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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:OSCP1-NF1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: OSCP1-NF1
FusionPDB ID: 61888
FusionGDB2.0 ID: 61888
HgeneTgene
Gene symbol

OSCP1

NF1

Gene ID

127700

4763

Gene nameorganic solute carrier partner 1neurofibromin 1
SynonymsC1orf102|NOR1NFNS|VRNF|WSS
Cytomap

1p34.3

17q11.2

Type of geneprotein-codingprotein-coding
Descriptionprotein OSCP1organic solute carrier protein 1organic solute transport protein 1oxidored nitro domain containing proteinoxidored-nitro domain-containing protein 1neurofibrominneurofibromatosis 1neurofibromatosis-related protein NF-1truncated neurofibromin 1
Modification date2020031320200322
UniProtAcc.

P21359

Ensembl transtripts involved in fusion geneENST idsENST00000235532, ENST00000315643, 
ENST00000354267, ENST00000356637, 
ENST00000433045, ENST00000495222, 
ENST00000417592, ENST00000431387, 
ENST00000444181, ENST00000581113, 
ENST00000356175, ENST00000358273, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 6 X 3=9028 X 30 X 15=12600
# samples 633
** MAII scorelog2(6/90*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(33/12600*10)=-5.25481389902883
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: OSCP1 [Title/Abstract] AND NF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)OSCP1(36915859)-NF1(29701031), # samples:3
Anticipated loss of major functional domain due to fusion event.OSCP1-NF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
OSCP1-NF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
OSCP1-NF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
OSCP1-NF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNF1

GO:0043547

positive regulation of GTPase activity

2121371


check buttonFusion gene breakpoints across OSCP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4MESOTCGA-UD-AAC4-01AOSCP1chr1

36915859

-NF1chr17

29701031

+
ChimerDB4MESOTCGA-UD-AAC4OSCP1chr1

36915858

-NF1chr17

29701030

+
ChimerDB4MESOTCGA-UD-AAC4OSCP1chr1

36915859

-NF1chr17

29701031

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000235532OSCP1chr136915859-ENST00000356175NF1chr1729701031+38591941336111
ENST00000235532OSCP1chr136915859-ENST00000358273NF1chr1729701031+38591941336111
ENST00000356637OSCP1chr136915859-ENST00000356175NF1chr1729701031+384117613318101
ENST00000356637OSCP1chr136915859-ENST00000358273NF1chr1729701031+384117613318101
ENST00000315643OSCP1chr136915859-ENST00000356175NF1chr1729701031+389322835370111
ENST00000315643OSCP1chr136915859-ENST00000358273NF1chr1729701031+389322835370111
ENST00000354267OSCP1chr136915859-ENST00000356175NF1chr1729701031+38511868328106
ENST00000354267OSCP1chr136915859-ENST00000358273NF1chr1729701031+38511868328106
ENST00000235532OSCP1chr136915858-ENST00000356175NF1chr1729701030+38591941336111
ENST00000235532OSCP1chr136915858-ENST00000358273NF1chr1729701030+38591941336111
ENST00000356637OSCP1chr136915858-ENST00000356175NF1chr1729701030+384117613318101
ENST00000356637OSCP1chr136915858-ENST00000358273NF1chr1729701030+384117613318101
ENST00000315643OSCP1chr136915858-ENST00000356175NF1chr1729701030+389322835370111
ENST00000315643OSCP1chr136915858-ENST00000358273NF1chr1729701030+389322835370111
ENST00000354267OSCP1chr136915858-ENST00000356175NF1chr1729701030+38511868328106
ENST00000354267OSCP1chr136915858-ENST00000358273NF1chr1729701030+38511868328106

