UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:RBM10-TFE3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: RBM10-TFE3
	FusionPDB ID: 72752
	FusionGDB2.0 ID: 72752
		Hgene	Tgene
	Gene symbol	RBM10	TFE3
	Gene ID	8241	7030
	Gene name	RNA binding motif protein 10	transcription factor binding to IGHM enhancer 3
	Synonyms	DXS8237E\|GPATC9\|GPATCH9\|S1-1\|TARPS\|ZRANB5	RCCP2\|RCCX1\|TFEA\|bHLHe33
	Cytomap	Xp11.3	Xp11.23
	Type of gene	protein-coding	protein-coding
	Description	RNA-binding protein 10RNA-binding protein S1-1epididymis secretory sperm binding proteing patch domain-containing protein 9	transcription factor E3class E basic helix-loop-helix protein 33transcription factor E family, member Atranscription factor for IgH enhancertranscription factor for immunoglobulin heavy-chain enhancer 3
	Modification date	20200313	20200327
	UniProtAcc	.	P19532
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000329236, ENST00000345781, ENST00000377604, ENST00000478410,	ENST00000487451, ENST00000315869,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	17 X 8 X 9=1224	14 X 15 X 6=1260
	# samples	18	15
	** MAII score	log2(18/1224*10)=-2.76553474636298 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(15/1260*10)=-3.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: RBM10 [Title/Abstract] AND TFE3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	RBM10(47041725)-TFE3(48895639), # samples:3
Anticipated loss of major functional domain due to fusion event.	RBM10-TFE3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RBM10-TFE3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RBM10-TFE3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RBM10-TFE3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across RBM10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across TFE3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	KIRP	TCGA-DZ-6131-01A	RBM10	chrX	47041725	-	TFE3	chrX	48895639	-
ChimerDB4	KIRP	TCGA-DZ-6131-01A	RBM10	chrX	47041725	+	TFE3	chrX	48895639	-
ChimerDB4	KIRP	TCGA-DZ-6131	RBM10	chrX	47041725	+	TFE3	chrX	48895639	-
ChimerKB4	.	.	RBM10	chrX	47041560	+	TFE3	chrX	47041560	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000377604	RBM10	chrX	47041725	+	ENST00000315869	TFE3	chrX	48895639	-	5067	2692	424	3639	1071
ENST00000329236	RBM10	chrX	47041725	+	ENST00000315869	TFE3	chrX	48895639	-	4470	2095	61	3042	993
ENST00000345781	RBM10	chrX	47041725	+	ENST00000315869	TFE3	chrX	48895639	-	4426	2051	14	2998	994

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000377604	ENST00000315869	RBM10	chrX	47041725	+	TFE3	chrX	48895639	-	0.004157387	0.99584264
ENST00000329236	ENST00000315869	RBM10	chrX	47041725	+	TFE3	chrX	48895639	-	0.006056023	0.993944
ENST00000345781	ENST00000315869	RBM10	chrX	47041725	+	TFE3	chrX	48895639	-	0.005462841	0.9945372

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>72752_72752_1_RBM10-TFE3_RBM10_chrX_47041725_ENST00000329236_TFE3_chrX_48895639_ENST00000315869_length(amino acids)=993AA_BP=661
MGVGGSEFPWEGSALGASPLPPICLQSRTWLLRAPAPAELGELEEVAAGRGDVWEPFLDSPGREESLQEASPRLADHGSSSGGGWEVKRS
QRLRRGPSSPRRPYQDMEYERRGGRGDRTGRYGATDRSQDDGGENRSRDHDYRDMDYRSYPREYGSQEGKHDYDDSSEEQSAEIRGQLQS
HGVQAREVRLMRNKSSGQSRGFAFVEFSHLQDATRWMEANQHSLNILGQKVSMHYSDPKPKINEDWLCNKCGVQNFKRREKCFKCGVPKS
EAEQKLPLGTRLDQQTLPLGGRELSQGLLPLPQPYQAQGVLASQALSQGSEPSSENANDTIILRNLNPHSTMDSILGALAPYAVLSSSNV
RVIKDKQTQLNRGFAFIQLSTIEAAQLLQILQALHPPLTIDGKTINVEFAKGSKRDMASNEGSRISAASVASTAIAAAQWAISQASQGGE
GTWATSEEPPVDYSYYQQDEGYGNSQGTESSLYAHGYLKGTKGPGITGTKGDPTGAGPEASLEPGADSVSMQAFSRAQPGAAPGIYQQSA
EASSSQGTAANSQSYTIMSPAVLKSELQSPTHPSSALPPATSPTAQESYSQYPVPDVSTYQYDETSGYYYDPQTGLYYDPNSQYYYNAQS
QQYLYWDGERRTYVPALEQSADGHKETGAPSKEGKEKKEKHKTKTAQQIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNL
LDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKAS
VDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVGGG
PAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGVVGGLSGGALSPLRAASDPLLSSVSPAVSKASSRRSSFSME

