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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:PCM1-RET

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: PCM1-RET
FusionPDB ID: 63341
FusionGDB2.0 ID: 63341
HgeneTgene
Gene symbol

PCM1

RET

Gene ID

5108

5979

Gene namepericentriolar material 1ret proto-oncogene
SynonymsPTC4|RET/PCM-1CDHF12|CDHR16|HSCR1|MEN2A|MEN2B|MTC1|PTC|RET-ELE1
Cytomap

8p22

10q11.21

Type of geneprotein-codingprotein-coding
Descriptionpericentriolar material 1 proteinPCM-1hPCM-1pericentriolar material 1, PCM1proto-oncogene tyrosine-protein kinase receptor RetRET receptor tyrosine kinasecadherin family member 12cadherin-related family member 16proto-oncogene c-Retrearranged during transfectionret proto-oncogene (multiple endocrine neoplasia and medullary
Modification date2020032720200322
UniProtAcc

Q15154

RTL1

Ensembl transtripts involved in fusion geneENST idsENST00000325083, ENST00000327578, 
ENST00000519253, ENST00000524226, 
ENST00000518537, ENST00000518936, 
ENST00000340058, ENST00000355710, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 16 X 12=307232 X 31 X 11=10912
# samples 1648
** MAII scorelog2(16/3072*10)=-4.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(48/10912*10)=-4.50673733341565
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: PCM1 [Title/Abstract] AND RET [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)PCM1(17851129)-RET(43612030), # samples:2
Anticipated loss of major functional domain due to fusion event.PCM1-RET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PCM1-RET seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
PCM1-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PCM1-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
PCM1-RET seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
PCM1-RET seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
PCM1-RET seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
PCM1-RET seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
PCM1-RET seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneRET

GO:0030155

regulation of cell adhesion

21357690

TgeneRET

GO:0030335

positive regulation of cell migration

20702524

TgeneRET

GO:0033619

membrane protein proteolysis

21357690

TgeneRET

GO:0033630

positive regulation of cell adhesion mediated by integrin

20702524

TgeneRET

GO:0035860

glial cell-derived neurotrophic factor receptor signaling pathway

28953886

TgeneRET

GO:0043410

positive regulation of MAPK cascade

28846099


check buttonFusion gene breakpoints across PCM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across RET (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4adenocarcinomaAJ297349PCM1chr8

17851129

RETchr10

43612030
ChimerKB3..PCM1chr8

17851128

+RETchr10

43612031

+
ChimerKB3..PCM1chr8

17851129

+RETchr10

43612030

+
ChimerKB3..PCM1chr8

17867253

+RETchr10

43619118

+
ChiTaRS5.0N/AAJ297349PCM1chr8

17851129

+RETchr10

43612030

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000325083PCM1chr817851128+ENST00000355710RETchr1043612031+8557526643964742011
ENST00000325083PCM1chr817851128+ENST00000340058RETchr1043612031+7099526643963481969
ENST00000519253PCM1chr817851128+ENST00000355710RETchr1043612031+8345505425162622003
ENST00000519253PCM1chr817851128+ENST00000340058RETchr1043612031+6887505425161361961
ENST00000524226PCM1chr817851128+ENST00000355710RETchr1043612031+801547245959321957
ENST00000524226PCM1chr817851128+ENST00000340058RETchr1043612031+655747245958061915
ENST00000327578PCM1chr817851128+ENST00000355710RETchr1043612031+43371046232254743
ENST00000327578PCM1chr817851128+ENST00000340058RETchr1043612031+28791046232128701
ENST00000325083PCM1chr817851129+ENST00000355710RETchr1043612030+8557526643964742011
ENST00000325083PCM1chr817851129+ENST00000340058RETchr1043612030+7099526643963481969
ENST00000519253PCM1chr817851129+ENST00000355710RETchr1043612030+8345505425162622003
ENST00000519253PCM1chr817851129+ENST00000340058RETchr1043612030+6887505425161361961
ENST00000524226PCM1chr817851129+ENST00000355710RETchr1043612030+801547245959321957
ENST00000524226PCM1chr817851129+ENST00000340058RETchr1043612030+655747245958061915
ENST00000327578PCM1chr817851129+ENST00000355710RETchr1043612030+43371046232254743
ENST00000327578PCM1chr817851129+ENST00000340058RETchr1043612030+28791046232128701
ENST00000325083PCM1chr817851129ENST00000355710RETchr10436120308557526643964742011
ENST00000325083PCM1chr817851129ENST00000340058RETchr10436120307099526643963481969
ENST00000519253PCM1chr817851129ENST00000355710RETchr10436120308345505425162622003
ENST00000519253PCM1chr817851129ENST00000340058RETchr10436120306887505425161361961
ENST00000524226PCM1chr817851129ENST00000355710RETchr1043612030801547245959321957
ENST00000524226PCM1chr817851129ENST00000340058RETchr1043612030655747245958061915
ENST00000327578PCM1chr817851129ENST00000355710RETchr104361203043371046232254743
ENST00000327578PCM1chr817851129ENST00000340058RETchr104361203028791046232128701

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000325083ENST00000355710PCM1chr817851129RETchr10436120300.0012801470.99871993
ENST00000325083ENST00000340058PCM1chr817851129RETchr10436120300.0029393050.9970607
ENST00000519253ENST00000355710PCM1chr817851129RETchr10436120300.000559980.99944
ENST00000519253ENST00000340058PCM1chr817851129RETchr10436120300.0030330750.9969669
ENST00000524226ENST00000355710PCM1chr817851129RETchr10436120300.0011472870.9988527
ENST00000524226ENST00000340058PCM1chr817851129RETchr10436120300.0015086190.9984914
ENST00000327578ENST00000355710PCM1chr817851129RETchr10436120300.0015422550.9984578
ENST00000327578ENST00000340058PCM1chr817851129RETchr10436120300.0067443090.9932556

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>63341_63341_1_PCM1-RET_PCM1_chr8_17851128_ENST00000325083_RET_chr10_43612031_ENST00000340058_length(amino acids)=1969AA_BP=1609
MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMS
QMSVPEQAELEKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTNPPNRETIGSAQCKELFASALS
NDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQQEPM
EEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA
VPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGL
APVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHE
NSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEE
EGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKT
QKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVF
EPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDE
EGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSEL
SYVEEKEQWQEQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQMLN
ELMRQQNQHPEKPGGKERGSSASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMNFSPLFPSNFGDFSQNISTPSEQQQPLAQNS
SGKTEYMAFPKPFESSSSIGAEKPRNKKLPEEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRRRQFDEESLES
FSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRK
NHEQLEKIIKCNRSTEISSETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEK
GENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARMREYERM
KTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEDPKWEFPRKN
LVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLR
GFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEED
SYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPD

--------------------------------------------------------------

>63341_63341_2_PCM1-RET_PCM1_chr8_17851128_ENST00000325083_RET_chr10_43612031_ENST00000355710_length(amino acids)=2011AA_BP=1609
MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMS
QMSVPEQAELEKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTNPPNRETIGSAQCKELFASALS
NDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQQEPM
EEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA
VPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGL
APVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHE
NSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEE
EGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKT
QKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVF
EPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDE
EGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSEL
SYVEEKEQWQEQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQMLN
ELMRQQNQHPEKPGGKERGSSASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMNFSPLFPSNFGDFSQNISTPSEQQQPLAQNS
SGKTEYMAFPKPFESSSSIGAEKPRNKKLPEEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRRRQFDEESLES
FSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRK
NHEQLEKIIKCNRSTEISSETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEK
GENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARMREYERM
KTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEDPKWEFPRKN
LVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLR
GFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEED
SYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPD
KRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGT

--------------------------------------------------------------

>63341_63341_3_PCM1-RET_PCM1_chr8_17851128_ENST00000327578_RET_chr10_43612031_ENST00000340058_length(amino acids)=701AA_BP=341
MASKDKTPKSKSKKRNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRKNHEQLEKIIKCNRSTEISSAHARRILQ
QSNRNACNEAPETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVN
SGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNS
NMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEDPKWEFPRKNLVLGKTLG
EGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK
VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQG
RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI

--------------------------------------------------------------

>63341_63341_4_PCM1-RET_PCM1_chr8_17851128_ENST00000327578_RET_chr10_43612031_ENST00000355710_length(amino acids)=743AA_BP=341
MASKDKTPKSKSKKRNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRKNHEQLEKIIKCNRSTEISSAHARRILQ
QSNRNACNEAPETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVN
SGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNS
NMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEDPKWEFPRKNLVLGKTLG
EGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK
VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQG
RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI
SKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYP

--------------------------------------------------------------

>63341_63341_5_PCM1-RET_PCM1_chr8_17851128_ENST00000519253_RET_chr10_43612031_ENST00000340058_length(amino acids)=1961AA_BP=1601
MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMS
QMSVPEQAELEKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTNPPNRETIGSAQCKELFASALS
NDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQQEPM
EEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA
VPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGL
APVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHE
NSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEE
EGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKT
QKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVF
EPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDE
EGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSEL
SYVEEKEQWQEQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQMLN
ELMRQQNQHPEKPGGKERGSSASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMNFSPLFPSNFGDFSQNISTPSEQQQPLAQNS
SGKTEYMAFPKPFESSSSIGAEKPRNKKLPEEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRRRQFDEESLES
FSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRK
NHEQLEKIIKCNRSTEISSETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEK
GENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARMREYERM
KTEAESNSNMRCTCRIIEDGDGAGAETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEDPKWEFPRKNLVLGKTLG
EGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK
VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQG
RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI

--------------------------------------------------------------

>63341_63341_6_PCM1-RET_PCM1_chr8_17851128_ENST00000519253_RET_chr10_43612031_ENST00000355710_length(amino acids)=2003AA_BP=1601
MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMS
QMSVPEQAELEKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTNPPNRETIGSAQCKELFASALS
NDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQQEPM
EEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA
VPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGL
APVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHE
NSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEE
EGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKT
QKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVF
EPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDE
EGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSEL
SYVEEKEQWQEQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQMLN
ELMRQQNQHPEKPGGKERGSSASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMNFSPLFPSNFGDFSQNISTPSEQQQPLAQNS
SGKTEYMAFPKPFESSSSIGAEKPRNKKLPEEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRRRQFDEESLES
FSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRK
NHEQLEKIIKCNRSTEISSETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEK
GENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARMREYERM
KTEAESNSNMRCTCRIIEDGDGAGAETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEDPKWEFPRKNLVLGKTLG
EGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK
VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQG
RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI
SKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYP

--------------------------------------------------------------

>63341_63341_7_PCM1-RET_PCM1_chr8_17851128_ENST00000524226_RET_chr10_43612031_ENST00000340058_length(amino acids)=1915AA_BP=1555
MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMS
QMSVPEQAELEKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTNPPNRETIGSAQCKELFASALS
NDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQQEPM
EEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA
VPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGL
APVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHE
NSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLADCRYNREGEQEIHVAQGEDDEEEEEEAE
EEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANK
TQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSV
FEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALD
EEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSE
LSYVEEKEQWQEQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQML
NELMRQQNQHPEKPGGKERGSSASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMNFSPLFPSNFGDFSQNISTPSEQQQPLAQN
SSGKTEYMAFPKPFESSSSIGAEKPRNKKLPEEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRRRQFDEESLE
SFSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIKTGSDFSMFEALRDTIYSEVATLISQNESRPHFLI
ELFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNAS
VLSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIP
CPRIDTQQLDRQIKAIMKEVIPFLKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFN
VLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAE
MKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP
ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAP

--------------------------------------------------------------

>63341_63341_8_PCM1-RET_PCM1_chr8_17851128_ENST00000524226_RET_chr10_43612031_ENST00000355710_length(amino acids)=1957AA_BP=1555
MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMS
QMSVPEQAELEKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTNPPNRETIGSAQCKELFASALS
NDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQQEPM
EEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA
VPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGL
APVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHE
NSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLADCRYNREGEQEIHVAQGEDDEEEEEEAE
EEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANK
TQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSV
FEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALD
EEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSE
LSYVEEKEQWQEQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQML
NELMRQQNQHPEKPGGKERGSSASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMNFSPLFPSNFGDFSQNISTPSEQQQPLAQN
SSGKTEYMAFPKPFESSSSIGAEKPRNKKLPEEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRRRQFDEESLE
SFSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIKTGSDFSMFEALRDTIYSEVATLISQNESRPHFLI
ELFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNAS
VLSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIP
CPRIDTQQLDRQIKAIMKEVIPFLKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFN
VLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAE
MKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP
ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAP

--------------------------------------------------------------

>63341_63341_9_PCM1-RET_PCM1_chr8_17851129_ENST00000325083_RET_chr10_43612030_ENST00000340058_length(amino acids)=1969AA_BP=1609
MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMS
QMSVPEQAELEKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTNPPNRETIGSAQCKELFASALS
NDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQQEPM
EEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA
VPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGL
APVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHE
NSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEE
EGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKT
QKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVF
EPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDE
EGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSEL
SYVEEKEQWQEQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQMLN
ELMRQQNQHPEKPGGKERGSSASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMNFSPLFPSNFGDFSQNISTPSEQQQPLAQNS
SGKTEYMAFPKPFESSSSIGAEKPRNKKLPEEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRRRQFDEESLES
FSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRK
NHEQLEKIIKCNRSTEISSETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEK
GENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARMREYERM
KTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEDPKWEFPRKN
LVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLR
GFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEED
SYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPD

--------------------------------------------------------------

>63341_63341_10_PCM1-RET_PCM1_chr8_17851129_ENST00000325083_RET_chr10_43612030_ENST00000355710_length(amino acids)=2011AA_BP=1609
MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMS
QMSVPEQAELEKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTNPPNRETIGSAQCKELFASALS
NDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQQEPM
EEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA
VPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGL
APVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHE
NSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEE
EGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKT
QKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVF
EPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDE
EGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSEL
SYVEEKEQWQEQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQMLN
ELMRQQNQHPEKPGGKERGSSASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMNFSPLFPSNFGDFSQNISTPSEQQQPLAQNS
SGKTEYMAFPKPFESSSSIGAEKPRNKKLPEEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRRRQFDEESLES
FSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRK
NHEQLEKIIKCNRSTEISSETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEK
GENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARMREYERM
KTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEDPKWEFPRKN
LVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLR
GFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEED
SYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPD
KRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGT

--------------------------------------------------------------

>63341_63341_11_PCM1-RET_PCM1_chr8_17851129_ENST00000327578_RET_chr10_43612030_ENST00000340058_length(amino acids)=701AA_BP=341
MASKDKTPKSKSKKRNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRKNHEQLEKIIKCNRSTEISSAHARRILQ
QSNRNACNEAPETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVN
SGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNS
NMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEDPKWEFPRKNLVLGKTLG
EGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK
VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQG
RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI

--------------------------------------------------------------

>63341_63341_12_PCM1-RET_PCM1_chr8_17851129_ENST00000327578_RET_chr10_43612030_ENST00000355710_length(amino acids)=743AA_BP=341
MASKDKTPKSKSKKRNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRKNHEQLEKIIKCNRSTEISSAHARRILQ
QSNRNACNEAPETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVN
SGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNS
NMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEDPKWEFPRKNLVLGKTLG
EGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK
VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQG
RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI
SKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYP

--------------------------------------------------------------

>63341_63341_13_PCM1-RET_PCM1_chr8_17851129_ENST00000519253_RET_chr10_43612030_ENST00000340058_length(amino acids)=1961AA_BP=1601
MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMS
QMSVPEQAELEKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTNPPNRETIGSAQCKELFASALS
NDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQQEPM
EEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA
VPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGL
APVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHE
NSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEE
EGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKT
QKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVF
EPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDE
EGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSEL
SYVEEKEQWQEQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQMLN
ELMRQQNQHPEKPGGKERGSSASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMNFSPLFPSNFGDFSQNISTPSEQQQPLAQNS
SGKTEYMAFPKPFESSSSIGAEKPRNKKLPEEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRRRQFDEESLES
FSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRK
NHEQLEKIIKCNRSTEISSETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEK
GENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARMREYERM
KTEAESNSNMRCTCRIIEDGDGAGAETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEDPKWEFPRKNLVLGKTLG
EGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK
VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQG
RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI

--------------------------------------------------------------

>63341_63341_14_PCM1-RET_PCM1_chr8_17851129_ENST00000519253_RET_chr10_43612030_ENST00000355710_length(amino acids)=2003AA_BP=1601
MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMS
QMSVPEQAELEKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTNPPNRETIGSAQCKELFASALS
NDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQQEPM
EEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA
VPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGL
APVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHE
NSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLDCRYNREGEQEIHVAQGEDDEEEEEEAEE
EGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANKT
QKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSVF
EPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDE
EGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSEL
SYVEEKEQWQEQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQMLN
ELMRQQNQHPEKPGGKERGSSASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMNFSPLFPSNFGDFSQNISTPSEQQQPLAQNS
SGKTEYMAFPKPFESSSSIGAEKPRNKKLPEEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRRRQFDEESLES
FSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRK
NHEQLEKIIKCNRSTEISSETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEK
GENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLDQALARMREYERM
KTEAESNSNMRCTCRIIEDGDGAGAETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEDPKWEFPRKNLVLGKTLG
EGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK
VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQG
RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADI
SKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYP

--------------------------------------------------------------

>63341_63341_15_PCM1-RET_PCM1_chr8_17851129_ENST00000524226_RET_chr10_43612030_ENST00000340058_length(amino acids)=1915AA_BP=1555
MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMS
QMSVPEQAELEKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTNPPNRETIGSAQCKELFASALS
NDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQQEPM
EEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA
VPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGL
APVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHE
NSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLADCRYNREGEQEIHVAQGEDDEEEEEEAE
EEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANK
TQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSV
FEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALD
EEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSE
LSYVEEKEQWQEQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQML
NELMRQQNQHPEKPGGKERGSSASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMNFSPLFPSNFGDFSQNISTPSEQQQPLAQN
SSGKTEYMAFPKPFESSSSIGAEKPRNKKLPEEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRRRQFDEESLE
SFSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIKTGSDFSMFEALRDTIYSEVATLISQNESRPHFLI
ELFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNAS
VLSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIP
CPRIDTQQLDRQIKAIMKEVIPFLKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFN
VLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAE
MKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP
ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAP

--------------------------------------------------------------

>63341_63341_16_PCM1-RET_PCM1_chr8_17851129_ENST00000524226_RET_chr10_43612030_ENST00000355710_length(amino acids)=1957AA_BP=1555
MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKKKFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMS
QMSVPEQAELEKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINTNKSKDASTNPPNRETIGSAQCKELFASALS
NDLLQNCQVSEEDGRGEPAMESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQEKSYMKFLKKILARDPQQEPM
EEIENLKKQHDLLKRMLQQQEQLRALQGRQAALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFHNQLRDSQPPA
VPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKMRVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGL
APVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRLNELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHE
NSEPVTNIRNPQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPSLADCRYNREGEQEIHVAQGEDDEEEEEEAE
EEGVSGASLSSHRSSLVDEHPEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFYPAEEDTKQNSNNTRGNANK
TQKDTGVNEKAREKFYEAKLQQQQRELKQLQEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQHETSTSKSV
FEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEHQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALD
EEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETKNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSE
LSYVEEKEQWQEQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQVHFIMHQLNQCYTQLTWQQNNVQRLKQML
NELMRQQNQHPEKPGGKERGSSASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMNFSPLFPSNFGDFSQNISTPSEQQQPLAQN
SSGKTEYMAFPKPFESSSSIGAEKPRNKKLPEEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRRRQFDEESLE
SFSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSKKRNSTQLKSRVKNIKTGSDFSMFEALRDTIYSEVATLISQNESRPHFLI
ELFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNAS
VLSVSSNFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIP
CPRIDTQQLDRQIKAIMKEVIPFLKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRDLLSEFN
VLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAE
MKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP
ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr8:17851129/chr10:43612030)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
PCM1

Q15154

RET

RTL1

FUNCTION: Required for centrosome assembly and function (PubMed:12403812, PubMed:15659651, PubMed:16943179). Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2 (PubMed:12403812, PubMed:15659651). Required to anchor microtubules to the centrosome (PubMed:12403812, PubMed:15659651). Also involved in cilium biogenesis by recruiting the BBSome, a ciliary protein complex involved in cilium biogenesis, to the centriolar satellites (PubMed:20551181, PubMed:24121310, PubMed:27979967). {ECO:0000269|PubMed:12403812, ECO:0000269|PubMed:15659651, ECO:0000269|PubMed:16943179, ECO:0000269|PubMed:20551181, ECO:0000269|PubMed:24121310, ECO:0000269|PubMed:27979967}.1358

