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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:RAB7A-TRMT1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: RAB7A-TRMT1
	FusionPDB ID: 71492
	FusionGDB2.0 ID: 71492
		Hgene	Tgene
	Gene symbol	RAB7A	TRMT1
	Gene ID	7879	55687
	Gene name	RAB7A, member RAS oncogene family	tRNA 5-methylaminomethyl-2-thiouridylate methyltransferase
	Synonyms	CMT2B\|PRO2706\|RAB7	LCAL3\|MTO2\|MTU1\|TRMT\|TRMT1
	Cytomap	3q21.3	22q13.31
	Type of gene	protein-coding	protein-coding
	Description	ras-related protein Rab-7aRAB7, member RAS oncogene familyRas-associated protein RAB7	mitochondrial tRNA-specific 2-thiouridylase 1MTO2 homologlung cancer associated lncRNA 3mitochondrial 5-methylaminomethyl-2-thiouridylate-methyltransferase
	Modification date	20200328	20200313
	UniProtAcc	.	TRMT1L
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000265062, ENST00000482525, ENST00000485280,	ENST00000592892, ENST00000221504, ENST00000357720, ENST00000437766, ENST00000592062,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	21 X 11 X 12=2772	4 X 5 X 4=80
	# samples	23	5
	** MAII score	log2(23/2772*10)=-3.59122149119284 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(5/80*10)=-0.678071905112638 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: RAB7A [Title/Abstract] AND TRMT1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	RAB7A(128526514)-TRMT1(13221120), # samples:2
Anticipated loss of major functional domain due to fusion event.	RAB7A-TRMT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RAB7A-TRMT1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RAB7A-TRMT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RAB7A-TRMT1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	RAB7A	GO:0022615	protein to membrane docking	24344282

Fusion gene breakpoints across RAB7A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TRMT1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	UCS	TCGA-N8-A4PP-01A	RAB7A	chr3	128526514	+	TRMT1	chr19	13221120	-
ChimerDB4	UCS	TCGA-N8-A4PP	RAB7A	chr3	128526514	+	TRMT1	chr19	13221120	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000265062	RAB7A	chr3	128526514	+	ENST00000437766	TRMT1	chr19	13221120	-	1917	774	246	1883	545
ENST00000265062	RAB7A	chr3	128526514	+	ENST00000357720	TRMT1	chr19	13221120	-	1917	774	246	1883	545
ENST00000265062	RAB7A	chr3	128526514	+	ENST00000221504	TRMT1	chr19	13221120	-	1825	774	246	1796	516
ENST00000265062	RAB7A	chr3	128526514	+	ENST00000592062	TRMT1	chr19	13221120	-	1912	774	246	1883	545
ENST00000482525	RAB7A	chr3	128526514	+	ENST00000437766	TRMT1	chr19	13221120	-	1705	562	175	1671	498
ENST00000482525	RAB7A	chr3	128526514	+	ENST00000357720	TRMT1	chr19	13221120	-	1705	562	175	1671	498
ENST00000482525	RAB7A	chr3	128526514	+	ENST00000221504	TRMT1	chr19	13221120	-	1613	562	175	1584	469
ENST00000482525	RAB7A	chr3	128526514	+	ENST00000592062	TRMT1	chr19	13221120	-	1700	562	175	1671	498

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000265062	ENST00000437766	RAB7A	chr3	128526514	+	TRMT1	chr19	13221120	-	0.014202925	0.9857971
ENST00000265062	ENST00000357720	RAB7A	chr3	128526514	+	TRMT1	chr19	13221120	-	0.014202925	0.9857971
ENST00000265062	ENST00000221504	RAB7A	chr3	128526514	+	TRMT1	chr19	13221120	-	0.011120067	0.9888799
ENST00000265062	ENST00000592062	RAB7A	chr3	128526514	+	TRMT1	chr19	13221120	-	0.014394164	0.9856059
ENST00000482525	ENST00000437766	RAB7A	chr3	128526514	+	TRMT1	chr19	13221120	-	0.030890549	0.9691095
ENST00000482525	ENST00000357720	RAB7A	chr3	128526514	+	TRMT1	chr19	13221120	-	0.030890549	0.9691095
ENST00000482525	ENST00000221504	RAB7A	chr3	128526514	+	TRMT1	chr19	13221120	-	0.031160336	0.96883965
ENST00000482525	ENST00000592062	RAB7A	chr3	128526514	+	TRMT1	chr19	13221120	-	0.031363606	0.9686364

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>71492_71492_1_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000265062_TRMT1_chr19_13221120_ENST00000221504_length(amino acids)=516AA_BP=175
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDV
TAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQALRI
VLHSLDLRANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKASARAKFSAACGPPVTPECEHCGQRHQLGGPMWAEPIHDLDFVGRVLE
AVSANPGRFHTSERIRGVLSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADFRVSLSHACKNAVKTDAPASALWDIMRCWE
KECPVKRERLSETSPAFRILSVEPRLQANFTIREDANPSSRQRGLKRFQANPEANWGPRPRARPGGKAADEAMEERRRLLQNKRKEPPED

