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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:NADSYN1-SPAG9

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: NADSYN1-SPAG9
	FusionPDB ID: 57135
	FusionGDB2.0 ID: 57135
		Hgene	Tgene
	Gene symbol	NADSYN1	SPAG9
	Gene ID	55191	9043
	Gene name	NAD synthetase 1	sperm associated antigen 9
	Synonyms	-	CT89\|HLC-6\|HLC4\|HLC6\|JIP-4\|JIP4\|JLP\|PHET\|PIG6
	Cytomap	11q13.4	17q21.33
	Type of gene	protein-coding	protein-coding
	Description	glutamine-dependent NAD(+) synthetaseNAD(+) synthaseNAD(+) synthetaseglutamine-dependent NAD synthetase	C-Jun-amino-terminal kinase-interacting protein 4JNK interacting proteinJNK/SAPK-associated proteinMax-binding proteinc-Jun NH2-terminal kinase-associated leucine zipper proteincancer/testis antigen 89human lung cancer oncogene 6 proteinlung cancer
	Modification date	20200313	20200315
	UniProtAcc	Q6IA69	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000526039, ENST00000319023, ENST00000530055, ENST00000539574,	ENST00000262013, ENST00000357122, ENST00000505279, ENST00000509724, ENST00000510283,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	14 X 13 X 7=1274	15 X 14 X 6=1260
	# samples	17	16
	** MAII score	log2(17/1274*10)=-2.9057586261186 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/1260*10)=-2.97727992349992 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: NADSYN1 [Title/Abstract] AND SPAG9 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	NADSYN1(71193071)-SPAG9(49048217), # samples:3
Anticipated loss of major functional domain due to fusion event.	NADSYN1-SPAG9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NADSYN1-SPAG9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. NADSYN1-SPAG9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. NADSYN1-SPAG9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	SPAG9	GO:0042147	retrograde transport, endosome to Golgi	19056739

Fusion gene breakpoints across NADSYN1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across SPAG9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	ESCA	TCGA-L5-A43I-01A	NADSYN1	chr11	71193071	-	SPAG9	chr17	49048217	-
ChimerDB4	ESCA	TCGA-L5-A43I-01A	NADSYN1	chr11	71193071	+	SPAG9	chr17	49048217	-
ChimerDB4	ESCA	TCGA-L5-A43I	NADSYN1	chr11	71193071	+	SPAG9	chr17	49048217	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000319023	NADSYN1	chr11	71193071	+	ENST00000262013	SPAG9	chr17	49048217	-	5702	1338	188	1603	471
ENST00000319023	NADSYN1	chr11	71193071	+	ENST00000505279	SPAG9	chr17	49048217	-	2249	1338	188	1603	471
ENST00000319023	NADSYN1	chr11	71193071	+	ENST00000357122	SPAG9	chr17	49048217	-	2232	1338	188	1603	471
ENST00000539574	NADSYN1	chr11	71193071	+	ENST00000262013	SPAG9	chr17	49048217	-	5516	1152	782	1417	211
ENST00000539574	NADSYN1	chr11	71193071	+	ENST00000505279	SPAG9	chr17	49048217	-	2063	1152	782	1417	211
ENST00000539574	NADSYN1	chr11	71193071	+	ENST00000357122	SPAG9	chr17	49048217	-	2046	1152	782	1417	211
ENST00000530055	NADSYN1	chr11	71193071	+	ENST00000262013	SPAG9	chr17	49048217	-	5622	1258	127	924	265
ENST00000530055	NADSYN1	chr11	71193071	+	ENST00000505279	SPAG9	chr17	49048217	-	2169	1258	127	924	265
ENST00000530055	NADSYN1	chr11	71193071	+	ENST00000357122	SPAG9	chr17	49048217	-	2152	1258	127	924	265

