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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:RAB3D-DMBT1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: RAB3D-DMBT1
FusionPDB ID: 71342
FusionGDB2.0 ID: 71342
HgeneTgene
Gene symbol

RAB3D

DMBT1

Gene ID

9545

1755

Gene nameRAB3D, member RAS oncogene familydeleted in malignant brain tumors 1
SynonymsD2-2|GOV|RAB16|RAD3DGP340|SAG|SALSA|muclin
Cytomap

19p13.2

10q26.13

Type of geneprotein-codingprotein-coding
Descriptionras-related protein Rab-3DRab3D upregulated with myeloid differentiationepididymis secretory sperm binding proteinglioblastoma overexpresseddeleted in malignant brain tumors 1 proteinglycoprotein 340hensinsalivary agglutininsalivary scavenger and agglutininsurfactant pulmonary-associated D-binding proteinvomeroglandin
Modification date2020031320200313
UniProtAcc.

Q9UGM3

Ensembl transtripts involved in fusion geneENST idsENST00000589655, ENST00000222120, 
ENST00000330163, ENST00000338354, 
ENST00000344338, ENST00000359586, 
ENST00000368909, ENST00000368955, 
ENST00000368956, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score9 X 8 X 7=5042 X 2 X 2=8
# samples 102
** MAII scorelog2(10/504*10)=-2.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/8*10)=1.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: RAB3D [Title/Abstract] AND DMBT1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)RAB3D(11447848)-DMBT1(124395507), # samples:2
Anticipated loss of major functional domain due to fusion event.RAB3D-DMBT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RAB3D-DMBT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
RAB3D-DMBT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RAB3D-DMBT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
RAB3D-DMBT1 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneRAB3D

GO:0045453

bone resorption

21262767


check buttonFusion gene breakpoints across RAB3D (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DMBT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-7254-01ARAB3Dchr19

11447848

-DMBT1chr10

124395507

+
ChimerDB4HNSCTCGA-CV-7254RAB3Dchr19

11447848

-DMBT1chr10

124395507

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000222120RAB3Dchr1911447848-ENST00000344338DMBT1chr10124395507+19084894211569382
ENST00000222120RAB3Dchr1911447848-ENST00000368955DMBT1chr10124395507+19084894211569382
ENST00000222120RAB3Dchr1911447848-ENST00000330163DMBT1chr10124395507+19084894211569382
ENST00000222120RAB3Dchr1911447848-ENST00000338354DMBT1chr10124395507+19084894211569382
ENST00000222120RAB3Dchr1911447848-ENST00000368956DMBT1chr10124395507+19084894211569382
ENST00000222120RAB3Dchr1911447848-ENST00000368909DMBT1chr10124395507+19084894211569382
ENST00000222120RAB3Dchr1911447848-ENST00000359586DMBT1chr10124395507+19084894211569382

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000222120ENST00000344338RAB3Dchr1911447848-DMBT1chr10124395507+0.0047813880.9952186
ENST00000222120ENST00000368955RAB3Dchr1911447848-DMBT1chr10124395507+0.0047813880.9952186
ENST00000222120ENST00000330163RAB3Dchr1911447848-DMBT1chr10124395507+0.0047813880.9952186
ENST00000222120ENST00000338354RAB3Dchr1911447848-DMBT1chr10124395507+0.0047813880.9952186
ENST00000222120ENST00000368956RAB3Dchr1911447848-DMBT1chr10124395507+0.0047813880.9952186
ENST00000222120ENST00000368909RAB3Dchr1911447848-DMBT1chr10124395507+0.0047813880.9952186
ENST00000222120ENST00000359586RAB3Dchr1911447848-DMBT1chr10124395507+0.0047813880.9952186

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>71342_71342_1_RAB3D-DMBT1_RAB3D_chr19_11447848_ENST00000222120_DMBT1_chr10_124395507_ENST00000330163_length(amino acids)=382AA_BP=23
MWASISRSRPSTAMTRGSSCRSGLEGGCNYDYIEVFDGPYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEYYSSPSND
STNLLCLPNHMQASVSRSYLQSLGFSASDLVISTWNGYYECRPQITPNLVIFTIPYSGCGTFKQADNDTIDYSNFLTAAVSGGIIKRRTD
LRIHVSCRMLQNTWVDTMYIANDTIHVANNTIQVEEVQYGNFDVNISFYTSSSFLYPVTSRPYYVDLNQDLYVQAEILHSDAVLTLFVDT
CVASPYSNDFTSLTYDLIRSGCVRDDTYGPYSSPSLRIARFRFRAFHFLNRFPSVYLRCKMVVCRAYDPSSRCYRGCVLRSKRDVGSYQE

