1	chr7	13971374	-	0.00036515	0.99963486
ENST00000325321	ENST00000405192	KLK2	chr19	51378136	+	ETV1	chr7	13971374	-	0.000206413	0.9997936
ENST00000325321	ENST00000405358	KLK2	chr19	51378136	+	ETV1	chr7	13971374	-	0.00039008	0.9996099
ENST00000325321	ENST00000403527	KLK2	chr19	51378136	+	ETV1	chr7	13971374	-	0.000570883	0.99942905
ENST00000325321	ENST00000405218	KLK2	chr19	51378136	+	ETV1	chr7	13971374	-	0.000558339	0.9994417
ENST00000325321	ENST00000403685	KLK2	chr19	51378136	+	ETV1	chr7	13971374	-	0.008032127	0.99196786
ENST00000358049	ENST00000430479	KLK2	chr19	51378136	+	ETV1	chr7	13971374	-	0.000356367	0.9996437
ENST00000358049	ENST00000399357	KLK2	chr19	51378136	+	ETV1	chr7	13971374	-	0.000356324	0.9996437
ENST00000358049	ENST00000420159	KLK2	chr19	51378136	+	ETV1	chr7	13971374	-	0.000356324	0.9996437
ENST00000358049	ENST00000343495	KLK2	chr19	51378136	+	ETV1	chr7	13971374	-	0.000356324	0.9996437
ENST00000358049	ENST00000242066	KLK2	chr19	51378136	+	ETV1	chr7	13971374	-	0.000356324	0.9996437
ENST00000358049	ENST00000405192	KLK2	chr19	51378136	+	ETV1	chr7	13971374	-	0.000184411	0.99981564
ENST00000358049	ENST00000405358	KLK2	chr19	51378136	+	ETV1	chr7	13971374	-	0.00035507	0.9996449
ENST00000358049	ENST00000403527	KLK2	chr19	51378136	+	ETV1	chr7	13971374	-	0.000481195	0.9995189
ENST00000358049	ENST00000405218	KLK2	chr19	51378136	+	ETV1	chr7	13971374	-	0.000480777	0.9995192
ENST00000358049	ENST00000403685	KLK2	chr19	51378136	+	ETV1	chr7	13971374	-	0.005189038	0.99481094
ENST00000325321	ENST00000430479	KLK2	chr19	51376774	+	ETV1	chr7	13950931	-	0.00031559	0.99968445
ENST00000325321	ENST00000399357	KLK2	chr19	51376774	+	ETV1	chr7	13950931	-	0.0003225	0.99967754
ENST00000325321	ENST00000420159	KLK2	chr19	51376774	+	ETV1	chr7	13950931	-	0.0003225	0.99967754
ENST00000325321	ENST00000343495	KLK2	chr19	51376774	+	ETV1	chr7	13950931	-	0.0003225	0.99967754
ENST00000325321	ENST00000242066	KLK2	chr19	51376774	+	ETV1	chr7	13950931	-	0.0003225	0.99967754
ENST00000358049	ENST00000430479	KLK2	chr19	51376774	+	ETV1	chr7	13950931	-	0.000298699	0.9997013
ENST00000358049	ENST00000399357	KLK2	chr19	51376774	+	ETV1	chr7	13950931	-	0.000304978	0.99969506
ENST00000358049	ENST00000420159	KLK2	chr19	51376774	+	ETV1	chr7	13950931	-	0.000304978	0.99969506
ENST00000358049	ENST00000343495	KLK2	chr19	51376774	+	ETV1	chr7	13950931	-	0.000304978	0.99969506
ENST00000358049	ENST00000242066	KLK2	chr19	51376774	+	ETV1	chr7	13950931	-	0.000304978	0.99969506
ENST00000325321	ENST00000430479	KLK2	chr19	51378135	+	ETV1	chr7	13971373	-	0.000365328	0.9996346
ENST00000325321	ENST00000399357	KLK2	chr19	51378135	+	ETV1	chr7	13971373	-	0.00036515	0.99963486
ENST00000325321	ENST00000420159	KLK2	chr19	51378135	+	ETV1	chr7	13971373	-	0.00036515	0.99963486
ENST00000325321	ENST00000343495	KLK2	chr19	51378135	+	ETV1	chr7	13971373	-	0.00036515	0.99963486
ENST00000325321	ENST00000242066	KLK2	chr19	51378135	+	ETV1	chr7	13971373	-	0.00036515	0.99963486
ENST00000325321	ENST00000405192	KLK2	chr19	51378135	+	ETV1	chr7	13971373	-	0.000206413	0.9997936
ENST00000325321	ENST00000405358	KLK2	chr19	51378135	+	ETV1	chr7	13971373	-	0.00039008	0.9996099
ENST00000325321	ENST00000403527	KLK2	chr19	51378135	+	ETV1	chr7	13971373	-	0.000570883	0.99942905
ENST00000325321	ENST00000405218	KLK2	chr19	51378135	+	ETV1	chr7	13971373	-	0.000558339	0.9994417
ENST00000325321	ENST00000403685	KLK2	chr19	51378135	+	ETV1	chr7	13971373	-	0.008032127	0.99196786
ENST00000358049	ENST00000430479	KLK2	chr19	51378135	+	ETV1	chr7	13971373	-	0.000356367	0.9996437
ENST00000358049	ENST00000399357	KLK2	chr19	51378135	+	ETV1	chr7	13971373	-	0.000356324	0.9996437
ENST00000358049	ENST00000420159	KLK2	chr19	51378135	+	ETV1	chr7	13971373	-	0.000356324	0.9996437
ENST00000358049	ENST00000343495	KLK2	chr19	51378135	+	ETV1	chr7	13971373	-	0.000356324	0.9996437
ENST00000358049	ENST00000242066	KLK2	chr19	51378135	+	ETV1	chr7	13971373	-	0.000356324	0.9996437
ENST00000358049	ENST00000405192	KLK2	chr19	51378135	+	ETV1	chr7	13971373	-	0.000184411	0.99981564
ENST00000358049	ENST00000405358	KLK2	chr19	51378135	+	ETV1	chr7	13971373	-	0.00035507	0.9996449
ENST00000358049	ENST00000403527	KLK2	chr19	51378135	+	ETV1	chr7	13971373	-	0.000481195	0.9995189
ENST00000358049	ENST00000405218	KLK2	chr19	51378135	+	ETV1	chr7	13971373	-	0.000480777	0.9995192
ENST00000358049	ENST00000403685	KLK2	chr19	51378135	+	ETV1	chr7	13971373	-	0.005189038	0.99481094
ENST00000325321	ENST00000430479	KLK2	chr19	51376775		ETV1	chr7	13946187		0.40662763	0.5933724
ENST00000325321	ENST00000399357	KLK2	chr19	51376775		ETV1	chr7	13946187		0.5040806	0.49591944
ENST00000325321	ENST00000420159	KLK2	chr19	51376775		ETV1	chr7	13946187		0.5040806	0.49591944
ENST00000325321	ENST00000343495	KLK2	chr19	51376775		ETV1	chr7	13946187		0.5040806	0.49591944
ENST00000325321	ENST00000242066	KLK2	chr19	51376775		ETV1	chr7	13946187		0.5040806	0.49591944
ENST00000325321	ENST00000405192	KLK2	chr19	51376775		ETV1	chr7	13946187		0.4302016	0.56979847
ENST00000325321	ENST00000405358	KLK2	chr19	51376775		ETV1	chr7	13946187		0.56498826	0.43501177
ENST00000325321	ENST00000403527	KLK2	chr19	51376775		ETV1	chr7	13946187		0.7782925	0.22170758
ENST00000325321	ENST00000405218	KLK2	chr19	51376775		ETV1	chr7	13946187		0.88065296	0.11934702
ENST00000325321	ENST00000403685	KLK2	chr19	51376775		ETV1	chr7	13946187		0.13477693	0.8652231
ENST00000358049	ENST00000430479	KLK2	chr19	51376775		ETV1	chr7	13946187		0.39166245	0.6083376
ENST00000358049	ENST00000399357	KLK2	chr19	51376775		ETV1	chr7	13946187		0.48803467	0.51196533
ENST00000358049	ENST00000420159	KLK2	chr19	51376775		ETV1	chr7	13946187		0.48803467	0.51196533
ENST00000358049	ENST00000343495	KLK2	chr19	51376775		ETV1	chr7	13946187		0.48803467	0.51196533
ENST00000358049	ENST00000242066	KLK2	chr19	51376775		ETV1	chr7	13946187		0.48803467	0.51196533
ENST00000358049	ENST00000405192	KLK2	chr19	51376775		ETV1	chr7	13946187		0.40111807	0.5988819
ENST00000358049	ENST00000405358	KLK2	chr19	51376775		ETV1	chr7	13946187		0.53209186	0.46790814
ENST00000358049	ENST00000403527	KLK2	chr19	51376775		ETV1	chr7	13946187		0.7275242	0.2724758
ENST00000358049	ENST00000405218	KLK2	chr19	51376775		ETV1	chr7	13946187		0.8760122	0.12398781
ENST00000358049	ENST00000403685	KLK2	chr19	51376775		ETV1	chr7	13946187		0.12619677	0.87380326