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000319023	ENST00000262013	NADSYN1	chr11	71193071	+	SPAG9	chr17	49048217	-	0.000156936	0.999843
ENST00000319023	ENST00000505279	NADSYN1	chr11	71193071	+	SPAG9	chr17	49048217	-	0.000815479	0.99918455
ENST00000319023	ENST00000357122	NADSYN1	chr11	71193071	+	SPAG9	chr17	49048217	-	0.000821988	0.999178
ENST00000539574	ENST00000262013	NADSYN1	chr11	71193071	+	SPAG9	chr17	49048217	-	0.001336047	0.9986639
ENST00000539574	ENST00000505279	NADSYN1	chr11	71193071	+	SPAG9	chr17	49048217	-	0.004582287	0.9954177
ENST00000539574	ENST00000357122	NADSYN1	chr11	71193071	+	SPAG9	chr17	49048217	-	0.004690487	0.99530953
ENST00000530055	ENST00000262013	NADSYN1	chr11	71193071	+	SPAG9	chr17	49048217	-	0.08341157	0.9165884
ENST00000530055	ENST00000505279	NADSYN1	chr11	71193071	+	SPAG9	chr17	49048217	-	0.1200655	0.8799345
ENST00000530055	ENST00000357122	NADSYN1	chr11	71193071	+	SPAG9	chr17	49048217	-	0.123809114	0.8761909

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>57135_57135_1_NADSYN1-SPAG9_NADSYN1_chr11_71193071_ENST00000319023_SPAG9_chr17_49048217_ENST00000262013_length(amino acids)=471AA_BP=384
MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYESDTLLHSFQVLAALVESPVTQDIICDVGMPV
MHRNVRYNCRVIFLNRKILLIRPKMALANEGNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWT
PHSPHIDMGLDGVEIITNASGSHQVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRLYYDGCAMIAMNGSVFAQGSQFSLDDVEVLT
ATLDLEDVRSYRAEISSRNLAASRASPYPRVKVDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQAGFLLPLSGGV
DSAATACLIYSMCCQVCEAVRSGSQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLE

--------------------------------------------------------------

>57135_57135_2_NADSYN1-SPAG9_NADSYN1_chr11_71193071_ENST00000319023_SPAG9_chr17_49048217_ENST00000357122_length(amino acids)=471AA_BP=384
MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYESDTLLHSFQVLAALVESPVTQDIICDVGMPV
MHRNVRYNCRVIFLNRKILLIRPKMALANEGNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWT
PHSPHIDMGLDGVEIITNASGSHQVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRLYYDGCAMIAMNGSVFAQGSQFSLDDVEVLT
ATLDLEDVRSYRAEISSRNLAASRASPYPRVKVDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQAGFLLPLSGGV
DSAATACLIYSMCCQVCEAVRSGSQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLE

--------------------------------------------------------------

>57135_57135_3_NADSYN1-SPAG9_NADSYN1_chr11_71193071_ENST00000319023_SPAG9_chr17_49048217_ENST00000505279_length(amino acids)=471AA_BP=384
MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYESDTLLHSFQVLAALVESPVTQDIICDVGMPV
MHRNVRYNCRVIFLNRKILLIRPKMALANEGNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWT
PHSPHIDMGLDGVEIITNASGSHQVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRLYYDGCAMIAMNGSVFAQGSQFSLDDVEVLT
ATLDLEDVRSYRAEISSRNLAASRASPYPRVKVDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQAGFLLPLSGGV
DSAATACLIYSMCCQVCEAVRSGSQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLE

--------------------------------------------------------------

>57135_57135_4_NADSYN1-SPAG9_NADSYN1_chr11_71193071_ENST00000530055_SPAG9_chr17_49048217_ENST00000262013_length(amino acids)=265AA_BP=
MYLPYHPMYPFKHLIQWFFMYSWSYAATILAHFHYPKKKLYPLCTPFPSSGPGNHKSTVCLHGFAYSRRFIGMKSHSVWLPHFTVLLSRF
IYVLGAATPWYPQGLDPGACTDPLQGCLCPTVPPAKLTDMKSRPSVSMGFRSCDYCIFCLCAVESAGVEPTDTGSGCSLSLCMVRECSVA