--------------------------------------------------------------

>71342_71342_2_RAB3D-DMBT1_RAB3D_chr19_11447848_ENST00000222120_DMBT1_chr10_124395507_ENST00000338354_length(amino acids)=382AA_BP=23
MWASISRSRPSTAMTRGSSCRSGLEGGCNYDYIEVFDGPYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEYYSSPSND
STNLLCLPNHMQASVSRSYLQSLGFSASDLVISTWNGYYECRPQITPNLVIFTIPYSGCGTFKQADNDTIDYSNFLTAAVSGGIIKRRTD
LRIHVSCRMLQNTWVDTMYIANDTIHVANNTIQVEEVQYGNFDVNISFYTSSSFLYPVTSRPYYVDLNQDLYVQAEILHSDAVLTLFVDT
CVASPYSNDFTSLTYDLIRSGCVRDDTYGPYSSPSLRIARFRFRAFHFLNRFPSVYLRCKMVVCRAYDPSSRCYRGCVLRSKRDVGSYQE

--------------------------------------------------------------

>71342_71342_3_RAB3D-DMBT1_RAB3D_chr19_11447848_ENST00000222120_DMBT1_chr10_124395507_ENST00000344338_length(amino acids)=382AA_BP=23
MWASISRSRPSTAMTRGSSCRSGLEGGCNYDYIEVFDGPYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEYYSSPSND
STNLLCLPNHMQASVSRSYLQSLGFSASDLVISTWNGYYECRPQITPNLVIFTIPYSGCGTFKQADNDTIDYSNFLTAAVSGGIIKRRTD
LRIHVSCRMLQNTWVDTMYIANDTIHVANNTIQVEEVQYGNFDVNISFYTSSSFLYPVTSRPYYVDLNQDLYVQAEILHSDAVLTLFVDT
CVASPYSNDFTSLTYDLIRSGCVRDDTYGPYSSPSLRIARFRFRAFHFLNRFPSVYLRCKMVVCRAYDPSSRCYRGCVLRSKRDVGSYQE

--------------------------------------------------------------

>71342_71342_4_RAB3D-DMBT1_RAB3D_chr19_11447848_ENST00000222120_DMBT1_chr10_124395507_ENST00000359586_length(amino acids)=382AA_BP=23
MWASISRSRPSTAMTRGSSCRSGLEGGCNYDYIEVFDGPYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEYYSSPSND
STNLLCLPNHMQASVSRSYLQSLGFSASDLVISTWNGYYECRPQITPNLVIFTIPYSGCGTFKQADNDTIDYSNFLTAAVSGGIIKRRTD
LRIHVSCRMLQNTWVDTMYIANDTIHVANNTIQVEEVQYGNFDVNISFYTSSSFLYPVTSRPYYVDLNQDLYVQAEILHSDAVLTLFVDT
CVASPYSNDFTSLTYDLIRSGCVRDDTYGPYSSPSLRIARFRFRAFHFLNRFPSVYLRCKMVVCRAYDPSSRCYRGCVLRSKRDVGSYQE

--------------------------------------------------------------

>71342_71342_5_RAB3D-DMBT1_RAB3D_chr19_11447848_ENST00000222120_DMBT1_chr10_124395507_ENST00000368909_length(amino acids)=382AA_BP=23
MWASISRSRPSTAMTRGSSCRSGLEGGCNYDYIEVFDGPYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEYYSSPSND
STNLLCLPNHMQASVSRSYLQSLGFSASDLVISTWNGYYECRPQITPNLVIFTIPYSGCGTFKQADNDTIDYSNFLTAAVSGGIIKRRTD
LRIHVSCRMLQNTWVDTMYIANDTIHVANNTIQVEEVQYGNFDVNISFYTSSSFLYPVTSRPYYVDLNQDLYVQAEILHSDAVLTLFVDT
CVASPYSNDFTSLTYDLIRSGCVRDDTYGPYSSPSLRIARFRFRAFHFLNRFPSVYLRCKMVVCRAYDPSSRCYRGCVLRSKRDVGSYQE

