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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:MDM2-BRI3BP

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: MDM2-BRI3BP
FusionPDB ID: 52391
FusionGDB2.0 ID: 52391
HgeneTgene
Gene symbol

MDM2

BRI3BP

Gene ID

4193

140707

Gene nameMDM2 proto-oncogeneBRI3 binding protein
SynonymsACTFS|HDMX|LSKB|hdm2BNAS1|HCCR-1|HCCR-2|HCCRBP-1|HCCRBP-3|KG19
Cytomap

12q15

12q24.31

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase Mdm2MDM2 oncogene, E3 ubiquitin protein ligaseMDM2 proto-oncogene, E3 ubiquitin protein ligaseMdm2, p53 E3 ubiquitin protein ligase homologMdm2, transformed 3T3 cell double minute 2, p53 binding proteindouble minute 2, humBRI3-binding proteinI3-binding proteincervical cancer 1 proto-oncogene-binding protein KG19cervical cancer oncogene binding protein
Modification date2020032920200313
UniProtAcc

Q00987

Q8WY22

Ensembl transtripts involved in fusion geneENST idsENST00000478070, ENST00000258148, 
ENST00000258149, ENST00000350057, 
ENST00000462284, ENST00000299252, 
ENST00000348801, ENST00000356290, 
ENST00000360430, ENST00000393410, 
ENST00000393412, ENST00000393413, 
ENST00000428863, ENST00000517852, 
ENST00000540827, ENST00000544125, 
ENST00000544561, ENST00000545204, 
ENST00000341446, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score39 X 20 X 11=85808 X 8 X 4=256
# samples 479
** MAII scorelog2(47/8580*10)=-4.19024498582191
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/256*10)=-1.50814690367033
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: MDM2 [Title/Abstract] AND BRI3BP [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)MDM2(69214154)-BRI3BP(125509890), # samples:2
Anticipated loss of major functional domain due to fusion event.MDM2-BRI3BP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MDM2-BRI3BP seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MDM2-BRI3BP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MDM2-BRI3BP seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
MDM2-BRI3BP seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
MDM2-BRI3BP seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneMDM2

GO:0000122

negative regulation of transcription by RNA polymerase II

9271120|17310983

HgeneMDM2

GO:0006511

ubiquitin-dependent protein catabolic process

11278372|15314173|16173922|17310983

HgeneMDM2

GO:0016567

protein ubiquitination

9450543|15878855|19656744|20153724

HgeneMDM2

GO:0031648

protein destabilization

9529249|10360174|15314173

HgeneMDM2

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

11278372

HgeneMDM2

GO:0034504

protein localization to nucleus

10360174

HgeneMDM2

GO:0042176

regulation of protein catabolic process

9153395

HgeneMDM2

GO:0043518

negative regulation of DNA damage response, signal transduction by p53 class mediator

9529249|10360174

HgeneMDM2

GO:0045184

establishment of protein localization

10360174

HgeneMDM2

GO:0045892

negative regulation of transcription, DNA-templated

9271120

HgeneMDM2

GO:0065003

protein-containing complex assembly

10608892|12915590

HgeneMDM2

GO:0071157

negative regulation of cell cycle arrest

9529249

HgeneMDM2

GO:0071480

cellular response to gamma radiation

16213212

HgeneMDM2

GO:0072717

cellular response to actinomycin D

15314173

HgeneMDM2

GO:1901797

negative regulation of signal transduction by p53 class mediator

16173922


check buttonFusion gene breakpoints across MDM2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BRI3BP (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-KK-A7B2-01AMDM2chr12

69214154

+BRI3BPchr12

125509890

+
ChimerDB4PRADTCGA-KK-A7B2MDM2chr12

69214154

+BRI3BPchr12

125509890

+
ChimerDB4PRADTCGA-KK-A7B2MDM2chr12

69216191

+BRI3BPchr12

125509884

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000462284MDM2chr1269214154+ENST00000341446BRI3BPchr12125509890+6547660266745159
ENST00000258149MDM2chr1269214154+ENST00000341446BRI3BPchr12125509890+6532645251730159
ENST00000258148MDM2chr1269214154+ENST00000341446BRI3BPchr12125509890+625937214457147
ENST00000350057MDM2chr1269214154+ENST00000341446BRI3BPchr12125509890+615226525912232119

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000462284ENST00000341446MDM2chr1269214154+BRI3BPchr12125509890+0.0065610650.9934389
ENST00000258149ENST00000341446MDM2chr1269214154+BRI3BPchr12125509890+0.0064666440.9935334
ENST00000258148ENST00000341446MDM2chr1269214154+BRI3BPchr12125509890+0.0056071270.9943929
ENST00000350057ENST00000341446MDM2chr1269214154+BRI3BPchr12125509890+0.0210229160.9789771

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>52391_52391_1_MDM2-BRI3BP_MDM2_chr12_69214154_ENST00000258148_BRI3BP_chr12_125509890_ENST00000341446_length(amino acids)=147AA_BP=120
MVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQHIVYCSNDLLGD

--------------------------------------------------------------

>52391_52391_2_MDM2-BRI3BP_MDM2_chr12_69214154_ENST00000258149_BRI3BP_chr12_125509890_ENST00000341446_length(amino acids)=159AA_BP=132
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQ

--------------------------------------------------------------

>52391_52391_3_MDM2-BRI3BP_MDM2_chr12_69214154_ENST00000350057_BRI3BP_chr12_125509890_ENST00000341446_length(amino acids)=119AA_BP=
MRRSLTLLLRLECGGMISADCNLRLPCSSDSPASASQVAGITGAHHQAWLIFVFLVETGFHSVGRAGLKLLTSGDPPALASQSVGIIGVS

--------------------------------------------------------------

>52391_52391_4_MDM2-BRI3BP_MDM2_chr12_69214154_ENST00000462284_BRI3BP_chr12_125509890_ENST00000341446_length(amino acids)=159AA_BP=132
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQ

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:69214154/chr12:125509890)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
MDM2

Q00987

BRI3BP

Q8WY22

FUNCTION: E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as a ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways. Mediates ubiquitination and subsequent proteasome degradation of DYRK2 in nucleus. Ubiquitinates IGF1R and SNAI1 and promotes them to proteasomal degradation (PubMed:12821780, PubMed:15053880, PubMed:15195100, PubMed:15632057, PubMed:16337594, PubMed:17290220, PubMed:19098711, PubMed:19219073, PubMed:19837670, PubMed:19965871, PubMed:20173098, PubMed:20385133, PubMed:20858735, PubMed:22128911). Ubiquitinates DCX, leading to DCX degradation and reduction of the dendritic spine density of olfactory bulb granule cells (By similarity). Ubiquitinates DLG4, leading to proteasomal degradation of DLG4 which is required for AMPA receptor endocytosis (By similarity). Negatively regulates NDUFS1, leading to decreased mitochondrial respiration, marked oxidative stress, and commitment to the mitochondrial pathway of apoptosis (PubMed:30879903). Binds NDUFS1 leading to its cytosolic retention rather than mitochondrial localization resulting in decreased supercomplex assembly (interactions between complex I and complex III), decreased complex I activity, ROS production, and apoptosis (PubMed:30879903). {ECO:0000250|UniProtKB:P23804, ECO:0000269|PubMed:12821780, ECO:0000269|PubMed:15053880, ECO:0000269|PubMed:15195100, ECO:0000269|PubMed:15632057, ECO:0000269|PubMed:16337594, ECO:0000269|PubMed:17290220, ECO:0000269|PubMed:19098711, ECO:0000269|PubMed:19219073, ECO:0000269|PubMed:19837670, ECO:0000269|PubMed:19965871, ECO:0000269|PubMed:20173098, ECO:0000269|PubMed:20385133, ECO:0000269|PubMed:20858735, ECO:0000269|PubMed:22128911, ECO:0000269|PubMed:30879903}.FUNCTION: Involved in tumorigenesis and may function by stabilizing p53/TP53. {ECO:0000269|PubMed:17943721}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+5926_109113.33333333333333437.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+51126_109119.33333333333333498.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+591_101113.33333333333333437.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+5111_101119.33333333333333498.0RegionSufficient to promote the mitochondrial pathway of apoptosis
TgeneBRI3BPchr12:69214154chr12:125509890ENST0000034144603217_2470252.0Coiled coilOntology_term=ECO:0000255
TgeneBRI3BPchr12:69214154chr12:125509890ENST0000034144603125_1450252.0TransmembraneHelical
TgeneBRI3BPchr12:69214154chr12:125509890ENST000003414460313_330252.0TransmembraneHelical
TgeneBRI3BPchr12:69214154chr12:125509890ENST0000034144603146_1660252.0TransmembraneHelical
TgeneBRI3BPchr12:69214154chr12:125509890ENST0000034144603185_2050252.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59210_215113.33333333333333437.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59243_301113.33333333333333437.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15210_2150.0322.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15243_3010.0322.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13210_2150.0266.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13243_3010.0266.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16210_2150322.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16243_3010322.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14210_2150.0297.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14243_3010.0297.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13210_2150219.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13243_3010219.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12210_2150.0219.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12243_3010.0219.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14210_2150271.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14243_3010271.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511210_215119.33333333333333498.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511243_301119.33333333333333498.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15210_2150297.0Compositional biasNote=Poly-Ser
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15243_3010297.0Compositional biasNote=Asp/Glu-rich (acidic)
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+1526_1090.0322.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+1326_1090.0266.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+1626_1090322.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+1426_1090.0297.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+1326_1090219.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+1226_1090.0219.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+1426_1090271.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+1526_1090297.0DomainSWIB/MDM2
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59179_185113.33333333333333437.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59190_202113.33333333333333437.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59466_473113.33333333333333437.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15179_1850.0322.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15190_2020.0322.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15466_4730.0322.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13179_1850.0266.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13190_2020.0266.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13466_4730.0266.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16179_1850322.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16190_2020322.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16466_4730322.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14179_1850.0297.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14190_2020.0297.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14466_4730.0297.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13179_1850219.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13190_2020219.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13466_4730219.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12179_1850.0219.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12190_2020.0219.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12466_4730.0219.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14179_1850271.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14190_2020271.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14466_4730271.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511179_185119.33333333333333498.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511190_202119.33333333333333498.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511466_473119.33333333333333498.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15179_1850297.0MotifNuclear localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15190_2020297.0MotifNote=Nuclear export signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15466_4730297.0MotifNucleolar localization signal
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59210_304113.33333333333333437.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59242_331113.33333333333333437.0RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+151_1010.0322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15210_3040.0322.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15242_3310.0322.0RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+131_1010.0266.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13210_3040.0266.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13242_3310.0266.0RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+161_1010322.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16210_3040322.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16242_3310322.0RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+141_1010.0297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14210_3040.0297.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14242_3310.0297.0RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+131_1010219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13210_3040219.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13242_3310219.0RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+121_1010.0219.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12210_3040.0219.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12242_3310.0219.0RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+141_1010271.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14210_3040271.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14242_3310271.0RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511210_304119.33333333333333498.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511242_331119.33333333333333498.0RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+151_1010297.0RegionSufficient to promote the mitochondrial pathway of apoptosis
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15210_3040297.0RegionNote=ARF-binding
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15242_3310297.0RegionNote=Region II
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59299_328113.33333333333333437.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59438_479113.33333333333333437.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15299_3280.0322.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15438_4790.0322.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13299_3280.0266.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13438_4790.0266.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16299_3280322.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16438_4790322.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14299_3280.0297.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14438_4790.0297.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13299_3280219.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13438_4790219.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12299_3280.0219.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12438_4790.0219.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14299_3280271.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14438_4790271.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511299_328119.33333333333333498.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511438_479119.33333333333333498.0Zinc fingerRING-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15299_3280297.0Zinc fingerRanBP2-type
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15438_4790297.0Zinc fingerRING-type


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>148_MDM2_69214154_BRI3BP_125509890_ranked_0.pdbMDM26921415469214154ENST00000341446BRI3BPchr12125509890+
MRDPRLQARKPRMVRSRQMCNTNMSVPTDGAVTTSQIPASEQETLVRPKPLLLKLLKSVGAQKDTYTMKEVLFYLGQYIMTKRLYDEKQQ
159


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
MDM2_pLDDT.png
all structure
all structure
BRI3BP_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
MDM2
BRI3BP


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59170_306113.33333333333333437.0MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15170_3060.0322.0MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13170_3060.0266.0MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16170_3060322.0MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14170_3060.0297.0MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13170_3060219.0MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12170_3060.0219.0MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14170_3060271.0MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511170_306119.33333333333333498.0MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15170_3060297.0MTBP
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59150_230113.33333333333333437.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15150_2300.0322.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13150_2300.0266.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16150_2300322.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14150_2300.0297.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13150_2300219.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12150_2300.0219.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14150_2300271.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511150_230119.33333333333333498.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15150_2300297.0PYHIN1 and necessary for interaction with RFFL and RNF34
HgeneMDM2chr12:69214154chr12:125509890ENST00000258149+59223_232113.33333333333333437.0USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000299252+15223_2320.0322.0USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000348801+13223_2320.0266.0USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000356290+16223_2320322.0USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000360430+14223_2320.0297.0USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000393412+13223_2320219.0USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000393413+12223_2320.0219.0USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000428863+14223_2320271.0USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000462284+511223_232119.33333333333333498.0USP7
HgeneMDM2chr12:69214154chr12:125509890ENST00000540827+15223_2320297.0USP7


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Related Drugs to MDM2-BRI3BP


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to MDM2-BRI3BP


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource