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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:LRP6-PTPRO

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: LRP6-PTPRO
FusionPDB ID: 49835
FusionGDB2.0 ID: 49835
HgeneTgene
Gene symbol

LRP6

PTPRO

Gene ID

4040

10076

Gene nameLDL receptor related protein 6protein tyrosine phosphatase receptor type U
SynonymsADCAD2|STHAG7FMI|PCP-2|PTP|PTP-J|PTP-PI|PTP-RO|PTPPSI|PTPRO|PTPU2|R-PTP-PSI|R-PTP-U|hPTP-J
Cytomap

12p13.2

1p35.3

Type of geneprotein-codingprotein-coding
Descriptionlow-density lipoprotein receptor-related protein 6LRP-6receptor-type tyrosine-protein phosphatase UPTP piReceptor protein tyrosine phosphatase hPTP-Jpancreatic carcinoma phosphatase 2pi R-PTP-Psiprotein-tyrosine phosphatase Jprotein-tyrosine phosphatase piprotein-tyrosine phosphatase receptor omicronr
Modification date2020032920200313
UniProtAcc

O75581

.
Ensembl transtripts involved in fusion geneENST idsENST00000261349, ENST00000543091, 
ENST00000540415, 		ENST00000543886, 
ENST00000544706, ENST00000281171, 
ENST00000348962, ENST00000442921, 
ENST00000445537, ENST00000542557, 
ENST00000544244, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 12 X 8=124810 X 11 X 6=660
# samples 1811
** MAII scorelog2(18/1248*10)=-2.79354912253257
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(11/660*10)=-2.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: LRP6 [Title/Abstract] AND PTPRO [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)LRP6(12332744)-PTPRO(15733631), # samples:3
Anticipated loss of major functional domain due to fusion event.LRP6-PTPRO seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LRP6-PTPRO seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
LRP6-PTPRO seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
LRP6-PTPRO seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneLRP6

GO:0014029

neural crest formation

11029007

HgeneLRP6

GO:0014033

neural crest cell differentiation

11029007

HgeneLRP6

GO:0016055

Wnt signaling pathway

11357136

HgeneLRP6

GO:0045944

positive regulation of transcription by RNA polymerase II

12857724

HgeneLRP6

GO:0051091

positive regulation of DNA-binding transcription factor activity

14739301

HgeneLRP6

GO:0060070

canonical Wnt signaling pathway

11448771|11742004|12121999|14739301|15271658|15908424|16263759|16543246|17239604|19107203|20059949|20093106|20137080

HgeneLRP6

GO:0071901

negative regulation of protein serine/threonine kinase activity

19107203

TgenePTPRO

GO:0006470

protein dephosphorylation

12501215

TgenePTPRO

GO:0008285

negative regulation of cell proliferation

16574648

TgenePTPRO

GO:0030336

negative regulation of cell migration

12501215|16574648

TgenePTPRO

GO:0034394

protein localization to cell surface

16574648

TgenePTPRO

GO:0090090

negative regulation of canonical Wnt signaling pathway

16574648

TgenePTPRO

GO:2000049

positive regulation of cell-cell adhesion mediated by cadherin

16574648


check buttonFusion gene breakpoints across LRP6 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PTPRO (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PAADTCGA-F2-6879-01ALRP6chr12

12332744

-PTPROchr12

15733631

+
ChimerDB4PAADTCGA-F2-6879LRP6chr12

12332743

-PTPROchr12

15733630

+
ChimerDB4PAADTCGA-F2-6879LRP6chr12

12332744

-PTPROchr12

15733631

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261349LRP6chr1212332744-ENST00000281171PTPROchr1215733631+35961622772275732
ENST00000261349LRP6chr1212332744-ENST00000348962PTPROchr1215733631+35961622772275732
ENST00000261349LRP6chr1212332744-ENST00000542557PTPROchr1215733631+36021622772275732
ENST00000261349LRP6chr1212332744-ENST00000544244PTPROchr1215733631+46341622772275732
ENST00000261349LRP6chr1212332744-ENST00000445537PTPROchr1215733631+46341622772275732
ENST00000261349LRP6chr1212332744-ENST00000442921PTPROchr1215733631+36021622772275732
ENST00000543091LRP6chr1212332744-ENST00000281171PTPROchr1215733631+35531579342232732
ENST00000543091LRP6chr1212332744-ENST00000348962PTPROchr1215733631+35531579342232732
ENST00000543091LRP6chr1212332744-ENST00000542557PTPROchr1215733631+35591579342232732
ENST00000543091LRP6chr1212332744-ENST00000544244PTPROchr1215733631+45911579342232732
ENST00000543091LRP6chr1212332744-ENST00000445537PTPROchr1215733631+45911579342232732
ENST00000543091LRP6chr1212332744-ENST00000442921PTPROchr1215733631+35591579342232732
ENST00000261349LRP6chr1212332743-ENST00000281171PTPROchr1215733630+35961622772275732
ENST00000261349LRP6chr1212332743-ENST00000348962PTPROchr1215733630+35961622772275732
ENST00000261349LRP6chr1212332743-ENST00000542557PTPROchr1215733630+36021622772275732
ENST00000261349LRP6chr1212332743-ENST00000544244PTPROchr1215733630+46341622772275732
ENST00000261349LRP6chr1212332743-ENST00000445537PTPROchr1215733630+46341622772275732
ENST00000261349LRP6chr1212332743-ENST00000442921PTPROchr1215733630+36021622772275732
ENST00000543091LRP6chr1212332743-ENST00000281171PTPROchr1215733630+35531579342232732
ENST00000543091LRP6chr1212332743-ENST00000348962PTPROchr1215733630+35531579342232732
ENST00000543091LRP6chr1212332743-ENST00000542557PTPROchr1215733630+35591579342232732
ENST00000543091LRP6chr1212332743-ENST00000544244PTPROchr1215733630+45911579342232732
ENST00000543091LRP6chr1212332743-ENST00000445537PTPROchr1215733630+45911579342232732
ENST00000543091LRP6chr1212332743-ENST00000442921PTPROchr1215733630+35591579342232732