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>43053_43053_1_KLK2-ETV1_KLK2_chr19_51376774_ENST00000325321_ETV1_chr7_13950931_ENST00000242066_length(amino acids)=291AA_BP=81
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTEVPSCHSIY
MRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLI
EPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDES

--------------------------------------------------------------

>43053_43053_2_KLK2-ETV1_KLK2_chr19_51376774_ENST00000325321_ETV1_chr7_13950931_ENST00000343495_length(amino acids)=291AA_BP=81
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTEVPSCHSIY
MRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLI
EPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDES

--------------------------------------------------------------

>43053_43053_3_KLK2-ETV1_KLK2_chr19_51376774_ENST00000325321_ETV1_chr7_13950931_ENST00000399357_length(amino acids)=291AA_BP=81
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTEVPSCHSIY
MRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLI
EPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDES

--------------------------------------------------------------

>43053_43053_4_KLK2-ETV1_KLK2_chr19_51376774_ENST00000325321_ETV1_chr7_13950931_ENST00000420159_length(amino acids)=291AA_BP=81
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTEVPSCHSIY
MRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLI
EPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDES

--------------------------------------------------------------

>43053_43053_5_KLK2-ETV1_KLK2_chr19_51376774_ENST00000325321_ETV1_chr7_13950931_ENST00000430479_length(amino acids)=291AA_BP=81
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTEVPSCHSIY
MRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLI
EPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDES

--------------------------------------------------------------

>43053_43053_6_KLK2-ETV1_KLK2_chr19_51376774_ENST00000358049_ETV1_chr7_13950931_ENST00000242066_length(amino acids)=225AA_BP=15
MWDLVLSIALSVGCTEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLV
ALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRP

--------------------------------------------------------------

>43053_43053_7_KLK2-ETV1_KLK2_chr19_51376774_ENST00000358049_ETV1_chr7_13950931_ENST00000343495_length(amino acids)=225AA_BP=15
MWDLVLSIALSVGCTEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLV
ALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRP

--------------------------------------------------------------

>43053_43053_8_KLK2-ETV1_KLK2_chr19_51376774_ENST00000358049_ETV1_chr7_13950931_ENST00000399357_length(amino acids)=225AA_BP=15
MWDLVLSIALSVGCTEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLV
ALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRP

--------------------------------------------------------------

>43053_43053_9_KLK2-ETV1_KLK2_chr19_51376774_ENST00000358049_ETV1_chr7_13950931_ENST00000420159_length(amino acids)=225AA_BP=15
MWDLVLSIALSVGCTEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLV
ALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRP

--------------------------------------------------------------

>43053_43053_10_KLK2-ETV1_KLK2_chr19_51376774_ENST00000358049_ETV1_chr7_13950931_ENST00000430479_length(amino acids)=225AA_BP=15
MWDLVLSIALSVGCTEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLV
ALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRP

--------------------------------------------------------------

>43053_43053_11_KLK2-ETV1_KLK2_chr19_51376775_ENST00000325321_ETV1_chr7_13946187_ENST00000242066_length(amino acids)=95AA_BP=
MIPPATHFPKLHRSQLISLSGAVIKKPKHQNCYSSHLILQKVLQFQNMYVTCDFNDCCSYTSCIILAHFGPKKENYALKIRTFSPHYAYV

--------------------------------------------------------------

>43053_43053_12_KLK2-ETV1_KLK2_chr19_51376775_ENST00000325321_ETV1_chr7_13946187_ENST00000343495_length(amino acids)=95AA_BP=
MIPPATHFPKLHRSQLISLSGAVIKKPKHQNCYSSHLILQKVLQFQNMYVTCDFNDCCSYTSCIILAHFGPKKENYALKIRTFSPHYAYV

--------------------------------------------------------------

>43053_43053_13_KLK2-ETV1_KLK2_chr19_51376775_ENST00000325321_ETV1_chr7_13946187_ENST00000399357_length(amino acids)=95AA_BP=
MIPPATHFPKLHRSQLISLSGAVIKKPKHQNCYSSHLILQKVLQFQNMYVTCDFNDCCSYTSCIILAHFGPKKENYALKIRTFSPHYAYV

--------------------------------------------------------------

>43053_43053_14_KLK2-ETV1_KLK2_chr19_51376775_ENST00000325321_ETV1_chr7_13946187_ENST00000403527_length(amino acids)=94AA_BP=
MSLVLIHVAFVVGVGVAAAPFRHVGHALIKVRKRHCVLLVDVTFHVCLQQWTLIIWKGHGEKGFWITHKLVDISLSSHQCTPQTRRWREP

--------------------------------------------------------------

>43053_43053_15_KLK2-ETV1_KLK2_chr19_51376775_ENST00000325321_ETV1_chr7_13946187_ENST00000403685_length(amino acids)=105AA_BP=
MACFSECPNVGPPLVLIHVAFVVGVGVAAAPFRHVGHALIKVRKRHCVLLVDVTFHVCLQQWTLIIWKGHGEKGFWITHKLVDISLSSHQ

--------------------------------------------------------------

>43053_43053_16_KLK2-ETV1_KLK2_chr19_51376775_ENST00000325321_ETV1_chr7_13946187_ENST00000405192_length(amino acids)=95AA_BP=
MIPPATHFPKLHRSQLISLSGAVIKKPKHQNCYSSHLILQKVLQFQNMYVTCDFNDCCSYTSCIILAHFGPKKENYALKIRTFSPHYAYV