--------------------------------------------------------------

>71492_71492_2_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000265062_TRMT1_chr19_13221120_ENST00000357720_length(amino acids)=545AA_BP=175
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDV
TAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQALRI
VLHSLDLRANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKASASKQALVFQCVGCGAFHLQRLGKASGVPSGRAKFSAACGPPVTPEC
EHCGQRHQLGGPMWAEPIHDLDFVGRVLEAVSANPGRFHTSERIRGVLSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADF
RVSLSHACKNAVKTDAPASALWDIMRCWEKECPVKRERLSETSPAFRILSVEPRLQANFTIREDANPSSRQRGLKRFQANPEANWGPRPR
ARPGGKAADEAMEERRRLLQNKRKEPPEDVAQRAARLKTFPCKRFKEGTCQRGDQCCYSHSPPTPRVSADAAPDCPETSNQTPPGPGAAA

--------------------------------------------------------------

>71492_71492_3_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000265062_TRMT1_chr19_13221120_ENST00000437766_length(amino acids)=545AA_BP=175
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDV
TAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQALRI
VLHSLDLRANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKASASKQALVFQCVGCGAFHLQRLGKASGVPSGRAKFSAACGPPVTPEC
EHCGQRHQLGGPMWAEPIHDLDFVGRVLEAVSANPGRFHTSERIRGVLSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADF
RVSLSHACKNAVKTDAPASALWDIMRCWEKECPVKRERLSETSPAFRILSVEPRLQANFTIREDANPSSRQRGLKRFQANPEANWGPRPR
ARPGGKAADEAMEERRRLLQNKRKEPPEDVAQRAARLKTFPCKRFKEGTCQRGDQCCYSHSPPTPRVSADAAPDCPETSNQTPPGPGAAA

--------------------------------------------------------------

>71492_71492_4_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000265062_TRMT1_chr19_13221120_ENST00000592062_length(amino acids)=545AA_BP=175
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDV
TAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQALRI
VLHSLDLRANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKASASKQALVFQCVGCGAFHLQRLGKASGVPSGRAKFSAACGPPVTPEC
EHCGQRHQLGGPMWAEPIHDLDFVGRVLEAVSANPGRFHTSERIRGVLSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADF
RVSLSHACKNAVKTDAPASALWDIMRCWEKECPVKRERLSETSPAFRILSVEPRLQANFTIREDANPSSRQRGLKRFQANPEANWGPRPR
ARPGGKAADEAMEERRRLLQNKRKEPPEDVAQRAARLKTFPCKRFKEGTCQRGDQCCYSHSPPTPRVSADAAPDCPETSNQTPPGPGAAA

--------------------------------------------------------------

>71492_71492_5_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000482525_TRMT1_chr19_13221120_ENST00000221504_length(amino acids)=469AA_BP=128
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVATK
RAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQALRIVLHSLDLRANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKASARA
KFSAACGPPVTPECEHCGQRHQLGGPMWAEPIHDLDFVGRVLEAVSANPGRFHTSERIRGVLSVITEELPDVPLYYTLDQLSSTIHCNTP
SLLQLRSALLHADFRVSLSHACKNAVKTDAPASALWDIMRCWEKECPVKRERLSETSPAFRILSVEPRLQANFTIREDANPSSRQRGLKR
FQANPEANWGPRPRARPGGKAADEAMEERRRLLQNKRKEPPEDVAQRAARLKTFPCKRFKEGTCQRGDQCCYSHSPPTPRVSADAAPDCP

--------------------------------------------------------------

>71492_71492_6_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000482525_TRMT1_chr19_13221120_ENST00000357720_length(amino acids)=498AA_BP=128
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVATK
RAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQALRIVLHSLDLRANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKASASK
QALVFQCVGCGAFHLQRLGKASGVPSGRAKFSAACGPPVTPECEHCGQRHQLGGPMWAEPIHDLDFVGRVLEAVSANPGRFHTSERIRGV
LSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADFRVSLSHACKNAVKTDAPASALWDIMRCWEKECPVKRERLSETSPAFR
ILSVEPRLQANFTIREDANPSSRQRGLKRFQANPEANWGPRPRARPGGKAADEAMEERRRLLQNKRKEPPEDVAQRAARLKTFPCKRFKE

--------------------------------------------------------------

>71492_71492_7_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000482525_TRMT1_chr19_13221120_ENST00000437766_length(amino acids)=498AA_BP=128
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVATK
RAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQALRIVLHSLDLRANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKASASK
QALVFQCVGCGAFHLQRLGKASGVPSGRAKFSAACGPPVTPECEHCGQRHQLGGPMWAEPIHDLDFVGRVLEAVSANPGRFHTSERIRGV
LSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADFRVSLSHACKNAVKTDAPASALWDIMRCWEKECPVKRERLSETSPAFR
ILSVEPRLQANFTIREDANPSSRQRGLKRFQANPEANWGPRPRARPGGKAADEAMEERRRLLQNKRKEPPEDVAQRAARLKTFPCKRFKE

--------------------------------------------------------------

>71492_71492_8_RAB7A-TRMT1_RAB7A_chr3_128526514_ENST00000482525_TRMT1_chr19_13221120_ENST00000592062_length(amino acids)=498AA_BP=128
MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVATK
RAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQALRIVLHSLDLRANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKASASK
QALVFQCVGCGAFHLQRLGKASGVPSGRAKFSAACGPPVTPECEHCGQRHQLGGPMWAEPIHDLDFVGRVLEAVSANPGRFHTSERIRGV
LSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADFRVSLSHACKNAVKTDAPASALWDIMRCWEKECPVKRERLSETSPAFR
ILSVEPRLQANFTIREDANPSSRQRGLKRFQANPEANWGPRPRARPGGKAADEAMEERRRLLQNKRKEPPEDVAQRAARLKTFPCKRFKE

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:128526514/chr19:13221120)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	TRMT1 TRMT1L
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	733

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RAB7A

chr3:128526514

chr19:13221120

ENST00000265062

37_45

176.0

208.0

Motif

Effector region

Hgene

RAB7A

chr3:128526514

chr19:13221120

ENST00000265062

125_128

176.0

208.0

Nucleotide binding

GTP

Hgene

RAB7A

chr3:128526514

chr19:13221120

ENST00000265062

156_157

176.0

208.0

Nucleotide binding

GTP

Hgene

RAB7A

chr3:128526514

chr19:13221120

ENST00000265062

15_22

176.0

208.0

Nucleotide binding

GTP

Hgene

RAB7A

chr3:128526514

chr19:13221120

ENST00000265062

34_40

176.0

208.0

Nucleotide binding

GTP

Hgene

RAB7A

chr3:128526514

chr19:13221120

ENST00000265062

63_67

176.0

208.0

Nucleotide binding

GTP

Tgene

TRMT1

chr3:128526514

chr19:13221120

ENST00000221504

600_627

290.0

631.0

Zinc finger

C3H1-type

Tgene

TRMT1

chr3:128526514

chr19:13221120

ENST00000357720

600_627

290.0

660.0

Zinc finger

C3H1-type

Tgene

TRMT1

chr3:128526514

chr19:13221120

ENST00000437766

600_627

290.0

660.0

Zinc finger

C3H1-type

Tgene

TRMT1

chr3:128526514

chr19:13221120

ENST00000592062

600_627

290.0

660.0

Zinc finger

C3H1-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

TRMT1

chr3:128526514

chr19:13221120

ENST00000221504

55_499

290.0

631.0

Domain

Trm1 methyltransferase

Tgene

TRMT1

chr3:128526514

chr19:13221120

ENST00000357720

55_499

290.0

660.0

Domain

Trm1 methyltransferase

Tgene

TRMT1

chr3:128526514

chr19:13221120

ENST00000437766

55_499

290.0

660.0

Domain

Trm1 methyltransferase

Tgene

TRMT1

chr3:128526514

chr19:13221120

ENST00000592062

55_499

290.0

660.0

Domain

Trm1 methyltransferase

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1167_RAB7A_128526514_TRMT1_13221120_1167_RAB7A_128526514_TRMT1_13221120_ranked_0.pdb	RAB7A	128526514	128526514	ENST00000592062	TRMT1	chr19	13221120	-	MTSRKKVLLKVIILGDSGVGKTSLMNQYVNKKFSNQYKATIGADFLTKEVMVDDRLVTMQIWDTAGQERFQSLGVAFYRGADCCVLVFDV TAPNTFKTLDSWRDEFLIQASPRDPENFPFVVLGNKIDLENRQVATKRAQAWCYSKNNIPYFETSAKEAINVEQAFQTIARNALKQALRI VLHSLDLRANCYQRFVVPLLSISADFYVRVFVRVFTGQAKVKASASKQALVFQCVGCGAFHLQRLGKASGVPSGRAKFSAACGPPVTPEC EHCGQRHQLGGPMWAEPIHDLDFVGRVLEAVSANPGRFHTSERIRGVLSVITEELPDVPLYYTLDQLSSTIHCNTPSLLQLRSALLHADF RVSLSHACKNAVKTDAPASALWDIMRCWEKECPVKRERLSETSPAFRILSVEPRLQANFTIREDANPSSRQRGLKRFQANPEANWGPRPR ARPGGKAADEAMEERRRLLQNKRKEPPEDVAQRAARLKTFPCKRFKEGTCQRGDQCCYSHSPPTPRVSADAAPDCPETSNQTPPGPGAAA	545

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

RAB7A_pLDDT.png

TRMT1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
RAB7A
TRMT1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to RAB7A-TRMT1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to RAB7A-TRMT1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source