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261349ENST00000281171LRP6chr1212332744-PTPROchr1215733631+0.0009394390.9990606
ENST00000261349ENST00000348962LRP6chr1212332744-PTPROchr1215733631+0.0009394390.9990606
ENST00000261349ENST00000542557LRP6chr1212332744-PTPROchr1215733631+0.0009265760.9990734
ENST00000261349ENST00000544244LRP6chr1212332744-PTPROchr1215733631+0.00093120.9990688
ENST00000261349ENST00000445537LRP6chr1212332744-PTPROchr1215733631+0.00093120.9990688
ENST00000261349ENST00000442921LRP6chr1212332744-PTPROchr1215733631+0.0009265760.9990734
ENST00000543091ENST00000281171LRP6chr1212332744-PTPROchr1215733631+0.0009145880.9990854
ENST00000543091ENST00000348962LRP6chr1212332744-PTPROchr1215733631+0.0009145880.9990854
ENST00000543091ENST00000542557LRP6chr1212332744-PTPROchr1215733631+0.0009034530.9990965
ENST00000543091ENST00000544244LRP6chr1212332744-PTPROchr1215733631+0.0009114030.99908864
ENST00000543091ENST00000445537LRP6chr1212332744-PTPROchr1215733631+0.0009114030.99908864
ENST00000543091ENST00000442921LRP6chr1212332744-PTPROchr1215733631+0.0009034530.9990965
ENST00000261349ENST00000281171LRP6chr1212332743-PTPROchr1215733630+0.0009394390.9990606
ENST00000261349ENST00000348962LRP6chr1212332743-PTPROchr1215733630+0.0009394390.9990606
ENST00000261349ENST00000542557LRP6chr1212332743-PTPROchr1215733630+0.0009265760.9990734
ENST00000261349ENST00000544244LRP6chr1212332743-PTPROchr1215733630+0.00093120.9990688
ENST00000261349ENST00000445537LRP6chr1212332743-PTPROchr1215733630+0.00093120.9990688
ENST00000261349ENST00000442921LRP6chr1212332743-PTPROchr1215733630+0.0009265760.9990734
ENST00000543091ENST00000281171LRP6chr1212332743-PTPROchr1215733630+0.0009145880.9990854
ENST00000543091ENST00000348962LRP6chr1212332743-PTPROchr1215733630+0.0009145880.9990854
ENST00000543091ENST00000542557LRP6chr1212332743-PTPROchr1215733630+0.0009034530.9990965
ENST00000543091ENST00000544244LRP6chr1212332743-PTPROchr1215733630+0.0009114030.99908864
ENST00000543091ENST00000445537LRP6chr1212332743-PTPROchr1215733630+0.0009114030.99908864
ENST00000543091ENST00000442921LRP6chr1212332743-PTPROchr1215733630+0.0009034530.9990965

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>49835_49835_1_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000261349_PTPRO_chr12_15733630_ENST00000281171_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_2_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000261349_PTPRO_chr12_15733630_ENST00000348962_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_3_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000261349_PTPRO_chr12_15733630_ENST00000442921_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_4_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000261349_PTPRO_chr12_15733630_ENST00000445537_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_5_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000261349_PTPRO_chr12_15733630_ENST00000542557_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_6_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000261349_PTPRO_chr12_15733630_ENST00000544244_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_7_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000543091_PTPRO_chr12_15733630_ENST00000281171_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_8_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000543091_PTPRO_chr12_15733630_ENST00000348962_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_9_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000543091_PTPRO_chr12_15733630_ENST00000442921_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_10_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000543091_PTPRO_chr12_15733630_ENST00000445537_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_11_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000543091_PTPRO_chr12_15733630_ENST00000542557_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_12_LRP6-PTPRO_LRP6_chr12_12332743_ENST00000543091_PTPRO_chr12_15733630_ENST00000544244_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_13_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000261349_PTPRO_chr12_15733631_ENST00000281171_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_14_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000261349_PTPRO_chr12_15733631_ENST00000348962_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_15_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000261349_PTPRO_chr12_15733631_ENST00000442921_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_16_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000261349_PTPRO_chr12_15733631_ENST00000445537_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_17_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000261349_PTPRO_chr12_15733631_ENST00000542557_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_18_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000261349_PTPRO_chr12_15733631_ENST00000544244_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_19_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000543091_PTPRO_chr12_15733631_ENST00000281171_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_20_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000543091_PTPRO_chr12_15733631_ENST00000348962_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_21_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000543091_PTPRO_chr12_15733631_ENST00000442921_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_22_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000543091_PTPRO_chr12_15733631_ENST00000445537_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_23_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000543091_PTPRO_chr12_15733631_ENST00000542557_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