--------------------------------------------------------------

>43053_43053_17_KLK2-ETV1_KLK2_chr19_51376775_ENST00000325321_ETV1_chr7_13946187_ENST00000405218_length(amino acids)=94AA_BP=
MSLVLIHVAFVVGVGVAAAPFRHVGHALIKVRKRHCVLLVDVTFHVCLQQWTLIIWKGHGEKGFWITHKLVDISLSSHQCTPQTRRWREP

--------------------------------------------------------------

>43053_43053_18_KLK2-ETV1_KLK2_chr19_51376775_ENST00000325321_ETV1_chr7_13946187_ENST00000405358_length(amino acids)=95AA_BP=
MIPPATHFPKLHRSQLISLSGAVIKKPKHQNCYSSHLILQKVLQFQNMYVTCDFNDCCSYTSCIILAHFGPKKENYALKIRTFSPHYAYV

--------------------------------------------------------------

>43053_43053_19_KLK2-ETV1_KLK2_chr19_51376775_ENST00000325321_ETV1_chr7_13946187_ENST00000420159_length(amino acids)=95AA_BP=
MIPPATHFPKLHRSQLISLSGAVIKKPKHQNCYSSHLILQKVLQFQNMYVTCDFNDCCSYTSCIILAHFGPKKENYALKIRTFSPHYAYV

--------------------------------------------------------------

>43053_43053_20_KLK2-ETV1_KLK2_chr19_51376775_ENST00000325321_ETV1_chr7_13946187_ENST00000430479_length(amino acids)=95AA_BP=
MIPPATHFPKLHRSQLISLSGAVIKKPKHQNCYSSHLILQKVLQFQNMYVTCDFNDCCSYTSCIILAHFGPKKENYALKIRTFSPHYAYV

--------------------------------------------------------------

>43053_43053_21_KLK2-ETV1_KLK2_chr19_51376775_ENST00000358049_ETV1_chr7_13946187_ENST00000242066_length(amino acids)=95AA_BP=
MIPPATHFPKLHRSQLISLSGAVIKKPKHQNCYSSHLILQKVLQFQNMYVTCDFNDCCSYTSCIILAHFGPKKENYALKIRTFSPHYAYV

--------------------------------------------------------------

>43053_43053_22_KLK2-ETV1_KLK2_chr19_51376775_ENST00000358049_ETV1_chr7_13946187_ENST00000343495_length(amino acids)=95AA_BP=
MIPPATHFPKLHRSQLISLSGAVIKKPKHQNCYSSHLILQKVLQFQNMYVTCDFNDCCSYTSCIILAHFGPKKENYALKIRTFSPHYAYV

--------------------------------------------------------------

>43053_43053_23_KLK2-ETV1_KLK2_chr19_51376775_ENST00000358049_ETV1_chr7_13946187_ENST00000399357_length(amino acids)=95AA_BP=
MIPPATHFPKLHRSQLISLSGAVIKKPKHQNCYSSHLILQKVLQFQNMYVTCDFNDCCSYTSCIILAHFGPKKENYALKIRTFSPHYAYV

--------------------------------------------------------------

>43053_43053_24_KLK2-ETV1_KLK2_chr19_51376775_ENST00000358049_ETV1_chr7_13946187_ENST00000403527_length(amino acids)=82AA_BP=62

--------------------------------------------------------------

>43053_43053_25_KLK2-ETV1_KLK2_chr19_51376775_ENST00000358049_ETV1_chr7_13946187_ENST00000403685_length(amino acids)=105AA_BP=
MACFSECPNVGPPLVLIHVAFVVGVGVAAAPFRHVGHALIKVRKRHCVLLVDVTFHVCLQQWTLIIWKGHGEKGFWITHKLVDISLSSHQ

--------------------------------------------------------------

>43053_43053_26_KLK2-ETV1_KLK2_chr19_51376775_ENST00000358049_ETV1_chr7_13946187_ENST00000405192_length(amino acids)=95AA_BP=
MIPPATHFPKLHRSQLISLSGAVIKKPKHQNCYSSHLILQKVLQFQNMYVTCDFNDCCSYTSCIILAHFGPKKENYALKIRTFSPHYAYV

--------------------------------------------------------------

>43053_43053_27_KLK2-ETV1_KLK2_chr19_51376775_ENST00000358049_ETV1_chr7_13946187_ENST00000405218_length(amino acids)=94AA_BP=
MSLVLIHVAFVVGVGVAAAPFRHVGHALIKVRKRHCVLLVDVTFHVCLQQWTLIIWKGHGEKGFWITHKLVDISLSSHQCTPQTRRWREP

--------------------------------------------------------------

>43053_43053_28_KLK2-ETV1_KLK2_chr19_51376775_ENST00000358049_ETV1_chr7_13946187_ENST00000405358_length(amino acids)=95AA_BP=
MIPPATHFPKLHRSQLISLSGAVIKKPKHQNCYSSHLILQKVLQFQNMYVTCDFNDCCSYTSCIILAHFGPKKENYALKIRTFSPHYAYV

--------------------------------------------------------------

>43053_43053_29_KLK2-ETV1_KLK2_chr19_51376775_ENST00000358049_ETV1_chr7_13946187_ENST00000420159_length(amino acids)=95AA_BP=
MIPPATHFPKLHRSQLISLSGAVIKKPKHQNCYSSHLILQKVLQFQNMYVTCDFNDCCSYTSCIILAHFGPKKENYALKIRTFSPHYAYV

--------------------------------------------------------------

>43053_43053_30_KLK2-ETV1_KLK2_chr19_51376775_ENST00000358049_ETV1_chr7_13946187_ENST00000430479_length(amino acids)=95AA_BP=
MIPPATHFPKLHRSQLISLSGAVIKKPKHQNCYSSHLILQKVLQFQNMYVTCDFNDCCSYTSCIILAHFGPKKENYALKIRTFSPHYAYV

--------------------------------------------------------------

>43053_43053_31_KLK2-ETV1_KLK2_chr19_51378135_ENST00000325321_ETV1_chr7_13971373_ENST00000242066_length(amino acids)=427AA_BP=135
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAVPLIQSR
IVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQE
YHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEP
GMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERY

--------------------------------------------------------------

>43053_43053_32_KLK2-ETV1_KLK2_chr19_51378135_ENST00000325321_ETV1_chr7_13971373_ENST00000343495_length(amino acids)=427AA_BP=135
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAVPLIQSR
IVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQE
YHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEP
GMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERY

--------------------------------------------------------------

>43053_43053_33_KLK2-ETV1_KLK2_chr19_51378135_ENST00000325321_ETV1_chr7_13971373_ENST00000399357_length(amino acids)=427AA_BP=135
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAVPLIQSR
IVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQE
YHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEP
GMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERY

--------------------------------------------------------------

>43053_43053_34_KLK2-ETV1_KLK2_chr19_51378135_ENST00000325321_ETV1_chr7_13971373_ENST00000403527_length(amino acids)=427AA_BP=135
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAVPLIQSR
IVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQE
YHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEP
GMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERY

--------------------------------------------------------------

>43053_43053_35_KLK2-ETV1_KLK2_chr19_51378135_ENST00000325321_ETV1_chr7_13971373_ENST00000403685_length(amino acids)=427AA_BP=135
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAVPLIQSR
IVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQE
YHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEP
GMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERY

--------------------------------------------------------------

>43053_43053_36_KLK2-ETV1_KLK2_chr19_51378135_ENST00000325321_ETV1_chr7_13971373_ENST00000405192_length(amino acids)=404AA_BP=135
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAVPLIQSR
IVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQE
YHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVA
LLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPL

--------------------------------------------------------------

>43053_43053_37_KLK2-ETV1_KLK2_chr19_51378135_ENST00000325321_ETV1_chr7_13971373_ENST00000405218_length(amino acids)=427AA_BP=135
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAVPLIQSR
IVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQE
YHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEP
GMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERY

--------------------------------------------------------------

>43053_43053_38_KLK2-ETV1_KLK2_chr19_51378135_ENST00000325321_ETV1_chr7_13971373_ENST00000405358_length(amino acids)=427AA_BP=135
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAVPLIQSR
IVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQE
YHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEP
GMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERY

--------------------------------------------------------------

>43053_43053_39_KLK2-ETV1_KLK2_chr19_51378135_ENST00000325321_ETV1_chr7_13971373_ENST00000420159_length(amino acids)=427AA_BP=135
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAVPLIQSR
IVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQE
YHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEP
GMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERY

--------------------------------------------------------------

>43053_43053_40_KLK2-ETV1_KLK2_chr19_51378135_ENST00000325321_ETV1_chr7_13971373_ENST00000430479_length(amino acids)=427AA_BP=135
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAVPLIQSR
IVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQE
YHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEP
GMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERY

--------------------------------------------------------------

>43053_43053_41_KLK2-ETV1_KLK2_chr19_51378135_ENST00000358049_ETV1_chr7_13971373_ENST00000242066_length(amino acids)=361AA_BP=69
MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPRE
GRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEK
GPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNY
DKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYV

--------------------------------------------------------------

>43053_43053_42_KLK2-ETV1_KLK2_chr19_51378135_ENST00000358049_ETV1_chr7_13971373_ENST00000343495_length(amino acids)=361AA_BP=69
MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPRE
GRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEK
GPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNY
DKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYV

--------------------------------------------------------------

>43053_43053_43_KLK2-ETV1_KLK2_chr19_51378135_ENST00000358049_ETV1_chr7_13971373_ENST00000399357_length(amino acids)=361AA_BP=69
MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPRE
GRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEK
GPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNY
DKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYV

--------------------------------------------------------------

>43053_43053_44_KLK2-ETV1_KLK2_chr19_51378135_ENST00000358049_ETV1_chr7_13971373_ENST00000403527_length(amino acids)=361AA_BP=69
MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPRE
GRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEK
GPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNY
DKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYV

--------------------------------------------------------------

>43053_43053_45_KLK2-ETV1_KLK2_chr19_51378135_ENST00000358049_ETV1_chr7_13971373_ENST00000403685_length(amino acids)=361AA_BP=69
MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPRE
GRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEK
GPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNY
DKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYV

--------------------------------------------------------------

>43053_43053_46_KLK2-ETV1_KLK2_chr19_51378135_ENST00000358049_ETV1_chr7_13971373_ENST00000405192_length(amino acids)=338AA_BP=69
MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPRE
GRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSGCMFEKGPRQFYDDTCVVPEKFDGDIKQE
PGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGER

--------------------------------------------------------------

>43053_43053_47_KLK2-ETV1_KLK2_chr19_51378135_ENST00000358049_ETV1_chr7_13971373_ENST00000405218_length(amino acids)=361AA_BP=69
MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPRE
GRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEK
GPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNY
DKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYV

--------------------------------------------------------------

>43053_43053_48_KLK2-ETV1_KLK2_chr19_51378135_ENST00000358049_ETV1_chr7_13971373_ENST00000405358_length(amino acids)=361AA_BP=69
MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPRE
GRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEK
GPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNY
DKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYV

--------------------------------------------------------------

>43053_43053_49_KLK2-ETV1_KLK2_chr19_51378135_ENST00000358049_ETV1_chr7_13971373_ENST00000420159_length(amino acids)=361AA_BP=69
MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPRE
GRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEK
GPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNY
DKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYV

--------------------------------------------------------------

>43053_43053_50_KLK2-ETV1_KLK2_chr19_51378135_ENST00000358049_ETV1_chr7_13971373_ENST00000430479_length(amino acids)=361AA_BP=69
MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPRE
GRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEK
GPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNY
DKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYV

--------------------------------------------------------------

>43053_43053_51_KLK2-ETV1_KLK2_chr19_51378136_ENST00000325321_ETV1_chr7_13971374_ENST00000242066_length(amino acids)=427AA_BP=135
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAVPLIQSR
IVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQE
YHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEP
GMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERY

--------------------------------------------------------------

>43053_43053_52_KLK2-ETV1_KLK2_chr19_51378136_ENST00000325321_ETV1_chr7_13971374_ENST00000343495_length(amino acids)=427AA_BP=135
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAVPLIQSR
IVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQE
YHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEP
GMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERY

--------------------------------------------------------------

>43053_43053_53_KLK2-ETV1_KLK2_chr19_51378136_ENST00000325321_ETV1_chr7_13971374_ENST00000399357_length(amino acids)=427AA_BP=135
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAVPLIQSR
IVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQE
YHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEP
GMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERY

--------------------------------------------------------------

>43053_43053_54_KLK2-ETV1_KLK2_chr19_51378136_ENST00000325321_ETV1_chr7_13971374_ENST00000403527_length(amino acids)=427AA_BP=135
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAVPLIQSR
IVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQE
YHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEP
GMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERY

--------------------------------------------------------------

>43053_43053_55_KLK2-ETV1_KLK2_chr19_51378136_ENST00000325321_ETV1_chr7_13971374_ENST00000403685_length(amino acids)=427AA_BP=135
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAVPLIQSR
IVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQE
YHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEP
GMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERY

--------------------------------------------------------------

>43053_43053_56_KLK2-ETV1_KLK2_chr19_51378136_ENST00000325321_ETV1_chr7_13971374_ENST00000405192_length(amino acids)=404AA_BP=135
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAVPLIQSR
IVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQE
YHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVA
LLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPL

--------------------------------------------------------------

>43053_43053_57_KLK2-ETV1_KLK2_chr19_51378136_ENST00000325321_ETV1_chr7_13971374_ENST00000405218_length(amino acids)=427AA_BP=135
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAVPLIQSR
IVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQE
YHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEP
GMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERY

--------------------------------------------------------------

>43053_43053_58_KLK2-ETV1_KLK2_chr19_51378136_ENST00000325321_ETV1_chr7_13971374_ENST00000405358_length(amino acids)=427AA_BP=135
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAVPLIQSR
IVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQE
YHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEP
GMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERY

--------------------------------------------------------------

>43053_43053_59_KLK2-ETV1_KLK2_chr19_51378136_ENST00000325321_ETV1_chr7_13971374_ENST00000420159_length(amino acids)=427AA_BP=135
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAVPLIQSR
IVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQE
YHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEP
GMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERY

--------------------------------------------------------------

>43053_43053_60_KLK2-ETV1_KLK2_chr19_51378136_ENST00000325321_ETV1_chr7_13971374_ENST00000430479_length(amino acids)=427AA_BP=135
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAVPLIQSR
IVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQE
YHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEP
GMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERY

--------------------------------------------------------------

>43053_43053_61_KLK2-ETV1_KLK2_chr19_51378136_ENST00000325321_ETV1_chr7_13975521_ENST00000430479_length(amino acids)=490AA_BP=135
MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLREAPQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAVPLIQSR
IVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKNAYDQKPQVGMRPSNPPTPSSTPVSPLHHASPNSTHTPKPDRAFPA
HLPPSQSIPDSSYPMDHRFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIK
QEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDD
PSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTD

--------------------------------------------------------------

>43053_43053_62_KLK2-ETV1_KLK2_chr19_51378136_ENST00000358049_ETV1_chr7_13971374_ENST00000242066_length(amino acids)=361AA_BP=69
MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPRE
GRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEK
GPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNY
DKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYV

--------------------------------------------------------------

>43053_43053_63_KLK2-ETV1_KLK2_chr19_51378136_ENST00000358049_ETV1_chr7_13971374_ENST00000343495_length(amino acids)=361AA_BP=69
MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPRE
GRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEK
GPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNY
DKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYV

--------------------------------------------------------------

>43053_43053_64_KLK2-ETV1_KLK2_chr19_51378136_ENST00000358049_ETV1_chr7_13971374_ENST00000399357_length(amino acids)=361AA_BP=69
MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPRE
GRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEK
GPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNY
DKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYV

--------------------------------------------------------------

>43053_43053_65_KLK2-ETV1_KLK2_chr19_51378136_ENST00000358049_ETV1_chr7_13971374_ENST00000403527_length(amino acids)=361AA_BP=69
MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPRE
GRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEK
GPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNY
DKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYV

--------------------------------------------------------------

>43053_43053_66_KLK2-ETV1_KLK2_chr19_51378136_ENST00000358049_ETV1_chr7_13971374_ENST00000403685_length(amino acids)=361AA_BP=69
MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPRE
GRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEK
GPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNY
DKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYV

--------------------------------------------------------------

>43053_43053_67_KLK2-ETV1_KLK2_chr19_51378136_ENST00000358049_ETV1_chr7_13971374_ENST00000405192_length(amino acids)=338AA_BP=69
MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPRE
GRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSGCMFEKGPRQFYDDTCVVPEKFDGDIKQE
PGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGER

--------------------------------------------------------------

>43053_43053_68_KLK2-ETV1_KLK2_chr19_51378136_ENST00000358049_ETV1_chr7_13971374_ENST00000405218_length(amino acids)=361AA_BP=69
MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPRE
GRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEK
GPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNY
DKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYV

--------------------------------------------------------------

>43053_43053_69_KLK2-ETV1_KLK2_chr19_51378136_ENST00000358049_ETV1_chr7_13971374_ENST00000405358_length(amino acids)=361AA_BP=69
MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPRE
GRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEK
GPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNY
DKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYV

--------------------------------------------------------------

>43053_43053_70_KLK2-ETV1_KLK2_chr19_51378136_ENST00000358049_ETV1_chr7_13971374_ENST00000420159_length(amino acids)=361AA_BP=69
MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPRE
GRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEK
GPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNY
DKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYV

--------------------------------------------------------------

>43053_43053_71_KLK2-ETV1_KLK2_chr19_51378136_ENST00000358049_ETV1_chr7_13971374_ENST00000430479_length(amino acids)=361AA_BP=69
MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKKFRRQLSEPCNSFPPLPTMPRE
GRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEK
GPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNY
DKLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHFDESMAYMPEGGCCNPHPYNEGYV

--------------------------------------------------------------

>43053_43053_72_KLK2-ETV1_KLK2_chr19_51378136_ENST00000358049_ETV1_chr7_13975521_ENST00000430479_length(amino acids)=424AA_BP=69
MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKNAYDQKPQVGMRPSNPPTPSST
PVSPLHHASPNSTHTPKPDRAFPAHLPPSQSIPDSSYPMDHRFRRQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHD
PVYEHNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMY
REGPTYQRRGSLQLWQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQKVAGERYVYK

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:51376775/chr7:13971374)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
KLK2 P20151	ETV1 P50549
FUNCTION: Glandular kallikreins cleave Met-Lys and Arg-Ser bonds in kininogen to release Lys-bradykinin.	FUNCTION: Transcriptional activator that binds to DNA sequences containing the consensus pentanucleotide 5'-CGGA[AT]-3' (PubMed:7651741). Required for olfactory dopaminergic neuron differentiation; may directly activate expression of tyrosine hydroxylase (TH) (By similarity). {ECO:0000250\|UniProtKB:P41164, ECO:0000269\|PubMed:7651741}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ETV1