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgenePCM1chr8:17851129chr10:43612030ENST00000325083+29391063_10891609.02025.0Coiled coilOntology_term=ECO:0000255
HgenePCM1chr8:17851129chr10:43612030ENST00000325083+29391515_15391609.02025.0Coiled coilOntology_term=ECO:0000255
HgenePCM1chr8:17851129chr10:43612030ENST00000325083+2939218_3011609.02025.0Coiled coilOntology_term=ECO:0000255
HgenePCM1chr8:17851129chr10:43612030ENST00000325083+2939400_4241609.02025.0Coiled coilOntology_term=ECO:0000255
HgenePCM1chr8:17851129chr10:43612030ENST00000325083+2939487_5431609.02025.0Coiled coilOntology_term=ECO:0000255
HgenePCM1chr8:17851129chr10:43612030ENST00000325083+2939651_6821609.02025.0Coiled coilOntology_term=ECO:0000255
HgenePCM1chr8:17851129chr10:43612030ENST00000325083+2939726_7691609.02025.0Coiled coilOntology_term=ECO:0000255
HgenePCM1chr8:17851129chr10:43612030ENST00000325083+2939824_8581609.02025.0Coiled coilOntology_term=ECO:0000255
TgeneRETchr8:17851129chr10:43612030ENST000003400581019724_1016712.01073.0DomainProtein kinase
TgeneRETchr8:17851129chr10:43612030ENST000003557101020724_1016712.01115.0DomainProtein kinase
TgeneRETchr8:17851129chr10:43612030ENST000003400581019730_738712.01073.0Nucleotide bindingATP
TgeneRETchr8:17851129chr10:43612030ENST000003557101020730_738712.01115.0Nucleotide bindingATP
TgeneRETchr8:17851129chr10:43612030ENST000003400581019805_807712.01073.0RegionNote=Inhibitors binding
TgeneRETchr8:17851129chr10:43612030ENST000003557101020805_807712.01115.0RegionNote=Inhibitors binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneRETchr8:17851129chr10:43612030ENST000003400581019168_272712.01073.0DomainCadherin
TgeneRETchr8:17851129chr10:43612030ENST000003557101020168_272712.01115.0DomainCadherin
TgeneRETchr8:17851129chr10:43612030ENST00000340058101929_635712.01073.0Topological domainExtracellular
TgeneRETchr8:17851129chr10:43612030ENST000003400581019658_1114712.01073.0Topological domainCytoplasmic
TgeneRETchr8:17851129chr10:43612030ENST00000355710102029_635712.01115.0Topological domainExtracellular
TgeneRETchr8:17851129chr10:43612030ENST000003557101020658_1114712.01115.0Topological domainCytoplasmic
TgeneRETchr8:17851129chr10:43612030ENST000003400581019636_657712.01073.0TransmembraneHelical
TgeneRETchr8:17851129chr10:43612030ENST000003557101020636_657712.01115.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (574) >>>574.pdbFusion protein BP residue: 341
CIF file (574) >>>574.cif		PCM1chr817851128+RETchr1043612031+
MASKDKTPKSKSKKRNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQ
TEEPVQAKVFSRKNHEQLEKIIKCNRSTEISSAHARRILQQSNRNACNEA
PETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYL
RQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATT
DDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLD
QALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVI
ENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEDPKWEFPR
KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRD
LLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK
VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLV
HRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIE
SLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRME
RPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAAS
TPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGRISHAFTR
701
3D view using mol* of 574 (AA BP:341)
PDB file (608) >>>608.pdbFusion protein BP residue: 341
CIF file (608) >>>608.cif		PCM1chr817851128+RETchr1043612031+
MASKDKTPKSKSKKRNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQ
TEEPVQAKVFSRKNHEQLEKIIKCNRSTEISSAHARRILQQSNRNACNEA
PETGSDFSMFEALRDTIYSEVATLISQNESRPHFLIELFHELQLLNTDYL
RQRALYALQDIVSRHISESHEKGENVKSVNSGTWIASNSELTPSESLATT
DDETFEKNFERETHKISEQNDADNASVLSVSSNFEPFATDDLGNTVIHLD
QALARMREYERMKTEAESNSNMRCTCRIIEDGDGAGAGTTVNNLEETPVI
ENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFLKEDPKWEFPR
KNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLKENASPSELRD
LLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGSLRGFLRESRK
VGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQGMQYLAEMKLV
HRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQGRIPVKWMAIE
SLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLFNLLKTGHRME
RPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVKRRDYLDLAAS
TPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKLYGMSDPNWPG
743
3D view using mol* of 608 (AA BP:341)
PDB file (1063)PCM1chr817851128+RETchr1043612031+
MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKK
KFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMSQMSVPEQAEL
EKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINT
NKSKDASTNPPNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAM
ESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQE
KSYMKFLKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQ
AALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFH
NQLRDSQPPAVPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKM
RVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGL
APVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRL
NELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRN
PQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPS
LADCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEH
PEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDF
YPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQL
QEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVN
QHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAE
HQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALD
EEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKET
KNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQW
QEQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASP
QVHFIMHQLNQCYTQLTWQQNNVQRLKQMLNELMRQQNQHPEKPGGKERG
SSASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMNFSPLFPSNF
GDFSQNISTPSEQQQPLAQNSSGKTEYMAFPKPFESSSSIGAEKPRNKKL
PEEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGR
RRQFDEESLESFSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKS
KKRNSTQLKSRVKNIKTGSDFSMFEALRDTIYSEVATLISQNESRPHFLI
ELFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIA
SNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEP
FATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAG
AGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEV
IPFLKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAV
KMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYA
KYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQ
ISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVK
RSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP
ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEK
MMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWI
1915
PDB file (1076)PCM1chr817851128+RETchr1043612031+
MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKK
KFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMSQMSVPEQAEL
EKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINT
NKSKDASTNPPNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAM
ESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQE
KSYMKFLKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQ
AALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFH
NQLRDSQPPAVPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKM
RVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGL
APVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRL
NELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRN
PQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPS
LADCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEH
PEDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDF
YPAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQL
QEERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVN
QHETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAE
HQRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALD
EEGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKET
KNRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQW
QEQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASP
QVHFIMHQLNQCYTQLTWQQNNVQRLKQMLNELMRQQNQHPEKPGGKERG
SSASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMNFSPLFPSNF
GDFSQNISTPSEQQQPLAQNSSGKTEYMAFPKPFESSSSIGAEKPRNKKL
PEEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGR
RRQFDEESLESFSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKS
KKRNSTQLKSRVKNIKTGSDFSMFEALRDTIYSEVATLISQNESRPHFLI
ELFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSGTWIA
SNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSSNFEP
FATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDGDGAG
AGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEV
IPFLKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAV
KMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYA
KYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQ
ISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVK
RSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPP
ERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEK
MMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWI
ENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAK
1957
PDB file (1078)PCM1chr817851128+RETchr1043612031+
MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKK
KFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMSQMSVPEQAEL
EKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINT
NKSKDASTNPPNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAM
ESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQE
KSYMKFLKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQ
AALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFH
NQLRDSQPPAVPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKM
RVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGL
APVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRL
NELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRN
PQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPS
LDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHP
EDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFY
PAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQ
EERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQ
HETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEH
QRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDE
EGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETK
NRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQWQ
EQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQ
VHFIMHQLNQCYTQLTWQQNNVQRLKQMLNELMRQQNQHPEKPGGKERGS
SASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMNFSPLFPSNFG
DFSQNISTPSEQQQPLAQNSSGKTEYMAFPKPFESSSSIGAEKPRNKKLP
EEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRR
RQFDEESLESFSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSK
KRNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRK
NHEQLEKIIKCNRSTEISSETGSDFSMFEALRDTIYSEVATLISQNESRP
HFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSG
TWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSS
NFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDG
DGAGAETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFL
KEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK
ENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS
LRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQG
MQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQG
RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLF
NLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVK
RRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKL
1961
PDB file (1080)PCM1chr817851128+RETchr1043612031+
MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKK
KFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMSQMSVPEQAEL
EKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINT
NKSKDASTNPPNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAM
ESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQE
KSYMKFLKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQ
AALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFH
NQLRDSQPPAVPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKM
RVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGL
APVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRL
NELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRN
PQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPS
LDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHP
EDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFY
PAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQ
EERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQ
HETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEH
QRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDE
EGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETK
NRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQWQ
EQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQ
VHFIMHQLNQCYTQLTWQQNNVQRLKQMLNELMRQQNQHPEKPGGKERGS
SASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMNFSPLFPSNFG
DFSQNISTPSEQQQPLAQNSSGKTEYMAFPKPFESSSSIGAEKPRNKKLP
EEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRR
RQFDEESLESFSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSK
KRNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRK
NHEQLEKIIKCNRSTEISSETGSDFSMFEALRDTIYSEVATLISQNESRP
HFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSG
TWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSS
NFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDG
DGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAI
MKEVIPFLKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYT
TVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLI
VEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEED
SYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYP
GIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISK
DLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALP
1969
PDB file (1084) >>>1084.pdbFusion protein BP residue: 1601
CIF file (1084) >>>1084.cif		PCM1chr817851128+RETchr1043612031+
MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKK
KFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMSQMSVPEQAEL
EKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINT
NKSKDASTNPPNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAM
ESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQE
KSYMKFLKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQ
AALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFH
NQLRDSQPPAVPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKM
RVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGL
APVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRL
NELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRN
PQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPS
LDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHP
EDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFY
PAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQ
EERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQ
HETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEH
QRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDE
EGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETK
NRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQWQ
EQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQ
VHFIMHQLNQCYTQLTWQQNNVQRLKQMLNELMRQQNQHPEKPGGKERGS
SASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMNFSPLFPSNFG
DFSQNISTPSEQQQPLAQNSSGKTEYMAFPKPFESSSSIGAEKPRNKKLP
EEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRR
RQFDEESLESFSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSK
KRNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRK
NHEQLEKIIKCNRSTEISSETGSDFSMFEALRDTIYSEVATLISQNESRP
HFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSG
TWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSS
NFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDG
DGAGAETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAIMKEVIPFL
KEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYTTVAVKMLK
ENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLIVEYAKYGS
LRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLISFAWQISQG
MQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEEDSYVKRSQG
RIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYPGIPPERLF
NLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISKDLEKMMVK
RRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALPSTWIENKL
YGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSPSAAKLMDT
2003
3D view using mol* of 1084 (AA BP:1601)
PDB file (1086) >>>1086.pdbFusion protein BP residue: 1609
CIF file (1086) >>>1086.cif		PCM1chr817851128+RETchr1043612031+
MATGGGPFEDGMNDQDLPNWSNENVDDRLNNMDWGAQQKKANRSSEKNKK
KFGVESDKRVTNDISPESSPGVGRRRTKTPHTFPHSRYMSQMSVPEQAEL
EKLKQRINFSDLDQRSIGSDSQGRATAANNKRQLSENRKPFNFLPMQINT
NKSKDASTNPPNRETIGSAQCKELFASALSNDLLQNCQVSEEDGRGEPAM
ESSQIVSRLVQIRDYITKASSMREDLVEKNERSANVERLTHLIDHLKEQE
KSYMKFLKKILARDPQQEPMEEIENLKKQHDLLKRMLQQQEQLRALQGRQ
AALLALQHKAEQAIAVMDDSVVAETAGSLSGVSITSELNEELNDLIQRFH
NQLRDSQPPAVPDNRRQAESLSLTREVSQSRKPSASERLPDEKVELFSKM
RVLQEKKQKMDKLLGELHTLRDQHLNNSSSSPQRSVDQRSTSAPSASVGL
APVVNGESNSLTSSVPYPTASLVSQNESENEGHLNPSEKLQKLNEVRKRL
NELRELVHYYEQTSDMMTDAVNENRKDEETEESEYDSEHENSEPVTNIRN
PQVASTWNEVNSHSNAQCVSNNRDGRTVNSNCEINNRSAANIRALNMPPS
LDCRYNREGEQEIHVAQGEDDEEEEEEAEEEGVSGASLSSHRSSLVDEHP
EDAEFEQKINRLMAAKQKLRQLQDLVAMVQDDDAAQGVISASASNLDDFY
PAEEDTKQNSNNTRGNANKTQKDTGVNEKAREKFYEAKLQQQQRELKQLQ
EERKKLIDIQEKIQALQTACPDLQLSAASVGNCPTKKYMPAVTSTPTVNQ
HETSTSKSVFEPEDSSIVDNELWSEMRRHEMLREELRQRRKQLEALMAEH
QRRQGLAETASPVAVSLRSDGSENLCTPQQSRTEKTMATWGGSTQCALDE
EGDEDGYLSEGIVRTDEEEEEEQDASSNDNFSVCPSNSVNHNSYNGKETK
NRWKNNCPFSADENYRPLAKTRQQNISMQRQENLRWVSELSYVEEKEQWQ
EQINQLKKQLDFSVSICQTLMQDQQTLSCLLQTLLTGPYSVMPSNVASPQ
VHFIMHQLNQCYTQLTWQQNNVQRLKQMLNELMRQQNQHPEKPGGKERGS
SASHPPSPSLFCPFSFPTQPVNLFNIPGFTNFSSFAPGMNFSPLFPSNFG
DFSQNISTPSEQQQPLAQNSSGKTEYMAFPKPFESSSSIGAEKPRNKKLP
EEEVESSRTPWLYEQEGEVEKPFIKTGFSVSVEKSTSSNRKNQLDTNGRR
RQFDEESLESFSSMPDPVDPTTVTKTFKTRKASAQASLASKDKTPKSKSK
KRNSTQLKSRVKNIRYESASMSSTCEPCKSRNRHSAQTEEPVQAKVFSRK
NHEQLEKIIKCNRSTEISSETGSDFSMFEALRDTIYSEVATLISQNESRP
HFLIELFHELQLLNTDYLRQRALYALQDIVSRHISESHEKGENVKSVNSG
TWIASNSELTPSESLATTDDETFEKNFERETHKISEQNDADNASVLSVSS
NFEPFATDDLGNTVIHLDQALARMREYERMKTEAESNSNMRCTCRIIEDG
DGAGAGTTVNNLEETPVIENRSSQQPVSEVSTIPCPRIDTQQLDRQIKAI
MKEVIPFLKEDPKWEFPRKNLVLGKTLGEGEFGKVVKATAFHLKGRAGYT
TVAVKMLKENASPSELRDLLSEFNVLKQVNHPHVIKLYGACSQDGPLLLI
VEYAKYGSLRGFLRESRKVGPGYLGSGGSRNSSSLDHPDERALTMGDLIS
FAWQISQGMQYLAEMKLVHRDLAARNILVAEGRKMKISDFGLSRDVYEED
SYVKRSQGRIPVKWMAIESLFDHIYTTQSDVWSFGVLLWEIVTLGGNPYP
GIPPERLFNLLKTGHRMERPDNCSEEMYRLMLQCWKQEPDKRPVFADISK
DLEKMMVKRRDYLDLAASTPSDSLIYDDGLSEEETPLVDCNNAPLPRALP
STWIENKLYGMSDPNWPGESPVPLTRADGTNTGFPRYPNDSVYANWMLSP
2011
3D view using mol* of 1086 (AA BP:1609)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
PCM1_pLDDT.png
all structure
all structure
RET_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
PCM1_RET_574_pLDDT.png (AA BP:341)
all structure
PCM1_RET_574_pLDDT_and_active_sites.png (AA BP:341)
all structure
PCM1_RET_574_violinplot.png (AA BP:341)
all structure
PCM1_RET_608_pLDDT.png (AA BP:341)
all structure
PCM1_RET_608_pLDDT_and_active_sites.png (AA BP:341)
all structure
PCM1_RET_608_violinplot.png (AA BP:341)
all structure
PCM1_RET_1084_pLDDT.png (AA BP:1601)
all structure
PCM1_RET_1084_pLDDT_and_active_sites.png (AA BP:1601)
all structure
PCM1_RET_1084_violinplot.png (AA BP:1601)
all structure
PCM1_RET_1086_pLDDT.png (AA BP:1609)
all structure
PCM1_RET_1086_pLDDT_and_active_sites.png (AA BP:1609)
all structure
PCM1_RET_1086_violinplot.png (AA BP:1609)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
PCM1_RET_574.png
all structure
PCM1_RET_608.png
all structure
PCM1_RET_1086.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
5741.1041121.159294.2940.4890.7660.971.7010.742.2980.897Chain A: 359,360,361,362,363,364,365,366,367,385,3
87,404,408,417,431,433,434,435,436,437,439,440,507
,508,510,520,521
6081.1821711.291469.910.4550.7680.9872.9170.3388.6261.161Chain A: 109,110,113,114,116,117,118,120,121,124,1
35,138,139,142,143,145,148,151,152,155,156,158,159
,161,162,325,328,329,332
10631.1622781.243546.7420.420.7931.0262.7430.535.1761.636Chain A: 1324,1327,1328,1330,1331,1332,1334,1335,1
338,1339,1342,1344,1345,1348,1349,1350,1352,1353,1
356,1357,1362,1365,1366,1369,1370,1372,1373,1375,1
376,1378,1379,1470,1473,1474,1476,1477,1480,1547
10761.0732381.15461.3350.5670.6880.8781.6930.6232.7191.307Chain A: 1327,1331,1334,1335,1337,1338,1341,1342,1
344,1345,1348,1349,1352,1353,1356,1369,1370,1372,1
373,1375,1376,1379,1380,1382,1383,1384,1387,1529,1
530,1531,1532,1533,1534,1535,1536,1538,1539,1540,1
543
10781.0696591.1392440.1020.590.6940.8491.2440.6681.8631.062Chain A: 311,314,317,318,335,336,338,339,342,343,3
46,1359,1374,1375,1377,1378,1380,1381,1382,1384,13
85,1388,1389,1391,1392,1395,1396,1397,1398,1399,14
02,1403,1406,1407,1409,1410,1411,1413,1414,1415,14
16,1418,1419,1420,1421,1422,1423,1424,1425,1426,14
27,1429,1430,1433,1434,1510,1511,1512,1513,1514,15
15,1516,1517,1518,1519,1520,1522,1523,1524,1525,15
26,1529,1530,1580,1581,1582,1583,1584,1585,1586,15
87,1588,1589,1590,1592,1593,1594,1595,1596,1597,15
99,1600,1601,1602,1603,1604,1658,1659,1662,1665,16
66,1669,1684,1685,1689
10801.1083281.1811435.4550.5390.7370.9391.5880.6152.5811.349Chain A: 1385,1388,1389,1392,1396,1398,1399,1402,1
403,1406,1407,1409,1410,1412,1413,1414,1415,1418,1
420,1421,1422,1423,1424,1425,1426,1427,1429,1430,1
433,1434,1587,1588,1589,1590,1592,1593,1594,1596,1
597,1600,1601,1604,1605,1607,1608,1609,1610,1611,1
614,1615,1657,1661,1662,1663,1666,1670,1673,1674,1
677,1690,1692,1693,1694,1695,1696,1697
10841.1591591.273535.7660.4890.7290.9632.7140.3198.5064.563Chain A: 1352,1355,1356,1358,1359,1362,1377,1380,1
381,1384,1385,1388,1389,1391,1392,1393,1403,1406,1
407,1410,1423,1426,1427,1430,1431,1433,1434
10841.1591591.273535.7660.4890.7290.9632.7140.3198.5064.563Chain A: 1352,1355,1356,1358,1359,1362,1377,1380,1
381,1384,1385,1388,1389,1391,1392,1393,1403,1406,1
407,1410,1423,1426,1427,1430,1431,1433,1434
10861.0551131.095275.0860.5310.730.9111.1860.8671.3691.561Chain A: 1625,1627,1628,1629,1630,1631,1632,1633,1
635,1653,1655,1672,1676,1685,1699,1701,1702,1703,1
704,1705,1706,1707,1708,1711,1775,1776,1778,1788,1
789
10861.0551131.095275.0860.5310.730.9111.1860.8671.3691.561Chain A: 1625,1627,1628,1629,1630,1631,1632,1633,1
635,1653,1655,1672,1676,1685,1699,1701,1702,1703,1
704,1705,1706,1707,1708,1711,1775,1776,1778,1788,1
789

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore
574ZINC000150338698DB00314Capreomycin-5.82562-6.33792
574ZINC000008214418DB09135Ioxilan-6.30589-6.30589
574ZINC000003830944DB01362Iohexol-6.24962-6.24962
574ZINC000049637509DB06636Isavuconazonium-4.21336-6.11806
574ZINC000085540215DB09135Ioxilan-5.86054-5.86054
574ZINC000085537017DB06441Cangrelor-5.80015-5.81415
574ZINC000000388081DB05381Histamine-5.3292-5.7842
574ZINC000003830943DB01362Iohexol-5.71356-5.71356
574ZINC000148723177DB12267Brigatinib-3.41672-5.66422
574ZINC000008143864DB09134Ioversol-5.59641-5.59641
574ZINC000003830946DB01362Iohexol-5.53147-5.53147
574ZINC000008214629DB06804Nonoxynol-9-5.51171-5.51171
574ZINC000000895457DB08847Hydroxyproline-5.50114-5.50114
574ZINC000150588351DB11574Elbasvir-4.2298-5.4734
574ZINC000096006023DB06590Ceftaroline fosamil-4.89702-5.44212
574ZINC000253632968DB06290Simeprevir-5.35706-5.36366
574ZINC000000057624DB00368Norepinephrine-5.31643-5.33393
574ZINC000001530775DB00738Pentamidine-5.3304-5.3304
574ZINC000029571072DB06636Isavuconazonium-4.85984-5.29184
574ZINC000004097343DB01167Itraconazole-5.24995-5.27155