>49835_49835_24_LRP6-PTPRO_LRP6_chr12_12332744_ENST00000543091_PTPRO_chr12_15733631_ENST00000544244_length(amino acids)=732AA_BP=515
MGAVLRSLLACSFCVLLRAAPLLLYANRRDLRLVDATNGKENATIVVGGLEDAAAVDFVFSHGLIYWSDVSEEAIKRTEFNKTESVQNVV
VSGLLSPDGLACDWLGEKLYWTDSETNRIEVSNLDGSLRKVLFWQELDQPRAIALDPSSGFMYWTDWGEVPKIERAGMDGSSRFIIINSE
IYWPNGLTLDYEEQKLYWADAKLNFIHKSNLDGTNRQAVVKGSLPHPFALTLFEDILYWTDWSTHSILACNKYTGEGLREIHSDIFSPMD
IHAFSQQRQPNATNPCGIDNGGCSHLCLMSPVKPFYQCACPTGVKLLENGKTCKDGATELLLLARRTDLRRISLDTPDFTDIVLQLEDIR
HAIAIDYDPVEGYIYWTDDEVRAIRRSFIDGSGSQFVVTAQIAHPDGIAVDWVARNLYWTDTGTDRIEVTRLNGTMRKILISEDLEEPRA
IVLDPMVGYMYWTDWGEIPKIERAALDGSDRVVLVNTSLGWPNGLALDYDEGKIYWGDAKTDKIEGYNSPQEYIATQGPLPETRNDFWKM
VLQQKSQIIVMLTQCNEKRRVKCDHYWPFTEEPIAYGDITVEMISEEEQDDWACRHFRINYADEMQDVMHFNYTAWPDHGVPTANAAESI
LQFVHMVRQQATKSKGPMIIHCSAGVGRTGTFIALDRLLQHIRDHEFVDILGLVSEMRSYRMSMVQTEEQYIFIHQCVQLMWMKKKQQFC

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:12332744/chr12:15733631)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
LRP6

O75581

.
FUNCTION: Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Cell-surface coreceptor of Wnt/beta-catenin signaling, which plays a pivotal role in bone formation. The Wnt-induced Fzd/LRP6 coreceptor complex recruits DVL1 polymers to the plasma membrane which, in turn, recruits the AXIN1/GSK3B-complex to the cell surface promoting the formation of signalsomes and inhibiting AXIN1/GSK3-mediated phosphorylation and destruction of beta-catenin. Required for posterior patterning of the epiblast during gastrulation (By similarity). {ECO:0000250, ECO:0000269|PubMed:11357136, ECO:0000269|PubMed:11448771, ECO:0000269|PubMed:15778503, ECO:0000269|PubMed:16341017, ECO:0000269|PubMed:16513652, ECO:0000269|PubMed:17326769, ECO:0000269|PubMed:17400545, ECO:0000269|PubMed:19107203, ECO:0000269|PubMed:19293931, ECO:0000269|PubMed:19801552}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

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* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-723282_324515.01614.0DomainNote=EGF-like 1
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-723282_324515.01614.0DomainNote=EGF-like 1
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-72320_275515.01614.0RegionNote=Beta-propeller 1
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-72320_275515.01614.0RegionNote=Beta-propeller 1
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-723107_149515.01614.0RepeatNote=LDL-receptor class B 2
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-723150_193515.01614.0RepeatNote=LDL-receptor class B 3
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-723194_236515.01614.0RepeatNote=LDL-receptor class B 4
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-723237_276515.01614.0RepeatNote=LDL-receptor class B 5
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-723372_414515.01614.0RepeatNote=LDL-receptor class B 6
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-723415_457515.01614.0RepeatNote=LDL-receptor class B 7
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-723458_501515.01614.0RepeatNote=LDL-receptor class B 8
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-72363_106515.01614.0RepeatNote=LDL-receptor class B 1
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-723107_149515.01614.0RepeatNote=LDL-receptor class B 2
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-723150_193515.01614.0RepeatNote=LDL-receptor class B 3
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-723194_236515.01614.0RepeatNote=LDL-receptor class B 4
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-723237_276515.01614.0RepeatNote=LDL-receptor class B 5
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-723372_414515.01614.0RepeatNote=LDL-receptor class B 6
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-723415_457515.01614.0RepeatNote=LDL-receptor class B 7
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-723458_501515.01614.0RepeatNote=LDL-receptor class B 8
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-72363_106515.01614.0RepeatNote=LDL-receptor class B 1
TgenePTPROchr12:12332743chr12:15733630ENST00000442921815246_306188.0723.6666666666666DomainFibronectin type-III 3
TgenePTPROchr12:12332743chr12:15733630ENST00000442921815329_425188.0723.6666666666666DomainFibronectin type-III 4
TgenePTPROchr12:12332743chr12:15733630ENST00000442921815435_531188.0723.6666666666666DomainFibronectin type-III 5
TgenePTPROchr12:12332743chr12:15733630ENST00000442921815532_628188.0723.6666666666666DomainFibronectin type-III 6
TgenePTPROchr12:12332743chr12:15733630ENST00000442921815631_724188.0723.6666666666666DomainFibronectin type-III 7
TgenePTPROchr12:12332743chr12:15733630ENST00000442921815725_817188.0723.6666666666666DomainFibronectin type-III 8
TgenePTPROchr12:12332743chr12:15733630ENST00000442921815938_1195188.0723.6666666666666DomainTyrosine-protein phosphatase
TgenePTPROchr12:12332743chr12:15733630ENST00000445537814246_306188.0406.0DomainFibronectin type-III 3
TgenePTPROchr12:12332743chr12:15733630ENST00000445537814329_425188.0406.0DomainFibronectin type-III 4
TgenePTPROchr12:12332743chr12:15733630ENST00000445537814435_531188.0406.0DomainFibronectin type-III 5
TgenePTPROchr12:12332743chr12:15733630ENST00000445537814532_628188.0406.0DomainFibronectin type-III 6
TgenePTPROchr12:12332743chr12:15733630ENST00000445537814631_724188.0406.0DomainFibronectin type-III 7
TgenePTPROchr12:12332743chr12:15733630ENST00000445537814725_817188.0406.0DomainFibronectin type-III 8
TgenePTPROchr12:12332743chr12:15733630ENST00000445537814938_1195188.0406.0DomainTyrosine-protein phosphatase
TgenePTPROchr12:12332743chr12:15733630ENST00000542557714246_306160.0695.6666666666666DomainFibronectin type-III 3
TgenePTPROchr12:12332743chr12:15733630ENST00000542557714329_425160.0695.6666666666666DomainFibronectin type-III 4
TgenePTPROchr12:12332743chr12:15733630ENST00000542557714435_531160.0695.6666666666666DomainFibronectin type-III 5
TgenePTPROchr12:12332743chr12:15733630ENST00000542557714532_628160.0695.6666666666666DomainFibronectin type-III 6
TgenePTPROchr12:12332743chr12:15733630ENST00000542557714631_724160.0695.6666666666666DomainFibronectin type-III 7
TgenePTPROchr12:12332743chr12:15733630ENST00000542557714725_817160.0695.6666666666666DomainFibronectin type-III 8
TgenePTPROchr12:12332743chr12:15733630ENST00000542557714938_1195160.0695.6666666666666DomainTyrosine-protein phosphatase
TgenePTPROchr12:12332743chr12:15733630ENST00000544244713246_306160.0378.0DomainFibronectin type-III 3
TgenePTPROchr12:12332743chr12:15733630ENST00000544244713329_425160.0378.0DomainFibronectin type-III 4
TgenePTPROchr12:12332743chr12:15733630ENST00000544244713435_531160.0378.0DomainFibronectin type-III 5
TgenePTPROchr12:12332743chr12:15733630ENST00000544244713532_628160.0378.0DomainFibronectin type-III 6
TgenePTPROchr12:12332743chr12:15733630ENST00000544244713631_724160.0378.0DomainFibronectin type-III 7
TgenePTPROchr12:12332743chr12:15733630ENST00000544244713725_817160.0378.0DomainFibronectin type-III 8