chr19:51376774

chr7:13950931

ENST00000242066

335_415

249.33333333333334

460.0

DNA binding

ETS

Tgene

ETV1

chr19:51376774

chr7:13950931

ENST00000343495

335_415

249.33333333333334

460.0

DNA binding

ETS

Tgene

ETV1

chr19:51376774

chr7:13950931

ENST00000399357

335_415

164.33333333333334

375.0

DNA binding

ETS

Tgene

ETV1

chr19:51376774

chr7:13950931

ENST00000403527

335_415

227.33333333333334

438.0

DNA binding

ETS

Tgene

ETV1

chr19:51376774

chr7:13950931

ENST00000403685

335_415

249.33333333333334

460.0

DNA binding

ETS

Tgene

ETV1

chr19:51376774

chr7:13950931

ENST00000405192

335_415

455.0

DNA binding

ETS

Tgene

ETV1

chr19:51376774

chr7:13950931

ENST00000405218

335_415

267.3333333333333

478.0

DNA binding

ETS

Tgene

ETV1

chr19:51376774

chr7:13950931

ENST00000420159

335_415

209.33333333333334

420.0

DNA binding

ETS

Tgene

ETV1

chr19:51376774

chr7:13950931

ENST00000430479

335_415

267.3333333333333

478.0

DNA binding

ETS

Tgene

ETV1

chr19:51378135

chr7:13971373

ENST00000242066

335_415

166.66666666666666

460.0

DNA binding

ETS

Tgene

ETV1

chr19:51378135

chr7:13971373

ENST00000343495

335_415

166.66666666666666

460.0

DNA binding

ETS

Tgene

ETV1

chr19:51378135

chr7:13971373

ENST00000399357

335_415

81.66666666666667

375.0

DNA binding

ETS

Tgene

ETV1

chr19:51378135

chr7:13971373

ENST00000403527

335_415

144.66666666666666

438.0

DNA binding

ETS

Tgene

ETV1

chr19:51378135

chr7:13971373

ENST00000403685

335_415

166.66666666666666

460.0

DNA binding

ETS

Tgene

ETV1

chr19:51378135

chr7:13971373

ENST00000405192

335_415

184.66666666666666

455.0

DNA binding

ETS

Tgene

ETV1

chr19:51378135

chr7:13971373

ENST00000405218

335_415

184.66666666666666

478.0

DNA binding

ETS

Tgene

ETV1

chr19:51378135

chr7:13971373

ENST00000420159

335_415

126.66666666666667

420.0

DNA binding

ETS

Tgene

ETV1

chr19:51378135

chr7:13971373

ENST00000430479

335_415

184.66666666666666

478.0

DNA binding

ETS

Tgene

ETV1

chr19:51378136

chr7:13971374

ENST00000242066

335_415

166.66666666666666

460.0

DNA binding

ETS

Tgene

ETV1

chr19:51378136

chr7:13971374

ENST00000343495

335_415

166.66666666666666

460.0

DNA binding

ETS

Tgene

ETV1

chr19:51378136

chr7:13971374

ENST00000399357

335_415

81.66666666666667

375.0

DNA binding

ETS

Tgene

ETV1

chr19:51378136

chr7:13971374

ENST00000403527

335_415

144.66666666666666

438.0

DNA binding

ETS

Tgene

ETV1

chr19:51378136

chr7:13971374

ENST00000403685

335_415

166.66666666666666

460.0

DNA binding

ETS

Tgene

ETV1

chr19:51378136

chr7:13971374

ENST00000405192

335_415

184.66666666666666

455.0

DNA binding

ETS

Tgene

ETV1

chr19:51378136

chr7:13971374

ENST00000405218

335_415

184.66666666666666

478.0

DNA binding

ETS

Tgene

ETV1

chr19:51378136

chr7:13971374

ENST00000420159

335_415

126.66666666666667

420.0

DNA binding

ETS

Tgene

ETV1

chr19:51378136

chr7:13971374

ENST00000430479

335_415

184.66666666666666

478.0

DNA binding

ETS

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

KLK2

chr19:51376774

chr7:13950931

ENST00000325321

25_258

15.333333333333334

262.0

Domain

Peptidase S1

Hgene

KLK2

chr19:51376774

chr7:13950931

ENST00000358049

25_258

15.333333333333334

224.0

Domain

Peptidase S1

Hgene

KLK2

chr19:51376774

chr7:13950931

ENST00000391810

25_258

160.0

Domain

Peptidase S1

Hgene

KLK2

chr19:51378135

chr7:13971373

ENST00000325321

25_258

68.66666666666667

262.0

Domain

Peptidase S1

Hgene

KLK2

chr19:51378135

chr7:13971373

ENST00000358049

25_258

68.66666666666667

224.0

Domain

Peptidase S1

Hgene

KLK2

chr19:51378135

chr7:13971373

ENST00000391810

25_258

160.0

Domain

Peptidase S1

Hgene

KLK2

chr19:51378136

chr7:13971374

ENST00000325321

25_258

68.66666666666667

262.0

Domain

Peptidase S1

Hgene

KLK2

chr19:51378136

chr7:13971374

ENST00000358049

25_258

68.66666666666667

224.0

Domain

Peptidase S1

Hgene

KLK2

chr19:51378136

chr7:13971374

ENST00000391810

25_258

160.0

Domain

Peptidase S1

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (185) >>>185.pdbFusion protein BP residue: 69 CIF file (185) >>>185.cif	KLK2	chr19	51378136	+	ETV1	chr7	13975521	-	MWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKHSQPWQVAVYSHGWAHC GGVLVHPQWVLTAAHCLKNAYDQKPQVGMRPSNPPTPSSTPVSPLHHASP NSTHTPKPDRAFPAHLPPSQSIPDSSYPMDHRFRRQLSEPCNSFPPLPTM PREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYEHNTMVGSAASQSFPPP LMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPSRTEGCMFEKGPRQFYD DTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQLWQFLVALLDDPSNSHF IAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYDKLSRSLRYYYEKGIMQ KVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTDMERHINEEDTVPLSHF	424
3D view using mol* of 185 (AA BP:69)


PDB file (284) >>>284.pdbFusion protein BP residue: 135 CIF file (284) >>>284.cif	KLK2	chr19	51378136	+	ETV1	chr7	13975521	-	MALPPLPQLWVWEGVVQPPAAWGGPWSASRCQQGKGGVLENEGFIGLLRE APQPQTHHLAVDTCVSMWDLVLSIALSVGCTGAVPLIQSRIVGGWECEKH SQPWQVAVYSHGWAHCGGVLVHPQWVLTAAHCLKNAYDQKPQVGMRPSNP PTPSSTPVSPLHHASPNSTHTPKPDRAFPAHLPPSQSIPDSSYPMDHRFR RQLSEPCNSFPPLPTMPREGRPMYQRQMSEPNIPFPPQGFKQEYHDPVYE HNTMVGSAASQSFPPPLMIKQEPRDFAYDSEVPSCHSIYMRQEGFLAHPS RTEGCMFEKGPRQFYDDTCVVPEKFDGDIKQEPGMYREGPTYQRRGSLQL WQFLVALLDDPSNSHFIAWTGRGMEFKLIEPEEVARRWGIQKNRPAMNYD KLSRSLRYYYEKGIMQKVAGERYVYKFVCDPEALFSMAFPDNQRPLLKTD	490
3D view using mol* of 284 (AA BP:135)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

KLK2_pLDDT.png

ETV1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

KLK2_ETV1_185_pLDDT.png (AA BP:69)

KLK2_ETV1_185_pLDDT_and_active_sites.png (AA BP:69)

KLK2_ETV1_185_violinplot.png (AA BP:69)

KLK2_ETV1_284_pLDDT.png (AA BP:135)

KLK2_ETV1_284_pLDDT_and_active_sites.png (AA BP:135)

KLK2_ETV1_284_violinplot.png (AA BP:135)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

KLK2_ETV1_185.png

KLK2_ETV1_284.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
185	0.96	76	1.029	273.028	0.724	0.627	0.75	1.06	0.512	2.072	1.077	Chain A: 38,53,54,55,56,57,285,289,307,308,350,360 ,361,362,363,368,371,372
284	1.018	89	1.092	514.157	0.729	0.651	0.822	1.233	0.568	2.17	0.706	Chain A: 9,10,11,12,13,14,15,108,121,124,125,126,1 27,128,129,130,131,133,351,355,374,427,428,429,430 ,431,434,435,437,438,439

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB	ZINC ID	DrugBank ID	Drug name	Docking score	Glide gscore
185	ZINC000049637509	DB06636	Isavuconazonium	-7.43113	-9.33583
185	ZINC000003938482	DB01263	Posaconazole	-8.22696	-8.24466
185	ZINC000012503187	DB00872	Conivaptan	-7.735	-8.1265
185	ZINC000000056645	DB00960	Pindolol	-7.08074	-7.08244
185	ZINC000222731806	DB13874	Enasidenib	-6.94072	-6.94072
185	ZINC000004213946	DB04861	Nebivolol	-6.88711	-6.90691
185	ZINC000027990463	DB08827	Lomitapide	-6.88579	-6.88889
185	ZINC000011679756	DB06210	Eltrombopag	-6.82739	-6.83219
185	ZINC000005844788	DB04861	Nebivolol	-6.78279	-6.80259
185	ZINC000008551179	DB00798	Gentamicin	-6.55687	-6.74217
185	Pexidartinib	DB00798		-5.97084	-6.67164
185	ZINC000000897291	DB00754	Ethotoin	-6.67157	-6.67157
185	ZINC000004097344	DB01167	Itraconazole	-4.69678	-6.66828
185	ZINC000004074875	DB00796	Candesartan cilexetil	-5.80204	-6.66794
185	ZINC000060183170	DB01421	Paromomycin	-6.02816	-6.65356
185	ZINC000004097343	DB01167	Itraconazole	-4.66294	-6.63444
185	ZINC000000000931	DB00543	Amoxapine	-6.5709	-6.5843
185	ZINC000036701290	DB08901	Ponatinib	-6.36219	-6.56879
185	ZINC000000056646	DB00960	Pindolol	-6.55839	-6.56009
185	ZINC000004474682	DB00287	Travoprost	-6.51687	-6.51687