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group
ZINC000150338698DB00314CapreomycinSmall molecule[H][C@@]1(CCN=C(N)N1)[C@]1([H])NC(=O)C(NC(=O)[C@H](CNC(=O)C[C@@H](N)CCCN)NC(=O)[C@H](C)NC(=O)[C@@H](N)CNC1=O)=C/NC(N)=O.[H][C@@]1(CCN=C(N)N1)[C@]1([H])NC(=O)C(NC(=O)[C@H](CNC(=O)C[C@@H](N)CCCN)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CNC1=O)=C/NC(N)=OApproved
ZINC000008214418DB09135IoxilanSmall moleculeCC(=O)N(CC(O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCCO)=C1IApproved
ZINC000049637509DB06636IsavuconazoniumSmall molecule[H]C(C)(OC(=O)N(C)C1=C(COC(=O)CNC)C=CC=N1)[N+]1=CN(C[C@](O)(C2=C(F)C=CC(F)=C2)[C@@]([H])(C)C2=NC(=CS2)C2=CC=C(C=C2)C#N)N=C1Approved|Investigational
ZINC000085537017DB06441CangrelorSmall moleculeCSCCNC1=C2N=CN([C@@H]3O[C@H](COP(O)(=O)OP(O)(=O)C(Cl)(Cl)P(O)(O)=O)[C@@H](O)[C@H]3O)C2=NC(SCCC(F)(F)F)=N1Approved
ZINC000000388081DB05381HistamineSmall moleculeNCCC1=CNC=N1Approved|Investigational
ZINC000148723177DB12267BrigatinibSmall moleculeCOC1=CC(=CC=C1NC1=NC=C(Cl)C(NC2=CC=CC=C2P(C)(C)=O)=N1)N1CCC(CC1)N1CCN(C)CC1Approved|Investigational
ZINC000008143864DB09134IoversolSmall moleculeOCCN(C(=O)CO)C1=C(I)C(C(=O)NCC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1IApproved
ZINC000008214629DB06804Nonoxynol-9Small moleculeCCCCCCCCCC1=CC=C(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)C=C1Approved|Withdrawn
ZINC000000895457DB08847HydroxyprolineSmall moleculeO[C@H]1CN[C@@H](C1)C(O)=OExperimental
ZINC000150588351DB11574ElbasvirSmall molecule[H][C@]1(CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C)C1=NC=C(N1)C1=CC2=C(C=C1)N1[C@@H](OC3=C(C=CC(=C3)C3=CN=C(N3)[C@]3([H])CCCN3C(=O)[C@@H](NC(=O)OC)C(C)C)C1=C2)C1=CC=CC=C1Approved
ZINC000253632968DB06290SimeprevirSmall molecule[H][C@]12C[C@]1(NC(=O)[C@]1([H])C[C@H](C[C@@]1([H])C(=O)N(C)CCCCC=C/2)OC1=CC(=NC2=C1C=CC(OC)=C2C)C1=NC(=CS1)C(C)C)C(=O)NS(=O)(=O)C1CC1Approved
ZINC000000057624DB00368NorepinephrineSmall moleculeNC[C@H](O)C1=CC(O)=C(O)C=C1Approved
ZINC000001530775DB00738PentamidineSmall moleculeNC(=N)C1=CC=C(OCCCCCOC2=CC=C(C=C2)C(N)=N)C=C1Approved|Investigational

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three
ZINC000150338698668.7126.387969.107438.187507.60723.31401886.3581014.78.0851032
ZINC000150338698668.7121.971011.384430.014557.99123.37901920.751014.78.0631032
ZINC000008214418791.1161.945763.111318.983317.0489.77117.311418.936716.59.19911.20931
ZINC000003830944821.1433.746800.499332.755343.8249.483114.4361490.981818.29.7011031
ZINC000085540215791.11610.896769.61332.376308.4229.811119.0021424.341716.59.57913.14231
ZINC000085537017776.3537.43927.054287.655393.58554.42191.3941783.369320.68.4621031
ZINC000085537017776.3535.036918.307262.294312.53251.82291.6611775.566320.68.6031031
ZINC000000388081111.1464.788315.23192.229118.535104.4680466.77632.59.295265.25300
ZINC000000388081111.1465.535313.53290.818116.688106.0260465.559339.188264.91700
ZINC000000388081111.1464.794316.56991.628116.549108.3930470.46832.59.292265.82300
ZINC000003830943821.1432.11797.152329.149341.9798.796117.2271489.14818.29.3561031
ZINC000148723177584.15.166976.551585.47160.71276.12754.2431801.327112.757.731378.04711
ZINC000148723177584.15.799978.721539.73584.801306.93847.2471814.982112.757.869273.55111
ZINC000008143864807.1165.478759.618304.239335.9096.136113.3331427.748818.29.2111031
ZINC000003830946821.1435.327787.47294369.2089.789114.4741488.253818.29.6311031
ZINC000008214629616.8314.1251348.3751161.40155.343131.63202307.973116.059.02110022
ZINC000000895457131.1317.237313.333137.57175.76300472.62835.210.259230.29901
ZINC000150588351882.036.5721345.74717.517186.345441.87802635.9722.513.258.001168.97331
ZINC000150588351882.0315.5811298.014670.728196.39430.89602598.6552.513.258.107165.89131
ZINC000150588351882.037.6941389.327750.107173.462465.75802673.8482.513.258.124173.08531
ZINC000150588351882.032.2191373.023721.483195.055456.48502655.1922.513.258.091168.49731
ZINC000150588351882.0313.7611347.364706.26205.501435.60302635.2572.513.258.253164.82431
ZINC000150588351882.036.9221403.807740.212182.531481.06402678.7442.513.258.307171.99131
ZINC000150588351882.0313.991367.982729.766188.685449.53102678.6732.513.257.973170.20832
ZINC000150588351882.0310.6561391.126719.587194.166477.37302673.6242.513.257.937169.24432
ZINC000150588351882.038.2331375.056718.117197.908459.03202655.632.513.257.962167.78732
ZINC000253632968749.9396.9571148.652820.732134.162154.91538.8422228.6291.2513.758.419162.52532
ZINC000253632968749.93911.1351103.653772.655146.278144.58240.1382184.3831.2513.758.499157.80432
ZINC000253632968749.9399.2981114.226794.485125.878154.69239.172200.51.2513.758.41163.80632
ZINC000253632968749.9398.171081.392774.076143.601146.31117.4042179.1541.2513.758.604161.00632
ZINC000000057624169.183.43375.22557.715204.72112.790592.16854.28.952246.79100
ZINC000000057624169.182.409366.47858.999201.357106.1220584.36954.28.77247.30600
ZINC000001530775340.4248.052698.011179.111218.326300.57401179.9564.58.662263.34410
ZINC000004097343705.6427.1811151.617480.95696.274452.325122.0622102.052010.258.242177.79231
ZINC000004097343705.6422.8981052.809447.53582.593408.226114.4552020.51010.258.414179.55331


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity
ZINC000150338698NCCC[C@H](N)CC(=O)NC[C@@H]1NC(=O)[C@H](CO)NC(=O)[C@@H](N)CNC(=O)[C@H]([C@H]2CCN=C(N)N2)NC(=O)/C(=CNC(N)=O)NC1=O0.0088866960.175052227
ZINC000008214418CC(=O)N(C[C@H](O)CO)c1c(I)c(C(=O)NCCO)c(I)c(C(=O)NC[C@H](O)CO)c1I0.0550759120.216199147
ZINC000003830944CC(=O)N(C[C@@H](O)CO)c1c(I)c(C(=O)NC[C@H](O)CO)c(I)c(C(=O)NC[C@H](O)CO)c1I0.0423322430.211666342
ZINC000049637509CNCC(=O)OCc1cccnc1N(C)C(=O)O[C@@H](C)[n+]1cnn(C[C@](O)(c2cc(F)ccc2F)[C@@H](C)c2nc(-c3ccc(C#N)cc3)cs2)c10.0254160270.235213823
ZINC000085540215CC(=O)N(C[C@@H](O)CO)c1c(I)c(C(=O)NCCO)c(I)c(C(=O)NC[C@H](O)CO)c1I0.0550759120.216199147
ZINC000085537017CSCCNc1nc(SCCC(F)(F)F)nc2c1ncn2[C@@H]1O[C@H](CO[P@@](=O)(O)O[P@](=O)(O)C(Cl)(Cl)P(=O)(O)O)[C@@H](O)[C@H]1O0.0178895410.259362736
ZINC000000388081NCCc1cnc[nH]10.2129447840.352067312
ZINC000003830943CC(=O)N(C[C@H](O)CO)c1c(I)c(C(=O)NC[C@H](O)CO)c(I)c(C(=O)NC[C@H](O)CO)c1I0.0423322430.211666342
ZINC000148723177COc1cc(N2CCC(N3CCN(C)CC3)CC2)ccc1Nc1ncc(Cl)c(Nc2ccccc2P(C)(C)=O)n10.1425535560.1573686
ZINC000008143864O=C(NC[C@H](O)CO)c1c(I)c(C(=O)NC[C@H](O)CO)c(I)c(N(CCO)C(=O)CO)c1I0.0517806690.23149478
ZINC000003830946CC(=O)N(C[C@@H](O)CO)c1c(I)c(C(=O)NC[C@H](O)CO)c(I)c(C(=O)NC[C@@H](O)CO)c1I0.0423322430.211666342
ZINC000008214629CCCCCCCCCc1ccc(OCCOCCOCCOCCOCCOCCOCCOCCOCCO)cc10.1978866590.439158961
ZINC000000895457O=C(O)[C@H]1C[C@H](O)CN10.0992782670.470163896
ZINC000150588351COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(-c2ccc3c(c2)O[C@@H](c2ccccc2)n2c-3cc3cc(-c4c[nH]c([C@@H]5CCCN5C(=O)[C@@H](NC(=O)OC)C(C)C)n4)ccc32)c[nH]1)C(C)C0.0158759170.217012798
ZINC000096006023CCO/N=C(/C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(Sc3nc(-c4cc[n+](C)cc4)cs3)CS[C@H]12)c1nsc(NP(=O)(O)O)n10.0272335820.191312451
ZINC000253632968COc1ccc2c(O[C@@H]3C[C@H]4C(=O)N[C@]5(C(=O)NS(=O)(=O)C6CC6)C[C@H]5C=CCCCCN(C)C(=O)[C@@H]4C3)cc(-c3nc(C(C)C)cs3)nc2c1C0.0148452150.273382605
ZINC000000057624NC[C@H](O)c1ccc(O)c(O)c10.187147430.309816979
ZINC000001530775N=C(N)c1ccc(OCCCCCOc2ccc(C(=N)N)cc2)cc10.370358210.393925825
ZINC000029571072CNCC(=O)OCc1cccnc1N(C)C(=O)O[C@H](C)[n+]1cnn(C[C@](O)(c2cc(F)ccc2F)[C@@H](C)c2nc(-c3ccc(C#N)cc3)cs2)c10.0254160270.235213823
ZINC000004097343CC[C@@H](C)n1ncn(-c2ccc(N3CCN(c4ccc(OC[C@H]5CO[C@](Cn6cncn6)(c6ccc(Cl)cc6Cl)O5)cc4)CC3)cc2)c1=O0.0443632860.444547752


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
PCM1BBS4, KRT15, ING5, KIAA0368, KRT19, CCDC53, ABI2, EXOC8, EPS8, CEP72, PCNT, HAP1, Haus4, Cep170, Haus1, Ndc80, Cep131, EWSR1, HNRNPUL1, CLTC, MIB1, FUS, CEP131, PPIB, SIRT7, NEURL4, PAN2, CASK, E2F4, YWHAQ, LATS2, SAV1, CEP250, HAUS2, OBSL1, CCDC8, CSPP1, CCDC183, SLC25A41, SSFA2, RASSF8, RASSF7, IFT81, NTRK1, BTRC, MED4, HERC2, AHI1, CEP162, RPGRIP1L, CC2D2A, CEP128, LCA5, OFD1, CCDC138, CEP170, PIBF1, SSX2IP, WRAP73, HAUS1, HAUS4, KIAA0753, CCDC77, CCNB2, CEP350, CEP95, CSNK1A1, DSP, KIF20A, LUZP1, MCM10, MCRS1, MPRIP, NDC80, SMARCD2, TPGS1, SUPT5H, SSBP1, KIF7, SKA1, TSPYL1, SREK1IP1, CSNK1D, IFT172, CEP55, IFT20, CCDC14, HMMR, CFAP97, IPO5, KCTD12, SNRPE, SPICE1, ABCD3, ACOT9, ATP5L, CAMSAP1, CC2D1A, CCDC66, CEP120, CKAP2, FGFR1OP, HAUS3, HAUS5, HAUS6, HAUS7, HAUS8, IDH3B, IFT57, IFT74, NCKAP5L, RAE1, STAU1, TP53BP2, TTK, TXLNA, TXLNG, TBC1D31, WDR83, XRN1, ZNF280C, ACTR2, ANKRD26, BAIAP2, BICD1, BICD2, BTF3, C11orf49, KNSTRN, C2CD3, CAMSAP2, CCDC112, CCDC18, CCDC22, CCDC85C, CCDC92, CCNB1, CCP110, CDC123, CEP164, CEP192, CEP57L1, CEP63, CEP85, CEP89, CEP97, CKAP2L, CNOT10, COMMD2, COMMD4, CSNK1E, DAPK3, DIAPH3, ERC1, EXOC4, FOPNL, GNAO1, GPATCH1, IBTK, IQCB1, KIAA1328, KIF14, LRRC49, LRRCC1, MAGED1, MAP7D3, MED29, MIS18A, MIS18BP1, MOB4, MPHOSPH9, MYO9A, NAV1, NEDD1, NME7, NOL11, NUF2, ODF2L, ODF2, PCBP3, PKN2, PLK1, KIZ, PPP1R9B, IFT22, RRM2, SCLT1, SDCCAG3, SECISBP2, SMG5, SMG7, SPATA24, SPATS2, SPC24, SRGAP2, STRN4, TANC1, TCHP, TEX9, TNIP1, TRAF3IP1, TTC12, TTF2, TTLL4, TTLL5, CEP104, CEP290, CEP152, CEP135, CNTRL, FBF1, NINL, NIN, POC5, SASS6, RPGRIP1, STIL, CENPJ, CENPE, PPP2CA, PRKAR2B, DYNLL1, MAPRE1, SLAIN2, CEP170P1, PPP2R3C, Cit, Nedd1, Prkacb, Prkar2a, Cetn2, Ppp2r1a, Uso1, Ccdc77, Dlg5, Lrrcc1, Cep55, Cep72, Fgfr1op, Immt, Sdccag8, Myh10, Cep152, Ccp110, Cep78, Bag2, Cdk5rap2, Cep290, Mib1, Cep120, Cenpe, Cep104, Ankrd26, Cep135, YWHAE, YWHAZ, MTMR7, C6orf118, BIN3, CCDC172, LPXN, FAM81B, COG5, ING2, CCDC65, LCA5L, CCDC40, DKK3, NECAB2, ATG14, TSC1, RNF168, HNRNPL, LNX1, EGLN3, GABARAP, PRC1, AKAP9, KLC4, PRKCI, FXR2, CDC42, KLC1, DDX23, RPA2, RBM5, USP9X, RNF31, ABI1, TFIP11, DDIT3, CCHCR1, RINT1, GOLGA2, KRT24, FAM188B, SPDL1, MYO6, ESR2, UBR7, TUBG1, EEA1, KIAA1429, ATG16L1, HOOK3, APEX1, SCARB2, VMP1, ETAA1, MTM1, TPTE2, CYLD, SPATA2, nsp2ab, RALBP1, CYTH4, FAM81A, PINK1, ACTB, nsp12, nsp16, nsp2, nsp7, ORF6, RQCD1, FAM120C, BRD1, SP110, SREBF2, nsp13ab, NDN, NUPR1, FAM184A, YBEY, DDX58, TRIM37, AR, ISG15, GOLGA1, LATS1, CAMSAP3, CCDC57, CDK5RAP2, CEP112, CEP295, CEP85L, CNTLN, CNTROB, DLG5, FAM184B, GAS8, GCC2, KIAA0586, KIAA1217, KIAA1671, KIF15, KIF1B, NYNRIN, PDZRN3, PLEKHG1, PPP1R13B, RGPD6, SRGAP1, TRIOBP, TRO, TTC3, WDR90, CEP170B, SPAG5, SEPT10, NAA40, VPS33B, KRT2, FAM9B, KRT86, KRT83, DISC1, DUSP16, FILIP1, NEBL, KRT73, SNAP91, KRT38, MAP7, KRT81, CCDC96, STX10, S100A2, KRT16, BFSP1, GOLGA6A, KRT14, C9orf16, USP28, KRT1, CETN1, REPIN1, TXNDC11, STRN, CCNB1IP1, ZNF24, LSM2, LARP4, ZNF830, PRPF6, DENND1A, INTS4, MORF4L1, PPIE, ALG13, GRN, NDUFA9, KAT5, Uba1, 2700060E02Rik, Bbs5, Fez2, Klc4, CDK1, TAX1BP1, GLI2, SPZ1, RB1CC1, MAGEL2,
RETSTAT3, DOK6, DOK5, SRC, SHC1, PTPRF, DOK2, DOK4, DOK1, GRB2, CRK, PLCG1, PDLIM7, GRB7, FRS2, NRTN, GFRA1, GRB10, IKBKG, MCRS1, CBL, CBLC, RET, HSP90AA1, NOTCH2NL, NOTCH3, AIP, EGFR, NTRK1, ZBTB48, HNRNPD, SORT1, SYNCRIP, SGTB, BAG6, HIST1H3A, KYNU, TXNL4A, ZCCHC8, ICE2, MAPK3, PTK2, MAPK1, PTPRR, DUSP26, Shc1, PIK3R1, FBXO7, NEDD4, SHANK2, LRRK1, PTK6, CTNNB1, SHC4, ERBB2, ADAM10, SPINT2, PCDH7, LRIG2, APP, GDNF, IGF1R, CLU, EPCAM, CDH2, TGFBR1, PTK7, FAT1, DHCR24, SMN1, PCDH19, NCSTN, CERS2, CHP1, FANCD2, ITM2C, SEL1L, PCDHGB5, CKB, NRP1, PLXNB2, NCK2, CTNND1, TULP3, PTPN1, NF2, CRKL, CAMLG, NUMB, BASP1, ROR2, NOTCH2, PTPN13, ANK3, RAB3GAP1, PEA15, LLGL1, GPRIN3, RAPH1, MARK2, CYFIP1, ARC, GPRIN1, ANKLE2, VRK2, MIB1, PHACTR4, UNC5B, TMEM57, SYAP1, FAF2, ERBB2IP, FAM129B, KIAA1715, PEAK1, VANGL2, BAIAP2, EPN1, NUMBL, PRKAR2A, GAB1, PTPRA, DDX39A, TIMP1, EPHB4, MANEA, SRY, RABAC1, LEMD3, TMEM214, PDZD8, GPR50, SMIM5, RNF149, SDF2L1, BMPR1A, PLEKHH3, ACVR2A,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
PCM1all structure
RETall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgenePCM1chr8:17851129chr10:43612030ENST00000325083+29391913_20241609.02025.0BBS4
HgenePCM1chr8:17851129chr10:43612030ENST00000325083+29391279_17991609.02025.0HAP1


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Related Drugs to PCM1-RET


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to PCM1-RET


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
PCM1RETLung AdenocarcinomaMyCancerGenome
PCM1RETBreast Invasive Ductal CarcinomaMyCancerGenome
PCM1RETThyroid Gland Papillary CarcinomaMyCancerGenome
PCM1RETAdenocarcinoma Of Unknown PrimaryMyCancerGenome
PCM1RETBladder Urothelial CarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgenePCM1C0036341Schizophrenia1CTD_human
HgenePCM1C0238463Papillary thyroid carcinoma1ORPHANET
TgeneRETC1833921Familial medullary thyroid carcinoma23CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC3888239HIRSCHSPRUNG DISEASE, SUSCEPTIBILITY TO, 116GENOMICS_ENGLAND;UNIPROT
TgeneRETC0025268Multiple Endocrine Neoplasia Type 2a15CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC1708353Hereditary Paraganglioma-Pheochromocytoma Syndrome12CLINGEN
TgeneRETC0025269Multiple Endocrine Neoplasia Type 2b10CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
TgeneRETC0238463Papillary thyroid carcinoma3CTD_human;ORPHANET
TgeneRETC1275808Congenital central hypoventilation3CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRETC1859049CCHS WITH HIRSCHSPRUNG DISEASE3CTD_human;ORPHANET
TgeneRETC0009402Colorectal Carcinoma2CTD_human;UNIPROT
TgeneRETC0009404Colorectal Neoplasms2CTD_human
TgeneRETC0019569Hirschsprung Disease2CTD_human
TgeneRETC0027662Multiple Endocrine Neoplasia2CTD_human;GENOMICS_ENGLAND
TgeneRETC0085758Aganglionosis, Colonic2CTD_human
TgeneRETC0266294Unilateral agenesis of kidney2ORPHANET
TgeneRETC1257840Aganglionosis, Rectosigmoid Colon2CTD_human
TgeneRETC3661523Congenital Intestinal Aganglionosis2CTD_human
TgeneRETC0006413Burkitt Lymphoma1CTD_human
TgeneRETC0031511Pheochromocytoma1CGI;CTD_human;GENOMICS_ENGLAND;UNIPROT
TgeneRETC0038220Status Epilepticus1CTD_human
TgeneRETC0040136Thyroid Neoplasm1CGI;CTD_human
TgeneRETC0151468Thyroid Gland Follicular Adenoma1CTD_human
TgeneRETC0206693Medullary carcinoma1CTD_human
TgeneRETC0238462Medullary carcinoma of thyroid1CGI;CTD_human
TgeneRETC0270823Petit mal status1CTD_human
TgeneRETC0311335Grand Mal Status Epilepticus1CTD_human
TgeneRETC0343640African Burkitt's lymphoma1CTD_human
TgeneRETC0393734Complex Partial Status Epilepticus1CTD_human
TgeneRETC0549473Thyroid carcinoma1CGI;CTD_human;UNIPROT
TgeneRETC0740340Amyloidosis, Familial1CTD_human
TgeneRETC0751522Status Epilepticus, Subclinical1CTD_human
TgeneRETC0751523Non-Convulsive Status Epilepticus1CTD_human
TgeneRETC0751524Simple Partial Status Epilepticus1CTD_human
TgeneRETC1257877Pheochromocytoma, Extra-Adrenal1CTD_human
TgeneRETC1609433Congenital absence of kidneys syndrome1CTD_human;GENOMICS_ENGLAND;ORPHANET
TgeneRETC3501843Nonmedullary Thyroid Carcinoma1CTD_human
TgeneRETC3501844Familial Nonmedullary Thyroid Cancer1CTD_human
TgeneRETC4721444Burkitt Leukemia1CTD_human