TgenePTPROchr12:12332743chr12:15733630ENST00000544244713938_1195160.0378.0DomainTyrosine-protein phosphatase
TgenePTPROchr12:12332744chr12:15733631ENST00000442921815246_306188.0723.6666666666666DomainFibronectin type-III 3
TgenePTPROchr12:12332744chr12:15733631ENST00000442921815329_425188.0723.6666666666666DomainFibronectin type-III 4
TgenePTPROchr12:12332744chr12:15733631ENST00000442921815435_531188.0723.6666666666666DomainFibronectin type-III 5
TgenePTPROchr12:12332744chr12:15733631ENST00000442921815532_628188.0723.6666666666666DomainFibronectin type-III 6
TgenePTPROchr12:12332744chr12:15733631ENST00000442921815631_724188.0723.6666666666666DomainFibronectin type-III 7
TgenePTPROchr12:12332744chr12:15733631ENST00000442921815725_817188.0723.6666666666666DomainFibronectin type-III 8
TgenePTPROchr12:12332744chr12:15733631ENST00000442921815938_1195188.0723.6666666666666DomainTyrosine-protein phosphatase
TgenePTPROchr12:12332744chr12:15733631ENST00000445537814246_306188.0406.0DomainFibronectin type-III 3
TgenePTPROchr12:12332744chr12:15733631ENST00000445537814329_425188.0406.0DomainFibronectin type-III 4
TgenePTPROchr12:12332744chr12:15733631ENST00000445537814435_531188.0406.0DomainFibronectin type-III 5
TgenePTPROchr12:12332744chr12:15733631ENST00000445537814532_628188.0406.0DomainFibronectin type-III 6
TgenePTPROchr12:12332744chr12:15733631ENST00000445537814631_724188.0406.0DomainFibronectin type-III 7
TgenePTPROchr12:12332744chr12:15733631ENST00000445537814725_817188.0406.0DomainFibronectin type-III 8
TgenePTPROchr12:12332744chr12:15733631ENST00000445537814938_1195188.0406.0DomainTyrosine-protein phosphatase
TgenePTPROchr12:12332744chr12:15733631ENST00000542557714246_306160.0695.6666666666666DomainFibronectin type-III 3
TgenePTPROchr12:12332744chr12:15733631ENST00000542557714329_425160.0695.6666666666666DomainFibronectin type-III 4
TgenePTPROchr12:12332744chr12:15733631ENST00000542557714435_531160.0695.6666666666666DomainFibronectin type-III 5
TgenePTPROchr12:12332744chr12:15733631ENST00000542557714532_628160.0695.6666666666666DomainFibronectin type-III 6
TgenePTPROchr12:12332744chr12:15733631ENST00000542557714631_724160.0695.6666666666666DomainFibronectin type-III 7
TgenePTPROchr12:12332744chr12:15733631ENST00000542557714725_817160.0695.6666666666666DomainFibronectin type-III 8
TgenePTPROchr12:12332744chr12:15733631ENST00000542557714938_1195160.0695.6666666666666DomainTyrosine-protein phosphatase
TgenePTPROchr12:12332744chr12:15733631ENST00000544244713246_306160.0378.0DomainFibronectin type-III 3
TgenePTPROchr12:12332744chr12:15733631ENST00000544244713329_425160.0378.0DomainFibronectin type-III 4
TgenePTPROchr12:12332744chr12:15733631ENST00000544244713435_531160.0378.0DomainFibronectin type-III 5
TgenePTPROchr12:12332744chr12:15733631ENST00000544244713532_628160.0378.0DomainFibronectin type-III 6
TgenePTPROchr12:12332744chr12:15733631ENST00000544244713631_724160.0378.0DomainFibronectin type-III 7
TgenePTPROchr12:12332744chr12:15733631ENST00000544244713725_817160.0378.0DomainFibronectin type-III 8
TgenePTPROchr12:12332744chr12:15733631ENST00000544244713938_1195160.0378.0DomainTyrosine-protein phosphatase
TgenePTPROchr12:12332743chr12:15733630ENST0000028117120271136_1142999.01516.6666666666667RegionSubstrate binding
TgenePTPROchr12:12332743chr12:15733630ENST0000034896219261136_1142971.01540.6666666666667RegionSubstrate binding
TgenePTPROchr12:12332743chr12:15733630ENST000004429218151136_1142188.0723.6666666666666RegionSubstrate binding
TgenePTPROchr12:12332743chr12:15733630ENST000004455378141136_1142188.0406.0RegionSubstrate binding
TgenePTPROchr12:12332743chr12:15733630ENST000005425577141136_1142160.0695.6666666666666RegionSubstrate binding
TgenePTPROchr12:12332743chr12:15733630ENST000005442447131136_1142160.0378.0RegionSubstrate binding
TgenePTPROchr12:12332744chr12:15733631ENST0000028117120271136_1142999.01516.6666666666667RegionSubstrate binding
TgenePTPROchr12:12332744chr12:15733631ENST0000034896219261136_1142971.01540.6666666666667RegionSubstrate binding
TgenePTPROchr12:12332744chr12:15733631ENST000004429218151136_1142188.0723.6666666666666RegionSubstrate binding
TgenePTPROchr12:12332744chr12:15733631ENST000004455378141136_1142188.0406.0RegionSubstrate binding
TgenePTPROchr12:12332744chr12:15733631ENST000005425577141136_1142160.0695.6666666666666RegionSubstrate binding
TgenePTPROchr12:12332744chr12:15733631ENST000005442447131136_1142160.0378.0RegionSubstrate binding
TgenePTPROchr12:12332743chr12:15733630ENST00000442921815844_1216188.0723.6666666666666Topological domainCytoplasmic
TgenePTPROchr12:12332743chr12:15733630ENST00000445537814844_1216188.0406.0Topological domainCytoplasmic
TgenePTPROchr12:12332743chr12:15733630ENST00000542557714844_1216160.0695.6666666666666Topological domainCytoplasmic
TgenePTPROchr12:12332743chr12:15733630ENST00000544244713844_1216160.0378.0Topological domainCytoplasmic
TgenePTPROchr12:12332744chr12:15733631ENST00000442921815844_1216188.0723.6666666666666Topological domainCytoplasmic
TgenePTPROchr12:12332744chr12:15733631ENST00000445537814844_1216188.0406.0Topological domainCytoplasmic
TgenePTPROchr12:12332744chr12:15733631ENST00000542557714844_1216160.0695.6666666666666Topological domainCytoplasmic
