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level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:SLC1A3-MAPKAP1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: SLC1A3-MAPKAP1
	FusionPDB ID: 82393
	FusionGDB2.0 ID: 82393
		Hgene	Tgene
	Gene symbol	SLC1A3	MAPKAP1
	Gene ID	6507	79109
	Gene name	solute carrier family 1 member 3	MAPK associated protein 1
	Synonyms	EA6\|EAAT1\|GLAST\|GLAST1	JC310\|MIP1\|SIN1\|SIN1b\|SIN1g
	Cytomap	5p13.2	9q33.3
	Type of gene	protein-coding	protein-coding
	Description	excitatory amino acid transporter 1GLAST-1sodium-dependent glutamate/aspartate transporter 1solute carrier family 1 (glial high affinity glutamate transporter), member 3	target of rapamycin complex 2 subunit MAPKAP1MEKK2-interacting protein 1SAPK-interacting protein 1TORC2 subunit MAPKAP1mSIN1mitogen-activated protein kinase 2-associated protein 1mitogen-activated protein kinase associated protein 1ras inhibitor MG
	Modification date	20200320	20200329
	UniProtAcc	.	Q9BPZ7
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000506725, ENST00000265113, ENST00000381918,	ENST00000350766, ENST00000373498, ENST00000373511, ENST00000265960, ENST00000373503, ENST00000394063, ENST00000373497, ENST00000394060, ENST00000483937,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	12 X 10 X 6=720	12 X 10 X 10=1200
	# samples	14	13
	** MAII score	log2(14/720*10)=-2.36257007938471 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/1200*10)=-3.20645087746743 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: SLC1A3 [Title/Abstract] AND MAPKAP1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	SLC1A3(36608706)-MAPKAP1(128420078), # samples:3
Anticipated loss of major functional domain due to fusion event.	SLC1A3-MAPKAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SLC1A3-MAPKAP1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. SLC1A3-MAPKAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. SLC1A3-MAPKAP1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	SLC1A3	GO:0015813	L-glutamate transmembrane transport	26690923
Hgene	SLC1A3	GO:0051938	L-glutamate import	7521911
Hgene	SLC1A3	GO:0070779	D-aspartate import across plasma membrane	7521911
Hgene	SLC1A3	GO:0071805	potassium ion transmembrane transport	20477940
Hgene	SLC1A3	GO:0098712	L-glutamate import across plasma membrane	26690923
Hgene	SLC1A3	GO:0140009	L-aspartate import across plasma membrane	20477940
Hgene	SLC1A3	GO:1902476	chloride transmembrane transport	20477940

Fusion gene breakpoints across SLC1A3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MAPKAP1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-92-8065-01A	SLC1A3	chr5	36608706	-	MAPKAP1	chr9	128420078	-
ChimerDB4	LUSC	TCGA-92-8065-01A	SLC1A3	chr5	36608706	+	MAPKAP1	chr9	128420078	-
ChimerDB4	LUSC	TCGA-92-8065	SLC1A3	chr5	36608706	+	MAPKAP1	chr9	128420078	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000265113	SLC1A3	chr5	36608706	+	ENST00000373511	MAPKAP1	chr9	128420078	-	3230	657	476	1735	419
ENST00000265113	SLC1A3	chr5	36608706	+	ENST00000373498	MAPKAP1	chr9	128420078	-	3370	657	476	1876	466
ENST00000265113	SLC1A3	chr5	36608706	+	ENST00000350766	MAPKAP1	chr9	128420078	-	3262	657	476	1768	430
ENST00000381918	SLC1A3	chr5	36608706	+	ENST00000373511	MAPKAP1	chr9	128420078	-	2849	276	95	1354	419
ENST00000381918	SLC1A3	chr5	36608706	+	ENST00000373498	MAPKAP1	chr9	128420078	-	2989	276	95	1495	466
ENST00000381918	SLC1A3	chr5	36608706	+	ENST00000350766	MAPKAP1	chr9	128420078	-	2881	276	95	1387	430