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID	DrugBank ID	Drug name	Drug type	SMILES	Drug group
ZINC000049637509	DB06636	Isavuconazonium	Small molecule	[H]C(C)(OC(=O)N(C)C1=C(COC(=O)CNC)C=CC=N1)[N+]1=CN(C[C@](O)(C2=C(F)C=CC(F)=C2)[C@@]([H])(C)C2=NC(=CS2)C2=CC=C(C=C2)C#N)N=C1	Approved\|Investigational
ZINC000003938482	DB01263	Posaconazole	Small molecule	[H][C@@](C)(O)[C@]([H])(CC)N1N=CN(C1=O)C1=CC=C(C=C1)N1CCN(CC1)C1=CC=C(OC[C@]2([H])CO[C@](CN3C=NC=N3)(C2)C2=C(F)C=C(F)C=C2)C=C1	Approved\|Investigational\|Vet_approved
ZINC000012503187	DB00872	Conivaptan	Small molecule	CC1=NC2=C(CCN(C(=O)C3=CC=C(NC(=O)C4=CC=CC=C4C4=CC=CC=C4)C=C3)C3=CC=CC=C23)N1	Approved\|Investigational
ZINC000000056645	DB00960	Pindolol	Small molecule	CC(C)NCC(O)COC1=CC=CC2=C1C=CN2	Approved\|Investigational
ZINC000222731806	DB13874	Enasidenib	Small molecule	CC(C)(O)CNC1=NC(=NC(NC2=CC(=NC=C2)C(F)(F)F)=N1)C1=NC(=CC=C1)C(F)(F)F	Approved\|Investigational
ZINC000027990463	DB08827	Lomitapide	Small molecule	FC(F)(F)CNC(=O)C1(CCCCN2CCC(CC2)NC(=O)C2=C(C=CC=C2)C2=CC=C(C=C2)C(F)(F)F)C2=CC=CC=C2C2=CC=CC=C12	Approved\|Investigational
ZINC000011679756	DB06210	Eltrombopag	Small molecule	CC1=NN(C(=O)C1=N/NC1=CC=CC(C2=CC=CC(=C2)C(O)=O)=C1O)C1=CC=C(C)C(C)=C1	Approved
ZINC000000897291	DB00754	Ethotoin	Small molecule	CCN1C(=O)NC(C1=O)C1=CC=CC=C1	Approved
ZINC000004097344	DB01167	Itraconazole	Small molecule	CCC(C)N1N=CN(C1=O)C1=CC=C(C=C1)N1CCN(CC1)C1=CC=C(OC[C@H]2CO[C@@](CN3C=NC=N3)(O2)C2=CC=C(Cl)C=C2Cl)C=C1	Approved\|Investigational
ZINC000060183170	DB01421	Paromomycin	Small molecule	NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O	Approved\|Investigational
ZINC000000000931	DB00543	Amoxapine	Small molecule	ClC1=CC2=C(OC3=CC=CC=C3N=C2N2CCNCC2)C=C1	Approved
ZINC000036701290	DB08901	Ponatinib	Small molecule	CN1CCN(CC2=CC=C(NC(=O)C3=CC(C#CC4=CN=C5C=CC=NN45)=C(C)C=C3)C=C2C(F)(F)F)CC1	Approved\|Investigational
ZINC000004474682	DB00287	Travoprost	Small molecule	CC(C)OC(=O)CCCC=C/C[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1C=C[C@@H](O)COC1=CC=CC(=C1)C(F)(F)F	Approved

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID	mol_MW	dipole	SASA	FOSA	FISA	PISA	WPSA	volume	donorHB	accptHB	IP	Human Oral Absorption	Percent Human Oral Absorption	Rule Of Five	Rule Of Three
ZINC000003938482	700.787	6.593	1133.73	453.341	130.579	474.963	74.848	2110.183	1	11.2	8.262	1	82.417	3	1
ZINC000003938482	700.787	8.545	1114.625	456.955	127.996	456.482	73.192	2101.798	1	11.2	8.612	1	82.52	3	1
ZINC000012503187	498.583	11.564	760.246	179.154	103.146	477.945	0	1480.012	2	7	8.764	1	100	1	1
ZINC000012503187	498.583	1.533	824.155	177.303	91.635	555.217	0	1541.389	2	7	8.689	1	100	1	1
ZINC000012503187	498.583	11.58	761.574	177.145	102.951	481.477	0	1478.963	2	7	8.755	1	100	1	1
ZINC000000056645	248.324	4.324	555.397	250.183	78.936	226.279	0	920.854	3	3.95	8.124	3	84.528	0	0
ZINC000222731806	473.38	5.655	726.935	159.39	113.252	236.596	217.697	1294.132	3	6.75	9.233	1	100	0	1
ZINC000004213946	405.441	5.213	712.775	270.546	87.695	260.773	93.761	1260.01	3	6.4	9.251	3	94.555	0	0
ZINC000004213946	405.441	3.313	660.255	261.068	75.583	229.844	93.76	1216.093	3	6.4	9.124	3	95.533	0	0
ZINC000027990463	693.731	9.819	1082.565	277.602	57.032	525.312	222.618	2026.285	2	7	9.293	1	100	2	1
ZINC000027990463	693.731	5.182	1032.195	249.812	56.285	513.578	212.521	1985.783	2	7	9.074	1	100	2	1
ZINC000011679756	442.473	4.859	790.6	238.654	197.38	354.566	0	1392.94	2	7.25	8.428	1	80.006	0	1
ZINC000005844788	405.441	1.102	724.6	273.703	87.795	269.339	93.762	1272.257	3	6.4	9.305	3	94.995	0	0
ZINC000005844788	405.441	3.204	688.14	293.004	60.761	240.615	93.76	1244.959	3	6.4	9.151	3	100	0	0
ZINC000008551179	477.6	2.427	700.578	455.572	245.006	0	0	1422.232	11	16.95	9.206	1	0	2	2
ZINC000008551179	477.6	2.141	752.31	520.048	232.262	0	0	1477.265	11	16.95	9.056	1	0	2	2
ZINC000008551179	477.6	1.697	714.306	455.762	258.544	0	0	1421.04	11	16.95	9.046	1	0	2	2
ZINC000008551179	477.6	0.842	707.428	469.03	238.398	0	0	1416.646	11	16.95	9.151	1	0	2	2
ZINC000008551179	477.6	2.926	704.544	467.567	236.977	0	0	1417.31	11	16.95	8.988	1	0	2	2
ZINC000000897291	204.228	3.869	431.423	142.513	103.489	185.421	0	709.496	1	3.5	9.903	3	91.55	0	0
ZINC000004097344	705.642	7.201	1108.356	441.228	93.993	451.204	121.931	2059.909	0	10.25	8.234	1	76.931	3	1
ZINC000004097344	705.642	9.231	1077.094	456.708	94.986	424.927	100.473	2039.22	0	10.25	8.496	1	77.441	3	1
ZINC000004074875	610.668	9.465	905.55	434.072	175.109	296.369	0	1777.81	1	8.5	8.947	1	65.033	3	1
ZINC000004074875	610.668	9.602	867.188	385.977	165.449	315.761	0	1731.935	1	8.5	8.884	1	65.552	3	1
ZINC000060183170	615.634	6.469	852.379	333.487	518.892	0	0	1659.281	18	28.8	9.349	1	0	3	2
ZINC000060183170	615.634	3.96	880.798	394.277	486.521	0	0	1692.314	18	28.8	9.305	1	0	3	2
ZINC000060183170	615.634	5.103	837.174	322.647	514.527	0	0	1660.785	18	28.8	9.222	1	0	3	2
ZINC000060183170	615.634	2.705	864.842	336.076	528.766	0	0	1662.115	18	28.8	9.424	1	0	3	2
ZINC000060183170	615.634	5.505	857.834	356.773	501.061	0	0	1653.731	18	28.8	9.025	1	0	3	2
ZINC000060183170	615.634	4.108	857.637	355.734	501.903	0	0	1653.789	18	28.8	9.107	1	0	3	2
ZINC000060183170	615.634	7.059	842.213	356.118	486.095	0	0	1655.763	18	28.8	9.1	1	0	3	2
ZINC000060183170	615.634	7.013	831.783	339.851	491.933	0	0	1655.638	18	28.8	9.196	1	0	3	2
ZINC000060183170	615.634	9.322	830.127	345.166	484.961	0	0	1649.249	18	28.8	9.438	1	0	3	2
ZINC000060183170	615.634	6.26	774.039	316.84	457.199	0	0	1589.578	18	28.8	9.166	1	0	3	2
ZINC000060183170	615.634	7.054	839.2	337.172	502.027	0	0	1650.058	18	28.8	9.355	1	0	3	2
ZINC000004097343	705.642	7.181	1151.617	480.956	96.274	452.325	122.062	2102.052	0	10.25	8.242	1	77.792	3	1
ZINC000004097343	705.642	2.898	1052.809	447.535	82.593	408.226	114.455	2020.51	0	10.25	8.414	1	79.553	3	1
ZINC000000000931	313.786	0.596	539.202	164.064	40.627	265.753	68.759	951.598	1	3.5	8.505	3	100	0	0
ZINC000000000931	313.786	2.237	535.87	161.607	40.638	264.946	68.678	946.757	1	3.5	8.399	3	100	0	0
ZINC000036701290	532.567	7.296	915.546	310.158	106.613	405.085	93.689	1633.531	1	9.5	8.988	1	72.323	1	1
ZINC000036701290	532.567	4.435	904.567	311.4	106.915	392.831	93.42	1625.419	1	9.5	9.023	2	71.892	1	1
ZINC000036701290	532.567	10.427	912.404	310.981	99.059	408.312	94.052	1630.814	1	9.5	8.961	2	73.847	1	1
ZINC000000056646	248.324	3.713	555.406	250.19	78.935	226.282	0	920.921	3	3.95	8.127	3	84.528	0	0
ZINC000004474682	500.554	7.814	798.264	377.787	163.81	139.044	117.622	1521.375	3	7.85	9.535	3	85.406	1	2