TgenePTPROchr12:12332744chr12:15733631ENST00000544244713844_1216160.0378.0Topological domainCytoplasmic
TgenePTPROchr12:12332743chr12:15733630ENST00000442921815823_843188.0723.6666666666666TransmembraneHelical
TgenePTPROchr12:12332743chr12:15733630ENST00000445537814823_843188.0406.0TransmembraneHelical
TgenePTPROchr12:12332743chr12:15733630ENST00000542557714823_843160.0695.6666666666666TransmembraneHelical
TgenePTPROchr12:12332743chr12:15733630ENST00000544244713823_843160.0378.0TransmembraneHelical
TgenePTPROchr12:12332744chr12:15733631ENST00000442921815823_843188.0723.6666666666666TransmembraneHelical
TgenePTPROchr12:12332744chr12:15733631ENST00000445537814823_843188.0406.0TransmembraneHelical
TgenePTPROchr12:12332744chr12:15733631ENST00000542557714823_843160.0695.6666666666666TransmembraneHelical
TgenePTPROchr12:12332744chr12:15733631ENST00000544244713823_843160.0378.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-7231203_1244515.01614.0DomainNote=EGF-like 4
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-7231248_1286515.01614.0DomainLDL-receptor class A 1
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-7231287_1323515.01614.0DomainLDL-receptor class A 2
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-7231325_1361515.01614.0DomainLDL-receptor class A 3
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-723588_628515.01614.0DomainNote=EGF-like 2
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-723889_930515.01614.0DomainNote=EGF-like 3
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-7231203_1244515.01614.0DomainNote=EGF-like 4
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-7231248_1286515.01614.0DomainLDL-receptor class A 1
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-7231287_1323515.01614.0DomainLDL-receptor class A 2
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-7231325_1361515.01614.0DomainLDL-receptor class A 3
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-723588_628515.01614.0DomainNote=EGF-like 2
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-723889_930515.01614.0DomainNote=EGF-like 3
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-7231487_1493515.01614.0MotifNote=PPPSP motif A
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-7231527_1534515.01614.0MotifNote=PPPSP motif B
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-7231568_1575515.01614.0MotifNote=PPPSP motif C
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-7231588_1593515.01614.0MotifNote=PPPSP motif D
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-7231603_1610515.01614.0MotifNote=PPPSP motif E
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-7231487_1493515.01614.0MotifNote=PPPSP motif A
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-7231527_1534515.01614.0MotifNote=PPPSP motif B
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-7231568_1575515.01614.0MotifNote=PPPSP motif C
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-7231588_1593515.01614.0MotifNote=PPPSP motif D
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-7231603_1610515.01614.0MotifNote=PPPSP motif E
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-723328_589515.01614.0RegionNote=Beta-propeller 2
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-723631_890515.01614.0RegionNote=Beta-propeller 3
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-723933_1202515.01614.0RegionNote=Beta-propeller 4
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-723328_589515.01614.0RegionNote=Beta-propeller 2
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-723631_890515.01614.0RegionNote=Beta-propeller 3
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-723933_1202515.01614.0RegionNote=Beta-propeller 4
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-7231026_1068515.01614.0RepeatNote=LDL-receptor class B 17
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-7231069_1113515.01614.0RepeatNote=LDL-receptor class B 18
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-7231114_1156515.01614.0RepeatNote=LDL-receptor class B 19
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-7231157_1198515.01614.0RepeatNote=LDL-receptor class B 20
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-723502_542515.01614.0RepeatNote=LDL-receptor class B 9
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-723543_584515.01614.0RepeatNote=LDL-receptor class B 10
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-723674_716515.01614.0RepeatNote=LDL-receptor class B 11
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-723717_759515.01614.0RepeatNote=LDL-receptor class B 12
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-723760_802515.01614.0RepeatNote=LDL-receptor class B 13
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-723803_842515.01614.0RepeatNote=LDL-receptor class B 14
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-723843_885515.01614.0RepeatNote=LDL-receptor class B 15
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-723977_1025515.01614.0RepeatNote=LDL-receptor class B 16
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-7231026_1068515.01614.0RepeatNote=LDL-receptor class B 17