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000265113	ENST00000373511	SLC1A3	chr5	36608706	+	MAPKAP1	chr9	128420078	-	0.002372756	0.9976273
ENST00000265113	ENST00000373498	SLC1A3	chr5	36608706	+	MAPKAP1	chr9	128420078	-	0.002148106	0.99785197
ENST00000265113	ENST00000350766	SLC1A3	chr5	36608706	+	MAPKAP1	chr9	128420078	-	0.002591601	0.99740845
ENST00000381918	ENST00000373511	SLC1A3	chr5	36608706	+	MAPKAP1	chr9	128420078	-	0.00257449	0.9974255
ENST00000381918	ENST00000373498	SLC1A3	chr5	36608706	+	MAPKAP1	chr9	128420078	-	0.002177235	0.99782276
ENST00000381918	ENST00000350766	SLC1A3	chr5	36608706	+	MAPKAP1	chr9	128420078	-	0.002469714	0.9975303

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>82393_82393_1_SLC1A3-MAPKAP1_SLC1A3_chr5_36608706_ENST00000265113_MAPKAP1_chr9_128420078_ENST00000350766_length(amino acids)=430AA_BP=58
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVAQELKSLFEKKSLKEKPPISGKQSILSVRL
EQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAE
DDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKVSGSRADGV
FEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAI

--------------------------------------------------------------

>82393_82393_2_SLC1A3-MAPKAP1_SLC1A3_chr5_36608706_ENST00000265113_MAPKAP1_chr9_128420078_ENST00000373498_length(amino acids)=466AA_BP=58
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVAQELKSLFEKKSLKEKPPISGKQSILSVRL
EQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAE
DDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKVSGPQYRLE
KQSEPNVAVDLDSTLESQSAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTN
QKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLN

--------------------------------------------------------------

>82393_82393_3_SLC1A3-MAPKAP1_SLC1A3_chr5_36608706_ENST00000265113_MAPKAP1_chr9_128420078_ENST00000373511_length(amino acids)=419AA_BP=58
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVAQELKSLFEKKSLKEKPPISGKQSILSVRL
EQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAE
DDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKVSGPQYRLE
KQSEPNVAVDLDSTLESQSAWEFCLVRENSISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDY

--------------------------------------------------------------

>82393_82393_4_SLC1A3-MAPKAP1_SLC1A3_chr5_36608706_ENST00000381918_MAPKAP1_chr9_128420078_ENST00000350766_length(amino acids)=430AA_BP=58
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVAQELKSLFEKKSLKEKPPISGKQSILSVRL
EQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAE
DDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKVSGSRADGV
FEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAI

--------------------------------------------------------------

>82393_82393_5_SLC1A3-MAPKAP1_SLC1A3_chr5_36608706_ENST00000381918_MAPKAP1_chr9_128420078_ENST00000373498_length(amino acids)=466AA_BP=58
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVAQELKSLFEKKSLKEKPPISGKQSILSVRL
EQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAE
DDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKVSGPQYRLE
KQSEPNVAVDLDSTLESQSAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTN
QKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLN

--------------------------------------------------------------

>82393_82393_6_SLC1A3-MAPKAP1_SLC1A3_chr5_36608706_ENST00000381918_MAPKAP1_chr9_128420078_ENST00000373511_length(amino acids)=419AA_BP=58
MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVAQELKSLFEKKSLKEKPPISGKQSILSVRL
EQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAE
DDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKVSGPQYRLE
KQSEPNVAVDLDSTLESQSAWEFCLVRENSISGDKVEIDPVTNQKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDY

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr5:36608706/chr9:128420078)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
.	MAPKAP1 Q9BPZ7
FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.	FUNCTION: Subunit of mTORC2, which regulates cell growth and survival in response to hormonal signals. mTORC2 is activated by growth factors, but, in contrast to mTORC1, seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 'Ser-473' phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 on 'Thr-308' by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1 at 'Ser-422'. mTORC2 also modulates the phosphorylation of PRKCA on 'Ser-657'. Within mTORC2, MAPKAP1 is required for complex formation and mTORC2 kinase activity. MAPKAP1 inhibits MAP3K2 by preventing its dimerization and autophosphorylation. Inhibits HRAS and KRAS signaling. Enhances osmotic stress-induced phosphorylation of ATF2 and ATF2-mediated transcription. Involved in ciliogenesis, regulates cilia length through its interaction with CCDC28B independently of mTORC2 complex. {ECO:0000269\|PubMed:15988011, ECO:0000269\|PubMed:16962653, ECO:0000269\|PubMed:17043309, ECO:0000269\|PubMed:17054722, ECO:0000269\|PubMed:17303383, ECO:0000269\|PubMed:23727834}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

1_47

60.333333333333336

543.0

Topological domain

Cytoplasmic

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

1_47

60.333333333333336

498.0

Topological domain

Cytoplasmic

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

346_376

60.333333333333336

543.0

Intramembrane

Discontinuously helical

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

426_459

60.333333333333336

543.0

Intramembrane

Discontinuously helical

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

346_376

60.333333333333336

498.0

Intramembrane

Discontinuously helical

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

426_459

60.333333333333336

498.0

Intramembrane

Discontinuously helical

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

363_365

60.333333333333336

543.0

Region

Aspartate binding

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

443_447

60.333333333333336

543.0

Region

Aspartate binding

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

363_365

60.333333333333336

498.0

Region

Aspartate binding

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

443_447

60.333333333333336

498.0

Region

Aspartate binding

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

109_122

60.333333333333336

543.0

Topological domain

Cytoplasmic

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

146_236

60.333333333333336

543.0

Topological domain

Extracellular

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

261_269

60.333333333333336

543.0

Topological domain

Cytoplasmic

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

298_318

60.333333333333336

543.0

Topological domain

Extracellular

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

341_345

60.333333333333336

543.0

Topological domain

Cytoplasmic

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

377_385

60.333333333333336

543.0

Topological domain

Cytoplasmic

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

413_425

60.333333333333336

543.0

Topological domain

Extracellular

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

460_472

60.333333333333336

543.0

Topological domain

Extracellular

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

495_542

60.333333333333336

543.0

Topological domain

Cytoplasmic

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

69_86

60.333333333333336

543.0

Topological domain

Extracellular

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

109_122

60.333333333333336

498.0

Topological domain

Cytoplasmic

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

146_236

60.333333333333336

498.0

Topological domain

Extracellular

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

261_269

60.333333333333336

498.0

Topological domain

Cytoplasmic

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

298_318

60.333333333333336

498.0

Topological domain

Extracellular

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

341_345

60.333333333333336

498.0

Topological domain

Cytoplasmic

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

377_385

60.333333333333336

498.0

Topological domain

Cytoplasmic

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

413_425

60.333333333333336

498.0

Topological domain

Extracellular

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

460_472

60.333333333333336

498.0

Topological domain

Extracellular

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

495_542

60.333333333333336

498.0

Topological domain

Cytoplasmic

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

69_86

60.333333333333336

498.0

Topological domain

Extracellular

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

123_145

60.333333333333336

543.0

Transmembrane

Helical%3B Name%3D3

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

237_260

60.333333333333336

543.0

Transmembrane

Helical%3B Name%3D4

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

270_297

60.333333333333336

543.0

Transmembrane

Helical%3B Name%3D5

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

319_340

60.333333333333336

543.0

Transmembrane

Helical%3B Name%3D6

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

386_412

60.333333333333336

543.0

Transmembrane

Helical%3B Name%3D7

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

473_494

60.333333333333336

543.0

Transmembrane

Helical%3B Name%3D8

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

48_68

60.333333333333336

543.0

Transmembrane

Helical%3B Name%3D1

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000265113

87_108

60.333333333333336

543.0

Transmembrane

Helical%3B Name%3D2

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

123_145

60.333333333333336

498.0

Transmembrane

Helical%3B Name%3D3

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

237_260

60.333333333333336

498.0

Transmembrane

Helical%3B Name%3D4

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

270_297

60.333333333333336

498.0

Transmembrane

Helical%3B Name%3D5

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

319_340

60.333333333333336

498.0

Transmembrane

Helical%3B Name%3D6

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

386_412

60.333333333333336

498.0

Transmembrane

Helical%3B Name%3D7

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

473_494

60.333333333333336

498.0

Transmembrane

Helical%3B Name%3D8

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

48_68

60.333333333333336

498.0

Transmembrane

Helical%3B Name%3D1

Hgene

SLC1A3

chr5:36608706

chr9:128420078

ENST00000381918

87_108

60.333333333333336

498.0

Transmembrane

Helical%3B Name%3D2

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>980_SLC1A3_36608706_MAPKAP1_128420078_980_SLC1A3_36608706_MAPKAP1_128420078_ranked_0.pdb	SLC1A3	36608706	36608706	ENST00000350766	MAPKAP1	chr9	128420078	-	MTKSNGEEPKMGGRMERFQQGVRKRTLLAKKKVQNITKEDVKSYLFRNAFVLLTVTAVIVAQELKSLFEKKSLKEKPPISGKQSILSVRL EQCPLQLNNPFNEYSKFDGKGHVGTTATKKIDVYLPLHSSQDRLLPMTVVTMASARVQDLIGLICWQYTSEGREPKLNDNVSAYCLHIAE DDGEVDTDFPPLDSNEPIHKFGFSTLALVEKYSSPGLTSKESLFVRINAAHGFSLIQVDNTKVTMKEILLKAVKRRKGSQKVSGPQYRLE KQSEPNVAVDLDSTLESQSAWEFCLVRENSSRADGVFEEDSQIDIATVQDMLSSHHYKSFKVSMIHRLRFTTDVQLGISGDKVEIDPVTN QKASTKFWIKQKPISIDSDLLCACDLAEEKSPSHAIFKLTYLSNHDYKHLYFESDAATVNEIVLKVNYILESRASTARADYFAQKQRKLN	466

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

SLC1A3_pLDDT.png

MAPKAP1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
SLC1A3
MAPKAP1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	MAPKAP1	chr5:36608706	chr9:128420078	ENST00000265960		2	12	2_184	116.33333333333333	523.0	MAP3K2
Tgene	MAPKAP1	chr5:36608706	chr9:128420078	ENST00000350766		2	11	2_184	116.33333333333333	487.0	MAP3K2
Tgene	MAPKAP1	chr5:36608706	chr9:128420078	ENST00000373498		1	11	2_184	116.33333333333333	523.0	MAP3K2
Tgene	MAPKAP1	chr5:36608706	chr9:128420078	ENST00000373511		2	11	2_184	116.33333333333333	476.0	MAP3K2
Tgene	MAPKAP1	chr5:36608706	chr9:128420078	ENST00000394060		2	8	2_184	116.33333333333333	324.0	MAP3K2
Tgene	MAPKAP1	chr5:36608706	chr9:128420078	ENST00000265960		2	12	2_267	116.33333333333333	523.0	NBN
Tgene	MAPKAP1	chr5:36608706	chr9:128420078	ENST00000350766		2	11	2_267	116.33333333333333	487.0	NBN
Tgene	MAPKAP1	chr5:36608706	chr9:128420078	ENST00000373498		1	11	2_267	116.33333333333333	523.0	NBN
Tgene	MAPKAP1	chr5:36608706	chr9:128420078	ENST00000373511		2	11	2_267	116.33333333333333	476.0	NBN
Tgene	MAPKAP1	chr5:36608706	chr9:128420078	ENST00000394060		2	8	2_267	116.33333333333333	324.0	NBN

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Related Drugs to SLC1A3-MAPKAP1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to SLC1A3-MAPKAP1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source