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID	Smile	Surface Accessibility	Toxicity
ZINC000049637509	CNCC(=O)OCc1cccnc1N(C)C(=O)O[C@@H](C)[n+]1cnn(C[C@](O)(c2cc(F)ccc2F)[C@@H](C)c2nc(-c3ccc(C#N)cc3)cs2)c1	0.025416027	0.235213823
ZINC000003938482	CC[C@@H]([C@H](C)O)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@@H]5CO[C@@](Cn6cncn6)(c6ccc(F)cc6F)C5)cc4)CC3)cc2)c1=O	0.031724381	0.429306683
ZINC000012503187	Cc1nc2c([nH]1)-c1ccccc1N(C(=O)c1ccc(NC(=O)c3ccccc3-c3ccccc3)cc1)CC2	0.227321865	0.16373356
ZINC000000056645	CC(C)NC[C@H](O)COc1cccc2[nH]ccc12	0.191796685	0.263927459
ZINC000222731806	CC(C)(O)CNc1nc(Nc2ccnc(C(F)(F)F)c2)nc(-c2cccc(C(F)(F)F)n2)n1	0.135991961	0.352663023
ZINC000004213946	O[C@@H](CNC[C@@H](O)[C@@H]1CCc2cc(F)ccc2O1)[C@@H]1CCc2cc(F)ccc2O1	0.055550082	0.198725964
ZINC000027990463	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	0.141091549	0.274261494
ZINC000011679756	CC1=NN(c2ccc(C)c(C)c2)C(=O)/C1=NNc1cccc(-c2cccc(C(=O)O)c2)c1O	0.209399624	0.357966867
ZINC000005844788	O[C@@H](CNC[C@@H](O)[C@H]1CCc2cc(F)ccc2O1)[C@@H]1CCc2cc(F)ccc2O1	0.055550082	0.198725964
ZINC000008551179	CN[C@@H](C)[C@H]1CC[C@@H](N)[C@@H](O[C@@H]2[C@@H](N)C[C@@H](N)[C@@H](O[C@@H]3OC[C@@](C)(O)[C@@H](NC)[C@@H]3O)[C@@H]2O)O1	0.013265241	0.371016745
ZINC000000897291	CCN1C(=O)N[C@@H](c2ccccc2)C1=O	0.216764475	0.437555471
ZINC000004097344	CC[C@H](C)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@H]5CO[C@](Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	0.044363286	0.444547752
ZINC000004074875	CCOc1nc2cccc(C(=O)O[C@H](C)OC(=O)OC3CCCCC3)c2n1Cc1ccc(-c2ccccc2-c2nn[nH]n2)cc1	0.085535269	0.250585506
ZINC000060183170	NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O	0.010995771	0.270848186
ZINC000004097343	CC[C@@H](C)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@H]5CO[C@](Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O	0.044363286	0.444547752
ZINC000000000931	Clc1ccc2c(c1)C(N1CCNCC1)=Nc1ccccc1O2	0.246251318	0.464146993
ZINC000036701290	Cc1ccc(C(=O)Nc2ccc(CN3CCN(C)CC3)c(C(F)(F)F)c2)cc1C#Cc1cnc2cccnn12	0.143352927	0.289072356
ZINC000000056646	CC(C)NC[C@@H](O)COc1cccc2[nH]ccc12	0.191796685	0.263927459
ZINC000004474682	CC(C)OC(=O)CCC/C=CC[C@H]1[C@@H](O)C[C@@H](O)[C@@H]1/C=C/[C@@H](O)COc1cccc(C(F)(F)F)c1	0.043771914	0.166030074

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
KLK2	SERPINF2, SERPINA3, SERPINA5, SERPINB6, APP, SUZ12, RNF2, ADAMTS1, SERPINE2, APLP2, GLG1, EXT2, BMP1, PIGT, FGFR4, MAN2B2, SUMF1, LRP6, JAG2, IL17RA, GALNT18, CERCAM, CHID1, PGAM2, ERGIC1, ROR2, PCSK9, B4GALT3, PCSK6, ARSK, MAN2A2, MANBA,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
KLK2
ETV1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to KLK2-ETV1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to KLK2-ETV1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	KLK2	C0033578	Prostatic Neoplasms	2	CTD_human
Hgene	KLK2	C0376358	Malignant neoplasm of prostate	2	CTD_human
Tgene	ETV1	C0033578	Prostatic Neoplasms	3	CTD_human
Tgene	ETV1	C0376358	Malignant neoplasm of prostate	3	CTD_human
Tgene	ETV1	C0009402	Colorectal Carcinoma	1	CTD_human
Tgene	ETV1	C0009404	Colorectal Neoplasms	1	CTD_human