--------------------------------------------------------------

>72752_72752_2_RBM10-TFE3_RBM10_chrX_47041725_ENST00000345781_TFE3_chrX_48895639_ENST00000315869_length(amino acids)=994AA_BP=662
MGVGGSEFPWEGSALGASPLPPICLQSRTWLLRAPAPAELGELEEVAAGRGDVWEPFLDSPGREESLQEASPRLADHGSSSGGGWEVKRS
QRLRRGPSSPRRPYQDMEYERRGGRGDRTGRYGATDRSQDDGGENRSRDHDYRDMDYRSYPREYGSQEGKHDYDDSSEEQSAEIRGQLQS
HGVQAREVRLMRNKSSGQSRGFAFVEFSHLQDATRWMEANQHSLNILGQKVSMHYSDPKPKINEDWLCNKCGVQNFKRREKCFKCGVPKS
EAEQKLPLGTRLDQQTLPLGGRELSQGLLPLPQPYQAQGVLASQALSQGSEPSSENANDTIILRNLNPHSTMDSILGALAPYAVLSSSNV
RVIKDKQTQLNRGFAFIQLSTIVEAAQLLQILQALHPPLTIDGKTINVEFAKGSKRDMASNEGSRISAASVASTAIAAAQWAISQASQGG
EGTWATSEEPPVDYSYYQQDEGYGNSQGTESSLYAHGYLKGTKGPGITGTKGDPTGAGPEASLEPGADSVSMQAFSRAQPGAAPGIYQQS
AEASSSQGTAANSQSYTIMSPAVLKSELQSPTHPSSALPPATSPTAQESYSQYPVPDVSTYQYDETSGYYYDPQTGLYYDPNSQYYYNAQ
SQQYLYWDGERRTYVPALEQSADGHKETGAPSKEGKEKKEKHKTKTAQQIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGN
LLDVYSSQGVATPAITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKA
SVDYIRKLQKEQQRSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVGG
GPAQNAPHQQPPAPPSDALLDLHFPSDHLGDLGDPFHLGLEDILMEEEEGVVGGLSGGALSPLRAASDPLLSSVSPAVSKASSRRSSFSM

--------------------------------------------------------------

>72752_72752_3_RBM10-TFE3_RBM10_chrX_47041725_ENST00000377604_TFE3_chrX_48895639_ENST00000315869_length(amino acids)=1071AA_BP=215
MGVGGSEFPWEGSALGASPLPPICLQSRTWLLRAPAPAELGELEEVAAGRGDVWEPFLDSPGREESLQEASPRLADHGSSSGGGWEVKRS
QRLRRGPSSPRRPYQDMEYERRGGRGDRTGRYGATDRSQDDGGENRSRDHDYRDMDYRSYPREYGSQEGKHDYDDSSEEQSAEDSYEASP
GSETQRRRRRRHRHSPTGPPGFPRDGDYRDQDYRTEQGEEEEEEEDEEEEEKASNIVMLRMLPQAATEDDIRGQLQSHGVQAREVRLMRN
KSSGQSRGFAFVEFSHLQDATRWMEANQHSLNILGQKVSMHYSDPKPKINEDWLCNKCGVQNFKRREKCFKCGVPKSEAEQKLPLGTRLD
QQTLPLGGRELSQGLLPLPQPYQAQGVLASQALSQGSEPSSENANDTIILRNLNPHSTMDSILGALAPYAVLSSSNVRVIKDKQTQLNRG
FAFIQLSTIVEAAQLLQILQALHPPLTIDGKTINVEFAKGSKRDMASNEGSRISAASVASTAIAAAQWAISQASQGGEGTWATSEEPPVD
YSYYQQDEGYGNSQGTESSLYAHGYLKGTKGPGITGTKGDPTGAGPEASLEPGADSVSMQAFSRAQPGAAPGIYQQSAEASSSQGTAANS
QSYTIMSPAVLKSELQSPTHPSSALPPATSPTAQESYSQYPVPDVSTYQYDETSGYYYDPQTGLYYDPNSQYYYNAQSQQYLYWDGERRT
YVPALEQSADGHKETGAPSKEGKEKKEKHKTKTAQQIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATP
AITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQ
RSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVGGGPAQNAPHQQPPA

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:47041725/chrX:48895639)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	TFE3 P19532
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Transcription factor that acts as a master regulator of lysosomal biogenesis and immune response (PubMed:2338243, PubMed:29146937, PubMed:30733432, PubMed:31672913). Specifically recognizes and binds E-box sequences (5'-CANNTG-3'); efficient DNA-binding requires dimerization with itself or with another MiT/TFE family member such as TFEB or MITF (By similarity). Involved in the cellular response to amino acid availability by acting downstream of MTOR: in the presence of nutrients, TFE3 phosphorylation by MTOR promotes its cytosolic retention and subsequent inactivation (PubMed:31672913). Upon starvation or lysosomal stress, inhibition of MTOR induces TFE3 dephosphorylation, resulting in nuclear localization and transcription factor activity (PubMed:31672913). In association with TFEB, activates the expression of CD40L in T-cells, thereby playing a role in T-cell-dependent antibody responses in activated CD4(+) T-cells and thymus-dependent humoral immunity (By similarity). Specifically recognizes the MUE3 box, a subset of E-boxes, present in the immunoglobulin enhancer (PubMed:2338243). It also binds very well to a USF/MLTF site (PubMed:2338243). May regulate lysosomal positioning in response to nutrient deprivation by promoting the expression of PIP4P1 (PubMed:29146937). Acts as a positive regulator of browning of adipose tissue by promoting expression of target genes; mTOR-dependent phosphorylation promotes cytoplasmic retention of TFE3 and inhibits browning of adipose tissue (By similarity). Maintains the pluripotent state of embryonic stem cells by promoting the expression of genes such as ESRRB; mTOR-dependent nuclear exclusion promotes exit from pluripotency (By similarity). Required to maintain the naive pluripotent state of hematopoietic stem cell; mTOR-dependent cytoplasmic retention of TFE3 promotes the exit of hematopoietic stem cell from pluripotency (PubMed:30733432). {ECO:0000250\|UniProtKB:Q64092, ECO:0000269\|PubMed:2338243, ECO:0000269\|PubMed:29146937, ECO:0000269\|PubMed:30733432, ECO:0000269\|PubMed:31672913}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000329236

113_125

572.0

853.0

Compositional bias

Note=Poly-Glu

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000329236

80_87

572.0

853.0

Compositional bias

Note=Poly-Arg

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000345781

113_125

573.0

854.0

Compositional bias

Note=Poly-Glu

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000345781

80_87

573.0

854.0

Compositional bias

Note=Poly-Arg

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000377604

113_125

650.0

931.0

Compositional bias

Note=Poly-Glu

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000377604

561_607

650.0

931.0

Compositional bias

Note=Tyr-rich

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000377604

80_87

650.0

931.0

Compositional bias

Note=Poly-Arg

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000329236

129_209

572.0

853.0

Domain

RRM 1

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000329236

300_384

572.0

853.0

Domain

RRM 2

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000345781

129_209

573.0

854.0

Domain

RRM 1

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000345781

300_384

573.0

854.0

Domain

RRM 2

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000377604

129_209

650.0

931.0

Domain

RRM 1

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000377604

300_384

650.0

931.0

Domain

RRM 2

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000329236

212_242

572.0

853.0

Zinc finger

RanBP2-type

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000345781

212_242

573.0

854.0

Zinc finger

RanBP2-type

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000377604

212_242

650.0

931.0

Zinc finger

RanBP2-type

Tgene

TFE3

chrX:47041725

chrX:48895639

ENST00000315869

346_399

260.0

576.0

Domain

bHLH

Tgene

TFE3

chrX:47041725

chrX:48895639

ENST00000315869

260_271

260.0

576.0

Region

Strong transcription activation domain

Tgene

TFE3

chrX:47041725

chrX:48895639

ENST00000315869

409_430

260.0

576.0

Region

Note=Leucine-zipper

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000329236

561_607

572.0

853.0

Compositional bias

Note=Tyr-rich

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000345781

561_607

573.0

854.0

Compositional bias

Note=Tyr-rich

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000329236

858_904

572.0

853.0

Domain

G-patch

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000345781

858_904

573.0

854.0

Domain

G-patch

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000377604

858_904

650.0

931.0

Domain

G-patch

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000329236

759_784

572.0

853.0

Zinc finger

C2H2-type%3B atypical

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000345781

759_784

573.0

854.0

Zinc finger

C2H2-type%3B atypical

Hgene

RBM10

chrX:47041725

chrX:48895639

ENST00000377604

759_784

650.0

931.0

Zinc finger

C2H2-type%3B atypical

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1844_RBM10_47041725_TFE3_48895639_ranked_0.pdb	RBM10	47041725	47041725	ENST00000315869	TFE3	chrX	48895639	-	MGVGGSEFPWEGSALGASPLPPICLQSRTWLLRAPAPAELGELEEVAAGRGDVWEPFLDSPGREESLQEASPRLADHGSSSGGGWEVKRS QRLRRGPSSPRRPYQDMEYERRGGRGDRTGRYGATDRSQDDGGENRSRDHDYRDMDYRSYPREYGSQEGKHDYDDSSEEQSAEDSYEASP GSETQRRRRRRHRHSPTGPPGFPRDGDYRDQDYRTEQGEEEEEEEDEEEEEKASNIVMLRMLPQAATEDDIRGQLQSHGVQAREVRLMRN KSSGQSRGFAFVEFSHLQDATRWMEANQHSLNILGQKVSMHYSDPKPKINEDWLCNKCGVQNFKRREKCFKCGVPKSEAEQKLPLGTRLD QQTLPLGGRELSQGLLPLPQPYQAQGVLASQALSQGSEPSSENANDTIILRNLNPHSTMDSILGALAPYAVLSSSNVRVIKDKQTQLNRG FAFIQLSTIVEAAQLLQILQALHPPLTIDGKTINVEFAKGSKRDMASNEGSRISAASVASTAIAAAQWAISQASQGGEGTWATSEEPPVD YSYYQQDEGYGNSQGTESSLYAHGYLKGTKGPGITGTKGDPTGAGPEASLEPGADSVSMQAFSRAQPGAAPGIYQQSAEASSSQGTAANS QSYTIMSPAVLKSELQSPTHPSSALPPATSPTAQESYSQYPVPDVSTYQYDETSGYYYDPQTGLYYDPNSQYYYNAQSQQYLYWDGERRT YVPALEQSADGHKETGAPSKEGKEKKEKHKTKTAQQIDDVIDEIISLESSYNDEMLSYLPGGTTGLQLPSTLPVSGNLLDVYSSQGVATP AITVSNSCPAELPNIKREISETEAKALLKERQKKDNHNLIERRRRFNINDRIKELGTLIPKSSDPEMRWNKGTILKASVDYIRKLQKEQQ RSKDLESRQRSLEQANRSLQLRIQELELQAQIHGLPVPPTPGLLSLATTSASDSLKPEQLDIEEEGRPGAATFHVGGGPAQNAPHQQPPA	1071

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

TFE3_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
TFE3	AKR1B1, CLTC, PHB2, ACLY, CUL2, EPRS, PFAS, VARS, NEDD8, RPL38, TRIM28, EIF3A, RPA3, E2F3, SMARCE1, MITF, TFE3, SMAD3, SMAD4, TFEC, EWSR1, XPO1, TFEB, Arrb2, TARDBP, HIST1H4A, LAMTOR3, nsp2, nsp7, AIM2, NR3C1, DDX58, YWHAG, YWHAQ, HDAC5, BTF3, nsp16, IRF8, KLF12, KLF16, KLF3, KLF5, KLF8, SOX2, TLX3, VSX1,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
RBM10
TFE3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to RBM10-TFE3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to RBM10-TFE3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Tgene	TFE3	C4518356	MiT family translocation renal cell carcinoma	2	ORPHANET
Tgene	TFE3	C0206657	Alveolar Soft Part Sarcoma	1	ORPHANET
Tgene	TFE3	C0206732	Epithelioid hemangioendothelioma	1	ORPHANET