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000235532ENST00000356175OSCP1chr136915859-NF1chr1729701031+0.280653330.7193467
ENST00000235532ENST00000358273OSCP1chr136915859-NF1chr1729701031+0.280653330.7193467
ENST00000356637ENST00000356175OSCP1chr136915859-NF1chr1729701031+0.275531650.72446835
ENST00000356637ENST00000358273OSCP1chr136915859-NF1chr1729701031+0.275531650.72446835
ENST00000315643ENST00000356175OSCP1chr136915859-NF1chr1729701031+0.27429370.72570634
ENST00000315643ENST00000358273OSCP1chr136915859-NF1chr1729701031+0.27429370.72570634
ENST00000354267ENST00000356175OSCP1chr136915859-NF1chr1729701031+0.276462550.72353745
ENST00000354267ENST00000358273OSCP1chr136915859-NF1chr1729701031+0.276462550.72353745
ENST00000235532ENST00000356175OSCP1chr136915858-NF1chr1729701030+0.280653330.7193467
ENST00000235532ENST00000358273OSCP1chr136915858-NF1chr1729701030+0.280653330.7193467
ENST00000356637ENST00000356175OSCP1chr136915858-NF1chr1729701030+0.275531650.72446835
ENST00000356637ENST00000358273OSCP1chr136915858-NF1chr1729701030+0.275531650.72446835
ENST00000315643ENST00000356175OSCP1chr136915858-NF1chr1729701030+0.27429370.72570634
ENST00000315643ENST00000358273OSCP1chr136915858-NF1chr1729701030+0.27429370.72570634
ENST00000354267ENST00000356175OSCP1chr136915858-NF1chr1729701030+0.276462550.72353745
ENST00000354267ENST00000358273OSCP1chr136915858-NF1chr1729701030+0.276462550.72353745

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>61888_61888_1_OSCP1-NF1_OSCP1_chr1_36915858_ENST00000235532_NF1_chr17_29701030_ENST00000356175_length(amino acids)=111AA_BP=64
LGRCGLAFRPLATEPRGSSPVQLVSSTMSVRTLPLLFLNLGGEMLYILDQRLRAQNIPGDKARKGIDKENVELSPTTGHCNSGRTRHGSA

--------------------------------------------------------------

>61888_61888_2_OSCP1-NF1_OSCP1_chr1_36915858_ENST00000235532_NF1_chr17_29701030_ENST00000358273_length(amino acids)=111AA_BP=64
LGRCGLAFRPLATEPRGSSPVQLVSSTMSVRTLPLLFLNLGGEMLYILDQRLRAQNIPGDKARKGIDKENVELSPTTGHCNSGRTRHGSA

--------------------------------------------------------------

>61888_61888_3_OSCP1-NF1_OSCP1_chr1_36915858_ENST00000315643_NF1_chr17_29701030_ENST00000356175_length(amino acids)=111AA_BP=64
MGRCGLAFRPLATEPRGSSPVQLVSSTMSVRTLPLLFLNLGGEMLYILDQRLRAQNIPGDKARKGIDKENVELSPTTGHCNSGRTRHGSA

--------------------------------------------------------------

>61888_61888_4_OSCP1-NF1_OSCP1_chr1_36915858_ENST00000315643_NF1_chr17_29701030_ENST00000358273_length(amino acids)=111AA_BP=64
MGRCGLAFRPLATEPRGSSPVQLVSSTMSVRTLPLLFLNLGGEMLYILDQRLRAQNIPGDKARKGIDKENVELSPTTGHCNSGRTRHGSA

--------------------------------------------------------------

>61888_61888_5_OSCP1-NF1_OSCP1_chr1_36915858_ENST00000354267_NF1_chr17_29701030_ENST00000356175_length(amino acids)=106AA_BP=59
MAFRPLATEPRGSSPVQLVSSTMSVRTLPLLFLNLGGEMLYILDQRLRAQNIPGDKARKGIDKENVELSPTTGHCNSGRTRHGSASQVQK

--------------------------------------------------------------

>61888_61888_6_OSCP1-NF1_OSCP1_chr1_36915858_ENST00000354267_NF1_chr17_29701030_ENST00000358273_length(amino acids)=106AA_BP=59
MAFRPLATEPRGSSPVQLVSSTMSVRTLPLLFLNLGGEMLYILDQRLRAQNIPGDKARKGIDKENVELSPTTGHCNSGRTRHGSASQVQK

--------------------------------------------------------------

>61888_61888_7_OSCP1-NF1_OSCP1_chr1_36915858_ENST00000356637_NF1_chr17_29701030_ENST00000356175_length(amino acids)=101AA_BP=54
MATEPRGSSPVQLVSSTMSVRTLPLLFLNLGGEMLYILDQRLRAQNIPGDKARKGIDKENVELSPTTGHCNSGRTRHGSASQVQKQRSAG