--------------------------------------------------------------

>71342_71342_6_RAB3D-DMBT1_RAB3D_chr19_11447848_ENST00000222120_DMBT1_chr10_124395507_ENST00000368955_length(amino acids)=382AA_BP=23
MWASISRSRPSTAMTRGSSCRSGLEGGCNYDYIEVFDGPYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEYYSSPSND
STNLLCLPNHMQASVSRSYLQSLGFSASDLVISTWNGYYECRPQITPNLVIFTIPYSGCGTFKQADNDTIDYSNFLTAAVSGGIIKRRTD
LRIHVSCRMLQNTWVDTMYIANDTIHVANNTIQVEEVQYGNFDVNISFYTSSSFLYPVTSRPYYVDLNQDLYVQAEILHSDAVLTLFVDT
CVASPYSNDFTSLTYDLIRSGCVRDDTYGPYSSPSLRIARFRFRAFHFLNRFPSVYLRCKMVVCRAYDPSSRCYRGCVLRSKRDVGSYQE

--------------------------------------------------------------

>71342_71342_7_RAB3D-DMBT1_RAB3D_chr19_11447848_ENST00000222120_DMBT1_chr10_124395507_ENST00000368956_length(amino acids)=382AA_BP=23
MWASISRSRPSTAMTRGSSCRSGLEGGCNYDYIEVFDGPYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEYYSSPSND
STNLLCLPNHMQASVSRSYLQSLGFSASDLVISTWNGYYECRPQITPNLVIFTIPYSGCGTFKQADNDTIDYSNFLTAAVSGGIIKRRTD
LRIHVSCRMLQNTWVDTMYIANDTIHVANNTIQVEEVQYGNFDVNISFYTSSSFLYPVTSRPYYVDLNQDLYVQAEILHSDAVLTLFVDT
CVASPYSNDFTSLTYDLIRSGCVRDDTYGPYSSPSLRIARFRFRAFHFLNRFPSVYLRCKMVVCRAYDPSSRCYRGCVLRSKRDVGSYQE

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:11447848/chr10:124395507)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.DMBT1

Q9UGM3

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: May be considered as a candidate tumor suppressor gene for brain, lung, esophageal, gastric, and colorectal cancers. May play roles in mucosal defense system, cellular immune defense and epithelial differentiation. May play a role as an opsonin receptor for SFTPD and SPAR in macrophage tissues throughout the body, including epithelial cells lining the gastrointestinal tract. May play a role in liver regeneration. May be an important factor in fate decision and differentiation of transit-amplifying ductular (oval) cells within the hepatic lineage. Required for terminal differentiation of columnar epithelial cells during early embryogenesis. May function as a binding protein in saliva for the regulation of taste sensation. Binds to HIV-1 envelope protein and has been shown to both inhibit and facilitate viral transmission. Displays a broad calcium-dependent binding spectrum against both Gram-positive and Gram-negative bacteria, suggesting a role in defense against bacterial pathogens. Binds to a range of poly-sulfated and poly-phosphorylated ligands which may explain its broad bacterial-binding specificity. Inhibits cytoinvasion of S.enterica. Associates with the actin cytoskeleton and is involved in its remodeling during regulated exocytosis. Interacts with pancreatic zymogens in a pH-dependent manner and may act as a Golgi cargo receptor in the regulated secretory pathway of the pancreatic acinar cell. {ECO:0000269|PubMed:10485905, ECO:0000269|PubMed:11007786, ECO:0000269|PubMed:11751412, ECO:0000269|PubMed:16796526, ECO:0000269|PubMed:17548659, ECO:0000269|PubMed:17709527, ECO:0000269|PubMed:19189310, ECO:0000269|PubMed:9288095}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAB3Dchr19:11447848chr10:124395507ENST00000222120-2551_5976.0220.0MotifEffector region
HgeneRAB3Dchr19:11447848chr10:124395507ENST00000589655-2551_5976.0220.0MotifEffector region
HgeneRAB3Dchr19:11447848chr10:124395507ENST00000222120-2529_3776.0220.0Nucleotide bindingGTP
HgeneRAB3Dchr19:11447848chr10:124395507ENST00000222120-2548_5476.0220.0Nucleotide bindingGTP
HgeneRAB3Dchr19:11447848chr10:124395507ENST00000589655-2529_3776.0220.0Nucleotide bindingGTP
HgeneRAB3Dchr19:11447848chr10:124395507ENST00000589655-2548_5476.0220.0Nucleotide bindingGTP
TgeneDMBT1chr19:11447848chr10:124395507ENST0000033016335401755_17591425.66666666666671786.0Compositional biasNote=Poly-Thr
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036895635401755_17591425.66666666666671786.0Compositional biasNote=Poly-Thr
TgeneDMBT1chr19:11447848chr10:124395507ENST0000033016335401509_16091425.66666666666671786.0DomainSRCR 12
TgeneDMBT1chr19:11447848chr10:124395507ENST0000033016335401640_17401425.66666666666671786.0DomainSRCR 13
TgeneDMBT1chr19:11447848chr10:124395507ENST0000033016335401766_18771425.66666666666671786.0DomainCUB 1
TgeneDMBT1chr19:11447848chr10:124395507ENST0000033016335401883_19861425.66666666666671786.0DomainSRCR 14
TgeneDMBT1chr19:11447848chr10:124395507ENST0000033016335402008_21171425.66666666666671786.0DomainCUB 2
TgeneDMBT1chr19:11447848chr10:124395507ENST0000033016335402126_23811425.66666666666671786.0DomainZP
TgeneDMBT1chr19:11447848chr10:124395507ENST0000033835448532126_23812053.66666666666652414.0DomainZP
TgeneDMBT1chr19:11447848chr10:124395507ENST0000034433847522126_23812043.66666666666672404.0DomainZP
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036890948532126_23812053.66666666666652414.0DomainZP
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036895547522126_23812043.66666666666672404.0DomainZP
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036895635401509_16091425.66666666666671786.0DomainSRCR 12
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036895635401640_17401425.66666666666671786.0DomainSRCR 13
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036895635401766_18771425.66666666666671786.0DomainCUB 1
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036895635401883_19861425.66666666666671786.0DomainSRCR 14
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036895635402008_21171425.66666666666671786.0DomainCUB 2
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036895635402126_23811425.66666666666671786.0DomainZP

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneRAB3Dchr19:11447848chr10:124395507ENST00000222120-25135_13876.0220.0Nucleotide bindingGTP
HgeneRAB3Dchr19:11447848chr10:124395507ENST00000222120-25165_16776.0220.0Nucleotide bindingGTP
HgeneRAB3Dchr19:11447848chr10:124395507ENST00000222120-2577_8176.0220.0Nucleotide bindingGTP
HgeneRAB3Dchr19:11447848chr10:124395507ENST00000589655-25135_13876.0220.0Nucleotide bindingGTP
HgeneRAB3Dchr19:11447848chr10:124395507ENST00000589655-25165_16776.0220.0Nucleotide bindingGTP
HgeneRAB3Dchr19:11447848chr10:124395507ENST00000589655-2577_8176.0220.0Nucleotide bindingGTP
TgeneDMBT1chr19:11447848chr10:124395507ENST0000033835448531755_17592053.66666666666652414.0Compositional biasNote=Poly-Thr
TgeneDMBT1chr19:11447848chr10:124395507ENST0000034433847521755_17592043.66666666666672404.0Compositional biasNote=Poly-Thr
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036890948531755_17592053.66666666666652414.0Compositional biasNote=Poly-Thr
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036895547521755_17592043.66666666666672404.0Compositional biasNote=Poly-Thr
TgeneDMBT1chr19:11447848chr10:124395507ENST000003301633540102_2021425.66666666666671786.0DomainSRCR 1
TgeneDMBT1chr19:11447848chr10:124395507ENST0000033016335401122_12221425.66666666666671786.0DomainSRCR 9
TgeneDMBT1chr19:11447848chr10:124395507ENST0000033016335401251_13511425.66666666666671786.0DomainSRCR 10
TgeneDMBT1chr19:11447848chr10:124395507ENST0000033016335401380_14801425.66666666666671786.0DomainSRCR 11
TgeneDMBT1chr19:11447848chr10:124395507ENST000003301633540234_3341425.66666666666671786.0DomainSRCR 2
TgeneDMBT1chr19:11447848chr10:124395507ENST000003301633540363_4631425.66666666666671786.0DomainSRCR 3
TgeneDMBT1chr19:11447848chr10:124395507ENST000003301633540494_5941425.66666666666671786.0DomainSRCR 4
TgeneDMBT1chr19:11447848chr10:124395507ENST000003301633540602_7021425.66666666666671786.0DomainSRCR 5
TgeneDMBT1chr19:11447848chr10:124395507ENST000003301633540733_8331425.66666666666671786.0DomainSRCR 6
TgeneDMBT1chr19:11447848chr10:124395507ENST000003301633540862_9621425.66666666666671786.0DomainSRCR 7
TgeneDMBT1chr19:11447848chr10:124395507ENST000003301633540993_10931425.66666666666671786.0DomainSRCR 8
TgeneDMBT1chr19:11447848chr10:124395507ENST000003383544853102_2022053.66666666666652414.0DomainSRCR 1
TgeneDMBT1chr19:11447848chr10:124395507ENST0000033835448531122_12222053.66666666666652414.0DomainSRCR 9
TgeneDMBT1chr19:11447848chr10:124395507ENST0000033835448531251_13512053.66666666666652414.0DomainSRCR 10
TgeneDMBT1chr19:11447848chr10:124395507ENST0000033835448531380_14802053.66666666666652414.0DomainSRCR 11
TgeneDMBT1chr19:11447848chr10:124395507ENST0000033835448531509_16092053.66666666666652414.0DomainSRCR 12
TgeneDMBT1chr19:11447848chr10:124395507ENST0000033835448531640_17402053.66666666666652414.0DomainSRCR 13
TgeneDMBT1chr19:11447848chr10:124395507ENST0000033835448531766_18772053.66666666666652414.0DomainCUB 1
TgeneDMBT1chr19:11447848chr10:124395507ENST0000033835448531883_19862053.66666666666652414.0DomainSRCR 14
TgeneDMBT1chr19:11447848chr10:124395507ENST0000033835448532008_21172053.66666666666652414.0DomainCUB 2
TgeneDMBT1chr19:11447848chr10:124395507ENST000003383544853234_3342053.66666666666652414.0DomainSRCR 2
TgeneDMBT1chr19:11447848chr10:124395507ENST000003383544853363_4632053.66666666666652414.0DomainSRCR 3
TgeneDMBT1chr19:11447848chr10:124395507ENST000003383544853494_5942053.66666666666652414.0DomainSRCR 4
TgeneDMBT1chr19:11447848chr10:124395507ENST000003383544853602_7022053.66666666666652414.0DomainSRCR 5
TgeneDMBT1chr19:11447848chr10:124395507ENST000003383544853733_8332053.66666666666652414.0DomainSRCR 6
TgeneDMBT1chr19:11447848chr10:124395507ENST000003383544853862_9622053.66666666666652414.0DomainSRCR 7
TgeneDMBT1chr19:11447848chr10:124395507ENST000003383544853993_10932053.66666666666652414.0DomainSRCR 8
TgeneDMBT1chr19:11447848chr10:124395507ENST000003443384752102_2022043.66666666666672404.0DomainSRCR 1
TgeneDMBT1chr19:11447848chr10:124395507ENST0000034433847521122_12222043.66666666666672404.0DomainSRCR 9
TgeneDMBT1chr19:11447848chr10:124395507ENST0000034433847521251_13512043.66666666666672404.0DomainSRCR 10
TgeneDMBT1chr19:11447848chr10:124395507ENST0000034433847521380_14802043.66666666666672404.0DomainSRCR 11
TgeneDMBT1chr19:11447848chr10:124395507ENST0000034433847521509_16092043.66666666666672404.0DomainSRCR 12
TgeneDMBT1chr19:11447848chr10:124395507ENST0000034433847521640_17402043.66666666666672404.0DomainSRCR 13
TgeneDMBT1chr19:11447848chr10:124395507ENST0000034433847521766_18772043.66666666666672404.0DomainCUB 1
TgeneDMBT1chr19:11447848chr10:124395507ENST0000034433847521883_19862043.66666666666672404.0DomainSRCR 14
TgeneDMBT1chr19:11447848chr10:124395507ENST0000034433847522008_21172043.66666666666672404.0DomainCUB 2
TgeneDMBT1chr19:11447848chr10:124395507ENST000003443384752234_3342043.66666666666672404.0DomainSRCR 2
TgeneDMBT1chr19:11447848chr10:124395507ENST000003443384752363_4632043.66666666666672404.0DomainSRCR 3
TgeneDMBT1chr19:11447848chr10:124395507ENST000003443384752494_5942043.66666666666672404.0DomainSRCR 4
TgeneDMBT1chr19:11447848chr10:124395507ENST000003443384752602_7022043.66666666666672404.0DomainSRCR 5
TgeneDMBT1chr19:11447848chr10:124395507ENST000003443384752733_8332043.66666666666672404.0DomainSRCR 6
TgeneDMBT1chr19:11447848chr10:124395507ENST000003443384752862_9622043.66666666666672404.0DomainSRCR 7
TgeneDMBT1chr19:11447848chr10:124395507ENST000003443384752993_10932043.66666666666672404.0DomainSRCR 8
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689094853102_2022053.66666666666652414.0DomainSRCR 1
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036890948531122_12222053.66666666666652414.0DomainSRCR 9
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036890948531251_13512053.66666666666652414.0DomainSRCR 10
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036890948531380_14802053.66666666666652414.0DomainSRCR 11
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036890948531509_16092053.66666666666652414.0DomainSRCR 12
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036890948531640_17402053.66666666666652414.0DomainSRCR 13
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036890948531766_18772053.66666666666652414.0DomainCUB 1
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036890948531883_19862053.66666666666652414.0DomainSRCR 14
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036890948532008_21172053.66666666666652414.0DomainCUB 2
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689094853234_3342053.66666666666652414.0DomainSRCR 2
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689094853363_4632053.66666666666652414.0DomainSRCR 3
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689094853494_5942053.66666666666652414.0DomainSRCR 4
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689094853602_7022053.66666666666652414.0DomainSRCR 5
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689094853733_8332053.66666666666652414.0DomainSRCR 6
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689094853862_9622053.66666666666652414.0DomainSRCR 7
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689094853993_10932053.66666666666652414.0DomainSRCR 8
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689554752102_2022043.66666666666672404.0DomainSRCR 1
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036895547521122_12222043.66666666666672404.0DomainSRCR 9
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036895547521251_13512043.66666666666672404.0DomainSRCR 10
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036895547521380_14802043.66666666666672404.0DomainSRCR 11
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036895547521509_16092043.66666666666672404.0DomainSRCR 12
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036895547521640_17402043.66666666666672404.0DomainSRCR 13
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036895547521766_18772043.66666666666672404.0DomainCUB 1
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036895547521883_19862043.66666666666672404.0DomainSRCR 14
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036895547522008_21172043.66666666666672404.0DomainCUB 2
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689554752234_3342043.66666666666672404.0DomainSRCR 2
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689554752363_4632043.66666666666672404.0DomainSRCR 3
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689554752494_5942043.66666666666672404.0DomainSRCR 4
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689554752602_7022043.66666666666672404.0DomainSRCR 5
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689554752733_8332043.66666666666672404.0DomainSRCR 6
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689554752862_9622043.66666666666672404.0DomainSRCR 7
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689554752993_10932043.66666666666672404.0DomainSRCR 8
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689563540102_2021425.66666666666671786.0DomainSRCR 1
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036895635401122_12221425.66666666666671786.0DomainSRCR 9
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036895635401251_13511425.66666666666671786.0DomainSRCR 10
TgeneDMBT1chr19:11447848chr10:124395507ENST0000036895635401380_14801425.66666666666671786.0DomainSRCR 11
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689563540234_3341425.66666666666671786.0DomainSRCR 2
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689563540363_4631425.66666666666671786.0DomainSRCR 3
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689563540494_5941425.66666666666671786.0DomainSRCR 4
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689563540602_7021425.66666666666671786.0DomainSRCR 5
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689563540733_8331425.66666666666671786.0DomainSRCR 6
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689563540862_9621425.66666666666671786.0DomainSRCR 7
TgeneDMBT1chr19:11447848chr10:124395507ENST000003689563540993_10931425.66666666666671786.0DomainSRCR 8


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>764_RAB3D_11447848_DMBT1_124395507_ranked_0.pdbRAB3D1144784811447848ENST00000359586DMBT1chr10124395507+
MWASISRSRPSTAMTRGSSCRSGLEGGCNYDYIEVFDGPYRSSPLIARVCDGARGSFTSSSNFMSIRFISDHSITRRGFRAEYYSSPSND
STNLLCLPNHMQASVSRSYLQSLGFSASDLVISTWNGYYECRPQITPNLVIFTIPYSGCGTFKQADNDTIDYSNFLTAAVSGGIIKRRTD
LRIHVSCRMLQNTWVDTMYIANDTIHVANNTIQVEEVQYGNFDVNISFYTSSSFLYPVTSRPYYVDLNQDLYVQAEILHSDAVLTLFVDT
CVASPYSNDFTSLTYDLIRSGCVRDDTYGPYSSPSLRIARFRFRAFHFLNRFPSVYLRCKMVVCRAYDPSSRCYRGCVLRSKRDVGSYQE
382


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
RAB3D_pLDDT.png
all structure
all structure
DMBT1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
RAB3D
DMBT1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to RAB3D-DMBT1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to RAB3D-DMBT1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource