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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:OSGIN2-RIPK2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: OSGIN2-RIPK2
	FusionPDB ID: 61903
	FusionGDB2.0 ID: 61903
		Hgene	Tgene
	Gene symbol	OSGIN2	RIPK2
	Gene ID	734	8767
	Gene name	oxidative stress induced growth inhibitor family member 2	receptor interacting serine/threonine kinase 2
	Synonyms	C8orf1\|hT41	CARD3\|CARDIAK\|CCK\|GIG30\|RICK\|RIP2
	Cytomap	8q21.3	8q21.3
	Type of gene	protein-coding	protein-coding
	Description	oxidative stress-induced growth inhibitor 2	receptor-interacting serine/threonine-protein kinase 2CARD-carrying kinaseCARD-containing IL-1 beta ICE-kinaseCARD-containing interleukin-1 beta-converting enzyme (ICE)-associated kinaseRIP-2growth-inhibiting gene 30receptor-interacting protein (RIP
	Modification date	20200313	20200313
	UniProtAcc	.	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000297438, ENST00000451899, ENST00000520659,	ENST00000540020, ENST00000220751,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	2 X 3 X 5=30	4 X 6 X 5=120
	# samples	6	6
	** MAII score	log2(6/30*10)=1 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0	log2(6/120*10)=-1 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: OSGIN2 [Title/Abstract] AND RIPK2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	OSGIN2(90926974)-RIPK2(90775057), # samples:3 OSGIN2(90926974)-RIPK2(90798821), # samples:3
Anticipated loss of major functional domain due to fusion event.	OSGIN2-RIPK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. OSGIN2-RIPK2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. OSGIN2-RIPK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. OSGIN2-RIPK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. OSGIN2-RIPK2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. OSGIN2-RIPK2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. OSGIN2-RIPK2 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	RIPK2	GO:0010800	positive regulation of peptidyl-threonine phosphorylation	21887730
Tgene	RIPK2	GO:0010942	positive regulation of cell death	16920334
Tgene	RIPK2	GO:0033138	positive regulation of peptidyl-serine phosphorylation	21887730
Tgene	RIPK2	GO:0034134	toll-like receptor 2 signaling pathway	11894098
Tgene	RIPK2	GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB signaling	10329646
Tgene	RIPK2	GO:0045087	innate immune response	23806334
Tgene	RIPK2	GO:0050718	positive regulation of interleukin-1 beta secretion	11432859
Tgene	RIPK2	GO:0050731	positive regulation of peptidyl-tyrosine phosphorylation	21887730
Tgene	RIPK2	GO:0051092	positive regulation of NF-kappaB transcription factor activity	11821383
Tgene	RIPK2	GO:0070431	nucleotide-binding oligomerization domain containing 2 signaling pathway	23806334
Tgene	RIPK2	GO:0071225	cellular response to muramyl dipeptide	21887730
Tgene	RIPK2	GO:0097202	activation of cysteine-type endopeptidase activity	11821383

Fusion gene breakpoints across OSGIN2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RIPK2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-OL-A6VO-01A	OSGIN2	chr8	90926974	-	RIPK2	chr8	90775057	+
ChimerDB4	BRCA	TCGA-OL-A6VO-01A	OSGIN2	chr8	90926974	+	RIPK2	chr8	90775057	+
ChimerDB4	HNSC	TCGA-CV-5430-01A	OSGIN2	chr8	90926974	-	RIPK2	chr8	90798821	+
ChimerDB4	HNSC	TCGA-CV-5430-01A	OSGIN2	chr8	90926974	+	RIPK2	chr8	90798821	+
ChimerDB4	HNSC	TCGA-CV-5430	OSGIN2	chr8	90926974	+	RIPK2	chr8	90798821	+
ChimerDB4	LUAD	TCGA-86-7711-01A	OSGIN2	chr8	90921949	+	RIPK2	chr8	90801549	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000297438	OSGIN2	chr8	90926974	+	ENST00000220751	RIPK2	chr8	90798821	+	1992	751	334	1344	336
ENST00000297438	OSGIN2	chr8	90926974	+	ENST00000540020	RIPK2	chr8	90798821	+	1389	751	334	1344	336
ENST00000451899	OSGIN2	chr8	90926974	+	ENST00000220751	RIPK2	chr8	90798821	+	2029	788	53	1381	442
ENST00000451899	OSGIN2	chr8	90926974	+	ENST00000540020	RIPK2	chr8	90798821	+	1426	788	53	1381	442
ENST00000520659	OSGIN2	chr8	90926974	+	ENST00000220751	RIPK2	chr8	90798821	+	1802	561	33	1154	373
ENST00000520659	OSGIN2	chr8	90926974	+	ENST00000540020	RIPK2	chr8	90798821	+	1199	561	33	1154	373
ENST00000297438	OSGIN2	chr8	90921949	+	ENST00000220751	RIPK2	chr8	90801549	+	1569	422	334	921	195
ENST00000297438	OSGIN2	chr8	90921949	+	ENST00000540020	RIPK2	chr8	90801549	+	966	422	334	921	195
ENST00000451899	OSGIN2	chr8	90921949	+	ENST00000220751	RIPK2	chr8	90801549	+	1606	459	53	958	301
ENST00000451899	OSGIN2	chr8	90921949	+	ENST00000540020	RIPK2	chr8	90801549	+	1003	459	53	958	301
ENST00000520659	OSGIN2	chr8	90921949	+	ENST00000220751	RIPK2	chr8	90801549	+	1379	232	33	731	232
ENST00000520659	OSGIN2	chr8	90921949	+	ENST00000540020	RIPK2	chr8	90801549	+	776	232	33	731	232

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000297438	ENST00000220751	OSGIN2	chr8	90926974	+	RIPK2	chr8	90798821	+	0.000351674	0.99964833
ENST00000297438	ENST00000540020	OSGIN2	chr8	90926974	+	RIPK2	chr8	90798821	+	0.000848673	0.99915135
ENST00000451899	ENST00000220751	OSGIN2	chr8	90926974	+	RIPK2	chr8	90798821	+	0.000755716	0.99924433
ENST00000451899	ENST00000540020	OSGIN2	chr8	90926974	+	RIPK2	chr8	90798821	+	0.00237943	0.9976205
ENST00000520659	ENST00000220751	OSGIN2	chr8	90926974	+	RIPK2	chr8	90798821	+	0.000458658	0.9995414
ENST00000520659	ENST00000540020	OSGIN2	chr8	90926974	+	RIPK2	chr8	90798821	+	0.001251584	0.9987484
ENST00000297438	ENST00000220751	OSGIN2	chr8	90921949	+	RIPK2	chr8	90801549	+	0.002057233	0.99794275
ENST00000297438	ENST00000540020	OSGIN2	chr8	90921949	+	RIPK2	chr8	90801549	+	0.00415263	0.9958474
ENST00000451899	ENST00000220751	OSGIN2	chr8	90921949	+	RIPK2	chr8	90801549	+	0.000738384	0.99926156
ENST00000451899	ENST00000540020	OSGIN2	chr8	90921949	+	RIPK2	chr8	90801549	+	0.003760727	0.9962393
ENST00000520659	ENST00000220751	OSGIN2	chr8	90921949	+	RIPK2	chr8	90801549	+	0.000428634	0.9995714
ENST00000520659	ENST00000540020	OSGIN2	chr8	90921949	+	RIPK2	chr8	90801549	+	0.00164442	0.99835557

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>61903_61903_1_OSGIN2-RIPK2_OSGIN2_chr8_90921949_ENST00000297438_RIPK2_chr8_90801549_ENST00000220751_length(amino acids)=195AA_BP=29
MGRKVKAMPLVEETSLLEDSSVTFPVVIIGKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGI
AQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILV

--------------------------------------------------------------

>61903_61903_2_OSGIN2-RIPK2_OSGIN2_chr8_90921949_ENST00000297438_RIPK2_chr8_90801549_ENST00000540020_length(amino acids)=195AA_BP=29
MGRKVKAMPLVEETSLLEDSSVTFPVVIIGKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGI
AQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILV

--------------------------------------------------------------

>61903_61903_3_OSGIN2-RIPK2_OSGIN2_chr8_90921949_ENST00000451899_RIPK2_chr8_90801549_ENST00000220751_length(amino acids)=301AA_BP=135
MQARSGSRYLEADSGATEPGQPRQRRGARQGRPADPATPSQRAPRAGSLAGGGGGGHGGRARAPLAQRSMPVWCCRCSLAGHFRNYSDTE
TEGEIFNSLVQYFGDNLGRKVKAMPLVEETSLLEDSSVTFPVVIIGKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAII
NPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKL

--------------------------------------------------------------

>61903_61903_4_OSGIN2-RIPK2_OSGIN2_chr8_90921949_ENST00000451899_RIPK2_chr8_90801549_ENST00000540020_length(amino acids)=301AA_BP=135
MQARSGSRYLEADSGATEPGQPRQRRGARQGRPADPATPSQRAPRAGSLAGGGGGGHGGRARAPLAQRSMPVWCCRCSLAGHFRNYSDTE
TEGEIFNSLVQYFGDNLGRKVKAMPLVEETSLLEDSSVTFPVVIIGKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAII
NPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKL

--------------------------------------------------------------

>61903_61903_5_OSGIN2-RIPK2_OSGIN2_chr8_90921949_ENST00000520659_RIPK2_chr8_90801549_ENST00000220751_length(amino acids)=232AA_BP=66
MPVWCCRCSLAGHFRNYSDTETEGEIFNSLVQYFGDNLGRKVKAMPLVEETSLLEDSSVTFPVVIIGKAQDCYFMKLHHCPGNHSWDSTI
SGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVR

--------------------------------------------------------------

>61903_61903_6_OSGIN2-RIPK2_OSGIN2_chr8_90921949_ENST00000520659_RIPK2_chr8_90801549_ENST00000540020_length(amino acids)=232AA_BP=66
MPVWCCRCSLAGHFRNYSDTETEGEIFNSLVQYFGDNLGRKVKAMPLVEETSLLEDSSVTFPVVIIGKAQDCYFMKLHHCPGNHSWDSTI
SGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVR

--------------------------------------------------------------

>61903_61903_7_OSGIN2-RIPK2_OSGIN2_chr8_90926974_ENST00000297438_RIPK2_chr8_90798821_ENST00000220751_length(amino acids)=336AA_BP=139
MGRKVKAMPLVEETSLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPYLSSEAIHPNTILNSKLEEARHLSIVDQDLEYLSEGLEGRSSN
PVAVLFDTLLHPDADFGYDYPSVLHWKLEQHHYIPHVVLGKGPPGGAWHESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMK
LHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDY

--------------------------------------------------------------

>61903_61903_8_OSGIN2-RIPK2_OSGIN2_chr8_90926974_ENST00000297438_RIPK2_chr8_90798821_ENST00000540020_length(amino acids)=336AA_BP=139
MGRKVKAMPLVEETSLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPYLSSEAIHPNTILNSKLEEARHLSIVDQDLEYLSEGLEGRSSN
PVAVLFDTLLHPDADFGYDYPSVLHWKLEQHHYIPHVVLGKGPPGGAWHESCGSSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMK
LHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDY

--------------------------------------------------------------

>61903_61903_9_OSGIN2-RIPK2_OSGIN2_chr8_90926974_ENST00000451899_RIPK2_chr8_90798821_ENST00000220751_length(amino acids)=442AA_BP=245
MQARSGSRYLEADSGATEPGQPRQRRGARQGRPADPATPSQRAPRAGSLAGGGGGGHGGRARAPLAQRSMPVWCCRCSLAGHFRNYSDTE
TEGEIFNSLVQYFGDNLGRKVKAMPLVEETSLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPYLSSEAIHPNTILNSKLEEARHLSIVD
QDLEYLSEGLEGRSSNPVAVLFDTLLHPDADFGYDYPSVLHWKLEQHHYIPHVVLGKGPPGGAWHESCGSSQLHENSGSPETSRSLPAPQ
DNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQ

--------------------------------------------------------------

>61903_61903_10_OSGIN2-RIPK2_OSGIN2_chr8_90926974_ENST00000451899_RIPK2_chr8_90798821_ENST00000540020_length(amino acids)=442AA_BP=245
MQARSGSRYLEADSGATEPGQPRQRRGARQGRPADPATPSQRAPRAGSLAGGGGGGHGGRARAPLAQRSMPVWCCRCSLAGHFRNYSDTE
TEGEIFNSLVQYFGDNLGRKVKAMPLVEETSLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPYLSSEAIHPNTILNSKLEEARHLSIVD
QDLEYLSEGLEGRSSNPVAVLFDTLLHPDADFGYDYPSVLHWKLEQHHYIPHVVLGKGPPGGAWHESCGSSQLHENSGSPETSRSLPAPQ
DNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQ

--------------------------------------------------------------

>61903_61903_11_OSGIN2-RIPK2_OSGIN2_chr8_90926974_ENST00000520659_RIPK2_chr8_90798821_ENST00000220751_length(amino acids)=373AA_BP=176
MPVWCCRCSLAGHFRNYSDTETEGEIFNSLVQYFGDNLGRKVKAMPLVEETSLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPYLSSEA
IHPNTILNSKLEEARHLSIVDQDLEYLSEGLEGRSSNPVAVLFDTLLHPDADFGYDYPSVLHWKLEQHHYIPHVVLGKGPPGGAWHESCG
SSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQ
QWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVS

--------------------------------------------------------------

>61903_61903_12_OSGIN2-RIPK2_OSGIN2_chr8_90926974_ENST00000520659_RIPK2_chr8_90798821_ENST00000540020_length(amino acids)=373AA_BP=176
MPVWCCRCSLAGHFRNYSDTETEGEIFNSLVQYFGDNLGRKVKAMPLVEETSLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPYLSSEA
IHPNTILNSKLEEARHLSIVDQDLEYLSEGLEGRSSNPVAVLFDTLLHPDADFGYDYPSVLHWKLEQHHYIPHVVLGKGPPGGAWHESCG
SSQLHENSGSPETSRSLPAPQDNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQ
QWIQSKREDIVNQMTEACLNQSLDALLSRDLIMKEDYELVSTKPTRTSKVRQLLDTTDIQGEEFAKVIVQKLKDNKQMGLQPYPEILVVS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:90926974/chr8:90775057)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	.
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RIPK2

chr8:90921949

chr8:90801549

ENST00000220751

432_524

374.3333333333333

541.0

Domain

CARD

Tgene

RIPK2

chr8:90921949

chr8:90801549

ENST00000540020

432_524

237.33333333333334

404.0

Domain

CARD

Tgene

RIPK2

chr8:90926974

chr8:90798821

ENST00000220751

432_524

343.0

541.0

Domain

CARD

Tgene

RIPK2

chr8:90926974

chr8:90798821

ENST00000540020

432_524

206.0

404.0

Domain

CARD

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RIPK2

chr8:90921949

chr8:90801549

ENST00000220751

18_294

374.3333333333333

541.0

Domain

Protein kinase

Tgene

RIPK2

chr8:90921949

chr8:90801549

ENST00000540020

18_294

237.33333333333334

404.0

Domain

Protein kinase

Tgene

RIPK2

chr8:90926974

chr8:90798821

ENST00000220751

18_294

343.0

541.0

Domain

Protein kinase

Tgene

RIPK2

chr8:90926974

chr8:90798821

ENST00000540020

18_294

206.0

404.0

Domain

Protein kinase

Tgene

RIPK2

chr8:90921949

chr8:90801549

ENST00000220751

24_32

374.3333333333333

541.0

Nucleotide binding

ATP

Tgene

RIPK2

chr8:90921949

chr8:90801549

ENST00000540020

24_32

237.33333333333334

404.0

Nucleotide binding

ATP

Tgene

RIPK2

chr8:90926974

chr8:90798821

ENST00000220751

24_32

343.0

541.0

Nucleotide binding

ATP

Tgene

RIPK2

chr8:90926974

chr8:90798821

ENST00000540020

24_32

206.0

404.0

Nucleotide binding

ATP

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>927_OSGIN2_90926974_RIPK2_90798821_927_OSGIN2_90926974_RIPK2_90798821_ranked_0.pdb	OSGIN2	90921949	90926974	ENST00000540020	RIPK2	chr8	90798821	+	MQARSGSRYLEADSGATEPGQPRQRRGARQGRPADPATPSQRAPRAGSLAGGGGGGHGGRARAPLAQRSMPVWCCRCSLAGHFRNYSDTE TEGEIFNSLVQYFGDNLGRKVKAMPLVEETSLLEDSSVTFPVVIIGNGPSGICLSYMLSGYRPYLSSEAIHPNTILNSKLEEARHLSIVD QDLEYLSEGLEGRSSNPVAVLFDTLLHPDADFGYDYPSVLHWKLEQHHYIPHVVLGKGPPGGAWHESCGSSQLHENSGSPETSRSLPAPQ DNDFLSRKAQDCYFMKLHHCPGNHSWDSTISGSQRAAFCDHKTTPCSSAIINPLSTAGNSERLQPGIAQQWIQSKREDIVNQMTEACLNQ	442

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

OSGIN2_pLDDT.png

RIPK2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
OSGIN2
RIPK2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to OSGIN2-RIPK2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to OSGIN2-RIPK2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source