--------------------------------------------------------------

>61888_61888_8_OSCP1-NF1_OSCP1_chr1_36915858_ENST00000356637_NF1_chr17_29701030_ENST00000358273_length(amino acids)=101AA_BP=54
MATEPRGSSPVQLVSSTMSVRTLPLLFLNLGGEMLYILDQRLRAQNIPGDKARKGIDKENVELSPTTGHCNSGRTRHGSASQVQKQRSAG

--------------------------------------------------------------

>61888_61888_9_OSCP1-NF1_OSCP1_chr1_36915859_ENST00000235532_NF1_chr17_29701031_ENST00000356175_length(amino acids)=111AA_BP=64
LGRCGLAFRPLATEPRGSSPVQLVSSTMSVRTLPLLFLNLGGEMLYILDQRLRAQNIPGDKARKGIDKENVELSPTTGHCNSGRTRHGSA

--------------------------------------------------------------

>61888_61888_10_OSCP1-NF1_OSCP1_chr1_36915859_ENST00000235532_NF1_chr17_29701031_ENST00000358273_length(amino acids)=111AA_BP=64
LGRCGLAFRPLATEPRGSSPVQLVSSTMSVRTLPLLFLNLGGEMLYILDQRLRAQNIPGDKARKGIDKENVELSPTTGHCNSGRTRHGSA

--------------------------------------------------------------

>61888_61888_11_OSCP1-NF1_OSCP1_chr1_36915859_ENST00000315643_NF1_chr17_29701031_ENST00000356175_length(amino acids)=111AA_BP=64
MGRCGLAFRPLATEPRGSSPVQLVSSTMSVRTLPLLFLNLGGEMLYILDQRLRAQNIPGDKARKGIDKENVELSPTTGHCNSGRTRHGSA

--------------------------------------------------------------

>61888_61888_12_OSCP1-NF1_OSCP1_chr1_36915859_ENST00000315643_NF1_chr17_29701031_ENST00000358273_length(amino acids)=111AA_BP=64
MGRCGLAFRPLATEPRGSSPVQLVSSTMSVRTLPLLFLNLGGEMLYILDQRLRAQNIPGDKARKGIDKENVELSPTTGHCNSGRTRHGSA

--------------------------------------------------------------

>61888_61888_13_OSCP1-NF1_OSCP1_chr1_36915859_ENST00000354267_NF1_chr17_29701031_ENST00000356175_length(amino acids)=106AA_BP=59
MAFRPLATEPRGSSPVQLVSSTMSVRTLPLLFLNLGGEMLYILDQRLRAQNIPGDKARKGIDKENVELSPTTGHCNSGRTRHGSASQVQK

--------------------------------------------------------------

>61888_61888_14_OSCP1-NF1_OSCP1_chr1_36915859_ENST00000354267_NF1_chr17_29701031_ENST00000358273_length(amino acids)=106AA_BP=59
MAFRPLATEPRGSSPVQLVSSTMSVRTLPLLFLNLGGEMLYILDQRLRAQNIPGDKARKGIDKENVELSPTTGHCNSGRTRHGSASQVQK

--------------------------------------------------------------

>61888_61888_15_OSCP1-NF1_OSCP1_chr1_36915859_ENST00000356637_NF1_chr17_29701031_ENST00000356175_length(amino acids)=101AA_BP=54
MATEPRGSSPVQLVSSTMSVRTLPLLFLNLGGEMLYILDQRLRAQNIPGDKARKGIDKENVELSPTTGHCNSGRTRHGSASQVQKQRSAG

--------------------------------------------------------------

>61888_61888_16_OSCP1-NF1_OSCP1_chr1_36915859_ENST00000356637_NF1_chr17_29701031_ENST00000358273_length(amino acids)=101AA_BP=54
MATEPRGSSPVQLVSSTMSVRTLPLLFLNLGGEMLYILDQRLRAQNIPGDKARKGIDKENVELSPTTGHCNSGRTRHGSASQVQKQRSAG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:36915859/chr17:29701031)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.NF1