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-7231069_1113515.01614.0RepeatNote=LDL-receptor class B 18
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-7231114_1156515.01614.0RepeatNote=LDL-receptor class B 19
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-7231157_1198515.01614.0RepeatNote=LDL-receptor class B 20
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-723502_542515.01614.0RepeatNote=LDL-receptor class B 9
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-723543_584515.01614.0RepeatNote=LDL-receptor class B 10
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-723674_716515.01614.0RepeatNote=LDL-receptor class B 11
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-723717_759515.01614.0RepeatNote=LDL-receptor class B 12
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-723760_802515.01614.0RepeatNote=LDL-receptor class B 13
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-723803_842515.01614.0RepeatNote=LDL-receptor class B 14
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-723843_885515.01614.0RepeatNote=LDL-receptor class B 15
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-723977_1025515.01614.0RepeatNote=LDL-receptor class B 16
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-7231394_1613515.01614.0Topological domainCytoplasmic
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-72320_1370515.01614.0Topological domainExtracellular
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-7231394_1613515.01614.0Topological domainCytoplasmic
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-72320_1370515.01614.0Topological domainExtracellular
HgeneLRP6chr12:12332743chr12:15733630ENST00000261349-7231371_1393515.01614.0TransmembraneHelical
HgeneLRP6chr12:12332744chr12:15733631ENST00000261349-7231371_1393515.01614.0TransmembraneHelical
TgenePTPROchr12:12332743chr12:15733630ENST000002811712027142_211999.01516.6666666666667DomainFibronectin type-III 2
TgenePTPROchr12:12332743chr12:15733630ENST000002811712027246_306999.01516.6666666666667DomainFibronectin type-III 3
TgenePTPROchr12:12332743chr12:15733630ENST000002811712027329_425999.01516.6666666666667DomainFibronectin type-III 4
TgenePTPROchr12:12332743chr12:15733630ENST000002811712027435_531999.01516.6666666666667DomainFibronectin type-III 5
TgenePTPROchr12:12332743chr12:15733630ENST00000281171202750_124999.01516.6666666666667DomainFibronectin type-III 1
TgenePTPROchr12:12332743chr12:15733630ENST000002811712027532_628999.01516.6666666666667DomainFibronectin type-III 6
TgenePTPROchr12:12332743chr12:15733630ENST000002811712027631_724999.01516.6666666666667DomainFibronectin type-III 7
TgenePTPROchr12:12332743chr12:15733630ENST000002811712027725_817999.01516.6666666666667DomainFibronectin type-III 8
TgenePTPROchr12:12332743chr12:15733630ENST000002811712027938_1195999.01516.6666666666667DomainTyrosine-protein phosphatase
TgenePTPROchr12:12332743chr12:15733630ENST000003489621926142_211971.01540.6666666666667DomainFibronectin type-III 2
TgenePTPROchr12:12332743chr12:15733630ENST000003489621926246_306971.01540.6666666666667DomainFibronectin type-III 3
TgenePTPROchr12:12332743chr12:15733630ENST000003489621926329_425971.01540.6666666666667DomainFibronectin type-III 4
TgenePTPROchr12:12332743chr12:15733630ENST000003489621926435_531971.01540.6666666666667DomainFibronectin type-III 5
TgenePTPROchr12:12332743chr12:15733630ENST00000348962192650_124971.01540.6666666666667DomainFibronectin type-III 1
TgenePTPROchr12:12332743chr12:15733630ENST000003489621926532_628971.01540.6666666666667DomainFibronectin type-III 6
TgenePTPROchr12:12332743chr12:15733630ENST000003489621926631_724971.01540.6666666666667DomainFibronectin type-III 7
TgenePTPROchr12:12332743chr12:15733630ENST000003489621926725_817971.01540.6666666666667DomainFibronectin type-III 8
TgenePTPROchr12:12332743chr12:15733630ENST000003489621926938_1195971.01540.6666666666667DomainTyrosine-protein phosphatase
TgenePTPROchr12:12332743chr12:15733630ENST00000442921815142_211188.0723.6666666666666DomainFibronectin type-III 2
TgenePTPROchr12:12332743chr12:15733630ENST0000044292181550_124188.0723.6666666666666DomainFibronectin type-III 1
TgenePTPROchr12:12332743chr12:15733630ENST00000445537814142_211188.0406.0DomainFibronectin type-III 2
TgenePTPROchr12:12332743chr12:15733630ENST0000044553781450_124188.0406.0DomainFibronectin type-III 1
TgenePTPROchr12:12332743chr12:15733630ENST00000542557714142_211160.0695.6666666666666DomainFibronectin type-III 2
TgenePTPROchr12:12332743chr12:15733630ENST0000054255771450_124160.0695.6666666666666DomainFibronectin type-III 1
TgenePTPROchr12:12332743chr12:15733630ENST00000544244713142_211160.0378.0DomainFibronectin type-III 2
TgenePTPROchr12:12332743chr12:15733630ENST0000054424471350_124160.0378.0DomainFibronectin type-III 1
TgenePTPROchr12:12332744chr12:15733631ENST000002811712027142_211999.01516.6666666666667DomainFibronectin type-III 2
TgenePTPROchr12:12332744chr12:15733631ENST000002811712027246_306999.01516.6666666666667DomainFibronectin type-III 3
TgenePTPROchr12:12332744chr12:15733631ENST000002811712027329_425999.01516.6666666666667DomainFibronectin type-III 4