--------------------------------------------------------------

>57135_57135_5_NADSYN1-SPAG9_NADSYN1_chr11_71193071_ENST00000530055_SPAG9_chr17_49048217_ENST00000357122_length(amino acids)=265AA_BP=
MYLPYHPMYPFKHLIQWFFMYSWSYAATILAHFHYPKKKLYPLCTPFPSSGPGNHKSTVCLHGFAYSRRFIGMKSHSVWLPHFTVLLSRF
IYVLGAATPWYPQGLDPGACTDPLQGCLCPTVPPAKLTDMKSRPSVSMGFRSCDYCIFCLCAVESAGVEPTDTGSGCSLSLCMVRECSVA

--------------------------------------------------------------

>57135_57135_6_NADSYN1-SPAG9_NADSYN1_chr11_71193071_ENST00000530055_SPAG9_chr17_49048217_ENST00000505279_length(amino acids)=265AA_BP=
MYLPYHPMYPFKHLIQWFFMYSWSYAATILAHFHYPKKKLYPLCTPFPSSGPGNHKSTVCLHGFAYSRRFIGMKSHSVWLPHFTVLLSRF
IYVLGAATPWYPQGLDPGACTDPLQGCLCPTVPPAKLTDMKSRPSVSMGFRSCDYCIFCLCAVESAGVEPTDTGSGCSLSLCMVRECSVA

--------------------------------------------------------------

>57135_57135_7_NADSYN1-SPAG9_NADSYN1_chr11_71193071_ENST00000539574_SPAG9_chr17_49048217_ENST00000262013_length(amino acids)=211AA_BP=124
MGISGQEVLTATLDLEDVRSYRAEISSRNLAASRASPYPRVKVDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQA
GFLLPLSGGVDSAATACLIYSMCCQVCEAVRSGSQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGGES

--------------------------------------------------------------

>57135_57135_8_NADSYN1-SPAG9_NADSYN1_chr11_71193071_ENST00000539574_SPAG9_chr17_49048217_ENST00000357122_length(amino acids)=211AA_BP=124
MGISGQEVLTATLDLEDVRSYRAEISSRNLAASRASPYPRVKVDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQA
GFLLPLSGGVDSAATACLIYSMCCQVCEAVRSGSQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGGES

--------------------------------------------------------------

>57135_57135_9_NADSYN1-SPAG9_NADSYN1_chr11_71193071_ENST00000539574_SPAG9_chr17_49048217_ENST00000505279_length(amino acids)=211AA_BP=124
MGISGQEVLTATLDLEDVRSYRAEISSRNLAASRASPYPRVKVDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQA
GFLLPLSGGVDSAATACLIYSMCCQVCEAVRSGSQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGGES

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:71193071/chr17:49048217)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
NADSYN1 Q6IA69	.
FUNCTION: Catalyzes the final step of the nicotinamide adenine dinucleotide (NAD) de novo synthesis pathway, the ATP-dependent amidation of deamido-NAD using L-glutamine as a nitrogen source. {ECO:0000269\|PubMed:12547821, ECO:0000269\|PubMed:31883644}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NADSYN1

chr11:71193071

chr17:49048217

ENST00000319023

5_275

383.3333333333333

707.0

Domain

CN hydrolase

Hgene

NADSYN1

chr11:71193071

chr17:49048217

ENST00000319023

355_362

383.3333333333333

707.0

Nucleotide binding

ATP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

NADSYN1

chr11:71193071

chr17:49048217

ENST00000319023

325_706

383.3333333333333

707.0

Region

Ligase

Tgene

SPAG9

chr11:71193071

chr17:49048217

ENST00000262013

408_534

1233.3333333333333

1322.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

SPAG9

chr11:71193071

chr17:49048217

ENST00000262013

66_166

1233.3333333333333

1322.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG9

chr11:71193071

chr17:49048217

ENST00000262013

724_758

1233.3333333333333

1322.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG9

chr11:71193071

chr17:49048217

ENST00000357122

408_534

1219.3333333333333

1308.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

SPAG9

chr11:71193071

chr17:49048217

ENST00000357122

66_166

1219.3333333333333

1308.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG9

chr11:71193071

chr17:49048217

ENST00000357122

724_758

1219.3333333333333

1308.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG9

chr11:71193071

chr17:49048217

ENST00000505279

408_534

1223.3333333333333

1312.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

SPAG9

chr11:71193071

chr17:49048217

ENST00000505279

66_166

1223.3333333333333

1312.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG9

chr11:71193071

chr17:49048217

ENST00000505279

724_758

1223.3333333333333

1312.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG9

chr11:71193071

chr17:49048217

ENST00000510283

408_534

1089.3333333333333

1178.0

Coiled coil

Ontology_term=ECO:0000269

Tgene

SPAG9

chr11:71193071

chr17:49048217

ENST00000510283

66_166

1089.3333333333333

1178.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG9

chr11:71193071

chr17:49048217

ENST00000510283

724_758

1089.3333333333333

1178.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

SPAG9

chr11:71193071

chr17:49048217

ENST00000262013

500_571

1233.3333333333333

1322.0

Domain

RH2

Tgene

SPAG9

chr11:71193071

chr17:49048217

ENST00000262013

7_95

1233.3333333333333

1322.0

Domain

RH1

Tgene

SPAG9

chr11:71193071

chr17:49048217

ENST00000357122

500_571

1219.3333333333333

1308.0

Domain

RH2

Tgene

SPAG9

chr11:71193071

chr17:49048217

ENST00000357122

7_95

1219.3333333333333

1308.0

Domain

RH1

Tgene

SPAG9

chr11:71193071

chr17:49048217

ENST00000505279

500_571

1223.3333333333333

1312.0

Domain

RH2

Tgene

SPAG9

chr11:71193071

chr17:49048217

ENST00000505279

7_95

1223.3333333333333

1312.0

Domain

RH1

Tgene

SPAG9

chr11:71193071

chr17:49048217

ENST00000510283

500_571

1089.3333333333333

1178.0

Domain

RH2

Tgene

SPAG9

chr11:71193071

chr17:49048217

ENST00000510283

7_95

1089.3333333333333

1178.0

Domain

RH1

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>990_NADSYN1_71193071_SPAG9_49048217_990_NADSYN1_71193071_SPAG9_49048217_ranked_0.pdb	NADSYN1	71193071	71193071	ENST00000357122	SPAG9	chr17	49048217	-	MGRKVTVATCALNQWALDFEGNLQRILKSIEIAKNRGARYRLGPELEICGYGCWDHYYESDTLLHSFQVLAALVESPVTQDIICDVGMPV MHRNVRYNCRVIFLNRKILLIRPKMALANEGNYRELRWFTPWSRSRHTEEYFLPRMIQDLTKQETVPFGDAVLVTWDTCIGSEICEELWT PHSPHIDMGLDGVEIITNASGSHQVLRKANTRVDLVTMVTSKNGGIYLLANQKGCDGDRLYYDGCAMIAMNGSVFAQGSQFSLDDVEVLT ATLDLEDVRSYRAEISSRNLAASRASPYPRVKVDFALSCHEDLLAPISEPIEWKYHSPEEEISLGPACWLWDFLRRSQQAGFLLPLSGGV DSAATACLIYSMCCQVCEAVRSGSQVISPQSSSSGTDLTGDKAGPSAQEPGSQTPLKSMLVISGGEGYIDFRMGDEGGESELLGEDLPLE	471

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

NADSYN1_pLDDT.png

SPAG9_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
NADSYN1
SPAG9

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to NADSYN1-SPAG9

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to NADSYN1-SPAG9

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source