P21359

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Stimulates the GTPase activity of Ras. NF1 shows greater affinity for Ras GAP, but lower specific activity. May be a regulator of Ras activity. {ECO:0000269|PubMed:2121371, ECO:0000269|PubMed:8417346}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNF1chr1:36915858chr17:29701030ENST000004313870151352_13550594.0Compositional biasNote=Poly-Ser
TgeneNF1chr1:36915859chr17:29701031ENST000004313870151352_13550594.0Compositional biasNote=Poly-Ser
TgeneNF1chr1:36915858chr17:29701030ENST000004313870151235_14510594.0DomainRas-GAP
TgeneNF1chr1:36915858chr17:29701030ENST000004313870151580_17380594.0DomainCRAL-TRIO
TgeneNF1chr1:36915859chr17:29701031ENST000004313870151235_14510594.0DomainRas-GAP
TgeneNF1chr1:36915859chr17:29701031ENST000004313870151580_17380594.0DomainCRAL-TRIO
TgeneNF1chr1:36915858chr17:29701030ENST000004313870152555_25710594.0MotifNote=Bipartite nuclear localization signal
TgeneNF1chr1:36915859chr17:29701031ENST000004313870152555_25710594.0MotifNote=Bipartite nuclear localization signal
TgeneNF1chr1:36915858chr17:29701030ENST000004313870151580_18370594.0RegionNote=Lipid binding
TgeneNF1chr1:36915859chr17:29701031ENST000004313870151580_18370594.0RegionNote=Lipid binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNF1chr1:36915858chr17:29701030ENST0000035617555571352_13552771.33333333333352819.0Compositional biasNote=Poly-Ser
TgeneNF1chr1:36915858chr17:29701030ENST0000035827356581352_13552792.33333333333352840.0Compositional biasNote=Poly-Ser
TgeneNF1chr1:36915859chr17:29701031ENST0000035617555571352_13552771.33333333333352819.0Compositional biasNote=Poly-Ser
TgeneNF1chr1:36915859chr17:29701031ENST0000035827356581352_13552792.33333333333352840.0Compositional biasNote=Poly-Ser
TgeneNF1chr1:36915858chr17:29701030ENST0000035617555571235_14512771.33333333333352819.0DomainRas-GAP
TgeneNF1chr1:36915858chr17:29701030ENST0000035617555571580_17382771.33333333333352819.0DomainCRAL-TRIO
TgeneNF1chr1:36915858chr17:29701030ENST0000035827356581235_14512792.33333333333352840.0DomainRas-GAP
TgeneNF1chr1:36915858chr17:29701030ENST0000035827356581580_17382792.33333333333352840.0DomainCRAL-TRIO
TgeneNF1chr1:36915859chr17:29701031ENST0000035617555571235_14512771.33333333333352819.0DomainRas-GAP
TgeneNF1chr1:36915859chr17:29701031ENST0000035617555571580_17382771.33333333333352819.0DomainCRAL-TRIO
TgeneNF1chr1:36915859chr17:29701031ENST0000035827356581235_14512792.33333333333352840.0DomainRas-GAP
TgeneNF1chr1:36915859chr17:29701031ENST0000035827356581580_17382792.33333333333352840.0DomainCRAL-TRIO
TgeneNF1chr1:36915858chr17:29701030ENST0000035617555572555_25712771.33333333333352819.0MotifNote=Bipartite nuclear localization signal
TgeneNF1chr1:36915858chr17:29701030ENST0000035827356582555_25712792.33333333333352840.0MotifNote=Bipartite nuclear localization signal
TgeneNF1chr1:36915859chr17:29701031ENST0000035617555572555_25712771.33333333333352819.0MotifNote=Bipartite nuclear localization signal
TgeneNF1chr1:36915859chr17:29701031ENST0000035827356582555_25712792.33333333333352840.0MotifNote=Bipartite nuclear localization signal
TgeneNF1chr1:36915858chr17:29701030ENST0000035617555571580_18372771.33333333333352819.0RegionNote=Lipid binding
TgeneNF1chr1:36915858chr17:29701030ENST0000035827356581580_18372792.33333333333352840.0RegionNote=Lipid binding
TgeneNF1chr1:36915859chr17:29701031ENST0000035617555571580_18372771.33333333333352819.0RegionNote=Lipid binding
TgeneNF1chr1:36915859chr17:29701031ENST0000035827356581580_18372792.33333333333352840.0RegionNote=Lipid binding


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>37_OSCP1_36915859_NF1_29701031_ranked_0.pdbOSCP13691585836915859ENST00000358273NF1chr1729701031+
LGRCGLAFRPLATEPRGSSPVQLVSSTMSVRTLPLLFLNLGGEMLYILDQRLRAQNIPGDKARKGIDKENVELSPTTGHCNSGRTRHGSA
111


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
OSCP1_pLDDT.png
all structure
all structure
NF1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
NF1HRAS, SMARCA4, POLR2A, TIRAP, SIRT7, VCP, NSFL1C, CAV1, YWHAB, FAF2, NXF1, CCDC8, HLA-DPA1, EFNB2, CD274, TNFSF13B, CA14, SLAMF1, VSIG4, TGOLN2, HTR6, NOSIP, KRAS, CLK1, CDC5L, APP, YWHAH, PML, TRAF6, PTEN, SDC2, EGFR, CD79B, P4HA3, SCN3B, VSIG1, SIGLECL1, EPHA1, FAM174A, KCTD3, KIF13B, ZBTB21, KSR1, CGN, GIGYF1, LRFN1, RTKN, MAST3, DENND1A, SH3PXD2A, SRGAP2, DENND4C, PPM1H, EIF4E2, SIPA1L1, LIMA1, RALGPS2, MAGI1, CBY1, TESK2, CDC25C, DCLK1, GIGYF2, HDAC4, LPIN3, ZNF638, CAMSAP2, NADK, MAPKAP1, SRSF12, RASAL2, SYDE1, KIAA1804, TIAM1, AGAP1, CDC25B, CDK16, SH3RF3, PHLDB2, PLEKHA7, KIF1C, OSBPL6, FAM110B, USP21, NAV1, TANC2, PTPN13, FAM53C, ANKRD34A, STARD13, PTPN14, GAB2, DENND4A, INPP5E, TOP1, TOP2A, TOP3A, NRAS, ZUFSP, ESR2, LZTR1, SPRED1, MYC, LIMK2, KIAA1429, CTDP1, DYRK1A, F12, AKT1, EPHA2, MAP2K3, RAF1, SOX4, BIRC3, ORF7a, LCK, NOLC1, N, nsp7, KIF14, PRC1, MKI67, FASN, NR3C1, DDRGK1, FLOT1, LYN, PFN1, RHOB, ATG7, EFS, C19orf38, CDHR2, ITFG3, CD80, SEMA4C, DGCR2, EFNA4, PTGES2, LRRC25, EVI2A, EFNB1, TPST2, C3orf18, GYPA, HCST, TACSTD2, OPALIN, IL2RA, CD226, SIRT6,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
OSCP1
NF1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to OSCP1-NF1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to OSCP1-NF1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNF1C0027831Neurofibromatosis 144CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneNF1C1708353Hereditary Paraganglioma-Pheochromocytoma Syndrome10CLINGEN
TgeneNF1C0349639Juvenile Myelomonocytic Leukemia7CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneNF1C2931482Neurofibromatosis-Noonan syndrome6CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneNF1C0553586Cafe-au-lait macules with pulmonary stenosis5CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneNF1C0162678Neurofibromatoses3CGI;CTD_human;GENOMICS_ENGLAND
TgeneNF1C0004114Astrocytoma2CTD_human
TgeneNF1C0023467Leukemia, Myelocytic, Acute2CTD_human
TgeneNF1C0025202melanoma2CGI;CTD_human
TgeneNF1C0026998Acute Myeloid Leukemia, M12CTD_human
TgeneNF1C0205768Subependymal Giant Cell Astrocytoma2CTD_human
TgeneNF1C0206727Nerve Sheath Tumors2CTD_human
TgeneNF1C0280783Juvenile Pilocytic Astrocytoma2CTD_human
TgeneNF1C0280785Diffuse Astrocytoma2CTD_human
TgeneNF1C0334579Anaplastic astrocytoma2CTD_human
TgeneNF1C0334580Protoplasmic astrocytoma2CTD_human
TgeneNF1C0334581Gemistocytic astrocytoma2CTD_human
TgeneNF1C0334582Fibrillary Astrocytoma2CTD_human
TgeneNF1C0334583Pilocytic Astrocytoma2CTD_human
TgeneNF1C0338070Childhood Cerebral Astrocytoma2CTD_human
TgeneNF1C0547065Mixed oligoastrocytoma2CTD_human
TgeneNF1C0750935Cerebral Astrocytoma2CTD_human
TgeneNF1C0750936Intracranial Astrocytoma2CTD_human
TgeneNF1C0751689Peripheral Nerve Sheath Neoplasm2CTD_human
TgeneNF1C0751691Perineurioma2CTD_human
TgeneNF1C1704230Grade I Astrocytoma2CTD_human
TgeneNF1C1834235NEUROFIBROMATOSIS, FAMILIAL SPINAL2CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneNF1C1879321Acute Myeloid Leukemia (AML-M2)2CTD_human
TgeneNF1C0001430Adenoma1CTD_human
TgeneNF1C0004352Autistic Disorder1CTD_human
TgeneNF1C0016057Fibrosarcoma1CTD_human
TgeneNF1C0017636Glioblastoma1CTD_human
TgeneNF1C0017638Glioma1CGI;CTD_human
TgeneNF1C0020796Profound Mental Retardation1CTD_human
TgeneNF1C0023186Learning Disorders1CTD_human
TgeneNF1C0023827liposarcoma1CTD_human
TgeneNF1C0025363Mental Retardation, Psychosocial1CTD_human
TgeneNF1C0026654Moyamoya Disease1GENOMICS_ENGLAND
TgeneNF1C0027809Neurilemmoma1CTD_human
TgeneNF1C0027830neurofibroma1CTD_human
TgeneNF1C0027962Melanocytic nevus1CTD_human
TgeneNF1C0028326Noonan Syndrome1GENOMICS_ENGLAND
TgeneNF1C0031511Pheochromocytoma1CTD_human
TgeneNF1C0035320Retinal Neovascularization1CTD_human
TgeneNF1C0205646Adenoma, Basal Cell1CTD_human
TgeneNF1C0205647Follicular adenoma1CTD_human
TgeneNF1C0205648Adenoma, Microcystic1CTD_human
TgeneNF1C0205649Adenoma, Monomorphic1CTD_human
TgeneNF1C0205650Papillary adenoma1CTD_human
TgeneNF1C0205651Adenoma, Trabecular1CTD_human
TgeneNF1C0205824Liposarcoma, Dedifferentiated1CTD_human
TgeneNF1C0205825Liposarcoma, Pleomorphic1CTD_human
TgeneNF1C0205944Sarcoma, Epithelioid1CTD_human
TgeneNF1C0205945Sarcoma, Spindle Cell1CTD_human
TgeneNF1C0259783mixed gliomas1CTD_human
TgeneNF1C0334588Giant Cell Glioblastoma1CTD_human
TgeneNF1C0555198Malignant Glioma1CTD_human
TgeneNF1C0751262Adult Learning Disorders1CTD_human
TgeneNF1C0751263Learning Disturbance1CTD_human
TgeneNF1C0751265Learning Disabilities1CTD_human
TgeneNF1C0751374Schwannomatosis, Plexiform1CTD_human
TgeneNF1C0917816Mental deficiency1CTD_human
TgeneNF1C0917817Neurofibromatosis 31CTD_human
TgeneNF1C1257877Pheochromocytoma, Extra-Adrenal1CTD_human
TgeneNF1C1261473Sarcoma1CTD_human
TgeneNF1C1330966Developmental Academic Disorder1CTD_human
TgeneNF1C1370889Liposarcoma, well differentiated1CTD_human
TgeneNF1C1621958Glioblastoma Multiforme1CTD_human
TgeneNF1C3150928NF1 Microdeletion Syndrome1ORPHANET
TgeneNF1C3714756Intellectual Disability1CTD_human