TgenePTPROchr12:12332744chr12:15733631ENST000002811712027435_531999.01516.6666666666667DomainFibronectin type-III 5
TgenePTPROchr12:12332744chr12:15733631ENST00000281171202750_124999.01516.6666666666667DomainFibronectin type-III 1
TgenePTPROchr12:12332744chr12:15733631ENST000002811712027532_628999.01516.6666666666667DomainFibronectin type-III 6
TgenePTPROchr12:12332744chr12:15733631ENST000002811712027631_724999.01516.6666666666667DomainFibronectin type-III 7
TgenePTPROchr12:12332744chr12:15733631ENST000002811712027725_817999.01516.6666666666667DomainFibronectin type-III 8
TgenePTPROchr12:12332744chr12:15733631ENST000002811712027938_1195999.01516.6666666666667DomainTyrosine-protein phosphatase
TgenePTPROchr12:12332744chr12:15733631ENST000003489621926142_211971.01540.6666666666667DomainFibronectin type-III 2
TgenePTPROchr12:12332744chr12:15733631ENST000003489621926246_306971.01540.6666666666667DomainFibronectin type-III 3
TgenePTPROchr12:12332744chr12:15733631ENST000003489621926329_425971.01540.6666666666667DomainFibronectin type-III 4
TgenePTPROchr12:12332744chr12:15733631ENST000003489621926435_531971.01540.6666666666667DomainFibronectin type-III 5
TgenePTPROchr12:12332744chr12:15733631ENST00000348962192650_124971.01540.6666666666667DomainFibronectin type-III 1
TgenePTPROchr12:12332744chr12:15733631ENST000003489621926532_628971.01540.6666666666667DomainFibronectin type-III 6
TgenePTPROchr12:12332744chr12:15733631ENST000003489621926631_724971.01540.6666666666667DomainFibronectin type-III 7
TgenePTPROchr12:12332744chr12:15733631ENST000003489621926725_817971.01540.6666666666667DomainFibronectin type-III 8
TgenePTPROchr12:12332744chr12:15733631ENST000003489621926938_1195971.01540.6666666666667DomainTyrosine-protein phosphatase
TgenePTPROchr12:12332744chr12:15733631ENST00000442921815142_211188.0723.6666666666666DomainFibronectin type-III 2
TgenePTPROchr12:12332744chr12:15733631ENST0000044292181550_124188.0723.6666666666666DomainFibronectin type-III 1
TgenePTPROchr12:12332744chr12:15733631ENST00000445537814142_211188.0406.0DomainFibronectin type-III 2
TgenePTPROchr12:12332744chr12:15733631ENST0000044553781450_124188.0406.0DomainFibronectin type-III 1
TgenePTPROchr12:12332744chr12:15733631ENST00000542557714142_211160.0695.6666666666666DomainFibronectin type-III 2
TgenePTPROchr12:12332744chr12:15733631ENST0000054255771450_124160.0695.6666666666666DomainFibronectin type-III 1
TgenePTPROchr12:12332744chr12:15733631ENST00000544244713142_211160.0378.0DomainFibronectin type-III 2
TgenePTPROchr12:12332744chr12:15733631ENST0000054424471350_124160.0378.0DomainFibronectin type-III 1
TgenePTPROchr12:12332743chr12:15733630ENST00000281171202730_822999.01516.6666666666667Topological domainExtracellular
TgenePTPROchr12:12332743chr12:15733630ENST000002811712027844_1216999.01516.6666666666667Topological domainCytoplasmic
TgenePTPROchr12:12332743chr12:15733630ENST00000348962192630_822971.01540.6666666666667Topological domainExtracellular
TgenePTPROchr12:12332743chr12:15733630ENST000003489621926844_1216971.01540.6666666666667Topological domainCytoplasmic
TgenePTPROchr12:12332743chr12:15733630ENST0000044292181530_822188.0723.6666666666666Topological domainExtracellular
TgenePTPROchr12:12332743chr12:15733630ENST0000044553781430_822188.0406.0Topological domainExtracellular
TgenePTPROchr12:12332743chr12:15733630ENST0000054255771430_822160.0695.6666666666666Topological domainExtracellular
TgenePTPROchr12:12332743chr12:15733630ENST0000054424471330_822160.0378.0Topological domainExtracellular
TgenePTPROchr12:12332744chr12:15733631ENST00000281171202730_822999.01516.6666666666667Topological domainExtracellular
TgenePTPROchr12:12332744chr12:15733631ENST000002811712027844_1216999.01516.6666666666667Topological domainCytoplasmic
TgenePTPROchr12:12332744chr12:15733631ENST00000348962192630_822971.01540.6666666666667Topological domainExtracellular
TgenePTPROchr12:12332744chr12:15733631ENST000003489621926844_1216971.01540.6666666666667Topological domainCytoplasmic
TgenePTPROchr12:12332744chr12:15733631ENST0000044292181530_822188.0723.6666666666666Topological domainExtracellular
TgenePTPROchr12:12332744chr12:15733631ENST0000044553781430_822188.0406.0Topological domainExtracellular
TgenePTPROchr12:12332744chr12:15733631ENST0000054255771430_822160.0695.6666666666666Topological domainExtracellular
TgenePTPROchr12:12332744chr12:15733631ENST0000054424471330_822160.0378.0Topological domainExtracellular
TgenePTPROchr12:12332743chr12:15733630ENST000002811712027823_843999.01516.6666666666667TransmembraneHelical
TgenePTPROchr12:12332743chr12:15733630ENST000003489621926823_843971.01540.6666666666667TransmembraneHelical
TgenePTPROchr12:12332744chr12:15733631ENST000002811712027823_843999.01516.6666666666667TransmembraneHelical
TgenePTPROchr12:12332744chr12:15733631ENST000003489621926823_843971.01540.6666666666667TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
LRP6_pLDDT.png
all structure
all structure
PTPRO_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
LRP6
PTPRO


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to LRP6-PTPRO


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to LRP6-PTPRO


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource